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1. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Oscar, Soldevila, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and del Toro, Maria Dolores

Published
2022
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4. Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study

Author

Cuperus, Nienke, Manfré, Giuseppe, Zamparini, Eleonora, Verhagen, Stéphanie, Horcajada, Juan P., Junyent, Joan Gómez, Alier, Albert, Soldevila, Laura, van Rijen, Miranda, Romme, Jannie, Ankert, Juliane, Whitehouse, Celia, Jones, Adrian, Cobo, Javier, Moreno, Javier, Meheut, Anne, Gledel, Claire, Perreau, Pauline, van Wensen, Remco J.A., Lindergard, Gabriella, Espindola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Rossi, Nicolò, Hendriks, Johannes G.E., Sorlí, Luisa, Murillo, Oscar, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and Del Toro, Maria Dolores

Published
2022
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5. Sociodemographic, clinical, and immunological factors associated with SARS-CoV-2 diagnosis and severe COVID-19 outcomes in people living with HIV: a retrospective cohort study

Author

Muntada, Esteve, Esteve, Anna, Riera, Melchor, Navarro, Gemma, Knobel, Hernando, Mallolas, Josep, Podzamczer, Daniel, Curran, Adrià, Burgos, Joaquín, Mateo, Maria Gracia, Gutierrez, Maria del Mar, Murillas, Javier, Homar, Francisco, Fernández-Montero, Jose Vicente, González, Eva, Peraire, Joaquim, Vidal, Francesc, Leon, Elena, Masabeu, Àngels, Orti, Amat-Joaquim, Dalmau, David, Jaen, Àngels, Deig, Elisabet, De Lazzari, Elisa, Berrocal, Leire, Fernandez, Guillem, Rodríguez, Lucía, Gargoulas, Freya, Vanrell, Toni, Rubia, Jose Carlos, Vilà, Josep, Martínez, Marina, Morell, Bibiana, Tamayo, Maribel, Palacio, Jorge, Ambrosioni, Juan, Laguno, Montse, Martínez-Rebollar, María, Blanco, José Luis, Garcia, Felipe, Martínez, Esteban, Torres, Berta, de la Mora, Lorena, Inciarte, Alexy, Ugarte, Ainoa, Chivite, Iván, González-Cordon, Ana, Leal, Lorna, Jou, Antoni, Saumoy, Maria, Silva, Ana, Scévola, Sofia, Navarro, Jordi, Suanzes, Paula, Mur, Isabel, Ribas, Maria Àngels, Campins, Antoni A, Fanjul, Francisco, Leyes, María, Peñaranda, María, Martin, María Luisa, Vilchez, Helem Haydee, Calzado, Sònia, Cervantes, Manel, Amengual, M. José, Navarro, Marta, Payeras, Antoni, Cifuentes, Carmen, Villoslada, Aroa, Sorní, Patrícia, Molero, Marta, Abdulghani, Nadia, Comella, Thaïs, Sola, Rocio, Vargas, Montserrat, Viladés, Consuleo, Martí, Anna, Barrufet, Pilar, Arbones, Laia, Chamarro, Elena, Cairó, Mireia, Martinez-Lacas, Xavier, Font, Roser, Macorigh, Lizza, Nomah, Daniel K, Reyes-Urueña, Juliana, Díaz, Yesika, Moreno, Sergio, Aceiton, Jordi, Bruguera, Andreu, Vivanco-Hidalgo, Rosa M, Llibre, Josep M, Domingo, Pere, Falcó, Vicenç, Imaz, Arkaitz, Cortés, Cristina, Force, Lluís, Letang, Emili, Vilaró, Ingrid, Casabona, Jordi, and Miro, Jose M

Published
2021
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7. Evolving trends in neuropsychological profiles of post COVID-19 condition: A 1-year follow-up in individuals with cognitive complaints.

Author

Grunden, Nicholas, Calabria, Marco, García-Sánchez, Carmen, Pons, Catalina, Arroyo, Juan Antonio, Gómez-Ansón, Beatriz, Estévez-García, Marina del Carmen, Belvís, Roberto, Morollón, Noemí, Cordero-Carcedo, Mónica, Mur, Isabel, Pomar, Virginia, and Domingo, Pere

Subjects
COGNITION, COGNITIVE testing, COGNITIVE analysis, COGNITIVE ability, COVID-19
Abstract

Cognitive difficulties are reported as lasting sequelae within post COVID-19 condition. However, the chronicity of these difficulties and related factors of fatigue, mood, and perceived health have yet to be fully determined. To address this, the current longitudinal study aimed to clarify the trends of cognitive test performance and cognitive domain impairment following COVID-19 onset, and whether hospitalization influences outcomes. 57 participants who reported subjective cognitive difficulties after confirmed COVID-19 infection were assessed at baseline (~6 months post COVID-19) and follow-up (~15 months later) visits. Assessments included measures across multiple cognitive domains and self-report questionnaires of fatigue, mood, and overall health. Analyses were conducted in three stages: at the test score level (raw and adjusted scores), at the cognitive domain level, and stratified by hospitalization status during infection. Results at the test-score level indicate that cognitive performance remains relatively stable across assessments at the group level, with no significant improvements in any adjusted test scores at follow-up. Cognitive domain analyses indicate significant reductions in attention and executive functioning impairment, while memory impairment is slower to resolve. On self-report measures, there was a significant improvement in overall health ratings at follow-up. Finally, those hospitalized during infection performed worse on timed cognitive measures across visits and accounted for a larger proportion of cases with short-term and working memory impairment at follow-up. Overall, our findings indicate that cognitive difficulties persist both at test score and cognitive domain levels in many cases of post COVID-19 condition, but evidence suggests some improvement in global measures of attention, executive functioning and overall self-rated health. Furthermore, an effect of hospitalization on cognitive symptoms post COVID-19 may be more discernible over time. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: a double-blind, placebo-controlled randomized clinical trial

Author

Grau-Pujol, Berta, Camprubí-Ferrer, Daniel, Marti-Soler, Helena, Fernández-Pardos, Marc, Carreras-Abad, Clara, Andrés, Maria Velasco-de, Ferrer, Elisabet, Muelas-Fernandez, Magdalena, Jullien, Sophie, Barilaro, Giuseppe, Ajanovic, Sara, Vera, Isabel, Moreno, Laura, Gonzalez-Redondo, Eva, Cortes-Serra, Núria, Roldán, Montserrat, Arcos, Ana Artes-de, Mur, Isabel, Domingo, Pere, Garcia, Felipe, Guinovart, Caterina, and Muñoz, Jose

Published
2021
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10. Incidence, associated disease burden and healthcare utilization due to Staphylococcus aureus prosthetic joint infection in European hospitals: the COMBACTE-NET ARTHR-IS multi-centre study

Author

Innovative Medicines Initiative, European Commission, GlaxoSmithKline, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), German Research Foundation, Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Soldevila-Boixader, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, Toro, María Dolores del, Innovative Medicines Initiative, European Commission, GlaxoSmithKline, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), German Research Foundation, Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Soldevila-Boixader, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and Toro, María Dolores del

Abstract

[Background] The aim of this study was to estimate the incidence, associated disease burden and healthcare utilization due to Staphylococcus aureus prosthetic joint infections (SA-PJI) after primary hip and knee arthroplasty in European centres., [Methods] This study was conducted in patients who underwent primary hip and knee arthroplasty in 19 European hospitals between 2014 and 2016. The global incidence of PJI and SA-PJI was calculated. The associated disease burden was measured indirectly as infection-related mortality plus loss of function. For healthcare utilization, number and duration of hospitalizations, number and type of surgical procedures, duration of antibiotic treatments, and number of outpatient visits were collected. Subgroup and regression analyses were used to evaluate the impact of SA-PJI on healthcare utilization, controlling for confounding variables., [Results] The incidence of PJI caused by any micro-organism was 1.41%, and 0.40% for SA-PJI. Among SA-PJI, 20.7% were due to MRSA with substantial regional differences, and were more frequent in partial hip arthroplasty (PHA). Related deaths and loss of function occurred in 7.0% and 10.2% of SA-PJI cases, respectively, and were higher in patients with PHA. Compared with patients without PJI, patients with SA-PJI had a mean of 1.4 more readmissions, 25.1 more days of hospitalization, underwent 1.8 more surgical procedures, and had 5.4 more outpatient visits, controlling for confounding variables. Healthcare utilization was higher in patients who failed surgical treatment of SA-PJI., [Conclusions] This study confirmed that the SA-PJI burden is high, especially in PHA, and provided a solid basis for planning interventions to prevent SA-PJI.

