854 results on '"Mucocele pathology"'
Search Results
2. Delayed tension pneumocephalus and mucocele caused by nasal mucosa insertion into the cranial cavity: a report on histopathological considerations.
- Author
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Otani K, Omura K, Takaishi S, and Otori N
- Subjects
- Humans, Tomography, X-Ray Computed, Male, Female, Mucocele diagnostic imaging, Mucocele pathology, Pneumocephalus etiology, Pneumocephalus diagnostic imaging, Nasal Mucosa pathology
- Abstract
Competing Interests: Competing interests: None declared.
- Published
- 2024
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3. Examination of the thickness of the different components of gallbladder wall in cases with mucocele and/or cholecystitis.
- Author
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Azuma K, Mason G, and Monnet E
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- Animals, Dogs, Retrospective Studies, Male, Female, Cholecystectomy veterinary, Gallbladder Diseases veterinary, Gallbladder Diseases pathology, Gallbladder Diseases surgery, Mucocele veterinary, Mucocele pathology, Mucocele surgery, Gallbladder pathology, Gallbladder surgery, Cholecystitis veterinary, Cholecystitis pathology, Cholecystitis surgery, Dog Diseases pathology, Dog Diseases surgery
- Abstract
Objective: To assess the thickness of each layer of the gallbladder wall with different diseases in dogs., Sample: 72 gallbladders., Methods: Retrospective study of dogs that underwent cholecystectomy. Histopathological specimens of the gallbladders were reviewed. Histopathological diagnosis was made as gallbladder mucocele or cholecystitis, and cholecystitis was further categorized into chronic cholecystitis, acute-on-chronic cholecystitis, acute cholecystitis, and necrotic cholecystitis. The thickness of each layer of the gallbladder wall was measured., Results: 22 dogs were diagnosed with gallbladder mucocele without cholecystitis, 24 with gallbladder mucocele and cholecystitis, 20 with only cholecystitis, and 6 as normal. Histopathological subclassification of cholecystitis in 44 gallbladders led to diagnosis of chronic cholecystitis in 21 gallbladders, acute-on-chronic cholecystitis in 10 gallbladders, acute cholecystitis in 6 gallbladders, and necrotic cholecystitis in 7 gallbladders. The thickness of the entire wall of the gallbladder (P < .0001) and the thickness of the mucosa (P < .0001) and subserosa (P < .0001) were affected by the different disease processes., Clinical Relevance: Layers of the gallbladder wall were affected by diseases present in the gallbladder. It resulted in a difference in the thickness of the wall of the gallbladder among the gallbladder diseases in this study. Histopathological changes should be taken into consideration before surgery while deciding what technique to use to perform a cholecystectomy.
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- 2024
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4. Morphometric analysis of papillary synovial metaplasia-like changes in oral mucoceles.
- Author
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Pandiar D, Sutharshan GS, and Krishnan RP
- Subjects
- Humans, Male, Adult, Young Adult, Female, Retrospective Studies, Adolescent, Middle Aged, Child, Mouth Diseases pathology, Lip Diseases pathology, Metaplasia pathology, Mucocele pathology
- Abstract
Background: Oral mucoceles (OMs) are common cystic lesions seen mainly on the lower lip in young males. Histologically, OMs show variegated features such as clear cell changes, myxoglobulosis, calcifications, and papillary synovial metaplasia (PSM)-like changes. The aim of the present paper is to morphometrically analyze PSM-like changes seen in OMs., Methodology: Seventy-two cases of histologically proven OMs were retrospectively retrieved and divided into two groups: group I without PSM-like changes and group II with PSM-like changes. The internal area was measured using Image J software. SPSS version 26 was used to analyze the data., Results: There were 50 cases in group I (mean age 19.23 years) and 22 cases in group II (mean age 30.25 years). The lower lip was the most commonly affected site for both groups. The mean age in group II was significantly higher than group I. In contrast, the mean internal area was significantly higher in group I., Conclusion: We speculate that PSM-like changes in OMs represent an incomplete repair phenomenon. Knowledge of such an innocuous process is essential for differentiation from malignant histopathological mimickers., (© 2023 Wiley Periodicals LLC.)
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- 2024
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5. Increased lipogenesis and lipidosis of gallbladder epithelium in dogs with gallbladder mucocele formation.
- Author
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Gookin JL, Jewell DE, Aicher KM, Seiler GS, Cullen JM, and Mathews KG
- Subjects
- Animals, Dogs, Female, Case-Control Studies, Male, Lipidoses metabolism, Lipidoses pathology, Prospective Studies, Epithelium metabolism, Epithelium pathology, Lipid Metabolism, Mucocele metabolism, Mucocele pathology, Gallbladder metabolism, Gallbladder pathology, Lipogenesis, Dog Diseases metabolism, Dog Diseases pathology, Gallbladder Diseases metabolism, Gallbladder Diseases pathology, Gallbladder Diseases veterinary
- Abstract
Background: Gallbladder disease in people is frequently associated with disorders of lipid metabolism and metabolic syndrome. A recently emergent gallbladder disease of dogs, referred to as mucocele formation, is characterized by secretion of abnormal mucus by the gallbladder epithelium and is similarly associated with hyperlipidemia, endocrinopathy, and metabolic dysfunction. The cause of gallbladder mucocele formation in dogs is unknown., Methods: A prospective case-controlled study was conducted to gain insight into disease pathogenesis by characterization of plasma lipid abnormalities in 18 dogs with gallbladder mucocele formation and 18 age and breed matched control dogs using direct infusion mass spectrometry for complex plasma lipid analysis. This analysis was complemented by histochemical and ultrastructural examination of gallbladder mucosa from dogs with gallbladder mucocele formation and control dogs for evidence of altered lipid homeostasis of the gallbladder epithelium., Results: Gallbladder mucocele formation in dogs carried a unique lipidomic signature of increased lipogenesis impacting 50% of lipid classes, 36% of esterified fatty acid species, and 11% of complex lipid species. Broad enrichment of complex lipids with palmitoleic acid (16:1) and decreased abundance within complex lipids of presumptive omega-3 fatty acids eicosapentaenoic (20:5) and docosahexaenoic (22:6) was significant. Severe lipidosis of gallbladder epithelium pinpoints the gallbladder as involved causally or consequently in abnormal lipid metabolism., Conclusion: Our study supports a primary increase in lipogenesis in dogs with mucocele formation and abnormal gallbladder lipid metabolism in disease pathogenesis., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Gookin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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6. What factors influence mucocele recurrence?
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Himelfarb M, Britt MC, Flanagan S, and Green MA
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- Humans, Female, Male, Adolescent, Retrospective Studies, Child, Risk Factors, Adult, Child, Preschool, Age Factors, Boston epidemiology, Mucocele surgery, Mucocele pathology, Mucocele epidemiology, Recurrence
- Abstract
Objective: The purpose of this study was to identify whether age is associated with mucocele recurrence after excision., Study Design: This retrospective cohort study consisted of 492 patients who underwent oral mucocele excision at Boston Children's Hospital from 2010 to 2022. Fisher's exact tests were used to assess the association between age and mucocele recurrence. An adjusted logistic regression model was run to evaluate the effect of age on mucocele recurrence while controlling for confounders. A P value < .05 was considered significant., Results: Mucocele recurrence was observed in 24 cases (4.9%). There was a significant association between age and mucocele recurrence (2.2% for <7 years vs. 2.9% for 7 to <13 years vs. 9.2% for 13 to <18 years vs. 8.9% for >18 years; P = .005). Sex; history of behavioral disorders; mucocele size, duration, and location; suture technique; and type of anesthesia were not significantly associated with recurrence (P > .135). An adjusted logistic regression model verified a significant association between age and mucocele recurrence (odds ratio, 1.053; 95% confidence interval, 1.019-1.088; P = .035)., Conclusions: Mucocele recurrence occurs infrequently in patients younger than 7 years and is most prevalent in the teenage to young adult patient population. For every year increase in age, the odds of mucocele recurrence increase by 5.3%., Competing Interests: Declaration of interest None., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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7. Orofacial Cysts: A Single Institution Experience of 85 Cases in Enugu, Nigeria.
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Nwoga MC
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- Humans, Male, Female, Nigeria epidemiology, Retrospective Studies, Adult, Prevalence, Adolescent, Child, Middle Aged, Young Adult, Child, Preschool, Aged, Cysts epidemiology, Cysts pathology, Sex Distribution, Mucocele epidemiology, Mucocele pathology, Odontogenic Cysts epidemiology, Odontogenic Cysts pathology
- Abstract
Background: Orofacial cysts are pathologic cavities that could be symptomatic and may cause facial disfigurement. The only epidemiologic report of such lesions in Southeast Nigeria studied jaw cysts from 1987 to 1996. New studies reflecting recent research findings and classifications on the subject in Southeast Nigeria are lacking., Aim: To determine the prevalence and distribution of orofacial cysts in a tertiary hospital in Enugu, Southeast Nigeria., Methods: A 10-year retrospective study of patients with orofacial cysts diagnosed by histology was carried out., Results: Orofacial cysts constitute 9.5% (85) of 897 orofacial lesions identified. The male-to-female gender ratio was 1.2:1. The mean age (± standard deviation) at the onset of the cystic lesion was 28.58 (±16.98) years. Developmental odontogenic cysts 52.9% (45) and salivary cysts 18.8% (16) were the most common group of orofacial cysts. The most prevalent orofacial cysts were odontogenic keratocysts at 25.9% (22), mucoceles 16.5% (14), and dentigerous cysts 14.1% (12). Straw-colored aspirates 34.8% (16) and dark brown aspirates 28.3% (13) were the predominant cystic contents. The mandible 45.9% (39) and maxilla 27.1% (23) were the commonest sites for orofacial cysts, while the lip 9.4% (8) was the most frequent soft tissue site. A significant association exists between anatomical site and cyst type at a 95% confidence interval with P = 0.000, X2 = 247.17. Unilocular radiolucency 62.5% (20) and multilocular radiolucency 34.4% (11) were the most common radiographic features., Conclusion: Developmental odontogenic cysts particularly odontogenic keratocysts were most prevalent while mucocele was the most common soft tissue cyst., (Copyright © 2024 Copyright: © 2024 Nigerian Journal of Clinical Practice.)
