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5. Complete genome of Escherichia colisequence type 73 with acquired blaTEM-1and high genotypic virulence load identified in human saliva

Author

McDonagh, Francesca, Tumeo, Anna, Murray, Elaine K., Hallahan, Brian, and Miliotis, Georgios

Abstract

Escherichia colisequence type (ST) 73 is a pandemic lineage of the ExPEC (Extraintestinal Pathogenic E. coli) family associated with conserved virulence. We report the complete genome of a genomically hypervirulent E. coliST73 strain isolated from the oral cavity of a patient with a diagnosis of treatment resistant schizophrenia and receiving clozapine treatment.

Published
2024
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6. Precision medicine to manage chronic immune-related conditions

Author

Gibson, David S., primary, Egan, Phil, additional, Guo, Guangran, additional, Kelly, Catriona, additional, McClean, Paula, additional, McGilligan, Victoria, additional, McAllister, Roisin, additional, Matchett, Kyle B., additional, Martin, Chloe A., additional, Murray, Elaine K., additional, Lapsley, Coral R., additional, Rai, Taranjit Singh, additional, and Bjourson, Anthony J., additional

Published
2022
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7. Contributors

Author

Abdoli, Amir, primary, Andersen, Catherine J., additional, Badirzadeh, Alireza, additional, Banday, Aaqib Zaffar, additional, Barbosa, Arsénio, additional, Barnie, Prince Amoah, additional, Baron, Byron, additional, Bellengier, Cécilia, additional, Bjourson, Anthony J., additional, Bogdanos, Dimitrios P., additional, Borges, Tiago, additional, Dardiotis, Efthymios, additional, Duez, Hélène, additional, Egan, Phil, additional, Falak, Reza, additional, Farrugia, Mark, additional, Gibson, David S., additional, Greco, Julia M., additional, Guo, Guangran, additional, Habibi-Anbouhi, Mahdi, additional, Hajizadeh-Saffar, Ensiyeh, additional, Huard, Bertrand, additional, Izadi, Zhila, additional, Jahangir, Shahrbanoo, additional, Jindal, Ankur Kumar, additional, Kelly, Catriona, additional, Lapsley, Coral R., additional, Lin, Xia, additional, Martin, Chloe A., additional, Martins, Luísa Sales, additional, Matchett, Kyle B., additional, Mavropoulos, Athanasios, additional, McAllister, Roisin, additional, McClean, Paula, additional, McGilligan, Victoria, additional, Meamar, Ahmadreza, additional, Mirjalili, Seyedeh Zohreh, additional, Mojtabavi, Nazanin, additional, Murray, Elaine K., additional, de Oliveira, Gislane Lelis Vilela, additional, Pourcet, Benoit, additional, Pradhan, Madhulika, additional, Rai, Taranjit Singh, additional, Ramos, Stephan, additional, Rezaei, Nima, additional, Rodrigues, Guilherme Siqueira Pardo, additional, Russ, Holger A., additional, Sabourian, Reyhaneh, additional, Sakkas, Lazaros I., additional, de Salis, Larissa Vedovato Vilela, additional, Silva, Sérgio, additional, Singh, Deependra, additional, Singh, Manju Rawat, additional, Sitar, Mustafa Erinç, additional, Sturm, Nathalie, additional, Tobón, Gabriel J., additional, Tyagi, Rahul, additional, Vivas, Álvaro J., additional, Yadav, Krishna, additional, Yazdanpanah, Niloufar, additional, Zafiriou, Efterpi, additional, Zeydabadinejad, Sareh, additional, and Zhaoliang, Su, additional

Published
2022
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8. Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients.

