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6,733 results on '"Murray, Andrew"'

3. A low-energy MHz repetition rate short-pulse electron gun

Author

Murray, Andrew James and Rogers, Joshua

Subjects
Physics - Instrumentation and Detectors, Physics - Atomic Physics
Abstract

A pulsed electron gun that can produce MHz repetition rate nanosecond pulses is described. The gun uses a Pierce grid in combination with an anode to extract electrons from a tungsten filament cathode. The electrons emerging from the anode are accelerated and focused using two triple-aperture lenses to form a beam. By applying a high speed grid pulse that transitions through the extraction voltage region of the grid/anode combination, pulses of electrons are produced from the gun that have temporal widths less than 5 ns. The pulsed beams are produced at both rising and falling edges of the driving pulse. The characteristics of the emerging electron beams have been determined using an (e,2e) coincidence spectrometer and examples where they are used for time of flight decay measurements are given., Comment: 10 pages, 7 figures

Published
2024

4. Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders

Author

Lawrence, Elijah S, Gu, Wanjun, Bohlender, Ryan J, Anza-Ramirez, Cecilia, Cole, Amy M, Yu, James J, Hu, Hao, Heinrich, Erica C, O’Brien, Katie A, Vasquez, Carlos A, Cowan, Quinn T, Bruck, Patrick T, Mercader, Kysha, Alotaibi, Mona, Long, Tao, Hall, James E, Moya, Esteban A, Bauk, Marco A, Reeves, Jennifer J, Kong, Mitchell C, Salem, Rany M, Vizcardo-Galindo, Gustavo, Macarlupu, Jose-Luis, Figueroa-Mujíca, Rómulo, Bermudez, Daniela, Corante, Noemi, Gaio, Eduardo, Fox, Keolu P, Salomaa, Veikko, Havulinna, Aki S, Murray, Andrew J, Malhotra, Atul, Powel, Frank L, Jain, Mohit, Komor, Alexis C, Cavalleri, Gianpiero L, Huff, Chad D, Villafuerte, Francisco C, and Simonson, Tatum S

Subjects
Biological Sciences, Genetics, 2.1 Biological and endogenous factors, Generic health relevance, Humans, Adaptation, Physiological, Altitude, East Asian People, Hematocrit, Hypoxia, Mutation, Missense, South American People
Abstract

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration in Tibetans. We provide evidence for an association between an adaptive EPAS1 variant (rs570553380) and the same phenotype of relatively low hematocrit in Andean highlanders. This Andean-specific missense variant is present at a modest frequency in Andeans and absent in other human populations and vertebrate species except the coelacanth. CRISPR-base-edited human cells with this variant exhibit shifts in hypoxia-regulated gene expression, while metabolomic analyses reveal both genotype and phenotype associations and validation in a lowland population. Although this genocopy of relatively lower hematocrit in Andean highlanders parallels well-replicated findings in Tibetans, it likely involves distinct pathway responses based on a protein-coding versus noncoding variants, respectively. These findings illuminate how unique variants at EPAS1 contribute to the same phenotype in Tibetans and a subset of Andean highlanders despite distinct evolutionary trajectories.

Published
2024

6. The Spirit of Christ

Author

Murray, Andrew

Subjects
The Spirit of Christ (Nonfiction work), Literature/writing
Abstract

LibriVox recording of The Spirit of Christ by Andrew Murray. Read in English by Christopher Smith. Shortly after his ascension to heaven, Jesus sent the Holy Spirit, the Promise of [...]

