132 results on '"N, Merkle"'
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2. Training for Emergencies - How Germany is Preparing for Large-Scale Emergencies Using the EUROMED 2024 Civil Protection Exercise as an Example
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V. Gstaiger, N. Machinia, N. Merkle, D. Rosenbaum, R. Nippold, M. Muehlhaus, P. d’Angelo, C. Henry, X. Yuan, R. Bahmanyar, F. Kurz, and C.-M. Krieg
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Every year, numerous major events with thousands of participants take place around the world, for which extensive safety measures are taken to ensure the well-being and safety of visitors. Nevertheless, incidents that lead to injuries and deaths occur time and again. This year, Germany is looking forward to the UEFA EURO 2024, an international football championship for which the host country, Germany, has made extensive preparations on several levels. One component of this is the Medical Task Force (MTF) of the Federal Office of Civil Protection and Disaster Assistance (BBK), which has trained a possible medical service deployment in the event of a mass casualty incident with a specially coordinated series of exercises. The extent to which current remote sensing data can make a useful contribution and be meaningfully integrated was analyzed during the large-scale EUROMED exercise with the help of an airborne camera system on board a helicopter. The system provided up-to-date aerial images of the exercise site, but was also used to record the traffic situation during the transfer of the vehicle convoys to the exercise site. In addition, state-of-the-art AI-based image analysis methods were tested on site and the results were provided and evaluated. An important operational exercise to bring science and practice together step by step in order to be better prepared for an emergency.
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- 2024
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3. SAVING LIVES FROM ABOVE: PERSON DETECTION IN DISASTER RESPONSE USING DEEP NEURAL NETWORKS
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R. Bahmanyar and N. Merkle
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
This paper focuses on person detection in aerial and drone imagery, which is crucial for various operations such as situational awareness, search and rescue, and safe delivery of supplies. We aim to improve disaster response efforts by enhancing the speed, safety, and effectiveness of the process. Therefore, we introduce a new person detection dataset comprising 311 annotated aerial and drone images, acquired from helicopters and drones in different scenes, including urban and rural areas, and for different scenarios, such as estimation of damage in disaster-affected zones, and search and rescue operations in different countries. The amount of data considered and level of detail of the annotations resulted in a total of 10,050 annotated persons. To detect people in aerial and drone images, we propose a multi-stage training procedure to improve YOLOv3’s ability. The proposed procedure aims at addressing challenges such as variations in scenes, scenarios, people poses, as well as image scales and viewing angles. To evaluate the effectiveness of our proposed training procedure, we split our dataset into a training and a test set. The latter includes images acquired during real search and rescue exercises and operations, and is therefore representative for the challenges encountered during operational missions and suitable for an accurate assessment of the proposed models. Experimental results demonstrate the effectiveness of our proposed training procedure, as the model’s average precision exhibits a relevant increase with respect to the baseline value.
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- 2023
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4. USING EARTH OBSERVATION TO SUPPORT FIRST AID RESPONSE IN CRISIS SITUATIONS– LESSONS LEARNED FROM THE EARTHQUAKE IN TÜRKIYE/SYRIA (2023)
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A. Schneibel, M. Gähler, M. Halbgewachs, R. Berger, J. Brauchle, M. Geßner, V. Gstaiger, D. Hein, C. Henry, N. Merkle, and D. Klein
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
In the early morning hours on Tuesday, February 6, 2023, the southern part of Türkiye was struck by two large and several smaller earthquakes, causing destruction and casualties over a remarkably large area. In such cases, quick response and well-informed coordination is a key factor to successful first aid responses since damage and the number of people buried or in need often remain unclear in the hours after the disaster. The German Aerospace Center (DLR) responded to the earthquake by rapidly providing a number of information products, all above very high-resolution imagery in an easy-to-use web-based application. Next to satellite and drone imagery, damage information and pre-disaster imagery were provided to the users. Drone imagery was acquired in person for Kirikhan, a city in the south of the disaster area. Access to the viewer was granted to authorized users from public authorities, humanitarian aid organisations, and research institutes. Furthermore, DLR generated information products in the fields of settlement pattern, AI based damage assessment and tectonic movements. These data, as scientifically significant as they are, were not part of the web viewer. Within this paper, the reasons will be assessed as well as the general workflow of the activation. The paper will also discuss what steps need to be taken to ensure research outcomes being integrated into information products for users in future and how to prepare for the next disaster to still ensure a quick response but with an enriched product suite.
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- 2023
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5. Introduction to imaging of cartilage
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Alexander N. Merkle and Corey K. Ho
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Diseases of the musculoskeletal system ,RC925-935 ,Other systems of medicine ,RZ201-999 ,Sports medicine ,RC1200-1245 - Published
- 2024
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6. GENERATION OF REFERENCE VEHICLE TRAJECTORIES IN REAL-WORLD SITUATIONS USING AERIAL IMAGERY FROM A HELICOPTER
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F. Kurz, P. Mendes, V. Gstaiger, R. Bahmanyar, P. d’Angelo, S. M. Azimi, S. Auer, N. Merkle, C. Henry, D. Rosenbaum, J. Hellekes, H. Runge, F. Toran, and P. Reinartz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Highly accurate reference vehicle trajectories are required in the automotive domain e. g. for testing mobile GNSS devices. Common methods used to determine reference trajectories are based on the same working principles as the device under test and suffer from the same underlying error problems. In this paper, a new method to generate reference vehicle trajectories in real-world situations using simultaneously acquired aerial imagery from a helicopter is presented. This method requires independent height information which is coming from a LIDAR DTM and the relative height of the GNSS device. The reference trajectory is then derived by forward intersection of the vehicle position in each image with the DTM. In this context, the influence of all relevant error sources were analysed, like the error from the LIDAR DTM, from the sensor latency, from the semi-automatic matching of the vehicle marking, and from the image orientation. Results show that the presented method provides a tool for creating reference trajectories that is independent of the GNSS reception at the vehicle. Moreover, it can be demonstrated that the proposed method reaches an accuracy level of 10 cm, which is defined as necessary for certification and validation of automotive GNSS devices.
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- 2022
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7. ROAD CONDITION ASSESSMENT FROM AERIAL IMAGERY USING DEEP LEARNING
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N. Merkle, C. Henry, S. M. Azimi, and F. Kurz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Terrestrial sensors are commonly used to inspect and document the condition of roads at regular intervals and according to defined rules. For example in Germany, extensive data and information is obtained, which is stored in the Federal Road Information System and made available in particular for deriving necessary decisions. Transverse and longitudinal evenness, for example, are recorded by vehicles using laser techniques. To detect damage to the road surface, images are captured and recorded using area or line scan cameras. All these methods provide very accurate information about the condition of the road, but are time-consuming and costly. Aerial imagery (e.g. multi- or hyperspectral, SAR) provide an additional possibility for the acquisition of the specific parameters describing the condition of roads, yet a direct transfer from objects extractable from aerial imagery to the required objects or parameters, which determine the condition of the road is difficult and in some cases impossible. In this work, we investigate the transferability of objects commonly used for the terrestrial-based assessment of road surfaces to an aerial image-based assessment. In addition, we generated a suitable dataset and developed a deep learning based image segmentation method capable of extracting two relevant road condition parameters from high-resolution multispectral aerial imagery, namely cracks and working seams. The obtained results show that our models are able to extraction these thin features from aerial images, indicating the possibility of using more automated approaches for road surface condition assessment in the future.
