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1. Soil Erosion Assessment and Mitigation Scenarios Based on Geopedology in Northwestern Patagonia, Argentina

Author: Frugoni, M. C., González Musso, R. F., Falbo, G., Zinck, Joseph Alfred, editor, Metternicht, Graciela, editor, del Valle, Héctor Francisco, editor, and Angelini, Marcos, editor
Published: 2023
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2. Velocity-resolved reverberation mapping of five bright Seyfert 1 galaxies

Author: De Rosa, G., Fausnaugh, M. M., Grier, C. J., Peterson, B. M., Denney, K. D., Horne, Keith, Bentz, M. C., Ciroi, S., Bonta`, E. Dalla, Joner, M. D., Kaspi, S., Kochanek, C. S., Pogge, R. W., Sergeev, S. G., Vestergaard, M., Adams, S. M., Antognini, J., Salvo, C. Araya, Armstrong, E., Bae, J., Barth, A. J., Beatty, T. G., Bhattacharjee, A., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brown, J. E., Brown, J. S., Brotherton, M. S., Coker, C. T., Clanton, C., Cracco, V., Crawford, S. M., Croxall, K. V., Eftekharzadeh, S., Eracleous, M., Fiorenza, S. L., Frassati, A., Hawkins, K., Henderson, C. B., Holoien, T. W. -S., Hutchison, T., Kellar, J., Kilerci-Eser, E., Kim, S., King, A. L., La Mura, G., Laney, C. D., Li, M., Lochhaas, C., Ma, Z., MacInnis, F., Manne-Nicholas, E. R., Mason, M., McGraw, S. M., Mogren, K., Montouri, C., Moody, J. W., Mosquera, A. M., Mudd, D., Musso, R., Nazarov, S. V., Nguyen, M. L., Ochner, P., Okhmat, D. N., Onken, C. A., Ou-Yang, B., Pancoast, A., Pei, L., Penny, M., Poleski, R., Portaluri, E., Prieto, J. -L., Price-Whelan, A. M., Pulatova, N. G., Rafter, S., Roettenbacher, R. M., Romero-Colmenero, E., Runnoe, J., Schimoia, J. S., Shappee, B. J., Sherf, N., Simonian, G. V., Siviero, A., Skowron, D. M., Skowron, J., Somers, G., Spencer, M., Starkey, D. A., Stevens, D. J., Stoll, R., Tamajo, E., Tayar, J., van Saders, J. L., Valenti, S., Villanueva, Jr., S., Villforth, C., Weiss, Y., Winkler, H., Zastrow, J., Zhu, W., and Zu, Y.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present the first results from a reverberation-mapping campaign undertaken during the first half of 2012, with additional data on one AGN (NGC 3227) from a 2014 campaign. Our main goals are (1) to determine the black hole masses from continuum-Hbeta reverberation signatures, and (2) to look for velocity-dependent time delays that might be indicators of the gross kinematics of the broad-line region. We successfully measure Hbeta time delays and black hole masses for five AGNs, four of which have previous reverberation mass measurements. The values measured here are in agreement with earlier estimates, though there is some intrinsic scatter beyond the formal measurement errors. We observe velocity dependent Hbeta lags in each case, and find that the patterns have changed in the intervening five years for three AGNs that were also observed in 2007., Comment: Accepted for publication on ApJ; 32 pages, 16 figures, 10 tables
Published: 2018
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3. Continuum Reverberation Mapping of the Accretion Disks in Two Seyfert 1 Galaxies

Author: Fausnaugh, M. M., Starkey, D. A., Horne, Keith, Kochanek, C. S., Peterson, B. M., Bentz, M. C., Denney, K. D., Grier, C. J., Grupe, D., Pogge, R. W., DeRosa, G., Adams, S. M., Barth, A. J., Beatty, Thomas G., Bhattacharjee, A., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brown, Jacob E., Brown, Jonathan S., Brotherton, M. S., Coker, C. T., Crawford, S. M., Croxall, K. V., Eftekharzadeh, Sarah, Eracleous, Michael, Joner, M. D., Henderson, C. B., Holoien, T. W. -S., Hutchison, T., Kaspi, Shai, Kim, S., King, Anthea L., Li, Miao, Lochhaas, Cassandra, Ma, Zhiyuan, MacInnis, F., Manne-Nicholas, E. R., Mason, M., Montuori, Carmen, Mosquera, Ana, Mudd, Dale, Musso, R., Nazarov, S. V., Nguyen, M. L., Okhmat, D. N., Onken, ChristopherA., Ou-Yang, B., Pancoast, A., Pei, L., Penny, Matthew T., Poleski, Radosław, Rafter, Stephen, Romero-Colmenero, E., Runnoe, Jessie, Sand, David J., Schimoia, Jaderson S., Sergeev, S. G., Shappee, B. J., Simonian, Gregory V., Somers, Garrett, Spencer, M., Stevens, Daniel J., Tayar, Jamie, Treu, T., Valenti, Stefano, VanSaders, J., VillanuevaJr., S., Villforth, C., Weiss, Yaniv, Winkler, H., and Zhu, W.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present optical continuum lags for two Seyfert 1 galaxies, MCG+08-11-011 and NGC 2617, using monitoring data from a reverberation mapping campaign carried out in 2014. Our light curves span the ugriz filters over four months, with median cadences of 1.0 and 0.6 days for MCG+08-11-011 and NGC\,2617, respectively, combined with roughly daily X-ray and near-UV data from Swift for NGC 2617. We find lags consistent with geometrically thin accretion-disk models that predict a lag-wavelength relation of $\tau \propto \lambda^{4/3}$. However, the observed lags are larger than predictions based on standard thin-disk theory by factors of 3.3 for MCG+08-11-011 and 2.3 for NGC\,2617. These differences can be explained if the mass accretion rates are larger than inferred from the optical luminosity by a factor of 4.3 in MCG+08-11-011 and a factor of 1.3 in NGC\,2617, although uncertainty in the SMBH masses determines the significance of this result. While the X-ray variability in NGC\,2617 precedes the UV/optical variability, the long 2.6 day lag is problematic for coronal reprocessing models., Comment: Accepted to ApJ, please send comments to faus@mit.edu. 24 pages, 8 figures
Published: 2018
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4. Space Telescope and Optical Reverberation Mapping Project. VII. Understanding the UV anomaly in NGC 5548 with X-Ray Spectroscopy

Author: Mathur, S., Gupta, A., Page, K., Pogge, R. W., Krongold, Y., Goad, M. R., Adams, S. M., Anderson, M. D., Arevalo, P., Barth, A. J., Bazhaw, C., Beatty, T. G., Bentz, M. C., Bigley, A., Bisogni, S., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brown, J. E., Brown, J. S., Cackett, E. M., Canalizo, G., Carini, M. T., Clubb, K. I., Comerford, J. M., Coker, C. T., Corsini, E. M., Crenshaw, D. M., Croft, S., Croxall, K. V., Bonta, E. Dalla, Deason, A. J., Denney, K. D., De Lorenzo-Caceres, A., De Rosa, G., Dietrich, M., Edelson, R., Ely, J., Eracleous, M., Evans, P. A., Fausnaugh, M. M., Ferland, G. J., Filippenko, A. V., Flatland, K., Fox, O. D., Gates, E. L., Gehrels, N., Geier, S., Gelbord, J. M., Gorjian, V., Greene, J. E., Grier, C. J., Grupe, D., Hall, P. B., Henderson, C. B., Hicks, S., Holmbeck, E., Holoien, T. W. -S., Horenstein, D., Horne, Keith, Hutchison, T., Im, M., Jensen, J. J., Johnson, C. A., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, B. C., Kelly, P. L., Kennea, J. A., Kim, M., Kim, S., Kim, S. C., King, A., Klimanov, S. A., Kochanek, C. S., Korista, K. T., Kriss, G. A., Lau, M. W., Lee, J. C., Leonard, D. C., Li, M., Lira, P., Ma, Z., MacInnis, F., Manne-Nicholas, E. R., Malkan, M. A., Mauerhan, J. C., McGurk, R., McHardy, I. M., Montouri, C., Morelli, L., Mosquera, A., Mudd, D., Muller-Sanchez, F., Musso, R., Nazarov, S. V., Netzer, H., Nguyen, M. L., Norris, R. P., Nousek, J. A., Ochner, P., Okhmat, D. N., Ou-Yang, B., Pancoast, A., Papadakis, I., Parks, J. R., Pei, L., Peterson, B. M., Pizzella, A., Poleski, R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Runnoe, J., Saylor, D. A., Schimoia, J. S., Schnülle, K., Sergeev, S. G., Shappee, B. J., Shivvers, I., Siegel, M., Simonian, G. V., Siviero, A., Skielboe, A., Somers, G., Spencer, M., Starkey, D., Stevens, D. J., Sung, H. -I., Tayar, J., Tejos, N., Turner, C. S., Uttley, P., Van Saders, J., Vestergaard, M., Vican, L., VillanuevaJr., S., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Yuk, H., Zheng, W., Zhu, W., and Zu, Y.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: During the Space Telescope and Optical Reverberation Mapping Project (STORM) observations of NGC 5548, the continuum and emission-line variability became de-correlated during the second half of the 6-month long observing campaign. Here we present Swift and Chandra X-ray spectra of NGC 5548 obtained as a part of the campaign. The Swift spectra show that excess flux (relative to a power-law continuum) in the soft X-ray band appears before the start of the anomalous emission-line behavior, peaks during the period of the anomaly, and then declines. This is a model-independent result suggesting that the soft excess is related to the anomaly. We divide the Swift data into on- and off-anomaly spectra to characterize the soft excess via spectral fitting. The cause of the spectral differences is likely due to a change in the intrinsic spectrum rather than being due to variable obscuration or partial covering. The Chandra spectra have lower signal-to-noise ratios, but are consistent with Swift data. Our preferred model of the soft excess is emission from an optically thick, warm Comptonizing corona, the effective optical depth of which increases during the anomaly. This model simultaneously explains all the three observations: the UV emission line flux decrease, the soft-excess increase, and the emission line anomaly., Comment: ApJ in press. Replaced with the accepted version
Published: 2017
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5. Space Telescope and Optical Reverberation Mapping Project. V. Optical Spectroscopic Campaign and Emission-Line Analysis for NGC 5548