Published
2023

12. Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study

Author

Espindola, Reinaldo, primary, Vella, Venanzio, additional, Benito, Natividad, additional, Mur, Isabel, additional, Tedeschi, Sara, additional, Rossi, Nicolò, additional, Hendriks, Johannes G.E., additional, Sorlí, Luisa, additional, Murillo, Oscar, additional, Scarborough, Mathew, additional, Scarborough, Claire, additional, Kluytmans, Jan, additional, Ferrari, Mateo Carlo, additional, Pletz, Mathias W., additional, Mcnamara, Iain, additional, Escudero-Sanchez, Rosa, additional, Arvieux, Cedric, additional, Batailler, Cecile, additional, Dauchy, Frédéric-Antoine, additional, Liu, Wai-Yan, additional, Lora-Tamayo, Jaime, additional, Praena, Julia, additional, Ustianowski, Andrew, additional, Cinconze, Elisa, additional, Pellegrini, Michele, additional, Bagnoli, Fabio, additional, Rodríguez-Baño, Jesús, additional, Del Toro, Maria Dolores, additional, Cuperus, Nienke, additional, Manfré, Giuseppe, additional, Zamparini, Eleonora, additional, Verhagen, Stéphanie, additional, Horcajada, Juan P., additional, Junyent, Joan Gómez, additional, Alier, Albert, additional, Soldevila, Laura, additional, van Rijen, Miranda, additional, Romme, Jannie, additional, Ankert, Juliane, additional, Whitehouse, Celia, additional, Jones, Adrian, additional, Cobo, Javier, additional, Moreno, Javier, additional, Meheut, Anne, additional, Gledel, Claire, additional, Perreau, Pauline, additional, van Wensen, Remco J.A., additional, and Lindergard, Gabriella, additional

Published
2022
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13. Krebs von den Lungen-6 glycoprotein circulating levels are not useful as prognostic marker in COVID-19 pneumonia: A large prospective cohort study

Author

Castellví, Ivan, primary, Castillo, Diego, additional, Corominas, Hèctor, additional, Mariscal, Anaís, additional, Orozco, Sandra, additional, Benito, Natividad, additional, Pomar, Virginia, additional, Baucells, Andrés, additional, Mur, Isabel, additional, de la Rosa-Carrillo, David, additional, Lobo, David, additional, Millan, Ana Milena, additional, Hernández de Sosa, Nerea, additional, Filella, David, additional, Matas, Laia, additional, Martínez-Martínez, Laura, additional, Juarez, Cándido, additional, Casademont, Jordi, additional, and Domingo, Pere, additional

Published
2022
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14. Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy

Author

Domingo, Pere, Mateo, María Gracia, Villarroya, Joan, Cereijo, Rubén, Torres, Ferran, Campderrós, Laura, Gallego-Escuredo, José M., Gutierrez, María del Mar, Mur, Isabel, Corbacho, Noemí, Vidal, Francesc, Villarroya, Francesc, Giralt i Oms, Marta, Domingo, Pere, Mateo, María Gracia, Villarroya, Joan, Cereijo, Rubén, Torres, Ferran, Campderrós, Laura, Gallego-Escuredo, José M., Gutierrez, María del Mar, Mur, Isabel, Corbacho, Noemí, Vidal, Francesc, Villarroya, Francesc, and Giralt i Oms, Marta

Abstract

Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosclerosis and inflammation are related to growth differentiation factor-15 (GDF15). The relationship between metabolic disturbances, HALS, and CVR with GDF15 in PLWH is not known. Research design and methods: Circulating GDF15 levels in 152 PLWH (with HALS = 60, without HALS = 43, cART-naïve = 49) and 34 healthy controls were assessed in a cross-sectional study. Correlations with lipids, glucose homeostasis, fat distribution, and CVR were explored. Results: PLWH had increased circulating GDF15 levels relative to controls. The increase was the largest in cART-treated PLWH. Age, homeostatic model assessment of insulin resistance 1 (HOMA1-IR), HALS, dyslipidemia, C-reactive protein, and CVR estimated with the Framingham score correlated with GDF15 levels. The GDF15-Framingham correlation was lost after age adjustment. No correlation was found between GDF15 and the D:A:D Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:D) score estimated CVR. CVR independent predictors were patient group (naïve, HALS−, and HALS+) and cumulated protease inhibitor or nucleoside reverse transcriptase inhibitor exposure. Conclusions: PLWH, especially when cART-treated, has increased GDF15 levels-this increase is associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation-related parameters. GDF15 is unassociated with CVR when age-adjusted.

Published
2022

15. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Universidad de Sevilla. Departamento de Medicina, Consorcio COMBACTE-NET. Unión Europea, Consorcio COMBACTE-NET (GlaxoSmithKline Biologicals SA), Fondo Europeo de Desarrollo Regional “Una forma de alcanzar Europa”, Programa Operativo Crecimiento de la Inteligencia 2014-2020, Empresa Común para la Iniciativa sobre Medicamentos Innovadores, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Red Española de Investigación en Enfermedades Infecciosas, Plan Nacional de I + D + i 2013-2016, Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Rodríguez-Baño, Jesús, Toro López, María Dolores del, Lindergard, Gabriella, Universidad de Sevilla. Departamento de Medicina, Consorcio COMBACTE-NET. Unión Europea, Consorcio COMBACTE-NET (GlaxoSmithKline Biologicals SA), Fondo Europeo de Desarrollo Regional “Una forma de alcanzar Europa”, Programa Operativo Crecimiento de la Inteligencia 2014-2020, Empresa Común para la Iniciativa sobre Medicamentos Innovadores, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Red Española de Investigación en Enfermedades Infecciosas, Plan Nacional de I + D + i 2013-2016, Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Rodríguez-Baño, Jesús, Toro López, María Dolores del, and Lindergard, Gabriella

Abstract

Introduction Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess the incidence and risk factors for treatment failure (TF) of Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome. Methods A retrospective cohort study of SA-PJI was performed in 19 European hospitals between 2014 and 2016. The outcome variable was TF, including related mortality, clinical failure and functional loss both after the initial surgical procedure and after all procedures at 18 months. Predictors of TF were identified by logistic regression. Landmark analysis was used to avoid immortal time bias with rifampicin when debridement, antibiotics and implant retention (DAIR) was performed. Results One hundred twenty cases of SA-PJI were included. TF rates after the first and all surgical procedures performed were 32.8% and 24.2%, respectively. After all procedures, functional loss was 6.0% for DAIR and 17.2% for prosthesis removal. Variables independently associated with TF for the first procedure were Charlson ≥ 2, haemoglobin < 10 g/dL, bacteraemia, polymicrobial infection and additional debridement(s). For DAIR, TF was also associated with a body mass index (BMI) > 30 kg/m2 and delay of DAIR, while rifampicin use was protective. For all procedures, the variables associated with TF were haemoglobin < 10 g/dL, hip fracture and additional joint surgery not related to persistent infection. Conclusions TF remains common in SA-PJI. Functional loss accounted for a substantial proportion of treatment failures, particularly after prosthesis removal. Use of rifampicin after DAIR was associated with a protective effect. Among the risk factors identified, anaemia and obesity have not frequently been reported in previous studies.

Published
2022

16. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study-The ARTHR-IS Study Group [Dataset]

Author

Toro, María Dolores del [mdeltoro@us.es], Espíndola-Gómez, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Soldevila-Boixader, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, Toro, María Dolores del, Toro, María Dolores del [mdeltoro@us.es], Espíndola-Gómez, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Soldevila-Boixader, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and Toro, María Dolores del

Published
2022

17. Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study

Author

Espindola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Rossi, Nicolò, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, Toro, María Dolores del, ARTHR-IS group, Espindola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Rossi, Nicolò, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, Toro, María Dolores del, and ARTHR-IS group

Abstract

[Objectives] We aim to identify the preoperative and perioperative risk factors associated with post-surgical Staphylococcus aureus prosthetic joint infections (PJI) and to develop and validate risk-scoring systems, to allow a better identification of high-risk patients for more efficient targeted interventions., [Methods] We performed a multicenter matched case-control study of patients who underwent a primary hip and knee arthroplasty from 2014 to 2016. Two multivariable models by logistic regression were performed, one for the preoperative and one for perioperative variables; predictive scores also were developed and validated in an external cohort., [Results] In total, 130 cases and 386 controls were included. The variables independently associated with S. aureus-PJI in the preoperative period were (adjusted OR; 95% CI): body mass index >30 kg/m2 (3.0; 1.9 to 4.8), resident in a long-term care facility (2.8; 1.05 to 7.5), fracture as reason for arthroplasty (2.7; 1.4 to 5.03), skin disorders (2.5; 0.9 to 7.04), previous surgery in the index joint (2.4; 1.3 to 4.4), male sex (1.9; 1.2 to 2.9) and American Society of Anesthesiologists index score 3 to 4 (1.8; 1.2 to 2.9). The area under the receiver operating characteristic curve was 0.73 (95% CI 0.68 to 0.78). In perioperative model, the risk factors were the previous ones plus surgical antibiotic prophylaxis administered out of the first 60 minutes before incision (5.9; 2.1 to 16.2), wound drainage for >72 hours after arthroplasty (4.5; 1.9 to 19.4) and use of metal bearing material versus ceramic (1.9; 1.1 to 3.3). The area under the receiver operating characteristic curve was 0.78 (95% CI 0.72 to 0.83). The predictive scores developed were validated in the external cohort., [Discussion] Predictive scores for S. aureus-PJI were developed and validated; this information would be useful for implementation of specific preventive measures.