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- 2022
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8. AUTOMATIC OBJECT SEGMENTATION TO SUPPORT CRISIS MANAGEMENT OF LARGE-SCALE EVENTS
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S. M. Azimi, R. Kiefl, V. Gstaiger, R. Bahmanyar, N. Merkle, C. Henry, D. Rosenbaum, and F. Kurz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
The management of large-scale events with a widely distributed camping area is a special challenge for organisers and security forces and requires both comprehensive preparation and attentive monitoring to ensure the safety of the participants. Crucial to this is the availability of up-to-date situational information, e.g. from remote sensing data. In particular, information on the number and distribution of people is important in the event of a crisis in order to be able to react quickly and effectively manage the corresponding rescue and supply logistics. One way to estimate the number of persons especially at night is to classify the type and size of objects such as tents and vehicles on site and to distinguish between objects with and without a sleeping function. In order to make this information available in a timely manner, an automated situation assessment is required. In this work, we have prepared the first high-quality dataset in order to address the aforementioned challenge which contains aerial images over a large-scale festival of different dates. We investigate the feasibility of this task using Convolutional Neural Networks for instance-wise semantic segmentation and carry out several experiments using the Mask-RCNN algorithm and evaluate the results. Results are promising and indicate the possibility of function-based tent classification as a proof-of-concept. The results and thereof discussions can pave the way for future developments and investigations.
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- 2021
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9. CITYWIDE ESTIMATION OF PARKING SPACE USING AERIAL IMAGERY AND OSM DATA FUSION WITH DEEP LEARNING AND FINE-GRAINED ANNOTATION
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C. Henry, J. Hellekes, N. Merkle, S. M. Azimi, and F. Kurz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Emerging traffic management technologies, smart parking applications, together with transport researchers and urban planners are interested in fine-grained data on parking space in cities. However, there are no standardized, complete and up-to-date databases for many urban areas. Moreover, manual data collection is expensive and time-consuming. Aerial imagery of entire cities can be used to inventory not only publicly accessible and dedicated parking lots, but also roadside parking areas and those on private property. For a realistic estimation of the total parking space, the observed use of multi-functional traffic areas is taken into account by segmenting not only parking areas but also roads according to their purpose. In this paper, different U-Net based architectures are tested for detecting all these types of visible traffic areas. A new large-scale, high-quality dataset of manual annotations is used in combination with selected contextual information from OpenStreetMap (OSM) to depict the actual use as parking space. Our models achieve a good performance on parking area segmentation, and we show the significant impact of OSM data fusion in deep neural networks on the simultaneous extraction of multiple traffic areas compared to using aerial imagery alone.
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- 2021
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10. AUTOMATED BUILDING SEGMENTATION AND DAMAGE ASSESSMENT FROM SATELLITE IMAGES FOR DISASTER RELIEF
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X. Yuan, S. M. Azimi, C. Henry, V. Gstaiger, M. Codastefano, M. Manalili, S. Cairo, S. Modugno, M. Wieland, A. Schneibel, and N. Merkle
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
After a natural disaster or humanitarian crisis, rescue forces and relief organisations are dependent on fast, area-wide and accurate information on the damage caused to infrastructure and the situation on the ground. This study focuses on the assessment of building damage levels on optical satellite imagery with a two-step ensemble model performing building segmentation and damage classification trained on a public dataset. We provide an extensive generalization study on pre- and post-disaster data from the passage of the cyclone Idai over Beira, Mozambique, in 2019 and the explosion in Beirut, Lebanon, in 2020. Critical challenges are addressed, including the detection of clustered buildings with uncommon visual appearances, the classification of damage levels by both humans and deep learning models, and the impact of varying imagery acquisition conditions. We show promising building damage assessment results and highlight the strong performance impact of data pre-processing on the generalization capability of deep convolutional models.
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- 2021
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11. Mass-Like Fat at the Medial Midfoot: A Common Pseudolesion
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Colin D. Strickland, Luke W. Patten, Michael J. Durst, and Alexander N. Merkle
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lipoma ,midfoot ,mass ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Background Fatty masses are common and may be encountered in the foot and ankle. In some cases, normal subcutaneous fat may be mistaken for a discrete mass. Aims The aim of this study was to evaluate the common finding of prominent subcutaneous fat at the medial midfoot resembling a lipoma and to determine the prevalence of this pseudolesion by applying a series of potential size cutoff criteria. Materials and Methods Three musculoskeletal radiologists retrospectively evaluated 91 sequentially performed magnetic resonance imaging examinations of the ankle to measure fat resembling a discrete lipoma at the medial midfoot. Each blinded reader measured the largest area of continuous subcutaneous fat in orthogonal axial, coronal craniocaudal, and coronal transverse dimensions. Patient age, sex, and study indications were also recorded. Statistical analysis was performed with R and SAS 9.4 software Results A discrete fatty pseudolesion as defined by measuring at least 1 cm in all planes by measurements of at least two of three readers was present in 87% of cases (79 of 91). When a size criterion of 1.5 cm was used, a pseudolesion was documented in 14% of cases (13 of 91). There was a significant correlation between larger pseudolesion size and female sex in the axial plane; however, there was no correlation in the coronal craniocaudal and coronal transverse dimensions. Conclusions Subcutaneous fat at the medial midfoot often has a mass-like appearance that could be mistaken for a lipoma. It is important to recognize this pseudolesion variant and not to confuse the imaging appearance for a discrete mass.
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- 2021
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12. REAL-TIME AERIAL IMAGERY FOR CRISIS MANAGEMENT: LESSONS LEARNED FROM AN EUROPEAN CIVIL PROTECTION EXERCISE
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N. Merkle, V. Gstaiger, E. Schröter, P. d’Angelo, S. M. Azimi, U. Kippnich, C. Barthel, and F. Kurz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Regular international civil protection exercises are an important part of the European Civil Protection Mechanism. One such exercise, called IRONORE2019, took place in September 2019 in Eisenerz, Austria, with the aim of training international cooperation of relief teams in case of an earthquake. In parallel to this exercise, the European project DRIVER+ conduced a Trail in order to test novel solutions for civil protection. The German Aerospace Center (DLR) provided aerial imagery as well as derived map products to the project and the exercise, which were also made available to the Bavarian Red Cross, among others, as exercise participants. In this way, products developed using the latest scientific methods could be used and tested in practice. The valuable experiences from this operational use, which are explained in this article, serve the enhancement of the processes and products and will be implemented in the future in order to further support disaster management.
