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19 results on '"Mullally, Christopher A."'

1. A concerted neuron–astrocyte program declines in ageing and schizophrenia

Author

Ling, Emi, Nemesh, James, Goldman, Melissa, Kamitaki, Nolan, Reed, Nora, Handsaker, Robert E., Genovese, Giulio, Vogelgsang, Jonathan S., Gerges, Sherif, Kashin, Seva, Ghosh, Sulagna, Esposito, John M., Morris, Kiely, Meyer, Daniel, Lutservitz, Alyssa, Mullally, Christopher D., Wysoker, Alec, Spina, Liv, Neumann, Anna, Hogan, Marina, Ichihara, Kiku, Berretta, Sabina, and McCarroll, Steven A.

Published
2024
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2. Early role for a Na+,K+-ATPase (ATP1A3) in brain development

Author

Smith, Richard S, Florio, Marta, Akula, Shyam K, Neil, Jennifer E, Wang, Yidi, Hill, R Sean, Goldman, Melissa, Mullally, Christopher D, Reed, Nora, Bello-Espinosa, Luis, Flores-Sarnat, Laura, Monteiro, Fabiola Paoli, Erasmo, Casella B, Pinto E Vairo, Filippo, Morava, Eva, Barkovich, A James, Gonzalez-Heydrich, Joseph, Brownstein, Catherine A, McCarroll, Steven A, and Walsh, Christopher A

Subjects
Pediatric, Neurosciences, Genetics, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Adult, Brain, Child, Female, Fetus, Gene Expression Regulation, Developmental, Humans, Infant, Infant, Newborn, Interneurons, Magnetic Resonance Imaging, Male, Mutation, Neocortex, Neurons, Parvalbumins, Phenotype, Polymicrogyria, RNA, Messenger, Single-Cell Analysis, Sodium-Potassium-Exchanging ATPase, cortex development, ATP1A3, developmental channelopathy, polymicrogyria, cortical malformation
Abstract

Osmotic equilibrium and membrane potential in animal cells depend on concentration gradients of sodium (Na+) and potassium (K+) ions across the plasma membrane, a function catalyzed by the Na+,K+-ATPase α-subunit. Here, we describe ATP1A3 variants encoding dysfunctional α3-subunits in children affected by polymicrogyria, a developmental malformation of the cerebral cortex characterized by abnormal folding and laminar organization. To gain cell-biological insights into the spatiotemporal dynamics of prenatal ATP1A3 expression, we built an ATP1A3 transcriptional atlas of fetal cortical development using mRNA in situ hybridization and transcriptomic profiling of ∼125,000 individual cells with single-cell RNA sequencing (Drop-seq) from 11 areas of the midgestational human neocortex. We found that fetal expression of ATP1A3 is most abundant to a subset of excitatory neurons carrying transcriptional signatures of the developing subplate, yet also maintains expression in nonneuronal cell populations. Moving forward a year in human development, we profiled ∼52,000 nuclei from four areas of an infant neocortex and show that ATP1A3 expression persists throughout early postnatal development, most predominantly in inhibitory neurons, including parvalbumin interneurons in the frontal cortex. Finally, we discovered the heteromeric Na+,K+-ATPase pump complex may form nonredundant cell-type-specific α-β isoform combinations, including α3-β1 in excitatory neurons and α3-β2 in inhibitory neurons. Together, the developmental malformation phenotype of affected individuals and single-cell ATP1A3 expression patterns point to a key role for α3 in human cortex development, as well as a cell-type basis for pre- and postnatal ATP1A3-associated diseases.

Published
2021

3. Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease

Author

Handsaker, Robert E., primary, Kashin, Seva, additional, Reed, Nora M., additional, Tan, Steven, additional, Lee, Won-Seok, additional, McDonald, Tara M., additional, Morris, Kiely, additional, Kamitaki, Nolan, additional, Mullally, Christopher D., additional, Morakabati, Neda, additional, Goldman, Melissa, additional, Lind, Gabriel, additional, Kohli, Rhea, additional, Lawton, Elisabeth, additional, Hogan, Marina, additional, Ichihara, Kiku, additional, Berretta, Sabina, additional, and McCarroll, Steven A., additional

Published
2024
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4. Concerted neuron-astrocyte gene expression declines in aging and schizophrenia