Published
2022

18. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study-The ARTHR-IS Study Group

Author

European Commission, GlaxoSmithKline, European Federation of Pharmaceutical Industries and Associations, Red Española de Investigación en Patología Infecciosa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Espíndola-Gómez, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Soldevila-Boixader, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, Toro, María Dolores del, European Commission, GlaxoSmithKline, European Federation of Pharmaceutical Industries and Associations, Red Española de Investigación en Patología Infecciosa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Espíndola-Gómez, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Óscar, Soldevila-Boixader, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Matteo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sánchez, Rosa, Arvieux, Cédric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and Toro, María Dolores del

Abstract

[Introduction] Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess the incidence and risk factors for treatment failure (TF) of Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome., [Methods] A retrospective cohort study of SA-PJI was performed in 19 European hospitals between 2014 and 2016. The outcome variable was TF, including related mortality, clinical failure and functional loss both after the initial surgical procedure and after all procedures at 18 months. Predictors of TF were identified by logistic regression. Landmark analysis was used to avoid immortal time bias with rifampicin when debridement, antibiotics and implant retention (DAIR) was performed., [Results] One hundred twenty cases of SA-PJI were included. TF rates after the first and all surgical procedures performed were 32.8% and 24.2%, respectively. After all procedures, functional loss was 6.0% for DAIR and 17.2% for prosthesis removal. Variables independently associated with TF for the first procedure were Charlson ≥ 2, haemoglobin < 10 g/dL, bacteraemia, polymicrobial infection and additional debridement(s). For DAIR, TF was also associated with a body mass index (BMI) > 30 kg/m2 and delay of DAIR, while rifampicin use was protective. For all procedures, the variables associated with TF were haemoglobin < 10 g/dL, hip fracture and additional joint surgery not related to persistent infection., [Conclusions] TF remains common in SA-PJI. Functional loss accounted for a substantial proportion of treatment failures, particularly after prosthesis removal. Use of rifampicin after DAIR was associated with a protective effect. Among the risk factors identified, anaemia and obesity have not frequently been reported in previous studies., [Trial registration] This study is registered at clinicaltrials.gov, registration no. NCT03826108.

Published
2022

19. Neuropsychological deficits in patients with cognitive complaints after COVID‐19

Author

García‐Sánchez, Carmen, primary, Calabria, Marco, additional, Grunden, Nicholas, additional, Pons, Catalina, additional, Arroyo, Juan Antonio, additional, Gómez‐Anson, Beatriz, additional, Lleó, Alberto, additional, Alcolea, Daniel, additional, Belvís, Roberto, additional, Morollón, Noemí, additional, Mur, Isabel, additional, Pomar, Virginia, additional, and Domingo, Pere, additional

Published
2022
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20. Increased Circulating Levels of Growth Differentiation Factor 15 in Association with Metabolic Disorders in People Living with HIV Receiving Combined Antiretroviral Therapy

Author

Domingo, Pere, primary, Mateo, María Gracia, additional, Villarroya, Joan, additional, Cereijo, Rubén, additional, Torres, Ferran, additional, Domingo, Joan C., additional, Campderrós, Laura, additional, Gallego-Escuredo, José M., additional, Gutierrez, María del Mar, additional, Mur, Isabel, additional, Corbacho, Noemí, additional, Vidal, Francesc, additional, Villarroya, Francesc, additional, and Giralt, Marta, additional

Published
2022
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21. Sociodemographic, clinical, and immunological factors associated with SARS-CoV-2 diagnosis and severe COVID-19 outcomes in people living with HIV: a retrospective cohort study

Author

Nomah, Daniel K, primary, Reyes-Urueña, Juliana, additional, Díaz, Yesika, additional, Moreno, Sergio, additional, Aceiton, Jordi, additional, Bruguera, Andreu, additional, Vivanco-Hidalgo, Rosa M, additional, Llibre, Josep M, additional, Domingo, Pere, additional, Falcó, Vicenç, additional, Imaz, Arkaitz, additional, Cortés, Cristina, additional, Force, Lluís, additional, Letang, Emili, additional, Vilaró, Ingrid, additional, Casabona, Jordi, additional, Miro, Jose M, additional, Muntada, Esteve, additional, Esteve, Anna, additional, Riera, Melchor, additional, Navarro, Gemma, additional, Knobel, Hernando, additional, Mallolas, Josep, additional, Podzamczer, Daniel, additional, Curran, Adrià, additional, Burgos, Joaquín, additional, Mateo, Maria Gracia, additional, Gutierrez, Maria del Mar, additional, Murillas, Javier, additional, Homar, Francisco, additional, Fernández-Montero, Jose Vicente, additional, González, Eva, additional, Peraire, Joaquim, additional, Vidal, Francesc, additional, Leon, Elena, additional, Masabeu, Àngels, additional, Orti, Amat-Joaquim, additional, Dalmau, David, additional, Jaen, Àngels, additional, Deig, Elisabet, additional, De Lazzari, Elisa, additional, Berrocal, Leire, additional, Fernandez, Guillem, additional, Rodríguez, Lucía, additional, Gargoulas, Freya, additional, Vanrell, Toni, additional, Rubia, Jose Carlos, additional, Vilà, Josep, additional, Martínez, Marina, additional, Morell, Bibiana, additional, Tamayo, Maribel, additional, Palacio, Jorge, additional, Ambrosioni, Juan, additional, Laguno, Montse, additional, Martínez-Rebollar, María, additional, Blanco, José Luis, additional, Garcia, Felipe, additional, Martínez, Esteban, additional, Torres, Berta, additional, de la Mora, Lorena, additional, Inciarte, Alexy, additional, Ugarte, Ainoa, additional, Chivite, Iván, additional, González-Cordon, Ana, additional, Leal, Lorna, additional, Jou, Antoni, additional, Saumoy, Maria, additional, Silva, Ana, additional, Scévola, Sofia, additional, Navarro, Jordi, additional, Suanzes, Paula, additional, Mur, Isabel, additional, Ribas, Maria Àngels, additional, Campins, Antoni A, additional, Fanjul, Francisco, additional, Leyes, María, additional, Peñaranda, María, additional, Martin, María Luisa, additional, Vilchez, Helem Haydee, additional, Calzado, Sònia, additional, Cervantes, Manel, additional, Amengual, M. José, additional, Navarro, Marta, additional, Payeras, Antoni, additional, Cifuentes, Carmen, additional, Villoslada, Aroa, additional, Sorní, Patrícia, additional, Molero, Marta, additional, Abdulghani, Nadia, additional, Comella, Thaïs, additional, Sola, Rocio, additional, Vargas, Montserrat, additional, Viladés, Consuleo, additional, Martí, Anna, additional, Barrufet, Pilar, additional, Arbones, Laia, additional, Chamarro, Elena, additional, Cairó, Mireia, additional, Martinez-Lacas, Xavier, additional, Font, Roser, additional, and Macorigh, Lizza, additional

Published
2021
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22. Community-based entomological surveillance in three Chagas disease-endemic regions in sub-Andean Bolivia

Author

Rojas-Cortez, Mirko, primary, Pinazo, Maria-Jesus, additional, Gascon, Joaquim, additional, Gamarra, Enzo, additional, Grageda, Rosse Mary, additional, Fernandez, Rene, additional, Rueda, Eduardo, additional, Pinto, Jimy, additional, Anzoleaga, Helmut Magne, additional, Caballero, Yurly Escobar, additional, Urioste, Gloria Sandy, additional, Sanchez, Jareth, additional, Saravia, Ruth, additional, Castellon, Mario, additional, Garcia, Wilson, additional, Daza, Lourdes Ortiz, additional, Mur, Isabel Gonzales, additional, Lozano, Daniel, additional, Carvalho-Costa, Filipe Anibal, additional, Monteiro, Fernando Araújo, additional, and Torrico, Faustino, additional

Published
2021
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24. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis

Author

The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, [missing], Domingo, Pere, Mur, Isabel, Mateo, Gracia María, Gutierrez, Maria del Mar, Pomar, Virginia, de Benito, Natividad, Corbacho, Noemí, Herrera, Silvia, Millan, Lucia, Muñoz, Jessica, Malouf, Jorge, Molas, Maria Ema, Asensi, Victor, Horcajada, Juan Pablo, Estrada, Vicente, Gutierrez, Felix, Torres, Ferran, Perez-Molina, Jose A, Fortun, Jesús, Villar, Luisa M, Hohenthal, Ulla, Marttila, Harri, Vuorinen, Tytti, Nordberg, Marika, Valtonen, Mika, Frigault, Matthew J, Mansour, Michael K, Patel, Naomi J, Fernandes, Ana, Harvey, Liam, Foulkes, Andrea S, Healy, Brian C, Shah, Ruta, Bensaci, Ana Maria, Woolley, Ann E., Nikiforow, Sarah, Lin, Nina, Sagar, Manish, Shrager, Harry, Huckins, David S., Axelrod, Matthew, Pincus, Michael D, Fleisher, Jorge, Lampa, Jon, Nowak, Piotr, Vesterbacka, Jan C., Rasmuson, Johan, Skorup, Paul, Janols, Helena, Niward, Katarina F, Chatzidionysiou, Katerina, Asgeirsson, Hilmir, Parke, Åsa, Blennow, Ola, Svensson, Anna-Karin, Aleman, Soo, Sönnerborg, Anders, Henter, Jan-Inge, Horne, Anna Carin, Al-Beidh, Farah, Angus, Derek, Annane, Djillali, Arabi, Yaseen, Beane, Abigail, Berry, Scott, Bhimani, Zahra, Bonten, Marc, Bradbury, Charlotte, Brunkhorst, Frank, Buxton, Meredith, Cheng, Allen, Cove, Matt, De Jong, Menno, Derde, Lennie, Estcourt, Lise, Goossens, Herman, Gordon, Anthony, Green, Cameron, Haniffa, Rashan, Ichihara, Nao, Lamontagne, Francois, Lawler, Patrick, Litton, Ed, Marshall, John, McArthur, Colin, McAuley, Daniel, McGuinness, Shay, McVerry, Bryan, Montgommery, Stephanie, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane, Reyes, Felipe, Rowan, Kathryn, Saito, Hiroki, Santos, Marlene, Seymour, Chris, Shankar-Hari, Manu, Turgeon, Alexis, Turner, Anne, van Bentum-Puijk, Wilma, van de Veerdonk, Frank, Webb, Steve, Zarychanski, Ryan, Baillie, J Kenneth, Beasley, Richard, Cooper, Nichola, Fowler, Robert, Galea, James, Hills, Thomas, King, Andrew, Morpeth, Susan, Netea, Mihai, Ogungbenro, Kayode, Pettila, Ville, Tong, Steve, Uyeki, Tim, Youngstein, Taryn, Higgins, Alisa, Lorenzi, Elizabeth, Berry, Lindsay, Salama, Carlos, Rosas, Ivan O., Ruiz-Antorán, Belén, Muñez Rubio, Elena, Ramos Martínez, Antonio, Campos Esteban, José, Avendaño Solá, Cristina, Pizov, Reuven, Sanz Sanz, Jesus, Abad-Santos, Francisco, Bautista-Hernández, Azucena, García-Fraile, Lucio, Barrios, Ana, Gutiérrez Liarte, Ángela, Alonso Pérez, Tamara, Rodríguez-García, Sebastian C, Mejía-Abril, Gina, Prieto, Jose Carlos, Leon, Rafael, VEIGA, VIVIANE C., SCHEINBERG, PHILLIP, FARIAS, DANIELLE L.C., PRATS, JOÃO G., CAVALCANTI, ALEXANDRE B., MACHADO, FLAVIA R., ROSA, REGIS G., BERWANGER, OTÁVIO, AZEVEDO, LUCIANO C.P., LOPES, RENATO D., DOURADO, LETICIA K., CASTRO, CLAUDIO G., ZAMPIERI, FERNANDO G., AVEZUM, ALVARO, LISBOA, THIAGO C., ROJAS, SALOMÓN S.O., COELHO, JULIANA C., LEITE, RODRIGO T., CARVALHO, JULIO CESAR, ANDRADE, LUIS E.C., SANDES, ALEX R., PINTÃO, MARIA CAROLINA T., SANTOS, SUELI V., ALMEIDA, THIAGO M.L., COSTA, ANDRÉ N., GEBARA, OTAVIO C.E., FREITAS, FLAVIO G.R., PACHECO, EDUARDO S., MACHADO, DAVID J.B., MARTIN, JOSIANE, CONCEIÇÃO, FABIO G., SIQUEIRA, SUELLEN R.R., DAMIANI, LUCAS P., ISHIHARA, LUCIANA M., SCHNEIDER, DANIEL, DE SOUZA, DENISE, Hermine, Olivier, Mariette, Xavier, Tharaux, Pierre Louis, Resche Rigon, Matthieu, Porcher, Raphael, Ravaud, Philippe, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Tibi, Annick, Yazdanpanah, Yazdan, Dougados, Maxime, Bureau, Serge, Horby, Peter W, Landray, Martin J, Baillie, Kenneth J, Buch, Maya H, Chappell, Lucy C, Day, Jeremy N, Faust, Saul N, Haynes, Richard, Jaki, Thomas, Jeffery, Katie, Juszczak, Edmund, Lim, Wei Shen, Mafham, Marion, Montgomery, Alan, Mumford, Andrew, Thwaites, Guy, Kamarulzaman, Adeeba, Syed Omar, Sharifah Faridah, Ponnampalavanar, Sasheela, Raja Azwa, Raja Iskandar Syah, Wong, Pui Li, Kukreja, Anjanna, Ong, Hang Cheng, Sulaiman, Helmi, Basri, Sazali, Ng, Rong Xiang, Megat Johari, Bushra, Rajasuriar, Reena, Chong, Meng Li, Neelamegam, Malinee, Syed Mansor, Syed Mukhtar, Zulhaimi, Nurul Syuhada, Lee, Cheng Siang, Altice, Frederick, Price, Christina, Malinis, Maricar, Hasan, Mohd Shahnaz, Wong, Chee Kuan, Chidambaram, Suresh, Misnan, Nor Arisah, Mohd Thabit, Alif Adlan, Sim, Benedict, Bidin, Farah Nadiah, Mohd Abd Rahim, Mohd Abd Hafiz, Saravanamuttu, Sujana, Tuang, Wei Xuan, Mohamed Gani, Yasmin, Thangavelu, Suvintheran, Tay, Kim Heng, Ibrahim, Nur Munirah, Halid, Luqman Alhakim, Tan, Kok Tong, Mukri, Mohd Noor Azreet, Arip, Masita, Koh, Hui Moon, Syed Badaruddin, Syarifah Nurul Ain, Raja Sureja, Letchumi, Chun, Geok Ying, TORRE-CISNEROS, JULIAN, MERCHANTE, NICOLAS, LEON, RAFAEL, CARCEL, SHEILA, GARRIDO, JOSE CARLOS, Galun, Eitan, Soriano, Alex, Martínez, José Antonio, Castán, Clara, Paredes, Roger, Dalmau, David, Carbonell, Cristina, Espinosa, Gerard, Castro, Pedro, Muñóz, José, Almuedo, Alex, Prieto, Sergio, Pacheco, Iván, Ratain, Mark, Pisano, Jennifer, Strek, Mary, Adegunsoye, Ayodeji, Karrison, Theodore, Declercq, Jozefien, Van Damme, Karel, De Leeuw, Elisabeth, Bosteels, Cedric, Maes, Bastiaan, Vale, Claire L., Godolphin, Peter J., Fisher, David, Higgins, Julian P. T., Spiga, Francesca, Savovic, Jelena, Tierney, Jayne, Baron, Gabriel, Benbenishty, Julie S., Berry, Lindsay R., Broman, Niklas, Cavalcanti, Alexandre Biasi, Colman, Roos, De Buyser, Stefanie, Derde, Lennie P. G., Omar, Sharifah Faridah, Fernandez-Cruz, Ana, Feuth, Thijs, Garcia, Felipe, Garcia-Vicuna, Rosario, Gonzalez-Alvaro, Isidoro, Gordon, Anthony C., Horby, Peter W., Horick, Nora K., Kumar, Kuldeep, Lambrecht, Bart, Landray, Martin J., Leal, Lorna, Lederer, David J., Merchante, Nicolas, Mohan, Shalini V., Nivens, Michael C., Oksi, Jarmo, Perez-Molina, Jose A., Postma, Simone, Ramanan, Athimalaipet V., Reid, Pankti D., Rutgers, Abraham, Sancho-Lopez, Aranzazu, Seto, Todd B., Sivapalasingam, Sumathi, Soin, Arvinder Singh, Staplin, Natalie, Stone, John H., Strohbehn, Garth W., Sunden-Cullberg, Jonas, Torre-Cisneros, Julian, Tsai, Larry W., van Hoogstraten, Hubert, van Meerten, Tom, Veiga, Viviane Cordeiro, Westerweel, Peter E., Diaz, Janet V., Marshall, John C., Sterne, Jonathan A. C., Translational Immunology Groningen (TRIGR), Stem Cell Aging Leukemia and Lymphoma (SALL), World Health Organization, and Group, WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working

Subjects
Male, medicine.medical_specialty, Randomization, Secondary infection, Placebo, Antibodies, Monoclonal, Humanized, Internal medicine, Cause of Death, Medicine and Health Sciences, Medicine, Humans, Prospective Studies, Prospective cohort study, Glucocorticoids, METAANALYSIS, Cause of death, Aged, Randomized Controlled Trials as Topic, business.industry, Coinfection, Interleukin-6, COVID-19, Odds ratio, General Medicine, Middle Aged, Respiration, Artificial, COVID-19 Drug Treatment, Clinical trial, Hospitalization, Meta-analysis, Disease Progression, Drug Therapy, Combination, Female, business
Abstract

[Importance] Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm., [Objective] To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes., [Data Sources] Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts., [Study Selection] Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria., [Data Extraction and Synthesis] In this prospective meta-analysis, risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance–weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality., [Main Outcomes and Measures] The primary outcome measure was all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days., [Results] A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P = .003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P, [Conclusions and Relevance] In this prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality., [Trial Registration] PROSPERO Identifier: CRD42021230155., Funding for administrative and communications support was provided by the World Health Organization.

