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Your search keyword '"Mui, Chun Wai"' showing total 6 results
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6 results on '"Mui, Chun Wai"'

1. STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker

Author

Chen, Bonan, Chan, Wai Nok, Mui, Chun Wai, Liu, Xiaoli, Zhang, Jinglin, Wang, Yifei, Cheung, Alvin H. K., Chan, Aden K. Y., Chan, Ronald C. K., Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Wong, Chi Chun, Wu, William K. K., Cheng, Alfred S. L., Yu, Jun, Lo, Kwok Wai, To, Ka Fai, and Kang, Wei

Published
2021
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2. The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas

Author

Chen, Bonan, primary, Chan, Wai Nok, additional, Xie, Fuda, additional, Mui, Chun Wai, additional, Liu, Xiaoli, additional, Cheung, Alvin H. K., additional, Lung, Raymond W. M., additional, Chow, Chit, additional, Zhang, Zhenhua, additional, Fang, Canbin, additional, Yu, Peiyao, additional, Shi, Shihua, additional, Zhou, Shikun, additional, Chen, Guoming, additional, Wang, Zhangding, additional, Wang, Shouyu, additional, Ding, Xiaofan, additional, Huang, Bing, additional, Liang, Li, additional, Dong, Yujuan, additional, Wong, Chi Chun, additional, Wu, William K. K., additional, Cheng, Alfred S. L., additional, Wong, Nathalie, additional, Yu, Jun, additional, Lo, Kwok Wai, additional, Tse, Gary M. K., additional, Kang, Wei, additional, and To, Ka Fai, additional

Published
2023
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3. The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional profiling

Author

Chen, Bonan, primary, Chan, Wai Nok, additional, Xie, Fuda, additional, Mui, Chun Wai, additional, Cheung, Alvin H.K., additional, liu, Xiaoli, additional, Lung, Raymond W.M., additional, Chow, Chit, additional, Zhang, Zhenhua, additional, Shi, Shihua, additional, Zhou, Shikun, additional, Chen, Guoming, additional, WangP, Shouyu, additional, Ding, Xiaofan, additional, Huang, Bing, additional, Liang, Li, additional, Dong, Yujuan, additional, Wong, Chi Chun, additional, Wu, William K.K., additional, Cheng, Alfred S.L., additional, Chan, Michael W.Y., additional, Yu, Jun, additional, Lo, Kwok Wai, additional, Kang, Wei, additional, and To, Ka Fai, additional

Published
2023
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6. Targeting YAP1/TAZ in nonsmall‐cell lung carcinoma: From molecular mechanisms to precision medicine.

Author

Mui, Chun Wai, Chan, Wai Nok, Chen, Bonan, Cheung, Alvin Ho‐Kwan, Yu, Jun, Lo, Kwok Wai, Ke, Huixing, Kang, Wei, and To, Ka Fai

Subjects
HIPPO signaling pathway, INDIVIDUALIZED medicine, LUNGS, SMALL molecules, PROTEIN-tyrosine kinases, KINASES
Abstract

Accumulating evidence has underscored the importance of the Hippo‐YAP1 signaling in lung tissue homeostasis, whereas its deregulation induces tumorigenesis. YAP1 and its paralog TAZ are the key downstream effectors tightly controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In solid tumors, Hippo‐YAP1 crosstalks with other signaling pathways such as Wnt/β‐catenin, receptor tyrosine kinase cascade, Notch and TGF‐β to synergistically drive tumorigenesis. As YAP1/TAZ expression is significantly correlated with unfavorable outcomes for the patients, small molecules have been developed for targeting YAP1/TAZ to get a therapeutic effect. In this review, we summarize the recent findings on the deregulation of Hippo‐YAP1 pathway in nonsmall cell lung carcinoma, discuss the molecular mechanisms of its dysregulation in leading to tumorigenesis, explore the therapeutic strategies for targeting YAP1/TAZ, and provide the research directions for deep investigation. We believe that detailed delineation of Hippo‐YAP1 regulation in tumorigenesis provides novel insight for accurate therapeutic intervention. [ABSTRACT FROM AUTHOR]

Published
2023
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