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2. Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology

Author

Bonifay, Amandine, Mackman, Nigel, Hisada, Yohei, Sachetto, Ana Teresa Azevedo, Hau, Chi, Gray, Elaine, Hogwood, John, Aharon, Anat, Badimon, Lina, Barile, Lucio, Baudar, Justine, Beckmann, Lennart, Benedikter, Birke, Bolis, Sara, Bouriche, Tarik, Brambilla, Marta, Burrello, Jacopo, Camera, Marina, Campello, Elena, Ettelaie, Camille, Faille, Dorothée, Featherby, Sophie, Franco, Corentin, Guldenpfennig, Maite, Hansen, John-Bjarne, Judicone, Coralie, Kim, Yohan, Kristensen, Soren Risom, Laakmann, Katrin, Langer, Florian, Latysheva, Nadezhda, Lucien, Fabrice, de Menezes, Erika Marques, Mullier, François, Norris, Philip, Nybo, Jette, Orbe, Josune, Osterud, Bjarne, Paramo, Jose A., Radu, Claudia M., Roncal, Carmen, Samadi, Nazanin, Snir, Omri, Suades, Rosa, Wahlund, Casper, Chareyre, Corinne, Abdili, Evelyne, Martinod, Kimberly, Thaler, Johannes, Dignat-George, Françoise, Nieuwland, Rienk, and Lacroix, Romaric

Published
2024
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4. The use of 1E12, a monoclonal anti-platelet factor 4 antibody, to improve the diagnosis of vaccine-induced immune thrombotic thrombocytopenia

Author

Vayne, Caroline, Rollin, Jérôme, Clare, Rumi, Daka, Mercy, Atsouawe, Merveille, Guéry, Eve-Anne, Cauchie, Philippe, Cordonnier, Charlotte, Cuisenier, Pauline, De Maistre, Emmanuel, Donnard, Magali, Drillaud, Nicolas, Faille, Dorothée, Galinat, Hubert, Gouin-Thibault, Isabelle, Lemoine, Sandrine, Mourey, Guillaume, Mullier, François, Siguret, Virginie, Susen, Sophie, Godon, Alban, Nazy, Ishac, Gruel, Yves, and Pouplard, Claire

Published
2024
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9. Multicenter evaluation of light transmission platelet aggregation reagents: communication from the ISTH SSC Subcommittee on Platelet Physiology

Author

Alessi, Marie-Christine, Coxon, Carmen, Ibrahim-Kosta, Manal, Bacci, Monica, Voisin, Sophie, Rivera, José, Greinacher, Andreas, Raster, Johannes, Pulcinelli, Fabio, Devreese, Katrien M.J., Mullier, Francois, McCormick, Aine N., Frontroth, Juan Pablo, Pouplard, Claire, Sachs, Ulrich J., Diaz, Isabelle, Bermejo, Nuria, Camera, Marina, Fontana, Pierre, Bauters, Anne, Stepanian, Alain, Cozzi, Maria R., Sveshnikova, Anastasia N., Faille, Dorothée, Hollon, Wendy, Chitlur, Meera, Casonato, Alessandra, Lasne, Dominique, Lavenu-Bombled, Cécile, Fiore, Mathieu, Hamidou, Bello, Hurtaud-Roux, Marie-Francoise, Saultier, Paul, Goumidi, Louisa, Gresele, Paolo, and Lordkipanidzé, Marie

Published
2023
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11. Guidelines for the prescription of standard hematology and biochemistry clinical laboratory tests in the intensive care unit: A scoping review protocol.

Author

Devis, Luigi L., Catry, Emilie, Hardy, Michael, Mansour, Alexandre, Honore, Patrick M., Lippi, Giuseppe, Closset, Mélanie, and Mullier, François

Subjects
GREY literature, CLINICAL biochemistry, PATIENTS' rights, KEYWORD searching, PATHOLOGICAL laboratories
Abstract