Published
2021

25. Additional file 1 of Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: a double-blind, placebo-controlled randomized clinical trial

Author

Grau-Pujol, Berta, Camprub��-Ferrer, Daniel, Marti-Soler, Helena, Fern��ndez-Pardos, Marc, Carreras-Abad, Clara, Andr��s, Maria Velasco-de, Ferrer, Elisabet, Muelas-Fernandez, Magdalena, Jullien, Sophie, Barilaro, Giuseppe, Ajanovic, Sara, Vera, Isabel, Moreno, Laura, Gonzalez-Redondo, Eva, Cortes-Serra, N��ria, Rold��n, Montserrat, Arcos, Ana Artes-de, Mur, Isabel, Domingo, Pere, Garcia, Felipe, Guinovart, Caterina, and Mu��oz, Jose

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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26. Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement

Author

Rivera, Alba, Sánchez, Alba, Luque Pardos, Sònia, Mur, Isabel, Puig, Lluís, Crusi, Xavier, González, José Carlos, Sorli Redó, M. Luisa, González, Aránzazu, Horcajada Gallego, Juan Pablo, Navarro, Ferran, and Benito, Natividad

Subjects
musculoskeletal diseases, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Prosthetic joint infection, medicine.medical_treatment, 030106 microbiology, Cefazolin, Antibiotic levels, knee arthroplasty, surgical antimicrobial prophylaxis, Biochemistry, Microbiology, Prosthetic joint infection prevention, Article, Intraoperative cultures, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Hip replacement, Serum bactericidal titer, medicine, Surgical antimicrobial prophylaxis, surgical site infection prevention, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, prosthetic joint infection, hip arthroplasty, 030222 orthopedics, intraoperative cultures, prosthetic joint infection prevention, business.industry, lcsh:RM1-950, Surgical wound, antibiotic levels, Antimicrobial, Arthroplasty, Knee arthroplasty, Surgical site infection prevention, Infectious Diseases, lcsh:Therapeutics. Pharmacology, Vancomycin, Hip arthroplasty, Gentamicin, serum bactericidal titer, business, Cefuroxime, medicine.drug
Abstract

Surgical antimicrobial prophylaxis (SAP) is important for the prevention of prosthetic joint infections (PJIs) and must be effective against the microorganisms most likely to contaminate the surgical site. Our aim was to compare different SAP regimens (cefazolin, cefuroxime, or vancomycin, alone or combined with gentamicin) in patients undergoing total knee (TKA) and hip (THA) arthroplasty. In this preclinical exploratory analysis, we analyzed the results of intraoperative sample cultures, the ratio of plasma antibiotic levels to the minimum inhibitory concentrations (MICs) for bacteria isolated at the surgical wound and ATCC strains, and serum bactericidal titers (SBT) against the same microorganisms. A total of 132 surgical procedures (68 TKA, 64 THA) in 128 patients were included. Cultures were positive in 57 (43.2%) procedures (mostly for coagulase-negative staphylococci and Cutibacterium spp.), the rate was lower in the group of patients receiving combination SAP (adjusted OR 0.475, CI95% 0.229&ndash, 0.987). The SAP regimens evaluated achieved plasma levels above the MICs in almost all of intraoperative isolates (93/94, 98.9%) and showed bactericidal activity against all of them (SBT range 1:8&ndash, 1:1024), although SBTs were higher in patients receiving cefazolin and gentamicin-containing regimens. The potential clinical relevance of these findings in the prevention of PJIs remains to be determined.

Published
2021

27. Pharmacological considerations for the treatment of COVID-19 in people living with HIV (PLWH)

Author

Universitat Rovira i Virgili, Gutierrez, Maria Del Mar; Mur, Isabel; Mateo, Maria Gracia; Vidal, Francesc; Domingo, Pere, Universitat Rovira i Virgili, and Gutierrez, Maria Del Mar; Mur, Isabel; Mateo, Maria Gracia; Vidal, Francesc; Domingo, Pere

Abstract

Introduction When coronavirus infectious disease-2019 (COVID-19) blew up, ill-fated auguries on the collision between COVID-19 and the human immunodeficiency virus (HIV) epidemics loomed. Areas covered Data from observational studies suggest similar incidence attacks of SARS-CoV-2 infection in people living with HIV (PLWH) and HIV-uninfected populations. The mortality rate of COVID-19 is similar in both populations too. The authors discuss the role of combination antiretroviral therapy (cART) in preventing infection or reducing COVID-19 severity. They also discuss the pharmacological interventions for COVID-19 in PLWH. Expert opinion Management of COVID-19 in PLWH is no different from the general population. It should be based on careful supportive care, emphasizing lung-protective ventilation, and wise pharmacological interventions. The antiviral drug remdesivir and dexamethasone are the only pharmacological interventions with clinical benefit for COVID-19, whereas anticoagulation may prevent thrombotic complications. The experience with using these drugs in PLWH is limited, which prevents from rendering well-founded conclusions. Until more data on COVID-19 in PLWH become available, the best weapons within our reach are sound supportive care and sensible use of RDV and dexamethasone, bearing in mind the potential for drug-drug interactions of most corticosteroids and antiretroviral drugs.

Published
2021

28. Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: initial results of a double-blind, placebo-controlled randomized clinical trial

Author

Grau-Pujol, Berta, primary, Camprubí, Daniel, additional, Marti-Soler, Helena, additional, Fernández-Pardos, Marc, additional, Carreras-Abad, Clara, additional, Andrés, Maria Velasco de, additional, Ferrer, Elisabet, additional, Muelas-Fernandez, Magdalena, additional, Jullien, Sophie, additional, Barilaro, Giuseppe, additional, Ajanovic, Sara, additional, Vera, Isabel, additional, Moreno, Laura, additional, Gonzalez-Redondo, Eva, additional, Cortes-Serra, Núria, additional, Roldán, Montserrat, additional, Arcos, Ana Artes de, additional, Mur, Isabel, additional, Domingo, Pere, additional, Garcia, Felipe, additional, Guinovart, Caterina, additional, and Muñoz, Jose, additional

Published
2021
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29. Do prosthetic joint infections cured at the first treatment attempt worsen the functional outcome of patients with joint replacements? A retrospective matched cohort study

Author

Mur, Isabel, Jordán, Marcos, Rivera, Alba, Pomar, Virginia, González, José Carlos, López-Contreras, Joaquín, Crusi, Xavier, Navarro Risueño, Ferran, Gurguí Ferrer, Mercè., and Benito, Natividad

Subjects
musculoskeletal diseases, Prosthetic joint infection, Arthroplasty infection, Prosthetic joint infection functional outcome, Prosthetic joint infection ambulatory outcome
Abstract

Objectives: To assess the effect on the functional ambulatory outcome of postoperative joint infection (PJI) cured at the first treatment attempt versus not developing PJI in patients with hip and knee prostheses. Methods: In a single-hospital retrospectively matched cohort study, each patient with PJI between 2007 and 2016 was matched on age, sex, type of prosthesis and year of implantation with two other patients with uninfected arthroplasties. The definition of a PJI cure included infection eradication, no further surgical procedures, no PJI-related mortality and no suppressive antibiotics. Functional ambulatory status evaluated one year after the last surgery was classified into four simple categories: able to walk without assistance, able to walk with one crutch, able to walk with two crutches, and unable to walk. Patients with total hip arthroplasties (THAs), total knee arthroplasties (TKAs) and partial hip arthroplasties (PHAs) were analysed separately. Results: A total of 109 PJI patients (38 TKA, 41 THA, 30 PHA) and 218 non-PJI patients were included. In a model adjusted for clinically relevant variables, PJI was associated with a higher risk of needing an assistive device for ambulation (vs. walking without aid) among THA (adjusted odds ratio (OR) 3.10, 95% confidence interval (95% CI) 1.26-7.57; p = 0.014) and TKA patients (OR 5.40, 95% CI 2.12-13.67; p < 0.001), and with requiring two crutches to walk or being unable to walk (vs. walking unaided or with one crutch) among PHA patients (OR 3.05, 95% CI 1.01-9.20; p = 0.047). Conclusions: Ambulatory outcome in patients with hip and knee prostheses with postoperative PJI is worse than in patients who do not have PJI.

