32 results on '"Muñana, K R"'
Search Results
2. The pharmacokinetics of midazolam after intravenous, intramuscular, and rectal administration in healthy dogs
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Schwartz, M., Muñana, K. R., Nettifee-Osborne, J. A., Messenger, K. M., and Papich, M. G.
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- 2013
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3. The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes
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Crook, K. I., Early, P. J., Messenger, K. M., Muñana, K. R., Gallagher, R., and Papich, M. G.
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- 2013
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4. Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology
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Early, P. J., primary, Crook, K. I., additional, Williams, L. M., additional, Davis, E. G., additional, Muñana, K. R., additional, Papich, M. G., additional, and Messenger, K. M., additional
- Published
- 2016
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5. Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology.
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Early, P. J., Crook, K. I., Williams, L. M., Davis, E. G., Muñana, K. R., Papich, M. G., and Messenger, K. M.
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CYTARABINE ,DRUG administration ,ENCEPHALOMYELITIS ,LABORATORY dogs ,BLOOD plasma ,ETIOLOGY of diseases ,INTRAVENOUS therapy ,THERAPEUTICS - Abstract
The objective of this study was to evaluate the plasma and serum concentrations of cytarabine (CA) administered via constant rate infusion (CRI) in dogs with meningoencephalomyelitis of unknown etiology (MUE). Nineteen client-owned dogs received a CRI of CA at a dose of 25 mg/m
2 /h for 8 h as treatment for MUE. Dogs were divided into four groups, those receiving CA alone and those receiving CA in conjunction with other drugs. Blood samples were collected at 0, 1, 8, and 12 h after initiating the CRI. Plasma ( n = 13) and serum ( n = 11) cytarabine concentrations were measured by high-pressure liquid chromatography. The mean peak concentration ( CMAX ) and area under the curve (AUC) after CRI administration were 1.70 ± 0.66 μg/mL and 11.39 ± 3.37 h·μg/mL, respectively, for dogs receiving cytarabine alone, 2.36 ± 0.35 μg/mL and 16.91 + 3.60 h·μg/mL for dogs administered cytarabine and concurrently on other drugs. Mean concentrations for all dogs were above 1.0 μg/mL at both the 1- and 8-h time points. The steady-state achieved with cytarabine CRI produces a consistent and prolonged exposure in plasma and serum, which is likely to produce equilibrium between blood and the central nervous system in dogs with a clinical diagnosis of MUE. Other medications commonly used to treat MUE do not appear to alter CA concentrations in serum and plasma. [ABSTRACT FROM AUTHOR]- Published
- 2017
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6. The pharmacokinetics of midazolam after intravenous, intramuscular, and rectal administration in healthy dogs
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Schwartz, M., primary, Muñana, K. R., additional, Nettifee-Osborne, J. A., additional, Messenger, K. M., additional, and Papich, M. G., additional
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- 2012
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7. The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes
- Author
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Crook, K. I., primary, Early, P. J., additional, Messenger, K. M., additional, Muñana, K. R., additional, Gallagher, R., additional, and Papich, M. G., additional
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- 2012
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8. Toxoplasma gondii-specific antibodies in the aqueous humor of cats with toxoplasmosis
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Chavkin, M. J., primary, Lappin, M. R., additional, Powell, C. C., additional, Cooper, C. M., additional, Muñana, K. R., additional, and Howard, L. H., additional
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- 1994
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9. The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital.
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Moore, S. A., Muñana, K. R., Papich, M. G., and Nettifee-Osborne, J. A.
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PHARMACOKINETICS , *PHENOBARBITAL , *DRUG administration , *DRUG dosage , *CHROMATOGRAPHIC analysis - Abstract
Moore, S.A., Muñana, K.R., Papich, M.G., Nettifee-Osborne, J.A. The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital. J. vet. Pharmacol. Therap., 31-34. Levetiracetam (LEV) is a commonly used add-on medication in dogs with refractory epilepsy. The objective of this study was to determine if the pharmacokinetics of LEV are altered by concurrent administration of phenobarbital (PB). Six healthy dogs received a single oral dose of LEV (16.7-27.8 mg/kg). Blood samples were collected at baseline and intermittently for 24 h. The study was repeated after the dogs received oral PB (2.0-3.3 mg/kg) twice daily for 21 days. Plasma LEV levels were evaluated by high pressure liquid chromatography, and data analyzed using a compartmental model. Compared with values determined when LEV was administered alone, concurrent administration of PB resulted in a decrease in LEV peak concentration (C) from 32.39 ± 6.76 to 18.22 ± 8.97 ( P = 0.0071), a decrease in elimination half-life ( T) from 3.43 ± 0.47 to 1.73 ± 0.22 ( P = 0.0005), and an increase in oral clearance from 124.93 ± 26.93 to 252.99 ± 135.43 ml/h/kg ( P < 0.0001). Concurrent PB administration significantly alters the pharmacokinetics of LEV in the dog, indicating that dosage adjustments might be necessary when the drug is administered with PB. [ABSTRACT FROM AUTHOR]
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- 2011
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10. Prevalence of Urinary Tract Infection in Dogs after Surgery for Thoracolumbar Intervertebral Disc Extrusion.
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Olby, N. J., MacKillop, E., Cerda-Gonzalez, S., Moore, S., Muñana, K. R., Grafinger, M., Osborne, J. A., and Vaden, S. L.
