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2. Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas

Author

Mundo, Lucia, Del Porro, Leonardo, Granai, Massimo, Siciliano, Maria Chiara, Mancini, Virginia, Santi, Raffaella, Marcar, Lynnette, Vrzalikova, Katerina, Vergoni, Federica, Di Stefano, Gioia, Schiavoni, Gianluca, Segreto, Giovanna, Onyango, Noel, Nyagol, Joshua Akelo, Amato, Teresa, Bellan, Cristiana, Anagnostopoulos, Ioannis, Falini, Brunangelo, Leoncini, Lorenzo, Tiacci, Enrico, and Lazzi, Stefano

Published
2020
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3. Aflatoxin B1 and Epstein-Barr virus-induced CCL22 expression stimulates B cell infection.

Author

Maroui, Mohamed Ali, Odongo, Grace Akinyi, Mundo, Lucia, Manara, Francesca, Mure, Fabrice, Fusil, Floriane, Jay, Antonin, Gheit, Tarik, Michailidis, Thanos M., Ferrara, Domenico, Leoncini, Lorenzo, Murray, Paul, Manet, Evelyne, Ohlmann, Théophile, De Boevre, Marthe, De Saeger, Sarah, Cosset, François-Loïc, Lazzi, Stefano, Accardi, Rosita, and Herceg, Zdenko

Subjects
B cells, AFLATOXINS, NF-kappa B, VIRAL genes, ONCOGENIC viruses, NATURAL products, CURCUMIN
Abstract

Epstein-Barr Virus (EBV) infects more than 90% of the adult population worldwide. EBV infection is associated with Burkitt lymphoma (BL) though alone is not sufficient to induce carcinogenesis implying the involvement of co-factors. BL is endemic in African regions faced with mycotoxins exposure. Exposure to mycotoxins and oncogenic viruses has been shown to increase cancer risks partly through the deregulation of the immune response. A recent transcriptome profiling of B cells exposed to aflatoxin B1 (AFB1) revealed an upregulation of the Chemokine ligand 22 (CCL22) expression although the underlying mechanisms were not investigated. Here, we tested whether mycotoxins and EBV exposure may together contribute to endemic BL (eBL) carcinogenesis via immunomodulatory mechanisms involving CCL22. Our results revealed that B cells exposure to AFB1 and EBV synergistically stimulated CCL22 secretion via the activation of Nuclear Factor-kappa B pathway. By expressing EBV latent genes in B cells, we revealed that elevated levels of CCL22 result not only from the expression of the latent membrane protein LMP1 as previously reported but also from the expression of other viral latent genes. Importantly, CCL22 overexpression resulting from AFB1-exposure in vitro increased EBV infection through the activation of phosphoinositide-3-kinase pathway. Moreover, inhibiting CCL22 in vitro and in humanized mice in vivo limited EBV infection and decreased viral genes expression, supporting the notion that CCL22 overexpression plays an important role in B cell infection. These findings unravel new mechanisms that may underpin eBL development and identify novel pathways that can be targeted in drug development. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Correction to: Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Author

Granai, Massimo, Mundo, Lucia, Akarca, Ayse U., Siciliano, Maria Chiara, Rizvi, Hasan, Mancini, Virginia, Onyango, Noel, Nyagol, Joshua, Abinya, Nicholas Othieno, Maha, Ibrahim, Margielewska, Sandra, Wei, Wenbin, Bibas, Michele, Piccaluga, Pier Paolo, Quintanilla-Martinez, Leticia, Fend, Falko, Lazzi, Stefano, Leoncini, Lorenzo, and Marafioti, Teresa

Published
2020
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7. Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program

Author

Granai, Massimo, Mundo, Lucia, Akarca, Ayse U., Siciliano, Maria Chiara, Rizvi, Hasan, Mancini, Virginia, Onyango, Noel, Nyagol, Joshua, Abinya, Nicholas Othieno, Maha, Ibrahim, Margielewska, Sandra, Wei, Wenbin, Bibas, Michele, Piccaluga, Pier Paolo, Quintanilla-Martinez, Leticia, Fend, Falko, Lazzi, Stefano, Leoncini, Lorenzo, and Marafioti, Teresa

Published
2020
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8. Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases

Author

Mundo, Lucia, Ambrosio, Maria Raffaella, Raimondi, Francesco, Del Porro, Leonardo, Guazzo, Raffaella, Mancini, Virginia, Granai, Massimo, Jim Rocca, Bruno, Lopez, Cristina, Bens, Susanne, Onyango, Noel, Nyagol, Joshua, Abinya, Nicholas, Navari, Mohsen, Ndede, Isaac, Patel, Kirkita, Paolo Piccaluga, Pier, Bob, Roshanak, de Santi, Maria Margherita, Russell, Robert B., Lazzi, Stefano, Siebert, Reiner, Stein, Harald, and Leoncini, Lorenzo

