Search

Your search keyword '"Mullen, Peter"' showing total 445 results
Start Over Author "Mullen, Peter"
445 results on '"Mullen, Peter"'

1. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Author

Halbrook, Christopher J, Thurston, Galloway, Boyer, Seth, Anaraki, Cecily, Jiménez, Jennifer A, McCarthy, Amy, Steele, Nina G, Kerk, Samuel A, Hong, Hanna S, Lin, Lin, Law, Fiona V, Felton, Catherine, Scipioni, Lorenzo, Sajjakulnukit, Peter, Andren, Anthony, Beutel, Alica K, Singh, Rima, Nelson, Barbara S, Van Den Bergh, Fran, Krall, Abigail S, Mullen, Peter J, Zhang, Li, Batra, Sandeep, Morton, Jennifer P, Stanger, Ben Z, Christofk, Heather R, Digman, Michelle A, Beard, Daniel A, Viale, Andrea, Zhang, Ji, Crawford, Howard C, Pasca di Magliano, Marina, Jorgensen, Claus, and Lyssiotis, Costas A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Digestive Diseases, Pancreatic Cancer, Cancer, 2.1 Biological and endogenous factors, Animals, Mice, Humans, Pancreatic Neoplasms, Asparagine, Adenocarcinoma, Symbiosis, Tumor Microenvironment, Immunology, Oncology and carcinogenesis
Abstract

The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate. Pancreatic cancer subtypes have been characterized by transcriptional and functional differences, with subtypes reported to exist within the same tumor. However, it remains unclear if this diversity extends to metabolic programming. Here, using metabolomic profiling and functional interrogation of metabolic dependencies, we identify two distinct metabolic subclasses among neoplastic populations within individual human and mouse tumors. Furthermore, these populations are poised for metabolic cross-talk, and in examining this, we find an unexpected role for asparagine supporting proliferation during limited respiration. Constitutive GCN2 activation permits ATF4 signaling in one subtype, driving excess asparagine production. Asparagine release provides resistance during impaired respiration, enabling symbiosis. Functionally, availability of exogenous asparagine during limited respiration indirectly supports maintenance of aspartate pools, a rate-limiting biosynthetic precursor. Conversely, depletion of extracellular asparagine with PEG-asparaginase sensitizes tumors to mitochondrial targeting with phenformin.

Published
2022

3. Objective Multi-variable Classification and Inference of Biological Neuronal Networks

Author

Barros, Michael Taynnan, Siljak, Harun, Mullen, Peter, Papadias, Constantinos, Hyttinen, Jari, and Marchetti, Nicola

Subjects
Quantitative Biology - Neurons and Cognition, Computer Science - Other Computer Science
Abstract

Classification of biological neuron types and networks poses challenges to the full understanding of the brain's organisation and functioning. In this paper, we develop a novel objective classification model of biological neuronal types and networks based on the communication metrics of neurons. This presents advantages against the existing approaches since the mutual information or the delay between neurons obtained from spike trains are more abundant data compare to conventional morphological data. We firstly designed two open-access supporting computational platforms of various neuronal circuits from the Blue Brain Project realistic models, named Neurpy and Neurgen. Then we investigate how the concept of network tomography could be achieved with cortical neuronal circuits for morphological, topological and electrical classification of neurons. We extract the simulated data to many different classifiers (including SVM, Decision Trees, Random Forest, and Artificial Neuron Networks) classifying the specific cell type (and sub-group types) achieving accuracies of up to 70\%. Inference of biological network structures using network tomography reached up to 65\% of accuracy. We also analysed recall, precision and F1score of the classification of five layers, 25 cell m-types, and 14 cell e-types. Our research not only contributes to existing classification efforts but sets the road-map for future usage of cellular-scaled brain-machine interfaces for in-vivo objective classification of neurons as a sensing mechanism of the brain's structure.