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- 2020
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13. DLRAD – A FIRST LOOK ON THE NEW VISION AND MAPPING BENCHMARK DATASET FOR AUTONOMOUS DRIVING
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F. Kurz, D. Waigand, P. Pekezou-Fouopi, E. Vig, C. Henry, N. Merkle, D. Rosenbaum, V. Gstaiger, S. Azimi, S. Auer, P. Reinartz, and S. Knake-Langhorst
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
DLRAD – a new vision and mapping benchmark dataset for autonomous driving is under development for the validation of intelligent driving algorithms. Stationary, mobile, and airborne sensors monitored simultaneously the environment around a reference vehicle, which was driving on urban, suburb and rural roads in and around the city of Braunschweig/Germany. Airborne images were acquired with the DLR 4k sensor system mounted on a helicopter. The DLR research car FASCarE is equipped with the latest sensor technology like front/rear radar, ultrasound and laser sensors, optical single and stereo cameras, and GNSS/IMU. Additionally, stationary terrestrial sensors like induction loops, optical mono and stereo cameras, radar and laser scanners monitor defined sections of the path from the ground. Simultaneously, the helicopter with the 4k sensor systems follows the reference car by keeping it all the time in the central nadir view. A next crucial step in the construction of the DLRAD benchmark dataset is the annotation of all objects in the reference dataset.The DLRAD benchmark dataset enables a huge variety of validation capabilities and opens a wide field of possibilities for the development, training and validation of machine learning algorithms in the context of autonomous driving. In this paper, we will present details of the sensor configurations and the acquisition campaign, which had taken place between the 18th July and 20th July 2017 in Braunschweig/Germany. Also, we show a first analysis of the data including the completeness and geometrical quality. The dataset will be published as soon as the coregistration and annotations are complete.
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- 2018
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14. AN EVOLUTIONARY ALGORITHM FOR FAST INTENSITY BASED IMAGE MATCHING BETWEEN OPTICAL AND SAR SATELLITE IMAGERY
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P. Fischer, P. Schuegraf, N. Merkle, and T. Storch
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
This paper presents a hybrid evolutionary algorithm for fast intensity based matching between satellite imagery from SAR and very high-resolution (VHR) optical sensor systems. The precise and accurate co-registration of image time series and images of different sensors is a key task in multi-sensor image processing scenarios. The necessary preprocessing step of image matching and tie-point detection is divided into a search problem and a similarity measurement. Within this paper we evaluate the use of an evolutionary search strategy for establishing the spatial correspondence between satellite imagery of optical and radar sensors. The aim of the proposed algorithm is to decrease the computational costs during the search process by formulating the search as an optimization problem. Based upon the canonical evolutionary algorithm, the proposed algorithm is adapted for SAR/optical imagery intensity based matching. Extensions are drawn using techniques like hybridization (e.g. local search) and others to lower the number of objective function calls and refine the result. The algorithm significantely decreases the computational costs whilst finding the optimal solution in a reliable way.
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- 2018
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15. REGISTRATION OF OPTICAL AND SAR SATELLITE IMAGES BASED ON GEOMETRIC FEATURE TEMPLATES
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N. Merkle, R. Müller, and P. Reinartz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Image registration is required for different remote sensing applications, like change detection or image fusion. Since research studies have shown the outstanding absolute geometric accuracy of high resolution radar satellites images like TerraSAR-X, the importance of SAR images as source for geolocation enhancement has increased. Due to this fact, multi-sensor image to image registration of optical and SAR images can be used for the improvement of the absolute geometric processing and accuracy of optical images with TerraSAR-X as reference. In comparison to the common optical and SAR image registration methods the proposed method is a combination of intensity-based and feature-based approaches. The proposed method avoids the direct and often difficult detection of features from the SAR images. SAR-like templates are generated from features detected from the optical image. These templates are used for an intensity-based matching with the SAR image. The results of the matching process are ground control points, which are used for the estimation of translation parameters followed by a subpixel translation of the optical image. The proposed image registration method is tested for two pairs of TerraSAR-X and QuickBird images and one pair of TerraSAR-X andWorldView-2 images of a suburban area. The results show that with the proposed method the geometric accuracy of optical images can be enhanced.
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- 2015
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16. A NEW APPROACH FOR OPTICAL AND SAR SATELLITE IMAGE REGISTRATION
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N. Merkle, R. Müller, P. Schwind, G. Palubinskas, and P. Reinartz
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Applied optics. Photonics ,TA1501-1820 - Abstract
Over the last years several research studies have shown the high geometric accuracy of high resolution radar satellites like TerraSARX. Due to this fact, the impact of high resolution SAR images for image registration has increased. An aim of high accuracy image registration is the improvement of the absolute geometric accuracy of optical images by using SAR images as references. High accuracy image registration is required for different remote sensing applications and is an on-going research topic. The registration of images acquired by different sensor types, like optical and SAR images, is a challenging task. In our work, a novel approach is proposed, which is a combination of the classical feature-based and intensity-based registration approaches. In the first step of the method, spatial features, here roundabouts, are detected in the optical image. In the second step, the detected features are used to generate SAR like roundabout templates. In the third step, the templates are matched with the corresponding parts of the SAR image by using an intensitybased matching process. The proposed method is tested for a pair of TerraSAR-X and QuickBird images and a pair of TerraSAR-X and WorldView-2 images of a suburban area. The results show that the proposed method offers an alternative approach compared to the common optical and SAR images registration methods and it can be used for the geometric accuracy improvement of optical images.
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- 2015
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17. Mass-Like Fat at the Medial Midfoot: A Common Pseudolesion
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Alexander N. Merkle, Colin Strickland, Michael J. Durst, and Luke Patten
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lipoma ,R895-920 ,Subcutaneous fat ,030218 nuclear medicine & medical imaging ,Medical physics. Medical radiology. Nuclear medicine ,03 medical and health sciences ,0302 clinical medicine ,Patient age ,medicine ,Radiology, Nuclear Medicine and imaging ,medicine.diagnostic_test ,business.industry ,Female sex ,Magnetic resonance imaging ,Anatomy ,Lipoma ,medicine.disease ,body regions ,Transverse plane ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Coronal plane ,mass ,Original Article ,midfoot ,Ankle ,business - Abstract
Background Fatty masses are common and may be encountered in the foot and ankle. In some cases, normal subcutaneous fat may be mistaken for a discrete mass. Aims The aim of this study was to evaluate the common finding of prominent subcutaneous fat at the medial midfoot resembling a lipoma and to determine the prevalence of this pseudolesion by applying a series of potential size cutoff criteria. Materials and Methods Three musculoskeletal radiologists retrospectively evaluated 91 sequentially performed magnetic resonance imaging examinations of the ankle to measure fat resembling a discrete lipoma at the medial midfoot. Each blinded reader measured the largest area of continuous subcutaneous fat in orthogonal axial, coronal craniocaudal, and coronal transverse dimensions. Patient age, sex, and study indications were also recorded. Statistical analysis was performed with R and SAS 9.4 software Results A discrete fatty pseudolesion as defined by measuring at least 1 cm in all planes by measurements of at least two of three readers was present in 87% of cases (79 of 91). When a size criterion of 1.5 cm was used, a pseudolesion was documented in 14% of cases (13 of 91). There was a significant correlation between larger pseudolesion size and female sex in the axial plane; however, there was no correlation in the coronal craniocaudal and coronal transverse dimensions. Conclusions Subcutaneous fat at the medial midfoot often has a mass-like appearance that could be mistaken for a lipoma. It is important to recognize this pseudolesion variant and not to confuse the imaging appearance for a discrete mass.
