Search

Your search keyword '"Mraz, Wilfried"' showing total 14 results
Start Over Author "Mraz, Wilfried"
14 results on '"Mraz, Wilfried"'

3. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality

Author

Tipping, Robert W., Ford, Charles E., Simpson, Lara M., Walldius, Göran, Jungner, Ingmar, Folsom, Aaron R., Chambless, Lloyd, Panagiotakos, Demosthenes, Pitsavos, Christos, Chrysohoou, Christina, Stefanadis, Christodoulos, Goldbourt, Uri, Benderly, Michal, Tanne, David, Whincup, Peter, Wannamethee, S. Goya, Morris, Richard W., Kiechl, Stefan, Willeit, Johann, Santer, Peter, Mayr, Agnes, Wald, Nicholas, Ebrahim, Shah, Lawlor, Debbie, Yarnell, John, Gallacher, John, Casiglia, Edoardo, Tikhonoff, Valérie, Nietert, Paul J., Sutherland, Susan E., Bachman, David L., Cushman, Mary, Psaty, Bruce M., Tracy, Russ, Tybjærg-Hansen, Anne, Nordestgaard, Børge G., Frikke-Schmidt, Ruth, Kamstrup, Pia R., Giampaoli, Simona, Palmieri, Luigi, Panico, Salvatore, Vanuzzo, Diego, Pilotto, Lorenza, De La Cámara, Agustín Gómez, Gómez Gerique, Juan A., Simons, Leon, McCallum, John, Friedlander, Yechiel, Fowkes, F. Gerry R., Lee, Amanda, Smith, Felicity B., Taylor, James, Guralnik, Jack M., Phillips, Caroline L., Wallace, Robert B., Blazer, Dan G., Brenner, Hermann, Raum, Elke, Müller, Heiko, Rothenbacher, Dietrich, Jansson, Jan Håkan, Wennberg, Patrik, Nissinen, Aulikki, Donfrancesco, Chiara, Salomaa, Veikko, Harald, Kennet, Jousilahti, Pekka, Vartiainen, Erkki, Woodward, Mark, D’Agostino, Ralph B., Wolf, Philip A., Vasan, Ramachandran S., Pencina, Michael J., Bladbjerg, Else Marie, Jørgensen, Torben, Møller, Lars, Jespersen, Jørgen, Dankner, Rachel, Chetrit, Angela, Lubin, Flora, Rosengren, Annika, Wilhelmsen, Lars, Lappas, Georgios, Eriksson, Henry, Björkelund, Cecilia, Lissner, Lauren, Bengtsson, Calle, Cremer, Peter, Nagel, Dorothea, Tilvis, Reijo S., Strandberg, Timo E., Rodriguez, Beatriz, Dekker, Jacqueline, Nijpels, G., Stehouwer, Coen D.A., Rimm, Eric, Pai, Jennifer K., Sato, Shinichi, Iso, Hiroyasu, Kitamura, Akihiko, Noda, Hiroyuki, Salonen, Jukka T., Nyyssönen, Kristiina, Tuomainen, Tomi Pekka, Deeg, Dorly J.H., Poppelaars, Jan L., Hedblad, Bo, Berglund, Göran, Engström, Gunnar, Verschuren, W. M.M., Blokstra, Anneke, Döring, Angela, Koenig, Wolfgang, Meisinger, Christa, Mraz, Wilfried, Bueno-De-Mesquita, H. Bas, Kuller, Lewis H., Grandits, Greg, Selmer, Randi, Tverdal, Aage, Nystad, Wenche, Gillum, R. F., Mussolino, Michael, Hankinson, Sue, Manson, Jo Ann E., Cooper, Jackie A., Bauer, Kenneth A., Naito, Yoshihiko, Holme, Ingar, Nakagawa, Hideaki, Miura, Katsuyuki, Ducimetiere, Pierre, Jouven, Xavier, Luc, Gérald, Crespo, Carlos J., Garcia Palmieri, Mario R., Amouyel, Philippe, Arveiler, Dominique, Evans, Alun, Ferrieres, Jean, Schulte, Helmut, Assmann, Gerd, Shepherd, James, Packard, Chris J., Sattar, Naveed, Ford, Ian, Cantin, Bernard, Lamarche, Benoît, Després, Jean Pierre, Dagenais, Gilles R., Barrett-Connor, Elizabeth, Daniels, Lori B., Laughlin, Gail A., Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Trevisan, Maurizio, Witteman, Jacqueline, Kardys, Isabella, Breteler, Monique M.B., Hofman, Albert, Tunstall-Pedoe, Hugh, Tavendale, Roger, Lowe, Gordon, Ben-Shlomo, Yoav, Davey-Smith, George, Howard, Barbara V., Zhang, Ying, Best, Lyle, Umans, Jason, Onat, Altan, Njølstad, Inger, Mathiesen, Ellisiv B., Løchen, Maja Lisa, Wilsgaard, Tom, Ingelsson, Erik, Sundström, Johan, Lind, Lars, Lannfelt, Lars, Gaziano, J. Michael, Stampfer, Meir, Ridker, Paul M., Ulmer, Hanno, Diem, Günter, Concin, Hans, Tosetto, Alberto, Rodeghiero, Francesco, Marmot, Michael, Clarke, Robert, Collins, Rory, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Buring, Julie, Cobbe, Stuart, Robertson, Michele, He, Yao, Ibañez, Alejandro Marin, Feskens, Edith, Kromhout, Daan, Walker, Matthew, Watson, Sarah, Di Angelantonio, Emanuele, Erqou, Sebhat, Kaptoge, Stephen, Lewington, Sarah, Orfei, Lia, Pennells, Lisa, Perry, Philip L., Ray, Kausik K., Sarwar, Nadeem, Alexander, Myriam, Thompson, Alexander, Thompson, Simon