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- 2024
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8. Retrospective study of oral lesions biopsied in babies and toddlers.
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Rezende KM, de Barros Gallo C, Nogueira GP, Corraza AC, Haddad AE, Gallottini M, and Bönecker M
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- Humans, Infant, Female, Male, Child, Preschool, Retrospective Studies, Biopsy, Infant, Newborn, Mucocele pathology, Granuloma, Pyogenic pathology, Granuloma, Pyogenic epidemiology, Granuloma, Pyogenic diagnosis, Papilloma pathology, Mouth Neoplasms pathology, Mouth Neoplasms epidemiology, Mouth Neoplasms diagnosis, Fibroma pathology, Fibroma epidemiology, Mouth Diseases pathology, Hemangioma pathology
- Abstract
Epidemiological data on the distribution of oral and maxillofacial diseases present in early childhood are scarce in the literature. This study analyzed the frequency of lesions biopsied in this region in children aged 0 to 3 years and sent for histopathological analysis in a reference oral pathology laboratory . Histopathological diagnostic data, lesion location, sex, and age were collected. Of the total of 93,950 records, 250 cases (0.27%) belonged to the age group from 0 to 3 years old. The most frequently diagnosed oral alterations were: mucocele (34/250; 13.6%); papilloma (11/250; 4.4%), giant cell fibroma (6/250; 2.4%), pyogenic granuloma (5/250; 2%) and hemangioma (3/250; 1.2%). The lip was the most affected site, followed by the gingiva and the tongue. These results generate information on the lesions most frequently diagnosed in early childhood, which facilitates the process of diagnosis and, consequently, treatment., (© 2023 Wiley Periodicals LLC.)
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- 2024
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9. HPV related p16 INK4A and HSV in benign and potentially malignant oral mucosa pathologies.
- Author
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Duś-Ilnicka I, Hałoń A, Perra A, and Radwan-Oczko M
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- Female, Humans, Male, Middle Aged, Biomarkers, Tumor analysis, Cross-Sectional Studies, Cyclin-Dependent Kinase Inhibitor p16 analysis, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Human Papillomavirus Viruses, Mouth Mucosa pathology, Adult, Aged, Carcinoma, Squamous Cell pathology, Fibroma complications, Fibroma pathology, Mucocele complications, Mucocele pathology, Papillomavirus Infections complications
- Abstract
Background: The association of Human Papilloma Virus (HPV) and Human Syncytial Virus (HSV) infection with inflammatory and potentially malignant disorders of the oral cavity (OPMD) is unknown. The aim of this cross-sectional study was to stablish the expression of the p16
INK4A and HSV proteins, to test potential correlation between those parameters in biopsies from clinically diagnosed oral lesions., Methods: Immunochemical analysis of 211 formalin-fixed, paraffin-embedded (FFPE) blocks from 211 individuals was provided. The clinical diagnosis included in the research were Oral lichen planus (N = 30), Oral Leukoplakia (N = 13) Mucocele (N = 25), Erosion/ulceration/ inflammation of mucosa (N = 8), Overgrowth of mucosa (N = 135)., Results: Two hundred eleven analyzed FFPE samples resulted with the median age of 58.5 years (the average age 54.0 years and SD ± 17 years). The female/male ratio was 2.3 (69.7% vs 30.3% respectively). All the samples positive for HSV also expressed p16INK4A (p = 0.000), that's showed various levels of association with the diverse clinical diagnosis reaching the higher level in OM 49.1% (29 positive samples) and OLP 30.5% (18). p16INK4A was associated with OLP at 30.5% (18), and fibroma 30.5%. HSV expression was mostly present in fibroma at 47.6% (10 positive samples)., Conclusion: HSV and p16INK4A positivity in relation to diagnosis of the biopsies showed statistically most often p16INK4A in OLP and fibroma. The results of co-expression of p16INK4A and HSV in mucocele and fibroma in oral mucosa suggest a cooperation between the molecular alterations induced by these two viruses. Squamous papilloma samples positive for p16INK4A were also positive for HSV, suggesting that the putative pro-oncogenic action of HSV could be an early event., (© 2024. The Author(s).)- Published
- 2024
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10. Mucocoele of the appendix.
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Oyeh E, Nsaful J, Bediako-Bowan A, Gbadamosi H, Mensah YB, Adu-Aryee NA, and Nyarko V
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- Humans, Male, Middle Aged, Aged, Tomography, X-Ray Computed, Appendiceal Neoplasms surgery, Appendiceal Neoplasms pathology, Appendiceal Neoplasms diagnostic imaging, Adenocarcinoma, Mucinous surgery, Adenocarcinoma, Mucinous pathology, Adenocarcinoma, Mucinous diagnostic imaging, Appendicitis surgery, Appendicitis diagnostic imaging, Appendectomy, Magnetic Resonance Imaging, Cecal Diseases surgery, Cecal Diseases pathology, Pseudomyxoma Peritonei pathology, Pseudomyxoma Peritonei surgery, Mucocele surgery, Mucocele diagnostic imaging, Mucocele pathology, Appendix pathology, Appendix diagnostic imaging, Appendix surgery
- Abstract
Introduction: Mucocoele of the appendix occurs in 0.2-0.7% of people in the world without any well-defined clinical symptoms. It occurs when there is an accumulation of mucous in the lumen of the appendix., Case Presentation: We present three cases: a 48-year-old male admitted to the emergency room with a one-day history of right iliac fossa pain. Abdominal examination was suggestive of acute appendicitis. The initial abdominal computerised tomography scan was reported as being unremarkable. At surgery, a firm tumour of the appendix was found, and a limited right hemicolectomy was done. Histopathology confirmed a mucocoele of the appendix with borderline mucinous histology.The second case is a 63-year-old man who presented with a one-year history of abdominal distension and weight loss. Previous abdominal ultrasound was suggestive of liver cirrhosis with significant ascitic fluid. Abdominal magnetic resonance imaging found an appendix mucocoele with infiltration of the omentum and scalloping of the liver surface suggestive of pseudomyxoma peritonei. A percutaneous biopsy of the omental mass confirmed metastatic mucinous adenocarcinoma of the appendix.The third case is a 68-year-old man who, during an annual medical check-up, had an incidental finding of a cystic right iliac fossa mass on ultrasound, confirmed on abdominopelvic computerised tomography scan to be an appendix mucocele. He had laparoscopic appendicectomy. The histopathological diagnosis confirmed a mucinous cystadenoma of the appendix., Conclusion: Preoperative diagnosis of appendiceal mucocoele is difficult and commonly discovered intraoperatively. The prognosis is good for the histologically benign type, but it is poor when malignant or peritoneal lesions are present., Funding: None declared., Competing Interests: Conflict of interest: None declared, (Copyright © The Author(s).)
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- 2024
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11. Tongue Mucoceles: a retrospective clinic-pathological evaluation of 240 cases.
- Author
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Patini R, Giuliani M, Gioco G, Tranfa M, Caponio VCA, Fantasia J, and Lajolo C
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- Male, Humans, Female, Young Adult, Adult, Retrospective Studies, Paresthesia, Neoplasm Recurrence, Local, Tongue surgery, Tongue pathology, Recurrence, Salivary Gland Diseases diagnosis, Salivary Gland Diseases surgery, Mucocele diagnosis, Mucocele surgery, Mucocele pathology
- Abstract
Background: Minor salivary glands can be found in the ventral and anterior part of the tongue; these glands can rarely develop mucoceles that, due to their rarity and their unusual clinical appearance, may present an interesting differential diagnosis. Mucoceles appear as an exophytic, sometimes pedunculated, lesion, which is a feature that is due to the absence of a capsule; thus, the glands are right beneath the mucosa and over the muscle tissue. The aim of this article is to retrospectively present and discuss the anatomy, pathology, clinical features and therapy of several cases of Blandin-Nunh mucoceles collected from two different institutions., Methods: A retrospective case review was carried out in two university institutions, retrieving all cases of tongue mucoceles from 1999 to today. Two oral pathologists reviewed all the slides, confirming the diagnosis. Demographic data of the patient, anatomic location and clinical appearance were retrieved from clinical charts, together with the type of surgical procedure and possible relapses., Results: A total of 240 cases of tongue mucoceles were gathered from the archives: the mean age was 22 years (DS = 14,7; Range 2-83), 126 were females (52,5%, mean age 22,7 years, DS = 16,5; Range 2-83), and 114 were males (47,5%, mean age 20,9 years, DS = 12,4; Range 3-73); in all cases, a history of trauma was reported. The ventral surface was the most frequent location (224 cases - 93,3%), and in the great majority (235 cases - 97,9%), pathology revealed mucous spillage with a wall formed by fibrous connective and granulation tissue with no epithelium lining the cavity. Superficial mucocele and sclerosing sialoadenitis were the more frequent pathological variants (21 cases - 8,8%). All lesions were treated with excision and enucleation of the servicing gland. The healing was uneventful in all cases, but there were four recurrences and two cases of sensory paraesthesia of the border of the tongue, all in males, except one case of paraesthesia in a female., Conclusions: Tongue mucoceles must be differentiated from many benign and malignant lesions. For this reason, surgical removal of the lesion and of the associated gland with a pathological exam is mandatory. In fact, the anatomical location of the glands and the possible pathological variants must be considered to reach a correct diagnosis and diminish possible relapses., Trial Registration: CE-Muc_Ton_3/2023., (© 2023. The Author(s).)