Author: Pei, L., Fausnaugh, M. M., Barth, A. J., Peterson, B. M., Bentz, M. C., De Rosa, G., Denney, K. D., Goad, M. R., Kochanek, C. S., Korista, K. T., Kriss, G. A., Pogge, R. W., Bennert, V. N., Brotherton, M., Clubb, K. I., Bontà, E. Dalla, Filippenko, A. V., Greene, J. E., Grier, C. J., Vestergaard, M., Zheng, W., Adams, Scott M., Beatty, Thomas G., Bigley, A., Brown, Jacob E., Brown, Jonathan S., Canalizo, G., Comerford, J. M., Coker, Carl T., Corsini, E. M., Croft, S., Croxall, K. V., Deason, A. J., Eracleous, Michael, Fox, O. D., Gates, E. L., Henderson, C. B., Holmbeck, E., Holoien, T. W. -S., Jensen, J. J., Johnson, C. A., Kelly, P. L., Kim, S., King, A., Lau, M. W., Li, Miao, Lochhaas, Cassandra, Ma, Zhiyuan, Manne-Nicholas, E. R., Mauerhan, J. C., Malkan, M. A., McGurk, R., Morelli, L., Mosquera, Ana, Mudd, Dale, Sanchez, F. Muller, Nguyen, M. L., Ochner, P., Ou-Yang, B., Pancoast, A., Penny, Matthew T., Pizzella, A., Poleski, Radosław, Runnoe, Jessie, Scott, B., Schimoia, Jaderson S., Shappee, B. J., Shivvers, I., Simonian, Gregory V., Siviero, A., Somers, Garrett, Stevens, Daniel J., Strauss, M. A., Tayar, Jamie, Tejos, N., Treu, T., Van Saders, J., Vican, L., Villanueva Jr., S., Yuk, H., Zakamska, N. L., Zhu, W., Anderson, M. D., Arévalo, P., Bazhaw, C., Bisogni, S., Borman, G. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Cackett, E. M., Carini, M. T., Crenshaw, D. M., De Lorenzo-Cáceres, A., Dietrich, M., Edelson, R., Efimova, N. V., Ely, J., Evans, P. A., Ferland, G. J., Flatland, K., Gehrels, N., Geier, S., Gelbord, J. M., Grupe, D., Gupta, A., Hall, P. B., Hicks, S., Horenstein, D., Horne, Keith, Hutchison, T., Im, M., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, B. C., Kennea, J. A., Kim, M., Kim, S. C., Klimanov, S. A., Lee, J. C., Leonard, D. C., Lira, P., MacInnis, F., Mathur, S., McHardy, I. M., Montouri, C., Musso, R., Nazarov, S. V., Netzer, H., Norris, R. P., Nousek, J. A., Okhmat, D. N., Papadakis, I., Parks, J. R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Saylor, D. A., Schnülle, K., Sergeev, S. G., Siegel, M., Skielboe, A., Spencer, M., Starkey, D., Sung, H. -I., Teems, K. G., Turner, C. S., Uttley, P., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., and Zu, Y.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present the results of an optical spectroscopic monitoring program targeting NGC 5548 as part of a larger multi-wavelength reverberation mapping campaign. The campaign spanned six months and achieved an almost daily cadence with observations from five ground-based telescopes. The H$\beta$ and He II $\lambda$4686 broad emission-line light curves lag that of the 5100 $\AA$ optical continuum by $4.17^{+0.36}_{-0.36}$ days and $0.79^{+0.35}_{-0.34}$ days, respectively. The H$\beta$ lag relative to the 1158 $\AA$ ultraviolet continuum light curve measured by the Hubble Space Telescope is roughly $\sim$50% longer than that measured against the optical continuum, and the lag difference is consistent with the observed lag between the optical and ultraviolet continua. This suggests that the characteristic radius of the broad-line region is $\sim$50% larger than the value inferred from optical data alone. We also measured velocity-resolved emission-line lags for H$\beta$ and found a complex velocity-lag structure with shorter lags in the line wings, indicative of a broad-line region dominated by Keplerian motion. The responses of both the H$\beta$ and He II $\lambda$4686 emission lines to the driving continuum changed significantly halfway through the campaign, a phenomenon also observed for C IV, Ly $\alpha$, He II(+O III]), and Si IV(+O IV]) during the same monitoring period. Finally, given the optical luminosity of NGC 5548 during our campaign, the measured H$\beta$ lag is a factor of five shorter than the expected value implied by the $R_\mathrm{BLR} - L_\mathrm{AGN}$ relation based on the past behavior of NGC 5548., Comment: 22 pages, 13 figures, accepted to ApJ
Published: 2017
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6. Space Telescope and Optical Reverberation Mapping Project VI: reverberating Disk Models for NGC 5548

Author: Starkey, D., Horne, Keith, Fausnaugh, M. M., Peterson, B. M., Bentz, M. C., Kochanek, C. S., Denney, K. D., Edelson, R., Goad, M. R., De Rosa, G., Anderson, M. D., Arevalo, P., Barth, A. J., Bazhaw, C., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Cackett, E. M., Carini, M. T., Croxall, K. V., Crenshaw, D. M., Bonta, E. Dalla, De Lorenzo-Caceres, A., Dietrich, M., Efimova, N. V., Ely, J., Evans, P. A., Filippenko, A. V., Flatland, K., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Grier, C. J., Grupe, D., Hall, P. B., Hicks, S., Horenstein, D., Hutchison, T., Im, M., Jensen, J. J., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, B. C., Kennea, J. A., Kim, S. C., Kim, M., Klimanov, S. A., Korista, K. T., Kriss, G. A., Lee, J. C., Leonard, D. C., Lira, P., MacInnis, F., Manne-Nicholas, E. R., Mathur, S., McHardy, I. M., Montouri, C., Musso, R., Nazarov, S. V., Norris, R. P., Nousek, J. A., Okhmat, D. N., Pancoast, A., Parks, J. R., Pei, L., Pogge, R. W., Pott, J. -U., Rafter, S. E., Rix, H. W., Saylor, D. A., Schimoia, J. S., Schnulle, K., Sergeev, S. G., Siegel, M. H., Spencer, M., Sung, H. -I., Teems, K. G., Turner, C. S., Uttley, P., Vestergaard, M., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., Zheng, W., and Zu, Y.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We conduct a multiwavelength continuum variability study of the Seyfert 1 galaxy NGC 5548 to investigate the temperature structure of its accretion disk. The 19 overlapping continuum light curves (1158 to 9157 angstroms) combine simultaneous HST , Swift , and ground-based observations over a 180 day period from 2014 January to July. Light-curve variability is interpreted as the reverberation response of the accretion disk to irradiation by a central time-varying point source. Our model yields the disk inclination, i, temperature T1 at 1 light day from the black hole, and a temperature-radius slope, alpha. We also infer the driving light curve and find that it correlates poorly with both the hard and soft X-ray light curves, suggesting that the X-rays alone may not drive the ultraviolet and optical variability over the observing period. We also decompose the light curves into bright, faint, and mean accretion-disk spectra. These spectra lie below that expected for a standard blackbody accretion disk accreting at L/LEdd = 0.1, Comment: V2: Oops wrong title! V1: Accepted for publication in ApJ, 20 Pages, 11 Figures
Published: 2016
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7. Velocity-resolved Reverberation Mapping of Five Bright Seyfert 1 Galaxies

Author: De Rosa, G, Fausnaugh, MM, Grier, CJ, Peterson, BM, Denney, KD, Horne, Keith, Bentz, MC, Ciroi, S, Bontà, E Dalla, Joner, MD, Kaspi, S, Kochanek, CS, Pogge, RW, Sergeev, SG, Vestergaard, M, Adams, SM, Antognini, J, Salvo, C Araya, Armstrong, E, Bae, J, Barth, AJ, Beatty, TG, Bhattacharjee, A, Borman, GA, Boroson, TA, Bottorff, MC, Brown, JE, Brown, JS, Brotherton, MS, Coker, CT, Clanton, C, Cracco, V, Crawford, SM, Croxall, KV, Eftekharzadeh, S, Eracleous, M, Fiorenza, SL, Frassati, A, Hawkins, K, Henderson, CB, Holoien, TW-S, Hutchison, T, Kellar, J, Kilerci-Eser, E, Kim, S, King, AL, La Mura, G, Laney, CD, Li, M, Lochhaas, C, Ma, Z, MacInnis, F, Manne-Nicholas, ER, Mason, M, McGraw, SM, Mogren, K, Montouri, C, Moody, JW, Mosquera, AM, Mudd, D, Musso, R, Nazarov, SV, Nguyen, ML, Ochner, P, Okhmat, DN, Onken, CA, Ou-Yang, B, Pancoast, A, Pei, L, Penny, M, Poleski, R, Portaluri, E, Prieto, J-L, Price-Whelan, AM, Pulatova, NG, Rafter, S, Roettenbacher, RM, Romero-Colmenero, E, Runnoe, J, Schimoia, JS, Shappee, BJ, Sherf, N, Simonian, GV, Siviero, A, Skowron, DM, Skowron, J, Somers, G, Spencer, M, Starkey, DA, Stevens, DJ, Stoll, R, Tamajo, E, Tayar, J, van Saders, JL, Valenti, S, Villanueva, S, Villforth, C, Weiss, Y, Winkler, H, and Zastrow, J
Subjects: galaxies: active, galaxies: nuclei, galaxies: Seyfert, astro-ph.GA, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: We present the first results from a reverberation-mapping campaign undertaken during the first half of 2012, with additional data on one active galactic nucleus (AGN) (NGC 3227) from a 2014 campaign. Our main goals are (1) to determine the black hole masses from continuum-Hβ reverberation signatures, and (2) to look for velocity-dependent time delays that might be indicators of the gross kinematics of the broad-line region. We successfully measure Hβ time delays and black hole masses for five AGNs, four of which have previous reverberation mass measurements. The values measured here are in agreement with earlier estimates, though there is some intrinsic scatter beyond the formal measurement errors. We observe velocity-dependent Hβ lags in each case, and find that the patterns have changed in the intervening five years for three AGNs that were also observed in 2007.
Published: 2018

8. Continuum Reverberation Mapping of the Accretion Disks in Two Seyfert 1 Galaxies

Author: Fausnaugh, MM, Starkey, DA, Horne, Keith, Kochanek, CS, Peterson, BM, Bentz, MC, Denney, KD, Grier, CJ, Grupe, D, Pogge, RW, De Rosa, G, Adams, SM, Barth, AJ, Beatty, Thomas G, Bhattacharjee, A, Borman, GA, Boroson, TA, Bottorff, MC, Brown, Jacob E, Brown, Jonathan S, Brotherton, MS, Coker, CT, Crawford, SM, Croxall, KV, Eftekharzadeh, Sarah, Eracleous, Michael, Joner, MD, Henderson, CB, Holoien, TW-S, Hutchison, T, Kaspi, Shai, Kim, S, King, Anthea L, Li, Miao, Lochhaas, Cassandra, Ma, Zhiyuan, MacInnis, F, Manne-Nicholas, ER, Mason, M, Montuori, Carmen, Mosquera, Ana, Mudd, Dale, Musso, R, Nazarov, SV, Nguyen, ML, Okhmat, DN, Onken, Christopher A, Ou-Yang, B, Pancoast, A, Pei, L, Penny, Matthew T, Poleski, Radosław, Rafter, Stephen, Romero-Colmenero, E, Runnoe, Jessie, Sand, David J, Schimoia, Jaderson S, Sergeev, SG, Shappee, BJ, Simonian, Gregory V, Somers, Garrett, Spencer, M, Stevens, Daniel J, Tayar, Jamie, Treu, T, Valenti, Stefano, Van Saders, J, Villanueva, S, Villforth, C, Weiss, Yaniv, Winkler, H, and Zhu, W
Subjects: accretion, accretion disks, galaxies: individual, galaxies: Seyfert, astro-ph.GA, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: We present optical continuum lags for two Seyfert 1 galaxies, MCG+08-11-011 and NGC 2617, using monitoring data from a reverberation mapping campaign carried out in 2014. Our light curves span the ugriz filters over four months, with median cadences of 1.0 and 0.6 days for MCG+08-11-011 and NGC 2617, respectively, combined with roughly daily X-ray and near-UV data from Swift for NGC 2617. We find lags consistent with geometrically thin accretion-disk models that predict a lag-wavelength relation of τ ∝ λ 4/3. However, the observed lags are larger than predictions based on standard thin-disk theory by factors of 3.3 for MCG+08-11-011 and 2.3 for NGC 2617. These differences can be explained if the mass accretion rates are larger than inferred from the optical luminosity by a factor of 4.3 in MCG+08-11-011 and a factor of 1.3 in NGC 2617, although uncertainty in the SMBH masses determines the significance of this result. While the X-ray variability in NGC 2617 precedes the UV/optical variability, the long (2.6 day) lag is problematic for coronal reprocessing models.
Published: 2018

