Search

Your search keyword '"Mudd, Pamela A."' showing total 168 results
Start Over Author "Mudd, Pamela A."
168 results on '"Mudd, Pamela A."'

1. Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

Author

Oda, Hirotsugu, Manthiram, Kalpana, Chavan, Pallavi Pimpale, Rieser, Eva, Veli, Önay, Kaya, Öykü, Rauch, Charles, Nakabo, Shuichiro, Kuehn, Hye Sun, Swart, Mariël, Wang, Yanli, Çelik, Nisa Ilgim, Molitor, Anne, Ziaee, Vahid, Movahedi, Nasim, Shahrooei, Mohammad, Parvaneh, Nima, Alipour-olyei, Nasrin, Carapito, Raphael, Xu, Qin, Preite, Silvia, Beck, David B., Chae, Jae Jin, Nehrebecky, Michele, Ombrello, Amanda K., Hoffmann, Patrycja, Romeo, Tina, Deuitch, Natalie T., Matthíasardóttir, Brynja, Mullikin, James, Komarow, Hirsh, Stoddard, Jennifer, Niemela, Julie, Dobbs, Kerry, Sweeney, Colin L., Anderton, Holly, Lawlor, Kate E., Yoshitomi, Hiroyuki, Yang, Dan, Boehm, Manfred, Davis, Jeremy, Mudd, Pamela, Randazzo, Davide, Tsai, Wanxia Li, Gadina, Massimo, Kaplan, Mariana J., Toguchida, Junya, Mayer, Christian T., Rosenzweig, Sergio D., Notarangelo, Luigi D., Iwai, Kazuhiro, Silke, John, Schwartzberg, Pamela L., Boisson, Bertrand, Casanova, Jean-Laurent, Bahram, Seiamak, Rao, Anand Prahalad, Peltzer, Nieves, Walczak, Henning, Lalaoui, Najoua, Aksentijevich, Ivona, and Kastner, Daniel L.

Published
2024
Full Text
View/download PDF

2. Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children

Author

Xu, Qin, Milanez-Almeida, Pedro, Martins, Andrew J., Radtke, Andrea J., Hoehn, Kenneth B., Oguz, Cihan, Chen, Jinguo, Liu, Can, Tang, Juanjie, Grubbs, Gabrielle, Stein, Sydney, Ramelli, Sabrina, Kabat, Juraj, Behzadpour, Hengameh, Karkanitsa, Maria, Spathies, Jacquelyn, Kalish, Heather, Kardava, Lela, Kirby, Martha, Cheung, Foo, Preite, Silvia, Duncker, Patrick C., Kitakule, Moses M., Romero, Nahir, Preciado, Diego, Gitman, Lyuba, Koroleva, Galina, Smith, Grace, Shaffer, Arthur, McBain, Ian T., McGuire, Peter J., Pittaluga, Stefania, Germain, Ronald N., Apps, Richard, Schwartz, Daniella M., Sadtler, Kaitlyn, Moir, Susan, Chertow, Daniel S., Kleinstein, Steven H., Khurana, Surender, Tsang, John S., Mudd, Pamela, Schwartzberg, Pamela L., and Manthiram, Kalpana

Published
2023
Full Text
View/download PDF

10. Common genetic susceptibility loci link PFAPA syndrome, Behçet’s disease, and recurrent aphthous stomatitis

Author

The Genomic Ascertainment Cohort, Manthiram, Kalpana, Preite, Silvia, Dedeoglu, Fatma, Demir, Selcan, Ozen, Seza, Edwards, Kathryn M., Lapidus, Sivia, Katz, Alexander E., Feder, Henry M., Lawton, Maranda, Licameli, Greg R., Wright, Peter F., Le, Julie, Barron, Karyl S., Ombrello, Amanda K., Barham, Beverly, Romeo, Tina, Jones, Anne, Srinivasalu, Hemalatha, Mudd, Pamela A., DeBiasi, Roberta L., Gül, Ahmet, Marshall, Gary S., Jones, Olcay Y., Chandrasekharappa, Settara C., Stepanovskiy, Yuriy, Ferguson, Polly J., Schwartzberg, Pamela L., Remmers, Elaine F., and Kastner, Daniel L.

