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Abstract Some capture–recapture models for population estimation cannot easily be fitted by the usual methods (maximum likelihood and Markov‐chain Monte Carlo). For example, there is no straightforward probability model for the capture of animals in traps that hold a maximum of one individual (‘single‐catch traps’), yet such data are commonly collected. It is usual to ignore the limit on individuals per trap and analyse with a competing‐risk ‘multi‐catch’ model that gives unbiased estimates of average density. However, that approach breaks down for models with varying density. Simulation and inverse prediction was suggested by Efford (2004) for estimating population density with data from single‐catch traps, but the method has been little used, in part because the existing software allows only a narrow range of models. I describe a new R package that refines the method and extends it to include models with varying density, trap interference and other sources of non‐independence among detection histories. The method depends on (i) a function of the data that generates a proxy for each parameter of interest and (ii) functions to simulate new datasets given values of the parameters. By simulating many datasets, it is possible to infer the relationship between proxies and parameters and, by inverting that relationship, to estimate the parameters from the observed data. The method is applied to data from a trapping study of brushtail possums Trichosurus vulpecula in New Zealand. A feature of these data is the high frequency of non‐capture events that disabled traps (interference). Allowing for a time‐varying interference process in a model fitted by simulation and inverse prediction increased the steepness of inferred year‐on‐year population decline. Drawbacks and possible extensions of the method are discussed.

The supraspinal connectome is essential for normal behavior and homeostasis and consists of numerous sensory, motor, and autonomic projections from brain to spinal cord. Study of supraspinal control and its restoration after damage has focused mostly on a handful of major populations that carry motor commands, with only limited consideration of dozens more that provide autonomic or crucial motor modulation. Here, we assemble an experimental workflow to rapidly profile the entire supraspinal mesoconnectome in adult mice and disseminate the output in a web-based resource. Optimized viral labeling, 3D imaging, and registration to a mouse digital neuroanatomical atlas assigned tens of thousands of supraspinal neurons to 69 identified regions. We demonstrate the ability of this approach to clarify essential points of topographic mapping between spinal levels, measure population-specific sensitivity to spinal injury, and test the relationships between region-specific neuronal sparing and variability in functional recovery. This work will spur progress by broadening understanding of essential but understudied supraspinal populations.

After injury to the nervous system, many neurons fail to initiate transcriptional programs needed for axon growth. Here the authors examine co-operative binding of factors to regulatory DNA to predict combinations that improve axon growth when ectopically co-expressed.

Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations. Chondroitin sulfate proteoglycans (CSPGs) are well-studied inhibitors of axon growth in the CNS, and degradation of CSPGs by chondroitinase has been shown to improve the extension of injured axons. Alternatively, axon growth can be improved by targeting the neuron-intrinsic growth capacity through forced expression of regeneration-associated transcription factors. For example, a transcriptionally active chimera of Krüppel-like Factor 7 (KLF7) and a VP16 domain improves axon growth when expressed in corticospinal tract neurons. Here we tested the hypothesis that combined expression of chondroitinase and VP16-KLF7 would lead to further improvements in axon growth after spinal injury. Chondroitinase was expressed by viral transduction of cells in the spinal cord, while VP16-KLF7 was virally expressed in sensory neurons of the dorsal root ganglia or corticospinal tract (CST) neurons. After transection of the dorsal columns, both chondroitinase and VP16-KLF7 increased the proximity of severed sensory axons to the injury site. Similarly, after complete crush injuries, VP16-KLF7 expression increased the approach of CST axons to the injury site. In neither paradigm however, did single or combined treatment with chondroitinase or VP16-KLF7 enable regenerative growth distal to the injury. These results substantiate a role for CSPG inhibition and low KLF7 activity in determining the net retraction of axons from sites of spinal injury, while suggesting that additional factors act to limit a full regenerative response.

BackgroundGiven the likelihood of progressive illness in bipolar disorder (BD), it is important to understand the benefits and risks of interventions administered early in illness course. We conducted a systematic review of the effectiveness of interventions in the early course of BD I or II.MethodsWe completed a systematic search on MEDLINE, PsycINFO, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL and Google Scholar from 1/1/1979 till 14/9/2022. We included controlled trials examining intervention effects on symptomatic, course, functional and tolerability outcomes of patients in the 'early course' of BD I or II. We classified patients to be in early course if they (a) were seeking help for the first time for a manic episode, (b) had a lifetime history of up to 3 manic episodes, or (c) had up to 6 lifetime mood episodes. Evidence quality was assessed using the GRADE approach.ResultsFrom 4135 unique publications we included 25 reports representing 2212 participants in 16 randomized studies, and 17,714 participants from nine non-randomized studies. Available evidence suggested that in early illness course, lithium use was associated with lower recurrence risk compared with other mood stabilizers. Mood stabilizers were also associated with better global functioning, compared with the use of antipsychotics in the medium term. While summative findings regarding psychological therapies were limited by heterogeneity, family-focused and cognitive-behavioral interventions were associated with reduced recurrence risk or improved symptomatic outcomes. There was some evidence that the same pharmacological interventions were more efficacious in preventing recurrences when utilized in earlier rather than later illness course.Conclusions and recommendationsWhile there are promising initial findings, there is a need for more adequately powered trials to examine the efficacy and tolerability of interventions in youth and adults in early illness course. Specifically, there is a compelling need to compare the relative benefits of lithium with other pharmacological agents in preventing recurrences. In addition to symptomatic outcomes, there should be a greater focus on functional impact and tolerability. Effective pharmacological and psychological interventions should be offered to those in early course of BD, balancing potential risks using shared decision-making approaches.

