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2. Underwater Endoscopic Mucosal Resection Vs Conventional Endoscopic Mucosal Resection for Superficial Nonampullary Duodenal Epithelial Tumors in the Western Setting

Author

Morais, Rui, Amorim, José, Medas, Renato, Sousa-Pinto, Bernardo, Santos-Antunes, João, Legros, Romain, Albouys, Jérémie, Moll, Frédéric, Marques, Margarida, Vilas-Boas, Filipe, Rodrigues-Pinto, Eduardo, Gullo, Irene, Carneiro, Fátima, Soares, Elisa Gravito, Amaro, Pedro, Mesquita, Pedro, Rodrigues, Jaime, Andrisani, Gianluca, Sferrazza, Sandro, Archer, Sara, Kuttner-Magalhães, Ricardo, Manzano, Francisco, de Santiago, Enrique Rodríguez, Rimondi, Alessandro, Murino, Alberto, Despott, Edward, Pioche, Mathieu, Jacques, Jérémie, and Macedo, Guilherme

Published
2025
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3. Endoscopic submucosal dissection for rectal neuroendocrine tumours: A multicentric retrospective study

Author

Rimondi, Alessandro, Despott, Edward J, Chacchi, Rocio, Lazaridis, Nikolaos, Costa, Deborah, Bucalau, Ana-Maria, Mandair, Dalvinder, Pioche, Mathieu, Rivory, Jérome, Santos-Antunes, Joao, Marques, Margarida, Ramos-Zabala, Felipe, Barbaro, Federico, Pimentel-Nunes, Pedro, Dinis-Ribeiro, Mario, Albeniz, Eduardo, Tantau, Marcel, Spada, Cristiano, Lemmers, Arnaud, Caplin, Martyn, Toumpanakis, Christos, and Murino, Alberto

Published
2024
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6. AI-assisted capsule endoscopy reading in suspected small bowel bleeding: a multicentre prospective study

Author

Spada, Cristiano, Piccirelli, Stefania, Hassan, Cesare, Ferrari, Clarissa, Toth, Ervin, González-Suárez, Begoña, Keuchel, Martin, McAlindon, Marc, Finta, Ádám, Rosztóczy, András, Dray, Xavier, Salvi, Daniele, Riccioni, Maria Elena, Benamouzig, Robert, Chattree, Amit, Humphries, Adam, Saurin, Jean-Christophe, Despott, Edward J, Murino, Alberto, Johansson, Gabriele Wurm, Giordano, Antonio, Baltes, Peter, Sidhu, Reena, Szalai, Milan, Helle, Krisztina, Nemeth, Artur, Nowak, Tanja, Lin, Rong, and Costamagna, Guido

Published
2024
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10. Underwater EMR versus conventional EMR for superficial non-ampullary duodenal epithelial tumors in the Western setting

Author

Morais, Rui, primary, Amorim, José, additional, Medas, Renato, additional, Sousa-Pinto, Bernardo, additional, Santos-Antunes, João, additional, Legros, Romain, additional, Albouys, Jérémie, additional, Moll, Frédéric, additional, Marques, Margarida, additional, Vilas-Boas, Filipe, additional, Rodrigues-Pinto, Eduardo, additional, Gullo, Irene, additional, Carneiro, Fátima, additional, Soares, Elisa Gravito, additional, Amaro, Pedro, additional, Mesquita, Pedro, additional, Rodrigues, Jaime, additional, Andrisani, Gianluca, additional, Sferrazza, Sandro, additional, Archer, Sara, additional, Kuttner-Magalhães, Ricardo, additional, Manzano, Francisco, additional, Rodríguez de Santiago, Enrique, additional, Rimondi, Alessandro, additional, Murino, Alberto, additional, Despott, Edward, additional, Pioche, Mathieu, additional, Jacques, Jérémie, additional, and Macedo, Guilherme, additional

Published
2024
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12. Multicenter cohort study of patients with buried bumper syndrome treated endoscopically with a novel, dedicated device

Author

Costa, Deborah, Despott, Edward J., Lazaridis, Nikolaos, Woodward, Jeremy, Kohout, Pavel, Rath, Timo, Scovell, Louise, Gee, Ian, Hindryckx, Pieter, Forrest, Ewan, Hollywood, Coral, Hearing, Stephen, Mohammed, Imtiyaz, Coppo, Claudia, Koukias, Nikolaos, Cooney, Rachel, Sharma, Hemant, Zeino, Zeino, Gooding, Ian, and Murino, Alberto

Published
2021
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14. Efficacy and Safety of Cryoablation in Barrett's Esophagus and Comparison with Radiofrequency Ablation: A Meta-Analysis.

