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539 results on '"Murray, David L."'

1. Correction: Value of bone marrow examination in determining response to therapy in patients with multiple myeloma in the context of mass spectrometry-based M-protein assessment

Author

Claveau, Jean-Sébastien, Murray, David L., Dispenzieri, Angela, Kapoor, Prashant, Binder, Moritz, Buadi, Francis, Dingli, David, Fonder, Amie, Gertz, Morie, Gonsalves, Wilson, Hayman, Suzanne, Hobbs, Miriam, Hwa, Yi Lisa, Kourelis, Taxiarchis, Lacy, Martha, Leung, Nelson, Lin, Yi, Warsame, Rahma, Kyle, Robert A., Rajkumar, Vincent, and Kumar, Shaji K.

Published
2024
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2. Value of bone marrow examination in determining response to therapy in patients with multiple myeloma in the context of mass spectrometry-based M-protein assessment

Author

Claveau, Jean-Sébastien, Murray, David L., Dispenzieri, Angela, Kapoor, Prashant, Binder, Moritz, Buadi, Francis, Dingli, David, Fonder, Amie, Gertz, Morie, Gonsalves, Wilson, Hayman, Suzanne, Hobbs, Miriam, Hwa, Yi Lisa, Kourelis, Taxiarchis, Lacy, Martha, Leung, Nelson, Lin, Yi, Warsame, Rahma, Kyle, Robert A., Rajkumar, Vincent, and Kumar, Shaji K.

Published
2023
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3. Mass spectrometry–based assessment of prostate cancer–associated crystalloids reveals enrichment for growth and differentiation factor 15

Author

Tekin, Burak, Dasari, Surendra, Theis, Jason D., Vrana, Julie A., Murray, David L., Oglesbee, Devin, Thompson, R. Houston, Leibovich, Bradley C., Boorjian, Stephen A., Whaley, Rumeal D., Hernandez, Loren Herrera, Jimenez, Rafael E., Cheville, John C., Karnes, R. Jeffrey, Sukov, William R., and Gupta, Sounak

Published
2023
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6. Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies: Guideline From the College of American Pathologists in Collaboration With the American Association for Clinical Chemistry and the American Society for Clinical Pathology

Author

Keren, David F., Bocsi, Gregary, Billman, Brooke L., Etzell, Joan, Faix, James D., Kumar, Shaji, Lipe, Brea, McCudden, Christopher, Montgomery, Roberta, Murray, David L., Rai, Alex J., Redondo, Teresita Cuyegkeng, Souter, Lesley, Ventura, Christina B., and Ansari, Mohammad Qasim

Subjects
Practice guidelines (Medicine), Monoclonal gammopathies -- Diagnosis, Evidence-based medicine, Diagnosis, Laboratory -- Methods -- Standards, Health, American Association for Clinical Chemistry -- Standards, College of American Pathologists -- Standards
Abstract

Context.--The process for identifying patients with monoclonal gammopathies is complex. Initial detection of a monoclonal immunoglobulin protein (M protein) in the serum or urine often requires compilation of analytical data from several areas of the laboratory. The detection of M proteins depends on adequacy of the sample provided, available clinical information, and the laboratory tests used. Objective.--To develop an evidence-based guideline for the initial laboratory detection of M proteins. Design.--To develop evidence-based recommendations, the College of American Pathologists convened a panel of experts in the diagnosis and treatment of monoclonal gammopathies and the laboratory procedures used for the initial detection of M proteins. The panel conducted a systematic literature review to address key questions. Using the Grading of Recommendations Assessment, Development, and Evaluation approach, recommendations were created based on the available evidence, strength of that evidence, and key judgements as defined in the Grading of Recommendations Assessment, Development, and Evaluation Evidence to Decision framework. Results.--Nine guideline statements were established to optimize sample selection and testing for the initial detection and quantitative measurement of M proteins used to diagnose monoclonal gammopathies. Conclusions.--This guideline was constructed to harmonize and strengthen the initial detection of an M protein in patients displaying symptoms or laboratory features of a monoclonal gammopathy. It endorses more comprehensive initial testing when there is suspicion of amyloid light chain amyloidosis or neuropathies, such as POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome, associated with an M protein. (Arch Pathol Lab Med. 2022;146:575-590; doi: 10.5858/arpa.2020-0794-CP), Monoclonal gammopathies (MGs) represent a spectrum of disorders with varying manifestations ranging from a completely asymptomatic condition picked up on laboratory testing to a catastrophic, life-threatening presentation in the clinic. [...]