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- 2023
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12. Superficial mucoceles in cancer patients: a retrospective series from a Stomatology unit.
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Heguedusch D, Tomo S, Almeida OP, and Alves FA
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- Male, Humans, Female, Adult, Middle Aged, Aged, Retrospective Studies, Brazil epidemiology, Mucocele etiology, Mucocele pathology, Oral Medicine, Sjogren's Syndrome complications, Graft vs Host Disease complications
- Abstract
Background: The aim of this study is to relate all the superficial mucoceles found in a cancer center, described the association with oncological conditions, and discuss its etiology and pathology that we found in the past few years., Material and Methods: Sixteen cases of superficial mucocele were retrieved from the patients' records of the Stomatology Department of the A. C. Camargo Cancer Center, São Paulo, Brazil, and demographic and clinical data were collected from electronic medical records., Results: There were 16 patients, 8 patients were men and 8 women, with ages varying from 26 to 70 years old. Superficial mucoceles were observed in patients submitted to head and neck radiotherapy (n=6), graft versus host disease (n=4), one associated with oral mucositis related to allogenic bone marrow stem cells transplantation (n=1), systemic lupus (n=1), Sjögren's syndrome (n=1), oral lichenoid lesion associated with pembrolizumab (n=1) and no local or systemic inflammatory associated found (n=2)., Conclusions: This study reports a series of superficial mucoceles from a single stomatology unit. Most patients had superficial mucoceles secondary to head and neck radiotherapy and graft versus host diseases. However, two patients (12.5%) had mucoceles related to systemic inflammatory conditions (Sjögren's Syndrome and Systemic Lupus).
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- 2023
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13. Intravascular Papillary Endothelial Hyperplasia of Buccal Mucosa Masquerading as Mucocele - A Case Report.
- Author
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Pandiar D, Krishnan RP, Behera A, and Ramani P
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- Humans, Male, Diagnosis, Differential, Adult, Mouth Diseases diagnosis, Mouth Diseases pathology, Endothelium, Vascular pathology, Mucocele diagnosis, Mucocele pathology, Mouth Mucosa pathology, Hyperplasia
- Abstract
Introduction: Oral intravascular papillary endothelial hyperplasia (IPEH) is a rare entity with only 105 cases reported so far. Labial and buccal mucosa are the commonly affected sites. These sites are coincidently subjected to continuous minor trauma, which led the researchers to opine that IPEH could have a traumatic etiology with a further role of fibroblast growth factors., Clinical Presentation: We report a case of IPEH of right buccal mucosa in a 35 years old South Indian male who clinically presented as mucocele. Histopathologically, multiple lesions were found. Immunohistochemical and histochemical findings have also been presented., Discussion: The case is supported by a plausible mechanism involved in the pathogenesis. Thus, IPEH must be included in the clinical differential diagnosis of oral mucoceles and hemangioma., Takeaway Lessons: Being a reactive lesion, it does not require extensive treatment. Clinicians and histopathologists must be aware of this uncommon yet benign condition for appropriate therapy., (Copyright © 2024 Copyright: © 2024 Indian Journal of Dental Research.)
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- 2023
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14. Spectrum of Mucin-containing Lesions of the Breast: Multimodality Imaging Review with Pathologic Correlation.
- Author
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Thai JN, Lerwill MF, and Chou SS
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- Female, Humans, Breast diagnostic imaging, Breast pathology, Mucins, Adenocarcinoma, Mucinous diagnostic imaging, Adenocarcinoma, Mucinous pathology, Breast Neoplasms pathology, Mucocele pathology
- Abstract
Mucin-containing lesions of the breast encompass a wide range of benign and malignant processes. The spectrum of histologic findings includes incidental mucus-filled benign cysts or ducts, mucocele-like lesions (MLLs), mucin-producing ductal carcinoma in situ, and invasive mucinous carcinoma. MLL is characterized by the presence of mucin-containing cysts that are typically associated with extravasated stromal mucin. MLL is often benign but can be associated with epithelial atypia or malignancy. Mucinous carcinoma represents the malignant end of the spectrum of mucinous lesions of the breast. Evidence-based literature supports a conservative approach for benign MLLs without associated atypia or malignancy, reserving excision for those lesions exhibiting such pathologic features. The most common imaging finding for MLL is microcalcifications at mammography. No specific imaging feature is predictive of malignant outcome at surgical excision. Invasive mucinous carcinoma is a heterogeneous breast tumor subtype, as defined according to the World Health Organization criteria. Mucinous carcinomas are categorized into pure (>90% mucinous component) or mixed (10%-90% mucinous component) subtypes. Pure mucinous carcinomas are generally associated with excellent prognosis and survival, with a few exceptions. Mixed mucinous carcinomas do not have the same favorable prognosis and instead behave similarly to invasive breast carcinomas of no special type. Characteristic diagnostic imaging features can be identified for mucinous carcinoma based on its mucinous and nonmucinous contents.
© RSNA, 2023 Online supplemental material is available for this article. Quiz questions for this article are available through the Online Learning Center.- Published
- 2023
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15. Sphenoid sinus anatomical variants and pathologies: pictorial essay.
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Sethi KS, Choudhary S, Ganesan PK, Sood N, Ramalingum WBS, Basil R, and Dhawan S
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- Humans, Sphenoid Sinus diagnostic imaging, Sphenoid Sinus pathology, Multidetector Computed Tomography, Magnetic Resonance Imaging, Paranasal Sinus Diseases diagnostic imaging, Paranasal Sinus Diseases pathology, Sphenoid Sinusitis diagnosis, Sphenoid Sinusitis pathology, Mucocele diagnostic imaging, Mucocele pathology
- Abstract
The sphenoid sinus (SS) is one of the four paired paranasal sinuses (PNSs) within the sphenoid bone body. Isolated pathologies of sphenoid sinus are uncommon. The patient may have various presentations like headache, nasal discharge, post nasal drip, or non-specific symptoms. Although rare, potential complications of sphenoidal sinusitis can range from mucocele to skull base or cavernous sinus involvement, or cranial neuropathy. Primary tumors are rare and adjoining tumors secondarily invading the sphenoid sinus is seen. Multidetector computed tomography (CT) scan and magnetic resonance imaging (MRI) are the primary imaging modalities used to diagnose various forms of sphenoid sinus lesions and complications. We have compiled anatomic variants and various pathologies affecting sphenoid sinus lesions in this article., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2023
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16. Utility of flexible interventional endoscopy in endoscopic sinus surgery: a case series.
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Litzistorf Y, Gorostidi F, Lambercy K, and Reinhard A
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- Humans, Endoscopy methods, Prospective Studies, Retrospective Studies, Frontal Sinus diagnostic imaging, Frontal Sinus surgery, Frontal Sinus pathology, Mucocele pathology, Mucocele surgery, Papilloma, Inverted diagnostic imaging, Papilloma, Inverted surgery, Papilloma, Inverted pathology
- Abstract
Purpose: During endoscopic sinus surgery (ESS), difficult-to-reach pathologies need an extended endoscopic approach or an external approach. We started to use a flexible interventional endoscope (FIE) to evaluate the necessity of those approaches. The study's objective is to describe our experience and define patients who could benefit from this technique., Methods: We reviewed every patient who benefited from FIE associated with ESS at our tertiary University Hospital between January 2021 and February 2022., Results: During this period, we did 107 ESS, and 14 patients benefited from the FIE, representing 13% of our ESS. The median duration of the flexible endoscopy time was 14 min (4-38 min). We identified three groups of patients who can benefit from the FIE. The first one is for patients with a fungal infection, to control and to clean lateral recesses in a noninvasive manner. The second one is for patients with a pathology of the lateral frontal sinus, to remove the frontoethmoidal cells or mucocele with the biopsy forceps through the working channel. The third group is for patients with inverted papillomas, to precisely identify the insertion and to decide on the most appropriate surgical approach., Conclusions: In selected cases, using flexible endoscopy during ESS helps decide the optimal surgical approach and sometimes treat the pathology through a limited approach. Prospective studies for each group of patients are needed to confirm the benefit of this new combined procedure., (© 2022. The Author(s).)
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- 2023
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17. The Cancer Diaspora: A Rare Case of Pseudomyxoma Peritonei of Appendiceal Origin.
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Bathobakae L, Ozgur SS, Jariwala M, Kesrani J, Ajas S, Kumar M, and Akmal A
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- Female, Humans, Middle Aged, Mucocele complications, Mucocele pathology, Peritoneal Neoplasms diagnosis, Peritoneal Neoplasms therapy, Pseudomyxoma Peritonei diagnosis, Pseudomyxoma Peritonei drug therapy, Pseudomyxoma Peritonei etiology, Pseudomyxoma Peritonei pathology, Appendiceal Neoplasms complications, Appendiceal Neoplasms pathology
- Abstract
Pseudomyxoma peritonei (PMP) is a rare clinical entity characterized by widespread mucinous implants in the peritoneal cavity. Commonly seen in females in their 50s, PMP typically originates from ruptured appendiceal mucoceles that find refuge in the peritoneal space. Rarely, PMP may originate from the ovary, stomach, colon, or pancreas. Pseudomyxoma peritonei of colorectal origin is more malignant and has a lower survival rate. We report a case of a 59-year-old Hispanic woman with PMP who presented to the emergency room with a 3-month history of progressive abdominal distention. Pseudomyxoma peritonei was confirmed by computed tomography (CT) scan of the abdomen and pelvis and histopathology, and the patient underwent partial cytoreductive surgery. Given her Eastern Cooperative Oncology Group (ECOG) performance status of 1 despite extensive carcinomatosis, our patient may benefit from hyperthermic intraperitoneal chemotherapy (HIPEC) in the future., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2023
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18. Clinico-radiologic characteristics of lacrimal sac area swellings misdiagnosed as dacryocystocele or mucocele.
