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1. MAGIC detection of short-term variability of the high-peaked BL Lac object lES 0806+524

Author

Aleksic J, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Bangale P, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Caneva G, De Lotto B, Wilhelmi ED, Mendez CD, Di Pierro F, Prester DD, Dorner D, Doro M, Einecke S, Eisenacher D, Elsaesser D, Fernandez Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Godinovic N, Munoz AG, Gozzini SR, Hadasch D, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Idec W, Kadenius V, Kellermann H, Knoetig ML, Kodani K, Konno Y, Krause J, Kubo H, Kushida J, La Barbera A, Lelas D, Lewandowska N, Lindfors E, Lombardi S, Longo F, Lopez M, Lopez Coto R, Lopez Oramas A, Lorenz E, Lozano I, Makariev M, Mallot K, Maneva G, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Munar Adrover P, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo MN, Nilsson K, Nishijima K, Noda K, Orito R, Overkemping A, Paiano S, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes Fortuny X, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Reinthal R, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Saito K, Satalecka K, Scalzotto V, Scapin V, Schultz C, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Toyama DFTT, Toyama T, Treves A, Vogler P, Will M, Zanin R, Berger K, Buson S, Gasparrini D, Hovatta T, Max Moerbeck W, Readhead A, Richards J., D'AMMANDO, FILIPPO, Aleksic J, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Bangale P, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Caneva G, De Lotto B, Wilhelmi ED, Mendez CD, Di Pierro F, Prester DD, Dorner D, Doro M, Einecke S, Eisenacher D, Elsaesser D, Fernandez-Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Godinovic N, Munoz AG, Gozzini SR, Hadasch D, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Idec W, Kadenius V, Kellermann H, Knoetig ML, Kodani K, Konno Y, Krause J, Kubo H, Kushida J, La Barbera A, Lelas D, Lewandowska N, Lindfors E, Lombardi S, Longo F, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Lozano I, Makariev M, Mallot K, Maneva G, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Munar-Adrover P, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo MN, Nilsson K, Nishijima K, Noda K, Orito R, Overkemping A, Paiano S, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Reinthal R, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Saito K, Satalecka K, Scalzotto V, Scapin V, Schultz C, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Toyama DFTT, Toyama T, Treves A, Vogler P, Will M, Zanin R, Berger K, Buson S, DAmmando F, Gasparrini D, Hovatta T, Max-Moerbeck W, Readhead A, and Richards J

Subjects
radiation mechanisms: non-thermal, galaxies: active, BL Lacertae objects: individual: 1ES 0806+524, galaxies: jets, gamma rays: galaxies, Astrophysics::High Energy Astrophysical Phenomena
Abstract

The high-frequency-peaked BL Lac (HBL) 1ES 0806+524 (z = 0.138) was discovered in very high energy (VHE) gamma-rays in 2008. Until now, the broad-band spectrum of lES 0806+524 has been only poorly characterized, in particular at high energies. We analysed multiwave-length observations from gamma-rays to radio performed from 2011 January to March, which were triggered by the high activity detected at optical frequencies. These observations constitute the most precise determination of the broad-band emission of ES 0806+524 to date. The stereoscopic Major Atmospheric Gamma-Ray Imaging Cherenkov (MAGIC) observations yielded a gamma-ray signal above 250 GeV of (3.7 +/- 0.7) per cent of the Crab Nebula flux with a statistical significance of 9.9a. The multiwavelength observations showed significant variability in essentially all energy bands, including a VHE gamma-ray flare that lasted less than one night, which provided unprecedented evidence for short-term variability in lES 0806+524. The spectrum of this flare is well described by a power law with a photon index of 2.97 +/- 0.29 between similar to 150 GeV and 1 TeV and an integral flux of (9.3 +/- 1.9) per cent of the Crab nebula flux above 250 GeV. The spectrum during the non-flaring VHE activity is compatible with the only available VHE observation performed in 2008 with VERITAS when the source was in a low optical state. The broad-band spectral energy distribution can be described with a one-zone synchrotron self-Compton model with parameters typical for HBLs, indicating that lES 0806+524 is not substantially different from the HBLs previously detected.

Published
2015

2. Deep mitochondrial divergence within a Heliconius butterfly species is not explained by cryptic speciation or endosymbiotic bacteria

Author

Munoz, AG, Baxter, SW, Linares, M, Jiggins, CD, Munoz, AG, Baxter, SW, Linares, M, and Jiggins, CD

Abstract

BACKGROUND: Cryptic population structure can be an indicator of incipient speciation or historical processes. We investigated a previously documented deep break in the mitochondrial haplotypes of Heliconius erato chestertonii to explore the possibility of cryptic speciation, and also the possible presence of endosymbiont bacteria that might drive mitochondrial population structure. RESULTS: Among a sample of 315 individuals from 16 populations of western Colombia, two principal mtDNA clades were detected with 2.15% divergence and we confirmed this structure was weakly associated with geography. The first mtDNA clade included 87% of individuals from northern populations and was the sister group of H. erato members of Andes western, while the second clade contained most individuals from southern populations (78%), which shared haplotypes with an Ecuadorian race of H. erato. In contrast, analysis using AFLP markers showed H. e. chestertonii to be a genetically homogeneous species with no association between mitochondrial divergence and AFLP structure. The lack of congruence between molecular markers suggests that cryptic speciation is not a plausible explanation for the deep mitochondrial divergence in H. e chestertonii. We also carried out the first tests for the presence of endosymbiontic bacteria in Heliconius, and identified two distinct lineages of Wolbachia within H. e. chestertonii. However, neither of the principal mitochondrial clades of H. e. chestertonii was directly associated with the patterns of infection. CONCLUSIONS: We conclude that historical demographic processes are the most likely explanation for the high mitochondrial differentiation in H. e. chestertonii, perhaps due to gene flow between Cauca valley H. e. chestertonii and west Pacific slope populations of H. erato.

Published
2011

3. Dyslipidaemia in HIV-infected women on antiretroviral therapy. Analysis of 922 patients from the Spanish VACH cohort

Author

Estrada Vicente, Geijo Paloma, Fuentes-Ferrer Manuel, Alcalde María, Rodrigo María, Galindo María, Muñoz Agustín, Domingo Pere, Ribera Esteve, Cosín Jaime, Viciana Pompeyo, Lozano Fernando, Terrón Alberto, Vergara Antonio, Teira Ramón, Muñoz-Sánchez Josefa, Roca Bernardino, Sánchez Trinitario, López-Aldeguer José, Deig Elisabeth, Vidal Francisco, Pedrol Enric, Castaño-Carracedo Manuel, Puig Teresa, Garrido Myriam, and Suárez-Lozano Ignacio

Subjects
Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Information concerning lipid disturbances in HIV-infected women on antiretroviral therapy (ART) is scarce. The objective of the study is to describe the lipid profile in a large cohort of HIV-infected women on contemporary ART and analyse differences between regimes and patient's characteristics. Methods Observational, multicentre, cross-sectional study from the Spanish VACH Cohort. 922 women on stable ART without lipid-lowering treatment were included. Results Median age was 42 years, median CD4 lymphocyte count was 544 cells/mm3, and 85.6% presented undetectable HIV-1 viral load. Median total cholesterol (TC) was 189 mg/dL (interquartile range, IQR, 165-221), HDL cholesterol 53 mg/dL (IQR, 44-64), LDL cholesterol 108 mg/dL (IQR, 86-134), and triglycerides 116 mg/dL (IQR, 85-163). Mean accumulated time on ART was 116 months; 47.4% were on NNRTI-based regimes, 44.7% on PI, and 6.7% on only-NRTI therapy. 43.8% were also hepatitis C (HCV) coinfected. Patients on PI treatment presented higher TC/HDL ratio than those on NNRTI (p < 0.001). Significantly higher HDL values were observed in NNRTI-treated patients. HCV-coinfected patients presented lower TC/HDL ratio than the non HCV-coinfected. In multivariate analysis, factors independently associated with TC/HDL ratio were age, triglyceride levels and HCV co-infection. PI treatment presented a non-significant association with higher TC/HDL ratio. Conclusions In HIV-infected women, the NNRTI-based ART is associated with a better lipid profile than the PI-based. Factors unrelated to ART selection may also exert an independent, significant influence on lipids; in particular, age, and triglyceride levels are associated with an increased TC/HDL ratio while HCV co-infection is associated with a reduced TC/HDL ratio.