Author

Papaefthymiou, Apostolis, Norton, Benjamin, Telese, Andrea, Ramai, Daryl, Murino, Alberto, Gkolfakis, Paraskevas, Vargo, John, and Haidry, Rehan J.

Subjects
PATIENT safety, NEOPLASTIC cell transformation, DISEASE eradication, RADIO frequency therapy, CRYOSURGERY, TREATMENT effectiveness, META-analysis, DESCRIPTIVE statistics, SYSTEMATIC reviews, MEDLINE, ODDS ratio, METAPLASIA, MEDICAL databases, BARRETT'S esophagus, CATHETER ablation, CONFIDENCE intervals, ESOPHAGEAL stenosis
Abstract

Simple Summary: Cryoablation therapy is an emerging modality in the treatment of Barrett's esophagus. Our systematic review collected data on this technique to provide evidence of its efficacy and safety and to compare it with the established RFA. The results from twenty-three studies revealed that the complete eradication of dysplasia and intestinal metaplasia was comparable between RFA and cryoablation. More specifically, cryoablation achieved a complete eradication of dysplasia and intestinal metaplasia at rates of 84.2% (95%CI: 79.1–89.3) and 64.1% (95%CI: 49.2–79.0), respectively, whereas 8.3% (95%CI: 4.7–11.9) of cases presented with recurrence. Studies on cryoballoons seem to be more homogenous in terms of dysplasia treatment, complications, and, especially, strictures. Background: The mainstay approach in endoscopic eradication therapy (EET) for dysplastic Barrett's esophagus (BE) includes the endoscopic resection of visible lesions, accompanied by ablation of the residual metaplastic epithelium. Cryoablation therapy is one such emerging ablation technique in this field. This systematic review with a meta-analysis aims to accumulate pooled data on cryoablation performance in the treatment of patients with BE and to compare this technique to the standard of care radiofrequency ablation (RFA). Methods: The MEDLINE, Cochrane, and Scopus databases were searched until June 2024 for studies evaluating BE management using cryoablation for cumulative results. The primary outcome was the complete eradication of dysplasia (CED) and intestinal metaplasia (CEIM) in BE compared to RFA, while secondary outcomes included the respective pooled rates using cryoablation, recurrence, and adverse events, with a separate analysis for strictures. The meta-analyses were based on a random-effects model, and the results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Subgroup analyses by type of cryoablation were also performed. Results: Twenty-three studies (1604 patients) were finally included, four of which were comparative. CED and CEIM did not differ significantly between cryoablation and RFA [OR= 0.95 (95%CI: 0.50–1.81) and OR = 0.57 (95%CI: 0.20–1.63), respectively)]. The pooled rates of CED, CEIM, and recurrence after cryoablation were 84.2% (95%CI: 79.1–89.3), 64.1% (95%CI: 49.2–79.0), and 8.3% (95%CI: 4.7–11.9), accompanied by high rates of heterogeneity. Adverse events were noted in 14.5% (95%CI: 9.9–19.2) of cases, and 6.5% (95%CI: 4.1–9.0) developed strictures. In the subgroup analysis, the cryoballoon achieved a reduction in heterogeneity in CED, adverse events, and stricture formation, whereas spray catheters provided homogenous results in terms of recurrence. Conclusions: Cryoablation provides equal outcomes compared to RFA in the treatment of patients with BE, with the cryoballoon achieving relatively homogenous rates of CED and adverse events. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Hemospray® (Hemostatic powder TC-325) as monotherapy for acute gastrointestinal bleeding: a multi-center prospective study