Objective: This scoping review protocol describes the strategy for a scoping review that aims to provide a comprehensive overview of published guidelines for the prescription of standard laboratory tests performed in intensive care unit (ICU) patients. Background: The use of clinical laboratories is constantly increasing. However, there is evidence of inappropriate use. Inappropriate laboratory testing has the potential to harm patients, increase costs, burden staff, and has an environmental impact. Effective management can be achieved through demand managing strategies, such as providing guidelines on performing the appropriate test, for the right patient, at the right time. Although national and international guidelines exist for individual tests, a comprehensive summary of available recommendations for laboratory testing in the ICU is currently unavailable. Inclusion criteria: This scoping review will incorporate documents that provide explicit advice on which test to perform in ICU patients. We selected 34 tests routinely ordered in the ICU. This review will consider any document type that matches our concept and context. We will consider gray literature with appropriate adherence to guidelines methodology. We will not limit the review by geographical location, but will only include articles published in English. Search strategy: Our scoping review will follow the Joanna Brigg Institute (JBI) methodology. We will search Medline (PubMed), Embase, Scopus, Google Scholar, and Google. Our search strategy adheres to the JBI 3-step construction approach for systematic reviews. We will search for keywords related to guidelines, laboratory testing, and the 34 selected tests. We will report our study using the S1 Checklist. Review registration number: osf.io/yfs9z. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Multicentre evaluation of 5B9, a monoclonal anti‐PF4/heparin IgG mimicking human HIT antibodies, as an internal quality control in HIT functional assays: Communication from the ISTH SSC Subcommittee on Platelet Immunology

Author

Pouplard, Claire, Rollin, Jérôme, Vayne, Caroline, Charuel, Noémie, Ahmadi, Zohra, Alberio, Lorenzo, Azjenberg, Nadine, Althaus, Karina, Bakchoul, Tamam, Chong, Beng, Curtis, Brian R., Faille, Dorothée, Gomez, Francisco‐Javier, Gresele, Paolo, Morel‐Kopp, Marie‐Christine, Mullier, François, Nazy, Izhac, Smith, James W., Greinacher, Andreas, and Gruel, Yves

Published
2022
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15. Heparin‐induced thrombocytopenia: Construction of a pretest diagnostic score derived from the analysis of a prospective multinational database, with internal validation

Author

Tardy‐Poncet, Brigitte, de Maistre, Emmanuel, Pouplard, Claire, Presles, Emilie, Alhenc‐Gelas, Martine, Lasne, Dominique, Horellou, Marie‐Hélène, Mouton, Christine, Serre‐Sapin, Anne, Bauters, Anne, Nguyen, Philippe, Mullier, François, Perrin, Julien, Le Gal, Grégoire, Morange, Pierre‐Emmanuel, Grunebaum, Lélia, Lillo‐Le Louet, Agnès, Elalamy, Ismail, Gruel, Yves, Greinacher, Andreas, Lecompte, Thomas, and Tardy, Bernard

Published
2021
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16. Diagnosis and management of heparin-induced thrombocytopenia

Author

Albaladejo, P., Belisle, S., Blais, N., Bonhomme, F., Borel-Derlon, A., Borg, J.Y., Bosson, J.-L., Cohen, A., Collet, J.-P., de Maistre, E., Faraoni, D., Fontana, P., Huet, D. Garrigue, Godier, A., Gruel, Y., Guay, J., Hardy, J.F., Huet, Y., Ickx, B., Laporte, S., Lasne, D., Levy, J.H., Llau, J., Le Gal, G., Lecompte, T., Lessire, S., Longrois, D., Madi-Jebara, S., Marret, E., Mas, J.L., Mazighi, M., Meyer, G., Mismetti, P., Morange, P.E., Motte, S., Mullier, F., Nathan, N., Nguyen, P., Ozier, Y., Pernod, G., Rosencher, N., Roullet, S., Roy, P.M., Samama, C.M., Schlumberger, S., Schved, J.F., Sié, P., Steib, A., Susen, S., Testa, S., van Belle, E., van Der Linden, P., Vincentelli, A., Zufferey, P., Gruel, Yves, De Maistre, Emmanuel, Pouplard, Claire, Mullier, François, Susen, Sophie, Roullet, Stéphanie, Blais, Normand, Le Gal, Grégoire, Vincentelli, André, Lasne, Dominique, Lecompte, Thomas, Albaladejo, Pierre, and Godier, Anne

Published
2020
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19. EVpedia: a community web portal for extracellular vesicles research