Published
2022
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13. Kidney Transplantation in Patients With Monoclonal Gammopathy of Renal Significance (MGRS)–Associated Lesions: A Case Series

Author

Heybeli, Cihan, Alexander, Mariam Priya, Bentall, Andrew J., Amer, Hatem, Buadi, Francis K., Dean, Patrick G., Dingli, David, Dispenzieri, Angela, El Ters, Mireille, Gertz, Morie A., Issa, Naim S., Kapoor, Prashant, Kourelis, Taxiarchis, Kukla, Aleksandra, Kumar, Shaji, Lacy, Martha Q., Lorenz, Elizabeth C., Muchtar, Eli, Murray, David L., Nasr, Samih H., Prieto, Mikel, Rajkumar, S. Vincent, Schinstock, Carrie A., Stegall, Mark D., Warsame, Rahma, and Leung, Nelson

Published
2022
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21. Treatment of AL Amyloidosis: Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Statement 2020 Update

Author

Muchtar, Eli, Dispenzieri, Angela, Gertz, Morie A., Kumar, Shaji K., Buadi, Francis K., Leung, Nelson, Lacy, Martha Q., Dingli, David, Ailawadhi, Sikander, Bergsagel, P. Leif, Fonseca, Rafael, Hayman, Suzanne R., Kapoor, Prashant, Grogan, Martha, Abou Ezzeddine, Omar F., Rosenthal, Julie L., Mauermann, Michelle, Siddiqui, Mustaqueem, Gonsalves, Wilson I., Kourelis, Taxiarchis V., Larsen, Jeremy T., Reeder, Craig B., Warsame, Rahma, Go, Ronald S., Murray, David L., McPhail, Ellen D., Dasari, Surendra, Jevremovic, Dragan, Kyle, Robert A., Lin, Yi, Lust, John A., Russell, Stephen J., Hwa, Yi Lisa, Fonder, Amie L., Hobbs, Miriam A., Rajkumar, S. Vincent, Roy, Vivek, and Sher, Taimur

Published
2021
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24. A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis

Author

Heybeli, Cihan, Bentall, Andrew, Wen, Jiqiu, Alexander, Mariam Priya, Buadi, Francis K., Cosio, Fernando G., Dean, Patrick G., Dispenzieri, Angela, Dingli, David, El Ters, Mireille, Gertz, Morie A., Amer, Hatem, Kapoor, Prashant, Khamash, Hasan, Kourelis, Taxiarchis, Kumar, Shaji, Lorenz, Elizabeth C., Mai, Martin, Muchtar, Eli, Murray, David L., Prieto, Mikel, Schinstock, Carrie A., Stegall, Mark D., Warsame, Rahma, and Leung, Nelson

Published
2021
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27. Revisiting complete response in light chain amyloidosis

Author

Sidana, Surbhi, Dispenzieri, Angela, Murray, David L., Go, Ronald S., Buadi, Francis K., Lacy, Martha Q., Gonsalves, Wilson I., Dingli, David, Warsame, Rahma, Kourelis, Taxiarchis, Muchtar, Eli, Hayman, Suzanne R., Kapoor, Prashant, Kyle, Robert A., Leung, Nelson, Rajkumar, S. Vincent, Gertz, Morie A., and Kumar, Shaji K.

Published
2020
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28. IgM AL amyloidosis: delineating disease biology and outcomes with clinical, genomic and bone marrow morphological features

Author

Sidana, Surbhi, Larson, Daniel P., Greipp, Patricia T., He, Rong, McPhail, Ellen D., Dispenzieri, Angela, Murray, David L., Dasari, Surendra, Ansell, Stephen M., Muchtar, Eli, Gonsalves, Wilson I., Kourelis, Taxiarchis V., Ramirez-Alvarado, Marina, Kapoor, Prashant, Rajkumar, S. Vincent, Lacy, Martha Q., Buadi, Francis K., Leung, Nelson, Kyle, Robert A., Kumar, Shaji K., King, Rebecca L., and Gertz, Morie A.

Published
2020
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29. Clinical specificity of two assays for immunoglobulin kappa and lambda free light chains.

Author

Farnsworth, Christopher W., Roemmich, Brittany, Spears, Grant M., Murray, David L., Dispenzieri, Angela, and Willrich, Maria Alice V.