Author

McLarnon, Thomas, McDaid, Darren, Lynch, Seodhna M., Cooper, Eamonn, McLaughlin, Joseph, McGilligan, Victoria E., Watterson, Steven, Shukla, Priyank, Zhang, Shu-Dong, Bucholc, Magda, English, Andrew, Peace, Aaron, O'Kane, Maurice, Kelly, Martin, Bhavsar, Manav, Murray, Elaine K., Gibson, David S., Walsh, Colum P., Bjourson, Anthony J., and Rai, Taranjit Singh

Subjects
MACHINE learning, SARS-CoV-2, SUPPORT vector machines, COVID-19 pandemic, BLOOD proteins, COVID-19
Abstract

Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vital for COVID-19 research. Methods: We investigated the proteomic and genomic profile of COVID-19-positive patients (n = 400 for proteomics, n = 483 for genomics), focusing on differential regulation between hospitalised and non-hospitalised COVID-19 patients. Signatures had their predictive capabilities tested using independent machine learning models such as Support Vector Machine (SVM), Random Forest (RF) and Logistic Regression (LR). Results: This study has identified 224 differentially expressed proteins involved in various inflammatory and immunological pathways in hospitalised COVID-19 patients compared to non-hospitalised COVID-19 patients. LGALS9 (p-value < 0.001), LAMP3 (p-value < 0.001), PRSS8 (p-value < 0.001) and AGRN (p-value < 0.001) were identified as the most statistically significant proteins. Several hundred rsIDs were queried across the top 10 significant signatures, identifying three significant SNPs on the FSTL3 gene showing a correlation with hospitalisation status. Conclusions: Our study has not only identified key signatures of COVID-19 patients with worsened health but has also demonstrated their predictive capabilities as potential biomarkers, which suggests a staple role in the worsened health effects caused by COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Genomic, Proteomic and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study (Preprint)

Author

English, Andrew, primary, McDaid, Darren, additional, Lynch, Seodhna M, additional, McLaughlin, Joseph, additional, Cooper, Eamonn, additional, Wingfield, Benjamin, additional, Kelly, Martin, additional, Bhavsar, Manav, additional, McGilligan, Victoria, additional, Irwin, Rachelle E, additional, Bucholc, Magda, additional, Zhang, Shu-Dong, additional, Shukla, Priyank, additional, Rai, Taranjit Singh, additional, Bjourson, Anthony J, additional, Murray, Elaine, additional, Gibson, David S, additional, and Walsh, Colum, additional

Published
2024
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10. Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study

Author

English, Andrew, McDaid, Darren, Lynch, Seodhna M., McLaughlin, Joseph, Cooper, Eamonn, Wingfield, Benjamin, Kelly, Martin, Bhavsar, Manav, McGilligan, Victoria, Irwin, Rachelle E., Bucholc, Magda, Zhang, Shu-Dong, Shukla, Priyank, Rai, Taranjit Singh, Bjourson, Anthon J., Murray, Elaine, Gibson, David S., Walsh, Colum, English, Andrew, McDaid, Darren, Lynch, Seodhna M., McLaughlin, Joseph, Cooper, Eamonn, Wingfield, Benjamin, Kelly, Martin, Bhavsar, Manav, McGilligan, Victoria, Irwin, Rachelle E., Bucholc, Magda, Zhang, Shu-Dong, Shukla, Priyank, Rai, Taranjit Singh, Bjourson, Anthon J., Murray, Elaine, Gibson, David S., and Walsh, Colum

Abstract

Background: Health organizations and countries around the world have found it difficult to control the spread of COVID-19. To minimize the future impact on the UK National Health Service and improve patient care, there is a pressing need to identify individuals who are at a higher risk of being hospitalized because of severe COVID-19. Early targeted work was successful in identifying angiotensin-converting enzyme -2 receptors and type II transmembrane serine protease dependency as drivers of severe infection. Although a targeted approach highlights key pathways, a multiomics approach will provide a clearer and more comprehensive picture of severe COVID-19 etiology and progression. Objective: The COVID-19 Response Study aims to carry out an integrated multiomics analysis to identify biomarkers in blood and saliva that could contribute to host susceptibility to SARS-CoV-2 and the development of severe COVID-19. Methods: The COVID-19 Response Study aims to recruit 1000 people who recovered from SARS-CoV-2 infection in both community and hospital settings on the island of Ireland. This protocol describes the retrospective observational study component carried out in Northern Ireland (NI; Cohort A); the Republic of Ireland cohort will be described separately. For all NI participants (n=519), SARS-CoV-2 infection has been confirmed by reverse transcription -quantitative polymerase chain reaction. A prospective Cohort B of 40 patients is also being followed up at 1, 3, 6, and 12 months postinfection to assess longitudinal symptom frequency and immune response. Data will be sourced from whole blood, saliva samples, and clinical data from the electronic care records, the general health questionnaire, and a 12 -item general health questionnaire mental health survey. Saliva and blood samples were processed to extract DNA and RNA before whole-genome sequencing, RNA sequencing, DNA methylation analysis, microbiome analysis, 16S ribosomal RNA gene sequencing, and proteomic analys, Funding Agencies|Department for the Economy Northern Ireland; Opportunity-Led Research Awards; HSC Research and Development Division, Public Health Agency [COM/5618/20, COM/5631/20]; United Kingdom Research and Innovation