Author

Kim, Dae-Kyum, Lee, Jaewook, Kim, Sae Rom, Choi, Dong-Sic, Yoon, Yae Jin, Kim, Ji Hyun, Go, Gyeongyun, Nhung, Dinh, Hong, Kahye, Jang, Su Chul, Kim, Si-Hyun, Park, Kyong-Su, Kim, Oh Youn, Park, Hyun Taek, Seo, Ji Hye, Aikawa, Elena, Baj-Krzyworzeka, Monika, van Balkom, Bas WM, Belting, Mattias, Blanc, Lionel, Bond, Vincent, Bongiovanni, Antonella, Borràs, Francesc E, Buée, Luc, Buzás, Edit I, Cheng, Lesley, Clayton, Aled, Cocucci, Emanuele, Dela Cruz, Charles S, Desiderio, Dominic M, Di Vizio, Dolores, Ekström, Karin, Falcon-Perez, Juan M, Gardiner, Chris, Giebel, Bernd, Greening, David W, Gross, Julia Christina, Gupta, Dwijendra, Hendrix, An, Hill, Andrew F, Hill, Michelle M, Nolte-'t Hoen, Esther, Hwang, Do Won, Inal, Jameel, Jagannadham, Medicharla V, Jayachandran, Muthuvel, Jee, Young-Koo, Jørgensen, Malene, Kim, Kwang Pyo, Kim, Yoon-Keun, Kislinger, Thomas, Lässer, Cecilia, Lee, Dong Soo, Lee, Hakmo, van Leeuwen, Johannes, Lener, Thomas, Liu, Ming-Lin, Lötvall, Jan, Marcilla, Antonio, Mathivanan, Suresh, Möller, Andreas, Morhayim, Jess, Mullier, François, Nazarenko, Irina, Nieuwland, Rienk, Nunes, Diana N, Pang, Ken, Park, Jaesung, Patel, Tushar, Pocsfalvi, Gabriella, Del Portillo, Hernando, Putz, Ulrich, Ramirez, Marcel I, Rodrigues, Marcio L, Roh, Tae-Young, Royo, Felix, Sahoo, Susmita, Schiffelers, Raymond, Sharma, Shivani, Siljander, Pia, Simpson, Richard J, Soekmadji, Carolina, Stahl, Philip, Stensballe, Allan, Stępień, Ewa, Tahara, Hidetoshi, Trummer, Arne, Valadi, Hadi, Vella, Laura J, Wai, Sun Nyunt, Witwer, Kenneth, Yáñez-Mó, María, Youn, Hyewon, Zeidler, Reinhard, and Gho, Yong Song

Subjects
Biomedical Research, Computational Biology, Database Management Systems, Databases, Factual, Exosomes, Extracellular Space, Humans, Software, User-Computer Interface, Mathematical Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

MotivationExtracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging.ResultsWe present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.Availability and implementationThe web site was implemented in PHP, Java, MySQL and Apache, and is freely available at http://evpedia.info.

Published
2015

27. Position du GIHP sur les tests viscoélastiques : quelle place pour quelle indication en situation hémorragique ?

Author

Albaladejo, Pierre, Belisle, Sylvain, Blais, Normand, Bonhomme, Fanny, Borel-Derlon, Annie, Borg, Jeanne-Yvonne, Bosson, Jean-Luc, Cohen, Ariel, Collet, Jean-Philippe, de Maistre, Emmanuel, Faraoni, David, Fontana, Pierre, Garrigue Huet, Delphine, Godier, Anne, Gruel, Yves, Guay, Joanne, Hardy, Jean-François, Huet, Yann, Ickx, Brigitte, Laporte, Silvy, Lasne, Dominique, Levy, Jerrold H., Llau, Juan, Le Gal, Grégoire, Lecompte, Thomas, Lessire, Sarah, Longrois, Dan, Madi-Jebara, Samia, Marret, Emmanuel, Mas, Jean-Louis, Mazighi, Mikael, Mismetti, Patrick, Morange, Pierre-Emmanuel, Motte, Serge, Mullier, François, Nathan, Nathalie, Nguyen, Philippe, Ozier, Yves, Pernod, Gilles, Rosencher, Nadia, Roullet, Stéphanie, Roy, Pierre-Marie, Samama, Charles Marc, Schlumberger, Sylvie, Schved, Jean-François, Sié, Pierre, Steib, Annick, Susen, Sophie, van Belle, Eric, Van der Linden, Philippe, Vincentelli, André, Zufferey, Paul, and Garrigue, Delphine

Published
2018
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30. Serial fibrin monomer and D-dimer plasma levels measurements can capture thrombotic complications in critically ill COVID-19 patients: A prospective observational study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Services des soins intensifs, UCL - (MGD) Service de chirurgie cardio-vasculaire et thoracique, UCL - (MGD) Laboratoire de biologie clinique, Hardy, Michaël, Michaux, Isabelle, Bulpa, Pierre, Schonau, Benjamin, Nicolay, Benoit, de Maistre, E, Godon, A, Lecompte, T, Mullier, François, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Services des soins intensifs, UCL - (MGD) Service de chirurgie cardio-vasculaire et thoracique, UCL - (MGD) Laboratoire de biologie clinique, Hardy, Michaël, Michaux, Isabelle, Bulpa, Pierre, Schonau, Benjamin, Nicolay, Benoit, de Maistre, E, Godon, A, Lecompte, T, and Mullier, François