Author

Papaefthymiou, Apostolis, primary, Aslam, Nasar, additional, Hussein, Mohamed, additional, Alzoubaidi, Durayd, additional, Gross, Seth A, additional, Serna, Alvaro De La, additional, Varbobitis, Ioannis, additional, Hengehold, Tricia A., additional, López, Miguel Fraile, additional, Fernández-Sordo, Jacobo Ortiz, additional, Rey, Johannes W., additional, Hayee, Bu, additional, Despott, Edward J., additional, Murino, Alberto, additional, Moreea, Sulleman, additional, Boger, Phil, additional, Dunn, Jason M., additional, Mainie, Inder, additional, Mullady, Daniel, additional, Early, Dayna, additional, Latorre, Melissa, additional, Ragunath, Krish, additional, Anderson, John T., additional, Bhandari, Pradeep, additional, Goetz, Martin, additional, Kiesslich, Ralf, additional, Coron, Emmanuel, additional, De Santiago, Enrique Rodríguez, additional, Gonda, Tamas A., additional, O'Donnell, Michael, additional, Norton, Benjamin, additional, Telese, Andrea, additional, Simons-Linares, Roberto, additional, and Haidry, Rehan J, additional

Published
2024
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22. Endoscopic Management of Gastro-Entero-Pancreatic Neuroendocrine Tumours: An Overview of Proposed Resection and Ablation Techniques

Author

Chacchi-Cahuin, Rocio, primary, Despott, Edward J., additional, Lazaridis, Nikolaos, additional, Rimondi, Alessandro, additional, Fusai, Giuseppe Kito, additional, Mandair, Dalvinder, additional, Anderloni, Andrea, additional, Sciola, Valentina, additional, Caplin, Martyn, additional, Toumpanakis, Christos, additional, and Murino, Alberto, additional

Published
2024
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24. Hemospray® (hemostatic powder TC-325) as monotherapy for acute gastrointestinal bleeding: a multicenter prospective study.

Author

Papaefthymiou, Apostolis, Aslam, Nasar, Hussein, Mohamed, Alzoubaidi, Durayd, Gross, Seth A., De La Serna, Alvaro, Varbobitis, Ioannis, Hengehold, Tricia A., Fraile López, Miguel, Fernández-Sordo, Jacobo Ortiz, Rey, Johannes W., Hayee, Bu, Despott, Edward J., Murino, Alberto, Moreea, Sulleman, Boger, Phil, Dunn, Jason M., Mainie, Inder, Mullady, Daniel, and Early, Dayna

Subjects
PEPTIC ulcer, HEMOSTASIS, STATISTICAL significance, CONFIDENCE intervals, HEMORRHAGE, GASTROINTESTINAL hemorrhage
Abstract

Background Hemostatic powders are used as second-line treatment in acute gastrointestinal (GI) bleeding (AGIB). Increasing evidence supports the use of TC-325 as monotherapy in specific scenarios. This prospective, multicenter study evaluated the performance of TC-325 as monotherapy for AGIB. Methods Eighteen centers across Europe and USA contributed to a registry between 2016 and 2022. Adults with AGIB were eligible, unless TC-325 was part of combined hemostasis. The primary endpoint was immediate hemostasis. Secondary outcomes were rebleeding and mortality. Associations with risk factors were investigated (statistical significance at P=0.05). Results One hundred ninety patients were included (age 51-81 years, male: female 2:1), with peptic ulcer (n=48), upper GI malignancy (n=79), post-endoscopic treatment hemorrhage (n=37), and lower GI lesions (n=26). The primary outcome was recorded in 96.3% (95% confidence interval [CI]: 92.6-98.5) with rebleeding in 17.4% (95%CI 11.9-24.1); 9.9% (95%CI 5.8-15.6) died within 7 days, and 21.7% (95%CI 15.6-28.9) within 30 days. Regarding peptic ulcer, immediate hemostasis was achieved in 88% (95%CI 75-95), while 26% (95%CI 13-43) rebled. Higher ASA score was associated with mortality (OR 23.5, 95%CI 1.60-345; P=0.02). Immediate hemostasis was achieved in 100% of cases with malignancy and post-intervention bleeding, with rebleeding in 17% and 3.1%, respectively. Twenty-six patients received TC-325 for lower GI bleeding, and in all but one the primary outcome was achieved. Conclusions TC-325 monotherapy is safe and effective, especially in malignancy or postendoscopic intervention bleeding. In patients with peptic ulcer, it could be helpful when the primary treatment is unfeasible, as bridge to definite therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Device-assisted enteroscopy performance measures in the United Kingdom: DEEP-UK quality improvement project