Published
2020

32. Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement

Author

Rivera, Alba, primary, Sánchez, Alba, additional, Luque, Sonia, additional, Mur, Isabel, additional, Puig, Lluís, additional, Crusi, Xavier, additional, González, José Carlos, additional, Sorlí, Luisa, additional, González, Aránzazu, additional, Horcajada, Juan Pablo, additional, Navarro, Ferran, additional, and Benito, Natividad, additional

Published
2020
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33. Do Prosthetic Joint Infections Worsen the Functional Ambulatory Outcome of Patients with Joint Replacements? A Retrospective Matched Cohort Study

Author

Mur, Isabel, primary, Jordán, Marcos, additional, Rivera, Alba, additional, Pomar, Virginia, additional, González, José Carlos, additional, López-Contreras, Joaquín, additional, Crusi, Xavier, additional, Navarro, Ferran, additional, Gurguí, Mercè, additional, and Benito, Natividad, additional

Published
2020
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34. Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: initial results of a double-blind, placebo-controlled randomized clinical trial

Author

Grau-Pujol, Berta, primary, Camprubí, Daniel, additional, Marti-Soler, Helena, additional, Fernández-Pardos, Marc, additional, Carreras-Abad, Clara, additional, Andrés, Maria Velasco de, additional, Ferrer, Elisabet, additional, Muelas-Fernandez, Magdalena, additional, Jullien, Sophie, additional, Barilaro, Giuseppe, additional, Ajanovic, Sara, additional, Vera, Isabel, additional, Moreno, Laura, additional, Gonzalez-Redondo, Eva, additional, Cortes-Serra, Núria, additional, Roldán, Montserrat, additional, Arcos, Ana Artes de, additional, Mur, Isabel, additional, Domingo, Pere, additional, Garcia, Felipe, additional, Guinovart, Caterina, additional, and Muñoz, Jose, additional

Published
2020
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35. Timing of implant-removal in late acute periprosthetic joint infection: A multicenter observational study

Author

Wouthuyzen-Bakker, Marjan, Sebillotte, Marine, Lomas, Jose, Kendrick, Benjamin, Benavent Palomares, Eva, Murillo, Oscar, Parvizi, Javad, Shohat, Noam, Cobo Reinoso, Javier, Escudero Sanchez, Rosa, Fernandez-Sampedro, Marta, Senneville, Eric, Huotari, Kaisa, Barbero Allende, Jose Maria, Blanco Garcia, Antonio, Lora-Tamayo, Jaime, Ferrari, Matteo Carlo, Vaznaisiene, Danguole, Yusuf, Erlangga, Aboltins, Craig, Trebse, Rihard, Salles, Mauro Jose, Benito, Natividad, Vila, Andrea, Dolores Del Toro, Maria, Kramer, Tobias Siegfried, Petersdorf, Sabine, Diaz-Brito, Vicens, Tufan, Zeliha Kocak, Sanchez, Marisa, Arvieux, Cedric, Soriano, Alex, Gougeon, Anne, Common, Harold, Meheut, Anne, Gomez-Junyent, Joan, Tarabichi, Majd, Demirturk, Aybegum, Ribeiro, Taiana, Honda, Emerson, Polesello, Giancarlo, Jutte, Paul, Ploegmakers, Joris, Lowik, Claudia, Bori, Guillem, Morata, Laura, Lozano, Luis, Mancheno, Mikel, Chaves, Fernando, Smolders, David, Inthavong, Phongsakone, Taylor, Adrian, Digumber, Marc, Pfang, Bernadette Genevieve, Tornero, Eduard, Moreno, Encarna, Noth, Ulrich, Rivero, Cynthia, Coll, Pere, Crusi, Xavier, Mur, Isabel, Dapas, Juan, Tattevin, Pierre, Esteban, Jaime, Garcia-Canete, Joaquin, Scarborough, Matthew, Man, Biomaterials and Microbes (MBM), Public Health Research (PHR), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), ESCMID Study Grp Implant-Associate, University of Helsinki, Department of Medicine, Clinicum, Infektiosairauksien yksikkö, and HUS Inflammation Center

Subjects
Male, 0301 basic medicine, medicine.medical_treatment, Failure, Periprosthetic, Revision surgery, Periprosthetic joint infection, TOTAL HIP-ARTHROPLASTY, Severity of Illness Index, Prosthesis, TOTAL KNEE ARTHROPLASTY, 0302 clinical medicine, 030212 general & internal medicine, FAILED IRRIGATION, FUNCTIONAL OUTCOMES, Late acute, Aged, 80 and over, Debridement, Disease Management, Hematogenous, Prostheses and Implants, Treatment Outcome, Infectious Diseases, Female, Algorithms, Microbiology (medical), medicine.medical_specialty, Prosthesis-Related Infections, 030106 microbiology, Implant removal, 03 medical and health sciences, medicine, MANAGEMENT, Humans, In patient, Propensity Score, Device Removal, Aged, Retrospective Studies, Arthritis, Infectious, business.industry, Survival Analysis, Surgery, Multicenter study, 3121 General medicine, internal medicine and other clinical medicine, Observational study, Implant, Human medicine, business, Biomarkers
Abstract

Objectives: We evaluated the treatment outcome in late acute (LA) periprosthetic joint infections (PJI) treated with debridement and implant retention (DAIR) versus implant removal. Methods: In a large multicenter study, LA PJIs of the hip and knee were retrospectively evaluated. Failure was defined as: PJI related death, prosthesis removal or the need for suppressive antibiotic therapy. LA PJI was defined as acute symptoms = 3 (OR 2.9), PJI caused by S. aureus (OR 1.8) and implant retention (OR 3.1) were independent predictors for failure in the multivariate analysis. Conclusion: DAIR is a viable surgical treatment for most patients with LA PJI, but implant removal should be considered in a subset of patients, especially in those with a CRIME80-score >= 3. (C) 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Published
2019

36. The Different Microbial Etiology of Prosthetic Joint Infections According to Route of Acquisition and Time After Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms

Author

Benito, Natividad, Mur, Isabel, Ribera, Alba, Soriano, Alex, Rodriguez-Pardo, Dolors, Sorli, Luisa, Cobo, Javier, Fernandez-Sampedro, Marta, Dolores del Toro, Maria, Guio, Laura, Praena, Julia, Bahamonde, Alberto, Riera, Melchor, Esteban, Jaime, Mirena Baraia-Etxaburu, Josu, Martinez-Alvarez, Jesus, Jover-Saenz, Alfredo, Duenas, Carlos, Ramos, Antonio, Sobrino, Beatriz, Euba, Gorane, Morata, Laura, Pigrau, Carles, Horcajada, Juan P., Coll, Pere, Crusi, Xavier, Ariza, Javier, Garcia-Gonzalez, Merce, Perez-Villar, Ferran, Prats-Gispert, Laura, Ramirez-Hidalgo, Maria, De-la-Pena-Trigueros, Mireia, Lopez-Azkarreta, Inigo, Lopez-Martinez, Miriam, Lora-Tamayo, Jaime, Murillo, Oscar, Pedrero, Salvador, Amador, Juan, Garcia-Paino, Luis, Parrondo, Susana, Raya, Carmen, Moreno, Alfonso, Aranzazu Blanco-Martinez-de-Morentin, Maria, Genoveva Zapico-Aldea, Laura Rodriguez-Fernandez, Lozano, Luis, Munoz-Mahamud, Ernesto, Merino-Perez, Josu, Alier, Albert, Prim, Nuria, Puig, Luis, Aunon, Alvaro, Blanco, Antonio, Garcia-Canete, Joaquin, Parron-Cambero, Raul, Carmen Farinas, M., Manuel-Bloque, Ricardo, Salas-Venero, Carlos, Campo-Loarte, Jesus, Munez-Rubio, Elena, Sanchez-Romero, Isabel, Escudero-Sanchez, Rosa, Ruiz-Carbajosa, Patricia, Gonzalez, Aranzazu, Carlos Gonzalez, Jose, Jordan, Marcos, Rivera, Alba, Marinescu, Carmen, Montaner, Francisco, Ramirez, Antonio, Corona, Pablo S., Lung, Maily, Puig-Asensio, Mireia, Angel Muniain-Ezcurra, Miguel, Penas-Espinar, Cecilia, Isabel Suarez, Ana, Jose Gomez, Maria, Lopez-Pliego, Macarena, REIPI Spanish Network Res Infect D, SEIMC Spanish Soc Infect Dis Clini, Universidad de Cantabria, Institut Català de la Salut, [Benito N, Mur I] Unitat de Malalties Infeccioses, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. [Ribera A] Departament de Malalties Infeccioses, Hospital Universitari Bellvitge, Barcelona, Spain. [Soriano A] Departament de Malalties Infeccioses, Hospital Clínic Universitari, Barcelona, Spain. [Rodríguez-Pardo D, Pigrau C] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sorlí L] Departament de Malalties Infeccioses, Parc de Salut Mar, Barcelona, Spain., and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Etiology, retrospective study, coagulase negative Staphylococcus, lcsh:Medicine, Prosthesis, Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores], medicine.disease_cause, 0302 clinical medicine, revision arthroplasty, equipos y suministros::prótesis e implantes::prótesis articulares [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], non-fermenting Gram-negative bacterium, Bacteroides, Medicine, Pròtesis, Microorganismes - Resistència als medicaments, 030212 general & internal medicine, Equipment and Supplies::Prostheses and Implants::Joint Prosthesis [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Candida, disease transmission, periprosthetic joint infection, biology, cons, immunosuppressive treatment, methicillin resistant Staphylococcus aureus, postoperative infection, Multidrug-Resistant Organisms, Articulacions artificials, General Medicine, Antimicrobial, Infeccions, infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones estafilocócicas [ENFERMEDADES], aged, female, risk factor, Staphylococcus aureus, Etiologia, Classification Schemes For Prosthetic Joint Infections, Articulacions - Cirurgia - Complicacions, fenómenos microbiológicos::fenómenos fisiológicos bacterianos::farmacorresistencia bacteriana::farmacorresistencia bacteriana múltiple [FENÓMENOS Y PROCESOS], Charlson Comorbidity Index, Gram positive cocci, prospective study, musculoskeletal diseases, Bacilli, Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial [PHENOMENA AND PROCESSES], Prosthetic joint, 030106 microbiology, microbial identification, bacterium culture, Virulence, Corynebacterium, Infections, Article, Mycobacterium, Microbiology, acute hematogenous infection, 03 medical and health sciences, Enterobacteriaceae, male, bacterium isolation, Other subheadings::Other subheadings::/adverse effects [Other subheadings], extended spectrum beta lactamase producing Enterobacteriaceae, Staphylococcus epidermidis, human, Propionibacterium acnes, bacteremia, Prosthetic Joint Infections, Antimicrobial Empirical Treatment, nonhuman, business.industry, bacterial virulence, lcsh:R, Infeccions per estafilococs, Streptococcus, biology.organism_classification, Classification schemes for prosthetic joint, major clinical study, Multiple drug resistance, osteoarthritis, multicenter study, arthroplasty, prosthesis implantation, Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Staphylococcal Infections [DISEASES], observational study, Microbial Etiology, business, Enterococcus
Abstract