Published
2011
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4. Investigating the peculiar emission from the new VHE gamma-ray source H1722+119

Author

M. Hayashida, M. Makariev, B. Biasuzzi, K. Mallot, R. J. García López, Louis Antonelli, D. Dominis Prester, E. Prandini, M. Doert, M. H. Wu, Massimo Persic, F. D'Ammando, Marc Ribó, G. Bonnoli, Abelardo Moralejo, Juri Poutanen, R. Reinthal, V. Fallah Ramazani, P. Bangale, Y. Hanabata, Razmik Mirzoyan, U. Barres de Almeida, Damir Lelas, T. Steinbring, Marina Manganaro, P. G. Prada Moroni, Stefano Covino, Hidetoshi Kubo, P. Antoranz, D. Galindo, J. Becerra González, G. Pedaletti, Dorota Sobczyńska, D. Nakajima, Thomas Bretz, J. Hose, Andrei Berdyugin, Pratik Majumdar, M. V. Fonseca, S. Bonnefoy, A. Sillanpää, Arka Chatterjee, Francesco Longo, D. Elsaesser, F. Di Pierro, K. Kodani, Alexander Hahn, Konstancja Satalecka, Walter Max-Moerbeck, Tomoki Saito, D. Tescaro, Ivica Puljak, Pierre Colin, H. Takami, L. Nogués, U. Menzel, Michele Doro, M. I. Martínez, Gareth Hughes, Talvikki Hovatta, C. Schultz, E. Moretti, Marcel Strzys, D. Fidalgo, Vassil Verguilov, Aaron Dominguez, Diego F. Torres, Julia Thaele, E. de Oña Wilhelmi, Reiko Orito, F. Verrecchia, Sabrina Einecke, Junko Kushida, P. Da Vela, R. López-Coto, J. Rodriguez Garcia, J. E. Ward, M. Palatiello, Elina Lindfors, A. Niedzwiecki, Kyoshi Nishijima, Ievgen Vovk, Wolfgang Rhode, Daniel Mazin, Oscar Blanch, Julian Sitarek, Juan Abel Barrio, L. Maraschi, Francesco Dazzi, David Paneque, A. Fernández-Barral, Markus Garczarczyk, Yusuke Konno, C. Fruck, B. De Lotto, M. Villata, T. Schweizer, T. Toyama, D. Guberman, Tomislav Terzić, K. Frantzen, J. L. Richards, Mosè Mariotti, A.-K. Overkemping, S. Paiano, Saverio Lombardi, Karl Mannheim, D. Hadasch, L. Perri, A. La Barbera, D. Eisenacher Glawion, X. Paredes-Fortuny, P. Temnikov, M. Nievas Rosillo, W. Idec, A. González Muñoz, E. Colombo, B. Banerjee, S. Buson, L. O. Takalo, Masahiro Teshima, Daniela Dorner, R. Zanin, Dariusz Gora, Adrian Biland, M. Gaug, J. Rico, J. Herrera, Koji Noda, Elisa Bernardini, A. De Angelis, A. Treves, Vitaly Neustroev, Jose Luis Contreras, Juan Cortina, G. Maneva, C. M. Raiteri, Nikola Godinovic, Benito Marcote, Max Ludwig Ahnen, Kari Nilsson, P. Giammaria, M. Will, Dario Hrupec, M. A. Lopez, R. Clavero, D. Garrido Terrats, W. Bednarek, Fabrizio Tavecchio, Ll. Font, I. Snidaric, Ana Babić, Stefano Ansoldi, Riccardo Paoletti, J. Palacio, J. M. Paredes, Antonio Stamerra, Alessandro Carosi, Jose Miguel Miranda, F. Borracci, Anthony C. S. Readhead, Universitat de Barcelona, Aalto-yliopisto, Aalto University, Ahnen ML, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Banerjee B, Bangale P, de Almeida UB, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Buson S, Carosi A, Chatterjee A, Clavero R, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Lotto B, Wilhelmi ED, Di Pierro F, Doert M, Dominguez A, Prester DD, Dorner D, Doro M, Einecke S, Glawion DE, Elsaesser D, Ramazani VF, Fernandez-Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Giammaria P, Godinovic N, Munoz AG, Gora D, Guberman D, Hadasch D, Hahn A, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Hughes G, Idec W, Kodani K, Konno Y, Kubo H, Kushida J, La Barbera A, Lelas D, Lindfors E, Lombardi S, Longo F, Lopez M, Lopez-Coto R, Majumdar P, Makariev M, Mallot K, Maneva G, Manganaro M, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Moretti E, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo MN, Nilsson K, Nishijima K, Noda K, Nogues L, Orito R, Overkemping A, Paiano S, Palacio J, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Pedaletti G, Perri L, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Satalecka K, Schultz C, Schweizer T, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Torres DF, Toyama T, Treves A, Verguilov V, Vovk I, Ward JE, Will M, Wu MH, Zanin R, DAmmando F, Berdyugin A, Hovatta T, Max-Moerbeck W, Raiteri CM, Readhead ACS, Reinthal R, Richards JL, Verrecchia F, Villata M, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Buson, S., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Fallah Ramazani, V., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Giammaria, P., Godinović, N., González Muñoz, A., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, López, M., López Coto, R., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Nishijima, K., Noda, K., Nogués, L., Orito, R., Overkemping, A., Paiano, S., Palacio, J., Palatiello, Michele, Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Pedaletti, G., Perri, L., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Rodriguez Garcia, J., Saito, T., Satalecka, K., Schultz, C., Schweizer, T., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T, Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., D'Ammando, F., Berdyugin, A., Hovatta, T., Max Moerbeck, W., Raiteri, C. M., Readhead, A. C. S., Reinthal, R., Richards, J. L., Verrecchia, F., and Villata, M.

Subjects
galaxie [Gamma-rays], gamma-rays: galaxies, UPGRADE, Astrophysics, DETECTED BLAZARS, 01 natural sciences, LARGE-AREA TELESCOPE, law.invention, Raigs gamma, law, galaxies: active, BL Lacertae objects: individual: H1722+119, galaxies, distances and redshifts, BL LACERTAE OBJECTS, ALL-SKY SURVEY, MAGIC, TELESCOPES, LAC OBJECTS, SOURCE CATALOG, MAJOR, HELICAL JETS, CRAB-NEBULA, MAGIC (telescope), 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), distances and redshift [Galaxies], active BL Lacertae objects, individual, H1722+119 galaxies, distances and redshifts gamma-rays, Galaxies: active, Galaxies: distances and redshifts, Gamma-rays: galaxies, Astronomy and Astrophysics, Space and Planetary Science, galaxies [Gamma-rays], Extragalactic background light, Spectral energy distribution, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, BL Lac object, active [Galaxies], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Owens Valley Radio Observatory, Astrophysics::Cosmology and Extragalactic Astrophysics, Telescope, galaxies: active, BL Lacertae objects: individual: H1722+119, galaxies: distances and redshifts, gamma-rays: galaxies, 0103 physical sciences, individual: H1722+119 [BL Lacertae objects], distances and redshifts [Galaxies], ta115, 010308 nuclear & particles physics, Gamma rays, Astronomy, Astronomy and Astrophysic, Redshift, Crab Nebula, 13. Climate action, Galàxies actives, Active galaxies, ddc:520
Abstract

The MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes observed the BL Lac object H1722+119 (redshift unknown) for six consecutive nights between 2013 May 17 and 22, for a total of 12.5 h. The observations were triggered by high activity in the optical band measured by the KVA (Kungliga Vetenskapsakademien) telescope. The source was for the first time detected in the very high energy (VHE, $E > 100$ GeV) $\gamma$-ray band with a statistical significance of 5.9 $\sigma$. The integral flux above 150 GeV is estimated to be $(2.0\pm 0.5)$ per cent of the Crab Nebula flux. We used contemporaneous high energy (HE, 100 MeV $ < E < 100$ GeV) $\gamma$-ray observations from Fermi-LAT (Large Area Telescope) to estimate the redshift of the source. Within the framework of the current extragalactic background light models, we estimate the redshift to be $z = 0.34 \pm 0.15$. Additionally, we used contemporaneous X-ray to radio data collected by the instruments on board the Swift satellite, the KVA, and the OVRO (Owens Valley Radio Observatory) telescope to study multifrequency characteristics of the source. We found no significant temporal variability of the flux in the HE and VHE bands. The flux in the optical and radio wavebands, on the other hand, did vary with different patterns. The spectral energy distribution (SED) of H1722+119 shows surprising behaviour in the $\sim 3\times10^{14} - 10^{18}$ Hz frequency range. It can be modelled using an inhomogeneous helical jet synchrotron self-Compton model., Comment: 12 pages, 5 figures, 2 tables

Published
2016
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5. Insights into the emission of the blazar 1ES 1011+496 through unprecedented broadband observations during 2011 and 2012