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- 2021
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18. MR Imaging of Knee Cartilage Injury and Repair Surgeries
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Colin D. Strickland, Corey K. Ho, Alexander N. Merkle, and Armando F. Vidal
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Cartilage, Articular ,Chondrocytes ,Knee Joint ,Osteoarthritis ,Humans ,Radiology, Nuclear Medicine and imaging ,Knee Injuries ,Cartilage Diseases ,Magnetic Resonance Imaging - Abstract
Cartilage injuries are common and may predispose to early accelerated osteoarthritis. Magnetic resonance (MR) imaging is critical in the detection and characterization of acute and chronic cartilage injuries. Several surgical approaches including microfracture, osteochondral allografting, autologous osteochondral transfer system, and autologous chondrocyte implantation have been developed to treat cartilage lesions. The goals of these treatments include relief of symptoms, restoration of joint function, and delay of progression of osteoarthritis. Imaging evaluation by MR imaging plays a crucial role in diagnosis and surgical planning as well as monitoring for postoperative complications.
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- 2022
19. Ultrasound-Guided Musculoskeletal Injections
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Jonathan S. Lin, David C. Gimarc, Ronald S. Adler, Luis S. Beltran, and Alexander N. Merkle
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Shoulder ,Tendinopathy ,Humans ,Radiology, Nuclear Medicine and imaging ,Orthopedics and Sports Medicine ,Ultrasonography, Interventional ,Injections ,Ultrasonography - Abstract
Musculoskeletal injections serve a variety of diagnostic and therapeutic purposes, with ultrasonography (US) guidance having many advantages: no ionizing radiation, real-time guidance, high spatial resolution, excellent soft tissue contrast, and the ability to identify and avoid critical structures. Sonography can be cost effective and afford flexibility in resource-constrained settings. This article describes US-guided musculoskeletal injections relevant to many radiology practices and provides experience-based suggestions. Structures covered include multiple joints (shoulder, hip), bursae (iliopsoas, subacromial-subdeltoid, greater trochanteric), peripheral nerves (sciatic, radial), and tendon sheaths (posterior tibial, peroneal, flexor hallucis longus, Achilles, long head of the biceps). Trigger point and similar targeted steroid injections, as well as calcific tendinopathy barbotage, are also described.
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- 2021
20. Bilateral Distal Radius Fractures in a Patient with Osteogenesis Imperfecta: A Case Report
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Jonathan D. Freedman, Matthew L. Iorio, and Alexander N. Merkle
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medicine.medical_specialty ,business.industry ,Middle Aged ,Osteogenesis Imperfecta ,medicine.disease ,Surgery ,Treatment Outcome ,Osteogenesis imperfecta ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Displacement (orthopedic surgery) ,In patient ,Female ,Nonoperative management ,business ,Radius Fractures - Abstract
CASE Longitudinal follow-up of a 53-year-old woman with osteogenesis imperfecta (OI) Type III and concurrent bilateral distal radius fractures is reported. She had a right-sided displaced fracture and a left-sided minimally displaced fracture. Operative management of the displaced fracture showed adequate healing in 10 weeks. The minimally displaced fracture failed nonoperative management but did adequately heal after operative intervention. CONCLUSION Early surgical intervention of distal radius fractures may be considered in patients with severe OI, even in fractures with minimal displacement. This is likely particularly important with patients who are heavily reliant on their upper extremities for mobility.
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- 2021
21. Can Elite Dancers Return to Dance After Ultrasound-Guided Platelet-Rich Plasma (PRP) Injections?
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Alexander N. Merkle, Ronald S. Adler, William G Hamilton, Phillip A. Bauman, and Nidhi Jain
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Adult ,Male ,medicine.medical_specialty ,Cord ,Adolescent ,Dance ,Health Status ,Population ,Injections, Intra-Articular ,Young Adult ,Joint capsule ,Humans ,Medicine ,Dancing ,Young adult ,education ,Ultrasonography, Interventional ,education.field_of_study ,Platelet-Rich Plasma ,business.industry ,Recovery of Function ,General Medicine ,Surgery ,medicine.anatomical_structure ,Platelet-rich plasma ,Female ,Plantar fascia ,Ankle ,business - Abstract
Dancers exert tremendous stresses on the lower extremities rendering them prone to injuries that can curtail training and performance. The goal of this study was to evaluate clinical improvement in a population of elite dancers following treatment with ultrasound-guided platelet-rich plasma (PRP) injections of various lower extremity sites by assessing when they were able to return to dance. Nineteen dancers (13 female, 6 male; ages 15 to 42) were treated between 2009 and 2016 at sites that included: hamstring tendon (1), proximal iliotibial band (1), patellar tendon (3), posterior tibial tendon (5), peroneus brevis tendon (3), plantar fascia (3), and the first metatarsophalangeal (MTP) joint capsule (3). Injections were performed by a single radiologist using the same PRP kit under ultrasound guidance. All patients adhered to standard post-care instructions, including non-weightbearing and avoidance of NSAIDs for at least 2 weeks post-injection. Clinical charts were reviewed for factors including: adherence to post-injection immobilization and physical therapy, physical exam assessments, and milestones in returning to dance. The time-point for returning to dance was defined by attendance of class or rehearsal without symptoms referring to the treated site. Eighteen subjects achieved return to dance, 13 in 6 months or less, and the majority (10) within 3 months of injection. Five subjects required more than 6 months recovery time. These cases all involved foot and ankle sites; of these, two subjects required repeat injections, and both returned to dance within 11 months of the second injection. In the single case where PRP treatment failed, the injury treated was severe plantar fasciopathy with a high-grade central cord tear. It is concluded that ultrasound-guided PRP injections may play a role in the treatment of various lower extremity injuries in elite dancers, with the majority of subjects in this series returning to dance within 6 months. Recovery time may vary depending on the site treated and severity of the presenting injury.
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- 2018
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22. Shear Wave Ultrasound Elastographic Evaluation of the Rotator Cuff Tendon
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Ronald S. Adler, Alexander N. Merkle, James S. Babb, Soterios Gyftopoulos, Stephanie W. Hou, and Robert McCabe
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030222 orthopedics ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Shoulders ,Ultrasound ,Deltoid curve ,Asymptomatic ,030218 nuclear medicine & medical imaging ,Surgery ,Tendon ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Deltoid muscle ,medicine ,Radiology, Nuclear Medicine and imaging ,Rotator cuff ,Radiology ,Elastography ,medicine.symptom ,business - Abstract
Objectives (1) Assess the association between the B-mode morphologic appearance and elasticity in the rotator cuff tendon using shear wave elastography (SWE). (2) Assess the association between SWE and symptoms. Methods Institutional Review Board approval and informed consent were obtained. A retrospective review identified 21 studies in 19 eligible patients for whom SWE was performed during routine sonographic evaluations for shoulder pain. Evaluations were compared with 55 studies from 16 asymptomatic volunteers and 6 patients with asymptomatic contralateral shoulders. Repeated studies were accounted for by resampling. Proximal and distal tendon morphologic characteristics were graded from 1 to 4 (normal to full-thickness tear), and average shear wave velocity (SWV) measurements were obtained at both locations. In 68 examinations, deltoid muscle SWV measurements were available for post hoc analysis. Results The morphologic grade and SWV showed weak-to-moderate negative correlations in the proximal (P
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- 2016
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23. Advanced MRI Techniques of the Shoulder Joint: Current Applications in Clinical Practice
- Author
-
Jenny T. Bencardino, Christopher J. Gottsegen, Alexander N. Merkle, and Soterios Gyftopoulos
- Subjects
medicine.medical_specialty ,Routine practice ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Imaging, Three-Dimensional ,medicine ,Image Processing, Computer-Assisted ,Humans ,Radiology, Nuclear Medicine and imaging ,Routine clinical practice ,Medical physics ,Pace ,Mri techniques ,030222 orthopedics ,business.industry ,Shoulder Joint ,General Medicine ,Image Enhancement ,Magnetic Resonance Imaging ,Clinical Practice ,Shoulder MRI ,Radiology ,Joint Diseases ,Shoulder Injuries ,business - Abstract
We are fortunate to live in a time when real advances in medicine are happening at an increasingly rapid pace. This is especially true in the field of radiology, and keeping abreast of these advances is one of the main challenges of clinical practice. Traditionally, cutting edge techniques in our field have been researched and validated at major academic medical centers before slowly making their way into the armamentarium of routine clinical practice. However, the improved ability to communicate and disseminate information in our modern age has facilitated more rapid implementation of new techniques to allow us to better serve our patients.As such, this article aims to review the current standards for MRI of the shoulder used in routine practice. Furthermore, we will discuss some of the most recent advances in shoulder MRI, with particular emphasis on the applicability of an additional axial 3D T1-weighted FLASH sequence with Dixon-based water-fat separation in routine clinical practice that can be useful in characterizing several commonly encountered pathologic processes of the shoulder joint.
