1. Primary CNS lymphoma in immunocompetent: a review of literature and our experience from Kashmir
- Author
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Muhammad Maqbool, Anil Dhar, Sumaira Qadiri, Altaf U. Ramzan, Ahmad Rayees, Khursheed Nayil, Syed Besina, Abdul Rashid Lone, Muhammad Baba Khalil, Rumana Makhdoomi, Nasima Chanda, and Altaf Rehman Kirmani
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Pathology ,Lymphoma ,Biopsy ,India ,Primary CNS Lymphoma ,Radiation oncology ,medicine ,Humans ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Female ,Neurology (clinical) ,Neurosurgery ,Immunocompetence ,business ,Tomography, X-Ray Computed ,After treatment - Abstract
Aim To study the clinicopathological aspects of primary CNS lymphoma in immunocompetent patients. Material and methods Sixteen patients with primary CNS lymphoma were analyzed for their clinico-pathological characteristics and followed-up for the treatment and subsequent management in Neurosurgery, and Medical and Radiation Oncology. Results The fronto-parietal region was the commonest location of CNS lymphoma; four cases of cerebellar lymphoma were seen. Our patients were relatively young with a mean age of 48 years and an age range of 35-60 years. Females outnumbered males with a ratio of 2.7:1. The commonest presentation was focal neurological-deficits and features of raised intracranial pressure. All the patients histologically had diffuse large B-cell lymphoma. Radiologically, most presented as disc-enhancing lesions. Two patients had multiple lesions. Most of the patients (10) died within a mean of 4.4 months (range 2 weeks-16 months). Conclusion Primary CNS lymphoma is seen in immunocompetent patients as well. Relapse is common after treatment and the overall prognosis is unfavorable.
- Published
- 2011