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210 results on '"Muse, Victorine"'

7. Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models

Author

Haft-Javaherian, Mohammad, Fang, Linjing, Muse, Victorine, Schaffer, Chris B., Nishimura, Nozomi, and Sabuncu, Mert R.

Subjects
Computer Science - Computer Vision and Pattern Recognition, I.2.1, I.2.6, I.4.3, I.4.6, I.5.1, I.5.4
Abstract

The health and function of tissue rely on its vasculature network to provide reliable blood perfusion. Volumetric imaging approaches, such as multiphoton microscopy, are able to generate detailed 3D images of blood vessels that could contribute to our understanding of the role of vascular structure in normal physiology and in disease mechanisms. The segmentation of vessels, a core image analysis problem, is a bottleneck that has prevented the systematic comparison of 3D vascular architecture across experimental populations. We explored the use of convolutional neural networks to segment 3D vessels within volumetric in vivo images acquired by multiphoton microscopy. We evaluated different network architectures and machine learning techniques in the context of this segmentation problem. We show that our optimized convolutional neural network architecture, which we call DeepVess, yielded a segmentation accuracy that was better than both the current state-of-the-art and a trained human annotator, while also being orders of magnitude faster. To explore the effects of aging and Alzheimer's disease on capillaries, we applied DeepVess to 3D images of cortical blood vessels in young and old mouse models of Alzheimer's disease and wild type littermates. We found little difference in the distribution of capillary diameter or tortuosity between these groups, but did note a decrease in the number of longer capillary segments ($>75\mu m$) in aged animals as compared to young, in both wild type and Alzheimer's disease mouse models., Comment: 34 pages, 9 figures

Published
2018
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8. Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models

Author

Cruz Hernández, Jean C, Bracko, Oliver, Kersbergen, Calvin J, Muse, Victorine, Haft-Javaherian, Mohammad, Berg, Maxime, Park, Laibaik, Vinarcsik, Lindsay K, Ivasyk, Iryna, Rivera, Daniel A, Kang, Yiming, Cortes-Canteli, Marta, Peyrounette, Myriam, Doyeux, Vincent, Smith, Amy, Zhou, Joan, Otte, Gabriel, Beverly, Jeffrey D, Davenport, Elizabeth, Davit, Yohan, Lin, Charles P, Strickland, Sidney, Iadecola, Costantino, Lorthois, Sylvie, Nishimura, Nozomi, and Schaffer, Chris B

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Behavioral and Social Science, Neurodegenerative, Basic Behavioral and Social Science, Aging, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Alzheimer Disease, Amyloid beta-Peptides, Animals, Antibodies, Antigens, Ly, Brain, Capillaries, Disease Models, Animal, Female, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Models, Neurological, Neutrophils, Peptide Fragments, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse models have been recognized for decades, but the underlying mechanisms and resulting consequences for Alzheimer's disease pathogenesis remain poorly understood. In APP/PS1 and 5xFAD mice we found that an increased number of cortical capillaries had stalled blood flow as compared to in wild-type animals, largely due to neutrophils that had adhered in capillary segments and blocked blood flow. Administration of antibodies against the neutrophil marker Ly6G reduced the number of stalled capillaries, leading to both an immediate increase in CBF and rapidly improved performance in spatial and working memory tasks. This study identified a previously uncharacterized cellular mechanism that explains the majority of the CBF reduction seen in two mouse models of Alzheimer's disease and demonstrated that improving CBF rapidly enhanced short-term memory function. Restoring cerebral perfusion by preventing neutrophil adhesion may provide a strategy for improving cognition in Alzheimer's disease patients.