Author

Ling, Emi, primary, Nemesh, James, additional, Goldman, Melissa, additional, Kamitaki, Nolan, additional, Reed, Nora, additional, Handsaker, Robert E., additional, Genovese, Giulio, additional, Vogelgsang, Jonathan S., additional, Gerges, Sherif, additional, Kashin, Seva, additional, Ghosh, Sulagna, additional, Esposito, John M., additional, French, Kiely, additional, Meyer, Daniel, additional, Lutservitz, Alyssa, additional, Mullally, Christopher D., additional, Wysoker, Alec, additional, Spina, Liv, additional, Neumann, Anna, additional, Hogan, Marina, additional, Ichihara, Kiku, additional, Berretta, Sabina, additional, and McCarroll, Steven A., additional

Published
2024
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6. Genomic characterization of a unique Panton–Valentine leucocidin-positive community-associated methicillin-resistant Staphylococcus aureus lineage increasingly impacting on Australian indigenous communities

Author

Ramsay, Joshua P., primary, Parahitiyawa, Nipuna, additional, Mowlaboccus, Shakeel, additional, Mullally, Christopher A., additional, Yee, Nicholas W.T., additional, Shoby, Princy, additional, Colombi, Elena, additional, Tan, Hui-Leen, additional, Pearson, Julie C., additional, and Coombs, Geoffrey W., additional

Published
2023
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8. Innovations present in the primate interneuron repertoire

Author

Krienen, Fenna M., Goldman, Melissa, Zhang, Qiangge, C. H. del Rosario, Ricardo, Florio, Marta, Machold, Robert, Saunders, Arpiar, Levandowski, Kirsten, Zaniewski, Heather, Schuman, Benjamin, Wu, Carolyn, Lutservitz, Alyssa, Mullally, Christopher D., Reed, Nora, Bien, Elizabeth, Bortolin, Laura, Fernandez-Otero, Marian, Lin, Jessica D., Wysoker, Alec, Nemesh, James, Kulp, David, Burns, Monika, Tkachev, Victor, Smith, Richard, Walsh, Christopher A., Dimidschstein, Jordane, Rudy, Bernardo, S. Kean, Leslie, Berretta, Sabina, Fishell, Gord, Feng, Guoping, and McCarroll, Steven A.

Published
2020
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9. Author Correction: Innovations present in the primate interneuron repertoire

Author

Krienen, Fenna M., Goldman, Melissa, Zhang, Qiangge, del Rosario, Ricardo C. H., Florio, Marta, Machold, Robert, Saunders, Arpiar, Levandowski, Kirsten, Zaniewski, Heather, Schuman, Benjamin, Wu, Carolyn, Lutservitz, Alyssa, Mullally, Christopher D., Reed, Nora, Bien, Elizabeth, Bortolin, Laura, Fernandez-Otero, Marian, Lin, Jessica D., Wysoker, Alec, Nemesh, James, Kulp, David, Burns, Monika, Tkachev, Victor, Smith, Richard, Walsh, Christopher A., Dimidschstein, Jordane, Rudy, Bernardo, Kean, Leslie S., Berretta, Sabina, Fishell, Gord, Feng, Guoping, and McCarroll, Steven A.

Published
2020
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10. Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase

Author

Mullally, Christopher, primary, Stubbs, Keith A, additional, Thai, Van C, additional, Anandan, Anandhi, additional, Bartley, Stephanie, additional, Scanlon, Martin J, additional, Jarvis, Gary A, additional, John, Constance M, additional, Lim, Katherine Y L, additional, Sullivan, Courtney M, additional, Sarkar-Tyson, Mitali, additional, Vrielink, Alice, additional, and Kahler, Charlene M, additional

Published
2022
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12. Early role for a Na + ,K + -ATPase ( ATP1A3 ) in brain development

Author

Smith, Richard S., primary, Florio, Marta, additional, Akula, Shyam K., additional, Neil, Jennifer E., additional, Wang, Yidi, additional, Hill, R. Sean, additional, Goldman, Melissa, additional, Mullally, Christopher D., additional, Reed, Nora, additional, Bello-Espinosa, Luis, additional, Flores-Sarnat, Laura, additional, Monteiro, Fabiola Paoli, additional, Erasmo, Casella B., additional, Pinto e Vairo, Filippo, additional, Morava, Eva, additional, Barkovich, A. James, additional, Gonzalez-Heydrich, Joseph, additional, Brownstein, Catherine A., additional, McCarroll, Steven A., additional, and Walsh, Christopher A., additional