The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)&mdash, including multidrug-resistant organisms (MDRO)&mdash, by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama&rsquo, s scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and &ldquo, positive intraoperative cultures&rdquo, (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: &lt, 1 month, 2&ndash, 3 months, 4&ndash, 12 months, &gt, 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.

Published
2019

38. Entomological surveillance with community engagement at Chagas Platform Centers for comprehensive care in the mesothermal valleys of three regions of the endemic area of Triatoma infestans in Bolivia

Author

Cortez, Mirko Rojas, primary, Pinazo, Maria-Jesus, additional, Pinto, Jimy, additional, Anzoleaga, Helmut Magne, additional, Caballero, Yurly Escobar, additional, Urioste, Gloria Sandy, additional, Sanchez, Jareth, additional, Castellon, Mario, additional, Garcia, Wilson, additional, Daza, Lourdes Ortiz, additional, Mur, Isabel Gonzales, additional, Lozano, Daniel, additional, Gascon, Joaquim, additional, and Torrico, Faustino, additional

Published
2019
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39. Rates and Predictors of Treatment Failure in Staphylococcus aureusProsthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G. E., Sorlí, Luisa, Murillo, Oscar, Soldevila, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W., Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesús, and del Toro, Maria Dolores

Abstract

Staphylococcus aureusis one of the most virulent bacteria and frequently causes prosthetic joint infections.

Published
2022
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40. Short- versus long-duration levofloxacin plus rifampicin for acute staphylococcal prosthetic joint infection managed with implant retention: a randomised clinical trial

Author

Murillo, Oscar, Ribera, Alba, Cabo, Xavier, Fresco, Gema, Ruiz-Garbajosa, Patricia, Leal, Joan, Puig, Luis, Sorlí, Luisa, Morata, Laura, Bori, Guillem, Martínez-Pastor, Juan C., Rodríguez-Pardo, Dolors, Puig-Asensio, Mireia, Sordé-Masip, Roger, Prats-Gispert, Laura, Pérez-Villar, Ferran, García-Gónzalez, Mercé, Esteban, Jaime, Blanco, Antonio, García-Cañete, Joaquín, Puente, Andrés, Domecq, Gabriel, Álvarez, Rocío, Peñas-Espinar, Cecilia, Muniain-Ezcurra, Miguel Ángel, Suárez, Ana-Isabel, Coll, Pere, Jordán, Marcos, Mur, Isabel, Ibarguren, Maialen, de la Herrán, Gaspar, Sánchez-Romero, Isabel, Jiménez-Cristóbal, Javier, Múñez-Rubio, Elena, Muntaner, Francisco, Ramírez, Antonio, Fariñas, María Carmen, Campo, Cristina, Fakkas, Michel, López-Azkarreta, Íñigo, Ibarra, Sofía, Cisterna, Ramón, Granados, Ana, Lora-Tamayo, Jaime, Euba, Gorane, Cobo, Javier, Horcajada, Juan Pablo, Soriano, Alex, Sandoval, Enrique, Pigrau, Carles, Benito, Natividad, Falgueras, Luis, Palomino, Julián, del Toro, María Dolores, Jover-Sáenz, Alfredo, Iribarren, José Antonio, Sánchez-Somolinos, Mar, Ramos, Antonio, Fernández-Sampedro, Marta, Riera, Melchor, Baraia-Etxaburu, Josu Mirena, and Ariza, Javier

Published
2016
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41. Pathogenesis of Staphylococcus epidermidis in prosthetic joint infections: Can identification of virulence genes differentiate between infecting and commensal strains?

Author

Sánchez, A., Benito, N., Rivera, A., García, L., Miró, E., Mur, I., González, Y., Gutiérrez, C., Horcajada, J.P., Espinal, P., Navarro, F., Sánchez, Alba, Benito, Natividad, Rivera, Alba, García, Lucas, Miró, Elisenda, Mur, Isabel, González, Yesica, Gutiérrez, Cristina, and Horcajada, Juan Pablo

Abstract

Background: Staphylococcus epidermidis is a commensal of human skin flora and a frequent causative microorganism in prosthetic joint infections (PJIs). To date, no single marker has been identified to distinguish infecting strains from commensal S. epidermidis populations.Aim: We aimed to find possible genetic markers to distinguish between the two populations.Methods: We analyzed 50 S. epidermidis strains from patients with PJIs, 50 from skin of healthy individuals (commensal strains) and 17 from the surgical field of patients undergoing primary arthroplasty. In these three groups we studied the antimicrobial susceptibility profile, sequence type, biofilm formation, and virulence factors. Strains from the surgical field have not been compared previously with strains from the other two groups.Findings: S. epidermidis strains from PJI patients were significantly more antibiotic resistant than commensal strains and surgical field strains. A wide variety of sequences types was found in commensal and surgical field strains. The predominant sequence type was ST2 and it was only present in PJI strains (44%). Differences in biofilm production did not differ between populations. Virulence genes sdrF and bhp, the complete ica operon, and the insertion sequence IS256 were significantly predominant in PJI strains. In contrast, embp and hld genes and the mobile element ACME were more prevalent in commensal strains. Surgical field strains could be a valid control group to discriminate between infecting and commensal strains.Conclusion: A combination of characteristic features can differentiate between infecting and commensal S. epidermidis strains in PJI, while a single marker cannot. [ABSTRACT FROM AUTHOR]

Published
2020
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42. Protocolo para una intervención fisioterápica precoz tras artroplastia total de rodilla

Author

Buil Mur, Isabel and Herranz Bercedo, Félix

Subjects
knee ostheoarthritis, arthroplasty, total knee, rehabilitation
Abstract

Introducción: la gonartrosis es una de las enfermedades que más invalidez ocasiona en las personas de mediana y/o mayor edad, llegando a producir limitaciones para las actividades básicas de la vida diaria. La técnica quirúrgica utilizada en los casos de que el tratamiento conservador no responda, es la artroplastia de rodilla, procedimiento con más expectativas de mejoría en cuanto a los síntomas del dolor y a la función física del paciente. El tratamiento fisioterápico precoz resulta imprescindible para conseguir los resultados óptimos perseguidos por esta intervención. Objetivos: la finalidad de este estudio es desarrollar un plan de intervención fisioterápica precoz, dirigido a pacientes intervenidos quirúrgicamente tras una artroplastia de rodilla. Metodología: se presenta un caso clínico de una mujer de 67 años de edad intervenida quirúrgicamente de prótesis total de rodilla debido a la gonartrosis. La paciente presenta limitación del movimiento, dolor, disminución de fuerza e incapacidad funcional. El tratamiento basado en medidas analgésicas, cinesiterapia, terapia manual y reeducación de la marcha fue aplicado durante un mes de duración. Desarrollo: la paciente tuvo una mejoría de sus síntomas, obteniéndose una disminución de 6 puntos en la escala EVA, aumentando considerablemente la amplitud articular tanto activa como pasiva y mejorando la fuerza muscular de la pierna intervenida. Los resultados del test de Tinneti, índice de Barthel y de los cuestionarios de WOMAC y SF-36 fueron satisfactorios. Conclusión: los resultados del tratamiento fisioterápico precoz basado en medidas cinesiterápicas, analgésicas, de terapia manual y de reeducación de la marcha para la recuperación de una prótesis total de rodilla, ha originado mejoras significativas en el rango de movilidad articular, disminución del dolor y en la vuelta a la deambulación funcional. Progreso que ha potenciado su buena calidad de vida final de la paciente.