9. Reverberation Mapping of Optical Emission Lines in Five Active Galaxies

Author: Fausnaugh, M. M., Grier, C. J., Bentz, M. C., Denney, K. D., De Rosa, G., Peterson, B. M., Kochanek, C. S., Pogge, R. W., Adams, S. M., Barth, A. J., Beatty, Thomas G., Bhattacharjee, A., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brown, Jacob E., Brown, Jonathan S., Brotherton, M. S., Coker, C. T., Crawford, S. M., Croxall, K. V., Eftekharzadeh, Sarah, Eracleous, Michael, Joner, M. D., Henderson, C. B., Holoien, T. W. -S., Horne, Keith, Hutchison, T., Kaspi, Shai, Kim, S., King, Anthea L., Li, Miao, Lochhaas, Cassandra, Ma, Zhiyuan, MacInnis, F., Manne-Nicholas, E. R., Mason, M., Montuori, Carmen, Mosquera, Ana, Mudd, Dale, Musso, R., Nazarov, S. V., Nguyen, M. L., Okhmat, D. N., Onken, Christopher A., Ou-Yang, B., Pancoast, A., Pei, L., Penny, Matthew T., Poleski, Radoslaw, Rafter, Stephen, Romero-Colmenero, E., Runnoe, Jessie, Sand, David J., Schimoia, Jaderson S., Sergeev, S. G., Shappee, B. J., Simonian, Gregory V., Somers, Garrett, Spencer, M., Starkey, D., Stevens, Daniel J., Tayar, Jamie, Treu, T., Valenti, Stefano, Van Saders, J., Villanueva Jr., S., Villforth, C., Weiss, Yaniv, Winkler, H., and Zhu, W.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present the first results from an optical reverberation mapping campaign executed in 2014, targeting the active galactic nuclei (AGN) MCG+08-11-011, NGC 2617, NGC 4051, 3C 382, and Mrk 374. Our targets have diverse and interesting observational properties, including a "changing look" AGN and a broad-line radio galaxy. Based on continuum-H$\beta$ lags, we measure black hole masses for all five targets. We also obtain H$\gamma$ and He{\sc ii}\,$\lambda 4686$ lags for all objects except 3C 382. The He{\sc ii}\,$\lambda 4686$ lags indicate radial stratification of the BLR, and the masses derived from different emission lines are in general agreement. The relative responsivities of these lines are also in qualitative agreement with photoionization models. These spectra have extremely high signal-to-noise ratios (100--300 per pixel) and there are excellent prospects for obtaining velocity-resolved reverberation signatures., Comment: 34 pages, 12 figures, published in ApJ. For a video summarizing the main results, see https://www.youtube.com/watch?v=KaC-jPsIY0Q
Published: 2016
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10. Space Telescope and Optical Reverberation Mapping Project. IV. Anomalous behavior of the broad ultraviolet emission lines in NGC 5548

Author: Goad, M. R., Korista, K. T., De Rosa, G., Kriss, G. A., Edelson, R., Barth, A. J., Ferland, G. J., Kochanek, C. S., Netzer, H., Peterson, B. M., Bentz, M. C., Bisogni, S., Crenshaw, D. M., Denney, K. D., Ely, J., Fausnaugh, M. M., Grier, C. J., Gupta, A., Horne, K. D., Kaastra, J., Pancoast, A., Pei, L., Pogge, R. W., Skielboe, A., Starkey, D., Vestergaard, M., Zu, Y., Anderson, M. D., Arevalo, P., Bazhaw, C., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Brewer, B. J., Cackett, E. M., Carini, M. T., Croxall, K. V., Bonta, E. Dalla, de Lorenzo-Caceres, A., Dietrich, M., Efimova, N. V., Evans, P. A., Filippenko, A. V., Flatland, K., Gehrels, N., Geier, S., Gelbord, G. M., Gonzalez, L., Gorjian, V., Grupe, D., Hall, P. B., Hicks, S., Horenstein, D., Hutchison, T., Im, M., Jensen, J. J., Joner, M. D., Jones, J., Kaspi, S., Kelly, B. C., Kennea, J. A., Kim, M., Kim, S. C., Klimanov, S. A., Larionov, V. M., Lee, J. C., Leonard, D. C., Lira, P., MacInnis, F., Manne-Nicholas, E. R., Mathur, S., McHardy, I. M., Montouri, C., Musso, R., Nazarov, S. V., Norris, R. P., Nousek, J. A., Okhmat, D. N., Papadakis, I., Parks, J. R., Pott, J. -U., Rafter, S. E., Rix, H. -W., Saylor, D. A., Schimoia, J. S., Schnulle, K., Sergeev, S. G., Siegel, M., Spencer, M., Sung, H. -I., Teems, K. G., Treu, T., Turner, C. S., Uttley, P., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., Young, S., and Zheng, W. -K.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: During an intensive Hubble Space Telescope (HST) Cosmic Origins Spectrograph (COS) UV monitoring campaign of the Seyfert~1 galaxy NGC 5548 performed from 2014 February to July, the normally highly correlated far-UV continuum and broad emission-line variations decorrelated for ~60 to 70 days, starting ~75 days after the first HST/COS observation. Following this anomalous state, the flux and variability of the broad emission lines returned to a more normal state. This transient behavior, characterised by significant deficits in flux and equivalent width of the strong broad UV emission lines, is the first of its kind to be unambiguously identified in an active galactic nucleus reverberation mapping campaign. The largest corresponding emission-line flux deficits occurred for the high-ionization collisionally excited lines, C IV and Si IV(+O IV]), and also He II(+O III]), while the anomaly in Ly-alpha was substantially smaller. This pattern of behavior indicates a depletion in the flux of photons with E_{\rm ph} > 54 eV, relative to those near 13.6 eV. We suggest two plausible mechanisms for the observed behavior: (i) temporary obscuration of the ionizing continuum incident upon BLR clouds by a moving veil of material lying between the inner accretion disk and inner BLR, perhaps resulting from an episodic ejection of material from the disk, or (ii) a temporary change in the intrinsic ionizing continuum spectral energy distribution resulting in a deficit of ionizing photons with energies > 54 eV, possibly due to a transient restructuring of the Comptonizing atmosphere above the disk. Current evidence appears to favor the latter explanation., Comment: 12 pages, 2 figures, accepted for publication in ApJ, Friday 25th March 2016. A movie of the anomalous emission-line behavior can be found in the ancilliary documents
Published: 2016
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11. Space Telescope and Optical Reverberation Mapping Project. VII. Understanding the Ultraviolet Anomaly in NGC 5548 with X-Ray Spectroscopy

Author: Mathur, S, Gupta, A, Page, K, Pogge, RW, Krongold, Y, Goad, MR, Adams, SM, Anderson, MD, Arévalo, P, Barth, AJ, Bazhaw, C, Beatty, TG, Bentz, MC, Bigley, A, Bisogni, S, Borman, GA, Boroson, TA, Bottorff, MC, Brandt, WN, Breeveld, AA, Brown, JE, Brown, JS, Cackett, EM, Canalizo, G, Carini, MT, Clubb, KI, Comerford, JM, Coker, CT, Corsini, EM, Crenshaw, DM, Croft, S, Croxall, KV, Bontà, E Dalla, Deason, AJ, Denney, KD, De Lorenzo-Cáceres, A, De Rosa, G, Dietrich, M, Edelson, R, Ely, J, Eracleous, M, Evans, PA, Fausnaugh, MM, Ferland, GJ, Filippenko, AV, Flatland, K, Fox, OD, Gates, EL, Gehrels, N, Geier, S, Gelbord, JM, Gorjian, V, Greene, JE, Grier, CJ, Grupe, D, Hall, PB, Henderson, CB, Hicks, S, Holmbeck, E, Holoien, TW-S, Horenstein, D, Horne, Keith, Hutchison, T, Im, M, Jensen, JJ, Johnson, CA, Joner, MD, Jones, J, Kaastra, J, Kaspi, S, Kelly, BC, Kelly, PL, Kennea, JA, Kim, M, Kim, S, Kim, SC, King, A, Klimanov, SA, Kochanek, CS, Korista, KT, Kriss, GA, Lau, MW, Lee, JC, Leonard, DC, Li, M, Lira, P, Ma, Z, MacInnis, F, Manne-Nicholas, ER, Malkan, MA, Mauerhan, JC, McGurk, R, McHardy, IM, Montouri, C, Morelli, L, Mosquera, A, Mudd, D, Muller-Sanchez, F, Musso, R, and Nazarov, SV
Subjects: galaxies: active, galaxies: individual, X-rays: galaxies, X-rays: individual, astro-ph.GA, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: During the Space Telescope and Optical Reverberation Mapping Project observations of NGC 5548, the continuum and emission-line variability became decorrelated during the second half of the six-month-long observing campaign. Here we present Swift and Chandra X-ray spectra of NGC 5548 obtained as part of the campaign. The Swift spectra show that excess flux (relative to a power-law continuum) in the soft X-ray band appears before the start of the anomalous emission-line behavior, peaks during the period of the anomaly, and then declines. This is a model-independent result suggesting that the soft excess is related to the anomaly. We divide the Swift data into on- and off-anomaly spectra to characterize the soft excess via spectral fitting. The cause of the spectral differences is likely due to a change in the intrinsic spectrum rather than to variable obscuration or partial covering. The Chandra spectra have lower signal-to-noise ratios, but are consistent with the Swift data. Our preferred model of the soft excess is emission from an optically thick, warm Comptonizing corona, the effective optical depth of which increases during the anomaly. This model simultaneously explains all three observations: the UV emission-line flux decrease, the soft-excess increase, and the emission-line anomaly.
Published: 2017

12. Reverberation Mapping of Optical Emission Lines in Five Active Galaxies

Author: Fausnaugh, MM, Grier, CJ, Bentz, MC, Denney, KD, De Rosa, G, Peterson, BM, Kochanek, CS, Pogge, RW, Adams, SM, Barth, AJ, Beatty, Thomas G, Bhattacharjee, A, Borman, GA, Boroson, TA, Bottorff, MC, Brown, Jacob E, Brown, Jonathan S, Brotherton, MS, Coker, CT, Crawford, SM, Croxall, KV, Eftekharzadeh, Sarah, Eracleous, Michael, Joner, MD, Henderson, CB, Holoien, TW-S, Horne, Keith, Hutchison, T, Kaspi, Shai, Kim, S, King, Anthea L, Li, Miao, Lochhaas, Cassandra, Ma, Zhiyuan, MacInnis, F, Manne-Nicholas, ER, Mason, M, Montuori, Carmen, Mosquera, Ana, Mudd, Dale, Musso, R, Nazarov, SV, Nguyen, ML, Okhmat, DN, Onken, Christopher A, Ou-Yang, B, Pancoast, A, Pei, L, Penny, Matthew T, Poleski, Radosław, Rafter, Stephen, Romero-Colmenero, E, Runnoe, Jessie, Sand, David J, Schimoia, Jaderson S, Sergeev, SG, Shappee, BJ, Simonian, Gregory V, Somers, Garrett, Spencer, M, Starkey, DA, Stevens, Daniel J, Tayar, Jamie, Treu, T, Valenti, Stefano, Van Saders, J, Villanueva, S, Villforth, C, Weiss, Yaniv, Winkler, H, and Zhu, W
Subjects: galaxies: active, galaxies: individual, astro-ph.GA, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: We present the first results from an optical reverberation mapping campaign executed in 2014 targeting the active galactic nuclei (AGNs) MCG+08-11-011, NGC 2617, NGC 4051, 3C 382, and Mrk 374. Our targets have diverse and interesting observational properties, including a "changing look" AGN and a broad-line radio galaxy. Based on continuum-Hβ lags, we measure black hole masses for all five targets. We also obtain Hγ and He ii λ4686 lags for all objects except 3C 382. The He ii λ4686 lags indicate radial stratification of the BLR, and the masses derived from different emission lines are in general agreement. The relative responsivities of these lines are also in qualitative agreement with photoionization models. These spectra have extremely high signal-to-noise ratios (100-300 per pixel) and there are excellent prospects for obtaining velocity-resolved reverberation signatures.
Published: 2017