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URINARY tract infections ,SPINAL cord injuries ,SPINAL surgery ,DOG diseases ,URINARY incontinence ,URINALYSIS ,URINATION ,HEMATURIA - Abstract
Background: Urinary tract infection (UTI) is a common complication in people with spinal cord injury (SCI). Dogs with acute intervertebral disc extrusion (IVDE) have similar risk factors for UTI when compared with human SCI patients and have a high perioperative prevalence of UTI. Objectives: Determine the prevalence of UTI in dogs for 3 months after surgery for thoracolumbar IVDE and identify risk factors for development of UTI. Animals: Twenty-five dogs treated surgically for 26 acute disc extrusions. Methods: Prospective study. Urinalysis and urine culture were performed perioperatively. At home, owners monitored urine with dipsticks every 48 hours for 1 month then once a week until 3 months. Dogs returned for assessment of motor function, urinalysis, and urine culture at 1 and 3 months after surgery. Presence of UTI over the 3-month period was correlated to potential risk factors. Results: Ten dogs (38%) developed 12 UTIs over the 3-month period, with the majority occurring between weeks 1 and 6; 60% of the UTIs were occult. Hematuria in the absence of pyuria or UTI was a common finding in the perioperative period. Sex, breed, and ambulatory status influenced the risk of developing a UTI. Conclusions and Clinical Importance: There is a high prevalence of UTIs, many of which are occult, in the 3 months after surgery for thoracolumbar IVDE. These dogs should be routinely monitored for UTI with urine culture regardless of urinalysis results. [ABSTRACT FROM AUTHOR]
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- 2010
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11. Placebo Effect in Canine Epilepsy Trials.
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Muñana, K. R., Zhang, D., and Patterson, E. E.
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PLACEBOS , *EPILEPSY , *DOG diseases , *CLINICAL trials , *THERAPEUTICS - Abstract
Background: The placebo effect is a well-recognized phenomenon in human medicine; in contrast, little information exists on the effect of placebo administration in veterinary patients. Hypothesis: Nonpharmacologic therapeutic effects play a role in response rates identified in canine epilepsy trials. Animals: Thirty-four dogs with epilepsy. Methods: Meta-analysis of the 3 known prospective, placebo-controlled canine epilepsy trials. The number of seizures per week was compiled for each dog throughout their participation in the trial. Log-linear models were developed to evaluate seizure frequency during treatment and placebo relative to baseline. Results: Twenty-two of 28 (79%) dogs in the study that received placebo demonstrated a decrease in seizure frequency compared with baseline, and 8 (29%) could be considered responders, with a 50% or greater reduction in seizures. For the 3 trials evaluated, the average reduction in seizures during placebo administration relative to baseline was 26% ( P= .0018), 29% ( P= .17), and 46% ( P= .01). Conclusions and Clinical Importance: A positive response to placebo administration, manifesting as a decrease in seizure frequency, can be observed in epileptic dogs. This is of importance when evaluating open label studies in dogs that aim to assess efficacy of antiepileptic drugs, as the reported results might be overstated. Findings from this study highlight the need for more placebo-controlled trials in veterinary medicine. [ABSTRACT FROM AUTHOR]
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- 2010
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12. Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion.
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Castel A, Olby NJ, Mariani CL, Muñana KR, and Early PJ
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- Animals, Disease Progression, Dog Diseases diagnostic imaging, Dogs, Female, Intervertebral Disc Degeneration diagnostic imaging, Intervertebral Disc Degeneration pathology, Intervertebral Disc Displacement diagnostic imaging, Intervertebral Disc Displacement pathology, Magnetic Resonance Imaging veterinary, Male, Myelography veterinary, Retrospective Studies, Spinal Cord Diseases mortality, Spinal Cord Diseases pathology, Tomography, X-Ray Computed veterinary, Dog Diseases pathology, Intervertebral Disc Degeneration veterinary, Intervertebral Disc Displacement veterinary, Spinal Cord Diseases veterinary
- Abstract
Background: Progressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited., Objective: To describe the onset and progression of clinical signs of PMM in a large case cohort., Animals: Fifty-one dogs, 18 with histopathologically confirmed PMM, 33 presumptively diagnosed based on clinical signs and diagnostic imaging., Methods: Retrospective study. Dogs with confirmed IVDE and either a histopathologic diagnosis of PMM or a high clinical suspicion were identified by medical record search. Data on nature and progression of signs were extracted., Results: Twenty-four of 51 dogs were Dachshunds. T12-T13 was the most common site of disc extrusion (12 of 56), and 18 of 55 of mid-to-caudal lumbar discs (between L3 and L6) were affected. Onset of PMM signs ranged from present at first evaluation (17/51) to 5 days after presentation, with 25 of 51 cases developing signs within 48 hours. Progression of signs from onset of PMM to euthanasia or death, excluding 7 cases euthanized at presentation, ranged from 1 to 13 days with 23 being euthanized within 3 days. Nonspecific systemic signs were documented in 30 of 51 dogs., Conclusion and Clinical Importance: The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days. However, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. Mid-to-caudal lumbar discs might be associated with an increased risk of PMM., (Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
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- 2017
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13. Associations Between Anesthetic Variables and Functional Outcome in Dogs With Thoracolumbar Intervertebral Disk Extrusion Undergoing Decompressive Hemilaminectomy.
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Fenn J, Laber E, Williams K, Rousse CA, Early PJ, Mariani CL, Muñana KR, De Decker S, Volk HA, and Olby NJ
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- Anesthesia, General adverse effects, Anesthesia, General methods, Animals, Bradycardia chemically induced, Bradycardia veterinary, Decompression, Surgical methods, Dogs, Female, Hypotension chemically induced, Hypotension veterinary, Intervertebral Disc Displacement surgery, Laminectomy methods, Male, Retrospective Studies, Thoracic Vertebrae surgery, Treatment Outcome, Anesthesia, General veterinary, Decompression, Surgical veterinary, Dog Diseases surgery, Intervertebral Disc Displacement veterinary, Laminectomy veterinary
- Abstract
Background: Outcome of acute experimental spinal cord injury is strongly associated with tissue perfusion and oxygenation. Cardiopulmonary depression could affect outcome in dogs undergoing general anesthesia for surgical treatment of thoracolumbar intervertebral disk extrusion (IVDE)., Hypothesis/objectives: To evaluate the effects of general anesthesia on functional outcome in dogs undergoing surgery to treat thoracolumbar IVDE., Animals: Eighty-four client-owned dogs with acute thoracolumbar IVDE treated by decompressive hemilaminectomy., Methods: Exploratory, retrospective observational study. Medical records were reviewed for clinical presentation and anesthetic monitoring variables, including duration of anesthesia and surgery, hypotension, bradycardia, temperature, and respiratory parameters. Multivariable regression tree analysis was performed to explore associations between anesthetic variables and functional outcome scores after 6 weeks, as well as return to ambulatory status., Results: Episodes of bradycardia (69%) and hypotension (57%) were frequent. Across all outcome measures, regression tree analysis highlighted functional grade at presentation as the primary determining factor, and among pain perception negative dogs, there was a possible association between increased duration of surgery and poorer outcome. In dogs with intact pain perception, duration of bradycardia, mean body temperature, and mean end-tidal carbon dioxide were highlighted., Conclusions and Clinical Importance: Exploratory statistical methods can facilitate hypothesis-generating studies to inform prospective investigations in veterinary medicine. Although the mechanism is uncertain, increased duration of surgery might be associated with poorer outcome in pain perception negative dogs with thoracolumbar IVDE., (Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
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- 2017
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14. Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial.