Author

Daniela Dorner, E. Prandini, Iain A. Steele, Francesco Dazzi, M. Gaug, J. Herrera, A. Fernández-Barral, M. V. Fonseca, Koji Noda, Elisa Bernardini, E. Colombo, F. Di Pierro, S. Bonnefoy, M. Makariev, Talvikki Hovatta, Ivica Puljak, Pierre Colin, L. O. Takalo, D. Garrido Terrats, J. L. Richards, E. de Oña Wilhelmi, Roberta Zanin, Mosè Mariotti, A.-K. Overkemping, D. Eisenacher, E. Carmona, Markus Garczarczyk, J. Krause, B. De Lotto, Natalia Lewandowska, P. Da Vela, D. Nakajima, M. Hayashida, V. Scalzotto, U. Menzel, R. Reinthal, Juan Abel Barrio, Carole Mundell, Razmik Mirzoyan, U. Barres de Almeida, Abelardo Moralejo, Damir Lelas, K. Nishijima, Saverio Lombardi, P. G. Prada Moroni, Michele Palatiello, T. Schweizer, C. Delgado Mendez, T. Steinbring, P. Temnikov, D. Fidalgo, Anthony C. S. Readhead, Hanna Kellermann, M. I. Martínez, P. Bangale, Dorota Sobczyńska, A. De Angelis, A. Treves, Vitaly Neustroev, D. Dominis Prester, Francesco Longo, A. La Barbera, Juri Poutanen, Ana Babić, Stefano Ansoldi, Sabrina Einecke, S. R. Gozzini, Stefano Covino, Riccardo Paoletti, Nikola Godinovic, Benito Marcote, Elizaveta Rastorgueva-Foi, M. Strzys, Yusuke Konno, Y. Hanabata, Marc Ribó, J. Rodriguez Garcia, M. Nievas Rosillo, Jelena Aleksić, Kazuo Saito, J. Kushida, P. Antoranz, M. L. Knoetig, R. López-Coto, Diego F. Torres, G. Maneva, Antonio Stamerra, A. Niedzwiecki, Hidetoshi Kubo, S. N. Shore, X. Paredes-Fortuny, Jose Luis Contreras, Adrian Biland, Alessandro Carosi, W. Idec, David Sánchez, B. Biasuzzi, D. Tescaro, Tuomas Savolainen, David Paneque, P. Munar-Adrover, Julian Sitarek, K. Frantzen, J. Rico, I. Lozano, C. Fruck, T. Toyama, G. De Caneva, Juan Cortina, Anne Lähteenmäki, Oscar Blanch, K. Kodani, Masahiro Teshima, D. Hadasch, V. Kadenius, Elina Lindfors, Merja Tornikoski, Alexander B. Pushkarev, Daniel Mazin, Matthew L. Lister, Julia Thaele, Konstancja Satalecka, Louis Antonelli, Michele Doro, S. Paiano, Joni Tammi, F. D'Ammando, G. Bonnoli, K. Mallot, Karl Mannheim, Jose Miguel Miranda, R. J. García López, J. Hose, Massimo Persic, A. Sillanpää, D. Elsaesser, Takashi Saito, H. Takami, Eckart Lorenz, Alicia López-Oramas, V. Scapin, Reiko Orito, D. Galindo, J. Becerra González, Dario Hrupec, M. A. Lopez, F. Borracci, J. M. Paredes, A. González Mu. noz, Yuri Y. Kovalev, Kari Nilsson, S. Buson, M. Will, C. Arcaro, I. Snidaric, Thomas Bretz, L. Maraschi, Walter Max-Moerbeck, Tomislav Terzić, Wolfgang Rhode, Patrick Vogler, W. Bednarek, Fabrizio Tavecchio, Ll. Font, Aleksic J, Ansoldi S, Antonelli LA, Antoranz P, Arcaro C, Babic A, Bangale P, de Almeida UB, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Caneva G, De Lotto B, Wilhelmi ED, Mendez CD, Di Pierro F, Prester DD, Dorner D, Doro M, Einecke S, Eisenacher D, Elsaesser D, Fernandez-Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Godinovic N, Munoz AG, Gozzini SR, Hadasch D, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Idec W, Kadenius V, Kellermann H, Knoetig ML, Kodani K, Konno Y, Krause J, Kubo H, Kushida J, La Barbera A, Lelas D, Lewandowska N, Lindfors E, Lombardi S, Longo F, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Lozano I, Makariev M, Mallot K, Maneva G, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Munar-Adrover P, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo MN, Nilsson K, Nishijima K, Noda K, Orito R, Overkemping A, Paiano S, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Reinthal R, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Saito K, Satalecka K, Scalzotto V, Scapin V, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Torres DF, Toyama T, Treves A, Vogler P, Will M, Zanin R, Buson S, DAmmando F, Lateenmaki A, Hovatta T, Kovalev YY, Lister ML, Max-Moerbeck W, Mundell C, Pushkarev AB, Rastorgueva-Foi E, Readhead ACS, Richards JL, Tammi J, Sanchez DA, Tornikoski M, Savolainen T, Steele I, Autonomous University of Barcelona, University of Udine, INAF, Osservatorio Astronomico di Roma, University of Siena, University of Padova, University of Rijeka, Max Planck Institute for Physics, Centro Brasileiro de Pesquisas Físicas, Complutense University, University of Maryland, College Park, University of Łódź, Deutsches Elektronen-Synchrotron, Swiss Federal Institute of Technology Zurich, University of Würzburg, CIEMAT, Instituto de Astrofísica de Canarias, Institute of Space Studies of Catalonia, Technische Universität Dortmund, University of Barcelona, Kyoto University, Finnish MAGIC Consortium, Institute for Nuclear Research and Nuclear Energy, Japanese MAGIC Consortium, University of Turku, University of Pisa, Max-Planck-Institut für Physik, ICREA, University of Insubria, Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, Department of Radio Science and Engineering, California Institute of Technology, Lebedev Physical Institute, Purdue University, National Radio Astronomy Observatory Socorro, University of Liverpool, Crimean Astrophysical Observatory, Max Planck Institute for Radio Astronomy, Metsähovi Radio Observatory, Université Savoie Mont Blanc, Max-Planck-Institut für Radioastronomie, Aalto-yliopisto, Aalto University, Aleksić, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Arcaro, C, Babic, A., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., De Oña Wilhelmi, E., Delgado Mendez, C., Di Pierro, F., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Godinović, N., González Muñoz, A., Gozzini, S. R., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Knoetig, M. L., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Longo, Francesco, López, M., López Coto, R., López Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar Adrover, P., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palatiello, Michele, Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Reinthal, R., Rhode, W., Ribó, M., Rico, J., Rodriguez Garcia, J., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Vogler, P., Will, M., Zanin, R., Buson, S., D'Ammando, F., Lähteenmäki, A., Hovatta, T., Kovalev, Y. Y., Lister, M. L., Max Moerbeck, W., Mundell, C., Pushkarev, A. B., Rastorgueva Foi, E., Readhead, A. C. S., Richards, J. L., Tammi, J., Sanchez, D. A., Tornikoski, M., Savolainen, T., Steele, I., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and Universitat de Barcelona

Subjects
Photon, jets [galaxies], Astrophysics, 7. Clean energy, 01 natural sciences, LARGE-AREA TELESCOPE, law.invention, law, BL Lacertae objects: individual: 1ES 1011+496, galaxies: active, galaxies: jets, gamma rays: galaxies, radiation mechanisms: non-thermal, Astronomy and Astrophysics, Space and Planetary Science, individual: 1ES 1011+496 [BL Lacertae objects], 010303 astronomy & astrophysics, QC, QB, Physics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Superluminal motion, TEV BLAZARS, Polarization (waves), non-thermal [radiation mechanisms], Cosmology, BL-LACERTAE OBJECTS, ACTIVE GALACTIC NUCLEI, GAMMA-RAY EMISSION, X-RAY, LAC OBJECTS, MAGIC TELESCOPE, CRAB-NEBULA, ENERGY-DISTRIBUTION, active [galaxies], galaxies [gamma rays], Spectral energy distribution, Degree of polarization, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Telescope, 0103 physical sciences, galaxie [gamma rays], Blazar, Cosmologia, 010308 nuclear & particles physics, Astronomy and Astrophysic, Position angle, Galaxies, Galàxies, jet [galaxies], ddc:520, BL Lacertae objects: individual: 1ES 1011+496 – galaxies: active – galaxies: jets – radiation mechanisms: non-thermal – gamma rays: galaxies
Abstract

1ES 1011+496 $(z=0.212)$ was discovered in very high energy (VHE, E >100 GeV) $\gamma$-rays with MAGIC in 2007. The absence of simultaneous data at lower energies led to a rather incomplete characterization of the broadband spectral energy distribution (SED). We study the source properties and the emission mechanisms, probing whether a simple one-zone synchrotron-self-Compton (SSC) scenario is able to explain the observed broadband spectrum. We analyzed VHE to radio data from 2011 and 2012 collected by MAGIC, $Fermi$-LAT, $Swift$, KVA, OVRO, and Mets\"ahovi in addition to optical polarimetry data and radio maps from the Liverpool Telescope and MOJAVE. The VHE spectrum was fit with a simple power law with a photon index of $3.69\pm0.22$ and a flux above 150 GeV of $(1.46\pm0.16)\times10^{-11}$ ph cm$^{-2}$ s$^{-1}$. 1ES 1011+496 was found to be in a generally quiescent state at all observed wavelengths, showing only moderate variability from radio to X-rays. A low degree of polarization of less than 10% was measured in optical, while some bright features polarized up to 60% were observed in the radio jet. A similar trend in the rotation of the electric vector position angle was found in optical and radio. The radio maps indicated a superluminal motion of $1.8\pm0.4\,c$, which is the highest speed statistically significantly measured so far in a high-frequency-peaked BL Lac. For the first time, the high-energy bump in the broadband SED of 1ES 1011+496 could be fully characterized from 0.1 GeV to 1 TeV which permitted a more reliable interpretation within the one-zone SSC scenario. The polarimetry data suggest that at least part of the optical emission has its origin in some of the bright radio features, while the low polarization in optical might be due to the contribution of parts of the radio jet with different orientations of the magnetic field to the optical emission., Comment: 14 pages, 7 figures

