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81 results on '"Muñoz-Canoves, Pura"'

1. Network-community analysis of cellular senescence

Author

Sabalic, Alda, Moiseeva, Victoria, Cisneros, Andres, Deryagin, Oleg, Perdiguero, Eusebio, Muñoz-Canoves, Pura, and Garcia-Ojalvo, Jordi

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Most cellular phenotypes are genetically complex. Identifying the set of genes that are most closely associated with a specific cellular state is still an open question in many cases. Here we study the transcriptional profile of cellular senescence using a combination of network-based approaches, which include eigenvector centrality feature selection and community detection. We apply our method to cell-type-resolved RNA sequencing data obtained from injured muscle tissue in mice. The analysis identifies some genetic markers consistent with previous findings, and other previously unidentified ones, which are validated with previously published single-cell RNA sequencing data in a different type of tissue. The key identified genes, both those previously known and the newly identified ones, are transcriptional targets of factors known to be associated with established hallmarks of senescence, and can thus be interpreted as molecular correlates of such hallmarks. The method proposed here could be applied to any complex cellular phenotype even when only bulk RNA sequencing is available, provided the data is resolved by cell type., Comment: 20 pages, 11 figures

Published
2024

3. The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

Author

Mortimer, Thomas, Zinna, Valentina M., Atalay, Muge, Laudanna, Carmelo, Deryagin, Oleg, Posas, Guillem, Smith, Jacob G., García-Lara, Elisa, Vaca-Dempere, Mireia, Monteiro de Assis, Leonardo Vinícius, Heyde, Isabel, Koronowski, Kevin B., Petrus, Paul, Greco, Carolina M., Forrow, Stephen, Oster, Henrik, Sassone-Corsi, Paolo, Welz, Patrick-Simon, Muñoz-Cánoves, Pura, and Benitah, Salvador Aznar

Published
2024
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5. Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

Author

Smith, Jacob G., Koronowski, Kevin B., Mortimer, Thomas, Sato, Tomoki, Greco, Carolina M., Petrus, Paul, Verlande, Amandine, Chen, Siwei, Samad, Muntaha, Deyneka, Ekaterina, Mathur, Lavina, Blazev, Ronnie, Molendijk, Jeffrey, Kumar, Arun, Deryagin, Oleg, Vaca-Dempere, Mireia, Sica, Valentina, Liu, Peng, Orlando, Valerio, Parker, Benjamin L., Baldi, Pierre, Welz, Patrick-Simon, Jang, Cholsoon, Masri, Selma, Benitah, Salvador Aznar, Muñoz-Cánoves, Pura, and Sassone-Corsi, Paolo

Published
2023
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6. Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling

Author

Feng, Xuesong, Wang, A. Hongjun, Juan, Aster H., Ko, Kyung Dae, Jiang, Kan, Riparini, Giulia, Ciuffoli, Veronica, Kaba, Aissah, Lopez, Christopher, Naz, Faiza, Jarnik, Michal, Aliberti, Elizabeth, Hu, Shenyuan, Segalés, Jessica, Khateb, Mamduh, Acevedo-Luna, Natalia, Randazzo, Davide, Cheung, Tom H., Muñoz-Cánoves, Pura, Dell’Orso, Stefania, and Sartorelli, Vittorio

Published
2023
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8. Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

Author

Hong, Xiaotong, Isern, Joan, Campanario, Silvia, Perdiguero, Eusebio, Ramírez-Pardo, Ignacio, Segalés, Jessica, Hernansanz-Agustín, Pablo, Curtabbi, Andrea, Deryagin, Oleg, Pollán, Angela, González-Reyes, José A., Villalba, José M., Sandri, Marco, Serrano, Antonio L., Enríquez, José A., and Muñoz-Cánoves, Pura

Published
2022
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9. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

