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Urban aquifers are experiencing increasing pressures from climate change, land-use change, and abstraction, consequently, altering groundwater levels and threatening sustainable water availability, consumption, and utilization. Sustainability in such areas requires the adaptation of groundwater resources to these stressors. Consequently, this research made projections about future climate, land use, and abstraction, examines how these drives will affect groundwater levels, and then proposes adaptation strategies to reduce the impact on Lahore’s groundwater resources. The objectives are achieved using an integrated modeling framework involving applications of Soil Water Assessment Tool (SWAT) and MODFLOW models. The results indicated a projected rise in Tmin by ~2.03 °C and Tmax by ~1.13 °C by 2100 under medium (RCP 4.5) and high-end (RCP 8.5) scenarios, respectively. Future precipitation changes for mid, near and far periods are projected to be −1.0%, 25%, and 24.5% under RCP4.5, and −17.5%, 27.5%, and 29.0% under RCP8.5, respectively. The built-up area in the Lahore division will dominate agricultural land in the future with an expansion from 965 m2 to 3716 km2 by the year 2100 under R1S1 (R2S2) land-use change scenarios (significant at p = 5%). The future population of the Lahore division will increase from 6.4 M to 24.6 M (28.7 M) by the year 2100 under SSP1 (SSP3) scenarios (significant at p = 5%). Groundwater level in bult-up areas will be projected to decline from 185 m to 125 m by 2100 due to increasing groundwater abstraction and expansion in the impermeable surface under all scenarios. In contrast, agricultural areas show a fluctuating trend with a slight increase in groundwater level due to decreasing abstraction and multiple recharge sources under combined scenarios. The results of this study can be a way forward for groundwater experts and related institutions to understand the potential situation of groundwater resources in the Lahore division and implement adaptation strategies to counteract diminishing groundwater resources.