Published
2016
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6. Probing the very high energy gamma-ray spectral curvature in the blazar PG 1553+113 with the MAGIC telescopes

Author

Aleksi , J., Poutanen, J., Godinovi , N., Gonzalez Munoz, A., Gozzini, S. R., Bangale, P., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hildebrand, D., Hose, J., Prada Moroni, P. G., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Barrio, J. A., Knoetig, M. L., Kodani, K., Konno, Y., Krause, J., Kubo, H., Prandini, E., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Becerra Gonzalez, J., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Puljak, I., Lopez-Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Bednarek, W., Mannheim, K., Maraschi, L., Marcote, B., Biland, A., Mariotti, M., Martinez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Bernardini, E., Munar-Adrover, P., Nakajima, D., Reinthal, R., Neustroev, V., Niedzwiecki, A., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Rhode, W., Ribo, M., Rico, J., Rodriguez Garcia, J., Ansoldi, S., Rugamer, S., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Blanch, O., Scapin, V., Schultz, C., Schweizer, T., Sillanpaa, A., Biasuzzi, B., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamerra, A., Steinbring, T., Bonnefoy, S., Storz, J., Strzys, M., Takalo, L., Palatiello, M., Takami, H., Tavecchio, F., Temnikov, P., Terzi , T., Tescaro, D., Teshima, M., Thaele, J., Bonnoli, G., Tibolla, O., Torres, D. F., Paneque, D., Toyama, T., Treves, A., Vogler, P., Will, M., Zanin, R., D'Ammando, F., Buson, S., Lahteenmaki, A., Borracci, F., Tornikoski, M., Paoletti, R., Hovatta, T., Readhead, A. C. S., Max-Moerbeck, W., Richards, J. L., MAGIC Collaboration, Fermi-LAT Collaboration, Bretz, T., Carmona, E., Carosi, A., Colin, P., Paredes, J. M., Antonelli, L. A., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., Paredes-Fortuny, X., de Ona Wilhelmi, E., Antoranz, P., Delgado Mendez, C., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fidalgo, D., Persic, M., Fonseca, M. V., Font, L., Babic, A., Frantzen, K., Fruck, C., Galindo, D., Garcia Lopez, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Anne Lähteenmäki Group, Department of Radio Science and Engineering, Aalto-yliopisto, Aalto University, Aleksic J, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Bangale P, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Caneva G, De Lotto B, Wilhelmi ED, Mendez CD, Prester DD, Dorner D, Doro M, Einecke S, Eisenacher D, Elsaesser D, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Loez RJG, Garczarczyk M, Terrats DG, Gaug M, Godinovic N, Munoz AG, Gozzini SR, Hadasch D, Hanabata Y, Hayashida M, Herrera J, Hildebrand D, Hose J, Hrupec D, Idec W, Kadenius V, Kellermann H, Knoetig ML, Kodani K, Konno Y, Krause J, Kubo H, Kushida J, La Barbera A, Lelas D, Lewandowska N, Lindfors E, Lombardi S, Longo F, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Lozano I, Makariev M, Mallot K, Maneva G, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Munar-Adrover P, Nakajima D, Neustroev V, Niedzwiecki A, Nilsson K, Nishijima K, Noda K, Orito R, Overkemping A, Paiano S, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Reinthal R, Rhode W, Ribo M, Rico J, Garcia JR, Rugamer S, Saito T, Saito K, Satalecka K, Scalzotto V, Scapin V, Schultz C, Schweizer T, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Spanier F, Stamerra A, Steinbring T, Storz J, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Tibolla O, Torres DF, Toyama T, Treves A, Vogler P, Will M, Zanin R, DAmmando F, Buson S, Lahteenmaki A, Tornikoski M, Hovatta T, Readhead ACS, Max-Moerbeck W, Richards JL, School services, ELEC, Metsähovi Radio Observatory, Aleksi , J., Ansoldi, Stefano, Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., de Ona Wilhelmi, E., Delgado Mendez, C., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., Garcia Lopez, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Godinovi , N., Gonzalez Munoz, A., Gozzini, S. R., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hildebrand, D., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Knoetig, M. L., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Longo, Francesco, Lopez, M., Lopez Coto, R., Lopez Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martinez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar Adrover, P., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rodriguez Garcia, J., Rugamer, S., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Sillanpaa, A., Sitarek, J., Snidaric, I., Sobczynska, D., Spanier, F., Stamerra, A., Steinbring, T., Storz, J., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzi , T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Vogler, P., Will, M., Zanin, R., Collaboration), (The M., D'Ammando, F., Buson, S., Lahteenmaki, A., Tornikoski, M., Hovatta, T., Readhead, A. C. S., Max Moerbeck, W., and Richards, J. L.

Subjects
gamma-rays: galaxies, Astrophysics, cosmic background radiation, MAGIC (telescope), Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, ta213, 213 Electronic, automation and communications engineering, electronics, gamma rays: observations, blazar, BL Lac: AGNs: individual (PG 1553 + 113), individual: PG1553+113 [BL Lacertae objects], Extragalactic background light, active [galaxies], Spectral energy distribution, Electrónica, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, BL Lac object, general [gamma-rays], 1171 Geosciences, Astrophysics and Astronomy, Astrophysics::High Energy Astrophysical Phenomena, ta221, galaxies: active, Cosmic background radiation, ta1171, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, active, BL Lacertae objects: general, BL Lacertae objects: individual: PG1553+113, cosmic background radiation, gamma-rays: galaxies, gamma-rays: general [galaxies], 114 Physical sciences, Blazar, galaxies: active, BL Lacertae objects: general, BL Lacertae objects: individual: PG1553+113, cosmic background radiation, gamma-rays: galaxies, gamma-rays: general, ta216, BL Lacertae objects: individual: PG1553+113, ta115, ta114, general [BL Lacertae objects], 221 Nanotechnology, Astronomy, Astronomy and Astrophysics, BL Lacertae objects: general, gamma-rays: general, Redshift, Galaxies: active, Gamma-rays: galaxies, Gamma-rays: general, Space and Planetary Science, galaxies [gamma-rays], 115 Astronomy and space science, 216 Materials engineering, Intergalactic travel, ddc:520
Abstract

PG 1553+113 is a very-high-energy (VHE, $E>100\,\mathrm{GeV}$) $\gamma$-ray emitter classified as a BL Lac object. Its redshift is constrained by intergalactic absorption lines in the range $0.4, Comment: 13 pages, 7 figures, accepted for publication in MNRAS

Published
2015
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7. First broadband characterization and redshift determination of the VHE blazar MAGIC J2001+439