INTRODUCTION: Multiple sclerosis (MS) is a chronic disease of the central nervous system. Estimates of MS natural history (NH) disability progression speed from clinical observations vary worldwide. This may reflect, in part, variance in censoring-bias) (missing observations) and assumptions about when irreversible disability progression events occurred. We test whether estimates of progression speed which assume midpoint survival time at irreversible disability endpoints are significantly faster than estimates which assume maximum survival time, and are more stable across study groups and time periods. METHODS: Our Nova Scotia NH study population includes 2,240 definite relapsing-onset multiple sclerosis (R-MS) natural history patients with 18,078 Expanded Disability Status Scale (EDSS) clinical observations in study period 1979-2010. Progression speed is measured by rate-of-change in range EDSS 0-6 and by survival time at irreversible endpoints EDSS 1-9. Midpoint censoring-bias-reduction methods are applied to clinical observations. FINDINGS: Typical EDSS increase per year in range EDSS 0-6, assuming midpoint survival time, is estimated to be 0.168 for all R-MS, 0.204 for eventually-DMD-treated patients and 0.155 for never-DMD-treated patients. Estimates assuming midpoint rather than maximum survival time are significantly faster: 16% faster for all R-MS natural history patients, 6% faster for eventually-DMD-treated patients, and 21% faster for never-DMD-treated patients. The variability of estimates across study groups and time periods decreased when midpoint survival time was assumed. CONCLUSIONS: Estimates of typical disease progression speed from 1979-2010 Nova Scotia clinical observations are sensitive to censoring-bias and to analysts' survival time assumptions. Censoring-bias-adjusted estimates of typical natural history disability progression speed in relapsing-onset multiple sclerosis patients are significantly faster, and less variable within and across study groups and time periods, than unadjusted estimates, and are, arguably, more relevant for various stakeholders. The application of censoring-bias-reduction methods to other multiple sclerosis clinical databases may reduce variability in estimates of disability progression speed worldwide.

BACKGROUND: Colorectal cancer (CRC) is the second most common invasive cancer in Canada. Estimates of the costs of care allow estimation of the cost effectiveness of screening for premalignant and early disease.

In this paper, we use the field of Health and Physical Education (H/PE) to explain the limitations, nuances, and inconsistencies of three global, digitally available, and regularly updated systems: library holdings, metrics, and altmetrics. We understand these systems through the analogy of seeing different vistas of a landscape when driving a car: looking in the rear-view mirror (i.e. library holdings as past indicators of quality) and out the side windows (i.e. metrics and altmetrics as current indicators). Before examining these measures, we acknowledge the neoliberal audit culture and outline our understanding of the H/PE 'field'. To identify H/PE journals, we searched databases, websites, and literature, generating a list of 202 potentially relevant journals. After three rounds of refinement, 13 journals remained that: (1) focused on health and/or physical education as a school subject (including H/PE teacher education), (2) had official metrics, and (3) self-identified as 'Social Sciences-Education' and had more than 20% of the papers in the last two volumes focus on H/PE. For each of these journals, we provide the WorldCat library holdings, metrics (i.e. Journal Impact Factor, Journal h-index, CiteScore, SCImago Journal Rank, and Source Normalized Impact per Paper), and altmetrics. We explain how to understand these measures, as well as their contested, problematic and, often, confusing dimensions. Overall, we argue that it is crucial for scholars to understand these measures so that they can critically reflect on how measurement shapes their research and professional lives.

Traditional games are often situated in counter distinction to modern sport forms and are not well understood in Western society or scholarship. However, from these games, we have the opportunity to learn much about local play and physical culture. This article focuses on traditional Indigenous games in Oceania and how they can be used as a lens for the development of environmental stewardship or ecological sensibilities. The aims of this study are twofold: (1) to lay a foundation for future research in this area and (2) to situate traditional games within the broader sport ecology conversation. By deconstructing the embodied nature of traditional games and overviewing the histories of environmentalism in Oceania, a more grounded claim can be made for the relevance of traditional games within sport and leisure studies scholarship, including sport history, sport sociology, sport anthropology, and sport ecology. The nature games of Oceania yield diverse insights into Indigenous epistemologies, ecological sensibilities, and how outdoor play can be understood as a form of climate action. [ABSTRACT FROM AUTHOR]