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Diab MM, Ali MJ, and Mohammed KK
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- Humans, Female, Retrospective Studies, Tomography, X-Ray Computed, Chronic Disease, Mucocele diagnostic imaging, Mucocele pathology, Nasolacrimal Duct diagnostic imaging, Lacrimal Duct Obstruction diagnosis, Lacrimal Apparatus Diseases diagnosis, Lacrimal Apparatus Diseases pathology, Orbital Diseases diagnosis, Eye Abnormalities pathology
- Abstract
Purpose: Several non-lacrimal lesions can present with lacrimal sac area swelling mimicking a dacryocystocele or mucocele with a possibility of misdiagnosis. This study investigates the clinic-radiologic characteristics of the mimicking conditions compared to true lacrimal sac distension., Design: Retrospective, comparative, interventional case series., Participants: Patients referred by primary care ophthalmologists between January 2015 and October 2021 with a misdiagnosis of dacryocystocele or lacrimal sac mucocele (n = 39) and an age-matched group of proven true lacrimal sac swelling (TLS group, n = 44)., Methods: Data collected included demographics, presenting features, investigations, management, histopathology, and outcomes. Both groups were statistically compared for several clinical and radiological variables., Results: Final diagnoses in the mimicking group were skin/subcutaneous swellings (14/39, 35.9%), vascular malformations (10/39, 25.6%), inferomedial anterior orbital cysts (7/39, 17.9%), sino-orbital masses (5/39, 12.8%). Female gender (<0.001), epiphora (p = 0.001), and discharge (p < 0.001) were significantly more frequent in the TLS group. The mimicking group was more likely to be associated with a longer swelling duration (p < 0.001), a swelling extending beyond the lacrimal sac area (p <0.001), orbital signs (p <0.001), and periorbital abnormality. Non-patent lacrimal irrigation (p < 0.001) was significantly more frequent in the TLS group. On imaging, all swellings in the mimicking group were separate from the lacrimal pathway and 94.9% (37/39) extended beyond the lacrimal sac fossa., Conclusion: Various cutaneous, subcutaneous, vascular, inferomedial orbital cystic, and sinonasal pathologies can present with lacrimal sac area swelling and mimic a TLS. A high index of suspicion, a thorough clinical evaluation and proper imaging are essential to avoid a misdiagnosis.
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- 2023
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19. Oral mucoceles: A Brazillian Multicenter Study of 1,901 Cases.
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Miranda GGB, Chaves-Junior SC, Lopes MP, Rocha TBD, Colares DF, Ito FA, Cavalcante IL, Cavalcante RB, Andrade BAB, Nonaka CFW, Alves PM, Albuquerque-Júnior RLC, and Cunha JLS
- Subjects
- Humans, Male, Female, Child, Preschool, Child, Adolescent, Young Adult, Adult, Retrospective Studies, Cross-Sectional Studies, Mucocele epidemiology, Mucocele pathology, Salivary Gland Diseases pathology, Salivary Gland Diseases surgery, Mouth Diseases epidemiology, Mouth Diseases pathology
- Abstract
Oral mucocele (OM) is the most common lesion of minor salivary glands. The present study aimed to report the clinical and demographic features of a large series of OMs and identify possible predictive variables associated with the recurrence rate of these lesions. A retrospective descriptive cross-sectional study was performed. A total of 43,754 biopsy records from four pathology services in Brazil were analyzed. All cases of OMs were reviewed, and clinical and demographic data were collected. The study comprised 1,002 females (56.2%) and 782 males (43.8%), with a mean age of 19.8±16.4 years (range: 01-87 years) and a 1.3:1 female-to-male ratio. The lower lip (n=1,160; 67.4%), and floor of the mouth (n=172; 10.0%), were the most common affected sites, presenting clinically as nodules (n=978; 79.4%) of smooth surface (n=428; 77.5%) and normal color (n=768, 46.7%). Excisional biopsy was the treatment in most cases (n=1,392; 78.0%). Recurrent OMs represented 6.2% of all diagnosed cases (n=117). OMs recurred more commonly in younger patients (aged<20 years) (p<0.0001), in lesions larger than 2 cm in diameter (p<0.0001), and in those located in the ventral tongue (p=0.0351). Also, recurrence rates were higher significantly in cases treated with laser surgery than in those with conventional surgery (p=0.0005). Patients with OMs should be carefully informed of its possible recurrence, especially when found on the ventral tongue of young patients.
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- 2022
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20. Multidrug resistant Enterococcus faecium isolate from cholangitis/cholecystitis in a dog.
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Sposato A, Cordisco M, de Ruvo G, Ferro S, Raineri RA, Trotta A, Buonavoglia D, and Corrente M
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- Animals, Dogs, Cholangitis veterinary, Cholecystitis veterinary, Dog Diseases pathology, Enterococcus faecium, Mucocele pathology, Mucocele surgery, Mucocele veterinary
- Abstract
Mucocele and cholecystitis were diagnosed in a 10 year-old Shetland-sheepdog presenting aspecific clinical signs. Blood examinations and ultrasonography investigation were performed before to surgical approach, which allowed to collect biopsies and samples for bacteriological analyses. In addition, the patient was subjected to cholecystectomy. A multidrug resistant Enterococcus faecium was isolated from the gallbladder specimens. On the basis of antimicrobial susceptibility test, nitrofurantoin was used. The correct bacteriological diagnosis is necessary to set up effective therapy, influencing the patient's prognosis and improving the recovery time., (© 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.)
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- 2022
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21. Selection of mucocele management technique: considerations in pediatric patients.
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Alfaqih SA, Bacon JP, and Childers ELB
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- Child, Humans, Male, Cryosurgery, Mucocele pathology, Mucocele surgery
- Abstract
The objectives of this article are to describe the surgical excision of an oral mucocele in a 9-year-old boy and to examine the literature on mucocele management approaches, highlighting their advantages and disadvantages in terms of a patient's ability to cooperate in the dental chair. In the present case, a 9-year-old boy who was known to be a cooperative patient underwent conventional surgical excision and tolerated the procedure well. A review of the literature from 2010 to 2018 revealed 20 relevant studies outlining a variety of approaches to mucocele management, including surgical excision, intralesional corticosteroid injection, laser removal, micromarsupialization, cryosurgery, and withholding treatment for cases in which a lesion is small and allowed to spontaneously regress. While conventional surgical excision of mucoceles is suitable for cooperative patients, alternative approaches may offer reduced chair time, minimal intraoperative bleeding, and enhanced postoperative recovery. For pediatric patients who demonstrate maladaptive behavior, certain treatment modalities may prove superior to surgical excision for the management of mucoceles.
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- 2022
22. Clinical relationship between histopathological necrotic/partial necrotic findings and disease condition of gallbladder mucoceles in dogs.
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Itoh H, Igari K, Tani K, Sunahara H, Nemoto Y, Nakaichi M, Iseri T, Horikirizono H, and Itamoto K
- Subjects
- Animals, Dogs, Humans, Necrosis complications, Necrosis veterinary, Retrospective Studies, Cholecystitis complications, Cholecystitis veterinary, Dog Diseases pathology, Gallbladder Diseases complications, Gallbladder Diseases surgery, Gallbladder Diseases veterinary, Mucocele complications, Mucocele pathology, Mucocele veterinary
- Abstract
Gallbladder mucocele (GM) is a common extrahepatic biliary disease recognized in dogs and is defined as the expansion and extension of the gallbladder by an accumulation of semi-solid bile or bile acid. Histopathological diagnosis of necrotizing cholecystitis and transmural coagulative necrosis of the gallbladder wall shows poor prognosis. Conversely, histopathological diagnosis with partial necrotic findings is often achieved. We hypothesized that histopathological partial necrosis of the gallbladder wall is the primary lesion of necrotic cholecystitis or transmural ischemic necrosis. Therefore, we investigated the relationship between histopathological necrosis/ partial necrosis findings and their clinical conditions. We retrospectively analyzed 55 dogs diagnosed with GM that had undergone cholecystectomy at the Yamaguchi University Animal Medical Center. The group with histopathological necrosis/partial necrosis of the gallbladder wall showed elevated levels of preoperative white blood cells, alanine transaminase, alkaline phosphatase, γ-glutamyltransferase, total bilirubin, and C-reactive protein compared to the non-necrotic group. Partial necrosis of the gallbladder wall may affect the progression of the disease and hematological abnormalities. Additionally, all death cases until 2 weeks were included in the histopathological necrosis/partial necrosis group. In this study, we found that poor prognosis factors were associated with partial necrosis of the gallbladder wall. Furthermore, these cases of partial necrosis showed elevated levels of blood test parameters. These results suggest that necrosis of the gallbladder wall is associated with poor prognosis and poor pathophysiological conditions., (Copyright© by the Polish Academy of Sciences.)
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- 2022
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23. Mucin Neovascularization as a Diagnostic Aid to Distinguish Mucinous Carcinomas From Mucocele-like Lesions in Breast Core Needle Biopsies.