Author

Robert Wagner, Konstancja Satalecka, Michele Doro, K. Nishijima, K. Mallot, R. J. García López, A. Herrero, D. Dominis Prester, M. Uellenbeck, Nina Nowak, J. M. Paredes, A. López-Oramas, J. Kushida, Antonio Stamerra, Jelena Aleksić, Nikola Godinovic, Benito Marcote, Jose Luis Contreras, A. Niedzwiecki, David Paneque, Wlodek Bednarek, Alessandro Carosi, Francisco Prada, J. L. Richards, Juan Cortina, K. Kodani, Ruben Lopez-Coto, Massimo Persic, D. Nakajima, J. Storz, D. Garrido Terrats, Talvikki Hovatta, Patrick Vogler, P. G. Prada Moroni, Valeri M. Larionov, Jose Miguel Miranda, V. Scalzotto, C. Schultz, V. Scapin, Tomislav Terzić, Yusuke Konno, Anthony C. S. Readhead, J. Krause, O. Tibolla, M. Hayashida, B. De Lotto, P. Da Vela, Ana Babić, Hanna Kellermann, L. Maraschi, Elina Lindfors, Kari Nilsson, Daniel Mazin, Marc Ribó, M. V. Fonseca, P. Bangale, Julia Thaele, Hidetoshi Kubo, Stefano Covino, U. Menzel, Emanuele Paolo Farina, A. De Angelis, D. Tescaro, M. Perri, I. Snidaric, Natalia Lewandowska, M. Palatiello, Diego F. Torres, S. Rügamer, Stefano Ansoldi, Juan Abel Barrio, M. I. Martínez, Riccardo Paoletti, Felix Spanier, T. Sakamoto, M. Garczarczyk, E. Lorenz, Hajime Takami, A. La Barbera, L. A. Antonelli, Francesco Dazzi, Sabrina Einecke, P. Antoranz, R. Reinthal, J. Rodriguez Garcia, Dominik Elsaesser, Giacomo Bonnoli, X. Paredes-Fortuny, U. Barres de Almeida, I. Lozano, Fabrizio Tavecchio, Damir Lelas, Ll. Font, Masahiro Teshima, Victor Stamatescu, S. Bonnefoy, R. D. Schwartz, Filippo D'Ammando, Dorota Sobczyńska, R. Mirzoyan, D. Eisenacher, Abelardo Moralejo, P. Temnikov, Fabio Zandanel, Shan Sun, E. Carmona, T. Steinbring, Julian Sitarek, J. Hose, Aaron Dominguez, E. Prandini, Daniela Hadasch, T. Toyama, Aldo Treves, W. Idec, Thomas Bretz, S. N. Shore, Walter Max-Moerbeck, Wolfgang Rhode, K. Frantzen, Ivica Puljak, Tihomir Surić, Pierre Colin, D. Carreto Fidalgo, T. Schweizer, C. Delgado Mendez, S. R. Gozzini, F. Borracci, V. Kadenius, S. Paiano, Karl Mannheim, J. Becerra González, Mario Meucci, F. Verrecchia, E. Colombo, Nijil Mankuzhiyil, P. Munar-Adrover, G. Maneva, Silvia Preziuso, L. O. Takalo, R. Zanin, A. Saggion, Adrian Biland, A. González Muñoz, Mosè Mariotti, A.-K. Overkemping, J. Rico, A. Sillanpää, Daniela Dorner, Takashi Saito, Saverio Lombardi, M. Gaug, Reiko Orito, J. Herrera, Koji Noda, Elisa Bernardini, Christian Fruck, K. Saito, D. Hildebrand, Daniel Ferenc, G. De Caneva, S. Partini, Marcel Strzys, L. C. Reyes, Martin Makariev, Oscar Blanch, M. Doert, Dario Hrupec, M. A. Lopez, Aleksic J, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Bangale P, de Almeida UB, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Fidalgo DC, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Caneva G, De Lotto B, Mendez CD, Doert M, Dominguez A, Prester DD, Dorner D, Doro M, Einecke S, Eisenacher D, Elsaesser D, Farina E, Ferenc D, Fonseca MV, Font L, Frantzen K, Fruck C, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Godinovic N, Munoz AG, Gozzini SR, Hadasch D, Hayashida M, Herrera J, Herrero A, Hildebrand D, Hose J, Hrupec D, Idec W, Kadenius V, Kellermann H, Kodani K, Konno Y, Krause J, Kubo H, Kushida J, La Barbera A, Lelas D, Lewandowska N, Lindfors E, Lombardi S, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Lozano I, Makariev M, Mallot K, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Meucci M, Miranda JM, Mirzoyan R, Moralejo A, Munar-Adrover P, Nakajima D, Niedzwiecki A, Nilsson K, Nishijima K, Noda K, Nowak N, Orito R, Overkemping A, Paiano S, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Partini S, Persic M, Prada F, Moroni PGP, Prandini E, Preziuso S, Puljak I, Reinthal R, Rhode W, Riboo M, Rico J, Garcia JR, Rugamer S, Saggion A, Saito T, Saito K, Satalecka K, Scalzotto V, Scapin V, Schultz C, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Spanier F, Stamatescu V, Stamerra A, Steinbring T, Storz J, Strzys M, Sun S, Suric T, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Tibolla O, Torres DF, Toyama T, Treves A, Uellenbeck M, Vogler P, Wagner RM, Zandanel F, Zanin R, DAmmando F, Hovatta T, Larionov VM, Max-Moerbeck W, Perri M, Readhead ACS, Richards JL, Sakamoto T, Schwartz RD, Verrecchia F, and Reyes LC

Subjects
ACTIVE GALACTIC NUCLEI, BL Lacertae objects: individual: MAGIC J2001+439, Galaxies: active, BL Lac objects: individual (MAGIC J2001+435), gamma rays: observations, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, LARGE-AREA TELESCOPE, Nordic Optical Telescope, Spectral line, BL Lacertae objects: individual: MAGIC J2001+435, Gamma rays: galaxies, 0103 physical sciences, GAMMA-RAY SPECTRUM, MAGIC (telescope), 010306 general physics, Blazar, 010303 astronomy & astrophysics, Physics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), galaxies: active – BL Lacertae objects: individual: MAGIC J2001+435 – BL Lacertae objects: individual: MAGIC J2001+439 – gamma rays: galaxies, FERMI ERA, Astronomy and Astrophysics, PKS 1424+240, BL-LACERTAE OBJECTS, Galaxy, Redshift, EXTRAGALACTIC BACKGROUND LIGHT, LAC OBJECTS, SKY SURVEY, RADIATION, Amplitude, Space and Planetary Science, ddc:520, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, BL Lac object
Abstract

We aim to characterize the broadband emission from 2FGL J2001.1+4352, which has been associated with the unknown-redshift blazar MG4 J200112+4352. Based on its gamma-ray spectral properties, it was identified as a potential very high energy (VHE; E > 100 GeV) gamma-ray emitter. The source was observed with MAGIC first in 2009 and later in 2010 within a multi-instrument observation campaign. The MAGIC observations yielded 14.8 hours of good quality stereoscopic data. The object was monitored at radio, optical and gamma-ray energies during the years 2010 and 2011. The source, named MAGIC J2001+439, is detected for the first time at VHE with MAGIC at a statistical significance of 6.3 {\sigma} (E > 70 GeV) during a 1.3-hour long observation on 2010 July 16. The multi-instrument observations show variability in all energy bands with the highest amplitude of variability in the X-ray and VHE bands. We also organized deep imaging optical observations with the Nordic Optical Telescope in 2013 to determine the source redshift. We determine for the first time the redshift of this BL Lac object through the measurement of its host galaxy during low blazar activity. Using the observational evidence that the luminosities of BL Lac host galaxies are confined to a relatively narrow range, we obtain z = 0.18 +/- 0.04. Additionally, we use the Fermi-LAT and MAGIC gamma-ray spectra to provide an independent redshift estimation, z = 0.17 +/- 0.10. Using the former (more accurate) redshift value, we adequately describe the broadband emission with a one-zone SSC model for different activity states and interpret the few-day timescale variability as produced by changes in the high-energy component of the electron energy distribution., Comment: 17 pages, 15 figures, Accepted for publication in A&A

Published
2014
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8. MAGIC gamma-ray and multi-frequency observations of flat spectrum radio quasar PKS 1510-089 in early 2012

Author

Aleksic, J., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., Bednarek, W., Bernardini, E., Biland, A., Blanch, O., Bonnefoy, S., Contreras, J. L., Paneque, D., Paoletti, R., Cortina, J., Paredes, J. M., Covino, S., Paredes-Fortuny, X., Da, Vela P., Partini, S., Dazzi, F., Persic, M., De, Angelis A., Prada, F., De, Caneva G., PradaMoroni, P. G., De, Lotto B., Prandini, E., Delgado, Mendez C., Preziuso, S., Doert, M., Bonnoli, G., Dominguez, A., Puljak, I., Reinthal, R., Dominis, Prester D., Rhode, W., Dorner, D., Ribo, M., Doro, M., Rico, J., Einecke, S., Eisenacher, D., Elsaesser, D., Farina, E., Ferenc, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Garcia, Lopez R. J., Rodriguez, Garcia J., Garczarczyk, M., Garrido, Terrats D., Gaug, M., Godinovic, N., Gonzalez, Munoz A., Gozzini, S. R., Hadasch, D., Herrera, J., Herrero, A., Rugamer, S., Hildebrand, D., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Kodani, K., Konno, Y., Krause, J., Kubo, H., Saggion, A., Kushida, J., La, Barbera A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Lorenz, E., Saito, T., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mankuzhiyil, N., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martinez, M., Saito, K., Mazin, D., Menzel, U., Meucci, M., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar-Adrover, P., Nakajima, D., Niedzwiecki, A., Nilsson, K., Borracci, F., Nishijima, K., Noda, K., Nowak, N., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, S. N., Sillanpaa, A., Sitarek, J., Snidaric, I., Sobczynska, D., Bretz, T., Spanier, F., Stamatescu, V., Stamerra, A., Steinbring, T., Storz, J., Strzys, M., Sun, S., Suric, T., Takalo, L., Takami, H., Carmona, E., Tavecchio, F., Temnikov, P., Terzic, T., Tescaro, D., Teshima, M., Thaele, J., Tibolla, O., Torres, D. F., Toyama, T., Treves, A., Carosi, A., Uellenbeck, M., Vogler, P., Wagner, R. M., Zandanel, F., Zanin, R., Lucarelli, F., Pittori, C., Vercellone, S., Verrecchia, F., Buson, S., Carreto, Fidalgo D., D'Ammando, F., Stawarz, Lukasz, Colin, P., Colombo, E., Hayashida, Masaaki, Barres, de Almeida U., Barrio, J. A., Becerra, Gonzalez J., Department of Radio Science and Engineering, Aalto-yliopisto, Aalto University, Aleksic J, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Bangale P, de Almeida UB, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bratz T, Carmona E, Carosi A, Fidalgo DC, Colin P, Colombo E, Contreras JL, Cortina I, Covino S, Da Vela P, Dazzi F, De Angelis A, De Caneva G, De Lotto B, Mendez CD, Doert M, Dominguez A, Presters DD, Dorner D, Doro M, Einecke S, Eisenacher D, Elsaesser D, Farina E, Ferenc D, Fonseca MV, Font L, Frantzen K, Fruck C, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Godinovic N, Munoz AG, Gozzini SR, Hadasch D, Hayashida M, Herrera J, Herrero A, Hildebrand D, Hose J, Hrupec D, Idec W, Kadenius V, Kellermann H, Kodani K, Konno Y, Krause J, Kubo H, Kushida J, La Barbera A, Lelas D, Lewandowska N, Lindfors E, Lombardi S, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Lozano I, Makariev M, Mallotw K, Maneva G, Mankuzhiyil N, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Meucci M, Miranda JM, Mirzoyan R, Moralejo A, Munar-Adrover P, Nakajima D, Niedzwiecki A, Nilsson K, Nishijima K, Noda K, Nowak N, Orito R, Overkemping A, Paiano S, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Partini S, Persic M, Prada F, Moroni PGP, Prandini E, Preziuso S, Puljak I, Reinthal R, Rhode W, Ribo M, Rico J, Garcia JR, Rugamer S, Saggion A, Saito T, Saito K, Satalecka K, Scalzotto V, Scapin V, Schultz C, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Spanier F, Stamatescu V, Stamerra A, Steinbring T, Storz J, Strzys M, Sun S, Suric T, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Tibolla O, Torres DF, Toyama T, Treves A, Uellenbeck M, Vogler P, Wagner RM, Zandanel F, Zanin R, Lucarelli F, Pittori C, Vercellone S, Verrecchia F, Buson S, DAmmando F, Stawarz L, Giroletti M, Orienti M, Mundell C, Steele I, Zarpudin B, Raiteri CM, Villata M, Sandrinelli A, Lahteenmaki A, Tammi J, Tornikoski M, Hovatta T, Readhead ACS, Max-Moerbeck W, Richards JL, Jorstad S, Marscher A, Gurwell MA, Larionov VM, Blinov DA, Konstantinova TS, Kopatskaya EN, Larionova LV, Earionova EG, Morozova DA, Troitky IS, Mokrushina AA, Pavlova YV, Chen WP, Lin HC, Panwar N, Agudo I, Casadio C, Gomez JL, Molina SN, Kurtanidze OM, Nikolashvili MG, Kurtanidze SO, Chigladze RA, Acosta-Pulido JA, Carnerero MI, Manilla-Robles A, Ovcharov E, Bozhilov V, Metodieva I, Aller MF, Aller HD, Fuhrman L, Angelakis E, Nestoras I, Krichbaue TP, Zensue JA, Ungerechts H, and Sievers A