- Published
- 2017
24. Konsensusempfehlungen der DRG/DGK/DGPK zum Einsatz der Herzbildgebung mit Computertomographie und Magnetresonanztomographie
- Author
-
S. Achenbach, J. Barkhausen, M. Beer, P. Beerbaum, T. Dill, J. Eichhorn, S. Fratz, M. Gutberlet, M. Hoffmann, A. Huber, P. Hunold, C. Klein, G. Krombach, K.-F. Kreitner, T. Kühne, J. Lotz, D. Maintz, H. Marholdt, N. Merkle, D. Messroghli, S. Miller, I. Paetsch, P. Radke, H. Steen, H. Thiele, S. Sarikouch, and R. Fischbach
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2012
- Full Text
- View/download PDF
25. Konsensusempfehlungen der DRG/DGK/DGPK zum Einsatz der Herzbildgebung mit Computertomografie und Magnetresonanztomografie
- Author
-
D. Messroghli, K.-F. Kreitner, Matthias Gutberlet, Stephan Achenbach, H. Mahrholdt, David Maintz, S. Sarikouch, P Hunold, A. Huber, Holger Thiele, Stephan Miller, Gabriele A. Krombach, T. Dill, Joerg Barkhausen, N. Merkle, C. Klein, I. Paetsch, Jeffrey C. Lotz, Sohrab Fratz, M. Hoffmann, PW Radke, H. Steen, T. Kühne, Joachim Eichhorn, Philipp Beerbaum, Meinrad Beer, and Roman Fischbach
- Subjects
medicine.medical_specialty ,Modalities ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Context (language use) ,medicine.disease ,language.human_language ,German ,Coronary artery disease ,Cardiac magnetic resonance imaging ,medicine ,language ,Radiology, Nuclear Medicine and imaging ,Radiology ,Tomography ,business ,Cardiac imaging - Abstract
Cardiac magnetic resonance imaging (MRI) and computed tomography (CT) have been developed rapidly in the last decade. Technical improvements and broad availability of modern CT and MRI scanners have led to an increasing and regular use of both diagnostic methods in clinical routine. Therefore, this German consensus document has been developed in collaboration by the German Cardiac Society, German Radiology Society, and the German Society for Pediatric Cardiology. It is not oriented on modalities and methods, but rather on disease entities. This consensus document deals with coronary artery disease, cardiomyopathies, arrhythmias, valvular diseases, pericardial diseases and structural changes, as well as with congenital heart defects. For different clinical scenarios both imaging modalities CT and MRI are compared and evaluated in the specific context.
- Published
- 2012
- Full Text
- View/download PDF
26. Die Rolle der Kardio-MRT bei Diagnose und Prognosebeurteilung der Herzinsuffizienz
- Author
-
Wolfgang Rottbauer, Vinzenz Hombach, Peter Bernhardt, V. Rasche, and N. Merkle
- Subjects
medicine.medical_specialty ,Ischemic cardiomyopathy ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Cardiomyopathy ,Magnetic resonance imaging ,medicine.disease ,Contractility ,Heart failure ,Internal medicine ,Myocardial scarring ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Abstract
Cardiovascular magnetic resonance (CMR) imaging is a tomographic technique, which allows three-dimensional slice orientation without limitations from acoustic windows inherent to echocardiography. Further advantages of CMR are its high temporal and spatial resolution, its excellent soft tissue resolution and its high blood-to-tissue contrast. Cardiovascular magnetic resonance is currently the only imaging technique, which provides a comprehensive study of both structure and function of the heart as well as myocardial perfusion and viability. Moreover, post-processing of CMR images does not require any geometric assumptions as in echocardiography to determine ventricular dimensions. This is particularly important when evaluating ventricles of patients with chronic heart failure with severely altered morphology that may have regional variations in wall thickness and contractility at least in ischemic cardiomyopathy. The highly reproducible results of CMR imaging have turned this technique into a reference standard for the non-invasive assessment of ventricular dimensions, mass and function. In cases with indeterminate results of clinical, electrocardiographic and particularly echocardiographic findings CMR should be used early in the process of diagnosis of patients with heart failure. Not only can altered structure and degree of ventricular and valvular dysfunctions be accurately assessed but also regional perfusion deficits and/or myocardial scars are easily detected. For therapeutic and prognostic reasons a simple differentiation between ischemic and non-ischemic cardiomyopathy should be achieved as the first diagnostic step. In addition, the type and localization of the late gadolinium enhancement (LGE) phenomenon may aid in non-invasively differentiating the etiology of non-ischemic cardiomyopathy. CMR may also improve the assessment and extent of interventricular and intraventricular dyssynchrony in patients to be selected for cardiac resynchronization therapy (CRT). Lastly, the LGE phenomenon may provide independent prognostic information in patients with a CRT system implanted, as well as in patients with ischemic and non-ischemic cardiomyopathy. Thus, CMR imaging should be implemented early in the diagnostic process of patients with heart failure to significantly improve the speed and accuracy of diagnostic procedures, to control the effect of therapeutic measures, and to select patients with a limited prognosis by assessing the degree of ventricular dysfunction and the extent of myocardial scarring.