Published
2020

14. 2368. SARS-CoV-2 mRNA vaccination induces B cell immunity in the tonsils and adenoids of children

Author

Xu, Qin, primary, Mudd, Pamela, additional, Behzadpour, Hengameh, additional, Bellusci, Lorenza, additional, Grubbs, Gabrielle, additional, Pourhashemi, Sara, additional, Tang, Juanjie, additional, Liu, Can, additional, Newman, Daniel, additional, Shi, Lihong, additional, Milanez-Almeida, Pedro, additional, Kardava, Lela, additional, Tsang, John, additional, Moir, Susan, additional, Khurana, Surender, additional, Schwartzberg, Pamela, additional, and Manthiram, Kalpana, additional

Published
2023
Full Text
View/download PDF

17. mRNA vaccination induces persistent pharyngeal mucosal B cell responses to SARS-CoV-2 in children

Author

Xu, Qin, primary, Mudd, Pamela, additional, Behzadpour, Hengameh, additional, Newman, Daniel, additional, Bellusci, Lorenza, additional, Grubbs, Gabrielle, additional, Tang, Juanjie, additional, Liu, Can, additional, Milanez-Almeida, Pedro, additional, Martins, Andrew, additional, Kardava, Lela, additional, Moir, Susan, additional, Khurana, Surender, additional, Schwartzberg, Pamela, additional, and Manthiram, Kalpana, additional

Published
2023
Full Text
View/download PDF

21. Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children

Author

Xu, Qin, primary, Milanez-Almeida, Pedro, additional, Martins, Andrew J., additional, Radtke, Andrea J., additional, Hoehn, Kenneth B., additional, Oguz, Cihan, additional, Chen, Jinguo, additional, Liu, Can, additional, Tang, Juanjie, additional, Grubbs, Gabrielle, additional, Stein, Sydney, additional, Ramelli, Sabrina, additional, Kabat, Juraj, additional, Behzadpour, Hengameh, additional, Karkanitsa, Maria, additional, Spathies, Jacquelyn, additional, Kalish, Heather, additional, Kardava, Lela, additional, Kirby, Martha, additional, Cheung, Foo, additional, Preite, Silvia, additional, Duncker, Patrick C., additional, Kitakule, Moses M., additional, Romero, Nahir, additional, Preciado, Diego, additional, Gitman, Lyuba, additional, Koroleva, Galina, additional, Smith, Grace, additional, Shaffer, Arthur, additional, McBain, Ian T., additional, McGuire, Peter J., additional, Pittaluga, Stefania, additional, Germain, Ronald N., additional, Apps, Richard, additional, Schwartz, Daniella M., additional, Sadtler, Kaitlyn, additional, Moir, Susan, additional, Chertow, Daniel S., additional, Kleinstein, Steven H., additional, Khurana, Surender, additional, Tsang, John S., additional, Mudd, Pamela, additional, Schwartzberg, Pamela L., additional, and Manthiram, Kalpana, additional

Published
2022
Full Text
View/download PDF

22. Human LUBAC deficiency leads to autoinflammation and immunodeficiency by dysregulation in TNF-mediated cell death

Author

Oda, Hirotsugu, primary, Manthiram, Kalpana, additional, Chavan, Pallavi Pimpale, additional, Nakabo, Shuichiro, additional, Kuehn, Hye Sun, additional, Beck, David B., additional, Chae, Jae Jin, additional, Nehrebecky, Michele, additional, Ombrello, Amanda K., additional, Romeo, Tina, additional, Deuitch, Natalie, additional, Matthíasardóttir, Brynja, additional, Mullikin, Jim, additional, Stoddard, Jennifer, additional, Niemela, Julie, additional, Anderton, Holly, additional, Lawlor, Kate E., additional, Yoshitomi, Hiroyuki, additional, Yang, Dan, additional, Boehm, Manfred, additional, Davis, Jeremy, additional, Mudd, Pamela, additional, Randazzo, Davide, additional, Tsai, Wanxia Li, additional, Gadina, Massimo, additional, Kaplan, Mariana J., additional, Toguchida, Junya, additional, Mayer, Christian, additional, Rosenzweig, Sergio D., additional, Iwai, Kazuhiro, additional, Silke, John, additional, Boisson, Bertrand, additional, Casanova, Jean-Laurent, additional, Rao, Anand, additional, Lalaoui, Najoua, additional, Aksentijevich, Ivona, additional, and Kastner, Daniel L., additional

