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2. SELEX-discovered aptamer that inhibits cellular interleukin-17/interleukin-17 receptor interaction and antagonizes interleukin-17 signaling.

Author

Munshi, Arifur Rahman, Wang, Tong, Takamori, Yukio, Ando, Takehiro, Yokoyama, Takumi, Fuji, Daisuke, Xu, Zhehao, Vedi, Santhana, Yamamoto, Mizuki, Tsukamoto, Keita, and Kawakami, Takashi

Subjects
*APTAMERS, *INTERLEUKIN-17, *POLYMERASE chain reaction, *CELL communication
Abstract

This research is based on a Systematic Evolution of Ligands by EXponential enrichment, also referred to as in vitro selection against the extracellular domain of human interleukin-17 receptor A (IL-17RA). Pull-down assay via quantitative polymerase chain reaction and chemiluminescence detection showed that the cloned RNA with the enriched sequence bound to human IL-17RA and inhibited the interaction between IL-17RA and human interleukin-17A (IL-17A). We also revealed that the newly discovered IL-17RA-binding RNA aptamer bound to cellular IL-17RA, inhibited the cellular IL-17RA/IL-17A interaction, and antagonized cellular IL-17A signaling. [ABSTRACT FROM AUTHOR]

Published
2024
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