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1. Overview of CAPICE—Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe—an EU Marie Skłodowska-Curie International Training Network

Author

Rajula, H.S.R. (Hema Sekhar Reddy), Manchia, M. (Mriko), Agarwal, K. (Kratika), Akingbuwa, W.A. (Wonuola A.), Allegrini, A.G. (Andrea G.), Diemer, E. (Elizabeth), Doering, S. (Sabrina), Haan, E. (Elis), Jami, E.S. (Eshim S.), Karhunen, V. (Ville), Leone, M. (Marica), Schellhas, L. (Laura), Thompson, A. (Ashley), Berg, S.M. (Stéphanie) van den, Bergen, S.E. (Sarah), Kuja-Halkola, R. (Ralf), Hammerschlag, A.R. (Anke R.), Järvelin, M.R. (Marjo Riitta), Leval, A. (Amy), Lichtenstein, P. (Paul), Lundstrom, S. (Sebastian), Mauri, M. (Matteo), Munafò, M.R. (Marcus), Myers, D. (David), Plomin, R. (Robert), Rimfeld, K. (Kaili), Tiemeier, H.W. (Henning), Ystrom, E. (Eivind), Fanos, V. (Vassilios), Bartels, M. (Meike), Middeldorp, C.M. (Christel M.), Rajula, H.S.R. (Hema Sekhar Reddy), Manchia, M. (Mriko), Agarwal, K. (Kratika), Akingbuwa, W.A. (Wonuola A.), Allegrini, A.G. (Andrea G.), Diemer, E. (Elizabeth), Doering, S. (Sabrina), Haan, E. (Elis), Jami, E.S. (Eshim S.), Karhunen, V. (Ville), Leone, M. (Marica), Schellhas, L. (Laura), Thompson, A. (Ashley), Berg, S.M. (Stéphanie) van den, Bergen, S.E. (Sarah), Kuja-Halkola, R. (Ralf), Hammerschlag, A.R. (Anke R.), Järvelin, M.R. (Marjo Riitta), Leval, A. (Amy), Lichtenstein, P. (Paul), Lundstrom, S. (Sebastian), Mauri, M. (Matteo), Munafò, M.R. (Marcus), Myers, D. (David), Plomin, R. (Robert), Rimfeld, K. (Kaili), Tiemeier, H.W. (Henning), Ystrom, E. (Eivind), Fanos, V. (Vassilios), Bartels, M. (Meike), and Middeldorp, C.M. (Christel M.)

Abstract

The Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER) identified child and adolescent mental illness as a priority area for research. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) is a European Union (EU) funded training network aimed at investigating the causes of individual differences in common childhood and adolescent psychopathology, especially depression, anxiety, and attention defici

Published
2021
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2. A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study

Author

Yücel, M. (Murat), Oldenhof, E. (Erin), Ahmed, S.H. (Serge H.), Belin, D. (David), Billieux, J. (Joel), Bowden-Jones, H. (Henrietta), Carter, A. (Adrian), Chamberlain, S.R. (Samuel R.), Clark, L. (Luke), Connor, J. (Jason), Daglish, M. (Mark), Dom, G. (Geert), Dannon, P. (Pinhas), Duka, T. (Theodora), Fernandez-Serrano, M.J. (Maria Jose), Field, M. (Matt), Franken, I.H.A. (Ingmar), Goldstein, R.Z. (Rita), Gonzalez, R. (Raul), Goudriaan, A.E. (Anna), Grant, J.E. (Jon E.), Gullo, M.J. (Matthew J.), Hester, R. (Rob), Hodgins, D.C. (David C.), Le Foll, B. (Bernard), Lee, R.S.C. (Rico S. C.), Lingford-Hughes, A. (Anne), Lorenzetti, V. (Valentina), Moeller, S.J. (Scott J.), Munafò, M.R. (Marcus), Odlaug, B. (Brian), Potenza, M.N. (Marc N.), Segrave, R. (Rebecca), Sjoerds, Z. (Zsuzsika), Solowij, N. (Nadia), Brink, W. (Wim) van den, Holst, R.J. (Ruth) van, Voon, V. (Valerie), Wiers, R.W. (Reinout), Fontenelle, L.F. (Leonardo F.), Verdejo-Garcia, A. (Antonio), Yücel, M. (Murat), Oldenhof, E. (Erin), Ahmed, S.H. (Serge H.), Belin, D. (David), Billieux, J. (Joel), Bowden-Jones, H. (Henrietta), Carter, A. (Adrian), Chamberlain, S.R. (Samuel R.), Clark, L. (Luke), Connor, J. (Jason), Daglish, M. (Mark), Dom, G. (Geert), Dannon, P. (Pinhas), Duka, T. (Theodora), Fernandez-Serrano, M.J. (Maria Jose), Field, M. (Matt), Franken, I.H.A. (Ingmar), Goldstein, R.Z. (Rita), Gonzalez, R. (Raul), Goudriaan, A.E. (Anna), Grant, J.E. (Jon E.), Gullo, M.J. (Matthew J.), Hester, R. (Rob), Hodgins, D.C. (David C.), Le Foll, B. (Bernard), Lee, R.S.C. (Rico S. C.), Lingford-Hughes, A. (Anne), Lorenzetti, V. (Valentina), Moeller, S.J. (Scott J.), Munafò, M.R. (Marcus), Odlaug, B. (Brian), Potenza, M.N. (Marc N.), Segrave, R. (Rebecca), Sjoerds, Z. (Zsuzsika), Solowij, N. (Nadia), Brink, W. (Wim) van den, Holst, R.J. (Ruth) van, Voon, V. (Valerie), Wiers, R.W. (Reinout), Fontenelle, L.F. (Leonardo F.), and Verdejo-Garcia, A. (Antonio)