Subjects
ACTIVE GALACTIC NUCLEI, LARGE-AREA TELESCOPE, HIGH-ENERGY EMISSION, BASE-LINE ARRAY, BLAZAR 3C 279, MULTIWAVELENGTH OBSERVATIONS, X-RAY, POLARIMETRIC OBSERVATIONS, BACKGROUND-RADIATION, HIGH-FREQUENCIES, galaxies [Gamma rays], galaxies: active, galaxies: jets, gamma rays: galaxies, quasars: individual: PKS1510-089, Astrophysics, 01 natural sciences, QD, MAGIC (telescope), 010303 astronomy & astrophysics, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Physics, Galaxies: active, Gamma rays: galaxies, Spectral energy distribution, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, Galaxies: jets, Quasars: individual: PKS 1510-089, Astronomy and Astrophysics, Space and Planetary Science, active [Galaxies], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, galaxies: active / galaxies: jets / gamma rays: galaxies / quasars: individual: PKS 1510-089, Radio spectrum, 0103 physical sciences, individual: PKS 1510-089 [Quasars], Blazar, Very Long Baseline Array, 010308 nuclear & particles physics, Compton scattering, Quasar, ddc:520, jets [Galaxies], Fermi Gamma-ray Space Telescope
Abstract

著者人数: 219名, Accepted: 2014-05-30, 資料番号: SA1140143000

Published
2014
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9. VERY HIGH ENERGY γ -RAYS FROM THE UNIVERSE’S MIDDLE AGE: DETECTION OF THE z = 0.940 BLAZAR PKS 1441+25 WITH MAGIC