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Olby NJ, Vaden SL, Williams K, Griffith EH, Harris T, Mariani CL, Muñana KR, Early PJ, Platt SR, Boozer L, Giovanella C, and Longshore R
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- Administration, Oral, Animals, Anti-Infective Agents administration & dosage, Anti-Infective Agents therapeutic use, Bacteriuria complications, Bacteriuria drug therapy, Bacteriuria urine, Bacteriuria veterinary, Dogs, Female, Intervertebral Disc Displacement complications, Male, Plant Extracts administration & dosage, Prospective Studies, Single-Blind Method, Treatment Outcome, Urinary Tract Infections complications, Urinary Tract Infections drug therapy, Urinary Tract Infections urine, Dog Diseases drug therapy, Intervertebral Disc Displacement veterinary, Plant Extracts therapeutic use, Thoracic Vertebrae, Urinary Tract Infections veterinary, Vaccinium macrocarpon
- Abstract
Background: Dogs with spinal cord injury are at increased risk of developing bacteriuria due to increased residual urine volume. Cranberry extract inhibits binding of E. coli to uroepithelial cells, potentially reducing risk of bacteriuria., Hypothesis: Cranberry extract reduces risk of bacteriuria in dogs after acute TL-IVDH., Animals: Client-owned dogs with acute onset TL-IVDH causing nonambulatory status., Methods: Randomized, placebo-controlled, blinded, prospective clinical trial. Dogs with acute TL-IVDH were recruited 48 hours postoperatively and randomized to receive cranberry extract or placebo in a masked fashion. Urine cultures and neurological examinations were performed 2, 4, and 6 weeks postoperatively. The number of dogs with bacteriuria (all bacterial species) and bacteriuria (E. coli) were primary and secondary outcome measures and were evaluated using chi-squared test. Urine antiadhesion activity (AAA) was measured in a subset (N = 47) and examined in a secondary analysis evaluating additional risk factors for bacteriuria., Results: Bacteriuria was detected 17 times in 94 dogs (6 placebo, 11 cranberry, P = .12). There were 7 E. coli. positive cultures (1 placebo, 6 cranberry, P = .09). Dogs in both groups had positive urine AAA (14/21: placebo, 16/26: cranberry), and dogs with urine AAA had significantly fewer E. coli positive cultures (n = 1) than dogs without it (n = 4) (P = .047)., Conclusions and Clinical Importance: This clinical trial did not show a benefit of oral cranberry extract but had low power. Cranberry extract supplementation did not impact urine AAA, but a possible association between urine AAA and lower risk of E. coli bacteriuria was identified. Other doses could be investigated., (Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
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- 2017
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15. Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats.
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Lewis MJ, Olby NJ, Early PJ, Mariani CL, Muñana KR, Seiler GS, and Griffith EH
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- Animals, Body Size, Brain pathology, Cat Diseases pathology, Cats, Dog Diseases pathology, Dogs, Retrospective Studies, Brain diagnostic imaging, Cat Diseases diagnostic imaging, Dog Diseases diagnostic imaging, Magnetic Resonance Imaging veterinary
- Abstract
Background: Quantification of brain herniation on MRI and its immediate clinical implications are poorly described., Objectives: Define the normal position of caudal fossa structures on brain MRIs in dogs and cats utilizing morphometry, compare this to dogs and cats with caudal transtentorial herniation (CTH), foramen magnum herniation (FMH) or both identified on MRI, and investigate associations between herniation severity, clinical signs, and 24-hour outcome., Animals: Ninety-two controls (66 dogs, 26 cats), 119 cases with herniation (88 dogs, 31 cats)., Methods: Retrospective case series. The MRI database was searched for controls with normal brain anatomy and cases with brain herniation. Morphometry in controls established TTX (transtentorial to rostroventral cerebellum) to quantify CTH and FMX (caudoventral cerebellum to foramen magnum) to quantify FMH. Measurements were compared between cases and controls. Correlations with specific clinical variables and outcome were investigated., Results: Measurements in medium/large control dogs versus small dog and cat controls were significantly different (P < .001, TTX: -0.46, -0.305, -0.3, FMX: 0.695, 0.27, 0.25, respectively). 119/1564 (7.6%) cases that underwent brain imaging had brain herniation. TTX and FMX were significantly different between controls and cases with CTH or FMH (P < .001). 67/89 (75%) cases with supratentorial lesions had no signs directly attributable to herniation. 71/119 (60%) had a normal anesthetic recovery. TTX was significantly associated with 24-hour survival (P < .001)., Conclusions and Clinical Importance: Brain herniation can be quantified on MRI. Clinical signs directly attributable to brain herniation commonly are absent, and more severe CTH based on TTX is associated with a worse short-term outcome., (Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
- Published
- 2016
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16. Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations.
