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8. Étude de survie du traitement par omalizumab dans une cohorte multicentrique française de patients atteints d’urticaire chronique

Author

Litovsky, J., primary, Paryl, M., additional, Hacard, F., additional, Tétart, F., additional, Boccon Gibod, I., additional, Dezoteux, F., additional, Staumont-Sallé, D., additional, Darrigade, A.S., additional, Doutre, M.S., additional, Milpied, B., additional, Soria, A., additional, Amsler, E., additional, Bernier, C., additional, Perrot, J.L., additional, Raison Peyron, N., additional, Mura, T., additional, Grosjean, J., additional, and Du Thanh, A., additional

Published
2022
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13. Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

Author

Luque-Paz, David, Tattevin, Pierre, Loubet, Paul, Bénézit, François, Thibault, Vincent, Lainé, Fabrice, Vanhems, Philippe, Amour, Selilah, Lina, Bruno, Duval, Xavier, L’honneur, Anne-Sophie, Fidouh, Nadhira, Vallejo, Christine, Alain, Sophie, Galtier, Florence, Foulongne, Vincent, Lagathu, Gisèle, Lenzi, Nezha, Lesieur, Zineb, Launay, Odile, Jouneau, Stéphane, Loulergue, P., Momcilovic, S., Mira, J., Marin, N., Charpentier, J., Regent, A., Kanaan, R., Dumas, F., Doumenc, B., Lachatre, M., Szwebel, T., Kansao, J., Costa, Y., Alexandra, J., Becheur, H., Belghalem, K., Bernard, J., Bleibtreu, A., Boisseau, M., Bories, R., Brugiere, O., Brunet, F., Burdet, C., Casalino, E., Caseris, M., Chansiaux, C., Chauchard, M., Chavance, P., Choquet, C., Cloppet-Fontaine, A., Colosi, L., Couset, B., Crestani, B., Crocket, F., Debit, A., Delanoe, K, Descamps, V., Dieude, P., Dossier, A., Douron, N., Dupeyrat, E., Emeyrat, N., Fernet, C., Goulenok, T., Harent, S., Jouenne, R., Justet, A., Leleu, A., Lerat, I., Lilamand, M., Mal, H., Marceau, A., Metivier, A.-C., Oplelatora, K., Papo, T., Pelletier, A.-L., Pereira, L., Pradere, P., Prommier, R, Ralainnazava, P., Ranaivoision, M., Raynaud-Simon, A., Rioux, C., Sacre, K., Verry, V., Vuong, V., Yazdapanah, Y., Houhou, N., Géraud, P., Driss, V., Maugueret, V., Crantelle, L., Agostini, C., Ray, M., Letois, F., Mura, T., Serrand, C., Noslier, S., Giordano, A., Chevassus, H., Nyiramigisha, E., Merle, C., Bourdin, A., Konaté, A., Capdevilla, X., Du Cailar, G., Terminet, A., Blain, H., Leglise, M., Le Quellec, A., Corne, P., Landreau, L., Klouche, K., Bourgeois, A., Sebbane, M., Mourad, G., Leray, H., Postil, D., Alcolea, S., Couve-Deacon, E., Rogez, S., Argaud, L., Cour, M., Hernu, R., Simon, M., Baudry, T., Tazarourte, K., Bui-Xuan, C., Fattoum, J., Valette, M., Rochas, S., Cochennec, S., Thébault, E., Revest, M., Sébillotte, M., Le Bot, A., Baldeyrou, M., Patrat-Delon, S., Cailleaux, M., Pronier, C., CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Virulence Bactérienne et Infections Chroniques (VBIC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and This work was not funded. The study sites received funding from Sanofi Pasteur and MSD for the FLUVAC study. Vaccine producers had no role in the study design, data analysis, decision to publish or preparation of the manuscript.

