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205 results on '"Murovska M"'

11. Autonomic Phenotypes in Chronic Fatigue Syndrome (CFS) Are Associated with Illness Severity: A Cluster Analysis

Author

Slomko, J., Estevez-Lopez, F., Kujawski, S., Zawadka-Kunikowska, M., Tafil-Klawe, M., Klawe, J.J., Morten, K.J., Szrajda, J., Murovska, M., Newton, J.L., Zalewski, P., Slomko, J., Estevez-Lopez, F., Kujawski, S., Zawadka-Kunikowska, M., Tafil-Klawe, M., Klawe, J.J., Morten, K.J., Szrajda, J., Murovska, M., Newton, J.L., and Zalewski, P.

Abstract

In this study we set out to define the characteristics of autonomic subgroups of patients with Chronic Fatigue Syndrome (CFS). The study included 131 patients with CFS (Fukuda criteria). Participants completed the following screening symptom assessment tools: Chalder Fatigue Scale, Fatigue Impact Scale, Fatigue Severity Scale, Epworth Sleepiness Scales, the self-reported Composite Autonomic Symptom Scale. Autonomic parameters were measured at rest with a Task Force Monitor (CNS Systems) and arterial stiffness using an Arteriograph (TensioMed Kft.). Principal axis factor analysis yielded four factors: fatigue, subjective and objective autonomic dysfunction and arterial stiffness. Using cluster analyses, these factors were grouped in four autonomic profiles: 34% of patients had sympathetic symptoms with dysautonomia, 5% sympathetic alone, 21% parasympathetic and 40% had issues with sympathovagal balance. Those with a sympathetic-dysautonomia phenotype were associated with more severe disease, reported greater subjective autonomic symptoms with sympathetic over-modulation and had the lowest quality of life. The highest quality of life was observed in the balance subtype where subjects were the youngest, had

Published
2020
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12. Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology

Author

Estevez-Lopez, F., Mudie, K., Wang-Steverding, X., Bakken, I.J., Ivanovs, A., Castro-Marrero, J., Nacul, L., Alegre, J., Zalewski, P., Slomko, J., Strand, E.B., Pheby, D., Shikova, E., Lorusso, L., Capelli, E., Sekulic, S., Scheibenbogen, C. (Carmen), Sepulveda, N., Murovska, M., Lacerda, E., Estevez-Lopez, F., Mudie, K., Wang-Steverding, X., Bakken, I.J., Ivanovs, A., Castro-Marrero, J., Nacul, L., Alegre, J., Zalewski, P., Slomko, J., Strand, E.B., Pheby, D., Shikova, E., Lorusso, L., Capelli, E., Sekulic, S., Scheibenbogen, C. (Carmen), Sepulveda, N., Murovska, M., and Lacerda, E.

Abstract

This review aimed at determining the prevalence and incidence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in Europe. We conducted a primary search in Scopus, PubMed and Web of Science for publications between 1994 and 15 June 2019 (PROSPERO: CRD42017078688). Additionally, we performed a backward-(reference lists) and forward-(citations) search of the works included in this review. Grey literature was addressed by contacting all members of the European Network on ME/CFS (EUROMENE). Independent reviewers searched, screened and selected studies, extracted data and evaluated the methodological and reporting quality. For prevalence, two studies in adults and one study in adolescents were included. Prevalence ranged from 0.1% to 2.2%. Two studies also included incidence estimates. In conclusion, studies on the prevalence and incidence of ME/CFS in Europe were scarce. Our findings point to the pressing need for well-designed and statistically powered epidemiological studies. To overcome the shortcomings of the current state-of-the-art, EUROMENE recommends that future research is better conducted in the community, reviewing the clinical history of potential cases, obtaining additional objective information (when needed) and using adequate ME/CFS case definitions; namely, the Centers for Disease Control & Prevention−1994, Canadian Consensus Criteria, or Institute of Medicine criteria.

Published
2020
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14. Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology

Author

Estévez López, Fer, Mudie, K, Wang-Steverding, X, Bakken, IJ, Ivanovs, A, Castro-Marrero, J, Nacul, L, Alegre, J, Zalewski, P, Slomko, J, Strand, EB, Pheby, D, Shikova, E, Lorusso, L, Capelli, E, Sekulic, S, Scheibenbogen, C, Sepulveda, N, Murovska, M, Lacerda, E, Estévez López, Fer, Mudie, K, Wang-Steverding, X, Bakken, IJ, Ivanovs, A, Castro-Marrero, J, Nacul, L, Alegre, J, Zalewski, P, Slomko, J, Strand, EB, Pheby, D, Shikova, E, Lorusso, L, Capelli, E, Sekulic, S, Scheibenbogen, C, Sepulveda, N, Murovska, M, and Lacerda, E

Published
2020

19. Tissue engineering of heart valve leaflet by self-assembly of tissue spheroids biofabricated from human fat tissue derived stem cells