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Rousse CA, Olby NJ, Williams K, Harris TL, Griffith EH, Mariani CL, Muñana KR, and Early PJ
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- Acute Disease, Animals, Dog Diseases etiology, Dogs, Female, Forelimb physiology, Hindlimb physiology, Intervertebral Disc pathology, Intervertebral Disc Displacement etiology, Intervertebral Disc Displacement surgery, Male, Prospective Studies, Spinal Cord Injuries etiology, Spinal Cord Injuries surgery, Dog Diseases surgery, Intervertebral Disc surgery, Intervertebral Disc Displacement veterinary, Spinal Cord Injuries veterinary, Walking
- Abstract
Prospective data on the recovery of coordination in dogs suffering acute thoracolumbar intervertebral disc herniations (TL-IVDH) are limited. The purpose of this study was to use treadmill based and open field scores (OFS) to quantify recovery of stepping ability and forelimb, hindlimb coordination in the 6 weeks following surgical decompression of dogs with TL-IVDH. Sixty-three dogs were grouped at presentation as grades 3 (non-ambulatory paraparetic), 4 (paraplegic) or 5 (paraplegic without pain sensation) and were evaluated 2, 4, and 6 weeks post-operatively. Stepping scores and Regularity Index (RI), a measure of coordination, were calculated from treadmill walking, and an OFS incorporating supported and unsupported walking was assigned. Outcomes for the three measures were compared between groups and correlation between scoring methods was assessed. Grade 3 and 4 dogs recovered ambulation by 2 weeks, reaching median stepping scores of 96 and 90% by 6 weeks, respectively. Recovery of coordination differed between groups 3 and 4 with median RI scores of 93.9% and 63%, respectively, by 6 weeks. Eight grade 5 dogs failed to recover independent ambulation by 6 weeks. Nine dogs recovered with scores that were significantly worse than the grade 3 and 4 dogs at 6 weeks for stepping score (P < 0.001) and RI (P < 0.001). OFS correlated closely with stepping and RI scores and each group was significantly different using this ordinal scale. In conclusion, recovery of coordination was incomplete in dogs that showed good recovery of stepping. The data generated could be used for clinical trial design., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
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- 2016
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17. A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation.
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Olby NJ, Muguet-Chanoit AC, Lim JH, Davidian M, Mariani CL, Freeman AC, Platt SR, Humphrey J, Kent M, Giovanella C, Longshore R, Early PJ, and Muñana KR
- Subjects
- Animals, Anti-Inflammatory Agents administration & dosage, Dogs, Female, Intervertebral Disc Displacement drug therapy, Male, Methylprednisolone Hemisuccinate administration & dosage, Nociception drug effects, Polyethylene Glycols administration & dosage, Anti-Inflammatory Agents therapeutic use, Dog Diseases drug therapy, Intervertebral Disc Displacement veterinary, Methylprednisolone Hemisuccinate therapeutic use, Polyethylene Glycols therapeutic use
- Abstract
Background: Acute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there is no proven medical treatment to counter secondary injury effects. Use of methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo-controlled, randomized, blinded trials in dogs., Hypothesis: Polyethylene glycol will improve the outcome of severe spinal cord injury caused by IVDH compared to MPSS or placebo., Animals: Client-owned dogs with acute onset of thoracolumbar IVDH causing paralysis and loss of nociception for <24 hours., Methods: Dogs were randomized to receive MPSS, PEG, or placebo; drugs appeared identical and group allocation was masked. Drug administration was initiated once the diagnosis of IVDH was confirmed and all dogs underwent hemilaminectomy. Neurologic function was assessed 2, 4, 8, and 12 weeks postoperatively using an open field gait score (OFS) as the primary outcome measure. Outcomes were compared by the Wilcoxon rank sum test., Results: Sixty-three dogs were recruited and 47.6% recovered ambulation. 17.5% developed progressive myelomalacia but there was no association with group. There was no difference in OFS among groups. Although full study power was not reached, conditional power analyses indicated the futility of continued case recruitment., Conclusions: This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis., (Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
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- 2016
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18. Effect of chronic administration of phenobarbital, or bromide, on pharmacokinetics of levetiracetam in dogs with epilepsy.
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Muñana KR, Nettifee-Osborne JA, and Papich MG
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- Animals, Anticonvulsants administration & dosage, Anticonvulsants pharmacokinetics, Anticonvulsants therapeutic use, Area Under Curve, Bromides administration & dosage, Dog Diseases blood, Dog Diseases metabolism, Dogs, Epilepsy blood, Epilepsy drug therapy, Half-Life, Levetiracetam, Phenobarbital administration & dosage, Piracetam administration & dosage, Piracetam pharmacokinetics, Piracetam therapeutic use, Bromides therapeutic use, Dog Diseases drug therapy, Epilepsy veterinary, Phenobarbital therapeutic use, Piracetam analogs & derivatives
- Abstract
Background: Levetiracetam (LEV) is a common add-on antiepileptic drug (AED) in dogs with refractory seizures. Concurrent phenobarbital administration alters the disposition of LEV in healthy dogs., Hypothesis/objectives: To evaluate the pharmacokinetics of LEV in dogs with epilepsy when administered concurrently with conventional AEDs., Animals: Eighteen client-owned dogs on maintenance treatment with LEV and phenobarbital (PB group, n = 6), LEV and bromide (BR group, n = 6) or LEV, phenobarbital and bromide (PB-BR group, n = 6)., Methods: Prospective pharmacokinetic study. Blood samples were collected at 0, 1, 2, 4, and 6 hours after LEV administration. Plasma LEV concentrations were determined by high-pressure liquid chromatography. To account for dose differences among dogs, LEV concentrations were normalized to the mean study dose (26.4 mg/kg). Pharmacokinetic analysis was performed on adjusted concentrations, using a noncompartmental method, and area-under-the-curve (AUC) calculated to the last measured time point., Results: Compared to the PB and PB-BR groups, the BR group had significantly higher peak concentration (Cmax ) (73.4 ± 24.0 versus 37.5 ± 13.7 and 26.5 ± 8.96 μg/mL, respectively, P < .001) and AUC (329 ± 114 versus 140 ± 64.7 and 98.7 ± 42.2 h*μg/mL, respectively, P < .001), and significantly lower clearance (CL/F) (71.8 ± 22.1 versus 187 ± 81.9 and 269 ± 127 mL/h/kg, respectively, P = .028)., Conclusions and Clinical Importance: Concurrent administration of PB alone or in combination with bromide increases LEV clearance in epileptic dogs compared to concurrent administration of bromide alone. Dosage increases might be indicated when utilizing LEV as add-on treatment with phenobarbital in dogs., (Copyright © 2015 by the American College of Veterinary Internal Medicine.)