Published
2019

12. Subgrouping multimorbid patients with ischemic heart disease by means of unsupervised clustering: A cohort study of 72,249 patients defined comprehensively by diagnoses prior to presentation

Author

Haue, Amalie D., primary, Holm, Peter C., additional, Banasik, Karina, additional, Lundgaard, Agnete T., additional, Muse, Victorine P., additional, Röder, Timo, additional, Westergaard, David, additional, Chmura, Piotr J., additional, Christensen, Alex H., additional, Weeke, Peter E., additional, Sørensen, Erik, additional, Pedersen, Ole B. V., additional, Ostrowski, Sisse R., additional, Iversen, Kasper K., additional, Køber, Lars V., additional, Ullum, Henrik, additional, Bundgaard, Henning, additional, and Brunak, Søren, additional

Published
2023
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13. High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

Author

Bracko, Oliver, Vinarcsik, Lindsay K., Cruz Hernández, Jean C., Ruiz-Uribe, Nancy E., Haft-Javaherian, Mohammad, Falkenhain, Kaja, Ramanauskaite, Egle M., Ali, Muhammad, Mohapatra, Aditi, Swallow, Madisen A., Njiru, Brendah N., Muse, Victorine, Michelucci, Pietro E., Nishimura, Nozomi, and Schaffer, Chris B.

Published
2020
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14. Evaluation of an Artificial Intelligence Model for Detection of Pneumothorax and Tension Pneumothorax in Chest Radiographs

Author

Hillis, James M., primary, Bizzo, Bernardo C., additional, Mercaldo, Sarah, additional, Chin, John K., additional, Newbury-Chaet, Isabella, additional, Digumarthy, Subba R., additional, Gilman, Matthew D., additional, Muse, Victorine V., additional, Bottrell, Georgie, additional, Seah, Jarrel C.Y., additional, Jones, Catherine M., additional, Kalra, Mannudeep K., additional, and Dreyer, Keith J., additional

Published
2022
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16. On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Author

McAleer, Christopher W., Pointon, Amy, Long, Christopher J., Brighton, Rocky L., Wilkin, Benjamin D., Bridges, L. Richard, Narasimhan Sriram, Narasimham, Fabre, Kristin, McDougall, Robin, Muse, Victorine P., Mettetal, Jerome T., Srivastava, Abhishek, Williams, Dominic, Schnepper, Mark T., Roles, Jeff L., Shuler, Michael L., Hickman, James J., and Ewart, Lorna

Published
2019
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18. Association of Artificial Intelligence–Aided Chest Radiograph Interpretation With Reader Performance and Efficiency

Author

Ahn, Jong Seok, primary, Ebrahimian, Shadi, additional, McDermott, Shaunagh, additional, Lee, Sanghyup, additional, Naccarato, Laura, additional, Di Capua, John F., additional, Wu, Markus Y., additional, Zhang, Eric W., additional, Muse, Victorine, additional, Miller, Benjamin, additional, Sabzalipour, Farid, additional, Bizzo, Bernardo C., additional, Dreyer, Keith J., additional, Kaviani, Parisa, additional, Digumarthy, Subba R., additional, and Kalra, Mannudeep K., additional

Published
2022
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20. Evaluation of an artificial intelligence model for detection of pneumothorax and tension pneumothorax on chest radiograph

Author

Hillis, James Michael, primary, Bizzo, Bernardo C, additional, Mercaldo, Sarah, additional, Chin, John K, additional, Newbury-Chaet, Isabella, additional, Digumarthy, Subba R, additional, Gilman, Matthew D, additional, Muse, Victorine V, additional, Bottrell, Georgie, additional, Seah, Jarrel CY, additional, Jones, Catherine M, additional, Kalra, Mannudeep K, additional, and Dreyer, Keith J, additional

Published
2022
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22. An Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy From a Multicenter Study