Published
2023

31. Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. 2022, , 860.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, Bareille, Marion, Lecompte, Thomas, Mullier, François, Roullet, Stéphanie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Laboratoire de biologie clinique, Bareille, Marion, Lecompte, Thomas, Mullier, François, and Roullet, Stéphanie

Abstract

With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use cartridge reagents allowing for their use by people without special laboratory skills, the appreciation of the actual clinical value of VHAs in settings such as severe trauma, post-partum hemorrhage, cardiac surgery and liver transplantation still needs to be fully validated. While two of the newest versions remain based on a 'cup and pin' system (ROTEM sigma, ClotPro), two other new devices (TEG 6s, Quantra) rely on very different technologies: clotting blood is no longer in contact with the probe and challenged by oscillation of one of the components but explored with ultrasound exposure. A systematic literature search (including Sonoclot) retrieved 20 observational studies (19 prospective). Most studies pointed to imperfect agreements, highlighting the non-interchangeability of devices. Only a few studies, often with a limited number of patients enrolled, used a clinical outcome. No study compared VHA results with conventional laboratory assays obtained through a rapid tests panel. Clinical evidence of the utility of the new VHAs largely remains to be proven through randomized clinical trials, with clinically relevant outcomes, and compared to rapid panel hemostasis testing. The availability of new, improved VHA devices provides an impetus and an opportunity to do so.

Published
2023

35. D-dimer testing: A narrative review

Author

Wauthier, L, Favresse, J, Hardy, Michaël, Douxfils, J, Le Gal, G, Roy, P M, van Es, N, Ay, C, Ten Cate, H, Lecompte, T, Lippi, G, Mullier, François, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Laboratoire de biologie clinique

Subjects
Postanalytic, Testing, COVID-19, Thrombosis, Venous Thromboembolism, Disseminated intravascular coagulation, Acute aortic syndrome (AAS), Analytic, D-dimer, Testing, Thrombosis, Fibrin Fibrinogen Degradation Products, Pregnancy, Preanalytic, D-dimer, Humans, Female, Blood Coagulation Tests, Cancer
Abstract

D-dimer containing species are soluble fibrin degradation products derived from plasmin-mediated degradation of cross-linked fibrin, i.e., 'D-dimer'. D-dimer can hence be considered a biomarker of in vivo activation of both coagulation and fibrinolysis, the leading clinical application in daily practice of which is ruling out venous thromboembolism (VTE). D-dimer has been further evaluated for assessing the risk of VTE recurrence and helping define optimal duration of anticoagulation treatment in VTE, for diagnosing disseminated intravascular coagulation (DIC), and for screening those at enhanced risk of VTE. D-dimer assays should however be performed as intended by regulatory agencies, as their use outside these indications might make them a laboratory-developed test (LDT). This narrative review is aimed at: (1) reviewing the definition of D-dimer, (2) discussing preanalytical variables affecting D-dimer measurement, (3) reviewing and comparing the assays performance and some postanalytical variables (e.g., different units and age-adjusted cutoffs), and (4) discussing the interest of D-dimer measurement across different clinical settings, including pregnancy, cancer, and coronavirus disease 2019 (COVID-19).

Published
2023

36. Multi-center evaluation of light transmission platelet aggregation reagents: Communication from the ISTH SSC Subcommittee on Platelet Physiology

Author

Alessi, Marie-Christine, Coxon, Carmen, Ibrahim-Kosta, Manal, Bacci, Monica, Voisin, Sophie, Rivera, José, Greinacher, Andreas, Raster, Johannes, Pulcinelli, Fabio, Devreese, Katrien Mj, Mullier, François, McCormick, Aine N, Frontroth, Juan Pablo, Pouplard, Claire, Sachs, Ulrich J, Diaz, Isabelle, Bermejo, Nuria, Camera, Marina, Fontana, Pierre, Bauters, Anne, Stepanian, Alain, Cozzi, Maria R, Sveshnikova, Anastasia N, Faille, Dorothée, Hollon, Wendy, Chitlur, Meera, Casonato, Alessandra, Lasne, Dominique, Lavenu-Bombled, Cécile, Fiore, Mathieu, Hamidou, Bello, Hurtaud-Roux, Marie-Francoise, Saultier, Paul, Goumidi, Louisa, Gresele, Paolo, Lordkipanidzé, Marie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Laboratoire de biologie clinique