G., Wensley, Frances, White, Ian R., Wood, Angela M., Danesh, John, Tipping, Robert W., Ford, Charles E., Simpson, Lara M., Walldius, Göran, Jungner, Ingmar, Folsom, Aaron R., Chambless, Lloyd, Panagiotakos, Demosthenes, Pitsavos, Christos, Chrysohoou, Christina, Stefanadis, Christodoulos, Goldbourt, Uri, Benderly, Michal, Tanne, David, Whincup, Peter, Wannamethee, S. Goya, Morris, Richard W., Kiechl, Stefan, Willeit, Johann, Santer, Peter, Mayr, Agnes, Wald, Nicholas, Ebrahim, Shah, Lawlor, Debbie, Yarnell, John, Gallacher, John, Casiglia, Edoardo, Tikhonoff, Valérie, Nietert, Paul J., Sutherland, Susan E., Bachman, David L., Cushman, Mary, Psaty, Bruce M., Tracy, Russ, Tybjærg-Hansen, Anne, Nordestgaard, Børge G., Frikke-Schmidt, Ruth, Kamstrup, Pia R., Giampaoli, Simona, Palmieri, Luigi, Panico, Salvatore, Vanuzzo, Diego, Pilotto, Lorenza, De La Cámara, Agustín Gómez, Gómez Gerique, Juan A., Simons, Leon, McCallum, John, Friedlander, Yechiel, Fowkes, F. Gerry R., Lee, Amanda, Smith, Felicity B., Taylor, James, Guralnik, Jack M., Phillips, Caroline L., Wallace, Robert B., Blazer, Dan G., Brenner, Hermann, Raum, Elke, Müller, Heiko, Rothenbacher, Dietrich, Jansson, Jan Håkan, Wennberg, Patrik, Nissinen, Aulikki, Donfrancesco, Chiara, Salomaa, Veikko, Harald, Kennet, Jousilahti, Pekka, Vartiainen, Erkki, Woodward, Mark, D’Agostino, Ralph B., Wolf, Philip A., Vasan, Ramachandran S., Pencina, Michael J., Bladbjerg, Else Marie, Jørgensen, Torben, Møller, Lars, Jespersen, Jørgen, Dankner, Rachel, Chetrit, Angela, Lubin, Flora, Rosengren, Annika, Wilhelmsen, Lars, Lappas, Georgios, Eriksson, Henry, Björkelund, Cecilia, Lissner, Lauren, Bengtsson, Calle, Cremer, Peter, Nagel, Dorothea, Tilvis, Reijo S., Strandberg, Timo E., Rodriguez, Beatriz, Dekker, Jacqueline, Nijpels, G., Stehouwer, Coen D.A., Rimm, Eric, Pai, Jennifer K., Sato, Shinichi, Iso, Hiroyasu, Kitamura, Akihiko, Noda, Hiroyuki, Salonen, Jukka T., Nyyssönen, Kristiina, Tuomainen, Tomi Pekka, Deeg, Dorly J.H., Poppelaars, Jan L., Hedblad, Bo, Berglund, Göran, Engström, Gunnar, Verschuren, W. M.M., Blokstra, Anneke, Döring, Angela, Koenig, Wolfgang, Meisinger, Christa, Mraz, Wilfried, Bueno-De-Mesquita, H. Bas, Kuller, Lewis H., Grandits, Greg, Selmer, Randi, Tverdal, Aage, Nystad, Wenche, Gillum, R. F., Mussolino, Michael, Hankinson, Sue, Manson, Jo Ann E., Cooper, Jackie A., Bauer, Kenneth A., Naito, Yoshihiko, Holme, Ingar, Nakagawa, Hideaki, Miura, Katsuyuki, Ducimetiere, Pierre, Jouven, Xavier, Luc, Gérald, Crespo, Carlos J., Garcia Palmieri, Mario R., Amouyel, Philippe, Arveiler, Dominique, Evans, Alun, Ferrieres, Jean, Schulte, Helmut, Assmann, Gerd, Shepherd, James, Packard, Chris J., Sattar, Naveed, Ford, Ian, Cantin, Bernard, Lamarche, Benoît, Després, Jean Pierre, Dagenais, Gilles R., Barrett-Connor, Elizabeth, Daniels, Lori B., Laughlin, Gail A., Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Trevisan, Maurizio, Witteman, Jacqueline, Kardys, Isabella, Breteler, Monique M.B., Hofman, Albert, Tunstall-Pedoe, Hugh, Tavendale, Roger, Lowe, Gordon, Ben-Shlomo, Yoav, Davey-Smith, George, Howard, Barbara V., Zhang, Ying, Best, Lyle, Umans, Jason, Onat, Altan, Njølstad, Inger, Mathiesen, Ellisiv B., Løchen, Maja Lisa, Wilsgaard, Tom, Ingelsson, Erik, Sundström, Johan, Lind, Lars, Lannfelt, Lars, Gaziano, J. Michael, Stampfer, Meir, Ridker, Paul M., Ulmer, Hanno, Diem, Günter, Concin, Hans, Tosetto, Alberto, Rodeghiero, Francesco, Marmot, Michael, Clarke, Robert, Collins, Rory, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Buring, Julie, Cobbe, Stuart, Robertson, Michele, He, Yao, Ibañez, Alejandro Marin, Feskens, Edith, Kromhout, Daan, Walker, Matthew, Watson, Sarah, Di Angelantonio, Emanuele, Erqou, Sebhat, Kaptoge, Stephen, Lewington, Sarah, Orfei, Lia, Pennells, Lisa, Perry, Philip L., Ray, Kausik K., Sarwar, Nadeem, Alexander, Myriam, Thompson, Alexander, Thompson, Simon G., Wensley, Frances, White, Ian R., Wood, Angela M., and Danesh, John

