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168 results on '"Moustafa, Ahmed M."'

5. Transcription Factor 23 is an Essential Determinant of Murine Term Parturition.

Author

Minisy, Fatma M., Shawki, Hossam H., Fujita, Tsubasa, Moustafa, Ahmed M., Sener, Rumeysa, Nishio, Youske, Shimada, Issei S., Saitoh, Shinji, Sugiura-Ogasawara, Mayumi, and Oishi, Hisashi

Abstract

Pregnancy involving intricate tissue transformations governed by the progesterone hormone (P4). P4 signaling via P4 receptors (PRs) is vital for endometrial receptivity, decidualization, myometrial quiescence, and labor initiation. This study explored the role of TCF23 as a downstream target of PR during pregnancy. TCF23 was found to be expressed in female reproductive organs, predominantly in uterine stromal and smooth muscle cells. Tcf23 expression was high during midgestation and was specifically regulated by P4, but not estrogen. The Tcf23 knockout (KO) mouse was generated and analyzed. Female KO mice aged 4-6 months exhibited subfertility, reduced litter size, and defective parturition. Uterine histology revealed disrupted myometrial structure, altered collagen organization, and disarrayed smooth muscle sheets at the conceptus sites of KO mice. RNA-Seq analysis of KO myometrium revealed dysregulation of genes associated with cell adhesion and extracellular matrix organization. TCF23 potentially modulates TCF12 activity to mediate cell-cell adhesion and matrix modulation in smooth muscle cells. Overall, TCF23 deficiency leads to impaired myometrial remodeling, causing parturition delay and fetal demise. This study sheds light on the critical role of TCF23 as a dowstream mediator of PR in uterine remodeling, reflecting the importance of cell-cell communication and matrix dynamics in myometrial activation and parturition. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Bacteremia and Monocyte Evasion, Rio de Janeiro, Brazil

Author

Viana, Alice Slotfeldt, Botelho, Ana Maria Nunes, Moustafa, Ahmed M., Boge, Craig L.K., Ferreira, Adriana Lucia Pires, Carvalho, Maria Cicera da Silva, Guimaraes, Marcia Aparecida, de Souza Scramignon Costa, Bruno, de Mattos, Marcos Correa, Maciel, Sabrina Pires, Echevarria-Lima, Juliana, Narechania, Apurva, OBrien, Kelsey, Ryan, Chanelle, Gerber, Jeffrey S., Carvalho, Bernadete Teixeira Ferreira, Figueiredo, Agnes Marie Sa, and Planet, Paul J.

Subjects
Rio de Janeiro, Brazil (City) -- Health aspects, Staphylococcus aureus -- Identification and classification -- Genetic aspects, Staphylococcus aureus infections -- Statistics -- Causes of, Bacteremia -- Statistics -- Causes of, Health
Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is characterized by the mainly clonal structure of bacterial populations and the worldwide spread of a few highly successful lineages, sequence types (STs), and clonal complexes [...]

Published
2021
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9. Genetic variation of staphylococcal LukAB toxin determines receptor tropism

Author

Perelman, Sofya S., James, David B. A., Boguslawski, Kristina M., Nelson, Chase W., Ilmain, Juliana K., Zwack, Erin E., Prescott, Rachel A., Mohamed, Adil, Tam, Kayan, Chan, Rita, Narechania, Apurva, Pawline, Miranda B., Vozhilla, Nikollaq, Moustafa, Ahmed M., Kim, Sang Y., Dittmann, Meike, Ekiert, Damian C., Bhabha, Gira, Shopsin, Bo, Planet, Paul J., Koralov, Sergei B., and Torres, Victor J.

Published
2021
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10. Networked explicit hybrid predictive control of an industrial benchmark process.

Author

Younis, Al-Shaimaa A., Moness, Mohammed, and Moustafa, Ahmed M.

Abstract

Hybrid systems have acquired deep attention in research as many systems in industries and laboratories manifest hybrid dynamic behaviors. Optimal control design for hybrid systems exhibits challenges for controlling the interacting continuous and discrete dynamics. A double-tank hybrid system (DTHS) is proposed in this paper with a mixed-integer actuation mechanism. The proposed DTHS aims to control the liquid level of the two tanks simultaneously by a networked hybrid predictive controller. Hybrid frameworks are provided to investigate the system through reachability analysis. An explicit hybrid model predictive control (EHMPC) has been developed to control the levels of the DTHS. Hardware-In-the-Loop (HIL) simulation is performed for assessing the performance of the EHMPC with a hardware real-time networked controller. The networked real-time controller is constructed and implemented using the Node.js frameworks. The simulation and realtime results are presented and discussed to evaluate the hybrid controller performance. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection

Author

Smith, Alexander B., primary, Specker, Jonathan T., additional, Hewlett, Katharine K., additional, Scoggins, Troy R., additional, Knight, Montana, additional, Lustig, Abigail M., additional, Li, Yanhong, additional, Evans, Kirsten M., additional, Guo, Yingchan, additional, She, Qianxuan, additional, Christopher, Michael W., additional, Garrett, Timothy J., additional, Moustafa, Ahmed M., additional, Van Tyne, Daria, additional, Prentice, Boone M., additional, and Zackular, Joseph P., additional

Published
2024
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13. RdJ detection tests to identify a unique MRSA clone of ST105-SCCmecII lineage and its variants disseminated in the metropolitan region of Rio de Janeiro

Author

Esteves, Matheus Assis Côrtes, primary, Viana, Alice Slotfeldt, additional, Viçosa, Gabriela Nogueira, additional, Botelho, Ana Maria Nunes, additional, Moustafa, Ahmed M., additional, Mansoldo, Felipe Raposo Passos, additional, Ferreira, Adriana Lucia Pires, additional, Vermelho, Alane Beatriz, additional, Ferreira-Carvalho, Bernadete Teixeira, additional, Planet, Paul Joseph, additional, and Figueiredo, Agnes Marie Sá, additional

Published
2023
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14. Impact of Ivermectin on the Gut Microbial Ecosystem

Author

Liu, LinShu, primary, Mahalak, Karley K., additional, Bobokalonov, Jamshed T., additional, Narrowe, Adrienne B., additional, Firrman, Jenni, additional, Lemons, Johanna M. S., additional, Bittinger, Kyle, additional, Hu, Weiming, additional, Jones, Steven M., additional, and Moustafa, Ahmed M., additional

Published
2023
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16. Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis

Author

Pitcher, Nicholas J., primary, Feder, Andries, additional, Bolden, Nicholas, additional, Zirbes, Christian F., additional, Pamatmat, Anthony J., additional, Boyken, Linda, additional, Hill, Jared J., additional, Bartels, Alyssa R., additional, Thurman, Andrew L., additional, Reeb, Valerie C., additional, Porterfield, Harry S., additional, Moustafa, Ahmed M., additional, Planet, Paul J., additional, and Fischer, Anthony J., additional

Published
2023
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18. Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000–2016)

Author

Martínez, José R. W., primary, Planet, Paul J., additional, Spencer-Sandino, Maria, additional, Rivas, Lina, additional, Díaz, Lorena, additional, Moustafa, Ahmed M., additional, Quesille-Villalobos, Ana, additional, Riquelme-Neira, Roberto, additional, Alcalde-Rico, Manuel, additional, Hanson, Blake, additional, Carvajal, Lina P., additional, Rincón, Sandra, additional, Reyes, Jinnethe, additional, Lam, Marusella, additional, Calderon, Juan F., additional, Araos, Rafael, additional, García, Patricia, additional, Arias, César A., additional, and Munita, José M., additional

Published
2023
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19. Carbapenem-resistantAcinetobacter baumanniiat a hospital in Botswana: Detecting a protracted outbreak using whole genome sequencing

Author

Strysko, Jonathan, primary, Thela, Tefelo, additional, Feder, Andries, additional, Thubuka, Janet, additional, Machiya, Tichaona, additional, Mkubwa, Jack, additional, Mochankana, Kagiso, additional, Tiroyakgosi, Celda, additional, Kgomanyane, Kgomotso, additional, Ntereke, Tlhalefo Dudu, additional, Zankere, Tshiamo, additional, Lechiile, Kwana, additional, Gatonye, Teresia, additional, Tembo, Chimwemwe Viola, additional, Vurayai, Moses, additional, Mannathoko, Naledi, additional, Mokomane, Margaret, additional, Moustafa, Ahmed M, additional, Goldfarb, David M, additional, Richard-Greenblatt, Melissa, additional, McGann, Carolyn, additional, Coffin, Susan E, additional, Cancedda, Corrado, additional, Lautenbach, Ebbing, additional, Bogoshi, Dineo, additional, Smith, Anthony M, additional, and Planet, Paul J, additional

Published
2023
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20. Heavy Metal Pollution From a Major Earthquake and Tsunami in Chile Is Associated With Geographic Divergence of Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Latin America