- Published
- 2011
- Full Text
- View/download PDF
27. Shear Wave Ultrasound Elastographic Evaluation of the Rotator Cuff Tendon
- Author
-
Stephanie W, Hou, Alexander N, Merkle, James S, Babb, Robert, McCabe, Soterios, Gyftopoulos, and Ronald S, Adler
- Subjects
Adult ,Male ,Rotator Cuff ,Young Adult ,Shoulder Pain ,Elasticity Imaging Techniques ,Humans ,Reproducibility of Results ,Female ,Middle Aged ,Aged ,Retrospective Studies ,Rotator Cuff Injuries - Abstract
(1) Assess the association between the B-mode morphologic appearance and elasticity in the rotator cuff tendon using shear wave elastography (SWE). (2) Assess the association between SWE and symptoms.Institutional Review Board approval and informed consent were obtained. A retrospective review identified 21 studies in 19 eligible patients for whom SWE was performed during routine sonographic evaluations for shoulder pain. Evaluations were compared with 55 studies from 16 asymptomatic volunteers and 6 patients with asymptomatic contralateral shoulders. Repeated studies were accounted for by resampling. Proximal and distal tendon morphologic characteristics were graded from 1 to 4 (normal to full-thickness tear), and average shear wave velocity (SWV) measurements were obtained at both locations. In 68 examinations, deltoid muscle SWV measurements were available for post hoc analysis.The morphologic grade and SWV showed weak-to-moderate negative correlations in the proximal (P .001) and distal (P = .002) rotator cuff tendon. A weakly significant SWV decrease was found in the proximal tendon in symptomatic patients (P = .049); no significant difference was seen in the distal tendon. The deltoid muscle SWV showed weak-to-moderate negative correlations with the morphologic grade in the proximal (P = .004) and distal (P = .007) tendon; the deltoid SWV was also significantly lower in symptomatic shoulders (P = .001).Shear wave elastography shows tendon softening in rotator cuff disease. It captures information not obtained by a morphologic evaluation alone; however, a poor correlation with symptoms suggests that SWE will be less useful in workups for shoulder pain than for preoperative assessments of tendon quality. Deltoid muscle softening seen in morphologically abnormal and symptomatic patients requires further exploration.
- Published
- 2015
28. Dipole analysis of magnetoencephalographic data during continuous shape copying
- Author
-
Scott M. Lewis, Frederick J. P. Langheim, Arthur C. Leuthold, Apostolos P. Georgopoulos, and Alexander N. Merkle
- Subjects
Adult ,Male ,genetic structures ,Models, Neurological ,Posterior parietal cortex ,Fixation, Ocular ,Feedback ,medicine ,Humans ,Computer vision ,Cerebral Cortex ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Subtraction ,Magnetoencephalography ,Eye movement ,Dipole ,Visual cortex ,medicine.anatomical_structure ,Pattern Recognition, Visual ,Fixation (visual) ,Female ,Artificial intelligence ,business ,Psychology ,Neuroscience ,Color Perception ,Photic Stimulation ,Psychomotor Performance ,Motor cortex - Abstract
High density, whole head magnetoencephalography (MEG) was used to study ten healthy human subjects (five females and five males) participating in a continuous shape-copying task. The task was performed with eyes open and fixated. The three-part task began with 45 s of fixation on a blue dot, after which the dot turned red, and a pentagon was presented around it. Subjects continued to fixate on the red dot for 45 s, after which it turned green. The green dot instructed subjects to begin copying the shape continuously for 45 s, without visual feedback, using a joystick mounted at arm's length. Data were collected at 1,017.25 Hz with a 248 sensor axial-gradiometer system. After cardiac artifact subtraction (Leuthold 2003), each corner was identified, and 1 s epochs (centered on each corner) were averaged and filtered from 1 to 44 Hz. Grand average flux maps demonstrated dipolar distributions identifying the most relevant sensors. With these sensors, which were located over flux extrema (Valaki et al. 2004), dipole models were used for source localization within subjects. Consistent dipole locations included the left motor cortex, bilateral parietal, frontal and temporal regions, and the occipital cortex. These results indicate that MEG source-localization may be derived from a limited number of trials of continuous data, and that visual cortex activity may be consistently present during continuous motor activity despite the absence of novel visual stimulation and eye-movements.
- Published
- 2005
- Full Text
- View/download PDF
29. Gefäßwandimaging mittels Magnetresonanztomographie
- Author
-
N. Merkle and V. Hombach
- Published
- 2005
- Full Text
- View/download PDF
30. Magnetoencephalographic signals predict movement trajectory in space
- Author
-
Alexander N. Merkle, Arthur C. Leuthold, Frederick J. P. Langheim, and Apostolos P. Georgopoulos
- Subjects
Time Factors ,Correlation coefficient ,Implanted electrodes ,Movement ,Linear summation ,Space (mathematics) ,Predictive Value of Tests ,medicine ,Humans ,Congruence (manifolds) ,Mathematics ,Brain Mapping ,Communication ,medicine.diagnostic_test ,business.industry ,Movement (music) ,General Neuroscience ,Brain ,Magnetoencephalography ,Reproducibility of Results ,Electroencephalography ,Pattern recognition ,Trajectory ,Artificial intelligence ,business ,Psychomotor Performance - Abstract
Brain-machine interface (BMI) efforts have been focused on using either invasive implanted electrodes or training-extensive conscious manipulation of brain rhythms to control prosthetic devices. Here we demonstrate an excellent prediction of movement trajectory by real-time magnetoencephalography (MEG). Ten human subjects copied a pentagon for 45 s using an X-Y joystick while MEG signals were being recorded from 248 sensors. A linear summation of weighted contributions of the MEG signals yielded a predicted movement trajectory of high congruence to the actual trajectory (median correlation coefficient: r = 0.91 and 0.97 for unsmoothed and smoothed predictions, respectively). This congruence was robust since it remained high in cross-validation analyses (based on the first half of data to predict the second half; median correlation coefficient: r = 0.76 and 0.85 for unsmoothed and smoothed predictions, respectively).
- Published
- 2005
- Full Text
- View/download PDF
31. Improving Outcomes for Diabetic Patients Undergoing Vascular Surgery
- Author
-
Thomas E. Wasser, Larry N Merkle Md, Angela Hesener Quinn, Deborah Swavely, Eric Wilson, Sallie Urffer, Joyce Najarian, and Mark J. Young
- Subjects
medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Certified diabetes educator ,Perioperative ,Vascular surgery ,medicine.disease ,Glucose management ,Diabetes mellitus ,Health care ,Internal Medicine ,Medicine ,In patient ,business ,Intensive care medicine ,Order set - Abstract
Improving management of inpatients with diabetes undergoing vascular surgery requires collaboration among many health care practitioners. This article describes a performance improvement project that implemented two evidence-based algorithmic order sets to guide perioperative glucose management for diabetic patients undergoing vascular procedures and utilized a certified diabetes educator (CDE) to educate health care practitioners. Results showed statistically and clinically significant reductions in infection and differences in mean blood glucose between pre- and postintervention groups, including a direct relationship between glucose control and the level of involvement of a CDE in patient care.
- Published
- 2005
- Full Text
- View/download PDF
32. Erratum zu: Konsensusempfehlungen der DRG/DGK/DGPK zum Einsatz der Herzbildgebung mit Computertomographie und Magnetresonanztomographie
- Author
-
Holger Thiele, Meinrad Beer, H. Marholdt, Matthias Gutberlet, T. Dill, P. Hunold, Stephan Miller, Henning Steen, T. Kühne, R. Fischbach, Joachim Eichhorn, D. Messroghli, K.-F. Kreitner, M. Hoffmann, I. Paetsch, Stephan Achenbach, D. Maintz, G. Krombach, Joerg Barkhausen, Jeffrey C. Lotz, Christoph Klein, A. Huber, N. Merkle, PW Radke, Philipp Beerbaum, Samir Sarikouch, and Sohrab Fratz
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Clinical routine - Abstract
Die kardiale Schnittbilddiagnostik mit der Magnetresonanztomographie (MRT) und Computertomographie (CT) hat sich in der letzten Dekade technisch rasant weiterentwickelt. Diese Verbesserungen und die breite Verfugbarkeit moderner CT- und MRT-Systeme haben dazu gefuhrt, dass beide Verfahren regelmasig in der klinischen Routine eingesetzt werden. Dieses deutsche Konsensuspapier wurde daher gemeinsam von der Deutschen Gesellschaft fur Kardiologie – Herz- und Kreislaufforschung (DGK), der Deutschen Rontgengesellschaft (DRG) und der Deutschen Gesellschaft fur Padiatrische Kardiologie (DGPK) erarbeitet und orientiert sich nicht an Modalitaten und Methoden, sondern gliedert sich nach grosen Krankheitsgruppen. Behandelt werden die koronare Herzerkrankung, Kardiomyopathien, Herzrhythmusstorungen, Klappenvitien, Perikarderkrankungen, erworbene und strukturellen Veranderungen sowie angeborene Herzfehler. Fur unterschiedliche klinische Szenarien werden die beiden Schnittbildmodalitaten CT und MRT vergleichend gegenubergestellt und in einem kurzen Textfeld bewertet.