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- 2015
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19. Association between ABCB1 genotype and seizure outcome in Collies with epilepsy.
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Muñana KR, Nettifee-Osborne JA, Bergman RL Jr, and Mealey KL
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- Animals, Anticonvulsants therapeutic use, Bromides therapeutic use, Dog Diseases drug therapy, Dogs, Epilepsy drug therapy, Epilepsy genetics, Gene Expression Regulation, Phenobarbital therapeutic use, ATP Binding Cassette Transporter, Subfamily B, Member 1 genetics, Dog Diseases genetics, Epilepsy veterinary, Genetic Predisposition to Disease, Genotype
- Abstract
Background: Medically refractory seizures are an important problem in both humans and dogs with epilepsy. Altered expression of ABCB1, the gene encoding for p-glycoprotein (PGP), has been proposed to play a role in drug-resistant epilepsy., Hypothesis: Heterogeneity of the ABCB1 gene is associated with seizure outcome in dogs with epilepsy., Animals: Twenty-nine Collies with epilepsy being treated with antiepileptic drugs (AEDs)., Methods: Prospective and retrospective cohort study. Dogs were classified as having a good outcome (≤ 1 seizure/month, no cluster seizures) or a poor outcome (>1 seizure/month, with or without cluster seizures) based on owner-completed questionnaire. Serum AED concentrations were measured, and ABCB1 genotyping was performed on buccal tissue samples. Association analyses were performed for genotype and seizure outcome, number of AEDs administered, serum AED concentrations, and incidence of adverse effects., Results: Fourteen dogs of 29 (48%) were homozygous for the ABCB1-1∆ mutation (M/M), 11 dogs (38%) were heterozygous (M/N), and 4 dogs (14%) had the wild-type genotype (N/N). Dogs with the M/M genotype were significantly more likely to have fewer seizures and have less AED-related sedation than M/N or N/N dogs (P = .003 and P = .001, respectively). Serum phenobarbital and bromide concentrations did not differ between groups, but the M/N and N/N groups received a larger number of AEDs than the M/M group (P = .014)., Conclusions and Clinical Importance: ABCB1 genotype is associated with seizure outcome in Collies with epilepsy. This cannot be attributed to differences in PGP function, but might be because of intrinsic variations in seizure severity among phenotypes., (Copyright © 2012 by the American College of Veterinary Internal Medicine.)
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- 2012
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20. Evaluation of levetiracetam as adjunctive treatment for refractory canine epilepsy: a randomized, placebo-controlled, crossover trial.
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Muñana KR, Thomas WB, Inzana KD, Nettifee-Osborne JA, McLucas KJ, Olby NJ, Mariani CJ, and Early PJ
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- Animals, Anticonvulsants adverse effects, Anticonvulsants blood, Cross-Over Studies, Dog Diseases blood, Dogs, Double-Blind Method, Epilepsy blood, Epilepsy drug therapy, Female, Levetiracetam, Male, Piracetam administration & dosage, Piracetam adverse effects, Piracetam blood, Quality of Life, Seizures blood, Seizures drug therapy, Statistics, Nonparametric, Anticonvulsants administration & dosage, Dog Diseases drug therapy, Epilepsy veterinary, Piracetam analogs & derivatives, Seizures veterinary
- Abstract
Background: There is little evidence-based information available to guide treatment of refractory epilepsy in dogs. The antiepileptic drug levetiracetam (LEV) is administered to dogs, although its safety and efficacy are unknown., Objective: To evaluate the safety and efficacy of LEV as adjunctive therapy for refractory epilepsy in dogs., Animals: Thirty-four client-owned dogs with idiopathic epilepsy., Methods: Randomized, blinded trial involving dogs resistant to phenobarbital and bromide. Dogs received LEV (20 mg/kg PO q8h) or placebo for 16 weeks, and after a 4-week washout were crossed over to the alternate treatment for 16 weeks. Owners kept records on seizure frequency and adverse events. Hemogram, chemistry profile, urinalysis, and serum antiepileptic drug concentrations were evaluated at established intervals., Results: Twenty-two (65%) dogs completed the study. Weekly seizure frequency during the 1st treatment period decreased significantly during LEV administration relative to baseline (1.9 ± 1.9 to 1.1 ± 1.3, P = .015). The reduction in seizures with LEV was not significant when compared to placebo (1.1 ± 1.3 versus 1.5 ± 1.7, P = .310). The most common adverse event was ataxia, with no difference in incidence between LEV and placebo (45 versus 18%, P = .090). No changes in laboratory parameters were identified and owners reported an improved quality of life (QOL) with LEV compared to placebo (QOL score 32.7 ± 4.3 versus 29.4 ± 4.5, P = .028)., Conclusions and Clinical Importance: Adjunctive treatment with LEV appears safe in epileptic dogs. Efficacy of LEV over placebo was not demonstrated, although the power of the study was limited. Further evaluation of LEV as treatment for epilepsy in dogs is warranted., (Copyright © 2012 by the American College of Veterinary Internal Medicine.)
- Published
- 2012
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21. Development of a functional scoring system in dogs with acute spinal cord injuries.
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Olby NJ, De Risio L, Muñana KR, Wosar MA, Skeen TM, Sharp NJ, and Keene BW
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- Animals, Dogs, Gait physiology, Hindlimb physiopathology, Intervertebral Disc Displacement physiopathology, Intervertebral Disc Displacement veterinary, Observer Variation, Paraplegia etiology, Paraplegia veterinary, Reproducibility of Results, Severity of Illness Index, Spinal Cord Diseases complications, Spinal Cord Diseases physiopathology, Statistics, Nonparametric, Videotape Recording, Dog Diseases physiopathology, Spinal Cord Diseases veterinary
- Abstract
Objectives: To develop and compare the reliability of 2 methods of scoring pelvic limb gait in dogs recovering from thoracolumbar spinal cord injuries and to use this scoring system to determine the rate and level of functional recovery of dogs with acute thoracolumbar intervertebral disk herniations., Animals: 46 dogs with spinal cord injuries resulting from intervertebral disk herniations., Procedure: Dogs' gaits were videotaped at different time intervals after injury. In phase 1 of the study, the stages of recovery of pelvic limb function were identified, and a numeric scoring system was devised to reflect that recovery. In phase 2, pelvic limb gait was scored by different observers, using a numeric and a visual analog scale. Intra- and interobserver coefficients of variability of both methods were compared. In phase 3, pelvic limb function was scored, using the numeric scale at various intervals after acute thoracolumbar disk herniations., Results: The numeric scale was significantly more reliable than the visual analog scale when both intra- and interobserver coefficients of variability were evaluated. Dogs that were paraplegic with no deep pain sensation recovered at different rates during the first 3 months, whereas dogs that were paraplegic with deep pain sensation typically recovered within 1 month of injury., Conclusions: Pelvic limb gait of dogs recovering from thoracolumbar spinal cord injuries can be reliably quantified, using a numeric scale. This scale will facilitate the performance of clinical trials aimed at improving the outcome of acute spinal cord injuries.