Published
2024
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18. Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study (Preprint)

Author

English, Andrew, primary, McDaid, Darren, additional, Lynch, Seodhna M, additional, McLaughlin, Joseph, additional, Cooper, Eamonn, additional, Wingfield, Benjamin, additional, Kelly, Martin, additional, Bhavsar, Manav, additional, McGilligan, Victoria, additional, Irwin, Rachelle E, additional, Bucholc, Magda, additional, Zhang, Shu-Dong, additional, Shukla, Priyank, additional, Rai, Taranjit Singh, additional, Bjourson, Anthony J, additional, Murray, Elaine, additional, Gibson, David S, additional, and Walsh, Colum, additional

Published
2023
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19. Inflammatory and immune response signatures associated with COVID-19 severity

Author

Gibson, David S, primary, McLaughlin, Joseph, additional, McDaid, Darren, additional, Lynch, Seodhna, additional, OKane, Maurice, additional, Kelly, Martin, additional, Bhavsar, Manav, additional, McGilligan, Victoria, additional, Shukla, Priyank, additional, Zhang, Shu-Dong, additional, Murray, Elaine, additional, Rai, Taranjit Singh, additional, Walsh, Colum, additional, and Bjourson, Anthony J, additional

Published
2023
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21. College Student Mental Health and Wellbeing Prior to and during the COVID-19 Pandemic

Author

McLafferty, Margaret, Ward, Caoimhe, Walsh, Colum, O'Neill, Siobhan, Bjourson, Anthony J., Mchugh, Rachel, Brown, Natasha, McBride, Louise, Brady, John, Murray, Elaine K., McLafferty, Margaret, Ward, Caoimhe, Walsh, Colum, O'Neill, Siobhan, Bjourson, Anthony J., Mchugh, Rachel, Brown, Natasha, McBride, Louise, Brady, John, and Murray, Elaine K.

Abstract

Student mental health was a growing concern globally prior to the onset of the COVID-19 pandemic. The aim of this study was to assess the impact of the pandemic and associated restrictions on the psychological wellbeing of college students. Baseline data were collected pre-pandemic in September 2019 among students attending a university in Northern Ireland and an Institute of Technology in the Republic of Ireland. Surveys were also conducted with this cohort during the pandemic, at the start of the academic years 2020 and 2021 (499 students fully completed all three waves). A follow-up survey was conducted at the end of their third year, in summer 2022 (n = 229). High levels of mental health problems were already present among students commencing college. The subsequent pandemic had a very negative impact on student's academic experience and other aspects of life. Rates of depression (PHQ-9) increased significantly from the onset of the pandemic and remained high. Anxiety (GAD-7) initially decreased but then escalated at the end of college. The study highlights the importance of early intervention and makes recommendations for addressing the needs of students during times of stress. Additional supports may be required to deal with the long-lasting impact of the pandemic., Funding Agencies|Cross-border Healthcare Intervention Trials In Ireland Network (CHITIN)

Published
2023
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22. Supplementary Table S2 from Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma

Author

Rossman, Paul, primary, Zabka, Tanja S., primary, Ruple, Audrey, primary, Tuerck, Dietrich, primary, Ramos-Vara, José A., primary, Liu, Liling, primary, Mohallem, Rodrigo, primary, Merchant, Mark, primary, Franco, Jackeline, primary, Fulkerson, Christopher M., primary, Bhide, Ketaki P., primary, Breen, Matthew, primary, Aryal, Uma K., primary, Murray, Elaine, primary, Dybdal, Noel, primary, Utturkar, Sagar M., primary, Fourez, Lindsey M., primary, Enstrom, Alexander W., primary, Dhawan, Deepika, primary, and Knapp, Deborah W., primary

