Search

Your search keyword '"Muhlestein J"' showing total 362 results
Start Over Author "Muhlestein J"
362 results on '"Muhlestein J"'

1. Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis.

Author

Weinstock, Joshua, Gopakumar, Jayakrishnan, Burugula, Bala, Uddin, Md, Jahn, Nikolaus, Belk, Julia, Bouzid, Hind, Daniel, Bence, Miao, Zhuang, Ly, Nghi, Mack, Taralynn, Luna, Sofia, Prothro, Katherine, Mitchell, Shaneice, Laurie, Cecelia, Broome, Jai, Taylor, Kent, Guo, Xiuqing, Sinner, Moritz, von Falkenhausen, Aenne, Kääb, Stefan, Shuldiner, Alan, OConnell, Jeffrey, Lewis, Joshua, Boerwinkle, Eric, Barnes, Kathleen, Chami, Nathalie, Kenny, Eimear, Loos, Ruth, Fornage, Myriam, Hou, Lifang, Lloyd-Jones, Donald, Redline, Susan, Cade, Brian, Psaty, Bruce, Bis, Joshua, Brody, Jennifer, Silverman, Edwin, Yun, Jeong, Qiao, Dandi, Palmer, Nicholette, Freedman, Barry, Bowden, Donald, Cho, Michael, DeMeo, Dawn, Vasan, Ramachandran, Yanek, Lisa, Becker, Lewis, Kardia, Sharon, Peyser, Patricia, He, Jiang, Rienstra, Michiel, Van der Harst, Pim, Kaplan, Robert, Heckbert, Susan, Smith, Nicholas, Wiggins, Kerri, Arnett, Donna, Irvin, Marguerite, Tiwari, Hemant, Cutler, Michael, Knight, Stacey, Muhlestein, J, Correa, Adolfo, Raffield, Laura, Gao, Yan, de Andrade, Mariza, Rotter, Jerome, Rich, Stephen, Tracy, Russell, Konkle, Barbara, Johnsen, Jill, Wheeler, Marsha, Smith, J, Melander, Olle, Nilsson, Peter, Custer, Brian, Duggirala, Ravindranath, Curran, Joanne, Blangero, John, McGarvey, Stephen, Williams, L, Xiao, Shujie, Yang, Mao, Gu, C, Chen, Yii-Der, Lee, Wen-Jane, Kane, John, Pullinger, Clive, Shoemaker, M, Darbar, Dawood, Roden, Dan, Albert, Christine, Kooperberg, Charles, Zhou, Ying, Manson, JoAnn, Desai, Pinkal, Johnson, Andrew, Mathias, Rasika, and Blackwell, Thomas

Subjects
Animals, Humans, Mice, Alleles, Clonal Hematopoiesis, Genome-Wide Association Study, Hematopoiesis, Hematopoietic Stem Cells, Mutation, Promoter Regions, Genetic
Abstract

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs), leading to clonal haematopoiesis1. These lesions are precursors for blood cancers2-6, but the basis of their fitness advantage remains largely unknown, partly owing to a paucity of large cohorts in which the clonal expansion rate has been assessed by longitudinal sampling. Here, to circumvent this limitation, we developed a method to infer the expansion rate from data from a single time point. We applied this method to 5,071 people with clonal haematopoiesis. A genome-wide association study revealed that a common inherited polymorphism in the TCL1A promoter was associated with a slower expansion rate in clonal haematopoiesis overall, but the effect varied by driver gene. Those carrying this protective allele exhibited markedly reduced growth rates or prevalence of clones with driver mutations in TET2, ASXL1, SF3B1 and SRSF2, but this effect was not seen in clones with driver mutations in DNMT3A. TCL1A was not expressed in normal or DNMT3A-mutated HSCs, but the introduction of mutations in TET2 or ASXL1 led to the expression of TCL1A protein and the expansion of HSCs in vitro. The protective allele restricted TCL1A expression and expansion of mutant HSCs, as did experimental knockdown of TCL1A expression. Forced expression of TCL1A promoted the expansion of human HSCs in vitro and mouse HSCs in vivo. Our results indicate that the fitness advantage of several commonly mutated driver genes in clonal haematopoiesis may be mediated by TCL1A activation.

Published
2023

2. International consensus on fasting terminology

Author

Koppold, Daniela A., Breinlinger, Carolin, Hanslian, Etienne, Kessler, Christian, Cramer, Holger, Khokhar, Anika Rajput, Peterson, Courtney M., Tinsley, Grant, Vernieri, Claudio, Bloomer, Richard J., Boschmann, Michael, Bragazzi, Nicola L., Brandhorst, Sebastian, Gabel, Kelsey, Goldhamer, Alan C., Grajower, Martin M., Harvie, Michelle, Heilbronn, Leonie, Horne, Benjamin D., Karras, Spyridon N., Langhorst, Jost, Lischka, Eva, Madeo, Frank, Mitchell, Sarah J., Papagiannopoulos-Vatopaidinos, Ioannis-Eleemon, Papagiannopoulou, Maria, Pijl, Hanno, Ravussin, Eric, Ritzmann-Widderich, Martha, Varady, Krista, Adamidou, Lilian, Chihaoui, Melika, de Cabo, Rafael, Hassanein, Mohamed, Lessan, Nader, Longo, Valter, Manoogian, Emily N.C., Mattson, Mark P., Muhlestein, J. Brent, Panda, Satchidananda, Papadopoulou, Sousana K., Rodopaios, Nikolaos E., Stange, Rainer, and Michalsen, Andreas