Subjects
Adult, Multidisciplinary, [SDV]Life Sciences [q-bio], Respiratory Syncytial Virus Infections, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Adrenal Cortex Hormones, Virus Diseases, Respiratory Syncytial Virus, Human, Influenza, Human, Viruses, Humans, Prospective Studies, Respiratory Tract Infections
Abstract

Inhaled corticosteroids (ICS) have been associated with increased risk of pneumonia. Their impact on respiratory virus infections is unclear. We performed a post-hoc analysis of the FLUVAC cohort, a multicenter prospective cohort study of adults hospitalized with influenza-like illness (ILI) during six consecutive influenza seasons (2012–2018). All patients were tested for respiratory virus infection by multiplex PCR on nasopharyngeal swabs and/or bronchoalveolar lavage. Risk factors were identified by logistic regression analysis. Among the 2658 patients included, 537 (20.2%) were treated with ICS before admission, of whom 282 (52.5%, 282/537) tested positive for at least one respiratory virus. Patients on ICS were more likely to test positive for non-influenza respiratory viruses (25.1% vs. 19.5%, P = 0.004), especially for adenovirus (aOR 2.36, 95% CI 1.18–4.58), and respiratory syncytial virus (aOR 2.08, 95% CI 1.39–3.09). Complications were reported in 55.9% of patients on ICS (300/537), primarily pneumonia (171/535, 32%). Among patients on chronic ICS who tested positive for respiratory virus, 14.2% (40/282) were admitted to intensive care unit, and in-hospital mortality rate was 2.8% (8/282). Chronic use of ICS is associated with an increased risk of adenovirus or RSV infections in patients admitted for ILI.

Published
2021

22. Dermatoses inflammatoires péri-orificielles, du cuir chevelu et des plis survenant sous anti-TNF dans le cadre des maladies inflammatoires chroniques de l’intestin rôle de Staphylococcus aureus et des carences vitaminiques

Author

Schwob, E., primary, Dunyach-Remy, C., additional, Lavigne, J.-P., additional, Hoche, S., additional, Dereure, O., additional, Caillo, L., additional, Boivineau, L., additional, Bessis, D., additional, Girard, C., additional, Mura, T., additional, Altwegg, R., additional, and Du-Thanh, A., additional

Published
2020
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27. FRI0651-HPR A RANDOMIZED PROSPECTIVE OPEN-LABEL CONTROLLED TRIAL COMPARING THE PERFORMANCE OF A CONNECTED MONITORING INTERFACE IN PATIENTS WITH RHEUMATOID ARTHRITIS VERSUS PHYSICAL ROUTINE MONITORING

Author

Pers, Y. M., primary, Valsecchi, V., additional, Mura, T., additional, Aouinti, S., additional, Filippi, N., additional, Marouen, S., additional, Letaief, H., additional, Le Blay, P., additional, Autuori, M., additional, Fournet, D., additional, Mercier, G., additional, Ferreira Lopez, R., additional, and Jorgensen, C., additional

Published
2020
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31. RESPONSE OF QUASI-BRITTLE MATERIALS REINFORCED BY SHORT, ALIGNED FIBERS

Author

Ouyang, C., Shah, S.P., Mura, T., and Cheng, C.-J.

Subjects
Mechanical engineering -- Research, Strains and stresses -- Analysis, Fibrous composites -- Research, Cracking process -- Evaluation, Science and technology
Abstract

Pseudo-strain-hardening behavior of quasi-brittle materials reinforced by discontinuous, aligned fibers subjected to uniaxial tension is studied in this paper. An R-curve was used to describe transverse cracking of fiber-reinforced composites. The equivalent inclusion method and Mori-Tanaka theory were used to derive the strain energy release rate of the composites. The proposed model takes into account the influence of fiber distribution. When properties of fiber and matrix are known, the proposed model is capable of predicting whether or not a composite will fail with a single crack or multiple cracks. If a composite fails due to multiple cracks, the model can further predict its pseudo-strain-hardening behavior after the formation of the first transverse crack. The theoretical calculation reasonably matched the experimental results.

Published
1999

39. Constitutive equations of power-law composites and failure of materials having multiple cracks

Author

Lin, S.C., Hirose, y., and Mura, T.

Subjects
Composite materials -- Analysis, Fracture mechanics -- Analysis, Equations -- Analysis, Science and technology
Abstract

Mori-Tanaka method facilitates the analysis of constitutive equations of power-law composites and failure of materials having multiple cracks. Griffith fracture criterion calculates the critical volume fraction of multiple cracked materials, which leads to the failure of the material. Analyses of the reasons for failure of penny-shaped, flat, ellipsoidal and slit-like cracked materials show the linear relation between volume fraction of cracks and critical applied stress. Slit-like cracked body exhibits highest ductility while penny-shaped cracked body shows lowest ductility.

Published
1994

40. Micromechanics modeling of crack initiation under contact fatigue

Author

Cheng, W., Cheng, H.S., Mura, T., and Keer, L.M.