Author

Chen, Ao, Liao, Sha, Cheng, Mengnan, Ma, Kailong, Wu, Liang, Lai, Yiwei, Qiu, Xiaojie, Yang, Jin, Xu, Jiangshan, Hao, Shijie, Wang, Xin, Lu, Huifang, Chen, Xi, Liu, Xing, Huang, Xin, Li, Zhao, Hong, Yan, Jiang, Yujia, Peng, Jian, Liu, Shuai, Shen, Mengzhe, Liu, Chuanyu, Li, Quanshui, Yuan, Yue, Wei, Xiaoyu, Zheng, Huiwen, Feng, Weimin, Wang, Zhifeng, Liu, Yang, Wang, Zhaohui, Yang, Yunzhi, Xiang, Haitao, Han, Lei, Qin, Baoming, Guo, Pengcheng, Lai, Guangyao, Muñoz-Cánoves, Pura, Maxwell, Patrick H., Thiery, Jean Paul, Wu, Qing-Feng, Zhao, Fuxiang, Chen, Bichao, Li, Mei, Dai, Xi, Wang, Shuai, Kuang, Haoyan, Hui, Junhou, Wang, Liqun, Fei, Ji-Feng, Wang, Ou, Wei, Xiaofeng, Lu, Haorong, Wang, Bo, Liu, Shiping, Gu, Ying, Ni, Ming, Zhang, Wenwei, Mu, Feng, Yin, Ye, Yang, Huanming, Lisby, Michael, Cornall, Richard J., Mulder, Jan, Uhlén, Mathias, Esteban, Miguel A., Li, Yuxiang, Liu, Longqi, Xu, Xun, and Wang, Jian

Published
2022
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12. A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Author

Nicolás-Ávila, José A., Lechuga-Vieco, Ana V., Esteban-Martínez, Lorena, Sánchez-Díaz, María, Díaz-García, Elena, Santiago, Demetrio J., Rubio-Ponce, Andrea, Li, Jackson LiangYao, Balachander, Akhila, Quintana, Juan A., Martínez-de-Mena, Raquel, Castejón-Vega, Beatriz, Pun-García, Andrés, Través, Paqui G., Bonzón-Kulichenko, Elena, García-Marqués, Fernando, Cussó, Lorena, A-González, Noelia, González-Guerra, Andrés, Roche-Molina, Marta, Martin-Salamanca, Sandra, Crainiciuc, Georgiana, Guzmán, Gabriela, Larrazabal, Jagoba, Herrero-Galán, Elías, Alegre-Cebollada, Jorge, Lemke, Greg, Rothlin, Carla V., Jimenez-Borreguero, Luis Jesús, Reyes, Guillermo, Castrillo, Antonio, Desco, Manuel, Muñoz-Cánoves, Pura, Ibáñez, Borja, Torres, Miguel, Ng, Lai Guan, Priori, Silvia G., Bueno, Héctor, Vázquez, Jesús, Cordero, Mario D., Bernal, Juan A., Enríquez, José A., and Hidalgo, Andrés

Published
2020
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15. Longevity biotechnology:bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Author

Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Bakula, Daniela, Lyu, Yu Xuan, Fu, Qiang, Wilczok, Dominika, Ying, Kejun, King, Aaron, Antebi, Adam, Vojta, Aleksandar, Stolzing, Alexandra, Moskalev, Alexey, Georgievskaya, Anastasia, Maier, Andrea B., Olsen, Andrea, Groth, Anja, Simon, Anna Katharina, Brunet, Anne, Jamil, Aisyah, Kulaga, Anton, Bhatti, Asif, Yaden, Benjamin, Pedersen, Bente Klarlund, Schumacher, Björn, Djordjevic, Boris, Kennedy, Brian, Chen, Chieh, Huang, Christine Yuan, Correll, Christoph U., Murphy, Coleen T., Ewald, Collin Y., Chen, Danica, Valenzano, Dario Riccardo, Sołdacki, Dariusz, Erritzoe, David, Meyer, David, Sinclair, David A., Chini, Eduardo Nunes, Teeling, Emma C., Morgen, Eric, Verdin, Eric, Vernet, Erik, Pinilla, Estefano, Fang, Evandro F., Bischof, Evelyne, Mercken, Evi M., Finger, Fabian, Kuipers, Folkert, Pun, Frank W., Gyülveszi, Gabor, Civiletto, Gabriele, Zmudze, Garri, Blander, Gil, Pincus, Harold A., McClure, Joshua, Kirkland, James L., Peyer, James, Justice, Jamie N., Vijg, Jan, Gruhn, Jennifer R., McLaughlin, Jerry, Mannick, Joan, Passos, João, Baur, Joseph A., Betts-LaCroix, Joe, Sedivy, John M., Speakman, John R., Shlain, Jordan, von Maltzahn, Julia, Andreasson, Katrin I., Moody, Kelsey, Palikaras, Konstantinos, Fortney, Kristen, Niedernhofer, Laura J., Rasmussen, Lene Juel, Veenhoff, Liesbeth M., Melton, Lisa, Ferrucci, Luigi, Quarta, Marco, Koval, Maria, Marinova, Maria, Hamalainen, Mark, Unfried, Maximilian, Ringel, Michael S., Filipovic, Milos, Topors, Mourad, Mitin, Natalia, Roy, Nawal, Pintar, Nika, Barzilai, Nir, Binetti, Paolo, Singh, Parminder, Kohlhaas, Paul, Robbins, Paul D., Rubin, Paul, Fedichev, Peter O., Kamya, Petrina, Muñoz-Canoves, Pura, Cabo, Rafael de, Faragher, Richard G.A., Konrad, Rob, Ripa, Roberto, Mansukhani, Robin, Büttner, Sabrina, Wickström, Sara A., Brunemeier, Sebastian, Jakimov, Sergey, Luo, Shan, Rosenzweig-Lipson, Sharon, Tsai, Shih Yin, Dimmeler, Stefanie, Rando, Thomas A., Peterson, Tim R., Woods, Tina, Wyss-Coray, Tony, Finkel, Toren, Strauss, Tzipora, Gladyshev, Vadim N., Longo, Valter D., Dwaraka, Varun B., Gorbunova, Vera, Acosta-Rodríguez, Victoria A., Sorrentino, Vincenzo, Sebastiano, Vittorio, Li, Wenbin, Suh, Yousin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, and Bakula, Daniela