Published
2019
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9. Epstein–Barr Virus and the Pathogenesis of Diffuse Large B-Cell Lymphoma

Author

Ross, Aisling M., primary, Leahy, Ciara I., additional, Neylon, Fiona, additional, Steigerova, Jana, additional, Flodr, Patrik, additional, Navratilova, Martina, additional, Urbankova, Helena, additional, Vrzalikova, Katerina, additional, Mundo, Lucia, additional, Lazzi, Stefano, additional, Leoncini, Lorenzo, additional, Pugh, Matthew, additional, and Murray, Paul G., additional

Published
2023
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10. Correction: Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas

Author

Mundo, Lucia, Del Porro, Leonardo, Granai, Massimo, Siciliano, Maria Chiara, Mancini, Virginia, Santi, Raffaella, Marcar, Lynnette, Vrzalikova, Katerina, Vergoni, Federica, Di Stefano, Gioia, Schiavoni, Gianluca, Segreto, Giovanna, Onyango, Noel, Nyagol, Joshua Akelo, Amato, Teresa, Bellan, Cristiana, Anagnostopoulos, Ioannis, Falini, Brunangelo, Leoncini, Lorenzo, Tiacci, Enrico, and Lazzi, Stefano

Published
2020
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11. TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration

Author

Tosi, Gian Marco, Neri, Giovanni, Caldi, Elena, Fusco, Fiorella, Bacci, Tommaso, Tarantello, Antonio, Nuti, Elisabetta, Marigliani, Davide, Baiocchi, Stefano, Traversi, Claudio, Barbarino, Marcella, Eandi, Chiara M., Parolini, Barbara, Mundo, Lucia, Santucci, Annalisa, Orlandini, Maurizio, and Galvagni, Federico

Published
2018
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12. Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein–Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development

Author

Manara, Francesca, primary, Jay, Antonin, additional, Odongo, Grace, additional, Mure, Fabrice, additional, Maroui, Mohamed, additional, Diederichs, Audrey, additional, Sirand, Cecilia, additional, Cuenin, Cyrille, additional, Granai, Massimo, additional, Mundo, Lucia, additional, Hernandez-Vargas, Hector, additional, Lazzi, Stefano, additional, Khoueiry, Rita, additional, Gruffat, Henri, additional, Herceg, Zdenko, additional, and Accardi, Rosita, additional

Published
2022
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13. Cover Image

Author

Granai, Massimo, primary, Lazzi, Stefano, additional, Mancini, Virginia, additional, Akarca, Ayse, additional, Santi, Raffaella, additional, Vergoni, Federica, additional, Sorrentino, Ester, additional, Guazzo, Raffaella, additional, Mundo, Lucia, additional, Cevenini, Gabriele, additional, Tripodo, Claudio, additional, Di Stefano, Gioia, additional, Puccini, Benedetta, additional, Ponzoni, Maurilio, additional, Sabattini, Elena, additional, Agostinelli, Claudio, additional, Bassüllü, Nuray, additional, Tecimer, Tülay, additional, Demiroz, Ahu Senem, additional, Mnango, Leah, additional, Dirnhofer, Stephan, additional, Quintanilla‐Martinez, Leticia, additional, Marafioti, Teresa, additional, Fend, Falko, additional, and Leoncini, Lorenzo, additional

Published
2021
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14. Epstein–Barr virus reactivation influences clonal evolution in human herpesvirus‐8‐related lymphoproliferative disorders

Author

Granai, Massimo, primary, Facchetti, Mattia, additional, Mancini, Virginia, additional, Goedhals, Jacqueline, additional, Sherriff, Alicia, additional, Mundo, Lucia, additional, Bellan, Cristiana, additional, Amato, Teresa, additional, Sorrentino, Ester, additional, Ungari, Marco, additional, Raphael, Martine, additional, Leoncini, Lorenzo, additional, Facchetti, Fabio, additional, and Lazzi, Stefano, additional

Published
2021
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15. Metabolic Switch and Cytotoxic Effect of Metformin on Burkitt Lymphoma

Author

Bagaloni, Irene, primary, Visani, Axel, additional, Biagiotti, Sara, additional, Ruzzo, Annamaria, additional, Navari, Mohsen, additional, Etebari, Maryam, additional, Mundo, Lucia, additional, Granai, Massimo, additional, Lazzi, Stefano, additional, Isidori, Alessandro, additional, Loscocco, Federica, additional, Li, Jiejin, additional, Leoncini, Lorenzo, additional, Visani, Giuseppe, additional, Magnani, Mauro, additional, and Piccaluga, Pier Paolo, additional

Published
2021
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17. LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration

Author

Mundo, Lucia, primary, Tosi, Gian, additional, Lazzi, Stefano, additional, Pertile, Grazia, additional, Parolini, Barbara, additional, Neri, Giovanni, additional, Posarelli, Matteo, additional, De Benedetto, Elena, additional, Bacci, Tommaso, additional, Silvestri, Ennio, additional, Siciliano, Maria, additional, Barbera, Stefano, additional, Orlandini, Maurizio, additional, Greenwood, John, additional, Moss, Stephen, additional, and Galvagni, Federico, additional

