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269 results on '"Muthana, Munitta"'

3. Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy

Author

Al-janabi, Haider, primary, Moyes, Katy, additional, Allen, Richard J, additional, Fisher, Matthew, additional, Crespo, Mateus, additional, Gurel, Bora, additional, Rescigno, Pasquale, additional, De Bono, Johann, additional, Nunns, Harry, additional, Bailey, Christopher, additional, Juncker-Jensen, Anna, additional, Muthana, Munitta, additional, Phillips, Wayne A, additional, Pearson, Helen, additional, Taplin, Mary-Ellen, additional, Brown, Janet E, additional, and Lewis, Claire E, additional

Published
2024
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5. In-vitro assays for immuno-oncology drug efficacy assessment and screening for personalized cancer therapy: scopes and challenges.

Author

Rahman, Md Marufur, Wells, Greg, Rantala, Juha K., Helleday, Thomas, Muthana, Munitta, and Danson, Sarah J.

Subjects
DRUG efficacy, CANCER treatment, TREATMENT effectiveness, EARLY detection of cancer, RESEARCH personnel
Abstract

Immunotherapies have revolutionized cancer treatment, but often fail to produce desirable therapeutic outcomes in all patients. Due to the inter-patient heterogeneity and complexity of the tumor microenvironment, personalized treatment approaches are gaining demand. Researchers have long been using a range of in-vitro assays including 2D models, organoid co-cultures, and cancer-on-a-chip platforms for cancer drug screening. A comparative analysis of these assays with their suitability, high-throughput capacity, and clinical translatability is required for optimal translational use. The review summarized in-vitro platforms with their comparative advantages and limitations including construction strategies, and translational potential for immuno-oncology drug efficacy assessment. We also discussed end-point analysis strategies so that researchers can contextualize their usefulness and optimally design experiments for personalized immunotherapy efficacy prediction. Researchers developed several in-vitro platforms that can provide information on personalized immunotherapy efficacy from different angles. Image-based assays are undoubtedly more suitable to gather a wide range of information including cellular morphology and phenotypical behaviors but need significant improvement to overcome issues including background noise, sample preparation difficulty, and long duration of experiment. More studies and clinical trials are needed to resolve these issues and validate the assays before they can be used in real-life scenarios. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Proliferating Cell Nuclear Antigen in the Era of Oncolytic Virotherapy.

Author

Kwan, Amy, Mcdermott-Brown, India, and Muthana, Munitta

Subjects
PROLIFERATING cell nuclear antigen, ONCOLYTIC virotherapy, DNA replication, INFLAMMATION, MOBILE genetic elements
Abstract

Proliferating cell nuclear antigen (PCNA) is a well-documented accessory protein of DNA repair and replication. It belongs to the sliding clamp family of proteins that encircle DNA and acts as a mobile docking platform for interacting proteins to mount and perform their metabolic tasks. PCNA presence is ubiquitous to all cells, and when located in the nucleus it plays a role in DNA replication and repair, cell cycle control and apoptosis in proliferating cells. It also plays a crucial role in the infectivity of some viruses, such as herpes simplex viruses (HSVs). However, more recently it has been found in the cytoplasm of immune cells such as neutrophils and macrophages where it has been shown to be involved in the development of a pro-inflammatory state. PCNA is also expressed on the surface of certain cancer cells and can play a role in preventing immune cells from killing tumours, as well as being associated with cancer virulence. Given the growing interest in oncolytic viruses (OVs) as a novel cancer therapeutic, this review considers the role of PCNA in healthy, cancerous, and immune cells to gain an understanding of how PCNA targeted therapy and oncolytic virotherapy may interact in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Contributors

Author

Ainslie, Kristy M., primary, Al-Dossary, Amal A., additional, Al-Jamal, Khuloud T., additional, Amiji, Mansoor M., additional, Bachelder, Eric M., additional, Dhadwar, Baljevan, additional, Basireddy, Shreya, additional, Batra, Surinder K., additional, Beck, Wolfgang A., additional, Ben-Akiva, Elana, additional, Carpenter, Brandon W., additional, Castro, Flávia, additional, Chen, Guiyuan, additional, Dalal, Vipin, additional, Peer, Dan, additional, Doran, Peter, additional, Gautam, Shailendra K., additional, Graham-Gurysh, Elizabeth G., additional, Green, Jordan J., additional, Hay, Ian, additional, Nutter Howard, Faith Hannah, additional, Huang, Di, additional, Iscaro, Alessandra, additional, Jain, Maneesh, additional, Karlsson, Johan, additional, Katoh, Hiroshi, additional, Kim, Dongyoon, additional, Kulkarni, Ashish A., additional, Kwon, Soonbum, additional, Lang, Tianqun, additional, Li, Jiahe, additional, Li, Jiawei, additional, Li, Yamin, additional, Li, Yaping, additional, Liu, Zhaoji, additional, Lu, Xin, additional, Matosevic, Sandro, additional, Milane, Lara, additional, Min, Yuanzeng, additional, Muthana, Munitta, additional, Oh, Yu-Kyoung, additional, Padmakumar, Smrithi, additional, Parayath, Neha, additional, Rahmy, Sharif, additional, Ramesh, Anujan, additional, Sarmento, Bruno, additional, Scott, Myria, additional, Stephens, Elisa, additional, Stotsky, Lior, additional, Su, Lanhong, additional, Sun, Xin, additional, Tarab, Dana, additional, Tzeng, Stephany Y., additional, Varma, Devika M., additional, Vincent, Benjamin G., additional, Walters, Adam A., additional, Wang, Andrew Z., additional, Wu, Yina, additional, Wu, Yuqianxun, additional, Xu, Qiaobing, additional, Yeo, Yoon, additional, Yin, Qi, additional, Yu, Hongzhe, additional, Zhang, Yong, additional, and Zhu, Runqi, additional