Published
2020

4. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

Author

Krall, Abigail S, Mullen, Peter J, Surjono, Felicia, Momcilovic, Milica, Schmid, Ernst W, Halbrook, Christopher J, Thambundit, Apisadaporn, Mittelman, Steven D, Lyssiotis, Costas A, Shackelford, David B, Knott, Simon RV, and Christofk, Heather R

Subjects
Cancer, Activating Transcription Factor 4, Animals, Asparagine, Aspartic Acid, Cell Line, Tumor, Cell Proliferation, Diet, Electron Transport Chain Complex Proteins, Humans, Mechanistic Target of Rapamycin Complex 1, Metformin, Mice, Mice, Inbred NOD, Mitochondria, Neoplasms, Nucleotides, Survival Rate, asparaginase, asparagine, cancer metabolism, cancer treatment, dietary restriction, metformin, respiration, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism
Abstract

Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP, respiration generates biosynthetic precursors, such as aspartate, an essential substrate for nucleotide synthesis. Here, we show that in addition to depleting intracellular aspartate, electron transport chain (ETC) inhibition depletes aspartate-derived asparagine, increases ATF4 levels, and impairs mTOR complex I (mTORC1) activity. Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1. Finally, we show that combination of the ETC inhibitor metformin, which limits tumor asparagine synthesis, and either asparaginase or dietary asparagine restriction, which limit tumor asparagine consumption, effectively impairs tumor growth in multiple mouse models of cancer. Because environmental asparagine is sufficient to restore tumor growth in the context of respiration impairment, our findings suggest that asparagine synthesis is a fundamental purpose of tumor mitochondrial respiration, which can be harnessed for therapeutic benefit to cancer patients.

Published
2021

6. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.

Author

Mullen, Peter J, Garcia, Gustavo, Purkayastha, Arunima, Matulionis, Nedas, Schmid, Ernst W, Momcilovic, Milica, Sen, Chandani, Langerman, Justin, Ramaiah, Arunachalam, Shackelford, David B, Damoiseaux, Robert, French, Samuel W, Plath, Kathrin, Gomperts, Brigitte N, Arumugaswami, Vaithilingaraja, and Christofk, Heather R

Subjects
Lung, Cell Line, Vero Cells, Animals, Humans, Benzamides, Morpholines, Pyrimidines, Naphthyridines, Pyruvate Carboxylase, Glucose, Glutamine, Protein Kinase Inhibitors, Virus Replication, Citric Acid Cycle, HEK293 Cells, Mechanistic Target of Rapamycin Complex 1, Chlorocebus aethiops, COVID-19, SARS-CoV-2, Infectious Diseases, Pneumonia, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Respiratory, Infection
Abstract

Viruses hijack host cell metabolism to acquire the building blocks required for replication. Understanding how SARS-CoV-2 alters host cell metabolism may lead to potential treatments for COVID-19. Here we profile metabolic changes conferred by SARS-CoV-2 infection in kidney epithelial cells and lung air-liquid interface (ALI) cultures, and show that SARS-CoV-2 infection increases glucose carbon entry into the TCA cycle via increased pyruvate carboxylase expression. SARS-CoV-2 also reduces oxidative glutamine metabolism while maintaining reductive carboxylation. Consistent with these changes, SARS-CoV-2 infection increases the activity of mTORC1 in cell lines and lung ALI cultures. Lastly, we show evidence of mTORC1 activation in COVID-19 patient lung tissue, and that mTORC1 inhibitors reduce viral replication in kidney epithelial cells and lung ALI cultures. Our results suggest that targeting mTORC1 may be a feasible treatment strategy for COVID-19 patients, although further studies are required to determine the mechanism of inhibition and potential efficacy in patients.

Published
2021

8. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

Author

Sullivan, William J, Mullen, Peter J, Schmid, Ernst W, Flores, Aimee, Momcilovic, Milica, Sharpley, Mark S, Jelinek, David, Whiteley, Andrew E, Maxwell, Matthew B, Wilde, Blake R, Banerjee, Utpal, Coller, Hilary A, Shackelford, David B, Braas, Daniel, Ayer, Donald E, de Aguiar Vallim, Thomas Q, Lowry, William E, and Christofk, Heather R

