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34 results on '"Mu, Wenqing"'

18. Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway

Author

Wen, Jincai, primary, Qin, Shuanglin, additional, Li, Yurong, additional, Zhang, Ping, additional, Zhan, Xiaoyan, additional, Fang, Mingxia, additional, Shi, Ce, additional, Mu, Wenqing, additional, Kan, Wen, additional, Zhao, Jia, additional, Hui, Siwen, additional, Hou, Manting, additional, Li, Hui, additional, Xiao, Xiaohe, additional, Xu, Guang, additional, and Bai, Zhaofang, additional

Published
2023
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19. Additional file 1 of Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation

Author

Mu, Wenqing, Xu, Guang, Wang, Zhilei, Li, Qiang, Sun, Siqiao, Qin, Qin, Li, Zhiyong, Shi, Wei, Dai, Wenzhang, Zhan, Xiaoyan, Wang, Jiabo, Bai, Zhaofang, and Xiao, Xiaohe

Abstract

Additional file 1: Supplementary information on liver injury induced by TCAs by triggering NLRP3 inflammasome activation. Fig. S1. Cell viability of BMDMs administrated with nortriptyline was assessed using CellTiter-Glo Assay, which is according to quantitation of ATP. Fig. S2. Tricyclic antidepressantnortriptyline triggers the inflammasome activation in the absence of agonists.LPS-primed BMDMs were treated with carbamazepine and nortriptyline for 12 h or treated with them for 1 h followed by ATP stimulation, respectively. Western blotting was used to assess the expression of caspase-1 and IL-1β in SN. Fig. S3. Nortriptyline has no effect on Ca2+ mobilization.LPS-primed BMDMs were pretreated with EDTAand then stimulated with nortriptyline. Western blotting was used to assess the expression of caspase-1 in SN. Fig. S4. Nortriptyline activates NLRP3 inflammasome by inducing the accumulation of mtROS.LPS-primed BMDMs were pretreated with NACfor 1 h and then treated with nortriptyline for 6 h. The content of mtROSwas measured by flow cytometry. Western blotting was used to assess the expression of IL-1β and caspase-1 in cell SN as well as pro-IL-1β, pro-caspase-1, and NLRP3in WCL. The level of caspase-1activity. The levels of IL-1βand TNF-αin SN using ELISA. Data are presented as mean ± SEM; *P < 0.05, ***P < 0.001; One-Way ANOVA followed by Dunnett's post hoc test. Fig. S5. Multiple TCAs specifically trigger the aberrant activation of NLRP3 inflammasome.LPS-primed BMDMs were pretreated with MCC950 and then stimulated with Imi, Ami, Pro, and Nor for 12 h, the levels of IL-1βand TNF-αwere detected by ELISA kits.WT and Nlrp3-/- BMDMs were primed with LPS and then stimulated with Imi, Ami, Pro and Nor, the levels of IL-1βand TNF-αwere evaluated by ELISA kits. Data are expressed as the mean ± SEM,; *P < 0.05, **P < 0.01, ***P < 0.001 vs. the control; ns, not significant; unpaired Student’s t-testfollowed by the Dunnett's post hoc test. Fig. S6. Multiple TCAs induce the NLRP3 inflammasome activation by triggering upstream signaling events.LPS-primed BMDMs were pretreated with MCC950, NAC, and KCl for 1 h followed by these TCAs stimulation, respectively. Western blotting was used to assess the expression of caspase-1in SN. Fig. S7. Nortriptyline directly triggered activation of the NLRP3 inflammasome in both hepatocytes and Kupffer cells.LPS-primed BMDMs and hepatocytes were pretreated with MCC950 and then stimulated with nortriptyline for 12 h. The levels of IL-1β in SN were detected using ELISA kits.BMDMs and Kupffer cells were primed with LPS and then pretreated with MCC950 followed by nortriptyline stimulation for 12 h. The levels of IL-1β in SN were detected using ELISA kits. Data are presented as the mean ± SEM; ***P < 0.001; One-Way ANOVA followed by the Dunnett's post hoc test. Fig. S8. Nortriptyline induces IDILI by triggering the activation of NLRP3 inflammasome.Female WT C57BL/6 mice were pretreated with LPSand then treated with different doses of nortriptyline. The serum levels of TNF-α were detected by ELISA kits.WT or Nlrp3-/- mice were pretreated with LPS and then treated with nortriptyline. ELISA kits were used to determine the levels of IL-6and TNF-αin mouse sera. Data are shown as the mean ± SEM; ***P < 0.001; ns, not significant. Statistics differences were analyzed using an unpaired Student’s t-test.

Published
2023
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22. Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I

Author

Fang, Zhi-e, primary, Wang, Chunyu, additional, Niu, Ming, additional, Liu, Tingting, additional, Ren, Lutong, additional, Li, Qiang, additional, Li, Zhiyong, additional, Wei, Ziying, additional, Lin, Li, additional, Mu, Wenqing, additional, Gao, Yuan, additional, Xiao, Xiaohe, additional, and Bai, Zhaofang, additional

Published
2022
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23. Tanshinone I Specifically Suppresses NLRP3 Inflammasome Activation by Disrupting the Association of NLRP3 and ASC