13. SPACE TELESCOPE AND OPTICAL REVERBERATION MAPPING PROJECT.VI. REVERBERATING DISK MODELS FOR NGC 5548

Author: Starkey, D, Horne, Keith, Fausnaugh, MM, Peterson, BM, Bentz, MC, Kochanek, CS, Denney, KD, Edelson, R, Goad, MR, De Rosa, G, Anderson, MD, Arévalo, P, Barth, AJ, Bazhaw, C, Borman, GA, Boroson, TA, Bottorff, MC, Brandt, WN, Breeveld, AA, Cackett, EM, Carini, MT, Croxall, KV, Crenshaw, DM, Bontà, E Dalla, De Lorenzo-Cáceres, A, Dietrich, M, Efimova, NV, Ely, J, Evans, PA, Filippenko, AV, Flatland, K, Gehrels, N, Geier, S, Gelbord, JM, Gonzalez, L, Gorjian, V, Grier, CJ, Grupe, D, Hall, PB, Hicks, S, Horenstein, D, Hutchison, T, Im, M, Jensen, JJ, Joner, MD, Jones, J, Kaastra, J, Kaspi, S, Kelly, BC, Kennea, JA, Kim, SC, Kim, M, Klimanov, SA, Korista, KT, Kriss, GA, Lee, JC, Leonard, DC, Lira, P, MacInnis, F, Manne-Nicholas, ER, Mathur, S, McHardy, IM, Montouri, C, Musso, R, Nazarov, SV, Norris, RP, Nousek, JA, Okhmat, DN, Pancoast, A, Parks, JR, Pei, L, Pogge, RW, Pott, J-U, Rafter, SE, Rix, H-W, Saylor, DA, Schimoia, JS, Schnülle, K, Sergeev, SG, Siegel, MH, Spencer, M, Sung, H-I, Teems, KG, Turner, CS, Uttley, P, Vestergaard, M, Villforth, C, Weiss, Y, Woo, J-H, Yan, H, Young, and S, Zheng, W, and Zu, Y
Subjects: accretion, accretion disks, galaxies: active, galaxies: individual, galaxies: nuclei, galaxies: Seyfert, astro-ph.GA, astro-ph.HE, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: We conduct a multiwavelength continuum variability study of the Seyfert 1 galaxy NGC 5548 to investigate the temperature structure of its accretion disk. The 19 overlapping continuum light curves (1158 A oto 9157 A o) combine simultaneous Hubble Space Telescope, Swift, and ground-based observations over a 180 day period from 2014 January to July. Light-curve variability is interpreted as the reverberation response of the accretion disk to irradiation by a central time-varying point source. Our model yields the disk inclination i = 36° ±10° temperature T1 = 44 ±6 ) × 10 3 K at 1 light day from the black hole, and a temperatureradius slope (T ∞r-a) of a = 0.99 ±0.03. We also infer the driving light curve and find that it correlates poorly with both the hard and soft X-ray light curves, suggesting that the X-rays alone may not drive the ultraviolet and optical variability over the observing period. We also decompose the light curves into bright, faint, and mean accretion-disk spectra. These spectra lie below that expected for a standard blackbody accretion disk accreting at L LEdd = 0.1.
Published: 2017

14. Space Telescope and Optical Reverberation Mapping Project. III. Optical Continuum Emission and Broad-Band Time Delays in NGC 5548

Author: Fausnaugh, M. M., Denney, K. D., Barth, A. J., Bentz, M. C., Bottorff, M. C., Carini, M. T., Croxall, K. V., De Rosa, G., Goad, M. R., Horne, Keith, Joner, M. D., Kaspi, S., Kim, M., Klimanov, S. A., Kochanek, C. S., Leonard, D. C., Netzer, H., Peterson, B. M., Schnulle, K., Sergeev, S. G., Vestergaard, M., Zheng, W. -K., Zu, Y., Anderson, M. D., Arevalo, P., Bazhaw, C., Borman, G. A., Boroson, T. A., Brandt, W. N., Breeveld, A. A., Brewer, B. J., Cackett, E. M., Crenshaw, D. M., Bonta, E. Dalla, De Lorenzo-Caceres, A., Dietrich, M., Edelson, R., Efimova, N. V., Ely, J., Evans, P. A., Filippenko, A. V., Flatland, K., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Grier, C. J., Grupe, D., Hall, P. B., Hicks, S., Horenstein, D., Hutchison, T., Im, M., Jensen, J. J., Jones, J., Kaastra, J., Kelly, B. C., Kennea, J. A., Kim, S. C., Korista, K. T., Kriss, G. A., Lee, J. C., Lira, P., MacInnis, F., Manne-Nicholas, E. R., Mathur, S., McHardy, I. M., Montouri, C., Musso, R., Nazarov, S. V., Norris, R. P., Nousek, J. A., Okhmat, D. N., Pancoast, A., Papadakis, I., Parks, J. R., Pei, L., Pogge, R. W., Pott, J. -U., Rafter, S. E., Rix, H. -W., Saylor, D. A., Schimoia, J. S., Siegel, M., Spencer, M., Starkey, D., Sung, H. -I., Teems, K. G., Treu, T., Turner, C. S., Uttley, P., Villforth, C., Weiss, Y., Woo, J. -H., Yan, H., and Young, S.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present ground-based optical photometric monitoring data for NGC 5548, part of an extended multi-wavelength reverberation mapping campaign. The light curves have nearly daily cadence from 2014 January to July in nine filters (\emph{BVRI} and \emph{ugriz}). Combined with ultraviolet data from the \emph{Hubble Space Telescope} and \emph{Swift}, we confirm significant time delays between the continuum bands as a function of wavelength, extending the wavelength coverage from 1158\,\AA\ to the $z$ band ($\sim\!9160$\,\AA). We find that the lags at wavelengths longer than the {\it V} band are equal to or greater than the lags of high-ionization-state emission lines (such as He\,{\sc ii}\,$\lambda 1640$ and $\lambda 4686$), suggesting that the continuum-emitting source is of a physical size comparable to the inner broad-line region (BLR). The trend of lag with wavelength is broadly consistent with the prediction for continuum reprocessing by an accretion disk with $\tau \propto \lambda^{4/3}$. However, the lags also imply a disk radius that is 3 times larger than the prediction from standard thin-disk theory, assuming that the bolometric luminosity is 10\% of the Eddington luminosity ($L = 0.1L_{\rm Edd}$). Using optical spectra from the Large Binocular Telescope, we estimate the bias of the interband continuum lags due to BLR emission observed in the filters. We find that the bias for filters with high levels of BLR contamination ($\sim\! 20\%$) can be important for the shortest continuum lags, and likely has a significant impact on the {\it u} and {\it U} bands owing to Balmer continuum emission., Comment: 26 pages, 10 figures, accepted to ApJ. For a brief video describing the main results of this paper, please see: https://www.youtube.com/watch?v=yaYtcDvIoP0&feature=youtu.be
Published: 2015
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15. SPACE TELESCOPE AND OPTICAL REVERBERATION MAPPING PROJECT. IV. ANOMALOUS BEHAVIOR OF THE BROAD ULTRAVIOLET EMISSION LINES IN NGC 5548

Author: Goad, MR, Korista, KT, De Rosa, G, Kriss, GA, Edelson, R, Barth, AJ, Ferland, GJ, Kochanek, CS, Netzer, H, Peterson, BM, Bentz, MC, Bisogni, S, Crenshaw, DM, Denney, KD, Ely, J, Fausnaugh, MM, Grier, CJ, Gupta, A, Horne, KD, Kaastra, J, Pancoast, A, Pei, L, Pogge, RW, Skielboe, A, Starkey, D, Vestergaard, M, Zu, Y, Anderson, MD, Arévalo, P, Bazhaw, C, Borman, GA, Boroson, TA, Bottorff, MC, Brandt, WN, Breeveld, AA, Brewer, BJ, Cackett, EM, Carini, MT, Croxall, KV, Bontà, E Dalla, De Lorenzo-Cáceres, A, Dietrich, M, Efimova, NV, Evans, PA, Filippenko, AV, Flatland, K, Gehrels, N, Geier, S, Gelbord, JM, Gonzalez, L, Gorjian, V, Grupe, D, Hall, PB, Hicks, S, Horenstein, D, Hutchison, T, Im, M, Jensen, JJ, Joner, MD, Jones, J, Kaspi, S, Kelly, BC, Kennea, JA, Kim, M, Kim, SC, Klimanov, SA, Lee, JC, Leonard, DC, Lira, P, MacInnis, F, Manne-Nicholas, ER, Mathur, S, McHardy, IM, Montouri, C, Musso, R, Nazarov, SV, Norris, RP, Nousek, JA, Okhmat, DN, Papadakis, I, Parks, JR, Pott, J-U, Rafter, SE, Rix, H-W, Saylor, DA, Schimoia, JS, Schnülle, K, Sergeev, SG, Siegel, M, Spencer, M, Sung, H-I, Teems, KG, Treu, T, Turner, CS, Uttley, P, Villforth, C, Weiss, Y, Woo, J-H, Yan, H, and Young, S
Subjects: galaxies: active, galaxies: individual, galaxies: nuclei, galaxies: Seyfert, astro-ph.GA, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: During an intensive Hubble Space Telescope (HST) Cosmic Origins Spectrograph (COS) UV monitoring campaign of the Seyfert 1 galaxy NGC 5548 performed from 2014 February to July, the normally highly correlated far UV continuum and broad emission line variations decorrelated for ∼60-70 days, starting ∼75 days after the first HST/COS observation. Following this anomalous state, the flux and variability of the broad emission lines returned to a more normal state. This transient behavior, characterized by significant deficits in flux and equivalent width of the strong broad UV emission lines, is the first of its kind to be unambiguously identified in an active galactic nucleus reverberation mapping campaign. The largest corresponding emission line flux deficits occurred for the high ionization, collisionally excited lines C iv and Si iv(+O iv]), and also He ii(+O iii]), while the anomaly in Lywas substantially smaller. This pattern of behavior indicates a depletion in the flux of photons with relative to those near 13.6 eV. We suggest two plausible mechanisms for the observed behavior: (i) temporary obscuration of the ionizing continuum incident upon broad line region (BLR) clouds by a moving veil of material lying between the inner accretion disk and inner (BLR), perhaps resulting from an episodic ejection of material from the disk, or (ii) a temporary change in the intrinsic ionizing continuum spectral energy distribution resulting in a deficit of ionizing photons with energies >54 eV, possibly due to a transient restructuring of the Comptonizing atmosphere above the disk. Current evidence appears to favor the latter explanation.
Published: 2016

16. SPACE TELESCOPE AND OPTICAL REVERBERATION MAPPING PROJECT. III. OPTICAL CONTINUUM EMISSION AND BROADBAND TIME DELAYS IN NGC 5548