- Published
- 2012
- Full Text
- View/download PDF
33. [Consensus recommendations of the German Radiology Society (DRG), the German Cardiac Society (DGK) and the German Society for Pediatric Cardiology (DGPK) on the use of cardiac imaging with computed tomography and magnetic resonance imaging]
- Author
-
S, Achenbach, J, Barkhausen, M, Beer, P, Beerbaum, T, Dill, J, Eichhorn, S, Fratz, M, Gutberlet, M, Hoffmann, A, Huber, P, Hunold, C, Klein, G, Krombach, K-F, Kreitner, T, Kühne, J, Lotz, D, Maintz, H, Mahrholdt, H, Marholdt, N, Merkle, D, Messroghli, S, Miller, I, Paetsch, P, Radke, H, Steen, H, Thiele, S, Sarikouch, and R, Fischbach
- Subjects
Adult ,Heart Defects, Congenital ,Heart Diseases ,Infant ,Prognosis ,Magnetic Resonance Imaging ,Sensitivity and Specificity ,Cardiac Imaging Techniques ,Germany ,Humans ,Interdisciplinary Communication ,Cooperative Behavior ,Child ,Tomography, X-Ray Computed - Abstract
Cardiac magnetic resonance imaging (MRI) and computed tomography (CT) have been developed rapidly in the last decade. Technical improvements and broad availability of modern CT and MRI scanners have led to an increasing and regular use of both diagnostic methods in clinical routine. Therefore, this German consensus document has been developed in collaboration by the German Cardiac Society, German Radiology Society, and the German Society for Pediatric Cardiology. It is not oriented on modalities and methods, but rather on disease entities. This consensus document deals with coronary artery disease, cardiomyopathies, arrhythmias, valvular diseases, pericardial diseases and structural changes, as well as with congenital heart defects. For different clinical scenarios both imaging modalities CT and MRI are compared and evaluated in the specific context.
- Published
- 2012
34. An efficient inverse radiotherapy planning method for VMAT using quadratic programming optimization
- Author
-
W, Hoegele, R, Loeschel, N, Merkle, and P, Zygmanski
- Subjects
Neoplasms ,Radiotherapy Planning, Computer-Assisted ,Humans ,Computer Simulation ,Radiotherapy Dosage ,Radiotherapy, Conformal ,Radiometry ,Models, Biological - Abstract
The purpose of this study is to investigate the feasibility of an inverse planning optimization approach for the Volumetric Modulated Arc Therapy (VMAT) based on quadratic programming and the projection method. The performance of this method is evaluated against a reference commercial planning system (eclipse(TM) for rapidarc(TM)) for clinically relevant cases.The inverse problem is posed in terms of a linear combination of basis functions representing arclet dose contributions and their respective linear coefficients as degrees of freedom. MLC motion is decomposed into basic motion patterns in an intuitive manner leading to a system of equations with a relatively small number of equations and unknowns. These equations are solved using quadratic programming under certain limiting physical conditions for the solution, such as the avoidance of negative dose during optimization and Monitor Unit reduction. The modeling by the projection method assures a unique treatment plan with beneficial properties, such as the explicit relation between organ weightings and the final dose distribution. Clinical cases studied include prostate and spine treatments. The optimized plans are evaluated by comparing isodose lines, DVH profiles for target and normal organs, and Monitor Units to those obtained by the clinical treatment planning system eclipse(TM).The resulting dose distributions for a prostate (with rectum and bladder as organs at risk), and for a spine case (with kidneys, liver, lung and heart as organs at risk) are presented. Overall, the results indicate that similar plan qualities for quadratic programming (QP) and rapidarc(TM) could be achieved at significantly more efficient computational and planning effort using QP. Additionally, results for the quasimodo phantom [Bohsung et al., "IMRT treatment planning: A comparative inter-system and inter-centre planning exercise of the estro quasimodo group," Radiother. Oncol. 76(3), 354-361 (2005)] are presented as an example for an extreme concave case.Quadratic programming is an alternative approach for inverse planning which generates clinically satisfying plans in comparison to the clinical system and constitutes an efficient optimization process characterized by uniqueness and reproducibility of the solution.
- Published
- 2012
35. [The role of cardiovascular magnetic resonance imaging in the diagnosis and prognosis of patients with heart failure]
- Author
-
V, Hombach, N, Merkle, V, Rasche, P, Bernhardt, and W, Rottbauer
- Subjects
Heart Failure ,Myocardial Infarction ,Humans ,Magnetic Resonance Imaging, Cine ,Prognosis - Abstract
Cardiovascular magnetic resonance (CMR) imaging is a tomographic technique, which allows three-dimensional slice orientation without limitations from acoustic windows inherent to echocardiography. Further advantages of CMR are its high temporal and spatial resolution, its excellent soft tissue resolution and its high blood-to-tissue contrast. Cardiovascular magnetic resonance is currently the only imaging technique, which provides a comprehensive study of both structure and function of the heart as well as myocardial perfusion and viability. Moreover, post-processing of CMR images does not require any geometric assumptions as in echocardiography to determine ventricular dimensions. This is particularly important when evaluating ventricles of patients with chronic heart failure with severely altered morphology that may have regional variations in wall thickness and contractility at least in ischemic cardiomyopathy. The highly reproducible results of CMR imaging have turned this technique into a reference standard for the non-invasive assessment of ventricular dimensions, mass and function. In cases with indeterminate results of clinical, electrocardiographic and particularly echocardiographic findings CMR should be used early in the process of diagnosis of patients with heart failure. Not only can altered structure and degree of ventricular and valvular dysfunctions be accurately assessed but also regional perfusion deficits and/or myocardial scars are easily detected. For therapeutic and prognostic reasons a simple differentiation between ischemic and non-ischemic cardiomyopathy should be achieved as the first diagnostic step. In addition, the type and localization of the late gadolinium enhancement (LGE) phenomenon may aid in non-invasively differentiating the etiology of non-ischemic cardiomyopathy. CMR may also improve the assessment and extent of interventricular and intraventricular dyssynchrony in patients to be selected for cardiac resynchronization therapy (CRT). Lastly, the LGE phenomenon may provide independent prognostic information in patients with a CRT system implanted, as well as in patients with ischemic and non-ischemic cardiomyopathy. Thus, CMR imaging should be implemented early in the diagnostic process of patients with heart failure to significantly improve the speed and accuracy of diagnostic procedures, to control the effect of therapeutic measures, and to select patients with a limited prognosis by assessing the degree of ventricular dysfunction and the extent of myocardial scarring.