Abstract

Background: The US National Institutes of Mental Health Research Domain Criteria (RDoC) seek to stimulate research into biologically validated neuropsychological dimensions across mental illness symptoms and diagnoses. The RDoC framework comprises 39 functional constructs designed to be revised and refined, with the overall goal of improving diagnostic validity and treatments. This study aimed to reach a consensus among experts in the addiction field on the ‘primary’ RDoC constructs most relevant to substance and behavioural addictions. Methods: Forty-four addiction experts were recruited from Australia, Asia, Europe and the Americas. The Delphi technique was used to determine a consensus as to the degree of importance of each construct in understanding the essential dimensions underpinning addictive behaviours. Expert opinions were canvassed online over three rounds (97% completion rate), with each consecutive round offering feedback for experts to review their opinions. Results: Seven constructs were endorsed by ≥ 80% of experts as ‘primary’ to the understanding of addictive behaviour: five from the Positive Valence System (reward valuation, expectancy, action selection, reward learning, habit); one from the Cognitive Control System (response selection/inhibition); and one expert-initiated construct (compulsivity). These constructs were rated to be related differentially to stages of the addiction cycle, with some linked more closely to addiction onset and others more to chronicity. Experts agreed that these neuropsychological dimensions apply across a range of addictions. Conclusions: The study offers a novel and neuropsychologically informed theoretical framework, as well as a cogent step forward to test transdiagnostic concepts in addiction research, with direct implications for assessment, diagnosis, staging of disorder, and treatment.

Published
2018
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3. Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: The CARTA consortium

Author

Taylor, A.E. (Amy E.), Fluharty, M.E. (Meg E.), Bjørngaard, J.H. (Johan H.), Gabrielsen, M.E. (Maiken Elvestad), Skorpen, F. (Frank), Marioni, R.E. (Riccardo), Campbell, A. (Archie), Engmann, J. (Jorgen), Mirza, S.S. (Saira), Loukola, A. (Anu), Laatikainen, T. (Tiina), Partonen, T. (Timo), Kaakinen, M. (Marika), Ducci, F. (Francesca), Cavadino, A. (Alana), Husemoen, L.L.N. (Lise Lotte), Ahluwalia, T.S. (Tarunveer Singh), Jacobsen, R.K. (Rikke Kart), Skaaby, T. (Tea), Ebstrup, J.F. (Jeanette Frost), Mortensen, E.L. (Erik), Minica, C.C. (Camelia C.), Vink, J.M. (Jacqueline), Willemsen, G.A.H.M. (Gonneke), Marques-Vidal, P. (Pedro), Dale, C.E. (Caroline E.), Amuzu, A. (Antoinette), Lennon, L.T. (Lucy T.), Lahti, J. (Jari), Palotie, A. (Aarno), Räikkönen, K. (Katri), Wong, A. (Andrew), Paternoster, L. (Lavinia), Wong, A.P.-Y. (Angelita Pui-Yee), Horwood, L.J. (L. John), Murphy, M. (Michael), Johnstone, E.C. (Elaine C.), Kennedy, M.A. (Martin A.), Pausova, Z. (Zdenka), Paus, T. (Tomáš), Ben-Shlomo, Y., Nohr, C. (Christian), Kuh, D. (Diana), Kivimaki, M. (Mika), Eriksson, J.G. (Johan G.), Morris, R.W. (Richard), Casas, J.P. (Juan), Preisig, M. (Martin), Boomsma, D.I. (Dorret), Linneberg, A. (Allan), Power, C. (Christopher), Hypponen, E. (Elina), Veijola, J. (Juha), Jarvelin, M.-R. (Marjo-Riitta), Korhonen, T. (Tellervo), Tiemeier, H.W. (Henning), Kumari, M. (Meena), Porteous, D.J. (David J.), Hayward, C. (Caroline), Romundstad, P.R. (Pa˚l R.), Smith, A.V. (Davey), Munafò, M.R. (Marcus), Taylor, A.E. (Amy E.), Fluharty, M.E. (Meg E.), Bjørngaard, J.H. (Johan H.), Gabrielsen, M.E. (Maiken Elvestad), Skorpen, F. (Frank), Marioni, R.E. (Riccardo), Campbell, A. (Archie), Engmann, J. (Jorgen), Mirza, S.S. (Saira), Loukola, A. (Anu), Laatikainen, T. (Tiina), Partonen, T. (Timo), Kaakinen, M. (Marika), Ducci, F. (Francesca), Cavadino, A. (Alana), Husemoen, L.L.N. (Lise Lotte), Ahluwalia, T.S. (Tarunveer Singh), Jacobsen, R.K. (Rikke Kart), Skaaby, T. (Tea), Ebstrup, J.F. (Jeanette Frost), Mortensen, E.L. (Erik), Minica, C.C. (Camelia C.), Vink, J.M. (Jacqueline), Willemsen, G.A.H.M. (Gonneke), Marques-Vidal, P. (Pedro), Dale, C.E. (Caroline E.), Amuzu, A. (Antoinette), Lennon, L.T. (Lucy T.), Lahti, J. (Jari), Palotie, A. (Aarno), Räikkönen, K. (Katri), Wong, A. (Andrew), Paternoster, L. (Lavinia), Wong, A.P.-Y. (Angelita Pui-Yee), Horwood, L.J. (L. John), Murphy, M. (Michael), Johnstone, E.C. (Elaine C.), Kennedy, M.A. (Martin A.), Pausova, Z. (Zdenka), Paus, T. (Tomáš), Ben-Shlomo, Y., Nohr, C. (Christian), Kuh, D. (Diana), Kivimaki, M. (Mika), Eriksson, J.G. (Johan G.), Morris, R.W. (Richard), Casas, J.P. (Juan), Preisig, M. (Martin), Boomsma, D.I. (Dorret), Linneberg, A. (Allan), Power, C. (Christopher), Hypponen, E. (Elina), Veijola, J. (Juha), Jarvelin, M.-R. (Marjo-Riitta), Korhonen, T. (Tellervo), Tiemeier, H.W. (Henning), Kumari, M. (Meena), Porteous, D.J. (David J.), Hayward, C. (Caroline), Romundstad, P.R. (Pa˚l R.), Smith, A.V. (Davey), and Munafò, M.R. (Marcus)