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Onken AM, Collins LC, and Schnitt SJ
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- Biopsy, Large-Core Needle, Breast pathology, Female, Humans, Mucins, Neovascularization, Pathologic pathology, Adenocarcinoma, Mucinous diagnosis, Adenocarcinoma, Mucinous pathology, Breast Neoplasms diagnosis, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Mucocele diagnosis, Mucocele pathology
- Abstract
The distinction between mucinous carcinomas (MCs) and mucocele-like lesions (MLLs), particularly those containing detached epithelial fragments, can be problematic in the limited samples afforded by breast core needle biopsies (CNBs). Neovascularization of mucin has been proposed as a criterion to distinguish MC from MLL, but its value in helping to categorize mucin-producing breast lesions in CNB has not been previously investigated. To address this, we evaluated mucin neovascularization on hematoxylin and eosin (H&E)-stained sections of 140 CNB containing mucin-producing breast lesions including 52 MC, 17 mucin-producing ductal carcinoma in situ (mDCIS), and 71 MLL. In 116 cases with sufficient remaining material (42 MC, 16 mDCIS, and 58 MLL), we also assessed mucin neovascularization on CD31 immunostains. On H&E-stained sections, neovascularization of mucin, defined as delicate, thin-walled microvessels in mucin, and unassociated with fibrous septae, was identified significantly more frequently in MC than in MLL (69.2% vs. 14.1%; P=0.0001). The difference in the frequency of mucin neovascularization between MC and MLL was even greater on CD31 immunostains (97.6% vs. 13.8%, P<0.00001). The sensitivity, specificity, positive predictive value, and negative predictive value of mucin neovascularization for categorizing a lesion as MC were 69.2%, 85.8%, 78.3%, and 79.2%, respectively, for H&E-stained sections and 97.6%, 86.2%, 83.7%, and 98.0%, respectively, for CD31 immunostains. We conclude that mucin neovascularization is significantly more common in MC than in MLL in breast CNB on H&E-stained sections and particularly on CD31 immunostains and may be a valuable adjunct in distinguishing between MC and MLL in problematic cases., Competing Interests: Conflicts of Interest and Source of Funding: Dana-Farber/Harvard Cancer Center is supported in part by an NCI Cancer Center Support Grant # NIH 5 P30 CA06516. The authors received grant funding from the Department of Pathology at Beth Israel Deaconess Medical Center for the performance of CD31 immunostain. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2022
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24. Adult With Abdominal Pain.
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Nghiem T, Patel PB, Harfouch N, Greenstein J, and Hahn B
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- Abdominal Pain diagnostic imaging, Appendix pathology, Female, Humans, Middle Aged, Mucocele pathology, Tomography, X-Ray Computed, Ultrasonography, Appendix diagnostic imaging, Mucocele diagnostic imaging
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- 2022
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25. Mucocele-like Lesion of the Breast Diagnosed on Core Biopsy.
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Towne WS, Michaels AY, and Ginter PS
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- Biopsy, Large-Core Needle, Breast pathology, Calcinosis, Female, Humans, Retrospective Studies, Breast Diseases diagnosis, Breast Diseases pathology, Breast Neoplasms pathology, Carcinoma, Intraductal, Noninfiltrating pathology, Mucocele diagnosis, Mucocele pathology
- Abstract
Context.—: Mucocele-like lesion of the breast (MLL) is an uncommon entity, and recent studies show low rates of upgrade from core needle biopsy (CNB) to excision., Objective.—: To evaluate features associated with upgrade of MLLs diagnosed on CNB., Design.—: Seventy-eight MLLs diagnosed on CNB from 1998-2019 and subsequent excisions were reviewed. Histologic parameters evaluated included the presence of atypia, presence and morphology of calcifications, and morphologic variant (classic [C-MLL], duct ectasia-like [DEL-MLL], or cystic mastopathy-like [CML-MLL])., Results.—: Overall, 45 MLLs lacked atypia and 33 were associated with atypia (atypical ductal hyperplasia, 32; atypical lobular hyperplasia, 1). Most were C-MLLs (61) with fewer DEL-MLLs (14) and CML-MLLs (3). Half showed both coarse and fine calcifications, with fewer showing only coarse or fine calcifications, and some showing none. Subsequent excision or clinical follow-up was available for 25 MLLs without atypia-of which 2 (8.0%) were upgraded to ductal carcinoma in situ (DCIS)-and 23 with atypia, of which 4 (17.4%) were upgraded to DCIS. No cases were upgraded to invasive carcinoma. All upgraded cases showed coarse calcifications on CNB, and all upgraded cases were associated with residual calcifications on post-CNB imaging., Conclusions.—: Most MLLs present as calcifications and nearly half are associated with atypia. Upgrade to DCIS is twice as frequent in MLLs with atypia versus those without. A predominance of coarse calcifications and the presence of residual targeted calcifications following core biopsy may be associated with higher upgrade rates.
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- 2022
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26. Clinical outcome and quality of life of lacrimal sac mucocele treated via endoscopic posterior approach.
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Pirola F, Spriano G, Ferreli F, Russo E, Di Bari M, Giannitto C, De Virgilio A, Mercante G, Vinciguerra P, Di Maria A, and Malvezzi L
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Mucocele pathology, Quality of Life, Retrospective Studies, Surveys and Questionnaires, Treatment Outcome, Young Adult, Dacryocystorhinostomy methods, Endoscopy methods, Lacrimal Duct Obstruction pathology, Mucocele surgery, Nasolacrimal Duct surgery
- Abstract
Objective: Dacryocystorhinostomy (DCR) is the surgical treatment for lacrimal sac mucoceles (LSM), yet variants of the procedure are several. Since LSM causes bone remodeling and thinning, especially of the lacrimal bone, osteotomy at that site is reasonably the easiest. The aim of the study is to support treatment of LSM via a posterior DCR approach, in a large cohort of cases, and report patients' quality of life after the procedure with validated questionnaires., Methods: Single-center observational retrospective study on a specific methodology (endoscopic-DCR via posterior approach). Consecutive patients with LSM were enrolled in 2008-2020; CT scans were reviewed, bone thickness was measured bilaterally and compared. Resolution of mucocele, epiphora and infection were analyzed after 6-months. Patients were administered the Munk Score and Lacrimal Symptom Questionnaire (Lac-Q). Statistical analysis was done to compare bone thickness between the two sides; descriptive analysis of the questionnaires results was presented., Results: Forty-four patients with LSM were enrolled. The LSM side showed frontal process thickness of 4.00 ± 1.06 mm (vs 3.90 ± 1.03 on the unaffected side; p = 0.23) and a lacrimal bone of 0.32 ± 0.12 mm (vs 0.41 ± 0.12; p < 0.001). Resolution of infection was achieved in 97.4% cases, anatomical patency in 87.2%. After 5 years, 84.6% of patients reported no relevant epiphora (Munk score 0-1). Social impact (Lac-Q) due to lacrimal malfunctioning was still noted in 30.8% patients., Conclusions: Adult LSM is a rare condition and DCR remains the mainstay of treatment. LSM physiopathology may support a preferred surgical choice via a posterior approach. Despite objective patency, some lacrimal way malfunctioning may be experienced in a minority of cases., (Copyright © 2021 Elsevier Inc. All rights reserved.)
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- 2022
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27. Gastrointestinal: Mucocele appendix with atypical "volcano sign".
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Vashistha N, Deo A, and Singhal D
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- Humans, Appendix pathology, Mucocele pathology
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- 2022
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28. Mucocele-like lesions of the breast - A radiological and clinicopathological analysis.
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Griffiths R, Alarcon L, Bonello V, Scott V, and Szollosi Z
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- Adult, Aged, Aged, 80 and over, Female, Humans, London, Mammography, Middle Aged, Retrospective Studies, Breast Neoplasms diagnostic imaging, Breast Neoplasms pathology, Mucocele diagnostic imaging, Mucocele pathology
- Abstract
Introduction: Mucocele-like lesions (MLL) of the breast are rare entities which are considered to harbor uncertain malignant potential. Current UK guidelines recommend vacuum assisted excision (VAE) of all such lesions regardless of whether they display epithelial atypia. This study sought to review the key histological and radiological features of MLLs and compare their differing outcomes based on the presence of epithelial atypia., Methods: Pathology records of a single breast cancer screening center were retrospectively searched for all biopsy diagnosed MLLs over an 11-year period. Upgrade rates to malignancy (positive predictive values) were calculated by reviewing histology from the initial core biopsy and comparing with the corresponding excision specimen. Radiological images were simultaneously reviewed to provide radiological-pathological correlation., Results: Three of 11 patients (27.3%) with atypical MLLs on biopsy had malignant outcomes at excision, compared with only 1 of 36 patients (2.8%) with non-atypical MLLs. The majority of MLLs (93%) were identified as microcalcifications on mammographic imaging. No specific radiological features were predictive of malignancy., Conclusions: Our data suggest that MLLs without atypia are potentially overtreated with current protocols and could be managed conservatively with radiological follow up. Radiological-pathological correlation is essential., (Copyright © 2021. Published by Elsevier Inc.)
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- 2021
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29. Paranasal mucoceles in children with cystic fibrosis: Management of a not so rare clinical condition.