- Published
- 2001
- Full Text
- View/download PDF
22. Predictors of outcome after dorsal decompressive laminectomy for degenerative lumbosacral stenosis in dogs: 69 cases (1987-1997).
- Author
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De Risio L, Sharp NJ, Olby NJ, Muñana KR, and Thomas WB
- Subjects
- Animals, Dogs, Female, Follow-Up Studies, Lumbosacral Region surgery, Male, Medical Records, Prognosis, Retrospective Studies, Spinal Stenosis complications, Spinal Stenosis surgery, Surveys and Questionnaires, Treatment Outcome, Urinary Incontinence complications, Urinary Incontinence veterinary, Decompression, Surgical veterinary, Dog Diseases surgery, Laminectomy veterinary, Spinal Stenosis veterinary
- Abstract
Objective: To identify predictive factors of long-term outcome after dorsal decompressive laminectomy for the treatment of degenerative lumbosacral stenosis (DLSS) in dogs., Design: Retrospective study., Sample Population: 69 client-owned dogs., Procedure: Medical records of dogs that had undergone dorsal laminectomy at North Carolina State University and the University of Tennessee between 1987 and 1997 were reviewed. Dogs with diskospondylitis, traumatic lesions, or neoplasia of the lumbosacral region were excluded. All dogs had evidence of cauda equina compression on myelography, epidurography, computed tomography, or magnetic resonance imaging, along with subsequent confirmation of the lesion at surgery. Follow-up was performed by telephone inquiries to the referring veterinarian, the owner, or both, using a detailed questionnaire., Results: The outcome was excellent or good in 54 of 69 (78%) dogs over a mean follow-up period of 38+/-22 months. Five of these 54 dogs had been incontinent for a median of 2 weeks prior to surgery. Six of the 15 dogs with a poor outcome had been incontinent for a median of 8 weeks before surgery. A significant correlation was detected between the presence of urinary and fecal incontinence prior to surgery and outcome. When duration of signs was considered, urinary incontinence was the only variable that significantly affected outcome., Conclusions and Clinical Relevance: Decompressive laminectomy is an effective treatment for DLSS, although dogs with urinary or fecal incontinence have a worse prognosis than dogs that are continent before surgery. Chronic urinary incontinence is a predictor of poor outcome for dogs with DLSS.
- Published
- 2001
- Full Text
- View/download PDF
23. Risk factors for development of status epilepticus in dogs with idiopathic epilepsy and effects of status epilepticus on outcome and survival time: 32 cases (1990-1996).
- Author
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Saito M, Muñana KR, Sharp NJ, and Olby NJ
- Subjects
- Animals, Anticonvulsants therapeutic use, Body Weight, Dog Diseases diagnosis, Dog Diseases mortality, Dogs, Epilepsy complications, Epilepsy mortality, Epilepsy veterinary, Female, Male, Records veterinary, Retrospective Studies, Risk Factors, Seizures complications, Seizures mortality, Seizures veterinary, Status Epilepticus etiology, Status Epilepticus mortality, Treatment Outcome, Dog Diseases etiology, Status Epilepticus veterinary
- Abstract
Objective: To identify risk factors for episodes of status epilepticus (SE) in dogs with idiopathic epilepsy and determine how SE affects long-term outcome and survival time., Design: Retrospective study., Animals: 32 dogs with idiopathic epilepsy., Procedure: Information on signalment, seizure onset, initiation of treatment, anticonvulsants administered, number of episodes of SE, overall seizure control, and long-term outcome was obtained from medical records and through telephone interviews. Differences between dogs that did and did not have episodes of SE were evaluated statistically., Results: 19 (59%) dogs had 1 or more episodes of SE. Body weight was the only variable significantly different between dogs that did and did not have episodes of SE. Thirteen dogs (9 that did not have episodes of SE and 4 that did) were still alive at the time of the study and were > or = 10 years old. Six of the 19 (32%) dogs that had episodes of SE died of causes directly attributed to the seizure disorder. Mean life spans of dogs that did and did not have episodes of SE were 8.3 and 11.3 years, respectively. Survival time was significantly different between groups., Conclusions and Clinical Relevance: Results suggest that a substantial percentage of dogs with idiopathic epilepsy will have episodes of SE. Dogs with greater body weights were more likely to have episodes of SE, and early appropriate seizure treatment did not appear to decrease the risk that dogs would have episodes. Most dogs with idiopathic epilepsy had an expected life span, but survival time was shorter for dogs that had episodes of SE.
- Published
- 2001
- Full Text
- View/download PDF
24. Intervertebral disk disease in 10 cats.
- Author
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Muñana KR, Olby NJ, Sharp NJ, and Skeen TM
- Subjects
- Animals, Cat Diseases diagnostic imaging, Cat Diseases pathology, Cats, Female, Intervertebral Disc, Lumbar Vertebrae, Male, North Carolina epidemiology, Radiography, Records veterinary, Retrospective Studies, Spinal Diseases diagnostic imaging, Spinal Diseases epidemiology, Spinal Diseases pathology, Cat Diseases epidemiology, Spinal Diseases veterinary
- Abstract
The medical records of 10 cats diagnosed with intervertebral disk disease were reviewed. No apparent sex or breed predilection was found. The mean age of cats in the study was 9.8 years. Clinical signs included back pain, difficulty ambulating, and incontinence. Radiographs revealed narrowed disk spaces, mineralized intervertebral disks, and evidence of extradural compression on myelography or computed tomography. All intervertebral disk herniations occurred in the thoracolumbar spine, with a peak incidence at the fourth to fifth lumbar (L4-L5) intervertebral disk space. Eight cats had Hansen's type I intervertebral disk herniation. Surgery was performed in seven cats. All cats judged to have an excellent outcome had undergone surgical decompression.