Author

Despott, Edward J., primary, Sanders, David S., primary, Shiha, Mohamed G., additional, Sidhu, Reena, additional, Lucaciu, Laura A., additional, Palmer-Jones, Christopher, additional, Ayeboa-Sallah, Benjamin, additional, Lazaridis, Nikolaos, additional, Eckersley, Robert, additional, Hiner, George E., additional, Maxfield, Dominic, additional, Shaheen, Walaa, additional, Abduljabbar, Duaa, additional, Hussain, Muhammad A., additional, O’Hare, Rosie, additional, Phull, Perminder S., additional, Eccles, John, additional, Caddy, Grant R., additional, Butt, Mohammed A., additional, Kurup, Arun, additional, Chattree, Amit, additional, Hoare, Jonathan, additional, Jennings, Jason, additional, Longcroft-Wheaton, Gaius, additional, Collins, Paul, additional, Humphries, Adam, additional, and Murino, Alberto, additional

Published
2023
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30. Treatment options for gastrointestinal bleeding blue rubber bleb nevus syndrome: Systematic review.

Author

Rimondi, Alessandro, Sorge, Andrea, Murino, Alberto, Nandi, Nicoletta, Scaramella, Lucia, Vecchi, Maurizio, Tontini, Gian Eugenio, and Elli, Luca

Subjects
GASTROINTESTINAL hemorrhage, NEVUS, DRUG therapy, RUBBER, SYNDROMES, THERAPEUTICS
Abstract

Objectives: Blue rubber bleb nevus syndrome (BRBNS) is a rare challenging cause of gastrointestinal bleeding. We performed a systematic review of case reports and case series on BRBNS to gather information on the treatment options currently available. Methods: All studies reporting a case of BRBNS in humans were evaluated. Papers were ruled out if CARE criteria and explanations on patient's selection, ascertainment, causality, and reporting were not respected or identified. PROSPERO 2021 CRD 42021286982. Results: Blue rubber bleb nevus syndrome was treated in 106 cases from 76 reports. 57.5% of the population was under 18 years old, and up to 50% of the cases reported a previous treatment. Clinical success was achieved in 98 patients (92.4%). Three main types of interventions were identified: systemic drug therapy, endoscopy, and surgery. After BRBNS recurrence or previous therapy failure, systemic drug therapy emerged as a preferred second‐line treatment over endoscopy (P = 0.01), but with a higher rate of reported adverse events when compared with surgery and endoscopy (P < 0.001). Endoscopic treatment was associated with a higher number of required sessions to achieve complete eradication when compared with surgery (P < 0.001). No differences between the three main areas were found in the overall follow‐up time (P = 0.19) or in the recurrence rate (P = 0.45). Conclusion: Endoscopy, surgery, and systemic drug therapy are feasible treatment options for BRBNS. Systemic drug therapy was the favorite second‐line treatment after endoscopic failure or recurrence of BRBNS, but adverse events were more frequently reported. [ABSTRACT FROM AUTHOR]

Published
2024
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31. ARTIFICIAL INTELLIGENCE-ASSISTED SMALL BOWEL CAPSULE ENDOSCOPY READING IN PATIENTS WITH SUSPECTED SMALL BOWEL BLEEDING