Subjects
IMMUNOGLOBULIN light chains, PLASMA cell diseases, BLOOD protein electrophoresis, MONOCLONAL antibodies, GLOMERULAR filtration rate, SYMPTOMS, ERYTHROPOIETIN receptors
Abstract

Free light chain (FLC) assays and the ratio of κ/λ are recommended for diagnosis, prognosis and monitoring of plasma cell dyscrasias (PCD). Limited data exists on FLC clinical specificity in patients diagnosed with other conditions. We assessed the κ, λ, and κ/λ FLC ratio using the FreeLite assay and the Sebia FLC ELISA assay in 176 patients with clinical presentations of fatigue, anemia, polyclonal hypergammaglobulinemia, joint disorders, kidney disease and non PCD-cancers with no monoclonal protein observed on serum protein electrophoresis or MASS-FIX immunoglobulin isotyping. Manufacturer defined reference intervals (RI) and glomerular filtration rate (GFR) specific RI (renal RI) were utilized. For the κ/λ ratio, 68.7 % (121/176) of specimens on the FreeLite and 87.5 % (154/176) of specimens on the Sebia assay were within RI. For κ, 68.2 % (120/176) and 72.2 % (127/176) of results were outside RI for FreeLite and Sebia respectively. For λ, 37.5 % (66/176) and 84.1 % (148/176) of FreeLite and Sebia results were outside RI. With FreeLite and Sebia, patients with kidney disease (n=25) had the highest κ/λ ratios. 44 patients (25.0 %) had GFR <60 mL/min/BSA. When renal RI were applied, 13.6 % had a FLCr outside the renal RI with FreeLite, and 4.5 % with Sebia. In a cohort of patients with signs and symptoms suggestive of PCDs, but ultimately diagnosed with other conditions, Sebia FLC had improved clinical specificity relative to FreeLite, if one was using an abnormal κ/λ ratio as a surrogate for monoclonality. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Correction: MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients

Author

Mellors, Patrick W., Dasari, Surendra, Kohlhagen, Mindy C., Kourelis, Taxiarchis, Go, Ronald S., Muchtar, Eli, Gertz, Morie A., Kumar, Shaji K., Buadi, Francis. K., Willrich, Maria A. V., Lust, John A., Kapoor, Prashant, Lacy, Martha Q., Dingli, David, Hwa, Yi, Fonder, Amie, Hobbs, Miriam, Hayman, Susan, Warsame, Rahma, Leung, Nelson R., Lin, Yi, Gonsalves, Wilson, Siddiqui, Mustaqeem, Kyle, Robert A., Rajkumar, S. Vincent, Murray, David L., and Dispenzieri, Angela

Published
2021
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35. MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients

Author

Mellors, Patrick W., Dasari, Surendra, Kohlhagen, Mindy C., Kourelis, Taxiarchis, Go, Ronald S., Muchtar, Eli, Gertz, Morie A., Kumar, Shaji K., Buadi, Francis. K., Willrich, Maria A. V., Lust, John A., Kapoor, Prashant, Lacy, Martha Q., Dingli, David, Hwa, Yi, Fonder, Amie, Hobbs, Miriam, Hayman, Susan, Warsame, Rahma, Leung, Nelson R., Lin, Yi, Gonsalves, Wilson, Siddiqui, Mustaqeem, Kyle, Robert A., Rajkumar, S. Vincent, Murray, David L., and Dispenzieri, Angela

Published
2021
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40. Screening and Diagnosis of Monoclonal Gammopathies: An International Survey of Laboratory Practice

Author

Genzen, Jonathan R., Murray, David L., Abel, Gyorgy, Meng, Qing H., Baltaro, Richard J., Rhoads, Daniel D., Delgado, Julio C., Souers, Rhona J., Bashleben, Christine, Keren, David F., and Ansari, Mohammad Q.