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Underpinning research, 1.1 Normal biological development and functioning, Carbohydrate Metabolism, Carrier Proteins, Cell Line, Tumor, Extracellular Matrix, Glucose, Glucose Transporter Type 1, Glycolysis, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Intercellular Signaling Peptides and Proteins, Signal Transduction, Tristetraprolin, GLUT1 trafficking, TXNIP, ZFP36, cell biology, cell migration, extracellular matrix, glucose metabolism, hyaluronidase, mRNA degradation, receptor tyrosine kinase signaling, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulation. Unbiased analysis of glycolytic drivers identified the hyaluronan-mediated motility receptor as being among the most highly correlated with glycolysis in cancer. Confirming a mechanistic link between the ECM component hyaluronan and metabolism, treatment of cells and xenografts with hyaluronidase triggers a robust increase in glycolysis. This is largely achieved through rapid receptor tyrosine kinase-mediated induction of the mRNA decay factor ZFP36, which targets TXNIP transcripts for degradation. Because TXNIP promotes internalization of the glucose transporter GLUT1, its acute decline enriches GLUT1 at the plasma membrane. Functionally, induction of glycolysis by hyaluronidase is required for concomitant acceleration of cell migration. This interconnection between ECM remodeling and metabolism is exhibited in dynamic tissue states, including tumorigenesis and embryogenesis.

Published
2018

14. On the possibility of authentic Christian spirituality in the post-critical age

Author

Mullen, Peter

Subjects
248.4
Abstract

This project consists of three of my books (plus 2 chapters in another) and a summary statement on the topic entitled above. The books are: Being Saved (London, SCM 1985); Death Be Not Proud (London, Collins Fount 1989); Reason To Believe (London, Sinclair-Stevenson 1995); and the chapters appear in Anderson and Mullen ed; Faking It: The Sentimentalising of Society (London, The St Edmundsbury Press 1998). In Being Saved I made an extended comparison between the doctrines of traditional Christianity and the psychological theory C.G. Jung showing how these systems can cross-reference and cross-fertilise each other; and concluding that authentic spirituality can be enriched by such a comparison, but explicitly not concluding that Christian doctrine can be reduced to Jungian terms. In Death Be Not Proud I attempted a phenomenological study of the idea and experience of death and considered how this may be approached from the point of our awareness of the certainty of our own death and from the point of the bereaved. The book includes a sympathetic reflection on suicide and an argument for the trith of the doctrine of the resurrection to eternal life. Reason To Believe is a book of apologetics for the principal doctrines of Christianity as found in the Apostles' Creed, an argument for traditional texts in religious education and worship and a defence of the institutional church. In Faking It evidenced the widespread sentimentality in much contemporary worship and religious teaching and I identified this as an example of sentimentality which, religiously applied, I identified as inauthentic spirituality. The works show a continuity and development of though supported by a considerable project of reading and reflection which can be traced in the notes and bibliography.

Published
2000

15. Supplementary Figures 1-2, Supplementary Tables 1-2 from Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer

Author

Stewart, Grant D., primary, O'Mahony, Fiach C., primary, Laird, Alexander, primary, Eory, Lel, primary, Lubbock, Alexander L.R., primary, Mackay, Alan, primary, Nanda, Jyoti, primary, O'Donnell, Marie, primary, Mullen, Peter, primary, McNeill, S. Alan, primary, Riddick, Antony C.P., primary, Berney, Daniel, primary, Bex, Axel, primary, Aitchison, Michael, primary, Overton, Ian M., primary, Harrison, David J., primary, and Powles, Thomas, primary

Published
2023
Full Text
View/download PDF

17. Supplementary Figures S1-S4 from Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies

Author

Faratian, Dana, primary, Zweemer, Annelien J.M., primary, Nagumo, Yoko, primary, Sims, Andrew H., primary, Muir, Morwenna, primary, Dodds, Michael, primary, Mullen, Peter, primary, Um, Inhwa, primary, Kay, Charlene, primary, Hasmann, Max, primary, Harrison, David J., primary, and Langdon, Simon P., primary

Published
2023
Full Text
View/download PDF

18. Data from Trastuzumab and Pertuzumab Produce Changes in Morphology and Estrogen Receptor Signaling in Ovarian Cancer Xenografts Revealing New Treatment Strategies