Abstract

Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. Participants: Current, former and never smokers of European ancestry aged ≥16 years from 25 studies in the Consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Binary definitions of depression, anxiety and psychological distress assessed by clinical interview, symptom scales or self-reported recall of clinician diagnosis. Results: The analytic sample included up to 58 176 never smokers, 37 428 former smokers and 32 028 current smokers (total N=127 632). In observational analyses, current smokers had 1.85 times greater odds of depression (95% CI 1.65 to 2.07), 1.71 times greater odds of anxiety (95% CI 1.54 to 1.90) and 1.69 times greater odds of psychological distress (95% CI 1.56 to 1.83) than never smokers. Former smokers also had greater odds of depression, anxiety and psychological distress than never smokers. There was evidence for positive associations of smoking heaviness with depression, anxiety and psychological distress (ORs per cigarette per day: 1.03 (95% CI 1.02 to 1.04), 1.03 (95% CI 1.02 to 1.04) and 1.02 (95% CI 1.02 to 1.03) respectively). In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers. Results were similar for former smokers. Conclusions: Findings from Mendelian randomisation analyses do not support a causal role of smoking heaviness in the develop

Published
2014
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4. Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

Author

Evans, D.M. (David), Brion, M.-J. (Maria), Paternoster, L. (Lavinia), Kemp, J.P. (John), Mcmahon, G. (George), Munafò, M.R. (Marcus), Whitfield, J. (John), Medland, S.E. (Sarah), Montgomery, G.W. (Grant), Timpson, N.J. (Nicholas), St Pourcain, B. (Beate), Lawlor, D.A. (Debbie), Martin, N.G. (Nicholas), Dehghan, A. (Abbas), Hirschhorn, J.N. (Joel), Davey-Smith, G. (George), Evans, D.M. (David), Brion, M.-J. (Maria), Paternoster, L. (Lavinia), Kemp, J.P. (John), Mcmahon, G. (George), Munafò, M.R. (Marcus), Whitfield, J. (John), Medland, S.E. (Sarah), Montgomery, G.W. (Grant), Timpson, N.J. (Nicholas), St Pourcain, B. (Beate), Lawlor, D.A. (Debbie), Martin, N.G. (Nicholas), Dehghan, A. (Abbas), Hirschhorn, J.N. (Joel), and Davey-Smith, G. (George)

Abstract

It is common practice in genome-wide association studies (GWAS) to focus on the relationship between disease risk and genetic variants one marker at a time. When relevant genes are identified it is often possible to implicate biological intermediates and pathways likely to be involved in disease aetiology. However, single genetic variants typically explain small amounts of disease risk. Our idea is to construct allelic scores that explain greater proportions of the variance in biological intermediates, and subsequently use these scores to data mine GWAS. To investigate the approach's properties, we indexed three biological intermediates where the results of large GWAS meta-analyses were available: bo

Published
2013
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