Published
2024

7. Limited oxygen in standard cell culture alters metabolism and function of differentiated cells

Author

Tan, Joycelyn, Virtue, Sam, Norris, Dougall M, Conway, Olivia J, Yang, Ming, Bidault, Guillaume, Gribben, Christopher, Lugtu, Fatima, Kamzolas, Ioannis, Krycer, James R, Mills, Richard J, Liang, Lu, Pereira, Conceição, Dale, Martin, Shun-Shion, Amber S, Baird, Harry JM, Horscroft, James A, Sowton, Alice P, Ma, Marcella, Carobbio, Stefania, Petsalaki, Evangelia, Murray, Andrew J, Gershlick, David C, Nathan, James A, Hudson, James E, Vallier, Ludovic, Fisher-Wellman, Kelsey H, Frezza, Christian, Vidal-Puig, Antonio, and Fazakerley, Daniel J

Published
2024
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9. Measurements of the Kr (e, 2e) differential cross section in the perpendicular plane, from 2 eV to 120 eV above the ionization threshold

Author

Murray, Andrew James and Rogers, Joshua

Subjects
Physics - Atomic Physics
Abstract

New (e, 2e) differential cross section measurements from krypton are presented in the perpendicular plane, where the incident electron beam is orthogonal to the scattered and ejected electrons that map out a detection plane. New data were obtained at incident energies from 30 eV to 120 eV above the ionization potential (IP), the experiment being configured to detect scattered and ejected electrons with equal energy. The results are compared to previous measurements from 2 eV to 50 eV above the IP and to calculations from different models in this energy range. The new experiments confirm the results from previous measurements. The results are also compared to recent data for argon acquired under the same kinematic conditions, to highlight similarities and differences that are observed.

Published
2023
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10. Author Correction: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells

Author

Tan, Joycelyn, Virtue, Sam, Norris, Dougall M, Conway, Olivia J, Yang, Ming, Bidault, Guillaume, Gribben, Christopher, Lugtu, Fatima, Kamzolas, Ioannis, Krycer, James R, Mills, Richard J, Liang, Lu, Pereira, Conceição, Dale, Martin, Shun-Shion, Amber S, Baird, Harry JM, Horscroft, James A, Sowton, Alice P, Ma, Marcella, Carobbio, Stefania, Petsalaki, Evangelia, Murray, Andrew J, Gershlick, David C, Nathan, James A, Hudson, James E, Vallier, Ludovic, Fisher-Wellman, Kelsey H, Frezza, Christian, Vidal-Puig, Antonio, and Fazakerley, Daniel J

Published
2024
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12. Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

Author

Verma, Nirmal, Velmurugan, Gopal Viswanathan, Winford, Edric, Coburn, Han, Kotiya, Deepak, Leibold, Noah, Radulescu, Laura, Despa, Sanda, Chen, Kuey C, Van Eldik, Linda J, Nelson, Peter T, Wilcock, Donna M, Jicha, Gregory A, Stowe, Ann M, Goldstein, Larry B, Powel, David K, Walton, Jeffrey H, Navedo, Manuel F, Nystoriak, Matthew A, Murray, Andrew J, Biessels, Geert Jan, Troakes, Claire, Zetterberg, Henrik, Hardy, John, Lashley, Tammaryn, and Despa, Florin

Subjects
Biochemistry and Cell Biology, Biological Sciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Acquired Cognitive Impairment, Alzheimer's Disease, Neurosciences, Brain Disorders, Dementia, Aging, Aetiology, 2.1 Biological and endogenous factors, Neurological, Humans, Rats, Animals, Islet Amyloid Polypeptide, Alzheimer Disease, Amyloid beta-Peptides, Amyloidogenic Proteins, Pancreas, Inflammation, Biological sciences, Biomedical and clinical sciences
Abstract

Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we show in human tissues and AD-model rats that bloodborne islet amyloid polypeptide (amylin) secreted from the pancreas perturbs cerebral Aβ clearance. Blood amylin concentrations are higher in AD than in cognitively unaffected persons. Amyloid-forming amylin accumulates in circulating monocytes and co-deposits with Aβ within the brain microvasculature, possibly involving inflammation. In rats, pancreatic expression of amyloid-forming human amylin indeed induces cerebrovascular inflammation and amylin-Aβ co-deposits. LRP1-mediated Aβ transport across the blood-brain barrier and Aβ clearance through interstitial fluid drainage along vascular walls are impaired, as indicated by Aβ deposition in perivascular spaces. At the molecular level, cerebrovascular amylin deposits alter immune and hypoxia-related brain gene expression. These converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology.