Published
2021
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19. Burkitt lymphoma with a granulomatous reaction: an M1/Th1‐polarised microenvironment is associated with controlled growth and spontaneous regression

Author

Granai, Massimo, primary, Lazzi, Stefano, additional, Mancini, Virginia, additional, Akarca, Ayse, additional, Santi, Raffaella, additional, Vergoni, Federica, additional, Sorrentino, Ester, additional, Guazzo, Raffaella, additional, Mundo, Lucia, additional, Cevenini, Gabriele, additional, Tripodo, Claudio, additional, Di Stefano, Gioia, additional, Puccini, Benedetta, additional, Ponzoni, Maurilio, additional, Sabattini, Elena, additional, Agostinelli, Claudio, additional, Bassüllü, Nuray, additional, Tecimer, Tülay, additional, Demiroz, Ahu Senem, additional, Mnango, Leah, additional, Dirnhofer, Stephan, additional, Quintanilla‐Martinez, Leticia, additional, Marafioti, Teresa, additional, Fend, Falko, additional, and Leoncini, Lorenzo, additional

Published
2021
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20. EBV reactivation influences clonal evolution in HHV8 related lymphoprolipherative disorders?

Author

Granai, Massimo, Facchetti, Mattia, Mancini, Virginia, Goedhals, Jacqueline, Sherriff, Alicia, Mundo, Lucia, Bellan, Cristiana, Amato, Teresa, Sorrentino, Ester, Ungari, Marco, Raphael, Martine, Leoncini, Lorenzo, Facchetti, Fabio, and Lazzi, Stefano

Subjects
Castleman disease, EBV, KSHV/HHV8, germinotropic lymphoprolipherative disorder, pleural effusion Lymphoma
Published
2021

21. The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization

Author

Tosi, Gian Marco, Neri, Giovanni, Barbera, Stefano, Mundo, Lucia, Parolini, Barbara, Lazzi, Stefano, Lugano, Roberta, Poletto, Evelina, Leoncini, Lorenzo, Pertile, Grazia, Mongiat, Maurizio, Dimberg, Anna, Galvagni, Federico, Orlandini, Maurizio, Tosi, Gian Marco, Neri, Giovanni, Barbera, Stefano, Mundo, Lucia, Parolini, Barbara, Lazzi, Stefano, Lugano, Roberta, Poletto, Evelina, Leoncini, Lorenzo, Pertile, Grazia, Mongiat, Maurizio, Dimberg, Anna, Galvagni, Federico, and Orlandini, Maurizio

Abstract

PURPOSE. The purpose of this study was to investigate the involvement of CD93 and Multimerin-2 in three choroidal neovascularization (CNV) models and to evaluate their contribution in the neovascular progression of age-related macular degeneration (AMD). METHODS. Choroidal neovascular membranes collected during surgery from AMD patients were analyzed by microscopy methods. Laser-induced CNV mouse models and choroid sprouting assays (CSAs) were carried out using the CD93 knockout mouse model. An original ex vivo CSA of vascular angiogenesis, employing choroid tissues isolated from human donors, was developed. RESULTS. In contrast to healthy choroid endothelium, hyperproliferative choroidal endothelial cells (ECs) of AMD patients expressed high levels of CD93, and Multimerin-2 was abundantly deposited along the choroidal neovasculature. CD93 knockout mice showed a significant reduced neovascularization after laser photocoagulation, and their choroidal ECs displayed a decreased ability to produce sprouts in ex vivo angiogenesis assays. Moreover, the presence of an antibody able to hamper the CD93/Multimerin-2 interaction reduced vascular sprouting in the human CSA. CONCLUSIONS. Our results demonstrate that CD93 and its interaction with Multimerin-2 play an important role in pathological vascularization of the choroid, disclosing new possibilities for therapeutic intervention to neovascular AMD.

Published
2020
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22. MiR-200c-3p Contrasts PD-L1 Induction by Combinatorial Therapies and Slows Proliferation of Epithelial Ovarian Cancer through Downregulation of β-Catenin and c-Myc

Author

Anastasiadou, Eleni, primary, Messina, Elena, additional, Sanavia, Tiziana, additional, Mundo, Lucia, additional, Farinella, Federica, additional, Lazzi, Stefano, additional, Megiorni, Francesca, additional, Ceccarelli, Simona, additional, Pontecorvi, Paola, additional, Marampon, Francesco, additional, Di Gioia, Cira Rosaria Tiziana, additional, Perniola, Giorgia, additional, Panici, Pierluigi Benedetti, additional, Leoncini, Lorenzo, additional, Trivedi, Pankaj, additional, Lenzi, Andrea, additional, and Marchese, Cinzia, additional

Published
2021
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23. The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization

Author

Tosi, Gian Marco, primary, Neri, Giovanni, additional, Barbera, Stefano, additional, Mundo, Lucia, additional, Parolini, Barbara, additional, Lazzi, Stefano, additional, Lugano, Roberta, additional, Poletto, Evelina, additional, Leoncini, Lorenzo, additional, Pertile, Grazia, additional, Mongiat, Maurizio, additional, Dimberg, Anna, additional, Galvagni, Federico, additional, and Orlandini, Maurizio, additional

Published
2020
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24. Immune Landscape in Burkitt Lymphoma reveals M2-macrophage polarization and Correlation between PD-L1 expression and Non-Canonical EBV latency program

Author

Granai, Massimo, primary, Mundo, Lucia, additional, Akarca, Ayse U, additional, Siciliano, Maria Chiara, additional, Rizvi, Hasan, additional, Mancini, Virginia, additional, Onyango, Noel, additional, Othieno-Abinya, Nicholas, additional, Maha, Ibrahim, additional, Margielewska, Sandra, additional, Wi, Wenbin, additional, Bibas, Michele, additional, Piccaluga, Pier Paolo, additional, Quintanilla-Martinez, Leticia, additional, Fend, Falko, additional, Lazzi, Stefano, additional, Leoncini, Lorenzo, additional, and Marafioti, Teresa, additional

Published
2020
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25. Burkitt lymphoma with a granulomatous reaction: an M1/Th1-polarised microenvironment is associated with controlled growth and spontaneous regression.

Author

Granai, Massimo, Lazzi, Stefano, Mancini, Virginia, Akarca, Ayse, Santi, Raffaella, Vergoni, Federica, Sorrentino, Ester, Guazzo, Raffaella, Mundo, Lucia, Cevenini, Gabriele, Tripodo, Claudio, Di Stefano, Gioia, Puccini, Benedetta, Ponzoni, Maurilio, Sabattini, Elena, Agostinelli, Claudio, Bassüllü, Nuray, Tecimer, Tülay, Demiroz, Ahu Senem, and Mnango, Leah

Subjects
TH1 cells, LYMPHOMAS, CELL morphology, TUMOR microenvironment, EPSTEIN-Barr virus
Abstract

Aims: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously. Methods and results: All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein-Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a proinflammatory response triggered by Th1 lymphocytes and M1 polarised macrophages encircling the neoplastic cells with a peculiar topographic distribution. Conclusions: Our data provide an in-vivo picture of the role that specific immune cell subsets might play during the early phase of BL, which may be capable of maintaining the tumour in a self-limited state or inducing its regression. These novel results may provide insights into new potential therapeutic avenues in EBV-positive BL patients in the era of cellular immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection

Author

Vargas-Ayala, Romina C., primary, Jay, Antonin, additional, Manara, Francesca, additional, Maroui, Mohamed Ali, additional, Hernandez-Vargas, Hector, additional, Diederichs, Audrey, additional, Robitaille, Alexis, additional, Sirand, Cecilia, additional, Ceraolo, Maria Grazia, additional, Romero-Medina, Maria Carmen, additional, Cros, Marie Pierre, additional, Cuenin, Cyrille, additional, Durand, Geoffroy, additional, Le Calvez-Kelm, Florence, additional, Mundo, Lucia, additional, Leoncini, Lorenzo, additional, Manet, Evelyne, additional, Herceg, Zdenko, additional, Gruffat, Henri, additional, and Accardi, Rosita, additional

Published
2019
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27. Role of Epstein-Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature

Author

Granai, Massimo, primary, Ambrosio, Maria Raffaella, additional, Akarca, Ayse, additional, Mundo, Lucia, additional, Vergoni, Federica, additional, Santi, Raffaella, additional, Mancini, Virginia, additional, di Stefano, Gioia, additional, Amato, Teresa, additional, Bellan, Cristiana, additional, Puccini, Benedetta, additional, Sorrentino, Ester, additional, Naresh, Kikkeri N., additional, Leoncini, Lorenzo, additional, Marafioti, Teresa, additional, and Lazzi, Stefano, additional

Published
2019
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28. p66Shc deficiency in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape

Author

Patrussi, Laura, primary, Capitani, Nagaja, additional, Ulivieri, Cristina, additional, Manganaro, Noemi, additional, Granai, Massimo, additional, Cattaneo, Francesca, additional, Kabanova, Anna, additional, Mundo, Lucia, additional, Gobessi, Stefania, additional, Frezzato, Federica, additional, Visentin, Andrea, additional, Finetti, Francesca, additional, Pelicci, Pier Giuseppe, additional, D’Elios, Mario M., additional, Trentin, Livio, additional, Semenzato, Gianpietro, additional, Leoncini, Lorenzo, additional, Efremov, Dimitar G., additional, and Baldari, Cosima T., additional

Published
2019
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29. Putative Role of Circulating Human Papillomavirus DNA in the Development of Primary Squamous Cell Carcinoma of the Middle Rectum: A Case Report