Published
2021
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13. Anti-Virulence Therapeutic Approaches for Neisseria gonorrhoeae

Author

Lim, Katherine Y. L., primary, Mullally, Christopher A., additional, Haese, Ethan C., additional, Kibble, Emily A., additional, McCluskey, Nicolie R., additional, Mikucki, Edward C., additional, Thai, Van C., additional, Stubbs, Keith A., additional, Sarkar-Tyson, Mitali, additional, and Kahler, Charlene M., additional

Published
2021
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14. Role for the Na+/K+ ATPase pump alpha 3 (ATP1A3) subunit in folding and lamination of the human neocortex

Author

Smith, Richard S., primary, Florio, Marta, additional, Akula, Shyam K., additional, Neil, Jennifer E., additional, Wang, Yidi, additional, Hill, R. Sean, additional, Goldman, Melissa, additional, Mullally, Christopher D., additional, Reed, Nora, additional, Bello-Espinosa, Luis, additional, Flores-Sarnat, Laura, additional, Monteiro, Fabiola Paoli, additional, Erasmo, Casella B., additional, e Vairo, Filippo Pinto, additional, Morava, Eva, additional, Barkovich, A. James, additional, Gonzalez-Heydrich, Joseph, additional, Brownstein, Catherine A., additional, McCarroll, Steven A., additional, and Walsh, Christopher A., additional

Published
2020
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15. Innovations in Primate Interneuron Repertoire

Author

Krienen, Fenna M., primary, Goldman, Melissa, additional, Zhang, Qiangge, additional, del Rosario, Ricardo, additional, Florio, Marta, additional, Machold, Robert, additional, Saunders, Arpiar, additional, Levandowski, Kirsten, additional, Zaniewski, Heather, additional, Schuman, Benjamin, additional, Wu, Carolyn, additional, Lutservitz, Alyssa, additional, Mullally, Christopher D., additional, Reed, Nora, additional, Bien, Elizabeth, additional, Bortolin, Laura, additional, Fernandez-Otero, Marian, additional, Lin, Jessica, additional, Wysoker, Alec, additional, Nemesh, James, additional, Kulp, David, additional, Burns, Monika, additional, Tkachev, Victor, additional, Smith, Richard, additional, Walsh, Christopher A., additional, Dimidschstein, Jordane, additional, Rudy, Bernardo, additional, Kean, Leslie, additional, Berretta, Sabina, additional, Fishell, Gord, additional, Feng, Guoping, additional, and McCarroll, Steven A., additional

Published
2019
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16. Differences in the population structure of Neisseria meningitidis in two Australian states: Victoria and Western Australia

Author

Mowlaboccus, Shakeel, primary, Mullally, Christopher A., additional, Richmond, Peter C., additional, Howden, Benjamin P., additional, Stevens, Kerrie, additional, Speers, David J., additional, Keil, Anthony D., additional, Bjørnstad, Ottar N., additional, Perkins, Timothy T., additional, and Kahler, Charlene M., additional

Published
2017
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18. Non- faecium non- faecalis enterococci: a review of clinical manifestations, virulence factors, and antimicrobial resistance.

Author

Mullally CA, Fahriani M, Mowlaboccus S, and Coombs GW

Subjects
Humans, Animals, Drug Resistance, Bacterial, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Enterococcus pathogenicity, Enterococcus drug effects, Enterococcus genetics, Virulence, Gram-Positive Bacterial Infections microbiology, Gram-Positive Bacterial Infections drug therapy, Virulence Factors genetics
Abstract

SUMMARYEnterococci are a diverse group of Gram-positive bacteria that are typically found as commensals in humans, animals, and the environment. Occasionally, they may cause clinically relevant diseases such as endocarditis, septicemia, urinary tract infections, and wound infections. The majority of clinical infections in humans are caused by two species: Enterococcus faecium and Enterococcus faecalis . However, there is an increasing number of clinical infections caused by non- faecium non- faecalis (NFF) enterococci. Although NFF enterococcal species are often overlooked, studies have shown that they may harbor antimicrobial resistance (AMR) genes and virulence factors that are found in E. faecium and E. faecalis . In this review, we present an overview of the NFF enterococci with a particular focus on human clinical manifestations, epidemiology, virulence genes, and AMR genes., Competing Interests: The authors declare no conflict of interest.

Published
2024
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