Published
2023

13. A low-cost and reliable laser shutter interlock using a software-command interface

Author

Rogers, Joshua P and Murray, Andrew J

Subjects
Physics - Instrumentation and Detectors
Abstract

A simple and low-cost laser interlock is presented that operates via software commands issued by an ESP32 microcontroller. The architecture of the device is constructed to ensure the laser output is shut off in the event of either an open circuit on the interlock signal line from the laser enclosure or loss of power to the device. Unintentional exposure to the laser beam is prevented by overruling local controls (such as a keypad), until both the enclosure is re-interlocked and the user actively intervenes. The device presented is designed to close the mechanical shutter of a Spectra-Physics Millennia Pro pump laser while it continues to operate internally. The hardware and coding are versatile enough to be deployed on any instrument that receives software commands via a serial interface., Comment: 4 pages, 3 figures

Published
2022
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18. LASED: A Laser-Atom Interaction Simulator derived from Quantum Electrodynamics

Author

Patel, Manish, Harvey, Matthew, and Murray, Andrew James

Subjects
Physics - Atomic Physics, Physics - Computational Physics, Quantum Physics
Abstract

A laser-atom interaction simulator derived from quantum electrodynamics (LASED) is presented, which has been developed in the python programming language. LASED allows a user to calculate the time evolution of a laser-excited atomic system. The model allows for any laser polarization, a Gaussian laser beam profile, a rotation of the reference frame chosen to define the states, and an averaging over the Doppler profile of an atomic beam. Examples of simulations using LASED are presented for excitation of calcium from the 4$^1S_0$ state to the 4$^1P_1$ state, for excitation from the helium 3$^1D_2$ state excited by electron impact to the 10$^1P_1$ state, and for laser excitation of caesium via the $D_2$ line., Comment: 15 pages, 8 figures, for source code go to https://github.com/mvpmanish/LASED. Changes in v3: changed title, added more references, changed comparison of this simulator to other laser-atom simulators, corrected formatting errors, added to Fig.6, added appendix C. Changes in v4: corrected Eq. 24

Published
2022
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30. Programming of cardiac metabolism by miR-15b-5p, a miRNA released in cardiac extracellular vesicles following ischemia-reperfusion injury

Author

Pantaleão, Lucas C., Loche, Elena, Fernandez-Twinn, Denise S., Dearden, Laura, Córdova-Casanova, Adriana, Osmond, Clive, Salonen, Minna K., Kajantie, Eero, Niu, Youguo, de Almeida-Faria, Juliana, Thackray, Benjamin D., Mikkola, Tuija M., Giussani, Dino A., Murray, Andrew J., Bushell, Martin, Eriksson, Johan G., and Ozanne, Susan E.

Published
2024
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33. PERSUADE Survey—PERioperative AnestheSia and Intensive Care Management of Left VentricUlar Assist DevicE Implantation in Europe and the United States