Author: Fausnaugh, MM, Denney, KD, Barth, AJ, Bentz, MC, Bottorff, MC, Carini, MT, Croxall, KV, De Rosa, G, Goad, MR, Horne, Keith, Joner, MD, Kaspi, S, Kim, M, Klimanov, SA, Kochanek, CS, Leonard, DC, Netzer, H, Peterson, BM, Schnülle, K, Sergeev, SG, Vestergaard, M, Zheng, W-K, Zu, Y, Anderson, MD, Arévalo, P, Bazhaw, C, Borman, GA, Boroson, TA, Brandt, WN, Breeveld, AA, Brewer, BJ, Cackett, EM, Crenshaw, DM, Bontà, E Dalla, De Lorenzo-Cáceres, A, Dietrich, M, Edelson, R, Efimova, NV, Ely, J, Evans, PA, Filippenko, AV, Flatland, K, Gehrels, N, Geier, S, Gelbord, JM, Gonzalez, L, Gorjian, V, Grier, CJ, Grupe, D, Hall, PB, Hicks, S, Horenstein, D, Hutchison, T, Im, M, Jensen, JJ, Jones, J, Kaastra, J, Kelly, BC, Kennea, JA, Kim, SC, Korista, KT, Kriss, GA, Lee, JC, Lira, P, MacInnis, F, Manne-Nicholas, ER, Mathur, S, McHardy, IM, Montouri, C, Musso, R, Nazarov, SV, Norris, RP, Nousek, JA, Okhmat, DN, Pancoast, A, Papadakis, I, Parks, JR, Pei, L, Pogge, RW, Pott, J-U, Rafter, SE, Rix, H-W, Saylor, DA, Schimoia, JS, Siegel, M, Spencer, M, Starkey, D, Sung, H-I, Teems, KG, Treu, T, Turner, CS, Uttley, P, Villforth, C, Weiss, Y, Woo, J-H, Yan, H, and Young, S
Subjects: galaxies: active, galaxies: individual, galaxies: nuclei, galaxies: Seyfert, astro-ph.GA, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract: We present ground-based optical photometric monitoring data for NGC 5548, part of an extended multiwavelength reverberation mapping campaign. The light curves have nearly daily cadence from 2014 January to July in nine filters (BVRI and ugriz). Combined with ultraviolet data from the Hubble Space Telescope and Swift, we confirm significant time delays between the continuum bands as a function of wavelength, extending the wavelength coverage from 1158 Å to the z band (∼9160 Å). We find that the lags at wavelengths longer than the V band are equal to or greater than the lags of high-ionization-state emission lines (such as He ii and λ1640 and λ4686), suggesting that the continuum-emitting source is of a physical size comparable to the inner broad-line region (BLR). The trend of lag with wavelength is broadly consistent with the prediction for continuum reprocessing by an accretion disk with τ ∝ λ 4 . However, the lags also imply a disk radius that is 3 times larger than the prediction from standard thin-disk theory, assuming that the bolometric luminosity is 10% of the Eddington luminosity (L = 0.1 L Edd ). Using optical spectra from the Large Binocular Telescope, we estimate the bias of the interband continuum lags due to BLR emission observed in the filters. We find that the bias for filters with high levels of BLR contamination (∼20%) can be important for the shortest continuum lags and likely has a significant impact on the u and U bands owing to Balmer continuum emission.
Published: 2016

17. Primary productivity and animal local density covary in a partially migratory wild guanaco population

Author: Marozzi, A., Panebianco, A., Gomez, F.M., Gonzalez Musso, R., Gregorio, P.F., Schroeder, N., Moreno, P., Peña, F., and Carmanchahi, P.D.
Published: 2024
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18. Space Telescope and Optical Reverberation Mapping Project. VI. Reverberating Disk Models for NGS 5548

Author: Starkey, D, Gehrels, Cornelis, Horne, Keith, Fausnaugh, M. M, Peterson, B. M, Bentz, M. C, Kochanek, C. S, Denney, K. D, Edelson, R, Goad, M. R, De Rosa, G, Anderson, M. D, Arevalo, P, Barth, A. J, Bazhaw, C, Borman, G. A, Boroson, T. A, Bottorff, M. C, Brandt, W. N, Breeveld, A. A, Cackett E. M, Carini, M. T, Croxall, K. V, Crenshaw, D. M, Dalla Bonta, E, De Lorenzo-Caceres, A, Dietrich, M, Efimova, N. V, Ely, J, Evans, P. A, Filippenko, A. V, Flatland, I, Gehrels, N, Geier, S, Gelbord, J. M, Gonzalez, L, Gorjian, V, Grier, C. J, Grupe, D, Hall, P. B, Hicks, S, Horenstein, D, Hutchison, T, Im, M, Jensen, J. J, Joner, M. D, Jones, J, Kaastra, J, Kaspi, S, Kelly, B. C, Kennea, J. A, Kim, S. C, Kim, M, Kilmanov, S. A, Korista, K. T, Kriss, G. A, Lee, J. C, Leonard, D. C, Lira, P, MacInnis, F, Manne-Nicholas, E. R, Mathur, S, McHardy, I. M, Montouri, C, Musso, R, Nazarov, S. V, Norris, R. P, Nousek, J. A, Okhmat, D. N, Pancoast, A, Parks, J. R, Pei, L, Pogge, R. W, Pott, J.-U, Rafter, S. E, Rix, H.-W, Saylor, D. A, Schimoia, J. S, Schnuelle, K, Sergeev, S. G, Siegel, M. H, Spencer, M, Sung, H. I, Teems, K. G, Turner, C. S, Uttley, P, Vestergaard, M, Villforth, C, Weiss, Y, Woo, J.-H, Yan, H, Young, S, Zheng, W, and Zu, Y
Subjects: Astrophysics
Abstract: We conduct a multi-wavelength continuum variability study of the Seyfert 1 galaxy NGC 5548 to investigate the temperature structure of its accretion disk. The 19 overlapping continuum light curves (1158 Angstrom to 9157 Angstrom) combine simultaneous Hubble Space Telescope, Swift, and ground-based observations over a 180 day period from 2014 January to July. Light-curve variability is interpreted as the reverberation response of the accretion disk to irradiation by a central time-varying point source. Our model yields the disk inclination i = 36deg +/- 10deg, temperature T(sub 1) = (44+/-6) times 10 (exp 3)K at 1 light day from the black hole, and a temperature radius slope (T proportional to r (exp -alpha)) of alpha = 0.99 +/- 0.03. We also infer the driving light curve and find that it correlates poorly with both the hard and soft X-ray light curves, suggesting that the X-rays alone may not drive the ultraviolet and optical variability over the observing period. We also decompose the light curves into bright, faint, and mean accretion-disk spectra. These spectra lie below that expected for a standard blackbody accretion disk accreting at L/L(sub Edd) = 0.1.
Published: 2017
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19. Using an Unmanned Air Vehicle (UAV) as a forest health monitoring method in coniferous plantations in Northern Patagonia, Argentina

Author: González Musso, R. F., Rabino, A. L., and Azzaro, F.
Subjects: VANT, Sanidad forestal, Sirex noctilio, Patagonia Argentina, UAV, Plantaciones forestales, Forest plantations, Forest health, Argentine Patagonia
Abstract: Resumen Las plantaciones forestales proveen múltiples beneficios económicos, sociales y ambientales pero su rendimiento puede verse amenazado por la aparición de plagas. Contar con métodos eficientes de monitoreo es de importancia para implementar mecanismos de control y seguimiento. En los últimos años los Vehículos Aéreos No Tripulados (VANTs) han posibilitado la adquisición de información de gran resolución espacio - temporal para el estudio de procesos ecológicos y forestales. Sus características únicas los convierten en potenciales herramientas de monitoreo sanitario en plantaciones forestales. A pesar de ello, en Argentina existen pocas experiencias documentadas sobre su aplicación en el monitoreo de plagas. En este trabajo se analizó el uso de un VANT como método de monitoreo y cuantificación del daño ocasionado por Sirex noctilio en forestaciones de coníferas. Particularmente se evaluó la capacidad de estimar los niveles de infestación y de generar productos cartográficos que contribuyan al análisis de la dinámica poblacional de la plaga. Las estimaciones logradas con el VANT fueron comparadas con los métodos de campo utilizados habitualmente en la región. Los resultados obtenidos han sido satisfactorios: el VANT permitió identificar a escala de árbol la sintomatología y cuantificar los niveles de daño. Las estimaciones mostraron una tendencia a subestimar en forma sesgada y con valores acep-tables. Asimismo, se obtuvieron productos espacialmente explícitos sobre la distribución de la plaga, permitiendo localizar pequeños focos o incluso individuos aislados sobre la superficie relevada. Los resultados de este trabajo sugieren que los VANTs pueden contribuir en generar mejores estrategias de manejo y control de plagas forestales en la región. Abstract Forest plantations provide a wide range of economic, social and environmental benefits in many parts of the world but their productivity could be affected by the presence of pests. Counting on efficient monitoring and surveying methods is important to help controlling and mitigating impacts caused by pathogens. Last years, Unmanned Air Vehicles (UAVs), commonly known as drones, have made it possible obtaining high space-time resolution information for studying ecological and forest processes. They have become potential tools for forest health studies due to their unique features. However, there is little knowledge about its performance concerning forest health monitoring in Argentina. This study analyzed the potential use of UAVs for forest health monitoring and damage estimation in coniferous plantation stands including Sirex noctilio. Particularly, the capacity for quantifying infestation levels and mapping distribution was tested. The UAVs estimations were compared to those obtained from traditional field survey methods used in this region. The results were satisfactory and promising. UAVs allowed to detect symptomatology at tree level and quantify infestation. Estimates showed a tendency to underestimate in a sly manner and with acceptable values, which could be statistically adjustable in the future. In addition, spatially explicit products were generated upon plague distribution which allowed for the detection of small infection spots and of isolated trees with visible symptoms. The results of this study suggest that UAVs may become key instruments for health surveying that contribute to efficient management and control of forest pests and diseases in Patagonia.
Published: 2020

20. Breast cancer cells treated with proton beam: Immunological features and gene signatures

Author: Cammarata F. P., Bravata V., Minafra L., Pisciotta P., Musso R., Pucci G., Scazzone C., Manti L., Militello C., Petringa G., Cirrone G. A. P., Cuttone G., Gilardi M. C., Russo G., Forte G. I., Cammarata, F, Bravata, V, Minafra, L, Pisciotta, P, Musso, R, Pucci, G, Scazzone, C, Manti, L, Militello, C, Petringa, G, Cirrone, G, Cuttone, G, Gilardi, M, Russo, G, Forte, G, Cammarata, F. P., Bravata, V., Minafra, L., Pisciotta, P., Musso, R., Pucci, G., Scazzone, C., Manti, L., Militello, C., Petringa, G., Cirrone, G. A. P., Cuttone, G., Gilardi, M. C., Russo, G., and Forte, G. I.
Subjects: proton beam, Immunological features, Breast cancer cell
Abstract: The breast cancer (BC) disease is characterized by a wide heterogeneity at both clinical and molecular level, showing distinct subtypes with different clinical outcomes. Thus, the choice of the therapeutic plan, such as the type of radiotherapy (RT) need to take into account this complexity. Indeed, the proton therapy (PT) shows a medical benefit compared to conventional X-ray RT, as regards the localized delivery of the radiation dose sparing health tissues, but few data regarding proton-induced molecular changes are currently available. The aim of this study was therefore to investigate the production of immunological molecules and gene expression profiles induced by proton irradiation on BC cell lines. Clonogenic survival assay, luminex assay and cDNA microarray gene expression analyses were performed both in the non-tumorigenic MCF10A cell line and in two tumorigenic MCF7 and MDA-MB-231 cell lines, following irradiation with 0.5, 2 and 9 Gy of clinical proton beams. We found that proton irradiation induced gene expression changes useful to define a cell line and dose-dependent gene signatures. The lack of molecular data in the literature can be filled by data here presented that could represent a useful tool to better understand the molecular mechanisms elicited by protons predicting the treatment outcome.
Published: 2018