Published
2024
Full Text
View/download PDF

3. Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

Author

Whelton, Paul, Johnson, Karen C., Snyder, Joni, Bild, Diane, Bonds, Denise, Cook, Nakela, Cutler, Jeffrey, Fine, Lawrence, Kaufmann, Peter, Kimmel, Paul, Launer, Lenore, Moy, Claudia, Riley, William, Ryan, Laurie, Tolunay, Eser, Yang, Song, Reboussin, David, Williamson, Jeff, Ambrosius, Walter T., Applegate, William, Evans, Greg, Foy, Capri, Freedman, Barry I., Kitzman, Dalane, Lyles, Mary, Pajewski, Nick, Rapp, Steve, Rushing, Scott, Shah, Neel, Sink, Kaycee M., Vitolins, Mara, Wagenknecht, Lynne, Wilson, Valerie, Perdue, Letitia, Woolard, Nancy, Craven, Tim, Garcia, Katelyn, Gaussoin, Sarah, Lovato, Laura, Newman, Jill, Lovato, James, Lu, Lingyi, McLouth, Chris, Russell, Greg, Amoroso, Bobby, Davis, Patty, Griffin, Jason, Harris, Darrin, King, Mark, Lane, Kathy, Roberson, Wes, Steinberg, Debbie, Ashford, Donna, Babcock, Phyllis, Chamberlain, Dana, Christensen, Vickie, Cloud, Loretta, Collins, Christy, Cook, Delilah, Currie, Katherine, Felton, Debbie, Harpe, Stacy, Howard, Marjorie, Lewis, Michelle, Nance, Pamela, Puccinelli-Ortega, Nicole, Russell, Laurie, Walker, Jennifer, Craven, Brenda, Goode, Candace, Troxler, Margie, Davis, Janet, Hutchens, Sarah, Killeen, Anthony A., Lukkari, Anna M., Ringer, Robert, Dillard, Brandi, Archibeque, Norbert, Warren, Stuart, Sather, Mike, Pontzer, James, Taylor, Zach, Soliman, Elsayed Z., Zhang, Zhu-Ming, Li, Yabing, Campbell, Chuck, Hensley, Susan, Hu, Julie, Keasler, Lisa, Barr, Mary, Taylor, Tonya, Bryan, R. Nick, Davatzikos, Christos, Nasarallah, Ilya, Desiderio, Lisa, Elliott, Mark, Borthakur, Ari, Battapady, Harsha, Erus, Guray, Smith, Alex, Wang, Ze, Doshi, Jimit, Wright, Jackson T., Jr., Rahman, Mahboob, Lerner, Alan J., Still, Carolyn, Wiggers, Alan, Zamanian, Sara, Bee, Alberta, Dancie, Renee, Thomas, George, Schreiber, Martin, Jr., Navaneethan, Sankar Dass, Hickner, John, Lioudis, Michael, Lard, Michelle, Marczewski, Susan, Maraschky, Jennifer, Colman, Martha, Aaby, Andrea, Payne, Stacey, Ramos, Melanie, Horner, Carol, Drawz, Paul, Raghavendra, Pratibha P., Ober, Scott, Mourad, Ronda, Pallaki, Muralidhar, Russo, Peter, Raghavendra, Pratibha, Fantauzzo, Pual, Tucker, Lisa, Schwing, Bill, Sedor, John R., Horwitz, Edward J., Schellling, Jeffrey R., O’Toole, John F., Humbert, Lisa, Tutolo, Wendy, White, Suzanne, Gay, Alishea, Clark, Walter, Jr., Hughes, Robin, Dobre, Mirela, Still, Carolyn H., Williams, Monique, Bhatt, Udayan, Hebert, Lee, Agarwal, Anil, Murphy, Melissa Brown, Ford, Nicole, Stratton, Cynthia, Baxter, Jody, Lykins, Alicia A., McKinley Neal Leena Hirmath, Alison, Kwame, Osei, Soe, Kyaw, Miser, William F., Sagrilla, Colleen, Johnston, Jan, Anaya, Amber, Mintos, Ashley, Howell, Angel A., Rogers, Kelly, Taylor, Sara, Ebersbacher, Donald, Long, Lucy, Bednarchik, Beth, Schnall, Adrian, Smith, Jonathan, Peysha, Lori, Leach, Lisa, Tribout, Megan, Harwell, Carla, Ellington, Pinkie, Banerji, Mary Ann, Ghody, Pranav, Rambaud, Melissa Vahídeh, Townsend, Raymond, Cohen, Debbie, Huan, Yonghong, Duckworth, Mark, Ford, Virginia, Leshner, Juliet, Davison, Ann, Veen, Sarah Vander, Gadegbeku, Crystal A., Gillespie, Avi, Paranjape, Anuradha, Amoroso, Sandra, Pfeffer, Zoe, Quinn, Sally B., He, Jiang, Chen, Jing, Lustigova, Eva, Malone, Erin, Krousel-Wood, Marie, Deichmann, Richard, Ronney, Patricia, Muery, Susan, Trapani, Donnalee, Rocco, Michael, Goff, David, Rodriguez, Carlos, Coker, Laura, Hawfield, Amret, Yeboah, Joseph, Crago, Lenore, Summerson, John, Hege, Anita, Diamond, Matt, Mulloy, Laura, Hodges, Marcela, Collins, Michelle, Weathers, Charlene, Anderson, Heather, Stone, Emily, Walker, Walida, McWilliams, Andrew, Dulin, Michael, Kuhn, Lindsay, Standridge, Susan, Lowe, Lindsay, Everett, Kelly, Preston, Kelry, Norton, Susan, Gaines, Silena, Rizvi, Ali A., Sides, Andrew W., Herbert, Diamond, Hix, Matthew M., Whitmire, Melanie, Arnold, Brittany, Hutchinson, Philip, Espiritu, Joseph, Feinglos, Mark, Kovalik, Eugene, Gedon-Lipscomb, Georgianne, Evans, Kathryn, Thacker, Connie, Zimmer, Ronna, Furst, Mary, Mason, MaryAnn, Powell, James, Bolin, Paul, Zhang, Junhong, Pinion, Mary, Davis, Gail, Bryant, Winifred, Phelps, Presley, Garris-Sutton, Connie, Atkinson, Beatrice, Contreras, Gabriele, Suarez, Maritza, Schulman, Ivonne, Koggan, Don, Vassallo, Jackie, Peruyera, Gloria, Whittington, Sheri, Bethea, Cassandra, Gilliam, Laura, Pedley, Carolyn, Zurek, Geraldine, Baird, Miriam, Herring, Charles, Smoak, Mary Martha, Williams, Julie, Rogers, Samantha, Gordon, Lindsay, Kennedy, Erin, Belle, Beverly, McCorkle-Doomy, Jessica, Adams, Jonathan, Lopez, Ramon, Janavs, Juris, Rahbari-Oskoui, Frederic, Chapman, Arlene, Dollar, Allen, Williams, Olubunmi, Han, Yoosun, Haley, William, Fitzpatrick, Peter, Blackshear, Joseph, Shapiro, Brian, Harrell, Anna, Palaj, Arta, Henderson, Katelyn, Johnson, Ashley, Gonzalez, Heath, Robinson, Jermaine, Tamariz, Leonardo, Denizard, Jennifer, Barakat, Rody, Krishnamoorthy, Dhurga, Greenway, Frank, Monce, Ron, Church, Timothy, Hendrick, Chelsea, Yoches, Aimee, Sones, Leighanne, Baltazar, Markee, Pemu, Priscilla, Jones, Connie, Akpalu, Derrick, Cheung, Alfred K., Beddhu, Srinivasan, Chelune, Gordon, Childs, Jeffrey, Gren, Lisa, Randall, Anne, Dember, Laura, Soares, Denise, Yee, Jerry, Umanath, Kausik, Ogletree, Naima, Thaxton, Schawana, Campana, Karen, Sheldon, Dayna, MacArthur, Krista, Muhlestein, J. Brent, Allred, Nathan, Clements, Brian, Dhar, Ritesh, Meredith, Kent, Le, Viet, Miner, Edward, Orford, James, Riessen, Erik R., Ballantyne, Becca, Chisum, Ben, Johnson, Kevin, Peeler, Dixie, Chertow, Glenn, Tamura, Manju, Chang, Tara, Erickson, Kevin, Shen, Jenny, Stafford, Randall S., Zaharchuk, Gregory, Del Cid, Margareth, Dentinger, Michelle, Sabino, Jennifer, Sahay, Rukmani, Telminova, Ekaterina, Weiner, Daniel E., Sarnak, Mark, Chan, Lily, Civiletto, Amanda, Heath, Alyson, Kantor, Amy, Jain, Priyanka, Kirkpatrick, Bethany, Well, Andrew, Yuen, Barry, Chonchol, Michel, Farmer, Beverly, Farmer, Heather, Greenwald, Carol, Malaczewski, Mikaela, Lash, James, Porter, Anna, Ricardo, Ana, Rosman, Robert T., Cohan, Janet, Barrera, Nieves