Author

Martinez, Jose RW, primary, Alcalde-Rico, Manuel, additional, Jara-Videla, Estefania, additional, Rios, Rafael, additional, Moustafa, Ahmed M, additional, Hanson, Blake, additional, Rivas, Lina, additional, Carvajal, Lina P, additional, Rincon, Sandra, additional, Diaz, Lorena, additional, Reyes, Jinnethe, additional, Quesille-Villalobos, Ana, additional, Riquelme-Neira, Roberto, additional, Undurraga, Eduardo A, additional, Olivares-Pacheco, Jorge, additional, Garcia, Patricia, additional, Araos, Rafael, additional, Planet, Paul J, additional, Arias, Cesar A, additional, and Munita, Jose M, additional

Published
2023
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21. Parallel Evolution of Linezolid ResistantStaphylococcus aureusin Patients with Cystic Fibrosis

Author

Pitcher, Nicholas J., primary, Feder, Andries, additional, Bolden, Nicholas, additional, Zirbes, Christian F., additional, Pamatmat, Anthony J, additional, Boyken, Linda D, additional, Hill, Jared J., additional, Thurman, Andrew, additional, Reeb, Valerie, additional, Porterfield, Harry S., additional, Moustafa, Ahmed M, additional, Planet, Paul J, additional, and Fischer, Anthony John, additional

Published
2023
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23. RdJ detection tests to identify a unique MRSA clone of ST105-SCCmecII lineage and its variants disseminated in the metropolitan region of Rio de Janeiro.

Author

Côrtes Esteves, Matheus Assis, Slotfeldt Viana, Alice, Nogueira Viçosa, Gabriela, Nunes Botelho, Ana Maria, Moustafa, Ahmed M., Passos Mansoldo, Felipe Raposo, Pires Ferreira, Adriana Lucia, Beatriz Vermelho, Alane, Ferreira-Carvalho, Bernadete Teixeira, Planet, Paul Joseph, and Sá Figueiredo, Agnes Marie

Subjects
MOLECULAR cloning, METHICILLIN-resistant staphylococcus aureus, ANIMAL cloning, METROPOLITAN areas, PAN-genome
Abstract

Hospital bloodstream infection (BSI) caused by methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality and is frequently related to invasive procedures and medically complex patients. An important feature of MRSA is the clonal structure of its population. Specific MRSA clones may differ in their pathogenic, epidemiological, and antimicrobial resistance profiles. Whole-genome sequencing is currently the most robust and discriminatory technique for tracking hypervirulent/well-adapted MRSA clones. However, it remains an expensive and time-consuming technique that requires specialized personnel. In this work, we describe a pangenome protocol, based on binary matrix (1,0) of open reading frames (ORFs), that can be used to quickly find diagnostic, apomorphic sequence mutations that can serve as biomarkers. We use this technique to create a diagnostic screen for MRSA isolates circulating in the Rio de Janeiro metropolitan area, the RdJ clone, which is prevalent in BSI. The method described here has 100% specificity and sensitivity, eliminating the need to use genomic sequencing for clonal identification. The protocol used is relatively simple and all the steps, formulas and commands used are described in this work, such that this strategy can also be used to identify other MRSA clones and even clones from other bacterial species. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Heavy Metal Pollution From a Major Earthquake and Tsunami in Chile Is Associated With Geographic Divergence of Clinical Isolates of Methicillin-ResistantStaphylococcus aureusin Latin America

Author

Martínez, Jose RW, Alcalde-Rico, Manuel, Jara-Videla, Estefanía, Rios, Rafael, Moustafa, Ahmed M., Hanson, Blake, Rivas, Lina, Carvajal, Lina P., Rincon, Sandra, Diaz, Lorena, Reyes, Jinnethe, Quesille-Villalobos, Ana, Riquelme-Neira, Roberto, Undurraga, Eduardo A., Olivares-Pacheco, Jorge, García, Patricia, Araos, Rafael, Planet, Paul J., Arias, César A., and Munita, Jose M.

Subjects
Article
Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a priority pathogen listed by the World Health Organization. The global spread of MRSA is characterized by successive waves of epidemic clones that predominate in specific geographical regions. The acquisition of genes encoding resistance to heavy-metals is thought to be a key feature in the divergence and geographical spread of MRSA. Increasing evidence suggests that extreme natural events, such as earthquakes and tsunamis, could release heavy-metals into the environment. However, the impact of environmental exposition to heavy-metals on the divergence and spread of MRSA clones has been insufficiently explored. We assess the association between a major earthquake and tsunami in an industrialized port in southern Chile and MRSA clone divergence in Latin America. We performed a phylogenomic reconstruction of 113 MRSA clinical isolates from seven Latin American healthcare centers, including 25 isolates collected in a geographic area affected by an earthquake and tsunami that led to high levels of heavy-metal environmental contamination. We found a divergence event strongly associated with the presence of a plasmid harboring heavy-metal resistance genes in the isolates obtained in the area where the earthquake and tsunami occurred. Moreover, clinical isolates carrying this plasmid showed increased tolerance to mercury, arsenic, and cadmium. We also observed a physiological burden in the plasmid-carrying isolates in absence of heavy-metals. Our results are the first evidence that suggests that heavy-metal contamination, in the aftermath of an environmental disaster, appears to be a key evolutionary event for the spread and dissemination of MRSA in Latin America.