Published
2022
Full Text
View/download PDF

28. Managing the Destructive Foreign Body: Water Beads in the Ear (A Case Series) and Literature Review.

Author

Zalzal, Habib G., Ryan, Matthew, Reilly, Brian, and Mudd, Pamela

Subjects
FOREIGN body reaction, GENERAL anesthesia, EAR canal, TIME, TYMPANIC membrane perforation, DEAFNESS, TERTIARY care, RETROSPECTIVE studies, ACQUISITION of data, TREATMENT effectiveness, MEDICAL records, LABYRINTHITIS, FOREIGN bodies, SURGERY, DIAGNOSIS
Abstract

Objective: To characterize our experience with super-absorbent polymer beads placed in the external auditory canal to better understand the damage caused and subsequent management required. Methods: Retrospective chart review of pediatric patients at 2 separate tertiary referral centers. Results: Seven patients were identified as having placed super-absorbent polymer beads in the external auditory canal, 6 of whom required removal under general anesthesia. Three patients did not suffer otologic trauma or hearing loss (average foreign body duration <72 hours). Four patients experienced severe otologic complications (average foreign body duration >1 week), all of whom were treated with otologic drops prior to bead identification. Of this severe complication group, 3 patients had restored hearing after surgical intervention, while 1 patient suffered profound hearing loss secondary to labyrinthitis ossificans. Conclusion: Early recognition of otologic foreign bodies is important, particularly if expansile water-bead is suspected. Depending on timeframe, water beads are highly destructive to the middle ear structures, and most patients will require surgical intervention. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

29. Examining multi‐level immune response to determine prevalence of COVID‐19 in pediatric tonsillectomy.

Author

Mudd, Pamela, Romero, Nahir, Behzadpour, Hengameh, Xu, Qin, Rana, Md Sohel, Gitman, Lyuba, Preciado, Diego, Karkanitsa, Maria, Spathies, Jacquelyn, Sadtler, Kaitlyn, Kalish, Heather, Schwartzberg, Pamela L., and Manthiram, Kalpana

Abstract

Objective: To determine the prevalence of COVID‐19 in a cohort of children undergoing tonsillectomy through assessment of B cell immune responses to SARS‐CoV‐2 in both peripheral blood and tonsil tissue. Methods: In this cohort study at a tertiary pediatric hospital (Children's National Hospital) in Washington, DC, we recruited 100 children undergoing tonsillectomy from late September 2020 to January 2021. Serum, peripheral blood cells, and tonsil tissue were collected and examined for immune reactivity to SARS‐CoV‐2. Parent‐reported clinical histories were compared to antibody and B‐cell responses. Results: Among 100 children undergoing tonsillectomy, 19% had evidence of immune responses to SARS‐CoV‐2 (CoV2+), indicating prior COVID‐19. In all seropositive participants, we detected SARS‐CoV‐2 specific B cells in both peripheral blood mononuclear cells and tonsils, providing evidence for tissue‐specific immunity in these children. Of the 19, 63% reported no known history of COVID‐19, and an additional 3 were asymptomatic or unaware of an acute infection when detected on pre‐surgery screen. Hispanic children represented 74% of CoV2+ subjects compared to 37% of the full cohort. 100% of CoV2+ children lived in a zip code with poverty level >10%. Conclusions: Nearly one‐fifth of children undergoing tonsillectomy at an urban U.S. hospital had evidence of prior COVID‐19 during the early pandemic, with the majority unaware of prior infection. Our results underscore the ethnic and socio‐economic disparities of COVID‐19. We found concordant evidence of humoral immune responses in children in both blood and tonsil tissue, providing evidence of local immune responses in the upper respiratory tract. Level of Evidence: 3 Laryngoscope, 133:1993–1999, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