Published
2014

43. Short- versus long-duration levofloxacin plus rifampicin for acute staphylococcal prosthetic joint infection managed with implant retention: a randomised clinical trial

Author

Lora-Tamayo, Jaime, primary, Euba, Gorane, additional, Cobo, Javier, additional, Horcajada, Juan Pablo, additional, Soriano, Alex, additional, Sandoval, Enrique, additional, Pigrau, Carles, additional, Benito, Natividad, additional, Falgueras, Luis, additional, Palomino, Julián, additional, del Toro, María Dolores, additional, Jover-Sáenz, Alfredo, additional, Iribarren, José Antonio, additional, Sánchez-Somolinos, Mar, additional, Ramos, Antonio, additional, Fernández-Sampedro, Marta, additional, Riera, Melchor, additional, Baraia-Etxaburu, Josu Mirena, additional, Ariza, Javier, additional, Murillo, Oscar, additional, Ribera, Alba, additional, Cabo, Xavier, additional, Fresco, Gema, additional, Ruiz-Garbajosa, Patricia, additional, Leal, Joan, additional, Puig, Luis, additional, Sorlí, Luisa, additional, Morata, Laura, additional, Bori, Guillem, additional, Martínez-Pastor, Juan C., additional, Rodríguez-Pardo, Dolors, additional, Puig-Asensio, Mireia, additional, Sordé-Masip, Roger, additional, Prats-Gispert, Laura, additional, Pérez-Villar, Ferran, additional, García-Gónzalez, Mercé, additional, Esteban, Jaime, additional, Blanco, Antonio, additional, García-Cañete, Joaquín, additional, Puente, Andrés, additional, Domecq, Gabriel, additional, Álvarez, Rocío, additional, Peñas-Espinar, Cecilia, additional, Muniain-Ezcurra, Miguel Ángel, additional, Suárez, Ana-Isabel, additional, Coll, Pere, additional, Jordán, Marcos, additional, Mur, Isabel, additional, Ibarguren, Maialen, additional, de la Herrán, Gaspar, additional, Sánchez-Romero, Isabel, additional, Jiménez-Cristóbal, Javier, additional, Múñez-Rubio, Elena, additional, Muntaner, Francisco, additional, Ramírez, Antonio, additional, Fariñas, María Carmen, additional, Campo, Cristina, additional, Fakkas, Michel, additional, López-Azkarreta, Íñigo, additional, Ibarra, Sofía, additional, Cisterna, Ramón, additional, and Granados, Ana, additional

Published
2016
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44. Rates and Predictors of Treatment Failure in Staphylococcus aureus Prosthetic Joint Infections According to Different Management Strategies: A Multinational Cohort Study—The ARTHR-IS Study Group

Author

Reinaldo, Espíndola, Venanzio, Vella, Natividad, Benito, Isabel, Mur, Sara, Tedeschi, Eleonora, Zamparini, Johannes G E, Hendriks, Luisa, Sorlí, Oscar, Murillo, Laura, Soldevila, Mathew, Scarborough, Claire, Scarborough, Jan, Kluytmans, Mateo Carlo, Ferrari, Mathias W, Pletz, Iain, Mcnamara, Rosa, Escudero-Sanchez, Cedric, Arvieux, Cecile, Batailler, Frédéric-Antoine, Dauchy, Wai-Yan, Liu, Jaime, Lora-Tamayo, Julia, Praena, Andrew, Ustianowski, Elisa, Cinconze, Michele, Pellegrini, Fabio, Bagnoli, Jesús, Rodríguez-Baño, Maria Dolores, Del Toro, Gabriella, Lindergard, Hospital Universitario Virgen Macarena [Séville], GlaxoSmithKline [Siena, Italy] (GSK), Hospital de la Santa Creu i Sant Pau, University of Bologna/Università di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Department of Orthopaedic Surgery and Trauma, Maxima MC, parent, IMIM-Hospital del Mar, Generalitat de Catalunya, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), John Radcliffe Hospital [Oxford University Hospital], Amphia Ziekenhuis = Amphia Hospital [Breda, The Netherlands] (AZ=AH), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Jena University Hospital [Jena], Norfolk and Norwich University Hospital, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Hôpital Sud [CHU Rennes], CHU Pontchaillou [Rennes], Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Centre Hospitalier Universitaire de Bordeaux (CHU de Bordeaux), Catharina Hospital, Hospital Universitario HM Sanchinarro [Madrid, Spain], Hospital Universitario Virgen del Rocío [Sevilla], North Manchester General Hospital, This work was supported by the Innovative Medicines Initiative Joint Undertaking (grant agreement No. 115523), COMBACTE-NET consortium (European Union FP7/2007–2013 and GlaxoSmithKline Biologicals SA, as EFPIA partner). European Development Regional Fund ‘‘A way to achieve Europe’’, Operative Program Intelligence Growth 2014-2020. The study sponsor is also funding the journal’s Rapid Service Fee., European Project: 115523,EC:FP7:SP1-JTI,IMI-JU-06-2012,COMBACTE(2013), European Commission, GlaxoSmithKline, European Federation of Pharmaceutical Industries and Associations, Red Española de Investigación en Patología Infecciosa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Espíndola, Reinaldo, Vella, Venanzio, Benito, Natividad, Mur, Isabel, Tedeschi, Sara, Zamparini, Eleonora, Hendriks, Johannes G E, Sorlí, Luisa, Murillo, Oscar, Soldevila, Laura, Scarborough, Mathew, Scarborough, Claire, Kluytmans, Jan, Ferrari, Mateo Carlo, Pletz, Mathias W, Mcnamara, Iain, Escudero-Sanchez, Rosa, Arvieux, Cedric, Batailler, Cecile, Dauchy, Frédéric-Antoine, Liu, Wai-Yan, Lora-Tamayo, Jaime, Praena, Julia, Ustianowski, Andrew, Cinconze, Elisa, Pellegrini, Michele, Bagnoli, Fabio, Rodríguez-Baño, Jesú, and Del Toro, Maria Dolores

Subjects
STAPHYLOCOCCUSAUREUS, Microbiology (medical), Staphylococcus aureus, Prosthetic joint infection, Infectious Diseases, Functional failure, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Clinical failure, Outcome
Abstract

[Introduction] Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess the incidence and risk factors for treatment failure (TF) of Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome., [Methods] A retrospective cohort study of SA-PJI was performed in 19 European hospitals between 2014 and 2016. The outcome variable was TF, including related mortality, clinical failure and functional loss both after the initial surgical procedure and after all procedures at 18 months. Predictors of TF were identified by logistic regression. Landmark analysis was used to avoid immortal time bias with rifampicin when debridement, antibiotics and implant retention (DAIR) was performed., [Results] One hundred twenty cases of SA-PJI were included. TF rates after the first and all surgical procedures performed were 32.8% and 24.2%, respectively. After all procedures, functional loss was 6.0% for DAIR and 17.2% for prosthesis removal. Variables independently associated with TF for the first procedure were Charlson ≥ 2, haemoglobin 30 kg/m2 and delay of DAIR, while rifampicin use was protective. For all procedures, the variables associated with TF were haemoglobin, [Conclusions] TF remains common in SA-PJI. Functional loss accounted for a substantial proportion of treatment failures, particularly after prosthesis removal. Use of rifampicin after DAIR was associated with a protective effect. Among the risk factors identified, anaemia and obesity have not frequently been reported in previous studies., [Trial registration] This study is registered at clinicaltrials.gov, registration no. NCT03826108., This work was supported by the Innovative Medicines Initiative Joint Undertaking (grant agreement No. 115523), COMBACTE-NET consortium (European Union FP7/2007–2013 and GlaxoSmithKline Biologicals SA, as EFPIA partner). R.E, L.S, O. M, R. E-S, J. L–T, J. P, J. R-B and MD. del T are members of the Spanish Network for Research in Infectious Diseases (REIPI), supported by Plan Nacional de I + D + i 2013‐2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001; 0002; 0005; 0009; 0011; 0015), co‐ financed by European Development Regional Fund “A way to achieve Europe”, Operative Program Intelligence Growth 2014‐2020.

Published
2022
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45. The Different Microbial Etiology of Prosthetic Joint Infections according to Route of Acquisition and Time after Prosthesis Implantation, Including the Role of Multidrug-Resistant Organisms.

Author

Benito N, Mur I, Ribera A, Soriano A, Rodríguez-Pardo D, Sorlí L, Cobo J, Fernández-Sampedro M, Del Toro MD, Guío L, Praena J, Bahamonde A, Riera M, Esteban J, Baraia-Etxaburu JM, Martínez-Alvarez J, Jover-Sáenz A, Dueñas C, Ramos A, Sobrino B, Euba G, Morata L, Pigrau C, Horcajada JP, Coll P, Crusi X, and Ariza J

Abstract

The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and "positive intraoperative cultures" (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: <1 month, 2-3 months, 4-12 months, >12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms ( S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.

Published
2019
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