Published
2023

25. Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis

Author

Darwish, Mahmoud I. M., primary, Moustafa, Ahmed M., additional, Youssef, Asmaa M., additional, Mansour, Mohamed, additional, Yousef, Ahmed I., additional, El Omri, Abdelfatteh, additional, Shawki, Hossam H., additional, Mohamed, Magda F., additional, Hassaneen, Hamdi M., additional, Abdelhamid, Ismail A., additional, and Oishi, Hisashi, additional

Published
2023
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32. Novel Tetrahydro-[1,2,4]triazolo[3,4- a ]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis.

Author

Darwish, Mahmoud I. M., Moustafa, Ahmed M., Youssef, Asmaa M., Mansour, Mohamed, Yousef, Ahmed I., El Omri, Abdelfatteh, Shawki, Hossam H., Mohamed, Magda F., Hassaneen, Hamdi M., Abdelhamid, Ismail A., and Oishi, Hisashi

Subjects
*CHALCONE, *ISOQUINOLINE, *BREAST, *CHALCONES, *CELL cycle, *CANCER cell proliferation, *METHOXY group, *MORPHOLOGY
Abstract

Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity. Various functional modifications in chalcones have been reported, along with their pharmacological properties. In the current study, novel chalcone derivatives with the chemical base of tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-3-arylprop-2-en-1-one were synthesized, and the structure of their molecules was confirmed through NMR spectroscopy. The antitumor activity of these newly synthesized chalcone derivatives was tested on mouse (Luc-4T1) and human (MDA-MB-231) breast cancer cell lines. The antiproliferative effect was evaluated through SRB screening and the MTT assay after 48 h of treatment at different concentrations. Interestingly, among the tested chalcone derivatives, chalcone analogues with a methoxy group were found to have significant anticancer activity and displayed gradient-dependent inhibition against breast cancer cell proliferation. The anticancer properties of these unique analogues were examined further by cytometric analysis of the cell cycle, quantitative PCR, and the caspases-Glo 3/7 assay. Chalcone methoxy derivatives showed the capability of cell cycle arrest and increased Bax/Bcl2 mRNA ratios as well as caspases 3/7 activity. The molecular docking analysis suggests that these chalcone methoxy derivatives may inhibit anti-apoptotic proteins, particularly cIAP1, BCL2, and EGFRK proteins. In conclusion, our findings confirm that chalcone methoxy derivatives could be considered to be potent drug candidates against breast cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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33. SARS-CoV-2 Variants Associated with Vaccine Breakthrough in the Delaware Valley through Summer 2021

Author

Marques, Andrew D., primary, Sherrill-Mix, Scott, additional, Everett, John K., additional, Reddy, Shantan, additional, Hokama, Pascha, additional, Roche, Aoife M., additional, Hwang, Young, additional, Glascock, Abigail, additional, Whiteside, Samantha A., additional, Graham-Wooten, Jevon, additional, Khatib, Layla A., additional, Fitzgerald, Ayannah S., additional, Moustafa, Ahmed M., additional, Bianco, Colleen, additional, Rajagopal, Swetha, additional, Helton, Jenna, additional, Deming, Regan, additional, Denu, Lidiya, additional, Ahmed, Azad, additional, Kitt, Eimear, additional, Coffin, Susan E., additional, Newbern, Claire, additional, Mell, Josh Chang, additional, Planet, Paul J., additional, Badjatia, Nitika, additional, Richards, Bonnie, additional, Wang, Zi-Xuan, additional, Cannuscio, Carolyn C., additional, Strelau, Katherine M., additional, Jaskowiak-Barr, Anne, additional, Cressman, Leigh, additional, Loughrey, Sean, additional, Ganguly, Arupa, additional, Feldman, Michael D., additional, Collman, Ronald G., additional, Rodino, Kyle G., additional, Kelly, Brendan J., additional, and Bushman, Frederic D., additional

Published
2022
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35. Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs

Author

Miller, Justin J, primary, Shah, Ishaan T, additional, Hatten, Jayda, additional, Barekatain, Yasaman, additional, Mueller, Elizabeth A, additional, Moustafa, Ahmed M, additional, Edwards, Rachel L, additional, Dowd, Cynthia S, additional, Hoops, Geoffrey C, additional, Johnson, R Jeremy, additional, Planet, Paul, additional, Muller, Florian L, additional, Jez, Joseph, additional, and Odom John, Audrey R, additional