21. Breast cancer cells treated with proton beam: Immunological features and gene signatures

Author: Cammarata, F, Bravata, V, Minafra, L, Pisciotta, P, Musso, R, Pucci, G, Scazzone, C, Manti, L, Militello, C, Petringa, G, Cirrone, G, Cuttone, G, Gilardi, M, Russo, G, Forte, G, Cammarata F. P., Bravata V., Minafra L., Pisciotta P., Musso R., Pucci G., Scazzone C., Manti L., Militello C., Petringa G., Cirrone G. A. P., Cuttone G., Gilardi M. C., Russo G., Forte G. I., Cammarata, F, Bravata, V, Minafra, L, Pisciotta, P, Musso, R, Pucci, G, Scazzone, C, Manti, L, Militello, C, Petringa, G, Cirrone, G, Cuttone, G, Gilardi, M, Russo, G, Forte, G, Cammarata F. P., Bravata V., Minafra L., Pisciotta P., Musso R., Pucci G., Scazzone C., Manti L., Militello C., Petringa G., Cirrone G. A. P., Cuttone G., Gilardi M. C., Russo G., and Forte G. I.
Abstract: The breast cancer (BC) disease is characterized by a wide heterogeneity at both clinical and molecular level, showing distinct subtypes with different clinical outcomes. Thus, the choice of the therapeutic plan, such as the type of radiotherapy (RT) need to take into account this complexity. Indeed, the proton therapy (PT) shows a medical benefit compared to conventional X-ray RT, as regards the localized delivery of the radiation dose sparing health tissues, but few data regarding proton-induced molecular changes are currently available. The aim of this study was therefore to investigate the production of immunological molecules and gene expression profiles induced by proton irradiation on BC cell lines. Clonogenic survival assay, luminex assay and cDNA microarray gene expression analyses were performed both in the non-tumorigenic MCF10A cell line and in two tumorigenic MCF7 and MDA-MB-231 cell lines, following irradiation with 0.5, 2 and 9 Gy of clinical proton beams. We found that proton irradiation induced gene expression changes useful to define a cell line and dose-dependent gene signatures. The lack of molecular data in the literature can be filled by data here presented that could represent a useful tool to better understand the molecular mechanisms elicited by protons predicting the treatment outcome.
Published: 2018

22. The role of leptin in the etiopathogenesis of anorexia nervosa and bulimia

Author: Calandra, C., Musso, F., and Musso, R.
Published: 2003
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23. Haemostatic abnormalities and lupus anticoagulant activity in patients with Gaucher disease type I

Author: Barone, R., Giuffrida, G., Musso, R., Carpinteri, G., and Fiumara, A.
Published: 2000
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24. A prospective registry of European haemophilia B patients receiving nonacog alfa, recombinant human factor IX, for usual use

Author: BERNTORP, E., KEELING, D., MAKRIS, M., TAGLIAFERRI, A., MALE, C., MAUSER-BUNSCHOTEN, E. P., MUSSO, R., ROCA, C. A., HASSOUN, A., KOLLMER, C., CHARNIGO, R., BAUMANN, J., and RENDO, P.
Published: 2012
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25. A retrospective study to describe the incidence of moderate to severe allergic reactions to factor IX in subjects with haemophilia B

Author: RECHT, M., POLLMANN, H., TAGLIAFERRI, A., MUSSO, R., JANCO, R., and NEUMAN, RICHEY W.
Published: 2011
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26. Efficacy and safety of highly purified, doubly virus-inactivated VWF/FVIII concentrates in inherited von Willebrandʼs disease: results of an Italian cohort study on 120 patients characterized by bleeding severity score

Author: FEDERICI, A. B., BARILLARI, G., ZANON, E., MAZZUCCONI, M. G., MUSSO, R., TARGHETTA, R., and MANNUCCI, P. M.
Published: 2010
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27. Postmarketing surveillance study of KOGENATE® Bayer with Bio-Set® in patients with haemophilia A: evaluation of patients’ satisfaction after switch to the new reconstitution system

Author: VIDOVIC, N., MUSSO, R., KLAMROTH, R., ENRIQUEZ, M. M., and ACHILLES, K.
Published: 2010
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28. Factor VIII gene (F8) mutations as a predictor of outcome in immune tolerance induction (ITI) in hemophilia A patients with high-responding inhibitors: OC-TU-075

Author: Coppola, A, Margaglione, M, Santagostino, E, Rocino, A, Scaraggi, F, Tagliaferri, A, Castaman, G, Messina, M, Mancuso, M E, Iorio, A, Schinco, P, Zanon, E, Musso, R, Mancuso, G, Di Minno, G, and Mannucci, P
Published: 2009
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29. Intracranial haemorrhage in haemophilia A and B: an italian retrospective survey: AS-TU-032

Author: Zanon, E, Spiezia, L, Santagostino, E, Coppola, A, Tagliaferri, A, Rossetti, G, Iorio, A, Santoro, R, Dragani, A, Giuffrida, A, Musso, R, Mancuso, G, Castaman, G, Gamba, G, Mazzucconi, G, and Lapecorella, M
Published: 2009
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30. Immune tolerance induction with a high purity von Willebrand factor/VIII complex concentrate in haemophilia A patients with inhibitors at high risk of a poor response

Author: GRINGERI, A., MUSSO, R., MAZZUCCONI, M. G., PISEDDU, G., SCHIAVONI, M., PIGNOLONI, P., and MANNUCCI, P. M.
Published: 2007

31. Safety, Efficacity and Cost-effectiveness of regular prophylaxis with Refacto® in adults with severe hemophilia A: a prospective study: 28 PO 875

Author: GRINGERI, A, MONZINI, M, RAVERA, S, SANTORO, C, MUSSO, R, and MANTOVANI, L
Published: 2006

32. Post-marketing surveillance study of KOGENATE® Bayer (Kogenate® FS) in 202 patients with severe hemophilia A: 05 PO 110

Author: MUSSO, R, DEN BERG, M VAN, SANTAGOSTINO, E, FARADJI, A, MAAS-ENRIQUEZ, M, HAUPT, V, and GORINA, E
Published: 2006

33. Clinical efficacy of highly purified, doubly virus-inactivated factor VIII/von Willebrand factor concentrate (Fanhdi®) in the treatment of von Willebrand disease: a retrospective clinical study

Author: FEDERICI, A. B., BAUDO, F., CARACCIOLO, C., MANCUSO, G., MAZZUCCONI, M. G., MUSSO, R., SCHINCO, P. C., TARGHETTA, R., and MANNUCCI, P. MANNUCCIO
Published: 2002

34. Molecular genotyping of patients with severe haemophilia and inhibitors

Author: SALVIATO, R, BELVINI, D, MANCUSO, G, SCARAGGI, A, MUSSO, R, MULEO, G, BERRETTINI, M, LOMBARDO, V TRAPANI, TAMPONI, G, and TAGARIELLO, G
Published: 2002

35. Acquired haemophilia associated with myelodysplastic syndrome successfully treated with oral immunosuppressive therapy

Author: GIUFFRIDA, G, FERLITO, C, CIPOLLA, A, MUSSO, R, and GIUSTOLISI, R
Published: 2002

36. MULTIOMICS ANALYSIS OF S100 PROTEINS IN BREAST CANCER

Author: CANCEMI, Patrizia, Albanese, NN, Di Cara, G, Musso, R, Lupo,C, Roz, E, FEO, Salvatore, Pucci Minafra,I, Cancemi, P, Albanese, NN, Di Cara, G, Musso, R, Lupo,C, Roz, E, Feo,S, and Pucci-Minafra,I.
Subjects: Settore BIO/06 - Anatomia Comparata E Citologia, S100 proteins
Abstract: The S100 gene family is the largest subfamily of calcium binding proteins of EF-hand type, expressed in tissue and cell-specific manner. S100 proteins act as intracellular regulators and as extracellular signaling. Within cells, S100 have been involved in the regulation of proliferation, differentiation, apoptosis, energy metabolism, inflammation, migration and invasion via interactions with a variety of target proteins. Extracellular S100 proteins act in an autocrine and paracrine manner through the activation of surface receptors that regulate cell proliferation, differentiation, survival and migration. More recently, there is growing interest in the S100 proteins and their relationship with different cancers because of their involvement in a variety of biological events closely related to tumorigenesis and cancer progression1. However, the occurrence, the role and the possible coordination of this group of proteins in breast cancer is still poorly known. We previously describe a large-scale proteomic investigation performed on breast cancer patients for the screening of multiple forms of S100 proteins2,3. Our results have shown that the majority of S100 proteins are preferentially expressed in the tumor mass compared with the normal adjacent tissue and that some S100 protein members were ubiquitously expressed in almost all patients, while others appeared more sporadic among the same group of patients. More interestingly, patients which developed distant metastases showed a general tendency of higher S100 protein expression, compared to the disease-free group. Present study was aimed to assess the gene expression levels of the S100 protein family members utilizing a breast cancer dataset generated on Affymetrix microarrays technologies4. GOBO (Gene expression-based Outcome for Breast cancer Online) is a user-friendly online tool that allows, also, the identification of co-expressed genes and association with outcome in an 1881 breast cancer samples. Other important association with breast cancer outome was carried out by Kaplan Meir-plotter database5. Integrating results obtained by proteomic and trascriptomic analysis of S100 proteins highlight their important involvement in breast cancer progression, and support the idea that S100 proteins are important prognostic factors, related to survival period of tumor patients. However, the specific mechanisms by which S100 proteins affect progression of breast require further study.
Published: 2015

37. COMPARATIVE PROFILING BY PROTEOMICS AND ZYMOGRAPHIC ACTIVITIES OF TUMORAL AND NON TUMORAL CELL LINES

Author: Musso, R, Di Cara, G, ALBANESE, Nadia Ninfa, CANCEMI, Patrizia, Martini, D, GIORDANO, Carla, Pucci Minafra, I., Musso, R, Di Cara, G, Albanese, NN, Cancemi, P, Martini, D, Giordano, C, and Pucci-Minafra, I
Subjects: ECM, Settore BIO/06 - Anatomia Comparata E Citologia, Settore MED/13 - Endocrinologia
Abstract: The extracellular matrix (ECM) underlying epithelial tissues is involved in the maintenance of cell polarity and homeostasis. ECM is a dynamic structure under the regulated remodeling of its components. The major enzymes responsible of matrix degradation are the matrix metalloproteinases (MMPs), a well known family of zinc-dependent endopeptidases. Much attention has been focused on MMP-2 and MMP-9 because of their ability to degrade type IV collagen, a major constituent of basement membranes. A deregulated proteolysis of ECM molecules may cause the alteration of cell polarity and may contribute to the disruption of cell–cell and cell–ECM adhesions, promoting cancer progression. These alterations are responsible for a poor prognosis, and a positive correlation between the increase of MMPs and the degree of malignancy has also been observed FOR many tumor histotypes. To approach these issues on in vitro models, we performed a comparative study, between a couple of tumoral and non-tumoral mammary cell lines and a couple of thyroid cell lines derived respectively from a benign and malignant cancer. This experimental approach, based on scanning electron microscopy, on proteomic analysis and on gelatin zimography, highlighted a similar profiling of the two differential couples of cell lines: that is between malignant and non-malignant cells respectively, regardless of their histological origin. In particular, it was observed that the cell lines derived from aggressive cancers, when compared with their non-malignant counterpart, showed an increased secretion of MMPs, a cell shape highly pleomorphic and a higher expression of protein clusters potentially associated with invasion and metastasis. The analysis of the interactions between the expression of MMPs and of selected proteomic clusters have offered important indication on the complex network existing between neoplastic cells and their environment. The work was co-funded by the Italian 5x1000 to COBS.
Published: 2015