- Published
- 2001
- Full Text
- View/download PDF
25. Infection of fetal feline brain cells in culture with Bartonella henselae.
- Author
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Muñana KR, Vitek SM, Hegarty BC, Kordick DL, and Breitschwerdt EB
- Subjects
- Animals, Astrocytes microbiology, Brain cytology, Brain Diseases etiology, Cats, Cells, Cultured, DNA, Bacterial analysis, Female, Fetus microbiology, Microscopy, Electron, Pregnancy, Bartonella henselae physiology, Brain microbiology, Microglia microbiology
- Abstract
Bartonella henselae is known to cause central nervous system (CNS) disease in humans, and neurological signs have been observed in experimentally infected cats. However, the pathogenesis of CNS disease remains unclear. This study was undertaken to determine whether B. henselae infects feline fetal brain cells in vitro. Microglial-cell- and astrocyte-enriched cultures were inoculated with B. henselae. Giménez staining identified bacterial organisms within microglial cells by day 7 postinoculation. The viability of the intracellular bacteria was demonstrated by incubating cultures with gentamicin and plating cell lysate on agar. Electron microscopy identified intracellular organisms with characteristic Bartonella morphology but identified no ultrastructural abnormalities within infected microglial cells. No evidence of infection was seen in Bartonella-inoculated astrocyte cultures. These findings suggest a role for microglia in the pathogenesis of B. henselae-associated neurological disease.
- Published
- 2001
- Full Text
- View/download PDF
26. The computed tomographic appearance of acute thoracolumbar intervertebral disc herniations in dogs.
- Author
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Olby NJ, Muñana KR, Sharp NJ, and Thrall DE
- Subjects
- Animals, Diskectomy, Dog Diseases surgery, Dogs, Hematoma, Epidural, Cranial veterinary, Intervertebral Disc Displacement diagnostic imaging, Intervertebral Disc Displacement surgery, Myelography, Spinal Cord pathology, Tomography, X-Ray Computed, Dog Diseases diagnostic imaging, Intervertebral Disc Displacement veterinary
- Abstract
The appearance of herniated intervertebral disc material in the thoracolumbar vertebral canal was evaluated in 23 dogs using computed tomography (CT). The images were then compared with the myelographic and surgical findings. The normal spinal cord, outlined by epidural fat over intervertebral disc spaces, was of intermediate attenuation on transverse CT images. Herniated disc material was identified in all animals as a heterogeneous hyperattenuating extradural mass. The attenuation of the disc material increased with the degree of mineralization. In seven dogs, the herniated material was only slightly more attenuating than the spinal cord. In these dogs, small fragments of mineralized disc material and significant hemorrhage were found in the epidural space at surgery. In dogs with a long standing history of disc herniations, disc material identified in the vertebral canal had a more hyperattenuating and homogeneous appearance than recently herniated disc material. We conclude that mineralized, herniated disc material and hemorrhage can be identified quickly and safely in dogs using CT.
- Published
- 2000
- Full Text
- View/download PDF
27. Chronic and acute compressive spinal cord lesions in dogs due to intervertebral disc herniation are associated with elevation in lumbar cerebrospinal fluid glutamate concentration.
- Author
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Olby NJ, Sharp NJ, Muñana KR, and Papich MG
- Subjects
- Acute Disease, Animals, Chronic Disease, Dogs, Lumbar Vertebrae, Lumbosacral Region, Osmolar Concentration, Reference Values, Thoracic Vertebrae, Glutamic Acid cerebrospinal fluid, Intervertebral Disc Displacement complications, Spinal Cord Injuries cerebrospinal fluid, Spinal Cord Injuries etiology
- Abstract
Acute injury to the central nervous system initiates a series of biochemical events that cause secondary tissue damage. The accumulation of excessive concentrations of glutamate in the extracellular space causes excitotoxic damage, and is incriminated as a mediator of this secondary tissue damage. The aim of this study was to measure the concentration of glutamate in cerebrospinal fluid (CSF) obtained from the cerebellomedullary cistern and lumbar subarachnoid space in dogs with acute and chronic compressive injuries of the cervical and thoracolumbar spinal cord, and to correlate the glutamate concentration with injury severity. The results demonstrate that focal injuries of the spinal cord do not affect the glutamate concentration in CSF taken from the cerebellomedullary cistern. However, dogs with severe, acute thoracolumbar disc herniations have two- to 10-fold increases in glutamate concentration in their lumbar CSF at intervals of >12 h after injury. Moreover, the severity of their clinical signs is directly related to the glutamate concentration. Dogs with chronic compressive thoracolumbar lesions have a two-fold elevation of CSF glutamate concentration, suggesting that excitotoxicity may also be a component of chronic spinal cord compression.