Subjects
Immunoglobulins -- Physiological aspects -- Genetic aspects -- Research, Hematologic diseases -- Genetic aspects -- Diagnosis -- Care and treatment -- Research, Health
Abstract

Context.--Serum tests used for the screening and diagnosis of monoclonal gammopathies include serum protein electrophoresis (SPE; agarose gel or capillary zone), immunofixation (IFE) and immunosubtraction capillary electrophoresis, serum free light chains, quantitative immunoglobulins, and heavy/light-chain combinations. Urine protein electrophoresis and urine IFE may also be used to identify Bence-Jones proteinuria. Objective.--To assess current laboratory practice for monoclonal gammopathy testing. Design.--In April 2016, a voluntary questionnaire was distributed to 923 laboratories participating in a protein electrophoresis proficiency testing survey. Results.--Seven hundred seventy-four laboratories from 38 countries and regions completed the questionnaire (83.9% response rate; 774 of 923). The majority of participants (68.6%; 520 of 758) used agarose gel electrophoresis as their SPE method, whereas 31.4% (238 of 758) used capillary zone electrophoresis. The most common test approaches used in screening were SPE with reflex to IFE/immunosubtraction capillary electrophoresis (39.3%; 299 of 760); SPE only (19.1%; 145 of 760); SPE and IFE or immunosubtraction capillary electrophoresis (13.9%; 106 of 760); and SPE with IFE, serum free light chain, and quantitative immunoglobulins (11.8%; 90 of 760). Only 39.8% (305 of 767) of laboratories offered panel testing for ordering convenience. Although SPE was used by most laboratories in diagnosing new cases of myeloma, when laboratories reported the primary test used to follow patients with monoclonal gammopathy, only 55.7% (403 of 724) chose SPE, with the next most common selections being IFE (18.9%; 137 of 724), serum free light chain (11.7%; 85 of 724), and immunosubtraction capillary electrophoresis (2.1%; 15 of 724). Conclusions.--Ordering and testing practices for the screening and diagnosis of monoclonal gammopathy vary widely across laboratories. Improving utilization management and report content, as well as recognition and development of laboratory-directed testing guidelines, may serve to enhance the clinical value of testing. doi: 10.5858/arpa.2017-0128-CP, Monoclonal gammopathies are hematologic disorders characterized by abnormal production of one or more immunoglobulin clones. (1) They range from asymptomatic, benign disorders (such as monoclonal gammopathy of undetermined significance) to [...]

Published
2018
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42. Kappa Free Light Chain Drift Prompts the Need for a New Upper Limit of Normal Free Light Chain Ratio to Avoid an Epidemic of Kappa Light Chain Monoclonal Gammopathy of Undermined Significance

Author

Rozenova, Krasimira, primary, Willrich, Maria, additional, Snyder, Melissa, additional, Dasari, Surendra, additional, Kourelis, Taxiarchis, additional, Rajkumar, S Vincent, additional, Kumar, Shaji, additional, Dispenzieri, Angela, additional, and Murray, David L, additional

Published
2023
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44. Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group

Author

Go, Ronald S., Winters, Jeffrey L., Leung, Nelson, Murray, David L., Willrich, Maria A., Abraham, Roshini S., Amer, Hatem, Hogan, William J., Marshall, Ariela L., Sethi, Sanjeev, Tran, Cheryl L., Chen, Dong, Pruthi, Rajiv K., Ashrani, Aneel A., Fervenza, Fernando C., Cramer, Carl H., II, Hook, C. Christopher, Garovic, Vesna D., Yui, Jennifer C., Botero, Juliana Perez, Rodriguez, Vilmarie, Wolanskyj, Alexandra P., and Thomé, Stephan D.

Published
2016
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46. Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Author

Clay-Gilmour, Alyssa I., Rishi, Abdul R., Goldin, Lynn R., Greenberg-Worisek, Alexandra J., Achenbach, Sara J., Rabe, Kari G., Maurer, Matthew J., Kay, Neil E., Shanafelt, Tait D., Call, Timothy G., Brice Weinberg, J., Camp, Nicola J., Cerhan, James R., Leis, Jose, Norman, Aaron, Murray, David L., Vincent Rajkumar, S., Caporaso, Neil E., Landgren, Ola, McMaster, Mary L., Slager, Susan L., and Vachon, Celine M.

Published
2019
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48. Mass Spectrometry-Based Assessment of Prostate Cancer-Associated Crystalloids Reveals Enrichment for Growth & Differentiation Factor 15 (GDF15)

Author

Tekin, Burak, primary, Dasari, Surendra, additional, Theis, Jason D., additional, Vrana, Julie A., additional, Murray, David L., additional, Oglesbee, Devin, additional, Thompson, R. Houston, additional, Leibovich, Bradley C., additional, Boorjian, Stephen A., additional, Whaley, Rumeal D., additional, Hernandez, Loren Herrera, additional, Jimenez, Rafael E., additional, Cheville, John C., additional, Karnes, R. Jeffrey, additional, Sukov, William R., additional, and Gupta, Sounak, additional

Published
2023
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