Subjects
standardization, activators, multi-center, platelets, aggregation
Abstract

Light transmission aggregation (LTA) is used widely by the clinical and research communities. While it is a gold standard, there is a lack of inter-laboratory harmonization. The primary objective was to assess whether sources of activators (mainly Adenosine diphosphate (ADP), Collagen, Arachidonic acid, Epinephrine, Thrombin Receptor Activating Peptide (TRAP)6) and ristocetin contribute to poor LTA reproducibility. The secondary objective was to evaluate interindividual variability of results to appreciate the distribution of normal values and consequently better interpret pathological results. International multi-center study involving 28 laboratories in which we compared LTA results obtained with center-specific activators and a comparator which we supplied. We report a variability in the potency (P) of activators in comparison to the comparator. TRAP6 (P:1.32-2.68), arachidonic acid (P:0.87-1.43) and epinephrine (P:0.97-1.34) showed the greatest variability. ADP (P:1.04-1.20) and ristocetin (P:0.98-1.07) were the most consistent. The data highlighted clear interindividual variability notably for ADP and epinephrine. Four profiles of response were observed with ADP from high responders, intermediate responders and low responders. A fifth profile corresponding to non-responders (5% of the individuals) was observed with epinephrine. On the basis of these data, the establishment and adoption of simple standardization principles should mitigate variability due to activator sources. The observation of huge interindividual variability for certain concentrations of activators should lead to a cautious interpretation before reporting a result as abnormal. Confidence can be taken from the fact that difference between sources is not exacerbated in patients treated with antiplatelet agents.

Published
2023

37. Are Viscoelastometric Assays of Old Generation Ready for Disposal? Comment on Volod et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. 2022, , 860

Author

Bareille, Marion, Lecompte, Thomas, Mullier, François, Roullet, Stéphanie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Laboratoire de biologie clinique

Subjects
viscoelastometry, trauma, liver transplantation, postpartum hemorrhage, COVID-19, thromboelastography, fibrinogen, rotational thromboelastometry, viscoelastic testing, cardiac surgery, coagulopathy
Abstract

With the advent of new viscoelastometric hemostatic assay (VHA) devices, with ready-to-use cartridge reagents allowing for their use by people without special laboratory skills, the appreciation of the actual clinical value of VHAs in settings such as severe trauma, post-partum hemorrhage, cardiac surgery and liver transplantation still needs to be fully validated. While two of the newest versions remain based on a 'cup and pin' system (ROTEM sigma, ClotPro), two other new devices (TEG 6s, Quantra) rely on very different technologies: clotting blood is no longer in contact with the probe and challenged by oscillation of one of the components but explored with ultrasound exposure. A systematic literature search (including Sonoclot) retrieved 20 observational studies (19 prospective). Most studies pointed to imperfect agreements, highlighting the non-interchangeability of devices. Only a few studies, often with a limited number of patients enrolled, used a clinical outcome. No study compared VHA results with conventional laboratory assays obtained through a rapid tests panel. Clinical evidence of the utility of the new VHAs largely remains to be proven through randomized clinical trials, with clinically relevant outcomes, and compared to rapid panel hemostasis testing. The availability of new, improved VHA devices provides an impetus and an opportunity to do so.

Published
2023

40. Assessment of DOAC in GEriatrics (Adage Study): Rivaroxaban/Apixaban Concentrations and Thrombin Generation Profiles in NVAF Very Elderly Patients

Author

Foulon-Pinto, Geoffrey, additional, Lafuente-Lafuente, Carmelo, additional, Jourdi, Georges, additional, Guen, Julien Le, additional, Tall, Fatoumata, additional, Puymirat, Etienne, additional, Delrue, Maxime, additional, Rivière, Léa, additional, Ketz, Flora, additional, Gouin-Thibault, Isabelle, additional, Mullier, François, additional, Gaussem, Pascale, additional, Pautas, Eric, additional, Lecompte, Thomas, additional, Curis, Emmanuel, additional, and Siguret, Virginie, additional

Published
2022
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41. D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review

Author

Wauthier, Loris, primary, Favresse, Julien, additional, Hardy, Michaël, additional, Douxfils, Jonathan, additional, Le Gal, Grégoire, additional, Roy, Pierre-Marie, additional, van Es, Nick, additional, Ay, Cihan, additional, ten Cate, Hugo, additional, Vander Borght, Thierry, additional, Dupont, Michaël V., additional, Lecompte, Thomas, additional, Lippi, Giuseppe, additional, and Mullier, François, additional

Published
2022
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