Lopez, Meslar, Daniel, Meslar, Patricia, Conroy, Margaret, Unruh, Mark, Hess, Rachel, Jhamb, Manisha, Thomas, Holly, Fazio, Pam, Klixbull, Elle, Komlos-Weimer, Melissa, Mandich, LeeAnne, Vita, Tina, Toto, Robert, Van Buren, Peter, Inrig, Julia, Cruz, Martha, Lightfoot, Tammy, Wang, Nancy, Webster, Lori, Raphael, Kalani, Stults, Barry, Zaman, Tahir, Simmons, Debra, Lavasani, Tooran, Filipowicz, Rebecca, Wei, Guo, Miller, Gracie Mary, Harerra, Jenice, Christensen, Jeff, Giri, Ajay, Chen, Xiaorui, Anderton, Natalie, Jensen, Arianna, Lewis, Julia, Burgner, Anna, Dwyer, Jamie P., Schulman, Gerald, Herrud, Terri, Leavell, Ewanda, McCray, Tiffany, McNeil-Simaan, Edwina, Poudel, Munmun, Reed, Malia, Sika, Mohammed, Woods, Delia, Zirkenbach, Janice L., Raj, Dominic S., Cohen, Scott, Patel, Samir, Velasquez, Manuel, Bastian, Roshni S., Wing, Maria, Roy-Chaudhury, Akshay, Depner, Thomas, Dalyrymple, Lorien, Kaysen, George, Anderson, Susan, Nord, John, Ix, Joachim H., Goldenstein, Leonard, Miracle, Cynthia M., Forbang, Nketi, Mircic, Maja, Thomas, Brenda, Tran, Tiffany, Rastogi, Anjay, Kim, Mihae, Rashid, Mohamad, Lizarraga, Bianca, Hocza, Amy, Sarmosyan, Kristine, Norris, Jason, Sharma, Tushar, Chioy, Amanda, Bernard, Eric, Cabrera, Eleanore, Lopez, Christina, Nunez, Susana, Riad, Joseph, Schweitzer, Suzanne, Sirop, Siran, Thomas, Sarah, Wada, Lauren, Kramer, Holly, Bansal, Vinod, Taylor, Corliss E., Segal, Mark S., Hall, Karen L., Kazory, Amir, Gilbert, Lesa, Owens, Linda, Poulton, Danielle, Whidden, Elaine, Wiggins, Jocelyn, Blaum, Caroline, Nyquist, Linda, Min, Lillian, Gure, Tanya, Lewis, Ruth, Mawby, Jennifer, Robinson, Eileen, Oparil, Suzanne, Lewis, Cora E., Bradley, Virginia, Calhoun, David, Glasser, Stephen, Jenkins, Kim, Ramsey, Tom, Qureshi, Nauman, Ferguson, Karen, Haider, Sumrah, James, Mandy, Jones, Christy, Renfroe, Kim, Seay, April, Weigart, Carrie, Thornley-Brown, Denyse, Rizik, Dana, Cotton, Bari, Fitz-Gerald, Meredith, Grimes, Tiffany, Johnson, Carolyn, Kennedy, Sara, Mason, Chanel, Rosato-Burson, Lesa, Willingham, Robin, Judd, Eric, Breaux-Shropshire, Tonya, Cook, Felice, Medina, Julia, Ghazi, Lama, Bhatt, Hemal, Lewis, James, Brantley, Roman, Brouilette, John, Glaze, Jeffrey, Hall, Stephanie, Hiott, Nancy, Tharpe, David, Boddy, Spencer, Mack, Catherine, Womack, Catherine, Asao, Keiko, Griffin, Beate, Hendrix, Carol, Johnson, Karen, Jones, Lisa, Towers, Chelsea, Punzi, Henry, Cassidy, Kathy, Schumacher, Kristin, Irizarry, Carmen, Colon, Ilma, Colon-Ortiz, Pedro, Colón-Hernández, Pedro J., Carrasquillo-Navarro, Orlando J., Carrasquillo, Merari, Vazquez, Nivea, Sosa-Padilla, Miguel, Cintron-Pinero, Alex, Ayala, Mayra, Pacheco, Olga, Rivera, Catalina, Sotomayor-Gonzalez, Irma, Claudio, Jamie, Lazaro, Jose, Arce, Migdalia, Heres, Lourdes, Perez, Alba, Tavarez-Valle, Jose, Arocho, Ferlinda, Torres, Mercedes, Vazquez, Melvaliz, Aurigemma, Gerard P., Takis-Smith, Rebecca, Andrieni, Julia, Bodkin, Noelle, Chaudhary, Kiran, Hu, Paula, Kostis, John, Cosgrove, Nora, Bankowski, Denise, Boleyn, Monica, Casazza, Laurie, Giresi, Victoria, Patel, Tosha, Squindo, Erin, Wu, Yan, Henson, Zeb, Wofford, Marion, Lowery, Jessica, Minor, Deborah, Harkins, Kimberley, Auchus, Alexander, Flessner, Michael, Adair, Cathy, Asher, Jordan, Loope, Debbie, Cobb, Rita, Venegas, Reiner, Bigger, Thomas, Bello, Natalie, Homma, Shunichi, Donovan, Daniel, Lopez-Jimenez, Carlos, Tirado, Amilcar, Getaneh, Asqual, Tang, Rocky, Durant, Sabrina, Maurer, Mathew, Teruya, Sergio, Helmke, Stephen, Alvarez, Julissa, Campbell, Ruth, Pisoni, Roberto, Sturdivant, Rachel, Brooks, Deborah, Counts, Caroline, Hunt, Vickie, Spillers, Lori, Brautigam, Donald, Kitchen, Timothy, Gorman, Timothy, Sayers, Jessica, Button, Sarah, Chiarot, June, Fischer, Rosemary, Lyon, Melissa, Resnick, Maria, Hodges, Nicole, Ferreira, Jennifer, Cushman, William, Wall, Barry, Nichols, Linda, Burns, Robert, Martindale-Adams, Jennifer, Berlowitz, Dan, Clark, Elizabeth, Walsh, Sandy, Geraci, Terry, Huff, Carol, Shaw, Linda, Servilla, Karen, Vigil, Darlene, Barrett, Terry, Sweeney, Mary Ellen, Johnson, Rebecca, McConnell, Susan, Salles, Khadijeh Shahid, Watson, Francoise, Schenk, Cheryl, Whittington, Laura, Maher, Maxine, Williams, Jonathan, Swartz, Stephen, Conlin, Paul, Alexis, George, Lamkin, Rebecca, Underwood, Patti, Gomes, Helen, Rosendorff, Clive, Atlas, Stephen, Khan, Saadat, Gonzalez, Waddy, Barcham, Samih, Kwon, Lawrence, Matar, Matar, Adhami, Anwar, Basile, Jan, John, Joseph, Ham, Deborah, Baig, Hadi, Saklayen, Mohammed, Yap, Jason, Neff, Helen, Miller, Carol, Zheng-Phelan, Ling, Gappy, Saib, Rau, Shiva, Raman, Arathi, Berchou, Vicki, Jones, Elizabeth, Olgren, Erin, Marbury, Cynthia, Yudd, Michael, Sastrasinh, Sithiporn, Michaud, Jennine, Fiore, Jessica, Kutza, Marianne, Shorr, Ronald, Mount, Rattana, Dunn, Helen, Stinson, Susan, Hunter, Jessica, Taylor, Addison, Bates, Jeffery, Anderson, Catherine, Kirchner, Kent, Stubbs, Jodi, Hinton, Ardell, Spencer, Anita, Sharma, Santosh, Wiegmann, Thomas, Mehta, Smita, Krause, Michelle, Dishongh, Kate, Childress, Richard, Gyamlani, Geeta, Niakan, Atossa, Thompson, Cathy, Moody, Janelle, Gresham, Carolyn, Whittle, Jeffrey, Barnas, Gary, Wolfgram, Dawn, Cortese, Heidi, Johnson, Jonette, Roumie, Christianne, Hung, Adriana, Wharton, Jennifer, Niesner, Kurt, Katz, Lois, Richardson, Elizabeth, Brock, George, Holland, Joanne, Dixon, Troy, Zias, Athena, Spiller, Christine, Baker, Penelope, Felicetta, James, Rehman, Shakaib, Bingham, Kelli, Watnick, Suzanne, Cohen, David, Weiss, Jessica, Johnston, Tera, Giddings, Stephen, Yamout, Hala, Klein, Andrew, Rowe, Caroline, Vargo, Kristin, Waidmann, Kristi, Papademetriou, Vasilios, Elkhoury, Jean Pierre, Gregory, Barbara, Amodeo, Susan, Bloom, Mary, Goldfarb-Waysman, Dalia, Treger, Richard, Kashefi, Mehran, Huang, Christina, Knibloe, Karen, Ishani, Areef, Slinin, Yelena, Olney, Christine, Rust, Jacqueline, Fanti, Paolo, Dyer, Christopher, Bansal, Shweta, Dunnam, Monica, Hu, Lih-Lan, Zarate-Abbott, Perla, Kurella Tamura, Manjula, Pajewski, Nicholas M., Zaharchuk, Greg, Rapp, Stephen R., Auchus, Alexander P., Haley, William E., Kendrick, Jessica, Roumie, Christianne L., Williamson, Jeff D., Detre, John A., Dolui, Sudipto, and Nasrallah, Ilya M.