30. Biallelic human SHARPINloss of function induces autoinflammation and immunodeficiency

Author

Oda, Hirotsugu, Manthiram, Kalpana, Chavan, Pallavi Pimpale, Rieser, Eva, Veli, Önay, Kaya, Öykü, Rauch, Charles, Nakabo, Shuichiro, Kuehn, Hye Sun, Swart, Mariël, Wang, Yanli, Çelik, Nisa Ilgim, Molitor, Anne, Ziaee, Vahid, Movahedi, Nasim, Shahrooei, Mohammad, Parvaneh, Nima, Alipour-olyei, Nasrin, Carapito, Raphael, Xu, Qin, Preite, Silvia, Beck, David B., Chae, Jae Jin, Nehrebecky, Michele, Ombrello, Amanda K., Hoffmann, Patrycja, Romeo, Tina, Deuitch, Natalie T., Matthíasardóttir, Brynja, Mullikin, James, Komarow, Hirsh, Stoddard, Jennifer, Niemela, Julie, Dobbs, Kerry, Sweeney, Colin L., Anderton, Holly, Lawlor, Kate E., Yoshitomi, Hiroyuki, Yang, Dan, Boehm, Manfred, Davis, Jeremy, Mudd, Pamela, Randazzo, Davide, Tsai, Wanxia Li, Gadina, Massimo, Kaplan, Mariana J., Toguchida, Junya, Mayer, Christian T., Rosenzweig, Sergio D., Notarangelo, Luigi D., Iwai, Kazuhiro, Silke, John, Schwartzberg, Pamela L., Boisson, Bertrand, Casanova, Jean-Laurent, Bahram, Seiamak, Rao, Anand Prahalad, Peltzer, Nieves, Walczak, Henning, Lalaoui, Najoua, Aksentijevich, Ivona, and Kastner, Daniel L.

Abstract

The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpinleads to severe dermatitis due to excessive keratinocyte cell death. Here, we report two individuals with SHARPIN deficiency who manifest autoinflammatory symptoms but unexpectedly no dermatological problems. Fibroblasts and B cells from these individuals showed attenuated canonical NF-κB responses and a propensity for cell death mediated by TNF superfamily members. Both SHARPIN-deficient and HOIP-deficient individuals showed a substantial reduction of secondary lymphoid germinal center B cell development. Treatment of one SHARPIN-deficient individual with anti-TNF therapies led to complete clinical and transcriptomic resolution of autoinflammation. These findings underscore the critical function of the LUBAC as a gatekeeper for cell death-mediated immune dysregulation in humans.

Published
2024
Full Text
View/download PDF

31. Examining multi‐level immune response to determine prevalence of COVID ‐19 in pediatric tonsillectomy

Author

Mudd, Pamela, primary, Romero, Nahir, additional, Behzadpour, Hengameh, additional, Xu, Qin, additional, Rana, Md Sohel, additional, Gitman, Lyuba, additional, Preciado, Diego, additional, Karkanitsa, Maria, additional, Spathies, Jacquelyn, additional, Sadtler, Kaitlyn, additional, Kalish, Heather, additional, Schwartzberg, Pamela L., additional, and Manthiram, Kalpana, additional

Published
2022
Full Text
View/download PDF

37. Robust, persistent adaptive immune responses to SARS-CoV-2 in the oropharyngeal lymphoid tissue of children

Author

Manthiram, Kalpana, primary, Xu, Qin, additional, Milanez-Almeida, Pedro, additional, Martins, Andrew, additional, Radtke, Andrea, additional, Hoehn, Kenneth, additional, Chen, Jinguo, additional, Liu, Can, additional, Tang, Juanjie, additional, Grubbs, Gabrielle, additional, Stein, Sydney, additional, Ramelli, Sabrina, additional, Kabat, Juraj, additional, Behzadpour, Hengameh, additional, Karkanitsa, Maria, additional, Spathies, Jacquelyn, additional, Kalish, Heather, additional, Kardava, Lela, additional, Kirby, Martha, additional, Cheung, Foo, additional, Preite, Silvia, additional, Duncker, Patrick, additional, Romero, Nahir, additional, Preciado, Diego, additional, Gitman, Lyuba, additional, Koroleva, Galina, additional, Smith, Grace, additional, Shaffer, Arthur, additional, McBain, Ian, additional, Pittaluga, Stefania, additional, Germain, Ronald, additional, Apps, Richard, additional, Sadtler, Kaitlyn, additional, Moir, Susan, additional, Chertow, Daniel, additional, Kleinstein, Steven, additional, Khurana, Surender, additional, Tsang, John, additional, Mudd, Pamela, additional, and Schwartzberg, Pamela, additional

Published
2022
Full Text
View/download PDF

38. Multi‐Institutional Study of Patient‐Reported Outcomes of Paradoxical Vocal Fold Motion.

Author

Schonman, Ian, Mudd, Pamela A., Ivancic, Ryan, Ryan, Marisa A., Ongkasuwan, Julina, Prager, Jeremy, Smith, Marshall E., Goudy, Steven L., Rana, Md Sohel, Wiet, Gregory J., and Bauman, Nancy M.