Author

Piccirelli, Stefania, primary, Hassan, Cesare, additional, Ferrari, Clarissa, additional, Toth, Ervin, additional, Suárez, Begoña González, additional, Keuchel, Martin, additional, McAlindon, Mark, additional, Finta, Adam, additional, Rosztóczy, Andras, additional, Dray, Xavier, additional, Salvi, Daniele, additional, Riccioni, Maria Elena, additional, Benamouzig, Robert, additional, Chattree, Amit, additional, Saurin, Jean-Christophe, additional, Humphries, Adam, additional, Despott, Edward, additional, Murino, Alberto, additional, Johansson, Gabriele, additional, Giordano, Antonio, additional, Baltes, Peter, additional, Sidhu, Reena, additional, Szalai, Milan, additional, Helle, Krisztina, additional, Nemeth, Artur, additional, Nowak, Tanja, additional, Lin, Rong, additional, Costamagna, Guido, additional, and Spada, Cristiano, additional

Published
2023
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41. Performance measures for colonoscopy in inflammatory bowel disease patients: European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative

Author

Dekker, Evelien, primary, Nass, Karlijn J., primary, Iacucci, Marietta, additional, Murino, Alberto, additional, Sabino, João, additional, Bugajski, Marek, additional, Carretero, Cristina, additional, Cortas, George, additional, Despott, Edward J., additional, East, James E., additional, Kaminski, Michal F., additional, Karstensen, John Gásdal, additional, Keuchel, Martin, additional, Löwenberg, Mark, additional, Monged, Ashraf, additional, Nardone, Olga M., additional, Neumann, Helmut, additional, Omar, Mahmoud M., additional, Pellisé, Maria, additional, Peyrin-Biroulet, Laurent, additional, Rutter, Matthew D., additional, and Bisschops, Raf, additional

Published
2022
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43. ENDOSCOPIC OUTCOMES FOR PATIENTS TREATED WITH HEMOSPRAY FOR ACUTE GASTROINTESTINAL BLEEDING HAVE CHANGED OVER TIME: RESULTS FROM A 5-YEAR INTERNATIONAL MULTICENTRE REGISTRY

Author

Aslam, Nasar, primary, Hussein, Mohamed, additional, Alzoubaidi, Durayd, additional, O'Donnell, Michael, additional, De La Serna, Alvaro, additional, Varbobitis, Ioannis, additional, Hengehold, Tricia A., additional, López, Miguel Fraile, additional, Fernández-Sordo, Jacobo Ortiz, additional, Rey, Johannes W., additional, Hayee, Bu, additional, Despott, Edward J., additional, Murino, Alberto, additional, Moreea, Sulleman, additional, Boger, Phil, additional, Dunn, Jason M., additional, Mainie, Inder, additional, Graham, David, additional, Mullady, Dan, additional, Early, Dayna, additional, Latorre, Melissa, additional, Ragunath, Krish, additional, Anderson, John T., additional, Goetz, Martin, additional, Kiesslich, Ralf, additional, Coron, Emmanuel, additional, De Santiago, Enrique Rodriguez, additional, Gonda, Tamas A., additional, Gross, Seth, additional, Lovat, Laurence B., additional, Haidry, Rehan, additional, and Bhandari, Pradeep, additional

Published
2022
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44. ENDOSCOPIC APPLICATION OF HEMOSPRAY AS MONOTHERAPHY IN THE TREATMENT OF ACUTE GASTROINTESTINAL BLEEDING: OUTCOMES FROM A 5-YEAR INTERNATIONAL MULTICENTRE REGISTRY

Author

Aslam, Nasar, primary, Hussein, Mohamed, additional, Alzoubaidi, Durayd, additional, O'Donnell, Michael, additional, De La Serna, Alvaro, additional, Varbobitis, Ioannis, additional, Hengehold, Tricia A., additional, López, Miguel Fraile, additional, Fernández-Sordo, Jacobo Ortiz, additional, Rey, Johannes W., additional, Hayee, Bu, additional, Despott, Edward J., additional, Murino, Alberto, additional, Moreea, Sulleman, additional, Boger, Phil, additional, Dunn, Jason M., additional, Mainie, Inder, additional, Graham, David G., additional, Mullady, Dan, additional, Early, Dayna, additional, Latorre, Melissa, additional, Ragunath, Krish, additional, Anderson, John T., additional, Bhandari, Pradeep, additional, Goetz, Martin, additional, Kiesslich, Ralf, additional, Coron, Emmanuel, additional, De Santiago, Enrique R., additional, Gonda, Tamas A., additional, Gross, Seth, additional, Lovat, Laurence B., additional, and Haidry, Rehan, additional