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Rampinelli V, Ferrari M, Poli P, Lancini D, Mattavelli D, Timpano S, Redaelli de Zinis LO, Badolato R, Padoan R, and Berlucchi M
- Subjects
- Adolescent, Age Factors, Child, Child, Preschool, Female, Humans, Infant, Male, Mucocele diagnosis, Mucocele etiology, Mucocele pathology, Paranasal Sinus Diseases diagnosis, Paranasal Sinus Diseases etiology, Paranasal Sinus Diseases pathology, Paranasal Sinuses diagnostic imaging, Paranasal Sinuses surgery, Rare Diseases, Retrospective Studies, Tomography, X-Ray Computed, Treatment Outcome, Cystic Fibrosis complications, Endoscopy methods, Mucocele surgery, Nasal Surgical Procedures methods, Paranasal Sinus Diseases surgery
- Abstract
Purpose: Paranasal mucocele (PM) is reported as a complication in children with cystic fibrosis (CF) in up to 4% of patients. The objective of this study was to identify PMs in the personal large series of children with CF and to assess their diagnosis and treatment., Material and Methods: Medical records of children with CF and PM who were admitted and treated by means of endoscopic nasal surgery between 2004 and 2020 were retrospectively reviewed., Results: Thirty-four patients were included in the study (mean age 7.7 years). CT scan of sinuses showed a total of 53 PMs. Nasal endoscopic findings suggestive for PM were present in almost 80% of patients. PMs were located in the maxillary, ethmoid, and sphenoid sinuses in 29/34 (85.3%, bilateral in 17 cases), 4/34 (11.8%) and 1/34 (2.9%) patients, respectively. Marsupialization of PMs was performed in all patients using an endoscopic transnasal approach. No complications were observed. Resolution of symptoms and normalization of the endoscopic nasal picture was evident in all patients. After a mean follow-up of 85 months, no recurrences were observed., Conclusions: To the best of our knowledge, this is the largest series of CF patients with PMs. Even if not frequently reported in the literature, PMs should not be considered an uncommon finding in patients affected by CF. Routine nasal endoscopy is mandatory to favor early diagnosis. Endoscopic transnasal marsupialization represents the gold standard of care for patients with CF and PM(s)., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2021
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30. A Rare Case of Fungal Rhinosinusitis Caused by Scedosporium apiopermum.
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Naik PP, Bhatt K, Richards EC, Bates T, Jahshan F, Chavda SV, and Ahmed SK
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- Adult, Female, Humans, Mucocele pathology, Rhinitis pathology, Scedosporium, Sinusitis pathology, Mucocele microbiology, Mycetoma pathology, Rhinitis microbiology, Sinusitis microbiology
- Abstract
Fungal rhinosinusitis (FRS) is inflammation of the paranasal sinus mucosa due to fungal infections, which can be invasive or non-invasive. The occurrence of a sphenoid mucocele with a fungal ball is rare. We report a case of sphenoid sinus mucocele with a fungal ball caused by Scedosporium apiopermum in a 32-year-old female who presented to the Emergency Department with persistent headache not relieved on medications. The radiological images showed a mucocele with clival osteomyelitis. Urgent endoscopic examination and debridement was undertaken which demonstrated a mucocele with fungal ball. Microbiological examination confirmed it to be Scedosporium apiopermum., (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2021
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31. The Investigation of 14 Appendiceal Mucocele Cases Encountered in 4850 Appendectomy Patients.
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Şentürk M, Yavuz Y, Alkan S, and Kafadar MT
- Subjects
- Adult, Appendectomy methods, Appendicitis diagnosis, Appendicitis pathology, Appendix diagnostic imaging, Appendix surgery, Diagnosis, Differential, Female, Humans, Incidence, Male, Middle Aged, Mucocele diagnosis, Mucocele pathology, Mucocele surgery, Pseudomyxoma Peritonei pathology, Pseudomyxoma Peritonei prevention & control, Retrospective Studies, Young Adult, Appendectomy statistics & numerical data, Appendicitis surgery, Appendix pathology, Laparoscopy statistics & numerical data, Mucocele epidemiology
- Abstract
Background: Appendiceal mucocele is a rarely seen disease which occurs when the appendix lumen is filled and obstructed by mucous. In our study, we aimed to reveal the surgical approach of our clinic, features of tumors, and clinical presentations in line with literature in cases of appendix mucocele., Methods: Fourteen appendix mucocele patients who were admitted in our hospital between 2012 and 2019 were examined retrospectively in the electronic recording medium. Our patients were evaluated in terms of age, gender, clinical status, operation, imaging results, and pathology results., Results: Of the fourteen patients, 12 applied to the emergency department and 2 to the general surgery clinic. All of our patients had abdominal pain at the time of admission. In the physical examination, 5 (35%) patients had defenses, 10 (71%) patients had rebound tenderness, and 12 (85%) patients had tenderness. In preoperative imaging studies, 11 patients were interpreted as having acute appendicitis and 3 patients were evaluated as having appendix mucocele. The pathological results were reported as 6 patients had appendiceal mucocele and 8 patients had appendiceal mucocele together with acute appendicitis., Conclusion: Appendiceal mucocele is a disease which generally causes similar clinical findings of acute appendicitis. Ultrasound and CT may be useful in preoperative diagnosis. Surgical treatment options of mucocele are open or laparoscopic appendectomy, cecum resection, and right hemicolectomy. Although its incidence is low, due to pseudomyxoma peritonei, it is a pathology that requires careful surgery.
- Published
- 2021
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32. High-Risk Lesions Detected by MRI-Guided Core Biopsy: Upgrade Rates at Surgical Excision and Implications for Management.
- Author
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Michaels AY, Ginter PS, Dodelzon K, Naunheim MR, and Abbey GN
- Subjects
- Adult, Aged, Aged, 80 and over, Breast diagnostic imaging, Breast Carcinoma In Situ diagnostic imaging, Breast Carcinoma In Situ pathology, Breast Neoplasms diagnostic imaging, Breast Neoplasms surgery, Carcinoma, Intraductal, Noninfiltrating diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating pathology, Cicatrix diagnostic imaging, Cicatrix pathology, Female, Humans, Image-Guided Biopsy statistics & numerical data, Middle Aged, Mucocele diagnostic imaging, Mucocele pathology, Papilloma, Intraductal diagnostic imaging, Papilloma, Intraductal pathology, Precancerous Conditions diagnostic imaging, Precancerous Conditions surgery, Retrospective Studies, Breast pathology, Breast Neoplasms pathology, Image-Guided Biopsy methods, Magnetic Resonance Imaging, Interventional statistics & numerical data, Precancerous Conditions pathology
- Abstract
OBJECTIVE. The purpose of our study was to evaluate the upgrade rates of high-risk lesions (HRLs) diagnosed by MRI-guided core biopsy and to assess which clinical and imaging characteristics are predictive of upgrade to malignancy. MATERIALS AND METHODS. A retrospective review was performed of all women who presented to an academic breast radiology center for MRI-guided biopsy between January 1, 2015, and November 30, 2018. Histopathologic results from each biopsy were extracted. HRLs-that is, atypical ductal hyperplasia (ADH), lobular carcinoma in situ (LCIS), atypical lobular hyperplasia (ALH), radial scar, papilloma, flat epithelial atypia (FEA), benign vascular lesion (BVL), and mucocelelike lesion-were included for analysis. Clinical history, imaging characteristics, surgical outcome, and follow-up data were recorded. Radiologic-pathologic correlation was performed. RESULTS. Of 810 MRI-guided biopsies, 189 cases (23.3%) met the inclusion criteria for HRLs. Of the 189 HRLs, 30 cases were excluded for the following reasons: 15 cases were lost to follow-up, six cases were in patients who received neoadjuvant chemotherapy after biopsy, two lesions that were not excised had less than 2 years of imaging follow-up, and seven lesions had radiologic-pathologic discordance at retrospective review. Of the 159 HRLs in our study cohort, 13 (8.2%) were upgraded to carcinoma. Surgical upgrade rates were high for ADH (22.5%, 9/40) and FEA (33.3%, 1/3); moderate for LCIS (6.3%, 3/48); and low for ALH (0.0%, 0/11), radial scar (0.0%, 0/28), papilloma (0.0%, 0/26), and BVL (0.0%, 0/3). Of the upgraded lesions, 69.2% (9/13) were upgraded to ductal carcinoma in situ (DCIS) or well-differentiated carcinoma. ADH lesions were significantly more likely to be upgraded than non-ADH lesions ( p = .005). CONCLUSION. ADH diagnosed by MRI-guided core biopsy warrants surgical excision. The other HRLs, however, may be candidates for imaging follow-up rather than excision, especially after meticulous radiologic-pathologic correlation.
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- 2021
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33. From Diagnosis to Management; Mucocele of Stump Appendicitis, Extremely Rare Finding in an Uncommon Surgical Disease: Literature Review.
- Author
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Ali SM, Al-Tarakji M, Shahid F, Qabani AS, Shah AA, Ahmed K, Khan MB, and Inamullah
- Subjects
- Appendectomy, Appendicitis surgery, Appendix pathology, Appendix surgery, Cecal Diseases diagnosis, Cecal Diseases pathology, Cecal Diseases surgery, Humans, Mucocele pathology, Postoperative Complications pathology, Mucocele diagnosis, Mucocele surgery, Postoperative Complications diagnosis, Postoperative Complications surgery
- Abstract
Mucocele of the appendix is the accumulation of mucoid material in the appendiceal lumen. Although the terminology is imprecise, as it does not differentiate between the benign and malignant nature of the condition, preoperative recognition is imperative as spillage of the mucus during surgical handling can result in grave complications like pseudomyxoma peritonei. Mucocele developing in a stump of the appendix, i.e., a remnant of appendiceal tissue after surgical removal of an inflamed organ, is an extremely uncommon phenomenon, as not many cases are reported in the literature. In this review, all cases reported in English literature are discussed., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Syed Muhammad Ali et al.)