- Published
- 1999
- Full Text
- View/download PDF
28. Prognostic factors for dogs with granulomatous meningoencephalomyelitis: 42 cases (1982-1996).
- Author
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Muñana KR and Luttgen PJ
- Subjects
- Animals, Breeding, Dogs, Encephalomyelitis mortality, Female, Granuloma mortality, Male, Meningoencephalitis mortality, Prognosis, Proportional Hazards Models, Retrospective Studies, Survival Analysis, Time Factors, Dog Diseases mortality, Encephalomyelitis veterinary, Granuloma veterinary, Meningoencephalitis veterinary
- Abstract
Objective: To assess signalment, clinical signs, results of CSF analysis, treatment, and survival times in dogs with granulomatous meningoencephalomyelitis (GME) and to identify factors associated with survival., Design: Retrospective study., Sample Population: Medical records of 42 dogs with GME., Procedure: Information on signalment, neurolocalization, presence of focal or multifocal signs, results of CSF analysis, method of treatment, and time from onset of clinical signs to death was retrieved from medical records of each dog. Kaplan-Meier survival analysis was used to assess survival times. The Cox proportional hazards method was used to identify predictors of survival., Results: Females and toy and terrier breeds were predisposed to GME. Half of the dogs had focal neurologic signs, and half had multifocal involvement. Clinical signs referable to the forebrain were most common with focal involvement, whereas signs referable to the forebrain and brainstem were most commonly seen with multifocal involvement. Cerebrospinal fluid analysis commonly revealed a mononuclear pleocytosis. Survival times ranged from 1 to > 1,215 days. Significant differences in survival times were demonstrated for the following factors: focal versus multifocal clinical signs, neurolocalization of focal signs, and treatment with radiation. Radiation was the only independent predictor of survival., Clinical Implications: Dogs with signs suggesting focal involvement of GME tend to survive longer than those with multifocal involvement. Radiation is an effective treatment for dogs with GME, particularly those with clinical signs suggesting focal involvement.
- Published
- 1998
29. Factor X deficiency in a cat.
- Author
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Gookin JL, Brooks MB, Catalfamo JL, Bunch SE, and Muñana KR
- Subjects
- Animals, Blood Coagulation drug effects, Blood Coagulation physiology, Cat Diseases blood, Cat Diseases drug therapy, Cats, Factor X analysis, Factor X Deficiency blood, Factor X Deficiency diagnosis, Male, Partial Thromboplastin Time, Prothrombin Time, Vitamin K analysis, Vitamin K pharmacology, Vitamin K therapeutic use, Cat Diseases diagnosis, Factor X Deficiency veterinary
- Abstract
Severe congenital deficiency of factor X was diagnosed in a 3-year-old castrated male domestic shorthair cat with clinical signs of generalized seizures and prolonged bleeding after venipuncture. Heritability of factor X deficiency was suspected because of a prolonged Russell's viper venom time in the dam and reductions in factor X activity in the dam and 1 sibling. To our knowledge, factor X deficiency in cats has not been reported previously. Definitive diagnosis for animals with clinical signs of coagulopathy may require repetition of coagulation screening tests using different assay methods or specific coagulation factor analyses.
- Published
- 1997
30. Encephalitis and meningitis.
- Author
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Muñana KR
- Subjects
- Animals, Bacterial Infections complications, Bacterial Infections veterinary, Brain diagnostic imaging, Brain pathology, Cat Diseases physiopathology, Cats, Dog Diseases physiopathology, Dogs, Encephalitis etiology, Encephalitis physiopathology, Meningitis etiology, Meningitis physiopathology, Mycoses complications, Mycoses veterinary, Protozoan Infections complications, Protozoan Infections, Animal, Tomography, X-Ray Computed methods, Tomography, X-Ray Computed veterinary, Virus Diseases complications, Virus Diseases veterinary, Cat Diseases etiology, Dog Diseases etiology, Encephalitis veterinary, Meningitis veterinary
- Abstract
Inflammation of the brain and meninges is a common cause of neurologic dysfunction in dogs and cats. A wide range of infectious agents has been demonstrated to cause encephalitis an meningitis, although there are many inflammatory conditions for which an etiology has not been found. Analysis of cerebrospinal fluid is the most useful diagnostic test to identify central nervous system inflammation. This article discusses the common causes of encephalitis and meningitis in dogs and cats, focusing on clinical presentation, diagnostic findings, treatment modalities, and prognosis.
- Published
- 1996
31. Long-term complications of diabetes mellitus, Part I: Retinopathy, nephropathy, neuropathy.
- Author
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Muñana KR
- Subjects
- Animals, Cats, Diabetes Complications, Diabetic Nephropathies etiology, Diabetic Neuropathies etiology, Diabetic Retinopathy etiology, Dogs, Time Factors, Cat Diseases etiology, Diabetes Mellitus veterinary, Diabetic Nephropathies veterinary, Diabetic Neuropathies veterinary, Diabetic Retinopathy veterinary, Dog Diseases etiology
- Abstract
Diabetic retinopathy, nephropathy, and neuropathy occur infrequently in small animals, but are capable of causing significant disease. The clinical and histopathologic findings seen with these late complications of diabetes are discussed. The pathogenesis of these disorders is most likely multifactorial; metabolic alterations secondary to the hyperglycemic state, and microvascular changes seen with diabetes have both been implicated. Current treatment consists of aggressive control of the hyperglycemia, as research continues into the pathology of the late complications in attempts to find a definitive therapy.
- Published
- 1995
- Full Text
- View/download PDF
32. Neurological manifestations of Niemann-Pick disease type C in cats.
- Author
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Muñana KR, Luttgen PJ, Thrall MA, Mitchell TW, and Wenger DA
- Subjects
- Animals, Cat Diseases genetics, Cats, Cerebellum pathology, Female, Liver pathology, Male, Neurologic Examination veterinary, Niemann-Pick Diseases pathology, Pedigree, Cat Diseases pathology, Niemann-Pick Diseases veterinary
- Abstract
Seven Domestic shorthair cats with a lysosomal storage disorder analogous to human Niemann-Pick disease type C, from a breeding colony were studied to characterize the neurological manifestations of this disorder. Affected cats were identified by means of liver biopsies at 4 to 6 weeks of age. Neurological examinations were performed at 2 week intervals from the onset of clinical signs. All cats displayed signs referrable to the cerebellum, with a subtle intention tremor noticed initially at 8 to 12 weeks of age; the disease was rapidly progressive. The tremor became more pronounced, menace response was lost, and severe dysmetria and ataxia developed. Three cats also had signs referrable to other areas of the central nervous system. Cats died or were euthanized between 12 and 43 weeks of age. Pathological findings included accumulation of substrate within neurons throughout the central nervous system, and axonal spheroid formation. The clinical and pathological findings in these cats are comparable to those in the human form of the disease.
- Published
- 1994
- Full Text
- View/download PDF
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