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18 results on '"Mozzetta, Stefano"'

8. QEEG abnormalities in cognitively unimpaired patients with delirium

Author

Carrarini, Claudia, primary, Calisi, Dario, additional, De Rosa, Matteo Alessandro, additional, Di Iorio, Angelo, additional, D’Ardes, Damiano, additional, Pellegrino, Raffaello, additional, Gazzina, Stefano, additional, Pilotto, Andrea, additional, Arighi, Andrea, additional, Carandini, Tiziana, additional, Cagnin, Annachiara, additional, Mozzetta, Stefano, additional, Gallucci, Maurizio, additional, Bonifati, Domenico Marco, additional, Costa, Cinzia, additional, D'Antonio, Fabrizia, additional, Bruno, Giuseppe, additional, Cipollone, Francesco, additional, Babiloni, Claudio, additional, Padovani, Alessandro, additional, Onofrj, Marco, additional, and Bonanni, Laura, additional

Published
2022
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9. QEEG abnormalities in cognitively unimpaired patients with delirium.

Author

Carrarini, Claudia, Calisi, Dario, De Rosa, Matteo Alessandro, Di Iorio, Angelo, D’Ardes, Damiano, Pellegrino, Raffaello, Gazzina, Stefano, Pilotto, Andrea, Arighi, Andrea, Carandini, Tiziana, Cagnin, Annachiara, Mozzetta, Stefano, Gallucci, Maurizio, Bonifati, Domenico Marco, Costa, Cinzia, D'Antonio, Fabrizia, Bruno, Giuseppe, Cipollone, Francesco, Babiloni, Claudio, and Padovani, Alessandro

Subjects
DELIRIUM
Published
2023
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18. Brain Stem Glucose Hypermetabolism in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia and Shortened Survival: An 18 F-FDG PET/MRI Study.

Author

Zanovello M, Sorarù G, Campi C, Anglani M, Spimpolo A, Berti S, Bussè C, Mozzetta S, Cagnin A, and Cecchin D

Subjects
Brain Stem, Fluorodeoxyglucose F18, Glucose, Humans, Magnetic Resonance Imaging, Positron Emission Tomography Computed Tomography, Prospective Studies, Tomography, X-Ray Computed, Amyotrophic Lateral Sclerosis diagnostic imaging, Frontotemporal Dementia diagnostic imaging
Abstract

A few 18 F-FDG PET/CT studies have revealed the presence of brain hypermetabolism in the brain stem and cervical spinal cord of patients within the amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) continuum. We aimed to investigate this finding through a hybrid PET/MRI system, allowing a more precise depiction of the spatial pattern of metabolic changes in the brain stem and cervical spinal cord. Methods: Twenty-eight patients with a diagnosis of ALS or a diagnosis of the behavioral variant of FTD plus motoneuron disease, as well as 13 control subjects, underwent 18 F-FDG PET/MRI. Mean normalized 18 F-FDG uptake in the midbrain/pons, medulla oblongata, and cervical spinal cord as defined on the individual's MRI scans were compared between groups. Furthermore, the associations between regional 18 F-FDG uptake and clinical and demographic characteristics-including gene mutation, type of onset (bulbar, spinal, dementia), and clinical characteristics-were investigated. Results: A significant ( P < 0.005) increment in glucose metabolism in the midbrain/pons and medulla oblongata was found in ALS/FTD patients (spinal-ALS and FTD-motor neuron disease subgroups) in comparison to controls. No relevant associations between clinical and metabolic features were reported, although medulla oblongata hypermetabolism was associated with shortened survival ( P < 0.001). Conclusion: Increased glucose metabolism in the brain stem might be due to neuroinflammation, one of the key steps in the pathogenic cascade that leads to neurodegeneration in ALS/FTD. 18 F-FDG PET/MRI could be a valuable tool to assess glial changes in the ALS/FTD spectrum and could serve as a prognostic biomarker. Large prospective initiatives would likely shed more light on the promising application of PET/MRI in this setting., (© 2022 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2022
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