Author

M. Pesce Rollins, Lluis Font, Francesco Longo, Abelardo Moralejo, I. Snidaric, Thomas Bretz, M. Feige, E. Moretti, Mosè Mariotti, A.-K. Overkemping, M. Makariev, D. Wolfert, E. Lorenz, Max Ludwig Ahnen, S. Haarto, P. Giammaria, T. Steinbring, S. Maldera, F. de Palma, D. Dominis Prester, Nicola Omodei, Marcel Strzys, P. Haeusner, R. Clavero, W. Bednarek, Fabrizio Tavecchio, R. Reinthal, R. Zanin, Elina Lindfors, D. Nakajima, Daniela Dorner, Adrian Biland, P. G. Prada Moroni, R. A. Cameron, M. Gaug, M. Caragiulo, Johan Bregeon, Saverio Lombardi, Kyoshi Nishijima, Arka Chatterjee, D. Fidalgo, U. Barres de Almeida, Damir Lelas, J. Kushida, Daniel Mazin, Igor V. Moskalenko, Olaf Reimer, Julie McEnery, Anne Lähteenmäki, Hiromitsu Takahashi, Julian Sitarek, A. López Oramas, J. Herrera, Wolfgang Rhode, J. Rico, J. Klamt, Dorota Sobczyńska, Jose Luis Contreras, Hiroyasu Tajima, X. Paredes Fortuny, Koji Noda, J. Li, A. Niedzwiecki, Masahiro Teshima, P. Bruel, E. Orlando, Yusuke Konno, T. Toyama, E. Recillas, V. Fallah Ramazani, Elisa Bernardini, K. S. Wood, Carmelo Sgrò, Riccardo Rando, Nikola Godinovic, T. Ohsugi, Eleonora Troja, Juan Cortina, D. J. Thompson, F. Di Pierro, Benito Marcote, P. Fusco, E. Colombo, Stefano Ansoldi, Ievgen Vovk, Oscar Blanch, N. Zottmann, E. Hays, Talvikki Hovatta, Riccardo Paoletti, M. Razzano, Ivica Puljak, E. Nuss, David Paneque, C. Delgado Mendez, Filippo D'Ammando, F. Piron, Pierre Colin, B. De Lotto, Stefano Covino, A. De Angelis, Luigi Pacciani, A. Treves, Vitaly Neustroev, T. Schweizer, M. Kuss, R. Bonino, J. Palacio, R. Mirzoyan, I. A. Grenier, P. Temnikov, Stefano Ciprini, E. de Oña Wilhelmi, Nestor Mirabal, P. Da Vela, L. Carrasco, Marcello Giroletti, L. O. Takalo, D. Guberman, M. I. Martínez, J. M. Paredes, E. Cavazzuti, M. Mayer, Juri Poutanen, S. Rainò, Antonio Stamerra, F. Borracci, Tsunefumi Mizuno, Y. Hanabata, A. González Muñoz, G. Maneva, Marina Manganaro, P. Spinelli, S. Bonnefoy, Kari Nilsson, T. A. Porter, Gloria Spandre, J. Hose, P. Antoranz, Tomoki Saito, D. Tescaro, D. Galindo, U. Menzel, E. Prandini, M. Will, G. Chiaro, Marco Ajello, J. B. Thayer, Merja Tornikoski, F. Loparco, Markus Garczarczyk, Francesco Giordano, B. Banerjee, Sabrina Einecke, D. Elsaesser, J. W. Hewitt, R. Desiante, D. Garrido Terrats, A. Fernández Barral, Diego F. Torres, James Chiang, H. Takami, M. Palatiello, S. Buson, Alessandro Carosi, J. Rodriguez Garcia, P. Lubrano, Mislav Baloković, A. Carraminana, Konstancja Satalecka, A. Sillanpää, L. Di Venere, Dario Gasparrini, Michele Doro, Roger Blandford, Vassil Verguilov, Roopesh Ojha, L. Maraschi, Francesco Dazzi, Ana Babić, Gareth Hughes, F. Spada, Julia Thaele, Tomislav Terzić, A. Porras, M. E. Monzani, A. Morselli, Jose Miguel Miranda, G. A. Caliandro, A. Reimer, W. Idec, A. Hahn, E. Carmona, Stefan Larsson, J. Kania, M. Hayashida, Wu M. H., Steven N. Shore, C. Lorey, Marc Ribó, P. Bangale, E. J. Siskind, Hidetoshi Kubo, Dario Hrupec, M. A. Lopez, G. Bonnoli, F. Gargano, K. Mallot, R. J. García López, R. Lopez Coto, Massimo Persic, V. H. Chavushyan, Liang Li, Guido Barbiellini, J. León Tavares, Pratik Majumdar, M. V. Fonseca, K. Kodani, Reiko Orito, Aaron Dominguez, Juan Abel Barrio, Luca Baldini, J. E. Ward, Sylvain Guiriec, Mn Mazziotta, Christian Fruck, J. S. Perkins, Nicola Giglietto, B. Biasuzzi, M. N. Lovellette, P. A. Caraveo, J. Becerra González, Elisabetta Bissaldi, G. Pivato, Andrei Berdyugin, T. Jogler, Ronaldo Bellazzini, C. Schultz, Louis Antonelli, K. Frantzen, Denis Bastieri, S. Paiano, Karl Mannheim, A. La Barbera, D. Eisenacher Glawion, M. Nievas Rosillo, Universitat de Barcelona, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ITA, USA, GBR, FRA, DEU, ESP, AFG, ALB, DZA, AND, AGO, BGR, BFA, BDI, KHM, CMR, CAN, CPV, CS, TCD, CYM, COD, CHL, TWN, CYP, VAT, COL, COM, COG, PRK, KOR, CIV, DOM, CCK, CRI, HRV, CUB, DNK, DMA, ECU, EGY, SLV, ARE, CHN, ERI, AIA, EST, ETH, FJI, PHL, FIN, GAB, GMB, GAZA, ZAF, GEO, COK, GHA, JAM, JPN, GIB, DJI, JOR, GRC, REU, GRD, GRL, GLP, FRO, GUM, GTM, GIN, GNB, GNQ, GUI, ROU, GUY, GUF, HTI, HND, FLK, HKG, IND, IDN, IRN, MNP, RWA, MHL, MUS, UMI, SLB, TCA, VIR, ATA, VGB, ISR, KAZ, RUS, KGZ, KIR, SCG, KWT, LAO, LSO, LVA, ATG, LBN, LBR, ESH, LBY, LIE, LTU, LUX, MAC, MKD, MDG, MWI, ANT, MDV, AUS, MYS, MLI, MLT, MAR, MTQ, MRT, MYT, MEX, MDA, SAU, IRQ, MCO, MNG, MSR, MOZ, MMR, NAM, NRU, NPL, NIC, NER, KNA, ARG, NGA, NIU, NOR, NCL, NZL, OMN, NLD, PAK, PLW, SPM, PAN, ARM, PNG, PRY, PER, PCN, PYF, POL, PRI, PRT, VCT, QAT, CZE, ABW, CAF, ASM, WSM, SMR, LCA, SHN, STP, SEN, IRL, AUT, SYC, SLE, SGP, SYR, SVK, SVN, SOM, LKA, ISL, FSM, AZE, SGS, SDN, SUR, SJM, SWE, CHE, SWZ, TJK, BVT, TZA, IOT, BHS, ATF, PSE, THA, TLS, TGO, TKL, TON, MAN, TTO, TUN, TUR, BHR, TKM, TUV, UKR, UGA, HUN, URY, CXR, UZB, VUT, VEN, VNM, BGD, WLF, YEM, ZMB, ZWE, BRB, HMD, BEL, BLZ, BEN, BMU, BTN, BLR, BOL, BIH, BWA, BRA, NFK, BRN, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Banerjee, B., Bangale, P., De Almeida, U. Barre, Barrio, J. A., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Mendez, C. Delgado, Di Pierro, F., Prester, D. Domini, Dorner, D., Doro, M., Einecke, S., Glawion, D. Eisenacher, Elsaesser, D., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., López, R. J. García, Garczarczyk, M., Terrats, D. Garrido, Gaug, M., Giammaria, P., Godinović, N., Muñoz, A. González, Guberman, D., Hahn, A., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., López, M., López Coto, R., López Oramas, A., Lorenz, E., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Rosillo, M. Nieva, Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Persic, M., Poutanen, J., Moroni, P. G. Prada, Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Garcia, J. Rodriguez, Saito, T., Satalecka, K., Schultz, C., Schweizer, T., Shore, S. N., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., Ajello, M., Baldini, L., Barbiellini, G., Bastieri, D., González, J. Becerra, Bellazzini, R., Bissaldi, E., Blandford, R. D., Bonino, R., Bregeon, J., Bruel, P., Buson, S., Caliandro, G. A., Cameron, R. A., Caragiulo, M., Caraveo, P. A., Cavazzuti, E., Chiang, J., Chiaro, G., Ciprini, S., D'Ammando, F., De Palma, F., Desiante, R., Di Venere, L., Domínguez, A., Fusco, P., Gargano, F., Gasparrini, D., Giglietto, N., Giordano, F., Giroletti, M., Grenier, I. A., Guiriec, S., Hays, E., Hewitt, J. W., Jogler, T., Kuss, M., Larsson, S., Li, J., Li, L., Longo, Francesco, Loparco, F., Lovellette, M. N., Lubrano, P., Maldera, S., Mayer, M., Mazziotta, M. N., Mcenery, J. E., Mirabal, N., Mizuno, T., Monzani, M. E., Morselli, A., Moskalenko, I. V., Nuss, E., Ojha, R., Ohsugi, T., Omodei, N., Orlando, E., Perkins, J. S., Pesce Rollins, M., Piron, F., Pivato, G., Porter, T. A., Raino, S., Rando, R., Razzano, M., Reimer, A., Reimer, O., Sgro, C., Siskind, E. J., Spada, F., Spandre, G., Spinelli, P., Tajima, H., Takahashi, H., Thayer, J. B., Thompson, D. J., Troja, E., Wood, K. S., Balokovic, M., Berdyugin, A., Carraminana, A., Carrasco, L., Chavushyan, V., Ramazani, V. Fallah, Feige, M., Haarto, S., Haeusner, P., Hovatta, T., Kania, J., Klamt, J., Lähteenmäki, A., Leon Tavares, J., Lorey, C., Pacciani, L., Porras, A., Recillas, E., Reinthal, R., Tornikoski, M., Wolfert, D., Zottmann, N., Ahnen ML, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Banerjee B, Bangale P, De Almeida UB, Barrio JA, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Carmona E, Carosi A, Chatterjee A, Clavero R, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Lotto B, Wilhelmi ED, Mendez CD, Di Pierro F, Prester DD, Dorner D, Doro M, Einecke S, Glawion DE, Elsaesser D, Fernandez-Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Giammaria P, Godinovic N, Munoz AG, Guberman D, Hahn A, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Hughes G, Idec W, Kodani K, Konno Y, Kubo H, Kushida J, La Barbera A, Lelas D, Lindfors E, Lombardi S, Lopez M, Lopez-Coto R, Lopez-Oramas A, Lorenz E, Majumdar P, Makariev M, Mallot K, Maneva G, Manganaro M, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Moretti E, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo M, Nilsson K, Nishijima K, Noda K, Orito R, Overkemping A, Paiano S, Palacio J, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Satalecka K, Schultz C, Schweizer T, Shore SN, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Torres DF, Toyama T, Treves A, Verguilov V, Vovk I, Ward JE, Will M, Wu MH, Zanin R, Ajello M, Baldini L, Barbiellini G, Bastieri D, Gonzalez JB, Bellazzini R, Bissaldi E, Blandford RD, Bonino R, Bregeon J, Bruel P, Buson S, Caliandro GA, Cameron RA, Caragiulo M, Caraveo PA, Cavazzuti E, Chiang J, Chiaro G, Ciprini S, DAmmando F, de Palma F, Desiante R, Di Venere L, Dominguez A, Fusco P, Gargano F, Gasparrini D, Giglietto N, Giordano F, Giroletti M, Grenier IA, Guiriec S, Hays E, Hewitt JW, Jogler T, Kuss M, Larsson S, Li J, Li L, Longo F, Loparco F, Lovellette MN, Lubrano P, Maldera S, Mayer M, Mazziotta MN, McEnery JE, Mirabal N, Mizuno T, Monzani ME, Morselli A, Moskalenko IV, Nuss E, Ojha R, Ohsugi T, Omodei N, Orlando E, Perkins JS, Pesce-Rollins M, Piron F, Pivato G, Porter TA, Raino S, Rando R, Razzano M, Reimer A, Reimer O, Sgro C, Siskind EJ, Spada F, Spandre G, Spinelli P, Tajima H, Takahashi H, Thayer JB, Thompson DJ, Troja E, Wood KS, Balokovic M, Berdyugin A, Carraminana A, Carrasco L, Chavushyan V, Ramazani VF, Feige M, Haarto S, Haeusner P, Hovatta T, Kania J, Klamt J, Lahteenmaki A, Leon-Tavares J, Lorey C, Pacciani L, Porras A, Recillas E, Reinthal R, Tornikoski M, Wolfert D, and Zottmann N

Subjects
individual (PKS 1441+25) [quasars], cosmic background radiation, Astrophysics, 7. Clean energy, Raigs gamma, Jets (Astrofísica), galaxies: active, galaxies: jets, gamma rays: galaxies, quasars: individual (PKS 1441+25), MAGIC (telescope), Space and Planetary Science, Astronomy and Astrophysics, ComputingMilieux_MISCELLANEOUS, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Extragalactic background light, active [galaxies], Spectral energy distribution, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], cosmic background radiation – galaxies: active – galaxies: jets – gamma rays: galaxies – quasars: individual (PKS 1441+25), galaxie [gamma rays], Blazar, Quasars, Quàsars, Gamma rays, Quasar, Astrophysics - Astrophysics of Galaxies, Redshift, Galaxy, Astrophysical jets, jet [galaxies], 13. Climate action, Astrophysics of Galaxies (astro-ph.GA), Galàxies actives, Active galaxies, ddc:520, Fermi Gamma-ray Space Telescope
Abstract