Author

Ambrosio, Maria Raffaella, primary, Vernillo, Remo, additional, De Carolis, Sabrina, additional, Carducci, Antonietta, additional, Mundo, Lucia, additional, Ginori, Alessandro, additional, Rocca, Bruno Jim, additional, Nardone, Valerio, additional, Lucenti Fei, Alessandra, additional, Carfagno, Tommaso, additional, Lazzi, Stefano, additional, Cricca, Monica, additional, and Tosi, Piero, additional

Published
2019
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31. Interplay between the epigenetic enzyme lysine (K)-specific demethylase 2B and Epstein-Barr virus infection

Author

Vargas-Ayala, Romina C., primary, Jay, Antonin, additional, Hernandez-Vargas, Hector, additional, Diederichs, Audrey, additional, Robitaille, Alexis, additional, Sirand, Cecilia, additional, Ceraolo, Maria Grazia, additional, Romero, Maria, additional, Cros, Marie Pierre, additional, Cuenin, Cyrille, additional, Durand, Geoffroy, additional, Calvez-Kelm, Florence Le, additional, Mundo, Lucia, additional, Maroui, Mohamed Ali, additional, Leoncini, Lorenzo, additional, Manet, Evelyne, additional, Herceg, Zdenko, additional, Gruffat, Henri, additional, and Accardi, Rosita, additional

Published
2018
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32. Publisher Correction: TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration

Author

Tosi, Gian Marco, primary, Neri, Giovanni, additional, Caldi, Elena, additional, Fusco, Fiorella, additional, Bacci, Tommaso, additional, Tarantello, Antonio, additional, Nuti, Elisabetta, additional, Marigliani, Davide, additional, Baiocchi, Stefano, additional, Traversi, Claudio, additional, Barbarino, Marcella, additional, Eandi, Chiara M., additional, Parolini, Barbara, additional, Mundo, Lucia, additional, Santucci, Annalisa, additional, Orlandini, Maurizio, additional, and Galvagni, Federico, additional

Published
2018
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33. MYC protein expression scoring and its impact on the prognosis of aggressive B-cell lymphoma patients

Author

Ambrosio, Maria R., primary, Lazzi, Stefano, additional, Bello, Giuseppe Lo, additional, Santi, Raffaella, additional, Porro, Leonardo Del, additional, de Santi, Maria M., additional, Guazzo, Raffaella, additional, Mundo, Lucia, additional, Rigacci, Luigi, additional, Kovalchuck, Sofia, additional, Onyango, Noel, additional, Fabbri, Alberto, additional, Cencini, Emanuele, additional, Zinzani, Pier Luigi, additional, Zaja, Francesco, additional, Angrilli, Francesco, additional, Stelitano, Caterina, additional, Cabras, Maria G., additional, Spataro, Giuseppe, additional, Bob, Roshanak, additional, Menter, Thomas, additional, Granai, Massimo, additional, Cevenini, Gabriele, additional, Naresh, Kikkeri N., additional, Stein, Harald, additional, Sabattini, Elena, additional, and Leoncini, Lorenzo, additional

Published
2018
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34. MicroRNAs sequencing unveils distinct molecular subgroups of plasmablastic lymphoma

Author

Ambrosio, Maria Raffaella, primary, Mundo, Lucia, additional, Gazaneo, Sara, additional, Picciolini, Matteo, additional, Vara, Prasad Satya, additional, Sayed, Shaheen, additional, Ginori, Alessandro, additional, Lo Bello, Giuseppe, additional, Del Porro, Leonardo, additional, Navari, Mohsen, additional, Ascani, Stefano, additional, Yonis, Amhed, additional, Leoncini, Lorenzo, additional, Piccaluga, Pier Paolo, additional, and Lazzi, Stefano, additional

Published
2017
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36. Unveiling Another Missing Piece in EBV-Driven Lymphomagenesis: EBV-Encoded MicroRNAs Expression in EBER-Negative Burkitt Lymphoma Cases

Author

Mundo, Lucia, primary, Ambrosio, Maria R., additional, Picciolini, Matteo, additional, Lo Bello, Giuseppe, additional, Gazaneo, Sara, additional, Del Porro, Leonardo, additional, Lazzi, Stefano, additional, Navari, Mohsen, additional, Onyango, Noel, additional, Granai, Massimo, additional, Bellan, Cristiana, additional, De Falco, Giulia, additional, Gibellini, Davide, additional, Piccaluga, Pier P., additional, and Leoncini, Lorenzo, additional

Published
2017
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37. Additional file 3: Table S3. of Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Author

Falco, Giulia De, Ambrosio, Maria, Fuligni, Fabio, Onnis, Anna, Bellan, Cristiana, Rocca, Bruno, Navari, Mohsen, Etebari, Maryam, Mundo, Lucia, Gazaneo, Sara, Facchetti, Fabio, Pileri, Stefano, Leoncini, Lorenzo, and Piccaluga, Pier