Author

Zhao, Jia, primary, Liu, Hongbin, additional, Hong, Zhixian, additional, Luo, Wei, additional, Mu, Wenqing, additional, Hou, Xiaorong, additional, Xu, Guang, additional, Fang, Zhie, additional, Ren, Lutong, additional, Liu, Tingting, additional, Li, Qiang, additional, Wen, Jincai, additional, Shi, Wei, additional, Wei, Ziying, additional, Hui, Siwen, additional, Wang, Jiabo, additional, Guo, Yuming, additional, Zhao, Xu, additional, Zou, Wenjun, additional, Yang, Yongping, additional, Zhao, Jun, additional, Xiao, Xiaohe, additional, Bai, Zhaofang, additional, and Zhan, Xiaoyan, additional

Published
2022
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25. Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress

Author

Dai, Wenzhang, primary, Qin, Qin, additional, Li, Zhiyong, additional, Lin, Li, additional, Li, Ruisheng, additional, Fang, Zhie, additional, Han, Yanzhong, additional, Mu, Wenqing, additional, Ren, Lutong, additional, Liu, Tingting, additional, Zhan, Xiaoyan, additional, Xiao, Xiaohe, additional, and Bai, Zhaofang, additional

Published
2021
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26. Corrigendum: The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis via Modulating Multiple Signaling Pathways in Mice

Author

Ai, Yongqiang, primary, Shi, Wei, additional, Zuo, Xiaobin, additional, Sun, Xiaoming, additional, Chen, Yuanyuan, additional, Wang, Zhilei, additional, Li, Ruisheng, additional, Song, Xueai, additional, Dai, Wenzhang, additional, Mu, Wenqing, additional, Ding, Kaixin, additional, Li, Zhiyong, additional, Li, Qiang, additional, Xiao, Xiaohe, additional, Zhan, Xiaoyan, additional, and Bai, Zhaofang, additional

Published
2021
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27. The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice

Author

Ai, Yongqiang, primary, Shi, Wei, additional, Zuo, Xiaobin, additional, Sun, Xiaoming, additional, Chen, Yuanyuan, additional, Wang, Zhilei, additional, Li, Ruisheng, additional, Song, Xueai, additional, Dai, Wenzhang, additional, Mu, Wenqing, additional, Ding, Kaixin, additional, Li, Zhiyong, additional, Li, Qiang, additional, Xiao, Xiaohe, additional, Zhan, Xiaoyan, additional, and Bai, Zhaofang, additional

Published
2021
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33. Estimation of groundwater discharge and associated chemical fluxes into Poyang Lake, China: approaches using stable isotopes (δD and δ18O) and radon.

Author

Liao, Fu, Wang, Guangcai, Shi, Zheming, Cheng, Guoqiang, Kong, Qingmin, Mu, Wenqing, and Guo, Liang

Subjects
GROUNDWATER, CHEMICAL flux, STABLE isotopes, RADON
Abstract

Poyang Lake is the largest freshwater lake in China and is well known for its ecological and economic importance. Understanding the contribution of groundwater to Poyang Lake is important for the lake’s protection and management. In this study, stable isotopes (δD and δ18O), 222Rn measurements, and corresponding models (222Rn and 18O mass balance models) were employed to evaluate the groundwater discharge and associated chemical inputs to Poyang Lake. The results showed that the distribution of δ18O in the lake water reflects the groundwater discharge into the lake. The groundwater discharge estimated using the 222Rn mass balance model was in reasonable agreement with the groundwater discharge derived from the 18O mass balance model. The 222Rn mass balance model showed that the groundwater discharge rate was 24.18 ± 6.85 mm/d with a groundwater discharge flux of (2.24 ± 0.63) × 107 m3/d, which accounts for 6.52-11.14% of river-water input in the Poyang Lake area. The groundwater discharge flux estimated using the 18O mass balance model was 3.17 × 107 m3/d, and the average groundwater discharge rate was 26.62 mm/d. The estimated groundwater discharge was used to estimate the associated chemical fluxes. It was found that groundwater-derived heavy metals such as iron and manganese are potential threats to the lake ecological system because of their large inputs from groundwater discharge. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity.

Author

Yang H, Zhan X, Zhao J, Shi W, Liu T, Wei Z, Li H, Hou X, Mu W, Chen Y, Zheng C, Wang Z, Wei S, Xiao X, and Bai Z

Abstract

With the advancing comprehension of immunology, an increasing number of immunotherapies are being explored and implemented in the field of cancer treatment. The cGAS-STING pathway, a crucial element of the innate immune response, has been identified as pivotal in cancer immunotherapy. We evaluated the antitumor effects of Schisandra chinensis lignan component Schisandrin C (SC) in 4T1 and MC38 tumor-bearing mice, and studied the enhancing effects of SC on the cGAS-STING pathway and antitumor immunity through RNA sequencing, qRT-PCR, and flow cytometry. Our findings revealed that SC significantly inhibited tumor growth in models of both breast and colon cancer. This suppression of tumor growth was attributed to the activation of type I IFN response and the augmented presence of T cells and NK cells within the tumor. Additionally, SC markedly promoted the cGAS-STING pathway activation induced by cisplatin. In comparison to cisplatin monotherapy, the combined treatment of SC and cisplatin exhibited a greater inhibitory effect on tumor growth. The amplified chemotherapeutic efficacy was associated with an enhanced type I IFN response and strengthened antitumor immunity. SC was shown to reduce tumor growth and increase chemotherapy sensitivity by enhancing the type I IFN response activation and boosting antitumor immunity, which enriched the research into the antitumor immunity of S. chinensis and laid a theoretical basis for its application in combating breast and colon cancer., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yang, Zhan, Zhao, Shi, Liu, Wei, Li, Hou, Mu, Chen, Zheng, Wang, Wei, Xiao and Bai.)

Published
2024
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