Published
2021
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38. Structure-guided microbial targeting of antistaphylococcal prodrugs

Author

Miller, Justin J, primary, Shah, Ishaan T, additional, Hatten, Jayda, additional, Barekatain, Yasaman, additional, Mueller, Elizabeth A, additional, Moustafa, Ahmed M, additional, Edwards, Rachel L, additional, Dowd, Cynthia S, additional, Hoops, Geoffrey C, additional, Johnson, R Jeremy, additional, Planet, Paul J, additional, Muller, Florian L, additional, Jez, Joseph M, additional, and Odom John, Audrey R, additional

Published
2021
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39. Author response: Structure-guided microbial targeting of antistaphylococcal prodrugs

Author

Miller, Justin J, primary, Shah, Ishaan T, additional, Hatten, Jayda, additional, Barekatain, Yasaman, additional, Mueller, Elizabeth A, additional, Moustafa, Ahmed M, additional, Edwards, Rachel L, additional, Dowd, Cynthia S, additional, Planet, Paul J, additional, Muller, Florian L, additional, Jez, Joseph M, additional, and Odom John, Audrey R, additional

Published
2021
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40. Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates

Author

Moustafa, Ahmed M, primary, Bianco, Colleen, additional, Denu, Lidiya, additional, Ahmed, Azad, additional, Coffin, Susan E, additional, Neide, Brandy, additional, Everett, John, additional, Reddy, Shantan, additional, Rabut, Emilie, additional, Deseignora, Jasmine, additional, Feldman, Michael D, additional, Rodino, Kyle G, additional, Bushman, Frederic, additional, Harris, Rebecca M, additional, Chang Mell, Josh, additional, and Planet, Paul J, additional

Published
2021
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41. Emergence of SARS-CoV-2 variants of concern in the pediatric population of the United States

Author

Bard, Jennifer Dien, primary, Bootwalla, Moiz, additional, Leber, Amy, additional, Planet, Paul, additional, Moustafa, Ahmed M., additional, Harris, Rebecca, additional, Chen, Pei Ying, additional, Shen, Lishuang, additional, Ostrow, Dejerianne, additional, Maglinte, Dennis, additional, Flores, Jessica, additional, Somak, Roy, additional, Ranganathan, Sarangarajan, additional, Perlman, Elizabeth, additional, Zheng, Xiaotian, additional, Selvarangan, Rangaraj, additional, Banerjee, Dithi, additional, Delaney, Meghan, additional, Campos, Joseph, additional, Michael, Drew G., additional, Vilain, Eric, additional, LoTempio, Jonathan, additional, Dunn, James, additional, Jung, Sarah, additional, Dominguez, Samuel R., additional, Judkins, Alexander R., additional, and Gai, Xiaowu, additional

Published
2021
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43. Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania

Author

Moustafa, Ahmed M., primary, Bianco, Colleen, additional, Denu, Lidiya, additional, Ahmed, Azad, additional, Neide, Brandy, additional, Everett, John, additional, Reddy, Shantan, additional, Rabut, Emilie, additional, Deseignora, Jasmine, additional, Feldman, Michael D., additional, Rodino, Kyle G., additional, Bushman, Frederic, additional, Harris, Rebecca M., additional, Mell, Josh Chang, additional, and Planet, Paul J., additional

Published
2021
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44. Early pandemic molecular diversity of SARS-CoV-2 in children

Author

Moustafa, Ahmed M., primary, Otto, William, additional, Gai, Xiaowu, additional, Pandey, Utsav, additional, Ryutov, Alex, additional, Bootwalla, Moiz, additional, Maglinte, Dennis T, additional, Shen, Lishuang, additional, Ruble, David, additional, Ostrow, Dejerianne, additional, Gerber, Jeffrey S., additional, Bard, Jennifer Dien, additional, Harris, Rebecca M., additional, and Planet, Paul J., additional

Published
2021
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46. Structure-guided microbial targeting of antistaphylococcal prodrugs

Author

Miller, Justin J., primary, Shah, Ishaan T., additional, Hatten, Jayda, additional, Barekatain, Yasaman, additional, Mueller, Elizabeth A., additional, Moustafa, Ahmed M., additional, Edwards, Rachel L., additional, Dowd, Cynthia S., additional, Planet, Paul J., additional, Muller, Florian L., additional, Jez, Joseph M., additional, and Odom John, Audrey R., additional

Published
2020
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