Published
2022
Full Text
View/download PDF

4. Effect of Vascepa (icosapent ethyl) on progression of coronary atherosclerosis in patients with elevated triglycerides (200-499 mg/dL) on statin therapy: Rationale and design of the EVAPORATE study.

Author

Budoff, Matthew, Brent Muhlestein, J, Le, Viet T, May, Heidi T, Roy, Sion, and Nelson, John R

Subjects
Humans, Hypertriglyceridemia, Disease Progression, Eicosapentaenoic Acid, Triglycerides, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Treatment Outcome, Drug Therapy, Combination, Risk Factors, Follow-Up Studies, Double-Blind Method, Dose-Response Relationship, Drug, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Atherosclerosis, Coronary Artery Disease, Hypolipidemic Agents, Biomarkers, Atherosclerotic Plaque, Cardiovascular Imaging Techniques, Icosapent Ethyl, and over, Dose-Response Relationship, Drug, Drug Therapy, Combination, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

Despite reducing progression and promoting regression of coronary atherosclerosis, statin therapy does not fully address residual cardiovascular (CV) risk. High-purity eicosapentaenoic acid (EPA) added to a statin has been shown to reduce CV events and induce regression of coronary atherosclerosis in imaging studies; however, data are from Japanese populations without high triglyceride (TG) levels and baseline EPA serum levels greater than those in North American populations. Icosapent ethyl is a high-purity prescription EPA ethyl ester approved at 4 g/d as an adjunct to diet to reduce TG levels in adults with TG levels >499 mg/dL. The objective of the randomized, double-blind, placebo-controlled EVAPORATE study is to evaluate the effects of icosapent ethyl 4 g/d on atherosclerotic plaque in a North American population of statin-treated patients with coronary atherosclerosis, TG levels of 200 to 499 mg/dL, and low-density lipoprotein cholesterol levels of 40 to 115 mg/dL. The primary endpoint is change in low-attenuation plaque volume measured by multidetector computed tomography angiography. Secondary endpoints include incident plaque rates; quantitative changes in different plaque types and morphology; changes in markers of inflammation, lipids, and lipoproteins; and the relationship between these changes and plaque burden and/or plaque vulnerability. Approximately 80 patients will be followed for 9 to 18 months. The clinical implications of icosapent ethyl 4 g/d treatment added to statin therapy on CV endpoints are being evaluated in the large CV outcomes study REDUCE-IT. EVAPORATE will provide important imaging-derived data that may add relevance to the clinically derived outcomes from REDUCE-IT.

Published
2018

5. Primary Prevention Trial Designs Using Coronary Imaging: A National Heart, Lung, and Blood Institute Workshop

Author

Greenland, Philip, Michos, Erin D., Redmond, Nicole, Fine, Lawrence J., Alexander, Karen P., Ambrosius, Walter T., Bibbins-Domingo, Kirsten, Blaha, Michael J., Blankstein, Ron, Fortmann, Stephen P., Khera, Amit, Lloyd-Jones, Donald M., Maron, David J., Min, James K., Muhlestein, J. Brent, Nasir, Khurram, Sterling, Madeline R., and Thanassoulis, George

Published
2021
Full Text
View/download PDF

6. The history and geographic distribution of a KCNQ1 atrial fibrillation risk allele

Author

Hateley, Shannon, Lopez-Izquierdo, Angelica, Jou, Chuanchau J., Cho, Scott, Schraiber, Joshua G., Song, Shiya, Maguire, Colin T., Torres, Natalia, Riedel, Michael, Bowles, Neil E., Arrington, Cammon B., Kennedy, Brett J., Etheridge, Susan P., Lai, Shuping, Pribble, Chase, Meyers, Lindsay, Lundahl, Derek, Byrnes, Jake, Granka, Julie M., Kauffman, Christopher A., Lemmon, Gordon, Boyden, Steven, Scott Watkins, W., Karren, Mary Anne, Knight, Stacey, Brent Muhlestein, J., Carlquist, John F., Anderson, Jeffrey L., Chahine, Kenneth G., Shah, Khushi U., Ball, Catherine A., Benjamin, Ivor J., Yandell, Mark, and Tristani-Firouzi, Martin

Published
2021
Full Text
View/download PDF

7. Use of prasugrel vs clopidogrel and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention in contemporary clinical practice: Results from the PROMETHEUS study

Author

Baber, Usman, Sartori, Samantha, Aquino, Melissa, Kini, Annapoorna, Kapadia, Samir, Weiss, Sandra, Strauss, Craig, Muhlestein, J. Brent, Toma, Catalin, Rao, Sunil V., DeFranco, Anthony, Poddar, Kanhaiya L., Chandrasekhar, Jaya, Weintraub, William, Henry, Timothy D., Bansilal, Sameer, Baker, Brian A., Marrett, Elizabeth, Keller, Stuart, Effron, Mark, Pocock, Stuart, and Mehran, Roxana