38. NEW PROTEOMIC EVIDENCE ON DECORIN EFFECTS ON BREAST CANCER CELLS

Author: DI CARA, G, PUCCI MINAFRA, I, CANCEMI, Patrizia, MUSSO, R, MINAFRA, S., DI CARA, G, PUCCI-MINAFRA, I, CANCEMI, P, MUSSO, R, and MINAFRA, S.
Subjects: DECORIN, PROTEOMICS
Abstract: The estabilishment of a dinamic crosstyalk between the malignant cells and several components of the ECM is a crucial step of the tumor progression. The aim of the present study was to improve the knowledge about the effects of ectopic decorin on the breast cancer cells, starting from our previous proteomic studies. The new proteomic evidences strenghteh the anti-oncogenic effects of decorin and hilight the attention on the decreased expression of the majority of the members of three protein classes closely related to the malignant phenotype: the metabolic enzymes, the S100 family and the cell motility proteins
Published: 2015

39. S100PROTEINS IN BREAST CANCER: MULTIOMICS-BASED ANALYSIS

Author: CANCEMI, Patrizia, ALBANESE, NN, DI CARA, G, MUSSO, R, CONTINO, Flavia, FEO, Salvatore, PUCCI MINAFRA,I, CANCEMI, P, ALBANESE, NN, DI CARA, G, MUSSO, R, CONTINO, F, FEO, S, and PUCCI-MINAFRA,I.
Subjects: S100 PROTEINS, BREAST CANCER
Abstract: S100 gene family is the largest subfamily of calcium binding proteins, expressed in tissue and cell-specific manner. Within cells, S100 have been involved in the regulation of proliferation, differentiation, apoptosis, energy metabolism, inflammation, migration and invasion. Extracellular S100 proteins act in an autocrine and paracrine manner and regulate cell proliferation, differentiation, survival and migration. S100 proteins play important roles in the development and progression of tumors due to their multifunctional roles. However, the occurrence, the role and the possible coordination of this group of proteins in breast cancer is still poorly known. We previously describe a large-scale proteomic investigation performed on breast cancer patients for the screening of multiple forms of S100 proteins1,2. Our results have shown that the majority of S100 proteins are preferentially expressed in the tumor mass compared with the normal adjacent tissue and that some S100 protein members were ubiquitously expressed in almost all patients, while others appeared more sporadic among the same group of patients. More interestingly, patients which developed distant metastases showed a general tendency of higher S100 protein expression, compared to the disease-free group. Present study was aimed to assess the gene expression levels of the S100 protein family members utilizing a breast cancer dataset generated on Affymetrix microarrays technologies3. GOBO (Gene expression-based Outcome for Breast cancer Online) is a user-friendly online tool that allows, also, the identification of co-expressed genes and association with outcome in an 1881 breast cancer samples. Other important association with breast cancer outome was carried out by Kaplan Meir-plotter database4. Integrating results obtained by proteomic and trascriptomic analysis of S100 proteins highlight their important involvement in breast cancer progression. Future studies are needed to disclose molecular mechanisms and signaling pathways that define the multiple and specific roles of S100 proteins in breast cancer.
Published: 2015

40. TA treatment of depression : a hermeneutic single-case\ud efficacy design study - ‘Caterina’

Author: Benelli, E, Filanti, S, Musso, R, Calvo, V, Mannarini, S, Palmieri, A, and Widdowson, MDJ
Abstract: This study is the second of a series of seven, and\ud belongs to the second Italian systematic replication of\ud findings from two previous series (Widdowson 2012a,\ud 2012b, 2012c, 2013; Benelli, 2016a, 2016b, 2016c) that\ud investigated the effectiveness of a manualised\ud transactional analysis treatment for depression through\ud Hermeneutic Single-Case Efficacy Design. The therapist\ud was a white Italian woman with 10 years of clinical\ud experience and the client, Caterina, was a 28-year old\ud white Italian woman who attended 16 sessions of\ud transactional analysis psychotherapy. Caterina satisfied\ud DSM-5 criteria for major depressive disorder with\ud generalized anxiety disorder. The conclusion of the\ud judges was that this was an outstanding good-outcome\ud case: the depressive symptoms showed an early clinical\ud and reliable improvement, maintained till the 6 months\ud follow-up, accompanied by reductions in anxiety\ud symptoms, global distress and severity of personal\ud problems. Adherence to the manualised treatment for\ud depression appears good to excellent. In this case study,\ud transactional analysis treatment for depression has\ud proven its efficacy in treating major depressive disorder\ud in comorbidity with anxiety disorder.
Published: 2017

41. DIFFERENTIAL INFLUENCE OF HYPOXIA ON GENE EXPRESSION OF TUMORAL AND NON TUMORAL MAMMARY CELLS

Author: Albanese, N., DI CARA, G., Musso, R., Cancemi, P., Filippi, I., Carraro, F., PUCCI MINAFRA, I., ALBANESE, NN, DI CARA, G, MUSSO, R, CANCEMI, P, FILIPPI, I, CARRARO, F, and PUCCI-MINAFRA, I.
Subjects: HYPOXIA, BREAST CANCER
Abstract: Cancer metastasis is the result of a series of deregulated biological phenomena, including alterations of cell-cell and cell-matrix interactions and of other microenvironmental conditions such as the oxygen tissue supply. Hypoxia is a well-known driver of aggressive cancer phenotypes, indeed tumors with poor prognosis have higher proportions of anoxic and hypoxic areas1. The consequences of tumour hypoxia can be local or even systemic towards distant organs, and it can evoke diversified responses: whereas low oxygen concentration in tissue environments. (pO2
Published: 2015

42. SPACE TELESCOPE AND OPTICAL REVERBERATION MAPPING PROJECT. VI. REVERBERATING DISK MODELS FOR NGC 5548

Author: Starkey, D., Horne, Keith, Fausnaugh, M. M., Peterson, B. M., Bentz, M. C., Kochanek, C. S., Denney, K. D., Edelson, R., Goad, M. R., De Rosa, G., Anderson, M. D., Arevalo, P., Barth, A. J., Bazhaw, C., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Cackett, E. M., Carini, M. T., Croxall, K. V., Crenshaw, D. M., Dalla Bonta, E., De Lorenzo-Caceres, A., Dietrich, M., Efimova, N. V., Ely, J., Evans, P. A., Filippenko, A. V., Flatland, K., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Grier, C. J., Grupe, D., Hall, P. B., Hicks, S., Horenstein, D., Hutchison, T., Im, M., Jensen, J. J., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, B. C., Kennea, J. A., Kim, S. C., Kim, M., Klimanov, S. A., Korista, K. T., Kriss, G. A., Lee, J. C., Leonard, D. C., Lira, P., MacInnis, F., Manne-Nicholas, E. R., Mathur, S., McHardy, I. M., Montouri, C., Musso, R., Nazarov, S. V., Norris, R. P., Nousek, J. A., Okhmat, D. N., Pancoast, A., Parks, J. R., Pei, L., Pogge, R. W., Pott, J-U, Rafter, S. E., Rix, H-W, Saylor, D. A., Schimoia, J. S., Schnuelle, K., Sergeev, S. G., Siegel, M. H., Spencer, M., Sung, H-I, Teems, K. G., Turner, C. S., Uttley, P., Vestergaard, M., Villforth, C., Weiss, Y., Woo, J-H, Yan, H., Young, S., Zheng, W., Zu, Y., Starkey, D., Horne, Keith, Fausnaugh, M. M., Peterson, B. M., Bentz, M. C., Kochanek, C. S., Denney, K. D., Edelson, R., Goad, M. R., De Rosa, G., Anderson, M. D., Arevalo, P., Barth, A. J., Bazhaw, C., Borman, G. A., Boroson, T. A., Bottorff, M. C., Brandt, W. N., Breeveld, A. A., Cackett, E. M., Carini, M. T., Croxall, K. V., Crenshaw, D. M., Dalla Bonta, E., De Lorenzo-Caceres, A., Dietrich, M., Efimova, N. V., Ely, J., Evans, P. A., Filippenko, A. V., Flatland, K., Gehrels, N., Geier, S., Gelbord, J. M., Gonzalez, L., Gorjian, V., Grier, C. J., Grupe, D., Hall, P. B., Hicks, S., Horenstein, D., Hutchison, T., Im, M., Jensen, J. J., Joner, M. D., Jones, J., Kaastra, J., Kaspi, S., Kelly, B. C., Kennea, J. A., Kim, S. C., Kim, M., Klimanov, S. A., Korista, K. T., Kriss, G. A., Lee, J. C., Leonard, D. C., Lira, P., MacInnis, F., Manne-Nicholas, E. R., Mathur, S., McHardy, I. M., Montouri, C., Musso, R., Nazarov, S. V., Norris, R. P., Nousek, J. A., Okhmat, D. N., Pancoast, A., Parks, J. R., Pei, L., Pogge, R. W., Pott, J-U, Rafter, S. E., Rix, H-W, Saylor, D. A., Schimoia, J. S., Schnuelle, K., Sergeev, S. G., Siegel, M. H., Spencer, M., Sung, H-I, Teems, K. G., Turner, C. S., Uttley, P., Vestergaard, M., Villforth, C., Weiss, Y., Woo, J-H, Yan, H., Young, S., Zheng, W., and Zu, Y.
Published: 2017

43. The Correlation Between Fatty Acids and Platelet Function

Author: Cacciola, E., Musso, R., Giustolisi, R., Catania, N. M., Cacciola, R. R., Zichichi, Antonino, editor, Cajozzo, A., editor, Perricone, R., editor, Di Marco, P., editor, and Palazzolo, P., editor
Published: 1985
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44. Space Telescope and Optical Reverberation Mapping Project. V. Optical Spectroscopic Campaign and Emission-line Analysis for NGC 5548