Subjects
Fracture mechanics -- Research, Micromechanics -- Models, Materials -- Fatigue, Science and technology
Abstract

Using dislocation pileup theory, a model is given for the prediction of crack initiation life under contact fatigue. Near surface crack initiation is investigated by introducing the sliding contact boundary condition. Crack initiation originated at the surface and substrate are treated as extreme cases. The new model physically explains how a surface crack can be initiated and shows that the surface crack initiation life should be shorter than the subsurface crack initiation life under the same stress amplitude conditions. A discussion is given about the influence of residual stress, hardness, temperature, irreversibility of the plastic deformation, as well as other parameters that affect the crack initiation life. Preliminary comparisons show that the new model agrees well with the experimental observations of surface and near surface crack initiation.

Published
1994

41. Sliding inclusions and inhomogeneities with frictional interfaces

Author

Furuhashi, R., Huang, Jin H., and Mura, T.

Subjects
Friction -- Analysis, Shear (Mechanics) -- Research, Science and technology
Abstract

The inclusion and inhomogeneity problems with frictional interfaces are investigated. Three cases involving a spherical inclusion, a nondegenerate ellipsoidal inclusion and a nondegenerate ellipsoidal inhomogeneity subjected to different eigenstrain and shear conditions are used in the study. These dynamic systems are solved using the equivalent inclusion method. Results show that the nature of the eigenstrains has significant effects on the behavior of the inclusion.

Published
1992

43. P165 Molecular and cellular biomarkers that discriminate juvenile idiopathic arthritis from septic arthritis

Author

Nziza, N, primary, Cren, M, additional, Carbasse, A, additional, Mahe, P, additional, Delpont, M, additional, Sabah, D, additional, Chevassus, H, additional, Khalil, M, additional, Mura, T, additional, Jorgensen, C, additional, Plence, P, additional, Jeziorski, E, additional, Duroux-Richard, I, additional, and Apparailly, F, additional

Published
2019
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44. Speckle tracking echocardiography in children with Duchenne muscular dystrophy: A multicenter controlled cross-sectional study

Author

Amedro, P., primary, Vincenti, M., additional, De La Villeon, G., additional, Lavastre, K., additional, Barrea, C., additional, Guillaumont, S., additional, Bredy, C., additional, Meli, Albano, additional, Cazorla, Olivier, additional, Fauconnier, Jérémy, additional, Meyer, P., additional, Rivier, F., additional, Adda, J., additional, Mura, T., additional, and Lacampagne, Alain, additional

Published
2019
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48. Is gene panel sequencing more efficient than clinical‐based gene sequencing to diagnose autoinflammatory diseases? A randomized study.

Author

Rama, M., Mura, T., Kone‐Paut, I., Boursier, G., Aouinti, S., Touitou, I., and Sarrabay, G.

Subjects
*GENETIC mutation, *MEDICAL care, *HUMAN chromosome abnormality diagnosis, *GENES, *DIAGNOSIS, *AUTOINFLAMMATORY diseases
Abstract

Summary: The aim of this study was to compare the effectiveness of the gene‐panel next‐generation sequencing (NGS) strategy versus the clinical‐based gene Sanger sequencing for the genetic diagnosis of autoinflammatory diseases (AIDs). Secondary goals were to describe the gene and mutation distribution in AID patients and to evaluate the impact of the genetic report on the patient's medical care and treatment. Patients with AID symptoms were enrolled prospectively and randomized to two arms, NGS (n = 99) (32–55 genes) and Sanger sequencing (n = 197) (one to four genes). Genotypes were classified as 'consistent/confirmatory', 'uncertain significance' or 'non‐contributory'. The proportion of patients with pathogenic genotypes concordant with the AID phenotype (consistent/confirmatory) was significantly higher with NGS than Sanger sequencing [10 of 99 (10·1%) versus eight of 197 (4·1%)]. MEFV, ADA2 and MVK were the most represented genes with a consistent/confirmed genotype, whereas MEFV, NLRP3, NOD2 and TNFRSF1A were found in the 'uncertain significance' genotypes. Six months after the genetic report was sent, 54 of 128 (42·2%) patients had received effective treatment for their symptoms; 13 of 128 (10·2%) had started treatment after the genetic study. For 59 of 128 (46%) patients, the results had an impact on their overall care, independent of sequencing group and diagnostic conclusion. Targeted NGS improved the diagnosis and global care of patients with AIDs. [ABSTRACT FROM AUTHOR]

Published
2021
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