Author

Faratian, Dana, primary, Zweemer, Annelien J.M., primary, Nagumo, Yoko, primary, Sims, Andrew H., primary, Muir, Morwenna, primary, Dodds, Michael, primary, Mullen, Peter, primary, Um, Inhwa, primary, Kay, Charlene, primary, Hasmann, Max, primary, Harrison, David J., primary, and Langdon, Simon P., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Table 1 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Table 3 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

22. Supplementary Table 5 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Table 4 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

28. Data from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Figures from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

30. Supplementary Table 2 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

31. Supplementary Figure 1 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

32. Supplementary Methods, Figures 1-16 from Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab

Author

Faratian, Dana, primary, Goltsov, Alexey, primary, Lebedeva, Galina, primary, Sorokin, Anatoly, primary, Moodie, Stuart, primary, Mullen, Peter, primary, Kay, Charlene, primary, Um, In Hwa, primary, Langdon, Simon, primary, Goryanin, Igor, primary, and Harrison, David J., primary

Published
2023
Full Text
View/download PDF

33. Supplementary Figure 2 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

34. Supplementary Materials and Methods from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Table 1 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

36. Supplementary Table 5 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

38. Supplementary Figure 3 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

39. Supplementary Table 6 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figure Legends 1-3 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

41. Supplementary Table 9 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

42. Supplementary Table 7 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

43. Supplementary Table 2 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Author

Wasylishen, Amanda R., primary, Chan-Seng-Yue, Michelle, primary, Bros, Christina, primary, Dingar, Dharmendra, primary, Tu, William B., primary, Kalkat, Manpreet, primary, Chan, Pak-Kei, primary, Mullen, Peter J., primary, Huang, Ling, primary, Meyer, Natalie, primary, Raught, Brian, primary, Boutros, Paul C., primary, and Penn, Linda Z., primary

Published
2023
Full Text
View/download PDF

44. Supplementary Table 4 from Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

Author

Hochgräfe, Falko, primary, Zhang, Luxi, primary, O'Toole, Sandra A., primary, Browne, Brigid C., primary, Pinese, Mark, primary, Porta Cubas, Ana, primary, Lehrbach, Gillian M., primary, Croucher, David R., primary, Rickwood, Danny, primary, Boulghourjian, Alice, primary, Shearer, Robert, primary, Nair, Radhika, primary, Swarbrick, Alexander, primary, Faratian, Dana, primary, Mullen, Peter, primary, Harrison, David J., primary, Biankin, Andrew V., primary, Sutherland, Robert L., primary, Raftery, Mark J., primary, and Daly, Roger J., primary

Published
2023
Full Text
View/download PDF

46. AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Author

Sriskanthadevan, Shrivani, Jeyaraju, Danny V., Chung, Timothy E., Prabha, Swayam, Xu, Wei, Skrtic, Marko, Jhas, Bozhena, Hurren, Rose, Gronda, Marcela, Wang, Xiaoming, Jitkova, Yulia, Sukhai, Mahadeo A., Lin, Feng-Hsu, Maclean, Neil, Laister, Rob, Goard, Carolyn A., Mullen, Peter J., Xie, Stephanie, Penn, Linda Z., Rogers, Ian M., Dick, John E., Minden, Mark D., and Schimmer, Aaron D.

Published
2015
Full Text
View/download PDF

47. Carbonic Anhydrase 9 Expression Increases with Vascular Endothelial Growth Factor–Targeted Therapy and Is Predictive of Outcome in Metastatic Clear Cell Renal Cancer

Author

Stewart, Grant D., O’Mahony, Fiach C., Laird, Alexander, Rashid, Sukaina, Martin, Sarah A., Eory, Lel, Lubbock, Alexander L.R., Nanda, Jyoti, O’Donnell, Marie, Mackay, Alan, Mullen, Peter, McNeill, S. Alan, Riddick, Antony C.P., Aitchison, Michael, Berney, Daniel, Bex, Axel, Overton, Ian M., Harrison, David J., and Powles, Thomas

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results