Author: Pei, L., primary, Fausnaugh, M. M., additional, Barth, A. J., additional, Peterson, B. M., additional, Bentz, M. C., additional, De Rosa, G., additional, Denney, K. D., additional, Goad, M. R., additional, Kochanek, C. S., additional, Korista, K. T., additional, Kriss, G. A., additional, Pogge, R. W., additional, Bennert, V. N., additional, Brotherton, M., additional, Clubb, K. I., additional, Dalla Bontà, E., additional, Filippenko, A. V., additional, Greene, J. E., additional, Grier, C. J., additional, Vestergaard, M., additional, Zheng, W., additional, Adams, Scott M., additional, Beatty, Thomas G., additional, Bigley, A., additional, Brown, Jacob E., additional, Brown, Jonathan S., additional, Canalizo, G., additional, Comerford, J. M., additional, Coker, Carl T., additional, Corsini, E. M., additional, Croft, S., additional, Croxall, K. V., additional, Deason, A. J., additional, Eracleous, Michael, additional, Fox, O. D., additional, Gates, E. L., additional, Henderson, C. B., additional, Holmbeck, E., additional, Holoien, T. W.-S., additional, Jensen, J. J., additional, Johnson, C. A., additional, Kelly, P. L., additional, Kim, S., additional, King, A., additional, Lau, M. W., additional, Li, Miao, additional, Lochhaas, Cassandra, additional, Ma, Zhiyuan, additional, Manne-Nicholas, E. R., additional, Mauerhan, J. C., additional, Malkan, M. A., additional, McGurk, R., additional, Morelli, L., additional, Mosquera, Ana, additional, Mudd, Dale, additional, Sanchez, F. Muller, additional, Nguyen, M. L., additional, Ochner, P., additional, Ou-Yang, B., additional, Pancoast, A., additional, Penny, Matthew T., additional, Pizzella, A., additional, Poleski, Radosław, additional, Runnoe, Jessie, additional, Scott, B., additional, Schimoia, Jaderson S., additional, Shappee, B. J., additional, Shivvers, I., additional, Simonian, Gregory V., additional, Siviero, A., additional, Somers, Garrett, additional, Stevens, Daniel J., additional, Strauss, M. A., additional, Tayar, Jamie, additional, Tejos, N., additional, Treu, T., additional, Van Saders, J., additional, Vican, L., additional, Villanueva, S., additional, Yuk, H., additional, Zakamska, N. L., additional, Zhu, W., additional, Anderson, M. D., additional, Arévalo, P., additional, Bazhaw, C., additional, Bisogni, S., additional, Borman, G. A., additional, Bottorff, M. C., additional, Brandt, W. N., additional, Breeveld, A. A., additional, Cackett, E. M., additional, Carini, M. T., additional, Crenshaw, D. M., additional, De Lorenzo-Cáceres, A., additional, Dietrich, M., additional, Edelson, R., additional, Efimova, N. V., additional, Ely, J., additional, Evans, P. A., additional, Ferland, G. J., additional, Flatland, K., additional, Gehrels, N., additional, Geier, S., additional, Gelbord, J. M., additional, Grupe, D., additional, Gupta, A., additional, Hall, P. B., additional, Hicks, S., additional, Horenstein, D., additional, Horne, Keith, additional, Hutchison, T., additional, Im, M., additional, Joner, M. D., additional, Jones, J., additional, Kaastra, J., additional, Kaspi, S., additional, Kelly, B. C., additional, Kennea, J. A., additional, Kim, M., additional, Kim, S. C., additional, Klimanov, S. A., additional, Lee, J. C., additional, Leonard, D. C., additional, Lira, P., additional, MacInnis, F., additional, Mathur, S., additional, McHardy, I. M., additional, Montouri, C., additional, Musso, R., additional, Nazarov, S. V., additional, Netzer, H., additional, Norris, R. P., additional, Nousek, J. A., additional, Okhmat, D. N., additional, Papadakis, I., additional, Parks, J. R., additional, Pott, J.-U., additional, Rafter, S. E., additional, Rix, H.-W., additional, Saylor, D. A., additional, Schnülle, K., additional, Sergeev, S. G., additional, Siegel, M., additional, Skielboe, A., additional, Spencer, M., additional, Starkey, D., additional, Sung, H.-I., additional, Teems, K. G., additional, Turner, C. S., additional, Uttley, P., additional, Villforth, C., additional, Weiss, Y., additional, Woo, J.-H., additional, Yan, H., additional, Young, S., additional, and Zu, Y., additional
Published: 2017
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45. Proteomic profiling of Trastuzumab (Herceptin(R))-sensitive and -resistant SKBR-3 breast cancer cells

Author: DI CARA, G., Marengo, G., Albanese, N., Marabeti, M., Musso, R., Cancemi, P., Pucci, I., DI CARA, G., Marengo, G., Albanese, N., Marabeti, M., Musso, R., Cancemi, P., and Pucci, I.
Subjects: Trastuzumab, Herceptin(R), Breast Cancer, Proteomics, Blotting, Western, Antineoplastic Agents, Breast Neoplasms, Trastuzumab, Antibodies, Monoclonal, Humanized, Mass Spectrometry, Settore BIO/13 - Biologia Applicata, Drug Resistance, Neoplasm, Cell Line, Tumor, Humans, Electrophoresis, Gel, Two-Dimensional, Female, Settore BIO/06 - Anatomia Comparata E Citologia, Transcriptome, Cell Proliferation
Abstract: BACKGROUND: The Human Epidermal Growth Factor Receptor 2 (HER-2), overexpressed in 25-30% of breast carcinomas (BC), is the therapeutic target for trastuzumab, a recombinant humanized monoclonal antibody. The initial response to trastuzumab is often followed by drug-insensitivity within one year. Several hypotheses have been raised to explain this event, but the mechanisms behind the responses to trastuzumab are still unclear. Aim: To study the effects of short and prolonged trastuzumab treatment on the proteomic profiles of HER-2-overexpressing SKBR-3 BC cells. MATERIALS AND METHODS: Cells were treated with trastuzumab to obtain sensitive and resistant clones. The drug effects were evaluated at the phenotypical and proteomic levels. RESULTS: In the trastuzumab-resistant cells the expression of a large amount of proteins, initially affected by treatment, reverted to levels of the untreated cells. CONCLUSION: The results obtained so far illustrate for the first time a large-scale differential protein expression between trastuzumab-treated and untreated cells, and between trastuzumab-sensitive and resistant cells. We believe that the results obtained will help to increase the knowledge of the molecular effects of trastuzumab and will be useful to better-understand the drug resistance mechanisms.
Published: 2013

46. Phenotypic profiling of osteotropic breast cancer cells

Author: Pucci Minafra, I., Di Cara, G., Musso, R., Albanese, N. N., Peri, G., Valentino, B., D’Arienzo, M., Martini, D., and Raspanti, Mario
Published: 2015

47. Efficacy and safety of prophylaxis with once-weekly BAY 79-4980 compared with thrice-weekly rFVIII-FS in haemophilia A patients: A randomised, active-controlled, double-blind study

Author: Powell, Jerry, Martinowitz, Uri, Windyga, Jerzy, Hellmann, Andrzej, Pabinger, Ingrid, Enriquez, Monika Maas, Schwartz, Lawrence, Ingerslev, Jørgen, Group Author: Pabinger Fasching I, Hermans C, Poon MC, Ritchie B, Tinmouth A, Teitel J, Zupancic Salek S, Ingerslev J, Chambos H, Schved JF, Guillet B, Oldenburg J, Klamroth R, Martinowitz U, Santagostino E, Schinco P, Musso R, Morfini M, Rocin A, Meijer K, Larosvan B, Holme P, Windyga J, Skotnicki A, Hellmann A, Zawilska K, Robak T, Soto I, Haya S, Kavakli K, Antmen B, Yesilipek MA, Hay C, Wilde J, Rangarajan S, Bernstein J, Damon L, Gill J, Gruppo R, Cuker A, Kuriakose P, Lin J, Manco Johnson M, Mathew P, Neufeld E, Soni A, Powell J, Kulkarni R, Wicklund B., DI MINNO, GIOVANNI, DI MINNO, MATTEO, Powell, Jerry, Martinowitz, Uri, Windyga, Jerzy, DI MINNO, Giovanni, Hellmann, Andrzej, Pabinger, Ingrid, Enriquez, Monika Maa, Schwartz, Lawrence, Ingerslev, Jørgen, Group Author: Pabinger Fasching, I, Hermans, C, Poon, Mc, Ritchie, B, Tinmouth, A, Teitel, J, Zupancic Salek, S, Ingerslev, J, Chambos, H, Schved, Jf, Guillet, B, Oldenburg, J, Klamroth, R, Martinowitz, U, DI MINNO, Matteo, Santagostino, E, Schinco, P, Musso, R, Morfini, M, Rocin, A, Meijer, K, Larosvan, B, Holme, P, Windyga, J, Skotnicki, A, Hellmann, A, Zawilska, K, Robak, T, Soto, I, Haya, S, Kavakli, K, Antmen, B, Yesilipek, Ma, Hay, C, Wilde, J, Rangarajan, S, Bernstein, J, Damon, L, Gill, J, Gruppo, R, Cuker, A, Kuriakose, P, Lin, J, Manco Johnson, M, Mathew, P, Neufeld, E, Soni, A, Powell, J, Kulkarni, R, and Wicklund, B.
Subjects: 0301 basic medicine, Male, Sucrose, rFVIII-FS, Chemistry, Pharmaceutical, 030204 cardiovascular system & hematology, Polyethylene Glycol, Polyethylene Glycols, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Delayed-Action Preparation, Clinical endpoint, Medicine, Prophylaxi, Hematology, Middle Aged, Liposome, PEGylated liposome, Treatment Outcome, Tolerability, Solvent, Human, Adult, medicine.medical_specialty, Haemophilia, Adolescent, Haemophilia A, Hemorrhage, Hemophilia A, Drug Administration Schedule, 03 medical and health sciences, Young Adult, Double-Blind Method, Internal medicine, Humans, Dosing, Factor VIII, business.industry, medicine.disease, Surgery, Regimen, 030104 developmental biology, Delayed-Action Preparations, Liposomes, Solvents, business, Bay
Abstract: SummaryThe benefits of prophylaxis of haemophilia A patients regarding joint health and quality-of-life are well established. However, adherence to an up to every-other-day infusion regimen is a barrier to widespread adoption of prophylaxis. BAY 79–4980 is an investigational drug consisting of rFVIII-FS (sucrose-formulated recombinant FVIII) reconstituted with liposome solvent. Previous clinical studies showed extended protection from bleeding after a single injection of BAY 79–4980 (13.3 ± 6.2 days) compared with rFVIII-FS (7.2 ± 1.7 days). The effect of once-a-week prophylaxis with BAY 79–4980 (35 IU/kg) compared with three times-per-week rFVIII-FS (25 IU/kg) in previously treated, severe haemophilia A patients was evaluated in a 52-week, double-blind, two-arm, randomised, controlled study. The primary and secondary endpoints were protection from total bleeds and joint bleeds, respectively. Short- and long-term safety and tolerability of BAY 79–4980 including effects on lipid levels were assessed. A total of 139 and 131 subjects were evaluable for safety and efficacy analyses, respectively. A large difference in efficacy between treatment groups was observed with 72.1% (49/68) in the rFVIII-FS control group demonstrating
Published: 2012

48. Analysis of Trastuzumab effects in breast cancer cells in vitro

Author: Di Cara, G, Musso, R, Costantini, F, Marabeti MR, ALBANESE, Nadia Ninfa, CANCEMI, Patrizia, PUCCI, Ida, Di Cara, G, Albanese, NN, Musso, R, Costantini, F, Marabeti MR, Cancemi, P, and Pucci, I
Subjects: Herceptin Maldi-Tof
Published: 2011

49. BEHAVIOVRAL CHANGES OF BREAST CANCER CELLS IN VITRO

Author: Pucci Minafra, I, ALBANESE, Nadia Ninfa, Di Cara, G, Marabeti, MR, Musso, R, Minafra, S., CANCEMI, Patrizia, Pucci-Minafra, I, Cancemi, P, Albanese, NN, Di Cara, G, Marabeti, MR, Musso, R, and Minafra, S
Subjects: BREAST CANCER
Published: 2011

50. PHENOTYPIC PROFILING OF THYROID CARCINOMA CELL LINES AND DIFFERENTIAL SECRETION OF MATRIX METALLOPROTEINASES

Author: Musso R, Di Cara G, ALBANESE, Nadia Ninfa, Marabeti MR, Martini D, Franchi M, Orsini E, Giordano C, Pucci Minafra I., CANCEMI, Patrizia, Musso R, Di Cara G, AlbaneseNN, Marabeti MR, Cancemi P, Martini D, Franchi M, Orsini E, Giordano C, and Pucci-Minafra I.
Subjects: MATRIX METALLOPROTEINASES
Published: 2011

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