Published
2023
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23. Figure S3 from Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma

Author

Rossman, Paul, primary, Zabka, Tanja S., primary, Ruple, Audrey, primary, Tuerck, Dietrich, primary, Ramos-Vara, José A., primary, Liu, Liling, primary, Mohallem, Rodrigo, primary, Merchant, Mark, primary, Franco, Jackeline, primary, Fulkerson, Christopher M., primary, Bhide, Ketaki P., primary, Breen, Matthew, primary, Aryal, Uma K., primary, Murray, Elaine, primary, Dybdal, Noel, primary, Utturkar, Sagar M., primary, Fourez, Lindsey M., primary, Enstrom, Alexander W., primary, Dhawan, Deepika, primary, and Knapp, Deborah W., primary

Published
2023
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24. Supplemental Figure 3 from Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors

Author

Infante, Jeffrey R., primary, Hollebecque, Antoine, primary, Postel-Vinay, Sophie, primary, Bauer, Todd M., primary, Blackwood, Elizabeth M., primary, Evangelista, Marie, primary, Mahrus, Sami, primary, Peale, Franklin V., primary, Lu, Xuyang, primary, Sahasranaman, Srikumar, primary, Zhu, Rui, primary, Chen, Yuan, primary, Ding, Xiao, primary, Murray, Elaine R., primary, Schutzman, Jennifer L., primary, Lauchle, Jennifer O., primary, Soria, Jean-Charles, primary, and LoRusso, Patricia M., primary

Published
2023
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25. Supplemental Figure 2 from Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors

Author

Infante, Jeffrey R., primary, Hollebecque, Antoine, primary, Postel-Vinay, Sophie, primary, Bauer, Todd M., primary, Blackwood, Elizabeth M., primary, Evangelista, Marie, primary, Mahrus, Sami, primary, Peale, Franklin V., primary, Lu, Xuyang, primary, Sahasranaman, Srikumar, primary, Zhu, Rui, primary, Chen, Yuan, primary, Ding, Xiao, primary, Murray, Elaine R., primary, Schutzman, Jennifer L., primary, Lauchle, Jennifer O., primary, Soria, Jean-Charles, primary, and LoRusso, Patricia M., primary

Published
2023
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26. Supplementary Figure 2 from A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

Author

Varga, Andrea, primary, Soria, Jean-Charles, primary, Hollebecque, Antoine, primary, LoRusso, Patricia, primary, Bendell, Johanna, primary, Huang, Shih-Min A., primary, Wagle, Marie-Claire, primary, Okrah, Kwame, primary, Liu, Lichuan, primary, Murray, Elaine, primary, Sanabria-Bohorquez, Sandra M., primary, Tagen, Michael, primary, Dokainish, Hatem, primary, Mueller, Lars, primary, and Burris, Howard, primary

Published
2023
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27. Supplemental Figure 1 from Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors

Author

Infante, Jeffrey R., primary, Hollebecque, Antoine, primary, Postel-Vinay, Sophie, primary, Bauer, Todd M., primary, Blackwood, Elizabeth M., primary, Evangelista, Marie, primary, Mahrus, Sami, primary, Peale, Franklin V., primary, Lu, Xuyang, primary, Sahasranaman, Srikumar, primary, Zhu, Rui, primary, Chen, Yuan, primary, Ding, Xiao, primary, Murray, Elaine R., primary, Schutzman, Jennifer L., primary, Lauchle, Jennifer O., primary, Soria, Jean-Charles, primary, and LoRusso, Patricia M., primary

Published
2023
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28. Supplementary Figure 1 from A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

