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Cyclometallated compounds have been extensively studied, in particular those with palladium and platinum. This is because of their possible applications in medicinal chemistry, as anticancer or antimicrobial agents; in some cases, with similar results as cisplatin, carboplatin or oxaliplatin. What is also remarkable is their use as homogeneous catalysts, for example, in cross coupling reactions such as Suzuki–Miyaura or Mizoroki–Heck. Herein, we report the synthesis of different thiosemicarbazone ligands, which will be reacted with a palladium or platinum salt, to give the corresponding cyclometallated compounds; in addition, their reactivity with bis(diphenylphosphino)methane (dppm) will be studied. Characterization has been carried out by elemental analysis, IR spectroscopy, 1H and 31P NMR spectroscopy. Additionally, 1c has been studied by X-ray diffraction

Se han estudiado la síntesis de tres familias de compuestos ciclometalados conteniendo diferentes grupos funcionales así como su reactividad frente a diferentes ligandos con el fin de obtener compuestos ciclometalados con propiedades interesantes en diferentes campos de investigación como pueden ser los procesos de catálisis o la biomedicina. Se ha conseguido describir con detalla el proceso para la síntesis de estructuras tipo A‐frame dobles derivadas de compuestos del tipo bases de Schiff.

[Abstract] Palladacycles of the type [Pd2(Ph2PCH2PPh2-P,P)2(C,N:C,N)] (C,N:C,N = bis(N-2,3,4-trimethoxybenzylidene)-4,4′-sulfonyldianiline or -4,4′-oxydianiline) can undergo a spontaneous slow chelate-to-bridging diphosphane coordination shift in solution. Following this strategy a tailor-made synthetic procedure was devised that culminates in isolation of double A-frame tetranuclear palladium complexes.

Thiosemicarbazones are well known compounds that show antitumoral and antibacterial proprieties[1] ; while crown ether moiety acts as ion sensor to entrap cations size-selectively from the environment, implied in the production of sensors, membrane ion transport or potential anti-cancerous species, among others[2]. The combination of both functions into the same molecule should increase their unique applications. Herein we report on the synthesis of a molecule that combines both functions. The main aspect is that the study has being performed beginning with the design of the compound using DFT calculations, with the package of programs g09[3], after which follows the final synthesis and characterization using 1H NMR, IR and crystallographic analysis

The purpose of this work is the design, synthesis and characterization of thiosemicarbazone ligands bearing a phenyl boronic acid functionality. The main interest is the synthesis of organopalladium compounds with the boronic acid included within the corresponding molecule. These could lead to further modification of the properties of the organometallic species applicable to the Suzuki-Miyaura reaction. The ligands were prepared by reaction of acetylphenylboronic acid with several thiosemicarbazides. The compounds were characterized by IR, 1H and 31P NMR spectroscopy

Thiosemicarbazones are formed by the condensation of an aldehyde or ketone with a thiosemicarbazide. They have high coordinative capacity given that they have several potential donor atoms through which they can bind to transition metals. This coordinative capacity can be increased if the R1 and R2 substituents include additional donor atoms. In addition, thiosemicarbazones as well as their semicarbazones analogues have considerable biological and pharmacological interest because of their antibacterial, antiviral and antitumor activity. This communication includes the preparation and characterization of a series of thiosemicarcarbazones and their applications in the synthesis of palladium organometallic compounds