Published
2017
Full Text
View/download PDF

16. Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

Author

Kurella Tamura, Manjula, primary, Gaussoin, Sarah, additional, Pajewski, Nicholas M., additional, Zaharchuk, Greg, additional, Freedman, Barry I., additional, Rapp, Stephen R., additional, Auchus, Alexander P., additional, Haley, William E., additional, Oparil, Suzanne, additional, Kendrick, Jessica, additional, Roumie, Christianne L., additional, Beddhu, Srinivasan, additional, Cheung, Alfred K., additional, Williamson, Jeff D., additional, Detre, John A., additional, Dolui, Sudipto, additional, Bryan, R. Nick, additional, Nasrallah, Ilya M., additional, Whelton, Paul, additional, Johnson, Karen C., additional, Snyder, Joni, additional, Bild, Diane, additional, Bonds, Denise, additional, Cook, Nakela, additional, Cutler, Jeffrey, additional, Fine, Lawrence, additional, Kaufmann, Peter, additional, Kimmel, Paul, additional, Launer, Lenore, additional, Moy, Claudia, additional, Riley, William, additional, Ryan, Laurie, additional, Tolunay, Eser, additional, Yang, Song, additional, Reboussin, David, additional, Williamson, Jeff, additional, Ambrosius, Walter T., additional, Applegate, William, additional, Evans, Greg, additional, Foy, Capri, additional, Kitzman, Dalane, additional, Lyles, Mary, additional, Pajewski, Nick, additional, Rapp, Steve, additional, Rushing, Scott, additional, Shah, Neel, additional, Sink, Kaycee M., additional, Vitolins, Mara, additional, Wagenknecht, Lynne, additional, Wilson, Valerie, additional, Perdue, Letitia, additional, Woolard, Nancy, additional, Craven, Tim, additional, Garcia, Katelyn, additional, Lovato, Laura, additional, Newman, Jill, additional, Lovato, James, additional, Lu, Lingyi, additional, McLouth, Chris, additional, Russell, Greg, additional, Amoroso, Bobby, additional, Davis, Patty, additional, Griffin, Jason, additional, Harris, Darrin, additional, King, Mark, additional, Lane, Kathy, additional, Roberson, Wes, additional, Steinberg, Debbie, additional, Ashford, Donna, additional, Babcock, Phyllis, additional, Chamberlain, Dana, additional, Christensen, Vickie, additional, Cloud, Loretta, additional, Collins, Christy, additional, Cook, Delilah, additional, Currie, Katherine, additional, Felton, Debbie, additional, Harpe, Stacy, additional, Howard, Marjorie, additional, Lewis, Michelle, additional, Nance, Pamela, additional, Puccinelli-Ortega, Nicole, additional, Russell, Laurie, additional, Walker, Jennifer, additional, Craven, Brenda, additional, Goode, Candace, additional, Troxler, Margie, additional, Davis, Janet, additional, Hutchens, Sarah, additional, Killeen, Anthony A., additional, Lukkari, Anna M., additional, Ringer, Robert, additional, Dillard, Brandi, additional, Archibeque, Norbert, additional, Warren, Stuart, additional, Sather, Mike, additional, Pontzer, James, additional, Taylor, Zach, additional, Soliman, Elsayed Z., additional, Zhang, Zhu-Ming, additional, Li, Yabing, additional, Campbell, Chuck, additional, Hensley, Susan, additional, Hu, Julie, additional, Keasler, Lisa, additional, Barr, Mary, additional, Taylor, Tonya, additional, Davatzikos, Christos, additional, Nasarallah, Ilya, additional, Desiderio, Lisa, additional, Elliott, Mark, additional, Borthakur, Ari, additional, Battapady, Harsha, additional, Erus, Guray, additional, Smith, Alex, additional, Wang, Ze, additional, Doshi, Jimit, additional, Wright, Jackson T., additional, Rahman, Mahboob, additional, Lerner, Alan J., additional, Still, Carolyn, additional, Wiggers, Alan, additional, Zamanian, Sara, additional, Bee, Alberta, additional, Dancie, Renee, additional, Thomas, George, additional, Schreiber, Martin, additional, Navaneethan, Sankar Dass, additional, Hickner, John, additional, Lioudis, Michael, additional, Lard, Michelle, additional, Marczewski, Susan, additional, Maraschky, Jennifer, additional, Colman, Martha, additional, Aaby, Andrea, additional, Payne, Stacey, additional, Ramos, Melanie, additional, Horner, Carol, additional, Drawz, Paul, additional, Raghavendra, Pratibha P., additional, Ober, Scott, additional, Mourad, Ronda, additional, Pallaki, Muralidhar, additional, Russo, Peter, additional, Raghavendra, Pratibha, additional, Fantauzzo, Pual, additional, Tucker, Lisa, additional, Schwing, Bill, additional, Sedor, John R., additional, Horwitz, Edward J., additional, Schellling, Jeffrey R., additional, O’Toole, John F., additional, Humbert, Lisa, additional, Tutolo, Wendy, additional, White, Suzanne, additional, Gay, Alishea, additional, Clark, Walter, additional, Hughes, Robin, additional, Dobre, Mirela, additional, Still, Carolyn H., additional, Williams, Monique, additional, Bhatt, Udayan, additional, Hebert, Lee, additional, Agarwal, Anil, additional, Murphy, Melissa Brown, additional, Ford, Nicole, additional, Stratton, Cynthia, additional, Baxter, Jody, additional, Lykins, Alicia A., additional, McKinley Neal Leena Hirmath, Alison, additional, Kwame, Osei, additional, Soe, Kyaw, additional, Miser, William F., additional, Sagrilla, Colleen, additional, Johnston, Jan, additional, Anaya, Amber, additional, Mintos, Ashley, additional, Howell, Angel A., additional, Rogers, Kelly, additional, Taylor, Sara, additional, Ebersbacher, Donald, additional, Long, Lucy, additional, Bednarchik, Beth, additional, Schnall, Adrian, additional, Smith, Jonathan, additional, Peysha, Lori, additional, Leach, Lisa, additional, Tribout, Megan, additional, Harwell, Carla, additional, Ellington, Pinkie, additional, Banerji, Mary Ann, additional, Ghody, Pranav, additional, Rambaud, Melissa Vahídeh, additional, Townsend, Raymond, additional, Cohen, Debbie, additional, Huan, Yonghong, additional, Duckworth, Mark, additional, Ford, Virginia, additional, Leshner, Juliet, additional, Davison, Ann, additional, Veen, Sarah Vander, additional, Gadegbeku, Crystal A., additional, Gillespie, Avi, additional, Paranjape, Anuradha, additional, Amoroso, Sandra, additional, Pfeffer, Zoe, additional, Quinn, Sally B., additional, He, Jiang, additional, Chen, Jing, additional, Lustigova, Eva, additional, Malone, Erin, additional, Krousel-Wood, Marie, additional, Deichmann, Richard, additional, Ronney, Patricia, additional, Muery, Susan, additional, Trapani, Donnalee, additional, Rocco, Michael, additional, Goff, David, additional, Rodriguez, Carlos, additional, Coker, Laura, additional, Hawfield, Amret, additional, Yeboah, Joseph, additional, Crago, Lenore, additional, Summerson, John, additional, Hege, Anita, additional, Diamond, Matt, additional, Mulloy, Laura, additional, Hodges, Marcela, additional, Collins, Michelle, additional, Weathers, Charlene, additional, Anderson, Heather, additional, Stone, Emily, additional, Walker, Walida, additional, McWilliams, Andrew, additional, Dulin, Michael, additional, Kuhn, Lindsay, additional, Standridge, Susan, additional, Lowe, Lindsay, additional, Everett, Kelly, additional, Preston, Kelry, additional, Norton, Susan, additional, Gaines, Silena, additional, Rizvi, Ali A., additional, Sides, Andrew W., additional, Herbert, Diamond, additional, Hix, Matthew M., additional, Whitmire, Melanie, additional, Arnold, Brittany, additional, Hutchinson, Philip, additional, Espiritu, Joseph, additional, Feinglos, Mark, additional, Kovalik, Eugene, additional, Gedon-Lipscomb, Georgianne, additional, Evans, Kathryn, additional, Thacker, Connie, additional, Zimmer, Ronna, additional, Furst, Mary, additional, Mason, MaryAnn, additional, Powell, James, additional, Bolin, Paul, additional, Zhang, Junhong, additional, Pinion, Mary, additional, Davis, Gail, additional, Bryant, Winifred, additional, Phelps, Presley, additional, Garris-Sutton, Connie, additional, Atkinson, Beatrice, additional, Contreras, Gabriele, additional, Suarez, Maritza, additional, Schulman, Ivonne, additional, Koggan, Don, additional, Vassallo, Jackie, additional, Peruyera, Gloria, additional, Whittington, Sheri, additional, Bethea, Cassandra, additional, Gilliam, Laura, additional, Pedley, Carolyn, additional, Zurek, Geraldine, additional, Baird, Miriam, additional, Herring, Charles, additional, Smoak, Mary Martha, additional, Williams, Julie, additional, Rogers, Samantha, additional, Gordon, Lindsay, additional, Kennedy, Erin, additional, Belle, Beverly, additional, McCorkle-Doomy, Jessica, additional, Adams, Jonathan, additional, Lopez, Ramon, additional, Janavs, Juris, additional, Rahbari-Oskoui, Frederic, additional, Chapman, Arlene, additional, Dollar, Allen, additional, Williams, Olubunmi, additional, Han, Yoosun, additional, Haley, William, additional, Fitzpatrick, Peter, additional, Blackshear, Joseph, additional, Shapiro, Brian, additional, Harrell, Anna, additional, Palaj, Arta, additional, Henderson, Katelyn, additional, Johnson, Ashley, additional, Gonzalez, Heath, additional, Robinson, Jermaine, additional, Tamariz, Leonardo, additional, Denizard, Jennifer, additional, Barakat, Rody, additional, Krishnamoorthy, Dhurga, additional, Greenway, Frank, additional, Monce, Ron, additional, Church, Timothy, additional, Hendrick, Chelsea, additional, Yoches, Aimee, additional, Sones, Leighanne, additional, Baltazar, Markee, additional, Pemu, Priscilla, additional, Jones, Connie, additional, Akpalu, Derrick, additional, Chelune, Gordon, additional, Childs, Jeffrey, additional, Gren, Lisa, additional, Randall, Anne, additional, Dember, Laura, additional, Soares, Denise, additional, Yee, Jerry, additional, Umanath, Kausik, additional, Ogletree, Naima, additional, Thaxton, Schawana, additional, Campana, Karen, additional, Sheldon, Dayna, additional, MacArthur, Krista, additional, Muhlestein, J. Brent, additional, Allred, Nathan, additional, Clements, Brian, additional, Dhar, Ritesh, additional, Meredith, Kent, additional, Le, Viet, additional, Miner, Edward, additional, Orford, James, additional, Riessen, Erik R., additional, Ballantyne, Becca, additional, Chisum, Ben, additional, Johnson, Kevin, additional, Peeler, Dixie, additional, Chertow, Glenn, additional, Tamura, Manju, additional, Chang, Tara, additional, Erickson, Kevin, additional, Shen, Jenny, additional, Stafford, Randall S., additional, Zaharchuk, Gregory, additional, Del Cid, Margareth, additional, Dentinger, Michelle, additional, Sabino, Jennifer, additional, Sahay, Rukmani, additional, Telminova, Ekaterina, additional, Weiner, Daniel E., additional, Sarnak, Mark, additional, Chan, Lily, additional, Civiletto, Amanda, additional, Heath, Alyson, additional, Kantor, Amy, additional, Jain, Priyanka, additional, Kirkpatrick, Bethany, additional, Well, Andrew, additional, Yuen, Barry, additional, Chonchol, Michel, additional, Farmer, Beverly, additional, Farmer, Heather, additional, Greenwald, Carol, additional, Malaczewski, Mikaela, additional, Lash, James, additional, Porter, Anna, additional, Ricardo, Ana, additional, Rosman, Robert