Published
2022
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13. Supplementary Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors

Author

Kwan, Amy, primary, Winder, Natalie, primary, Atkinson, Emer, primary, Al-Janabi, Haider, primary, Allen, Richard J., primary, Hughes, Russell, primary, Moamin, Mohammed, primary, Louie, Rikah, primary, Evans, Dhanajay, primary, Hutchinson, Matthew, primary, Capper, Drew, primary, Cox, Katie, primary, Handley, Joshua, primary, Wilshaw, Adam, primary, Kim, Taewoo, primary, Tazzyman, Simon J., primary, Srivastava, Sanjay, primary, Ottewell, Penelope, primary, Vadakekolathu, Jayakumar, primary, Pockley, Graham, primary, Lewis, Claire E., primary, Brown, Janet E., primary, Danson, Sarah J., primary, Conner, Joe, primary, and Muthana, Munitta, primary

Published
2023
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14. Data from Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors

Author

Kwan, Amy, primary, Winder, Natalie, primary, Atkinson, Emer, primary, Al-Janabi, Haider, primary, Allen, Richard J., primary, Hughes, Russell, primary, Moamin, Mohammed, primary, Louie, Rikah, primary, Evans, Dhanajay, primary, Hutchinson, Matthew, primary, Capper, Drew, primary, Cox, Katie, primary, Handley, Joshua, primary, Wilshaw, Adam, primary, Kim, Taewoo, primary, Tazzyman, Simon J., primary, Srivastava, Sanjay, primary, Ottewell, Penelope, primary, Vadakekolathu, Jayakumar, primary, Pockley, Graham, primary, Lewis, Claire E., primary, Brown, Janet E., primary, Danson, Sarah J., primary, Conner, Joe, primary, and Muthana, Munitta, primary

Published
2023
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16. Supplementary Figures S1-S7 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
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21. Supplementary Table S1 from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
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22. Data from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
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24. Supplementary Figure 2 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
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27. Supplementary Figure 4 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
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29. Supplementary Figure 1 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
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31. Supplementary Figure 3 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
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32. Supplementary Figure 5 from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
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33. Data from Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Author

Muthana, Munitta, primary, Giannoudis, Athina, primary, Scott, Simon D., primary, Fang, Hsin-Yu, primary, Coffelt, Seth B., primary, Morrow, Fiona J., primary, Murdoch, Craig, primary, Burton, Julian, primary, Cross, Neil, primary, Burke, Bernard, primary, Mistry, Roshna, primary, Hamdy, Freddie, primary, Brown, Nicola J., primary, Georgopoulos, Lindsay, primary, Hoskin, Peter, primary, Essand, Magnus, primary, Lewis, Claire E., primary, and Maitland, Norman J., primary

Published
2023
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34. Supplementary Figure Legends from Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Author

Hughes, Russell, primary, Qian, Bin-Zhi, primary, Rowan, Charlotte, primary, Muthana, Munitta, primary, Keklikoglou, Ioanna, primary, Olson, Oakley C., primary, Tazzyman, Simon, primary, Danson, Sarah, primary, Addison, Christina, primary, Clemons, Mark, primary, Gonzalez-Angulo, Ana Maria, primary, Joyce, Johanna A., primary, De Palma, Michele, primary, Pollard, Jeffrey W., primary, and Lewis, Claire E., primary

Published
2023
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36. Development of a Personalised Device for Systemic Magnetic Drug Targeting to Brain Tumours

Author

Patel, Priya, primary, Alghamdi, Areej, additional, Shaw, Gary, additional, Legge, Christopher, additional, Glover, Maggie, additional, Freeman, Danielle, additional, Hodgetts, Harry, additional, Wilson, Erica, additional, Howard, Faith, additional, Staniland, Sarah, additional, Kennerley, Aneurin J, additional, Wood, Duncan, additional, Moorehead, Robert, additional, Hadfield, Charlotte, additional, Rominiyi, Ola, additional, Griffin, Jon, additional, Collis, Spencer J, additional, Hyde, Sam, additional, Crossley, Marcus, additional, Paley, Martyn, additional, and Muthana, Munitta, additional

Published
2023
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38. Macrophage Delivered HSV1716 Is Active against Triple Negative Breast Cancer

Author

Kwan, Amy, primary, Howard, Faith, additional, Winder, Natalie, additional, Atkinson, Emer, additional, Jailani, Ameera, additional, Patel, Priya B., additional, Allen, Richard, additional, Ottewell, Penelope D., additional, Shaw, Gary C., additional, Conner, Joe, additional, Wilson, Caroline, additional, Srivastava, Sanjay K., additional, Danson, Sarah J., additional, Lewis, Claire, additional, Brown, Janet E., additional, and Muthana, Munitta, additional

Published
2022
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46. Nanobugs as Drugs: Bacterial Derived Nanomagnets Enhance Tumor Targeting and Oncolytic Activity of HSV‐1 Virus

Author

Howard, Faith H N, primary, Al‐Janabi, Haider, additional, Patel, Priya, additional, Cox, Katie, additional, Smith, Emily, additional, Vadakekolathu, Jayakumar, additional, Pockley, A. Graham, additional, Conner, Joe, additional, Nohl, James F, additional, Allwood, Dan A, additional, Collado‐Rojas, Cristal, additional, Kennerley, Aneurin, additional, Staniland, Sarah, additional, and Muthana, Munitta, additional

Published
2022
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