Abstract

Context Circulating concentration of lipoprotein(a) (Lp[a]), a large glycoprotein attached to a low-density lipoprotein–like particle, may be associated with risk of coronary heart disease (CHD) and stroke. Objective To assess the relationship of Lp(a) concentration with risk of major vascular and nonvascular outcomes. Study Selection Long-term prospective studies that recorded Lp(a) concentration and subsequent major vascular morbidity and/or cause-specific mortality published between January 1970 and March 2009 were identified through electronic searches of MEDLINE and other databases, manual searches of reference lists, and discussion with collaborators. Data Extraction Individual records were provided for each of 126 634 participants in 36 prospective studies. During 1.3 million person-years of follow-up, 22 076 firstever fatal or nonfatal vascular disease outcomes or nonvascular deaths were recorded, including 9336 CHD outcomes, 1903 ischemic strokes, 338 hemorrhagic strokes, 751 unclassified strokes, 1091 other vascular deaths, 8114 nonvascular deaths, and 242 deaths of unknown cause. Within-study regression analyses were adjusted for within-person variation and combined using meta-analysis. Analyses excluded participants with known preexisting CHD or stroke at baseline. Data Synthesis Lipoprotein(a) concentration was weakly correlated with several conventional vascular risk factors and it was highly consistent within individuals over several years. Associations of Lp(a) with CHD risk were broadly continuous in shape. In the 24 cohort studies, the rates of CHD in the top and bottom thirds of baseline Lp(a) distributions, respectively, were 5.6 (95% confidence interval [CI], 5.4-5.9) per 1000 personyears and 4.4 (95% CI, 4.2-4.6) per 1000 person-years. The risk ratio for CHD, adjusted for age and sex only, was 1.16 (95% CI, 1.11-1.22) per 3.5-fold higher usual Lp(a) concentration (ie, per 1 SD), and it was 1.13 (95% CI, 1.09-1.18) following further adjustmen

Published
2009

5. Sialic-Acid Content of Low-Density Lipoproteins Controls Their Binding and Uptake by Cultured Cells.

Author

Filipovic, Ivan, Schwarzmann, Güinter, Mraz, Wilfried, Wiegandt, Herbert, and Buddecke, Eckhart

Subjects
LIPOPROTEINS, SMOOTH muscle, MUSCLE cells, FIBROBLASTS, CELL culture, CULTURES (Biology)
Abstract

The (high-affinity receptor)-mediated uptake of homologous low-density (low-Q) lipoproteins by cultured human arterial smooth muscle cells or human skin fibroblasts is controlled by the sialic acid content of low-Q lipoprotein particles. This conclusion is derived from the following results. 1. Gangliosides incubated with native low-Q lipoproteins associate with low-g lipoprotein particles. Low-Q lipoproteins modified by associated GLECI, GGict, and GGict2b + GGiet³gangliosides are internalized by arterial smooth muscle cells at a rate up to 80% lower than native low-g lipoproteins or those preincubated with desialized gangliosides. 2. The inhibitory effect of gangliosides is specific for high affinity uptake and not detectable on skin fibroblasts deficient in low-g-lipoprotein receptor. 3. Desialyzed low-Q lipoproteins are internalized by smooth muscle cells up to 100% faster than native low-Q lipoproteins, the enhancement of uptake corresponding to the degree of desialization. [ABSTRACT FROM AUTHOR]

Published
1979
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results