Author

Varga, Andrea, primary, Soria, Jean-Charles, primary, Hollebecque, Antoine, primary, LoRusso, Patricia, primary, Bendell, Johanna, primary, Huang, Shih-Min A., primary, Wagle, Marie-Claire, primary, Okrah, Kwame, primary, Liu, Lichuan, primary, Murray, Elaine, primary, Sanabria-Bohorquez, Sandra M., primary, Tagen, Michael, primary, Dokainish, Hatem, primary, Mueller, Lars, primary, and Burris, Howard, primary

Published
2023
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29. Supplementary Data from A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

Author

Varga, Andrea, primary, Soria, Jean-Charles, primary, Hollebecque, Antoine, primary, LoRusso, Patricia, primary, Bendell, Johanna, primary, Huang, Shih-Min A., primary, Wagle, Marie-Claire, primary, Okrah, Kwame, primary, Liu, Lichuan, primary, Murray, Elaine, primary, Sanabria-Bohorquez, Sandra M., primary, Tagen, Michael, primary, Dokainish, Hatem, primary, Mueller, Lars, primary, and Burris, Howard, primary

Published
2023
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30. Variations in psychological disorders, suicidality, and help-seeking behaviour among college students from different academic disciplines

Author

McLafferty, Margaret, primary, Brown, Natasha, additional, Brady, John, additional, McLaughlin, Jonathon, additional, McHugh, Rachel, additional, Ward, Caoimhe, additional, McBride, Louise, additional, Bjourson, Anthony J., additional, O’Neill, Siobhan M., additional, Walsh, Colum P., additional, and Murray, Elaine K., additional

Published
2022
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32. Variations in psychological disorders, suicidality, and help-seeking behaviour among college students from different academic disciplines

Author

McLafferty, Margaret, Brown, Natasha, Brady, John, McLaughlin, Jonathon, McHugh, Rachel, Ward, Caoimhe, McBride, Louise, Bjourson, Anthony J., O'Neill, Siobhan M., Walsh, Colum P., Murray, Elaine K., McLafferty, Margaret, Brown, Natasha, Brady, John, McLaughlin, Jonathon, McHugh, Rachel, Ward, Caoimhe, McBride, Louise, Bjourson, Anthony J., O'Neill, Siobhan M., Walsh, Colum P., and Murray, Elaine K.

Abstract

Background Elevated levels of suicidality, ADHD, mental ill-health and substance disorders are reported among college students globally, yet few receive treatment. Some faculties and courses appear to have more at-risk students than others. The current study aimed to determine if students commencing college in different academic disciplines were at a heightened risk for psychopathology, substance use disorders and suicidal behaviour, and examined variations in help-seeking behaviour. Materials and methods The study utilised data collected from 1,829 first-year undergraduate students as part of the Student Psychological Intervention Trial (SPIT) which commenced in September 2019 across four Ulster University campuses in Northern Ireland and an Institute of Technology, in the North-West of Ireland. The SPIT study is part of the World Mental Health International College Student Initiative (WMH-ICS) which uses the WMH-CIDI to identify 12-month and lifetime disorders. Results Students from Life and Health Sciences reported the lowest rates of a range of psychological problems in the year prior to commencing college, while participants studying Arts and Humanities displayed the highest levels (e.g. depression 20.6%; social anxiety 38.8%). However, within faculty variations were found. For example, psychology students reported high rates, while nursing students reported low rates. Variations in help seeking behaviour were also revealed, with male students less likely to seek help. Conclusions Detecting specific cohorts at risk of psychological disorders and suicidality is challenging. This study revealed that some academic disciplines have more vulnerable students than others, with many reluctant to seek help for their problems. It is important for educators to be aware of such issues and for colleges to provide information and support to students at risk. Tailored interventions and prevention strategies may be beneficial to address the needs of students from different dis

Published
2022
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36. Immuno-informatics analysis predicts B and T cell consensus epitopes for designing peptide vaccine against SARS-CoV-2 with 99.82% global population coverage

Author

Shukla, Priyank, primary, Pandey, Preeti, additional, Prasad, Bodhayan, additional, Robinson, Tony, additional, Purohit, Rituraj, additional, D’Cruz, Leon G, additional, Tambuwala, Murtaza M, additional, Mutreja, Ankur, additional, Harkin, Jim, additional, Rai, Taranjit Singh, additional, Murray, Elaine K, additional, Gibson, David S, additional, and Bjourson, Anthony J, additional