Abstract

Gene set enrichment analysis for gene ontology categories of 64 genes predicted as targets of microRNAs differentially expressed in MYC translocation-positive and -negative BLs. (DOC 67 kb)

Published
2015
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38. Additional file 2: Table S2. of Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Author

Falco, Giulia De, Ambrosio, Maria, Fuligni, Fabio, Onnis, Anna, Bellan, Cristiana, Rocca, Bruno, Navari, Mohsen, Etebari, Maryam, Mundo, Lucia, Gazaneo, Sara, Facchetti, Fabio, Pileri, Stefano, Leoncini, Lorenzo, and Piccaluga, Pier

Subjects
hemic and lymphatic diseases, mental disorders, education
Abstract

Predicted target genes of miRNAs differentially expressed in MYC translocation-positive and -negative BLs. (DOC 50 kb)

Published
2015
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39. Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma

Author

Abate, Francesco, primary, Ambrosio, Maria Raffaella, additional, Mundo, Lucia, additional, Laginestra, Maria Antonella, additional, Fuligni, Fabio, additional, Rossi, Maura, additional, Zairis, Sakellarios, additional, Gazaneo, Sara, additional, De Falco, Giulia, additional, Lazzi, Stefano, additional, Bellan, Cristiana, additional, Rocca, Bruno Jim, additional, Amato, Teresa, additional, Marasco, Elena, additional, Etebari, Maryam, additional, Ogwang, Martin, additional, Calbi, Valeria, additional, Ndede, Isaac, additional, Patel, Kirtika, additional, Chumba, David, additional, Piccaluga, Pier Paolo, additional, Pileri, Stefano, additional, Leoncini, Lorenzo, additional, and Rabadan, Raul, additional

Published
2015
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40. Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Author

De Falco, Giulia, primary, Ambrosio, Maria Raffaella, additional, Fuligni, Fabio, additional, Onnis, Anna, additional, Bellan, Cristiana, additional, Rocca, Bruno Jim, additional, Navari, Mohsen, additional, Etebari, Maryam, additional, Mundo, Lucia, additional, Gazaneo, Sara, additional, Facchetti, Fabio, additional, Pileri, Stefano A., additional, Leoncini, Lorenzo, additional, and Piccaluga, Pier Paolo, additional

Published
2015
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43. Abstract 5173: Identification of single-nucleotide variants by high-throughput RNA sequencing in endemic Burkitt Lymphoma

Author

Laginestra, Maria Antonella, primary, Abate, Francesco, additional, Etebari, Maryam, additional, Falco, Giulia D., additional, Fuligni, Fabio, additional, Rossi, Maura, additional, Zairis, Sakellarios, additional, Sapienza, Maria Rosaria, additional, Gazzola, Anna, additional, Mannu, Claudia, additional, Melle, Federica, additional, Agostinelli, Claudio, additional, Navari, Mohsen, additional, Bellan, Cristiana, additional, Gazaneo, Sara, additional, Mundo, Lucia, additional, Ogwang, Martin, additional, Calbi, Valeria, additional, Leoncini, Lorenzo, additional, Pileri, Stefano A., additional, Rabadan, Raul, additional, and Piccaluga, Pier Paolo, additional

Published
2014
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44. The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma

Author

Ambrosio, Maria Raffaella, primary, Navari, Mohsen, additional, Di Lisio, Lorena, additional, Leon, Eduardo Andres, additional, Onnis, Anna, additional, Gazaneo, Sara, additional, Mundo, Lucia, additional, Ulivieri, Cristina, additional, Gomez, Gonzalo, additional, Lazzi, Stefano, additional, Piris, Miguel Angel, additional, Leoncini, Lorenzo, additional, and De Falco, Giulia, additional

Published
2014
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46. Cover Image.

Author

Granai, Massimo, Lazzi, Stefano, Mancini, Virginia, Akarca, Ayse, Santi, Raffaella, Vergoni, Federica, Sorrentino, Ester, Guazzo, Raffaella, Mundo, Lucia, Cevenini, Gabriele, Tripodo, Claudio, Di Stefano, Gioia, Puccini, Benedetta, Ponzoni, Maurilio, Sabattini, Elena, Agostinelli, Claudio, Bassüllü, Nuray, Tecimer, Tülay, Demiroz, Ahu Senem, and Mnango, Leah

Subjects
LYMPHOMAS
Published
2022
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47. Effects of Epstein-Barr Virus Infection on the Risk and Prognosis of Primary Laryngeal Squamous Cell Carcinoma: A Hospital-Based Case-Control Study in Taiwan.