T., additional, Cohan, Janet, additional, Barrera, Nieves Lopez, additional, Meslar, Daniel, additional, Meslar, Patricia, additional, Conroy, Margaret, additional, Unruh, Mark, additional, Hess, Rachel, additional, Jhamb, Manisha, additional, Thomas, Holly, additional, Fazio, Pam, additional, Klixbull, Elle, additional, Komlos-Weimer, Melissa, additional, Mandich, LeeAnne, additional, Vita, Tina, additional, Toto, Robert, additional, Van Buren, Peter, additional, Inrig, Julia, additional, Cruz, Martha, additional, Lightfoot, Tammy, additional, Wang, Nancy, additional, Webster, Lori, additional, Raphael, Kalani, additional, Stults, Barry, additional, Zaman, Tahir, additional, Simmons, Debra, additional, Lavasani, Tooran, additional, Filipowicz, Rebecca, additional, Wei, Guo, additional, Miller, Gracie Mary, additional, Harerra, Jenice, additional, Christensen, Jeff, additional, Giri, Ajay, additional, Chen, Xiaorui, additional, Anderton, Natalie, additional, Jensen, Arianna, additional, Lewis, Julia, additional, Burgner, Anna, additional, Dwyer, Jamie P., additional, Schulman, Gerald, additional, Herrud, Terri, additional, Leavell, Ewanda, additional, McCray, Tiffany, additional, McNeil-Simaan, Edwina, additional, Poudel, Munmun, additional, Reed, Malia, additional, Sika, Mohammed, additional, Woods, Delia, additional, Zirkenbach, Janice L., additional, Raj, Dominic S., additional, Cohen, Scott, additional, Patel, Samir, additional, Velasquez, Manuel, additional, Bastian, Roshni S., additional, Wing, Maria, additional, Roy-Chaudhury, Akshay, additional, Depner, Thomas, additional, Dalyrymple, Lorien, additional, Kaysen, George, additional, Anderson, Susan, additional, Nord, John, additional, Ix, Joachim H., additional, Goldenstein, Leonard, additional, Miracle, Cynthia M., additional, Forbang, Nketi, additional, Mircic, Maja, additional, Thomas, Brenda, additional, Tran, Tiffany, additional, Rastogi, Anjay, additional, Kim, Mihae, additional, Rashid, Mohamad, additional, Lizarraga, Bianca, additional, Hocza, Amy, additional, Sarmosyan, Kristine, additional, Norris, Jason, additional, Sharma, Tushar, additional, Chioy, Amanda, additional, Bernard, Eric, additional, Cabrera, Eleanore, additional, Lopez, Christina, additional, Nunez, Susana, additional, Riad, Joseph, additional, Schweitzer, Suzanne, additional, Sirop, Siran, additional, Thomas, Sarah, additional, Wada, Lauren, additional, Kramer, Holly, additional, Bansal, Vinod, additional, Taylor, Corliss E., additional, Segal, Mark S., additional, Hall, Karen L., additional, Kazory, Amir, additional, Gilbert, Lesa, additional, Owens, Linda, additional, Poulton, Danielle, additional, Whidden, Elaine, additional, Wiggins, Jocelyn, additional, Blaum, Caroline, additional, Nyquist, Linda, additional, Min, Lillian, additional, Gure, Tanya, additional, Lewis, Ruth, additional, Mawby, Jennifer, additional, Robinson, Eileen, additional, Lewis, Cora E., additional, Bradley, Virginia, additional, Calhoun, David, additional, Glasser, Stephen, additional, Jenkins, Kim, additional, Ramsey, Tom, additional, Qureshi, Nauman, additional, Ferguson, Karen, additional, Haider, Sumrah, additional, James, Mandy, additional, Jones, Christy, additional, Renfroe, Kim, additional, Seay, April, additional, Weigart, Carrie, additional, Thornley-Brown, Denyse, additional, Rizik, Dana, additional, Cotton, Bari, additional, Fitz-Gerald, Meredith, additional, Grimes, Tiffany, additional, Johnson, Carolyn, additional, Kennedy, Sara, additional, Mason, Chanel, additional, Rosato-Burson, Lesa, additional, Willingham, Robin, additional, Judd, Eric, additional, Breaux-Shropshire, Tonya, additional, Cook, Felice, additional, Medina, Julia, additional, Ghazi, Lama, additional, Bhatt, Hemal, additional, Lewis, James, additional, Brantley, Roman, additional, Brouilette, John, additional, Glaze, Jeffrey, additional, Hall, Stephanie, additional, Hiott, Nancy, additional, Tharpe, David, additional, Boddy, Spencer, additional, Mack, Catherine, additional, Womack, Catherine, additional, Asao, Keiko, additional, Griffin, Beate, additional, Hendrix, Carol, additional, Johnson, Karen, additional, Jones, Lisa, additional, Towers, Chelsea, additional, Punzi, Henry, additional, Cassidy, Kathy, additional, Schumacher, Kristin, additional, Irizarry, Carmen, additional, Colon, Ilma, additional, Colon-Ortiz, Pedro, additional, Colón-Hernández, Pedro J., additional, Carrasquillo-Navarro, Orlando J., additional, Carrasquillo, Merari, additional, Vazquez, Nivea, additional, Sosa-Padilla, Miguel, additional, Cintron-Pinero, Alex, additional, Ayala, Mayra, additional, Pacheco, Olga, additional, Rivera, Catalina, additional, Sotomayor-Gonzalez, Irma, additional, Claudio, Jamie, additional, Lazaro, Jose, additional, Arce, Migdalia, additional, Heres, Lourdes, additional, Perez, Alba, additional, Tavarez-Valle, Jose, additional, Arocho, Ferlinda, additional, Torres, Mercedes, additional, Vazquez, Melvaliz, additional, Aurigemma, Gerard P., additional, Takis-Smith, Rebecca, additional, Andrieni, Julia, additional, Bodkin, Noelle, additional, Chaudhary, Kiran, additional, Hu, Paula, additional, Kostis, John, additional, Cosgrove, Nora, additional, Bankowski, Denise, additional, Boleyn, Monica, additional, Casazza, Laurie, additional, Giresi, Victoria, additional, Patel, Tosha, additional, Squindo, Erin, additional, Wu, Yan, additional, Henson, Zeb, additional, Wofford, Marion, additional, Lowery, Jessica, additional, Minor, Deborah, additional, Harkins, Kimberley, additional, Auchus, Alexander, additional, Flessner, Michael, additional, Adair, Cathy, additional, Asher, Jordan, additional, Loope, Debbie, additional, Cobb, Rita, additional, Venegas, Reiner, additional, Bigger, Thomas, additional, Bello, Natalie, additional, Homma, Shunichi, additional, Donovan, Daniel, additional, Lopez-Jimenez, Carlos, additional, Tirado, Amilcar, additional, Getaneh, Asqual, additional, Tang, Rocky, additional, Durant, Sabrina, additional, Maurer, Mathew, additional, Teruya, Sergio, additional, Helmke, Stephen, additional, Alvarez, Julissa, additional, Campbell, Ruth, additional, Pisoni, Roberto, additional, Sturdivant, Rachel, additional, Brooks, Deborah, additional, Counts, Caroline, additional, Hunt, Vickie, additional, Spillers, Lori, additional, Brautigam, Donald, additional, Kitchen, Timothy, additional, Gorman, Timothy, additional, Sayers, Jessica, additional, Button, Sarah, additional, Chiarot, June, additional, Fischer, Rosemary, additional, Lyon, Melissa, additional, Resnick, Maria, additional, Hodges, Nicole, additional, Ferreira, Jennifer, additional, Cushman, William, additional, Wall, Barry, additional, Nichols, Linda, additional, Burns, Robert, additional, Martindale-Adams, Jennifer, additional, Berlowitz, Dan, additional, Clark, Elizabeth, additional, Walsh, Sandy, additional, Geraci, Terry, additional, Huff, Carol, additional, Shaw, Linda, additional, Servilla, Karen, additional, Vigil, Darlene, additional, Barrett, Terry, additional, Sweeney, Mary Ellen, additional, Johnson, Rebecca, additional, McConnell, Susan, additional, Salles, Khadijeh Shahid, additional, Watson, Francoise, additional, Schenk, Cheryl, additional, Whittington, Laura, additional, Maher, Maxine, additional, Williams, Jonathan, additional, Swartz, Stephen, additional, Conlin, Paul, additional, Alexis, George, additional, Lamkin, Rebecca, additional, Underwood, Patti, additional, Gomes, Helen, additional, Rosendorff, Clive, additional, Atlas, Stephen, additional, Khan, Saadat, additional, Gonzalez, Waddy, additional, Barcham, Samih, additional, Kwon, Lawrence, additional, Matar, Matar, additional, Adhami, Anwar, additional, Basile, Jan, additional, John, Joseph, additional, Ham, Deborah, additional, Baig, Hadi, additional, Saklayen, Mohammed, additional, Yap, Jason, additional, Neff, Helen, additional, Miller, Carol, additional, Zheng-Phelan, Ling, additional, Gappy, Saib, additional, Rau, Shiva, additional, Raman, Arathi, additional, Berchou, Vicki, additional, Jones, Elizabeth, additional, Olgren, Erin, additional, Marbury, Cynthia, additional, Yudd, Michael, additional, Sastrasinh, Sithiporn, additional, Michaud, Jennine, additional, Fiore, Jessica, additional, Kutza, Marianne, additional, Shorr, Ronald, additional, Mount, Rattana, additional, Dunn, Helen, additional, Stinson, Susan, additional, Hunter, Jessica, additional, Taylor, Addison, additional, Bates, Jeffery, additional, Anderson, Catherine, additional, Kirchner, Kent, additional, Stubbs, Jodi, additional, Hinton, Ardell, additional, Spencer, Anita, additional, Sharma, Santosh, additional, Wiegmann, Thomas, additional, Mehta, Smita, additional, Krause, Michelle, additional, Dishongh, Kate, additional, Childress, Richard, additional, Gyamlani, Geeta, additional, Niakan, Atossa, additional, Thompson, Cathy, additional, Moody, Janelle, additional, Gresham, Carolyn, additional, Whittle, Jeffrey, additional, Barnas, Gary, additional, Wolfgram, Dawn, additional, Cortese, Heidi, additional, Johnson, Jonette, additional, Roumie, Christianne, additional, Hung, Adriana, additional, Wharton, Jennifer, additional, Niesner, Kurt, additional, Katz, Lois, additional, Richardson, Elizabeth, additional, Brock, George, additional, Holland, Joanne, additional, Dixon, Troy, additional, Zias, Athena, additional, Spiller, Christine, additional, Baker, Penelope, additional, Felicetta, James, additional, Rehman, Shakaib, additional, Bingham, Kelli, additional, Watnick, Suzanne, additional, Cohen, David, additional, Weiss, Jessica, additional, Johnston, Tera, additional, Giddings, Stephen, additional, Yamout, Hala, additional, Klein, Andrew, additional, Rowe, Caroline, additional, Vargo, Kristin, additional, Waidmann, Kristi, additional, Papademetriou, Vasilios, additional, Elkhoury, Jean Pierre, additional, Gregory, Barbara, additional, Amodeo, Susan, additional, Bloom, Mary, additional, Goldfarb-Waysman, Dalia, additional, Treger, Richard, additional, Kashefi, Mehran, additional, Huang, Christina, additional, Knibloe, Karen, additional, Ishani, Areef, additional, Slinin, Yelena, additional, Olney, Christine, additional, Rust, Jacqueline, additional, Fanti, Paolo, additional, Dyer, Christopher, additional, Bansal, Shweta, additional, Dunnam, Monica, additional, Hu, Lih-Lan, additional, and Zarate-Abbott, Perla, additional