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- 2021
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34. Appendicular myxoglobulosis; a rare form of appendicular mucocele.
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Joly MA, Aime A, Souraud JB, and Malgras B
- Subjects
- Appendectomy methods, Cecal Diseases pathology, Cecal Diseases surgery, Female, Humans, Laparoscopy, Mucocele pathology, Mucocele surgery, Tomography, X-Ray Computed, Young Adult, Appendix diagnostic imaging, Appendix pathology, Appendix surgery, Cecal Diseases diagnosis, Mucocele diagnosis
- Abstract
Myxoglobulosis is a particular, rare, form of appendicular mucocele, characterized by the presence of numerous, occasionally calcified, globules that are grouped together like grapes, and look like pearls or fish eggs, in the appendicular lumen. The diagnosis of myxoglobulosis is most often fortuitous, but sometimes, can be made in the face of acute appendicitis or another setting of abdominal pain. Imaging (sonography or computerized tomography (CT)) is highly suggestive when it shows a cystic, encapsulated, oblong, well-delineated mass, containing (heterogeneous, liquid, and viscous) mucus with calcified globules. In contrast to acute appendicitis, the wall of the appendix is thin (<6mm) and there is no peri-appendicular inflammation. Long-term complications are similar to other appendicular mucoceles, including invagination, bleeding, perforation, peritonitis and peritoneal pseudomyxoma., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
- Published
- 2020
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35. Hypoesthesia of midface by isolated Haller's cell mucocele.
- Author
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Choi JH
- Subjects
- Endoscopy, Ethmoid Sinus pathology, Humans, Hypesthesia pathology, Magnetic Resonance Imaging, Male, Maxillary Sinus diagnostic imaging, Middle Aged, Mucocele pathology, Peripheral Nervous System diagnostic imaging, Ethmoid Sinus surgery, Face diagnostic imaging, Hypesthesia diagnosis, Maxillary Sinus surgery, Mucocele surgery
- Published
- 2020
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36. Oral mucocele in infant with an unusual presentation.
- Author
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Suryavanshi R, Abdullah A, Singh N, and Astekar M
- Subjects
- Humans, Infant, Medical Illustration, Tongue pathology, Mucocele pathology, Tongue Diseases pathology
- Abstract
Mucocele is a benign lesion characterised by an extravasation or retention of mucous secretion in submucosal tissue from minor salivary glands. The occurrence of mucocele is common in the oral cavity, with more than 70% of cases on lower labial mucosa. The occurrence of mucocele on the tongue is considered rare and accounted for only 2.25% in the previous literature. Histopathological examination plays a great role in the confirmation of the clinical diagnosis. Management of mucocele is at times challenging. This paper highlights a rare case of mucocele in a 5-month-old infant who was successfully managed under day-care anaesthesia., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2020
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37. Optic neuropathy caused by expanded Onodi cell mucocele.
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Morino T, Yanagihara T, Kuroyanagi H, and Ohto H
- Subjects
- Aged, Endoscopy, Humans, Magnetic Resonance Imaging, Male, Mucocele surgery, Optic Nerve Diseases diagnostic imaging, Optic Nerve Diseases surgery, Tomography, X-Ray Computed, Mucocele pathology, Optic Nerve Diseases etiology
- Abstract
Competing Interests: Competing interests: None declared.
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- 2020
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38. Laryngeal Myxoglobulosis: A Rare Histologic Variant of Mucocele. The First Reported Case.
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Krajinović M, Fajdiga I, and Gale N
- Subjects
- Humans, Male, Middle Aged, Smoking pathology, Laryngeal Diseases pathology, Mucocele pathology, Vocal Cords pathology
- Abstract
Myxoglobulosis is a rare histologic variant of mucocele that is characterized by transformation of mucin into eosinophilic globules. The globules frequently demonstrate a lamellar pattern and are surrounded by an inflammatory cell infiltrate. Myxoglobulosis has not yet been described in laryngeal mucosa. A 62 year old man presented for a check-up with hoarseness of 2 months duration. He was a current smoker and reported a 40 year habit. An asymmetrical swelling along the length of both vocal cords was consistent with a clinical diagnosis of Reinke's edema. The histopathologic examination demonstrated bilateral pseudocyst formation within Reinke's space. Extravasated mucin was present in the form of eosinophilic globules that filled the left Reinke's space almost entirely and were also seen on the right side. The pseudocyst, mucinous globules, and accompanying inflammatory cells were characteristic of myxoglobulosis. The sequelae of nicotine abuse, including inflammation, increased mucous secretion, and a rasping cough, are considered to be the main etiological factors of laryngeal myxoglobulosis. The patient had no evidence of voice disorder at 18 month follow-up. This case report contributes to the recognition of an exceptionally rare histologic variant of laryngeal mucocele.
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- 2020
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39. [Recurrent superficial mucoceles of the soft palate].
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Vigarios E and Sibaud V
- Subjects
- Adult, Diagnosis, Differential, Female, Humans, Mucocele pathology, Recurrence, Rupture, Spontaneous, Mouth Diseases diagnosis, Mucocele diagnosis, Palate, Soft pathology
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- 2020
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40. [Mucocele of the oral mucous membrane].
- Author
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Essaket S, Hakkou F, and Chbicheb S
- Subjects
- Adult, Humans, Male, Morocco, Mucocele surgery, Mouth Mucosa pathology, Mucocele pathology, Salivary Glands, Minor pathology
- Abstract
Mucoceles of the oral mucous membrane are benign tumoral diseases of the minor salivary glands of the oral mucous membrane. They most commonly occur in the labial mucosa. They can be caused by a break in the epithelium of the gland secreting saliva in the extra-glandular space and forming a pseudo cyst (extravasation mucoceles) or by a block in salivary flow due to an epithelial proliferation of the excretory duct forming salivary cyst (retention cyst). Various therapeutic approaches can be used. Traditional surgical resection is the most effective strategy with low recurrence rate. We here report a clinical case in order to give an update on this lesion. The patient involved in the study was treated in the Department of Dentistry and Oral Surgery, CCTD, Rabat, Morocco., Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts., (© Soukaina Essaket et al.)
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- 2020
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41. The anatomical basis and rational for the transoral approach during the surgical excision of the sublingual salivary gland for the management of plunging ranula.
- Author
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Syebele K and Munzhelele TI
- Subjects
- Follow-Up Studies, HIV Infections complications, Humans, Magnetic Resonance Imaging, Mouth Mucosa, Mucocele diagnosis, Mucocele etiology, Mucocele pathology, Ranula diagnosis, Ranula etiology, Ranula pathology, Retrospective Studies, Salivary Glands diagnostic imaging, Mucocele surgery, Otorhinolaryngologic Surgical Procedures methods, Ranula surgery, Salivary Glands anatomy & histology, Salivary Glands surgery
- Abstract
Purpose: The aim of this study was to illustrate and confirm that the complete intraoral excision of the sublingual gland alone, is anatomically the most rational approach, for the management of plunging ranula., Material and Methods: We retrospectively reviewed clinical charts of diagnosed HIV-infected patients presenting with plunging ranula. The intraoral approach was used for the complete excision of the sublingual gland with evacuation of the pseudocystic content only. Neither extra oral approach, nor ranula dissection / drainage was performed. The surgical procedure was performed using local anesthesia. Pre- and postoperative MRI-scan investigations were recorded. Histological reports were documented to confirm the diagnosis of oral mucocele. Patients were clinically monitored., Results: We identified 90 adults presenting with oral mucocele, type ranula. Seventy (77%) of them were diagnosed with HIV infection. Plunging ranula was recorded in 35 (50%) patients from the latter group. The study enrolled 11 operated patients whose files contained useable data, including an acceptable follow-up period. The postoperative follow-up period ranged from three to 15 months. The clinical and postoperative MRI-scans of operated patients demonstrated satisfactory results. There were neither postoperative complications nor recurrence of ranula reported., Conclusion: The location of the sublingual gland in the floor of the mouth coupled with the physio-pathogenesis of the plunging ranula, makes the transoral complete excision of the offending gland, with the intraoral evacuation of the pseudocyst, anatomically the most rational approach for plunging ranula management. There is no need for cervical approach, ranula dissection and/or postoperative placement of drainage., (Copyright © 2019 Elsevier Inc. All rights reserved.)
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- 2020
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42. Dermoscopy of oral mucocele: three types of extravasation mucoceles
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Ayhan E, Toprak SF, Kaya Ş, and Akkaynak Ş
- Subjects
- Adolescent, Adult, Child, Female, Humans, Male, Mouth Diseases pathology, Mucocele pathology, Young Adult, Dermoscopy methods, Mouth Diseases diagnosis, Mucocele diagnosis
- Abstract
Background/aim: Dermoscopy is a diagnostic tool that assists in imaging the epidermis and dermis. Although it has also started to be used to diagnose nonmelanocytic lesions recently, it has not been tested much on oral mucosal masses, such as oral mucoceles. This study aimed to investigate whether dermoscopy is a valuable tool in diagnosing oral mucoceles., Materials and Methods: In this study, the clinical and dermoscopic features of 21 oral mucocele lesions of 21 patients (11 females, 10 males) aged between 6 and 38 years who were confirmed histopathologically were evaluated., Results: Of the lesions studied, 95.2% (20) were extravasation and 4.8% (1) were retention mucoceles. The nonvascular structures were determined as white areas (61.9%, 13), erythema (57.1%, 12), purplish-gray background (52.3%, 11), ulcer (30%, 8), yellowish- orange areas (23.8%, 5), crust (14.2%, 3), starburst pattern (0.95%, 2), and bleeding (0.47%, 1). Dermoscopically, 40% of extravasation mucoceles were classified as type 1 (8 patients), 25% as type 2 (5 patients), and 35% as type 3 (7 patients)., Conclusion: We concluded that there are 3 types of extravasation mucoceles dermoscopically and clinically, and these types may be stages of transition between each other., Competing Interests: None declared., (This work is licensed under a Creative Commons Attribution 4.0 International License.)