Author

Lee, Li-Ang, Fang, Tuan-Jen, Li, Hsueh-Yu, Chuang, Hai-Hua, Kang, Chung-Jan, Chang, Kai-Ping, Liao, Chun-Ta, Chen, Tse-Ching, Huang, Chung-Guei, Yen, Tzu-Chen, Leoncini, Lorenzo, and Mundo, Lucia

Subjects
DISEASE relapse, HOSPITALS, DNA, MULTIVARIATE analysis, AGE distribution, LARYNGEAL tumors, CASE-control method, IN situ hybridization, DESCRIPTIVE statistics, SURVIVAL analysis (Biometry), POLYMERASE chain reaction, SMOKING, EPSTEIN-Barr virus diseases, SQUAMOUS cell carcinoma, ANTIGENS, DISEASE risk factors, DISEASE complications
Abstract

Simple Summary: Epstein–Barr virus DNA positivity, age ≥ 55 years, cigarette smoking, and high BCL-2, B2M, and CD161 expression were identified as independent risk factors for primary laryngeal squamous cell carcinoma. A high EBER signal and low CD3 expression significantly and independently predicted local recurrence and disease-free survival within five years. The information obtained in this study improves our understanding of viral infections in laryngeal cancer, and may guide future prevention, treatment, and follow-up strategies. Mounting molecular evidence supports Epstein–Barr virus (EBV) involvement in the pathogenesis of laryngeal squamous cell carcinoma (LSCC); however, the epidemiological data are inconsistent. In this retrospective case-control study, we aimed to determine whether EBV infection underlies the risk and prognosis of LSCC. The prevalence of EBV infection, as analyzed using an EBV DNA polymerase chain reaction assay, was significantly higher in 42 Taiwanese patients with newly diagnosed primary LSCC, compared to 39 age- and sex-matched control patients without cancer (48% vs. 19%). Furthermore, most of the EBER signals detected using in situ hybridization were localized to the nuclei of tumor-infiltrating lymphocytes. In multivariate analysis, EBV DNA positivity, age ≥ 55 years, cigarette smoking, and high BCL-2, B2M, and CD161 expression (assessed using immunohistochemistry) were identified as independent risk factors for LSCC. Furthermore, five-year local recurrence and disease-free survival rates were 34% and 58%, respectively, with a high EBER signal and low CD3 expression independently predicting five-year local recurrence and disease-free survival. Our comprehensive profiling data accurately identified patients at risk for LSCC development, local recurrence, or disease-free survival. The information obtained in this study improves our understanding of EBV infection in LSCC, and may guide precision medicine for patients with LSCC. [ABSTRACT FROM AUTHOR]

Published
2021
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48. EBV and the Pathogenesis of NK/T Cell Lymphoma.

Author

Montes-Mojarro, Ivonne A., Fend, Falko, Quintanilla-Martinez, Leticia, Leoncini, Lorenzo, Accardi-Gheit, Rosita, and Mundo, Lucia

Subjects
SEQUENCE analysis, GENETIC mutation, ONCOGENES, EPSTEIN-Barr virus, GENOMICS, T-cell lymphoma
Abstract

Simple Summary: Extranodal NK/T cell lymphoma (ENKTCL) is an aggressive lymphoma associated with Epstein-Barr virus (EBV) infection that occurs mainly in Asian and Latin American populations. In the last decade, the genetic landscape of ENKTCL has been characterized comprehensively using next-generation sequencing (NGS). This and similar high-throughput approaches revealed that these lymphomas are distinguished by frequent gene mutations leading to activation of the JAK-STAT pathway, and mutations in other genes such as BCOR, DDX3X and TP53. This review aims to provide a comprehensive overview about the role of EBV infection and a comparison of the EBV strains and LMP1 variants among different populations. Moreover, a brief summary of the ENKTCL genetic landscape is presented, highlighting the main therapeutically targetable pathways in ENKTCL oncogenesis: the JAK-STAT signaling pathway, the immune response evasion, MYC overexpression, as well as epigenetic alterations. Epstein-Barr virus (EBV) is a ubiquitous gamma herpes virus with tropism for B cells. EBV is linked to the pathogenesis of B cell, T cell and NK cell lymphoproliferations, with extranodal NK/T cell lymphoma, nasal type (ENKTCL) being the prototype of an EBV-driven lymphoma. ENKTCL is an aggressive neoplasm, particularly widespread in East Asia and the native population of Latin America, which suggests a strong genetic predisposition. The link between ENKTCL and different populations has been partially explored. EBV genome sequencing analysis recognized two types of strains and identified variants of the latent membrane protein 1 (LMP1), which revealed different oncogenic potential. In general, most ENKTCL patients carry EBV type A with LMP1 wild type, although the LMP1 variant with a 30 base pair deletion is also common, especially in the EBV type B, where it is necessary for oncogenic transformation. Contemporary high-throughput mutational analyses have discovered recurrent gene mutations leading to activation of the JAK-STAT pathway, and mutations in other genes such as BCOR, DDX3X and TP53. The genomic landscape in ENKTCL highlights mechanisms of lymphomagenesis, such as immune response evasion, secondary to alterations in signaling pathways or epigenetics that directly or indirectly interfere with oncogenes or tumor suppressor genes. This overview discusses the most important findings of EBV pathogenesis and genetics in ENKTCL. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Is EBV Associated with Breast Cancer in Specific Geographic Locations?