Published
2022
Full Text
View/download PDF

17. IMPACT OF ANTICOAGULATION THERAPY ON THECOGNITIVE DECLINE AND DEMENTIA IN PATIENTS WITH NON-VALVULARATRIALFIBRILLATION (CAF) TRIAL

Author

Bunch, Thomas Jared, primary, May, Heidi Thomas, additional, Cutler, Michael J., additional, Woller, Scott C., additional, Jacobs, Victoria, additional, Stevens, Scott, additional, Carlquist, John, additional, Knowlton, Kirk U., additional, Muhlestein, J. Brent, additional, Steinberg, Benjamin Adam, additional, and Anderson, Jeffrey L., additional

Published
2022
Full Text
View/download PDF

22. Clonal hematopoiesis is driven by aberrant activation of TCL1A

Author

Weinstock, Joshua S., primary, Gopakumar, Jayakrishnan, additional, Burugula, Bala Bharathi, additional, Uddin, Md Mesbah, additional, Jahn, Nikolaus, additional, Belk, Julia A., additional, Daniel, Bence, additional, Ly, Nghi, additional, Mack, Taralyn M., additional, Laurie, Cecelia A., additional, Broome, Jai G., additional, Taylor, Kent D., additional, Guo, Xiuqing, additional, Sinner, Moritz F., additional, von Falkenhausen, Aenne S., additional, Kääb, Stefan, additional, Shuldiner, Alan R., additional, O’Connell, Jeffrey R., additional, Lewis, Joshua P., additional, Boerwinkle, Eric, additional, Barnes, Kathleen C., additional, Chami, Nathalie, additional, Kenny, Eimear E., additional, Loos, Ruth J., additional, Fornage, Myriam, additional, Hou, Lifang, additional, Lloyd-Jones, Donald M., additional, Redline, Susan, additional, Cade, Brian E., additional, Psaty, Bruce M., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Silverman, Edwin K., additional, Yun, Jeong H., additional, Qiao, Dandi, additional, Palmer, Nicholette D., additional, Freedman, Barry I., additional, Bowden, Donald W., additional, Cho, Michael H., additional, DeMeo, Dawn L., additional, Vasan, Ramachandran S., additional, Yanek, Lisa R., additional, Becker, Lewis C., additional, Kardia, Sharon, additional, Peyser, Patricia A., additional, He, Jiang, additional, Rienstra, Michiel, additional, Harst, Pim Van der, additional, Kaplan, Robert, additional, Heckbert, Susan R., additional, Smith, Nicholas L., additional, Wiggins, Kerri L., additional, Arnett, Donna K., additional, Irvin, Marguerite R., additional, Tiwari, Hemant, additional, Cutler, Michael J., additional, Knight, Stacey, additional, Muhlestein, J Brent., additional, Correa, Adolfo, additional, Raffield, Laura M., additional, Gao, Yan, additional, Andrade, Mariza de, additional, Rotter, Jerome I., additional, Rich, Stephen S., additional, Tracy, Russell P., additional, Konkle, Barbara A., additional, Johnsen, Jill M., additional, Wheeler, Marsha M., additional, Smith, J. Gustav, additional, Melander, Olle, additional, Nilsson, Peter M., additional, Custer, Brian S., additional, Duggirala, Ravindranath, additional, Curran, Joanne E., additional, Blangero, John, additional, McGarvey, Stephen, additional, Williams, L. Keoki, additional, Xiao, Shujie, additional, Yang, Mao, additional, Gu, C. Charles., additional, Chen, Yii-Der Ida., additional, Lee, Wen-Jane, additional, Marcus, Gregory M., additional, Kane, John P., additional, Pullinger, Clive R., additional, Shoemaker, M. Benjamin, additional, Darbar, Dawood, additional, Roden, Dan, additional, Albert, Christine, additional, Kooperberg, Charles, additional, Zhou, Ying, additional, Manson, JoAnn E., additional, Desai, Pinkal, additional, Johnson, Andrew, additional, Mathias, Rasika, additional, Blackwell, Thomas W., additional, Abecasis, Goncalo R., additional, Smith, Albert V., additional, Kang, Hyun M., additional, Satpathy, Ansuman T., additional, Natarajan, Pradeep, additional, Kitzman, Jacob, additional, Whitsel, Eric, additional, Reiner, Alexander P., additional, Bick, Alexander G., additional, and Jaiswal, Sidd, additional