Author

Homayounieh, Fatemeh, primary, Digumarthy, Subba, additional, Ebrahimian, Shadi, additional, Rueckel, Johannes, additional, Hoppe, Boj Friedrich, additional, Sabel, Bastian Oliver, additional, Conjeti, Sailesh, additional, Ridder, Karsten, additional, Sistermanns, Markus, additional, Wang, Lei, additional, Preuhs, Alexander, additional, Ghesu, Florin, additional, Mansoor, Awais, additional, Moghbel, Mateen, additional, Botwin, Ariel, additional, Singh, Ramandeep, additional, Cartmell, Samuel, additional, Patti, John, additional, Huemmer, Christian, additional, Fieselmann, Andreas, additional, Joerger, Clemens, additional, Mirshahzadeh, Negar, additional, Muse, Victorine, additional, and Kalra, Mannudeep, additional

Published
2021
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23. Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes

Author

Vasalou, Christina, primary, Ferguson, Douglas, additional, Li, Weimin, additional, Muse, Victorine, additional, Gibbons, Francis D., additional, Sonzini, Silvia, additional, Zhang, Guangnong, additional, Pop-Damkov, Petar, additional, Gangl, Eric, additional, Balachander, Srividya B., additional, Wen, Shenghua, additional, Schuller, Alwin G., additional, Puri, Sanyogitta, additional, Mazza, Mariarosa, additional, Ashford, Marianne, additional, Fretland, Adrian J., additional, McGinnity, Dermot F., additional, and Jones, Rhys D. O., additional

Published
2021
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26. Case 29-2009: an 81-year-old man with weight loss, odynophagia, and failure to thrive

Author

Stone, Valerie E., Bounds, Brenna C., Muse, Victorine V., and Ferry, Judith A.

Subjects
AIDS (Disease) -- Case studies, AIDS (Disease) -- Diagnosis, AIDS (Disease) -- Care and treatment, Diabetes -- Case studies, Diabetes -- Diagnosis, Diabetes -- Care and treatment, Weight loss -- Case studies, Weight loss -- Causes of, Weight loss -- Care and treatment
Abstract

The case of an 81-year old man who is suffering from weight loss and odynophagia is discussed to better understand the causes, symptoms, diagnosis and treatment pf advanced HIV infection. The need and importance of early detection of HIV infection through HIV testing is highlighted.

Published
2009

28. Case 33-2008: a 63-year-old woman with dyspnea on exertion

Author

Wiener, Charles M., Muse, Victorine V., and Mark, Eugene J.

Subjects
Balsalazide -- Complications and side effects, Shortness of breath -- Causes of, Shortness of breath -- Diagnosis, Shortness of breath -- Care and treatment, Shortness of breath -- Case studies, Aged women -- Health aspects, Infliximab -- Complications and side effects, Lung diseases -- Risk factors
Abstract

The article discusses the symptoms, diagnosis and treatment methodologies for drug-induced lung disease caused due to either infliximab or balsalazide. A case study of a 63-year-old woman with dyspnea on exertion is highlighted to better understand the reasons behind drug-induced lung disease.

Published
2008

29. Case 19-2008: a 63-year-old HIV-positive man with cutaneous merkel-cell carcinoma

Author

Busse, Paul M., Clark, John R., Muse, Victorine V., and Liu, Vincent

Subjects
Skin cancer, HIV patients
Abstract

The symptoms, causes and management of merkel-cell carcinoma, an uncommon skin cancer are discussed. A case study f a 63-year-old HIV-positive man is investigated to get a better understanding of the disease.

Published
2008

31. Case 25-2007: A 60-year-old man with fever, odynophagia, weight loss, and rash

Author

Murali, Mandakolathur R., Mackool, Bonnie T., Muse, Victorine V., Zembowicz, Artur, and Ferry, Judith A.

Subjects
Fever -- Case studies, Hyperthermia -- Case studies, Weight loss -- Case studies, Rash (Dermatology) -- Case studies
Abstract

The article reviews and presents the handling of a medical case of a 60-year-old man with fever, odynophagia, weight loss, and rash.

Published
2007

32. Case 3-0-2006: A 41-year-old man with dyspnea, fever and lymphadenopathy

Author

&Scadden, David T., &Muse, Victorine V., and &Hasserjian, Robert P.