Abstract

Objective: To explore patient‐reported outcome measures of pediatric paradoxical vocal fold motion through a multi‐institutional study of geographically diverse United States medical facilities to assess long‐term management and outcomes. Methods: Eligible participants >8 years of age diagnosed with PVFM over a 10‐year period from 7 tertiary pediatric hospitals were invited to complete a survey addressing study objectives. Results: 65 participants completed the survey, of whom 80% were female, 75% reported a 3.5 grade point average or better, and 75% identified as competitive athletes or extremely athletic individuals. Participants rated their perceived efficacy of 13 specific treatments. Only five treatments were considered effective by a majority of the participants who tried them. The treatments that participants tried most often were breathing exercises (89.2%), bronchodilator treatments (45%), and allergy medications (35.4%). 78.8% of participants reported receiving more than one treatment and 25% reported receiving a combination of bronchodilators, anticholinergics, and steroids. At the time of PVFM diagnosis, 38% of participants had no idea when their symptoms would completely resolve. 23.3% of participants did not experience symptom resolution until greater than 1 year after diagnosis. Conclusions: Traditional management tools such as breathing exercises and biofeedback treatments may not provide the long‐term benefit that providers anticipate. In addition to these commonly used management strategies, highly efficacious techniques such as counseling and lifestyle management should be incorporated into the long‐term management of patients whose symptoms are refractory to traditional care. Level of Evidence: 4 Laryngoscope, 133:970–976, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

45. Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement

Author

Sidell, Douglas R., primary, Balakrishnan, Karthik, additional, Best, Simon R., additional, Zur, Karen, additional, Buckingham, Julia, additional, De Alarcon, Alessandro, additional, Baroody, Fuad M., additional, Bock, Jonathan M., additional, Boss, Emily F., additional, Bower, Charles M., additional, Campisi, Paolo, additional, Chen, Sharon F., additional, Clarke, Jeffrey M., additional, Clarke, Kevin D., additional, Cocciaglia, Alejandro, additional, Cotton, Robin T., additional, Cuestas, Giselle, additional, Davis, Kara L., additional, DeFago, Victor H., additional, Dikkers, Frederik G., additional, Dossans, Ines, additional, Florez, Walter, additional, Fox, Elizabeth, additional, Friedman, Aaron D., additional, Grant, Nazaneen, additional, Hamdi, Osama, additional, Hogikyan, Norman D., additional, Johnson, Kaalan, additional, Johnson, Liane B., additional, Johnson, Romaine F., additional, Kelly, Peggy, additional, Klein, Adam M., additional, Lawlor, Claire M., additional, Leboulanger, Nicolas, additional, Levy, Alejandro G., additional, Lam, Derek, additional, Licameli, Greg R., additional, Long, Steve, additional, Lott, David G., additional, Manrique, Dayse, additional, McMurray, James Scott, additional, Meister, Kara D., additional, Messner, Anna H., additional, Mohr, Michael, additional, Mudd, Pamela, additional, Mortelliti, Anthony J., additional, Novakovic, Daniel, additional, Ongkasuwan, Julian, additional, Peer, Shazia, additional, Piersiala, Krysztof, additional, Prager, Jeremy D., additional, Pransky, Seth M., additional, Preciado, Diego, additional, Raynor, Tiffany, additional, Rinkel, Rico N. P. M., additional, Rodriguez, Hugo, additional, Rodríguez, Verónica P., additional, Russell, John, additional, Scatolini, María Laura, additional, Scheffler, Patrick, additional, Smith, David F., additional, Smith, Lee P., additional, Smith, Marshall E., additional, Smith, Richard J. H., additional, Sorom, Abraham, additional, Steinberg, Amalia, additional, Stith, John A., additional, Thompson, Dana, additional, Thompson, Jerome W., additional, Varela, Patricio, additional, White, David R., additional, Wineland, Andre M., additional, Yang, Christina J., additional, Zdanski, Carlton J., additional, and Derkay, Craig S., additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results