Author

Mironov, V., primary, Kasyanov, V., additional, Nagy-Mehesz, A., additional, Moreno, R., additional, Hajdu, Z., additional, Trusk, T., additional, Ozolanta, I., additional, Murovska, M., additional, Wu, Y., additional, Yao, H., additional, Beachley, V., additional, Wen, X., additional, Bradshaw, A., additional, Visconti, R., additional, Norris, R., additional, and Markwald, R., additional

Published
2009
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20. Myalgic encephalomyelitis: International Consensus Criteria

Author

Carruthers, B. M., van de Sande, M. I., De Meirleir, K. L., Klimas, N. G., Broderick, G., Mitchell, T., Staines, D., Powles, A. C. P., Speight, N., Vallings, R., Bateman, L., Baumgarten-Austrheim, B., Bell, D. S., Carlo-Stella, N., Chia, J., Darragh, A., Jo, D., Lewis, D., Light, A. R., Marshall-Gradisbik, S., Mena, I., Mikovits, J. A., Miwa, K., Murovska, M., Pall, M. L., and Stevens, S.

Published
2011
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22. The impact of a structured exercise programme upon cognitive function in chronic fatigue syndrome patients

Author

Zalewski, P. (Paweł), Kujawski, S. (Sławomir), Tudorowska, M. (Malwina), Morten, K. (Karl), Tafil-Klawe, M. (Małgorzata), Klawe, J.J. (Jacek J.), Strong, J. (James), Estévez-López, F. (Fernando), Murovska, M. (Modra), Newton, J.L. (Julia L.), Zalewski, P. (Paweł), Kujawski, S. (Sławomir), Tudorowska, M. (Malwina), Morten, K. (Karl), Tafil-Klawe, M. (Małgorzata), Klawe, J.J. (Jacek J.), Strong, J. (James), Estévez-López, F. (Fernando), Murovska, M. (Modra), and Newton, J.L. (Julia L.)

Abstract

Background: Cognitive function disturbance is a frequently described symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, the effects of a structured exercise programme (SEP) upon cognitive function in ME/CFS patients was examined. Methods: Out of the 53 ME/CFS patients initiating SEP 34 (64%) completed the 16 week programme. Cognitive function was assessed using a computerized battery test consisting of a Simple Reaction Time (SRT) (repeated three times) a

Published
2019
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24. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - Evidence for an autoimmune disease

Author

Sotzny, F, Blanco, J, Capelli, E, Castro-Marrero, J, Steiner, S, Murovska, M, and Scheibenbogen, C

Subjects
Chronic Fatigue Syndrome, Biomarker, Myalgic Encephalomyelitis, Autoimmune, Autoantibodies
Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent and severe chronic disease drastically impairing life quality. The underlying pathomechanism is incompletely understood yet but there is convincing evidence that in at least a subset of patients ME/CFS has an autoimmune etiology. In this review, we will discuss current autoimmune aspects for ME/CFS. Immune dysregulation in ME/CFS has been frequently described including changes in cytokine profiles and immunoglobulin levels, T- and B-cell phenotype and a decrease of natural killer cell cytotoxicity. Moreover, autoantibodies against various antigens including neurotransmitter receptors have been recently identified in ME/CFS individuals by several groups. Consistently, clinical trials from Norway have shown that B-cell depletion with rituximab results in clinical benefits in about half of ME/CFS patients. Furthermore, recent studies have provided evidence for severe metabolic disturbances presumably mediated by serum autoantibodies in ME/CFS. Therefore, further efforts are required to delineate the role of autoantibodies in the onset and pathomechanisms of ME/CFS in order to better understand and properly treat this disease. (C) 2018 The Author(s). Published by Elsevier B.V.

Published
2018

26. The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE

Author

Scheibenbogen, C, Freitag, H, Blanco, J, Capelli, E, Lacerda, E, Authier, J, Meeus, M, Marrero, JC, Nora-Krukle, Z, Oltra, E, Strand, EB, Shikova, E, Sekulic, S, and Murovska, M

Subjects
musculoskeletal diseases, European network, Landscape project, B cell, Cytokines, Autoimmunity, Biomarker, Diagnostic, Viral, ME/CFS, Autoantibodies
Abstract

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a common and severe disease with a considerable social and economic impact. So far, the etiology is not known, and neither a diagnostic marker nor licensed treatments are available yet. The EUROMENE network of European researchers and clinicians aims to promote cooperation and advance research on ME/CFS. To improve diagnosis and facilitate the analysis of clinical trials surrogate markers are urgently needed. As a first step for developing such biomarkers for clinical use a database of active biomarker research in Europe was established called the ME/CFS EUROMENE Biomarker Landscape project and the results are presented in this review. Further we suggest strategies to improve biomarker development and encourage researchers to take these into consideration for designing and reporting biomarker studies.

Published
2017

28. Infectious disease research at Riga Stadins University

Author

Isaguliants, M., Barisevs, M., Chapenko, S., Cistjakovs, M., Donina, S., Gravelsina, S., Holodnuka, I., Kadisa, A., Kozireva, S., Logina, I., Nora-Krukle, Z., Sultanova, A., and Murovska, M.

Published
2014

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