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9 results on '"Mudenda, Twig"'

1. The Role of Rural Health Centres in the Detection and Management of Malaria Outbreaks in a Low Transmission Setting of Choma District, Zambia

Author

lubinda, Mukuma, primary, Matoba, Japhet, additional, Sing’anga, Caison, additional, G. Meleki, Emmanuel, additional, Mukosha, Rakel, additional, Mudenda, Twig, additional, Simubali, Limonty, additional, M. Mburu, Monicah, additional, Simulundu, Edgar, additional, Thuma, Phillip, additional, and Shiff, Clive, additional

Published
2023
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3. Policy Implications of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe

Author

Wesolowski, Amy, primary, Ippolito, Matthew M., additional, Gebhardt, Mary E., additional, Ferriss, Ellen, additional, Schue, Jessica L., additional, Kobayashi, Tamaki, additional, Chaponda, Mike, additional, Kabuya, Jean-Bertin, additional, Muleba, Mbanga, additional, Mburu, Monicah, additional, Matoba, Japhet, additional, Musonda, Michael, additional, Katowa, Ben, additional, Lubinda, Mukuma, additional, Hamapumbu, Harry, additional, Simubali, Limonty, additional, Mudenda, Twig, additional, Shields, Timothy M., additional, Hackman, Andre, additional, Shiff, Clive, additional, Coetzee, Maureen, additional, Koekemoer, Lizette L., additional, Munyati, Shungu, additional, Gwanzura, Lovemore, additional, Mutambu, Susan, additional, Stevenson, Jennifer C., additional, Thuma, Philip E., additional, Norris, Douglas E., additional, Bailey, Jeffrey A., additional, Juliano, Jonathan J., additional, Chongwe, Gershom, additional, Mulenga, Modest, additional, Simulundu, Edgar, additional, Mharakurwa, Sungano, additional, Agre, Peter, additional, Moss, William J., additional, and _, _, additional

Published
2022
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4. Scientific Findings of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe

Author

Ippolito, Matthew M., primary, Gebhardt, Mary E., additional, Ferriss, Ellen, additional, Schue, Jessica L., additional, Kobayashi, Tamaki, additional, Chaponda, Mike, additional, Kabuya, Jean-Bertin, additional, Muleba, Mbanga, additional, Mburu, Monicah, additional, Matoba, Japhet, additional, Musonda, Michael, additional, Katowa, Ben, additional, Lubinda, Mukuma, additional, Hamapumbu, Harry, additional, Simubali, Limonty, additional, Mudenda, Twig, additional, Wesolowski, Amy, additional, Shields, Timothy M., additional, Hackman, Andre, additional, Shiff, Clive, additional, Coetzee, Maureen, additional, Koekemoer, Lizette L., additional, Munyati, Shungu, additional, Gwanzura, Lovemore, additional, Mutambu, Susan, additional, Stevenson, Jennifer C., additional, Thuma, Philip E., additional, Norris, Douglas E., additional, Bailey, Jeffrey A., additional, Juliano, Jonathan J., additional, Chongwe, Gershom, additional, Mulenga, Modest, additional, Simulundu, Edgar, additional, Mharakurwa, Sungano, additional, Agre, Peter C., additional, Moss, William J., additional, and _, _, additional

Published
2022
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5. Understudied Anophelines Contribute to Malaria Transmission in a Low-Transmission Setting in the Choma District, Southern Province, Zambia

Author

Gebhardt, Mary E., primary, Searle, Kelly M., additional, Kobayashi, Tamaki, additional, Shields, Timothy M., additional, Hamapumbu, Harry, additional, Simubali, Limonty, additional, Mudenda, Twig, additional, Thuma, Philip E., additional, Stevenson, Jennifer C., additional, Moss, William J., additional, Norris, Douglas E., additional, and _, _, additional

Published
2022
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6. Multiple Novel Clades of Anopheline Mosquitoes Caught Outdoors in Northern Zambia

Author

Jones, Christine M., primary, Ciubotariu, Ilinca I., additional, Muleba, Mbanga, additional, Lupiya, James, additional, Mbewe, David, additional, Simubali, Limonty, additional, Mudenda, Twig, additional, Gebhardt, Mary E., additional, Carpi, Giovanna, additional, Malcolm, Ashley N., additional, Kosinski, Kyle J., additional, Romero-Weaver, Ana L., additional, Stevenson, Jennifer C., additional, Lee, Yoosook, additional, and Norris, Douglas E., additional

Published
2021
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8. Phylogenetic Complexity of Morphologically Identified Anopheles squamosus in Southern Zambia.