Subjects
HIV infection -- Complications and side effects, HIV infection -- Case studies, Lymphoproliferative disorders -- Risk factors, Lymphoproliferative disorders -- Case studies, HIV patients -- Health aspects
Abstract

A case study of a 41-year old man is presented which illustrates one important manifestation of HIV infection and bone marrow dysfunction. The diagnosis is that the patient probably acquired an infection with HIV between 1 and 4 years before admission, and as the infection progressed to AIDS he either became infected with HHV-8 or the virus became reactivated in the six months before admission, causing multicentric Castleman's disease.

Published
2006

34. Case 12:2003: AN 82-year-old man with dyspnea and pulmonary abnormalities

Author

Malhotra, Atul, Muse, Victorine V., and Mark, Eugene J.

Subjects
Amiodarone -- Adverse and side effects, Bacterial pneumonia -- Causes of, Pneumonia
Abstract

An 82-year-old man with shortness of breath and fluid retention was found to have lung disease caused by the anti-arrhythmia drug amiodarone. He was taking the drug to treat a heart arrhythmia called ventricular tachycardia. He was successfully treated.

Published
2003

35. Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes.

Author

Vasalou, Christina, Ferguson, Douglas, Weimin Li, Muse, Victorine, Gibbons, Francis D., Sonzini, Silvia, Guangnong Zhang, Pop-Damkov, Petar, Gangl, Eric, Balachander, Srividya B., Shenghua Wen, Schuller, Alwin G., Puri, Sanyogitta, Mazza, Mariarosa, Ashford, Marianne, Fretland, Adrian J., McGinnity, Dermot F., and Jones, Rhys D. O.

Published
2022
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40. Image Quality and Lesion Detection on Deep Learning Reconstruction and Iterative Reconstruction of Submillisievert Chest and Abdominal CT

Author

Singh, Ramandeep, primary, Digumarthy, Subba R., additional, Muse, Victorine V., additional, Kambadakone, Avinash R., additional, Blake, Michael A., additional, Tabari, Azadeh, additional, Hoi, Yiemeng, additional, Akino, Naruomi, additional, Angel, Erin, additional, Madan, Rachna, additional, and Kalra, Mannudeep K., additional

Published
2020
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48. Needle localization of peripheral lung nodules for video-assisted thoracoscopic surgery

Author

Shepard, Jo-Anne O., Mathisen, Douglas J., Muse, Victorine V., Bhalla, Meenakshi, and McLoud, Theresa C.

Subjects
Thoracoscopy -- Methods, Biopsy, Needle -- Methods, Health, Methods
Abstract

Video-assisted thoracoscopic surgery provides an alternative to conventional thoracotomy for resection of peripheral lung nodules. To localize small peripheral lung nodules that may not be visible or palpable by the [...]

Published
1994

49. O2‐12‐04: STALLED BLOOD FLOW IN BRAIN CAPILLARIES IS RESPONSIBLE FOR REDUCED CORTICAL PERFUSION AND IMPACTS COGNITIVE FUNCTION IN MOUSE MODELS OF ALZHEIMER'S DISEASE

Author

Bracko, Oliver, primary, Cruz Hernandez, Jean C., additional, Njiru, Brendah N., additional, Swallow, Madison, additional, Zheng, Jieyu, additional, Ali, Muhammad, additional, Kersbergen, Calvin, additional, Muse, Victorine, additional, Haft-Javaherian, Mohammad, additional, Park, Laibaik, additional, Vinarcsik, Lindsay K., additional, Ivasyk, Iryna, additional, Kang, Yiming, additional, Zhou, Joan, additional, Otte, Gabriel, additional, Beverly, Jeffrey D., additional, Slack, Elizabeth, additional, Iadecola, Costantino, additional, Nishimura, Nozomi, additional, and Schaffer, Chris B., additional

Published
2018
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