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- 2020
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43. ASO Author Reflections: Mucocele-Like Lesions of the Breast-Excision or No Excision?
- Author
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Moseley TW, Shah SS, Brandt KR, and Huo L
- Subjects
- Breast Neoplasms diagnostic imaging, Breast Neoplasms surgery, Female, Humans, Mucocele diagnostic imaging, Prognosis, Ultrasonography, Mammary, Breast Neoplasms pathology, Decision Making, Mucocele pathology, Mucocele surgery
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- 2019
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44. What is a 'mucocele' of the appendix and how are these lesions best managed? Beware the wolf in sheep's clothing.
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Sakata S and Moran BJ
- Subjects
- Adult, Disease Management, Female, Humans, Male, Appendix pathology, Cecal Diseases pathology, Mucocele pathology
- Published
- 2019
- Full Text
- View/download PDF
45. Mucinous cystadenoma of oral minor salivary glands: Precursor of mucocele?
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Handra-Luca A
- Subjects
- Biopsy, Humans, Immunohistochemistry, Mucocele pathology, Cystadenoma, Mucinous diagnosis, Salivary Gland Neoplasms diagnosis, Salivary Glands, Minor pathology
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- 2019
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46. Clinical Management of Mucocele-Like Lesions of the Breast with Limited or no Epithelial Atypia on Core Biopsy: Experience from Two Institutions.
- Author
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Moseley TW, Shah SS, Nguyen CV, Rosenblat J, Resetkova E, Sneige N, Brandt KR, and Huo L
- Subjects
- Adenocarcinoma, Mucinous surgery, Adult, Aged, Biopsy, Large-Core Needle, Breast Neoplasms surgery, Calcinosis surgery, Carcinoma, Ductal, Breast surgery, Female, Follow-Up Studies, Humans, Middle Aged, Mucocele surgery, Prognosis, Retrospective Studies, Adenocarcinoma, Mucinous pathology, Breast Neoplasms pathology, Calcinosis pathology, Carcinoma, Ductal, Breast pathology, Mucocele pathology
- Abstract
Purpose: Mucocele-like lesions of the breast identified on core biopsy are rare high-risk lesions associated with variable upgrade rates to carcinoma on excision. We aimed to identify the clinicoradiopathological features that can help optimize management of this lesion., Methods: We evaluated 50 mucocele-like lesions identified on core biopsies from two institutions, including 36 with no atypia and 14 with limited atypia. Outcome data from excision or clinicoradiological follow-up were reviewed with core biopsy results., Results: Radiological targets were calcifications in 74% of cases, calcifications with associated mass or density in 16%, and mass in 10%. One of the 16 excised lesions without atypia on core biopsy, which was a mass lesion, was upgraded to mucinous carcinoma on excision. Of the 12 excised lesions with limited atypia, none were upgraded on excision. Among the lesions not excised, 20 without atypia had a median follow-up of 61 months, and 2 with limited atypia had follow-up of 97 and 109 months. None of these 22 patients had new development of their lesions on follow-up. The upgrade rate was 2% in our entire cohort, 3% for lesions without atypia, and 0% for lesions with limited atypia., Conclusions: Clinicoradiological surveillance can be appropriate when a mucocele-like lesion without atypia is identified on core biopsy for a non-mass lesion with pathological-radiological concordance. For mucocele-like lesions with limited atypia, a nonsurgical approach could be considered if the atypia by itself does not warrant excision. The latter recommendation requires careful clinicopathological correlation and support from additional studies.
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- 2019
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47. Frontal pyomucocoele as forehead swelling in a five-year-old girl.
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Williams V, Iyer R, Reshma A, Jayashree M, Mohindra S, and Verma S
- Subjects
- Anti-Bacterial Agents therapeutic use, Child, Preschool, Decompression, Surgical, Female, Frontal Sinus surgery, Humans, Mucocele drug therapy, Mucocele surgery, Treatment Outcome, Forehead pathology, Frontal Sinus pathology, Mucocele pathology
- Abstract
Mucocoeles are slow-growing, locally aggressive, mucus-containing cysts, lined by epithelium, which, when infected, are called pyomucocoeles. We present the case of a five-year-old girl who presented with a frontal pyomucocoele requiring decompression and adequate antibiotics.
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- 2019
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48. Incidental diagnosis on transvaginal ultrasound of appendiceal mucocele arising on low-grade appendiceal mucinous neoplasm.
- Author
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Virgilio BA, Pontrelli G, Trevisan P, Sacchi D, Bernardini T, and Scioscia M
- Subjects
- Adenocarcinoma, Mucinous pathology, Adenocarcinoma, Mucinous surgery, Adult, Appendectomy, Appendiceal Neoplasms pathology, Appendiceal Neoplasms surgery, Female, Humans, Laparoscopy, Mucocele pathology, Mucocele surgery, Treatment Outcome, Adenocarcinoma, Mucinous diagnostic imaging, Appendiceal Neoplasms diagnostic imaging, Incidental Findings, Mucocele diagnostic imaging, Ultrasonography
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- 2019
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49. Predicting Underlying Neoplasms in Appendiceal Mucoceles at CT: Focal Versus Diffuse Luminal Dilatation.
- Author
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Marotta B, Chaudhry S, McNaught A, Quereshy F, Vajpeyi R, Chetty R, and Ghai S
- Subjects
- Adult, Aged, Appendiceal Neoplasms pathology, Appendix pathology, Female, Humans, Male, Middle Aged, Mucocele pathology, Predictive Value of Tests, Retrospective Studies, Appendiceal Neoplasms diagnostic imaging, Appendix diagnostic imaging, Mucocele diagnostic imaging, Tomography, X-Ray Computed methods
- Abstract
OBJECTIVE. The purpose of this study was to determine whether a novel morphologic characteristic of appendiceal mucoceles at CT-focal distal appendiceal dilatation with a segment of morphologically normal appendix proximally-could predict an underlying neoplastic pathologic abnormality before surgery and histopathologic assessment. MATERIALS AND METHODS. A retrospective study was performed that assessed CT cases from 2012 through 2014. Cases showing morphologic features of a mucocele were identified and categorized into two subgroups: focal distal dilatation with a segment of normal appendix proximally and generalized appendiceal dilatation. The underlying histopathologic diagnosis for each case was assessed and categorized as neoplastic or nonneoplastic. Several additional morphologic findings were also assessed. RESULTS. Forty-nine cases with confirmed histopathologic diagnoses were identified. Of those, 20 of 23 (87.0%) cases with the finding of focal distal dilatation had an underlying neoplastic cause, whereas 14 of 26 (53.8%) cases with generalized dilatation had an underlying neoplastic cause ( p = 0.012). The findings of periappendiceal fat stranding ( p = 0.004), mural calcification ( p = 0.006), and degree of luminal dilatation ( p = 0.002) also reached statistical significance. When seen in combination with focal distal dilatation, the positive predictive value for underlying neoplasm approached or reached 100%. CONCLUSION. Our study shows that isolated focal distal appendiceal dilatation with a segment of morphologically normal appendix proximally is significantly associated with an underlying neoplastic histopathologic cause. When seen in combination with mural calcification, a diameter of more than 2 cm, and absence of periappendiceal stranding, an underlying neoplastic cause is strongly suggested.
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- 2019
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- View/download PDF
50. Unusual Changing Calcification Patterns on the Mammogram in a Pure Mucocele-Like Lesion of the Breast: A Case Report.
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Kim SJ and Kim JY
- Subjects
- Adult, Female, Humans, Image-Guided Biopsy, Mammography, Breast Diseases diagnostic imaging, Calcinosis diagnostic imaging, Mucocele diagnostic imaging, Mucocele pathology
- Abstract
BACKGROUND Mucocele-like lesions are rare breast lesions composed of mucin filled cysts and extravasated mucin that frequently undergo calcification. The most common radiologic feature of a mucocele-like lesion is mammographic microcalcifications of indeterminate nature. The present report demonstrated unusual fluctuation of calcification number and a changing pattern of calcification morphology on mammography in a benign mucocele-like lesion. CASE REPORT A 39-year-old female was referred to our breast clinic because of a screening mammography-detected abnormality in her right breast. The magnification mammogram of her right breast revealed approximately 8 cm of multiple adjacent masses accompanying regional coarse heterogeneous microcalcifications in the inner central area, which corresponded to multiple aggregated cystic lesions on sonography. Each cystic lesion had internal echoes of a complex cystic with solid and septated pattern. Although a biopsy was recommended, the patient refused the tissue diagnosis. During the first 12 months, the overall extent of mass and calcifications did not discernably change on magnification mammograms. However, minute focal changes in the calcification number were detected; single coarse calcification disappeared at 6-month follow-up, and new coarse calcification developed at 12-month follow-up. At 24-month follow-up magnification mammogram, coarse calcification overtly increased in number and size, and changed into a large bizarre dystrophic morphology. A pathologic diagnosis of a benign mucocele-like lesion without upgrade to atypia or malignancy was made using ultrasonography-guided vacuum-assisted biopsy and surgical excision. CONCLUSIONS When calcifications accompany cystic masses and chronologically change their morphologic pattern from indeterminate (coarse heterogeneous) to benign (dystrophic), a diagnosis of mucocele-like lesion should be considered.
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- 2019
- Full Text
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