Author

Hoffman, Jordan E., Ciubotariu, Ilinca I., Simubali, Limonty, Mudenda, Twig, Moss, William J., Carpi, Giovanna, Norris, Douglas E., Stevenson, Jennifer C., and Smartt, Chelsea T.

Subjects
ANOPHELES, FORAGING behavior, MALARIA, INSECT traps, WATERSHEDS, VECTOR control, MOLECULAR phylogeny, CERATOPOGONIDAE, AEDES aegypti
Abstract

Simple Summary: Despite dramatic reductions in malaria cases in the catchment area of Macha Hospital, Choma District, Southern Province in Zambia, prevalence has remained near 1–2% by RDT for the past several years. To investigate residual malaria transmission in the area, this study focuses on the relative abundance, foraging behavior, and phylogenetic relationships of Anopheles squamosus specimens. Morphological identification, molecular verification of anopheline species, and blood meal source were determined on individual samples. Data from these collections supported earlier studies demonstrating An. squamosus to be primarily exophagic and zoophilic, allowing them to evade current control measures. The phylogenetic relationships generated from the specimens in this study supported the hypothesis of cryptic taxa among An. squamosus specimens, which further emphasizes the importance of molecular identification of vectors. The primarily exophagic behavior of An. squamosus in these collections also highlights that indoor vector control strategies will not be sufficient for elimination of malaria in southern Zambia. Despite dramatic reductions in malaria cases in the catchment area of Macha Hospital, Choma District, Southern Province in Zambia, prevalence has remained near 1–2% by RDT for the past several years. To investigate residual malaria transmission in the area, this study focuses on the relative abundance, foraging behavior, and phylogenetic relationships of Anopheles squamosus specimens. In 2011, higher than expected rates of anthropophily were observed among "zoophilic" An. squamosus, a species that had sporadically been found to contain Plasmodium falciparum sporozoites. The importance of An. squamosus in the region was reaffirmed in 2016 when P. falciparum sporozoites were detected in numerous An. squamosus specimens. This study analyzed Centers for Disease Control (CDC) light trap collections of adult mosquitoes from two collection schemes: one performed as part of a reactive-test-and-treat program and the second performed along a geographical transect. Morphological identification, molecular verification of anopheline species, and blood meal source were determined on individual samples. Data from these collections supported earlier studies demonstrating An. squamosus to be primarily exophagic and zoophilic, allowing them to evade current control measures. The phylogenetic relationships generated from the specimens in this study illustrate the existence of well supported clade structure among An. squamosus specimens, which further emphasizes the importance of molecular identification of vectors. The primarily exophagic behavior of An. squamosus in these collections also highlights that indoor vector control strategies will not be sufficient for elimination of malaria in southern Zambia. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Detection of Plasmodium falciparum Infection in Anopheles squamosus (Diptera: Culicidae) in an Area Targeted for Malaria Elimination, Southern Zambia

Author

Stevenson, Jennifer C., Simubali, Limonty, Mbambara, Saidon, Musonda, Michael, Mweetwa, Sydney, Mudenda, Twig, Pringle, Julia C., Jones, Christine M., and Norris, Douglas E.

Abstract

Southern Zambia is the focus of strategies to create malaria-free zones. Interventions being rolled out include test and treat strategies and distribution of insecticide-treated bed nets that target vectors that host-seek indoors and late at night. In Macha, Choma District, collections of mosquitoes were made outdoors using barrier screens within homesteads or UV bulb light traps set next to goats, cattle, or chickens during the rainy season of 2015. Anopheline mosquitoes were identified to species using molecular methods and Plasmodium falciparum infectivity was determined by ELISA and real-time qPCR methods. More than 40% of specimens caught were identified as Anopheles squamosus Theobald, 1901 of which six were found harboring malaria parasites. A single sample, morphologically identified as Anopheles coustani Laveran, 1900, was also found to be infectious. All seven specimens were caught outdoors next to goat pens. Parasite-positive specimens as well as a subset of An. squamosus specimens from either the same study or archive collections from the same area underwent sequencing of the mitochondrial cytochrome oxidase subunit I gene. Maximum parsimony trees constructed from the aligned sequences indicated presence of at least two clades of An. squamosus with infectious specimens falling in each clade. The single infectious specimen identified morphologically as An. coustani could not be matched to reference sequences. This is the first report from Zambia of infections in An. squamosus, a species which is described in literature to display exophagic traits. The bionomic characteristics of this species needs to be studied further to fully evaluate the implications for indoor-targeted vector control.

Published
2016
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