Author

Alfirevic, Andrej, Anton, James M., Antoniou, Theofani, Auci, Elisabetta, Badakhsh, Orode, Banks, Dalia A., Barrio, Jose M., Bartels, Karsten, Belli, Erol V., Bermede, Onat, Bettex, Dominique, Biedermann, Sébastien, Boelsen, Jonas, Boisen, Michael L., Book, Malte, Bottiger, Brandi A., Bouchez, Stefaan, Bräuer, Anselm, Brodt, Jessica L, Chaudhry, Sunit-Preet, Conlin, Frederick T., Cormican, Daniel S., Cristinar, Mircea, Curtis, Michael S., Dalia, Adam A., D'Avino, Emilio, Durand, Michel, Eberle, Balthasar, Emmert, Daniel A., Erb, Joachim M., Falterman, Jason, Forner, Anna Flo, Gatha, Nehal M., Gaudard, Philippe, Giebler, Antasia, Gliga, Louise A., Guarracino, Fabio, Gürcü, Mustafa E., Hans, Gregory A., Hanson, Ross S., Heringlake, Matthias, Hilberath, Jan N., Hommel, Matthias, Huhn, Ragnar, Iyer, Manoj H., Jacquet, Luc M., Karadeniz, Ümit, Kertai, Miklos D., Martin, Archer Kilbourne, Kolarczyk, Lavinia M., Koller, Tobias, Kurian, Dinesh J., Kornfield, Zev N., Koster, Andreas, Kranke, Peter, Krauss, Bernadette, Kudsioglu, Turkan, Kwak, Jenny, Lachauer, Steffen, Lagier, David, Lango, Romuald, Liang, Hong, Lilie, Craig J., Logeman, Elisabeth Angelique, Magunia, Harry, Mahmoud, Saifeldin, Makar, Moody, Markovic, Dejan, Mathis, Michael R., Mattei, Mathieu, Mazzeffi, Michael A., McCabe, Melissa D., Meers, J. Brad, Moitra, Vivek K., Møller-Sørensen, Hasse, Moravcova, Sarka, Muellejans, Bernd, Münch, Christopher M., Murray, Andrew W., Moncho, Azucena Pajares, Ngai, Jennie, Nielsen, Dorthe V., Ortoleva, Jamel P., Ouattara, Alexandre, Patel, Bhoumesh, Paul, Frank, Peng, Yong G., Pittarello, Demetrio, Prabhu, Mahesh, Rancati, Valentina, Rex, Steffen, Riha, Hynek, Robitaille, Mark J., Blanco, Yiliam Rodriguez, Rovira, Irene, Ruusalepp, Arno, Samalavicius, Robertas, Saatee, Siavosh, Sauer, William J., Scheiermann, Patrick, Schlesinger, Rachel E., Schroeder, Andrew M., Schroeder, Sarah E., Shih, Henry, Slaughter, Mark S., Sostaric, Maja, Šribar, Andrej, Svalebjørg, Morten, Székely, Andrea, Szentgyorgyi, Lajos, ter Horst, Maarten, Tschernko, Edda M., Twite, Mark, Ulrichs, Christoph, van der Maaten, Joost M.A.A., van der Ploeg, Nathalie, Vilela, Hugo P., von Homeyer, Peter, Wagner, Nana-Maria, Weiner, Menachem M., Wunder, Christian, Zink, Wolfgang, Kummerow, Maren, von Dossow, Vera, Pasero, Daniela, Martinez Lopez de Arroyabe, Blanca, Abrams, Benjamin, Kowalsky, Markus, Wilkey, Barbara J., Subramanian, Kathirvel, Martin, Archer K., Marczin, Nandor, and de Waal, Eric E.C.

Published
2024
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35. Physical Demands of Tennis Across the Different Court Surfaces, Performance Levels and Sexes: A Systematic Review with Meta-analysis

Author

Pluim, Babette M., Jansen, Marleen G. T., Williamson, Samuel, Berry, Cain, Camporesi, Silvia, Fagher, Kristina, Heron, Neil, van Rensburg, Dina C. Janse, Moreno-Pérez, Víctor, Murray, Andrew, O’Connor, Seán R., de Oliveira, Fábio C. L., Reid, Machar, van Reijen, Miriam, Saueressig, Tobias, Schoonmade, Linda J., Thornton, Jane S., Webborn, Nick, and Ardern, Clare L.

Published
2023
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40. Learn About Direct Compensation Property Damage Coverage

Author

Murray, Andrew

Subjects
Property and casualty insurance -- Laws, regulations and rules, Government regulation, Business, international
Abstract

I've been helping clients involved in car crashes for 30 years now, which means I've seen 30 years of changes with auto insurance, usually with a negative impact for the [...]

Published
2024

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