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5 results on '"Murugavelu, Praveenkumar"'

2. A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern

Author

Parray, Hilal Ahmad, primary, Narayanan, Naveen, additional, Garg, Sonal, additional, Rizvi, Zaigham Abbas, additional, Shrivastava, Tripti, additional, Kushwaha, Sachin, additional, Singh, Janmejay, additional, Murugavelu, Praveenkumar, additional, Anantharaj, Anbalagan, additional, Mehdi, Farha, additional, Raj, Nisha, additional, Singh, Shivam, additional, Dandotiya, Jyotsna, additional, Lukose, Asha, additional, Jamwal, Deepti, additional, Kumar, Sandeep, additional, Chiranjivi, Adarsh K., additional, Dhyani, Samridhi, additional, Mishra, Nitesh, additional, Kumar, Sanjeev, additional, Jakhar, Kamini, additional, Sonar, Sudipta, additional, Panchal, Anil Kumar, additional, Tripathy, Manas Ranjan, additional, Chowdhury, Shirlie Roy, additional, Ahmed, Shubbir, additional, Samal, Sweety, additional, Mani, Shailendra, additional, Bhattacharyya, Sankar, additional, Das, Supratik, additional, Sinha, Subrata, additional, Luthra, Kalpana, additional, Batra, Gaurav, additional, Sehgal, Devinder, additional, Medigeshi, Guruprasad R., additional, Sharma, Chandresh, additional, Awasthi, Amit, additional, Garg, Pramod Kumar, additional, Nair, Deepak T., additional, and Kumar, Rajesh, additional

Published
2022
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3. A broadly neutralising monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV2 variant of concerns

Author

Kumar, Rajesh, primary, Parray, Hilal, additional, Narayan, Naveen, additional, Garg, Sonal, additional, Rizvi, Zaigham Abbas, additional, Shrivastava, Tripti, additional, Kushwaha, Sachin, additional, Singh, Janmejay, additional, Murugavelu, Praveenkumar, additional, Anantharaj, Anbalagan, additional, Mehdi, Farha, additional, Raj, Nisha, additional, Singh, Shivam, additional, Dandotiya, Jyotsna, additional, Lukose, Asha, additional, Jamwal, Deepti, additional, Kumar, Sandeep, additional, Chiranjivi, Adarsh, additional, Dhyani, Samridhi, additional, Mishra, Nitesh, additional, Jakhar, Kamini, additional, Sonar, Sudipta, additional, Chowdhury, Shirlie, additional, Panchal, Anil, additional, Tripathy, Manas, additional, Ahmed, Shubbir, additional, Samal, Sweety, additional, Mani, Shailendra, additional, Bhattacharyya, Sankar, additional, Das, Supratik, additional, Sinha, Subrata, additional, Batra, Gaurav, additional, Sehgal, Devinder, additional, Medigeshi, Guruprasad, additional, Sharma, Chandresh, additional, Awasthi, Amit, additional, Garg, Pramod, additional, and Nair, Deepak, additional

Published
2022
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4. The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Human immunodeficiency virus (HIV-1) gp41

Author

Reema, Tripti Shrivastava, Sankar Bhattacharyya, Adarsh Kumar Chiranjivi, Supratik Das, Anil Kumar Panchal, S. K. Singh, Chandresh Sharma, Kalpana Luthra, Rajesh Kumar, Hilal Ahmed Parray, Vanshika Singh, Kamini Jakhar, M. Tiwari, Shailendra Mani, Murugavelu PraveenKumar, Sudipta Sonar, Deepak K. Rathore, Reshma Perween, Sweety Samal, and Shubbir Ahamed

Subjects
viruses, Immunology, Cross Reactions, Gp41, medicine.disease_cause, Antibodies, Viral, Cross-reactivity, Neutralization, Epitope, Article, Antigen, medicine, Immunology and Allergy, Animals, Class I viruses, Pharmacology, Mice, Inbred BALB C, biology, RNA, virus diseases, Non-neutralizing antibodies, Virology, HIV Envelope Protein gp41, Recombinant Proteins, Mice, Inbred C57BL, Polyclonal antibodies, Spike Glycoprotein, Coronavirus, SARS-CoV2, biology.protein, HIV-1, Antibody
Abstract

Cross-reactivity among the two diverse viruses is believed to originate from the concept of antibodies recognizing similar epitopes on the two viral surfaces. Cross-reactive antibody responses have been seen in previous variants of SARS and SARS-CoV-2, but little is known about the cross reactivity with other similar RNA viruses like HIV-1. In the present study, we examined the reactivity the SARS-CoV-2 directed antibodies, via spike, immunized mice sera and demonstrated whether they conferred any cross-reactive neutralization against HIV-1. Our findings show that SARS-CoV-2 spike immunized mice antibodies cross-react with the HIV-1 Env protein. Cross-neutralization among the two viruses is uncommon, suggesting the presence of a non-neutralizing antibody response to conserved epitopes amongst the two viruses. Our results indicate, that SARS-CoV-2 spike antibody cross reactivity is targeted towards the gp41 region of the HIV-1 Env (gp160) protein. Overall, our investigation not only answers a crucial question about the understanding of cross-reactive epitopes of antibodies generated in different viral infections, but also provides critical evidence for developing vaccine immunogens and novel treatment strategies with enhanced efficacy capable of recognising diverse pathogens with similar antigenic features.

Published
2021

5. Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virus

Author

Murugavelu, Praveenkumar, primary, Perween, Reshma, additional, Shrivastava, Tripti, additional, Singh, Vanshika, additional, Ahmad Parray, Hilal, additional, Singh, Swarandeep, additional, Chiranjivi, Adarsh Kumar, additional, Thiruvengadam, Ramachandran, additional, Singh, Savita, additional, Yadav, Naveen, additional, Jakhar, Kamini, additional, Sonar, Sudipta, additional, Mani, Shailendra, additional, Bhattacharyya, Sankar, additional, Sharma, Chandresh, additional, Vishwakarma, Preeti, additional, Khatri, Ritika, additional, Kumar Panchal, Anil, additional, Das, Supratik, additional, Ahmed, Shubbir, additional, Samal, Sweety, additional, Kshetrapal, Pallavi, additional, Bhatnagar, Shinjini, additional, Luthra, Kalpana, additional, and Kumar, Rajesh, additional

Published
2021
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