Published
2021
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37. Lifetime and 12-month treatment for mental disorders and suicidal thoughts and behaviors among first year college students

Author

Bruffaerts, Ronny, Mortier, Philippe, Auerbach, Randy P, Alonso, Jordi, Hermosillo De la Torre, Alicia E, Cuijpers, Pim, Demyttenaere, Koen, Ebert, David D, Green, Jennifer Greif, Hasking, Penelope, Stein, Dan J, Ennis, Edel, Nock, Matthew K, Pinder-Amaker, Stephanie, Sampson, Nancy A, Vilagut, Gemma, Zaslavsky, Alan M, Kessler, Ronald C, Boyes, Mark, Kiekens, Glenn, Bootsma, Erik, Husky, Mathilde, Kovess-Masfety, Viviane, Berking, Matthias, Franke, Marvin, Kaehlke, Fanny, Baumeister, Harald, Kuechler, Ann-Marie, Mak, Arthur, Siu-Oi-Ling, Benjet, Corina, Borges, Guilherme, Elena Medina-Mora, Maria, Abrego Ramirez, Adrian, Covarrubias Diaz, Anabell, Socorro Duran, Ma, Perez Tarango, Gustavo, Zavala Berbena, Maria Alicia, Gonzalez Gonzalez, Rogaciano, Gutierrez-Garcia, Raul A, Hermosillo De la Torre, Alicia Edith, Martinez Martinez, Kalina Isela, Martinez Ruiz, Sinead, Karyotaki, Eirini, O'Neill, Siobhan, Bjourson, Tony, Murray, Elaine, Lochner, Christine, Roos, Janine, Taljaard, Lian, Bantjes, Jason, Saal, Wylene, Alayo, Itxaso, Ballester, Laura, Jesus Blasco, Gabriela Barbaglia Maria, Castellvi, Pere, Isabel Cebria, Ana, Garcia-Forero, Carlos, Miranda-Mendizabal, Andrea, Pares-Badell, Oleguer, Almenara, Jose, Lagares, Carolina, Echeburua, Enrique, Gabilondo, Andrea, Iruin, Alvaro, Teresa Perez-Vazquez, Maria, Antonio Piqueras, Jose, Soto-Sanz, Victoria, Rodriguez-Marin, Jesus, Roca, Miquel, Gili, Margarida, Vives, Margarida, Green, Jennifer G, Clinical, Neuro- & Developmental Psychology, APH - Global Health, and APH - Mental Health

Subjects
Male, HELP-SEEKING, affective disorders, Psychological intervention, Health services, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Prevalence, health service, Receipt, Psychiatry, RISK, Mental Disorders, ALCOHOL-USE DISORDERS, DEPRESSION, anxiety, Mental health treatment, PREVALENCE, Psychiatry and Mental health, Anxiety, Female, medicine.symptom, Life Sciences & Biomedicine, medicine.medical_specialty, Universities, education, ORGANIZATION, World health, Special Issues, Unmet needs, Suicidal Ideation, IDENTIFICATION TEST AUDIT, 03 medical and health sciences, Young Adult, SDG 3 - Good Health and Well-being, medicine, PLANS, Humans, HEALTH-SERVICE UTILIZATION, IDEATION, Students, suicide, Health Services Needs and Demand, Science & Technology, business.industry, college students, 030227 psychiatry, business, 030217 neurology & neurosurgery
Abstract

OBJECTIVES: Mental disorders and suicidal thoughts and behaviors (STB) are common and burdensome among college students. Although available evidence suggests that only a small proportion of the students with these conditions receive treatment, broad-based data on patterns of treatment are lacking. The aim of this study is to examine the receipt of mental health treatment among college students cross-nationally. METHODS: Web-based self-report surveys were obtained from 13,984 first year students from 19 colleges in eight countries across the world as part of the World Health Organization's World Mental Health-International College Student Initiative. The survey assessed lifetime and 12-month common mental disorders/STB and treatment of these conditions. RESULTS: Lifetime and 12-month treatment rates were very low, with estimates of 25.3-36.3% for mental disorders and 29.5-36.1% for STB. Treatment was positively associated with STB severity. However, even among severe cases, lifetime and 12-month treatment rates were never higher than 60.0% and 45.1%, respectively. CONCLUSIONS: High unmet need for treatment of mental disorders and STB exists among college students. In order to resolve the problem of high unmet need, a reallocation of resources may focus on innovative, low-threshold, inexpensive, and scalable interventions. ispartof: INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH vol:28 issue:2 ispartof: location:United States status: published