Published
2022
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45. Performance measures for colonoscopy in inflammatory bowel disease patients:European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative

Author

Dekker, Evelien, Nass, Karlijn J., Iacucci, Marietta, Murino, Alberto, Sabino, João, Bugajski, Marek, Carretero, Cristina, Cortas, George, Despott, Edward J., East, James E., Kaminski, Michal F., Karstensen, John Gásdal, Keuchel, Martin, Löwenberg, Mark, Monged, Ashraf, Nardone, Olga M., Neumann, Helmut, Omar, Mahmoud M., Pellisé, Maria, Peyrin-Biroulet, Laurent, Rutter, Matthew D., Bisschops, Raf, Dekker, Evelien, Nass, Karlijn J., Iacucci, Marietta, Murino, Alberto, Sabino, João, Bugajski, Marek, Carretero, Cristina, Cortas, George, Despott, Edward J., East, James E., Kaminski, Michal F., Karstensen, John Gásdal, Keuchel, Martin, Löwenberg, Mark, Monged, Ashraf, Nardone, Olga M., Neumann, Helmut, Omar, Mahmoud M., Pellisé, Maria, Peyrin-Biroulet, Laurent, Rutter, Matthew D., and Bisschops, Raf

Abstract

The European Society of Gastrointestinal Endoscopy (ESGE) presents a short list of performance measures for colonoscopy in inflammatory bowel disease (IBD) patients. Current performance measures for colonoscopy mainly focus on detecting (pre)malignant lesions. However, these performance measures are not relevant for all colonoscopy indications in IBD patients. Therefore, our aim was to provide endoscopy services across Europe and other interested countries with a tool for quality monitoring and improvement in IBD colonoscopy. Eight key performance measures and one minor performance measure were recommended for measurement and evaluation in daily endoscopy practice.

Published
2022

47. PTH-1 Small-bowel neuroendocrine tumours: the role of double-balloon-enteroscopy. A case series from a tertiary referral centre

Author

Magalhães, Rui de Sousa, primary, Murino, Alberto, additional, Skamnelos, Alexandros, additional, Cahuin, Rocio Chacchi, additional, Telese, Andrea, additional, Phillips, Edward, additional, Laskaratos, Faidon-Marios, additional, Luong, TuVinh, additional, Watkins, Jennifer, additional, Koukias, Nikolaos, additional, Raymond, Regina, additional, Lazaridis, Nikolaos, additional, Mandair, Dalvinder, additional, Toumpanakis, Christos, additional, Caplin, Martyn E, additional, and Despott, Edward J, additional

Published
2021
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49. PTU-24 The role of Hemospray as a monotherapy treatment of Gastrointestinal bleeds

Author

Hussein, Mohamed, primary, Alzoubaidi, Durayd, additional, O’Donnell, Michael, additional, Serna, Alvaro de la, additional, Varbobitis, Iooannis, additional, Hengehold, Tricia, additional, Fernandez-Sordo, Jacobo Ortiz, additional, Rey, Johannes W, additional, Hayee, Bu, additional, Despott, Edward, additional, Murino, Alberto, additional, Moreea, Sulleman, additional, Boger, Phil, additional, Dunn, Jason, additional, Mainie, Inder, additional, Graham, David, additional, Mullady, Daniel, additional, Early, Dayna, additional, Latorre, Melissa, additional, Ragunath, Krish, additional, Anderson, John, additional, Bhandari, Pradeep, additional, Goetz, Martin, additional, Keisslich, Ralf, additional, Coron, Emmanuel, additional, Santiago, Enrique Rodriguez de, additional, Gonda, Tamas, additional, Gross, Seth, additional, Lovat, Laurence, additional, and Haidry, Rehan, additional

Published
2021
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