The flat-spectrum radio quasar PKS 1441+25 at a redshift of z = 0.940 is detected between 40 and 250 GeV with a significance of 25.5 {\sigma} using the MAGIC telescopes. Together with the gravitationally lensed blazar QSO B0218+357 (z = 0.944), PKS 1441+25 is the most distant very high energy (VHE) blazar detected to date. The observations were triggered by an outburst in 2015 April seen at GeV energies with the Large Area Telescope on board Fermi. Multi-wavelength observations suggest a subdivision of the high state into two distinct flux states. In the band covered by MAGIC, the variability time scale is estimated to be 6.4 +/- 1.9 days. Modeling the broadband spectral energy distribution with an external Compton model, the location of the emitting region is understood as originating in the jet outside the broad line region (BLR) during the period of high activity, while being partially within the BLR during the period of low (typical) activity. The observed VHE spectrum during the highest activity is used to probe the extragalactic background light at an unprecedented distance scale for ground-based gamma-ray astronomy., Comment: Corresponding Authors: J. Becerra (josefa.becerra@nasa.gov), M. Nievas Rosillo (mnievas@ucm.es), M. Manganaro (manganaro@iac.es), F. Tavecchio (fabrizio.tavecchio@brera.inaf.it) Published in The Astrophysical Journal Letters (ApJL), 2015ApJ...815L..23A, DOI: 10.1088/2041-8205/815/2/L23

Published
2015
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10. Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

Author

Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, and Croucher DR

Subjects
Animals, Antibodies, Monoclonal, Humanized pharmacology, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Cell Line, Tumor, Disease Models, Animal, Dose-Response Relationship, Drug, Female, Fluorescent Antibody Technique, Humans, Immunohistochemistry, Mice, Phosphorylation, Receptor, ErbB-2 antagonists & inhibitors, Signal Transduction drug effects, Trastuzumab pharmacology, Xenograft Model Antitumor Assays, Breast Neoplasms metabolism, Drug Resistance, Neoplasm, Protein Kinase Inhibitors pharmacology, Protein Multimerization, Receptor, ErbB-2 chemistry, Receptor, ErbB-2 metabolism
Abstract

Background: The oncogenic receptor tyrosine kinase (RTK) ERBB2 is known to dimerize with other EGFR family members, particularly ERBB3, through which it potently activates PI3K signalling. Antibody-mediated inhibition of this ERBB2/ERBB3/PI3K axis has been a cornerstone of treatment for ERBB2-amplified breast cancer patients for two decades. However, the lack of response and the rapid onset of relapse in many patients now question the assumption that the ERBB2/ERBB3 heterodimer is the sole relevant effector target of these therapies., Methods: Through a systematic protein-protein interaction screen, we have identified and validated alternative RTKs that interact with ERBB2. Using quantitative readouts of signalling pathway activation and cell proliferation, we have examined their influence upon the mechanism of trastuzumab- and pertuzumab-mediated inhibition of cell growth in ERBB2-amplified breast cancer cell lines and a patient-derived xenograft model., Results: We now demonstrate that inactivation of ERBB3/PI3K by these therapeutic antibodies is insufficient to inhibit the growth of ERBB2-amplified breast cancer cells. Instead, we show extensive promiscuity between ERBB2 and an array of RTKs from outside of the EGFR family. Paradoxically, pertuzumab also acts as an artificial ligand to promote ERBB2 activation and ERK signalling, through allosteric activation by a subset of these non-canonical RTKs. However, this unexpected activation mechanism also increases the sensitivity of the receptor network to the ERBB2 kinase inhibitor lapatinib, which in combination with pertuzumab, displays a synergistic effect in single-agent resistant cell lines and PDX models., Conclusions: The interaction of ERBB2 with a number of non-canonical RTKs activates a compensatory signalling response following treatment with pertuzumab, although a counter-intuitive combination of ERBB2 antibody therapy and a kinase inhibitor can overcome this innate therapeutic resistance.

Published
2019
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11. Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Author

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, and Lord CJ

Abstract

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Published
2018
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12. Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Author

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, and Lord CJ

Subjects
CRISPR-Cas Systems genetics, Cell Line, Tumor, Cell Nucleus drug effects, Cell Nucleus genetics, Cell Nucleus metabolism, DNA Damage drug effects, DNA Damage genetics, DNA Repair drug effects, DNA Repair genetics, Datasets as Topic, Drug Screening Assays, Antitumor methods, High-Throughput Screening Assays methods, Humans, Mutagenesis, Mutation, Osteosarcoma genetics, Poly(ADP-ribose) Polymerase Inhibitors pharmacology, Rad51 Recombinase metabolism, BRCA1 Protein genetics, BRCA2 Protein genetics, Drug Resistance, Neoplasm genetics, Osteosarcoma drug therapy, Poly(ADP-ribose) Polymerase Inhibitors therapeutic use
Abstract

Osteosarcoma (OS) is an aggressive sarcoma, where novel treatment approaches are required. Genomic studies suggest that a subset of OS, including OS tumour cell lines (TCLs), exhibit genomic loss of heterozygosity (LOH) patterns reminiscent of BRCA1 or BRCA2 mutant tumours. This raises the possibility that PARP inhibitors (PARPi), used to treat BRCA1/2 mutant cancers, could be used to target OS. Using high-throughput drug sensitivity screening we generated chemosensitivity profiles for 79 small molecule inhibitors, including three clinical PARPi. Drug screening was performed in 88 tumour cell lines, including 18 OS TCLs. This identified known sensitivity effects in OS TCLs, such as sensitivity to FGFR inhibitors. When compared to BRCA1/2 mutant TCLs, OS TCLs, with the exception of LM7, were PARPi resistant, including those with previously determined BRCAness LoH profiles. Post-screen validation experiments confirmed PARPi sensitivity in LM7 cells as well as a defect in the ability to form nuclear RAD51 foci in response to DNA damage. LM7 provides one OS model for the study of PARPi sensitivity through a potential defect in RAD51-mediated DNA repair. The drug sensitivity dataset we generated in 88 TCLs could also serve as a resource for the study of drug sensitivity effects in OS.

Published
2018
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13. Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.

Author

Fey D, Halasz M, Dreidax D, Kennedy SP, Hastings JF, Rauch N, Munoz AG, Pilkington R, Fischer M, Westermann F, Kolch W, Kholodenko BN, and Croucher DR

Subjects
Adolescent, Animals, Cell Line, Tumor, Child, Child, Preschool, Disease-Free Survival, Female, Follow-Up Studies, Humans, Infant, Male, N-Myc Proto-Oncogene Protein, Neoplasms, Experimental metabolism, Predictive Value of Tests, Survival Rate, Zebrafish metabolism, Zebrafish Proteins metabolism, Biomarkers, Tumor metabolism, MAP Kinase Kinase 4 metabolism, Models, Biological, Neuroblastoma metabolism, Neuroblastoma mortality, Nuclear Proteins metabolism, Oncogene Proteins metabolism, Signal Transduction
Abstract

Signaling pathways control cell fate decisions that ultimately determine the behavior of cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant information different from that contained in the static nature of other types of biomarkers. To investigate this hypothesis, we characterized the network that regulated stress signaling by the c-Jun N-terminal kinase (JNK) pathway in neuroblastoma cells. We generated an experimentally calibrated and validated computational model of this network and used the model to extract prognostic information from neuroblastoma patient-specific simulations of JNK activation. Switch-like JNK activation mediates cell death by apoptosis. An inability to initiate switch-like JNK activation in the simulations was significantly associated with poor overall survival for patients with neuroblastoma with or without MYCN amplification, indicating that patient-specific simulations of JNK activation could stratify patients. Furthermore, our analysis demonstrated that extracting information about a signaling pathway to develop a prognostically useful model requires understanding of not only components and disease-associated changes in the abundance or activity of the components but also how those changes affect pathway dynamics., (Copyright © 2015, American Association for the Advancement of Science.)

Published
2015
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14. Robustness and evolvability of the human signaling network.

Author

Kim J, Vandamme D, Kim JR, Munoz AG, Kolch W, and Cho KH

Subjects
Algorithms, Drug Discovery, Humans, Evolution, Molecular, Models, Biological, Signal Transduction genetics, Signal Transduction physiology
Abstract

Biological systems are known to be both robust and evolvable to internal and external perturbations, but what causes these apparently contradictory properties? We used Boolean network modeling and attractor landscape analysis to investigate the evolvability and robustness of the human signaling network. Our results show that the human signaling network can be divided into an evolvable core where perturbations change the attractor landscape in state space, and a robust neighbor where perturbations have no effect on the attractor landscape. Using chemical inhibition and overexpression of nodes, we validated that perturbations affect the evolvable core more strongly than the robust neighbor. We also found that the evolvable core has a distinct network structure, which is enriched in feedback loops, and features a higher degree of scale-freeness and longer path lengths connecting the nodes. In addition, the genes with high evolvability scores are associated with evolvability-related properties such as rapid evolvability, low species broadness, and immunity whereas the genes with high robustness scores are associated with robustness-related properties such as slow evolvability, high species broadness, and oncogenes. Intriguingly, US Food and Drug Administration-approved drug targets have high evolvability scores whereas experimental drug targets have high robustness scores.

Published
2014
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