Author

Sinclair, Alison J., Moalwi, Manal H., Amoaten, Thomas, Accardi-Gheit, Rosita, Leoncini, Lorenzo, and Mundo, Lucia

Subjects
STOMACH tumors, CYTOCHEMISTRY, GENE expression, EPSTEIN-Barr virus, BREAST tumors, NASOPHARYNX tumors
Abstract

Simple Summary: Epstein–Barr virus (EBV) is a virus that infects people and then remains within their bodies for life. Almost everyone is infected with EBV by the time they are an adult. EBV is called a cancer virus because it causes some cancers of blood cells and some cancers of the stomach and nose. Some scientists think that EBV may also cause some cases of breast cancer, but others disagree. It is difficult to be sure whether a pathogen that most people are infected with is the cause of any disease. Here, we review and discuss the evidence for and against the link between EBV and breast cancer and pose the questions that could help to answer whether EBV is a cause of breast cancer. Epstein–Barr virus (EBV) is a virus that establishes a life-long infection in people, and infection with EBV is nearly ubiquitous by adulthood. EBV was identified from biopsy material from a child with Burkitt's lymphoma (BL) in sub-Saharan Africa. EBV has a well-characterised role in the development of some cancers, notably, Burkitt's lymphoma (BL), Hodgkin's disease (HD), gastric carcinoma (GC), and nasopharyngeal carcinoma (NPC). Links have also been made between EBV and breast cancer (BC), but these have been controversial. For all EBV-associated cancers, the ubiquitous nature of infection with EBV, contrasted with the relatively rare development of cancer, highlights a problem of determining whether EBV is an aetiological agent of cancer. In addition, the geographic distributions of some EBV-associated cancers point to contributions from additional co-factors. Recent meta-analyses of the incidence of EBV within BC biopsies has revealed that the diversity in the conclusions remain, however, they also show more of an association between EBV and BC biopsies in some study locations. Here, we review the evidence linking EBV with BC, and conclude that the evidence for the presence of EBV in BC biopsies is concentrated in specific geographic regions but is currently insufficient to provide a causal link. We pose some questions that could help to resolve the question of whether EBV contributes to BC and probe the contribution EBV might make to the aetiology of BC. [ABSTRACT FROM AUTHOR]

Published
2021
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50. Comprehensive Epstein-Barr Virus Transcriptome by RNA-Sequencing in Angioimmunoblastic T Cell Lymphoma (AITL) and Other Lymphomas.

Author

Bayda, Nader, Tilloy, Valentin, Chaunavel, Alain, Bahri, Racha, Halabi, Mohamad Adnan, Feuillard, Jean, Jaccard, Arnaud, Ranger-Rogez, Sylvie, Accardi-Gheit, Rosita, Leoncini, Lorenzo, and Mundo, Lucia

Subjects
RNA analysis, SEQUENCE analysis, GENE expression profiling, EPSTEIN-Barr virus, CELL lines, T-cell lymphoma
Abstract

Simple Summary: Angioimmunoblastic T cell lymphoma (AITL) is probably the most common peripheral T-cell lymphoma. This pathology, although rare, is more common in Europe than in other regions. This lymphoma has a poor prognosis. AITL is very commonly associated with the Epstein-Barr virus (EBV) although the virus is not often found in neoplastic T cells but rather in adjacent B cells. Our objective was to study the transcriptome of EBV in AITLs comparatively to other EBV-associated lymphomas and to compare the results with those obtained for cell lines. We showed in AITLs a strong expression of Bam-HI A rightward transcripts (BARTs) more expressed than in the other lymphomas and especially than in cell lines. BARTs can participate in tumor development. We also showed a latency IIc in AITLs with the expression of BNLF2a and BCRF1 genes which may participate in the survival of infected cells. These results support the involvement of EBV in AITLs. The Epstein–Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We used next-generation sequencing (NGS) to study EBV transcriptome in 14 AITLs compared to 21 other lymphoma samples and 11 cell lines including 4 lymphoblastoid cell lines (LCLs). Viral transcripts were recovered using capture probes and sequencing was performed on Illumina. Bam-HI A rightward transcripts (BARTs) were the most latency transcripts expressed in AITLs, suggesting they may play a role in this pathology. Thus, BARTs, already described as highly expressed in carcinoma cells, are also very present in AITLs and other lymphomas. They were poorly expressed in cell lines other than LCLs. AITLs showed a latency IIc, with BNLF2a gene expression. For most AITLs, BCRF1, which encodes a homologous protein of human interleukin 10, vIL-10, was in addition expressed. This co-expression can contribute to immune escape and survival of infected cells. Considering these results, it can be assumed that EBV plays a pathogenic role in AITLs. [ABSTRACT FROM AUTHOR]

Published
2021
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