Published
2019
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41. Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma

Author

Rossman, Paul, primary, Zabka, Tanja S., additional, Ruple, Audrey, additional, Tuerck, Dietrich, additional, Ramos-Vara, José A., additional, Liu, Liling, additional, Mohallem, Rodrigo, additional, Merchant, Mark, additional, Franco, Jackeline, additional, Fulkerson, Christopher M., additional, Bhide, Ketaki P., additional, Breen, Matthew, additional, Aryal, Uma K., additional, Murray, Elaine, additional, Dybdal, Noel, additional, Utturkar, Sagar M., additional, Fourez, Lindsey M., additional, Enstrom, Alexander W., additional, Dhawan, Deepika, additional, and Knapp, Deborah W., additional

Published
2021
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42. ALLO-647 for Lymphodepletion in the Allogeneic CAR T Setting: Safety Experience with ALLO-501/501A in Patients (Pts) with Relapsed/Refractory (r/r) Large B-Cell and Follicular Lymphomas

Author

Locke, Frederick L., Munoz, Javier L., Tees, Michael T., Lekakis, Lazaros J., Eradat, Herbert A., de Vos, Sven, Nath, Rajneesh, Stevens, Don A., Malik, Shahbaz A., Shouse, Geoffrey P., Hamadani, Mehdi, Oluwole, Olalekan O., Perales, Miguel-Angel, Miklos, David B., Nguyen, Anh, Feng, Amy, Navale, Lynn, Murray, Elaine, Kaufman, Greg P., Kai, Kazuharu, Le Gall, John B., and Neelapu, Sattva S.

Published
2023
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45. Regional planning for the siting of local evaporation basins for the disposal of saline irrigation drainage: development and testing of a GIS-based suitability approach

Author

Jolly, Ian D., Walker, Glen R., Dowling, Trevor I., Christen, Evan W., and Murray, Elaine

Subjects
Saline irrigation -- Waste management, Evaporation -- Management, Environmental impact analysis -- Methods, Geographic information systems -- Usage, Environmental issues
Abstract

Research in Australia's Riverine Plain shows that a geographic information systems method is a suitable means for assessing environmental impacts. The method was weaker for interpolated point data parameters such as hydraulic conductivity and salinity, but it demonstrated higher confidence with more defined parameters such as proximity to urban areas and surface water features.

Published
2001

46. A Phase Ib Study to Evaluate the MEK Inhibitor Cobimetinib in Combination with the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

Author

Weekes, Colin, primary, Lockhart, Albert, additional, LoRusso, Patricia, additional, Murray, Elaine, additional, Park, Erica, additional, Tagen, Mike, additional, Singh, Jatinder, additional, Sarkar, Indrani, additional, Mueller, Lars, additional, Dokainish, Hatem, additional, Shapiro, Geoffrey, additional, and Burris, Howard, additional

Published
2020
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48. A First-in-Human Phase I Study to Evaluate the ERK1/2 Inhibitor GDC-0994 in Patients with Advanced Solid Tumors

Author

Varga, Andrea, primary, Soria, Jean-Charles, additional, Hollebecque, Antoine, additional, LoRusso, Patricia, additional, Bendell, Johanna, additional, Huang, Shih-Min A., additional, Wagle, Marie-Claire, additional, Okrah, Kwame, additional, Liu, Lichuan, additional, Murray, Elaine, additional, Sanabria-Bohorquez, Sandra M., additional, Tagen, Michael, additional, Dokainish, Hatem, additional, Mueller, Lars, additional, and Burris, Howard, additional

Published
2020
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