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Published
2024

24. The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

Author

Gómez-del Arco, Pablo, Perdiguero, Eusebio, Yunes-Leites, Paula Sofia, Acín-Pérez, Rebeca, Zeini, Miriam, Garcia-Gomez, Antonio, Sreenivasan, Krishnamoorthy, Jiménez-Alcázar, Miguel, Segalés, Jessica, López-Maderuelo, Dolores, Ornés, Beatriz, Jiménez-Borreguero, Luis Jesús, D’Amato, Gaetano, Enshell-Seijffers, David, Morgan, Bruce, Georgopoulos, Katia, Islam, Abul B.M.M.K., Braun, Thomas, de la Pompa, José Luis, Kim, Johnny, Enriquez, José A., Ballestar, Esteban, Muñoz-Cánoves, Pura, and Redondo, Juan Miguel

Published
2016
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29. uPA Deficiency Exacerbates Muscular Dystrophy in MDX Mice

Author

Suelves, Mònica, Vidal, Berta, Serrano, Antonio L., Tjwa, Marc, Roma, Josep, López-Alemany, Roser, Luttun, Aernout, de Lagrán, María Martínez, Àngels Díaz, Maria, Jardí, Mercè, Roig, Manuel, Dierssen, Mara, Dewerchin, Mieke, Carmeliet, Peter, and Muñoz-Cánoves, Pura

Published
2007
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45. 240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25–27 January 2019, Hoofddorp, The Netherlands

Author

Amthor, Helge, Birchmeier, Carmen, Bonaldo, Paolo, Bönnemann, Carsten, Browne, Gillian Butler, Chaturvedi, Dhananjay, Davenport, Richard, Ferreiro, Ana, Furling, Denis, Giordani, Lorenzo, Grounds, Miranda, Jungbluth, Heinz, Muñoz-Cánoves, Pura, Mishra, Prasant, Morgan, Jennifer, Muntoni, Francesco, Padberg, George, Paradas, Carmen, Partridge, Terry, Patel, Ketan, Relaix, Frederic, Rüegg, Markus, Stevenson, Alison, Van Putten, Maaike, Wood, Alasdair, Zammit, Peter, and Butler-Browne, Gillian

Published
2019
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50. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.

Author

Cuadrado, Ana, Corrado, Nadia, Perdiguero, Eusebio, Lafarga, Vanesa, Muñoz-Canoves, Pura, and Nebreda, Angel R.

Subjects
CHROMATIN, YEAST, HISTONES, GENE expression, GENETIC regulation
Abstract

The chromatin-remodelling complex SNF2-related CBP activator protein (SRCAP) regulates chromatin structure in yeast by modulating the exchange of histone H2A for the H2A.Z variant. Here, we have investigated the contribution of H2A.Z-mediated chromatin remodelling to mammalian cell differentiation reprogramming. We show that the SRCAP subunit named ZNHIT1 or p18Hamlet, which is a substrate of p38 MAPK, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 MAPK-dependent manner. We also show that p18Hamlet is required for H2A.Z accumulation into this genomic region and for subsequent muscle gene transcriptional activation. Accordingly, downregulation of several subunits or the SRCAP complex impairs muscle gene expression. These results identify SRCAP/H2A.Z-mediated chromatin remodelling as a key early event in muscle differentiation-specific gene expression. We also propose a mechanism by which p38 MAPK-mediated signals are converted into chromatin structural changes, thereby facilitating transcriptional activation during mammalian cell differentiation. [ABSTRACT FROM AUTHOR]

Published
2010
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