Published
2021
Full Text
View/download PDF

24. IS ROUTINE CORONARY ARTERY CALCIUM SCREENING FOR PRIMARY CARDIOVASCULAR RISK ASSESSMENT COST-EFFECTIVE? INSIGHT FROM THE RANDOMIZED CORCAL TRIAL

Author

Anderson, Jeffrey L., primary, Knowlton, Kirk, additional, Le, Viet, additional, Lappe, Donald, additional, May, Heidi, additional, Min, David, additional, Johnson, Kevin, additional, Cripps, Shanelle T., additional, Schwab, Lesley H., additional, Braun, Shelbi B., additional, Bair, Tami, additional, and Muhlestein, J., additional

Published
2021
Full Text
View/download PDF

26. HIGHER DOCOSAHEXAENOIC ACID LEVELS LOWER THE PROTECTIVE IMPACT OF EICOSAPENTAENOIC ACID ON LONG-TERM MACE IN THOSE WITH AND WITHOUT ANGIOGRAPHIC CAD

Author

Le, Viet T., primary, Knight, Stacey, additional, Knowlton, Kirk, additional, McCubrey, Raymond, additional, Watrous, Jeramie D., additional, Najhawan, Mahan, additional, Dao, Khoi, additional, Bair, Tami, additional, Horne, Benjamin, additional, Muhlestein, J., additional, Lappe, Donald, additional, Taylor, Madisyn, additional, Nelson, John, additional, Carlquist, John, additional, Jain, Mohit, additional, and Anderson, Jeffrey, additional

Published
2021
Full Text
View/download PDF

28. A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD study

Author

Hauser, Elizabeth R., Crossman, David C., Granger, Christopher B., Haines, Jonathan L., Jones, Christopher J.H., Mooser, Vincent, McAdam, Brendan, Winkelmann, Bernhard R., Wiseman, Alan H., Muhlestein, J. Brent, Bartel, Alan G., Dennis, Charles A., Dowdy, Elaine, Estabrooks, Susan, Eggleston, Karen, Francis, Sheila, Roche, Kath, Clevenger, Paula W., Huang, Liling, Pedersen, Bonnie, Shah, Svati, Schmidt, Silke, Haynes, Carol, West, Sandra, Asper, Donny, Booze, Michael, Sharma, Sanjay, Sundseth, Scott, Middleton, Lefkos, Roses, Allen D., Hauser, Michael A., Vance, Jeffery M., Pericak-Vance, Margaret A., and Kraus, William E.

Subjects
Genomes -- Research, Coronary heart disease -- Research, Coronary heart disease -- Influence, Genetic research, Biological sciences
Published
2004

36. EFFECT ON PATIENT ADHERENCE TO PRIMARY PREVENTION RECOMMENDATIONS FOR STATIN THERAPY BASED ON THE NATIONAL GUIDELINES-SUPPORTED POOLED COHORT RISK EQUATION OR A CORONARY ARTERY CALCIUM SCORE: PRELIMINARY FINDINGS FROM THE VANGUARD STUDY FOR THE CORCAL RANDOMIZED CLINICAL OUTCOMES TRIAL

Author

Muhlestein, J. Brent, primary, Knowlton, Kirk, additional, Le, Viet T., additional, Lappe, Donald, additional, May, Heidi, additional, Min, David, additional, Johnson, Kevin, additional, Cripps, Shanelle T., additional, Schwab, Lesley H., additional, Braun, Shelbi B., additional, Bair, Tami, additional, and Anderson, Jeffrey L., additional

Published
2020
Full Text
View/download PDF

39. E valuation of T R eatment With A ngiotensin C onverting E nzyme Inhibitors and the R isk of Lung Cancer: ERACER—An Observational Cohort Study.

Author

Anderson, Jeffrey L., Knowlton, Kirk U., Muhlestein, J. Brent, Bair, Tami L., Le, Viet T., and Horne, Benjamin D.

Subjects
LUNG cancer, ACE inhibitors, DISEASE risk factors, ANGIOTENSIN receptors, MORTALITY
Abstract

Introduction: Angiotensin converting enzyme inhibitors (ACEIs) are widely prescribed medications. A recent British study reported a 14% increased risk of lung cancer with ACEI versus angiotensin receptor blocker (ARB) prescriptions, and risk increased with longer use. We sought to validate this observation. Methods: We searched the Intermountain Enterprise Data Warehouse from 1996 to 2018 for patients newly treated with an ACEI or an ARB and with ≥1 year's follow-up or to incident lung cancer or death. Unadjusted and adjusted hazard ratios (HRs) for lung cancer and for lung cancer or all-cause mortality were calculated for ACEIs compared to ARBs. Results: A total of 187,060 patients met entry criteria (age 60.2 ± 15.1 y; 51% women). During a mean of 7.1 years follow-up (max: 20.0 years), 3,039 lung cancers and 43,505 deaths occurred. Absolute lung cancer rates were 2.16 and 2.31 per 1000 patient-years in the ARB and ACEI groups, respectively. The HR of lung cancer was modestly increased with ACEIs (unadjusted HR = 1.11, CI: 1.02, 1.22, P =.014; adjusted HR = 1.18, CI: 1.06, 1.31, P =.002; number needed to harm [NNH] 6,667). Rates of the composite of lung cancer or death over time also favored ARBs. Lung cancer event curves separated gradually over longitudinal follow-up beginning at 10-12 years. Conclusions: We noted a small long-term increase in lung cancer risk with ACEIs compared with ARBs. Separation of survival curves was delayed until 10-12 years after treatment initiation. Although the observed increases in lung cancer risk are small, implications are potentially important because of the broad use of ACEIs. Thus, additional work to validate these findings is needed. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

41. DISCOVERY OF NOVEL TITIN (TTN) GENE TRUNCATING MUTATIONS AMONG A CONSECUTIVE COHORT OF PATIENTS PRESENTING WITH IDIOPATHIC DILATED CARDIOMYOPATHY (IDC)

Author

Anderson, Jeffrey L., primary, Jacobs, Victoria, additional, Christensen, G. Bryce, additional, Escobar, Helaman, additional, Horne, Benjamin, additional, Knight, Stacey, additional, Afshar, Kia, additional, Hebl, Virginia B., additional, Knowlton, Kirk, additional, Muhlestein, J., additional, Carlquist, John, additional, and Nadauld, Lincoln D., additional

Published
2019
Full Text
View/download PDF

44. CORONARY ARTERY CALCIUM IS ASSOCIATED WITH 90-DAY MACE AT ANY LEVEL OF ISCHEMIC BURDEN IN PATIENTS REFERRED FOR PET/CT

Author

Le, Viet T., primary, Knight, Stacey, additional, McCubrey, Raymond, additional, Horne, Benjamin, additional, Jensen, Kurt, additional, Meredith, Kent, additional, Lappe, Donald, additional, Mason, Steve, additional, Min, David, additional, Anderson, Jeffrey, additional, Muhlestein, J., additional, and Knowlton, Kirk, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results