- Published
- 2011
36. Effect of sex hormones on neuromuscular control patterns during landing
- Author
-
Jean-Michel Brismée, Phillip S. Sizer, Gregory S. Dedrick, C. Roger James, Troy R. Hounshell, Jacalyn J. Robert-McComb, Steven F. Sawyer, and Jennifer N. Merkle
- Subjects
Adult ,medicine.medical_specialty ,Time Factors ,Knee Joint ,medicine.drug_class ,media_common.quotation_subject ,Biophysics ,Neuroscience (miscellaneous) ,Luteal phase ,Motor Activity ,Weight-Bearing ,Sex hormone-binding globulin ,Internal medicine ,Follicular phase ,medicine ,Humans ,Semitendinosus muscle ,Gonadal Steroid Hormones ,Muscle, Skeletal ,Menstrual cycle ,Menstrual Cycle ,media_common ,biology ,business.industry ,Electromyography ,musculoskeletal system ,biology.organism_classification ,Valgus ,Endocrinology ,Lower Extremity ,Estrogen ,biology.protein ,Female ,Neurology (clinical) ,business ,Hormone ,Muscle Contraction - Abstract
The purpose of the study was to investigate the effects of sex hormones across menstrual cycle phases on lower extremity neuromuscular control patterns during the landing phase of a drop jump. A repeated-measures design was utilized to examine sex hormone effects in 26 recreationally active eumenorrheic women. Varus/valgus knee angle and EMG activity from six lower extremity muscles were recorded during three drop jumps from a 50 cm platform in each phase of the menstrual cycle. Blood assays verified sex hormone levels and cycle phase. The semitendinosus muscle exhibited onset delays (p ⩽ 0.006) relative to ground contact during the luteal phase, and demonstrated a significant (p ⩽ 0.05) difference between early and late follicular phases. Muscle timing differences between the gluteus maximus and semitendinosus were decreased (p ⩽ 0.05) in the luteal compared to early follicular phases. These results suggest a different co-contractive behavior between the gluteus maximus and semitendinosus, signifying a shift in neuromuscular control patterns. It appears that female recreational athletes utilize a different neuromuscular control pattern for performing a drop jump sequence when estrogen levels are high (luteal phase) compared to when they are low (early follicular phase).
- Published
- 2006
37. MR Imaging Findings in the Reticular Formation in Siblings withMPV17-Related Mitochondrial Depletion Syndrome
- Author
-
David Nascene, A. N. Merkle, and Alexander M. McKinney
- Subjects
Male ,Pathology ,medicine.medical_specialty ,business.industry ,Reticular Formation ,Siblings ,Infant, Newborn ,Infant ,Membrane Proteins ,Case Reports ,Reticular formation ,Magnetic Resonance Imaging ,Mitochondrial depletion ,Mr imaging ,Proton mr spectroscopy ,Mitochondrial Proteins ,Hepatic Encephalopathy ,medicine ,Humans ,Female ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) ,MPV17 ,business - Abstract
SUMMARY: Hepatocerebral MPV17 -MDS is quite rare (
- Published
- 2011
- Full Text
- View/download PDF
38. [Problems with the stoma. How you can advise your patients]
- Author
-
N, Merkle
- Subjects
Patient Care Team ,Postoperative Care ,Reoperation ,Postoperative Complications ,Patient Education as Topic ,Ileostomy ,Colostomy ,Humans - Abstract
Stoma management is associated with various problems, depending on the type and location of the stoma and on the individual situation. Besides such general problems as smell, flatulence and local skin problems, typical surgical complications such as retraction and stenosis, prolaps and peristomal hernia are of major relevance. Many of these problems can be avoided by careful placement of the stoma and a meticulous surgical technique. Where indicated, the surgical correction of a problem is usually not very difficult, and is most helpful for the patient.
- Published
- 2001
39. Frasier syndrome
- Author
-
Larry N. Merkle, Sheldon H. Linn, Joseph C. Guzzo, Russell B. Puschak, and Edwin Lee
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,General Medicine - Abstract
To present the case of a 17-year-old girl with primary amenorrhea and a history of hypertension since age 13 years.The patient's clinical, laboratory, and radiologic data were summarized, and features of Frasier syndrome and Drash syndrome were compared.The patient's weight was 126 kg, height was 185 cm, and blood pressure was 150/100 mm Hg. She had minimal breast budding and scant pubic hair. Laboratory data were compatible with hypergonadotropic hypogonadism. An ultrasound study of the pelvis revealed an infantile uterus and a questionable right gonad. The patient also had nephrotic-range proteinuria in conjunction with decreased creatinine clearance and normal findings on ultrasonography of the kidneys. A karyotype photomicrograph showed a male 46,XY chromosomal pattern. Although the patient's chronologic age was 17 years, her bone age was 12 1/2 years.The patient was diagnosed as having Frasier syndrome. She underwent removal of a left-sided ovary and a right adnexal mass, and her condition is well controlled with lisinopril (10 mg daily) and estrogen therapy.
- Published
- 1996
40. [The direct demonstration of a pleuroperitoneal fistula by peritoneography in a secondary Budd-Chiari syndrome]
- Author
-
W, Wrazidlo, H J, Brambs, N, Merkle, W, Lederer, and S, Schneider
- Subjects
Adult ,Radiography ,Fistula ,Ascites ,Humans ,Female ,Budd-Chiari Syndrome ,Peritoneum ,Pleural Diseases ,Peritoneal Diseases - Published
- 1993
41. [An unclear abdominal tumor. Non-Hodgkin lymphoma of the small intestine, Burkitt type, Musshoff stage II.1]
- Author
-
M, Uhl, T, Roeren, and N, Merkle
- Subjects
Adult ,Diagnosis, Differential ,Male ,Abdominal Neoplasms ,Intestinal Neoplasms ,Intestine, Small ,Humans ,Tomography, X-Ray Computed ,Burkitt Lymphoma - Published
- 1991
42. P2942 SSFP magnetic resonance imaging allows visual assessment of coronary perfusion
- Author
-
N Merkle
- Subjects
Nuclear magnetic resonance ,medicine.diagnostic_test ,business.industry ,Visual assessment ,medicine ,Magnetic resonance spectroscopic imaging ,Magnetic resonance imaging ,Steady-state free precession imaging ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Published
- 2003
- Full Text
- View/download PDF
43. Kommentar auf Anforderung der Schriftleitung
- Author
-
N. Merkle
- Subjects
medicine.medical_specialty ,business.industry ,Vascular surgery ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Transplant surgery ,Cardiothoracic surgery ,030220 oncology & carcinogenesis ,medicine ,030211 gastroenterology & hepatology ,business ,Abdominal surgery - Published
- 1997
- Full Text
- View/download PDF
44. Case in Point
- Author
-
Edwin Lee Md and Larry N Merkle Md
- Subjects
medicine.medical_specialty ,Point (typography) ,business.industry ,Medicine ,General Medicine ,business ,medicine.disease ,Acanthosis nigricans ,Dermatology - Published
- 1994
- Full Text
- View/download PDF
45. Die Rolle des Komplements bei der experimentell induzierten Pankreatitis
- Author
-
N. Merkle, R. Burk, Ch. Herfarth, J. Horn, and B. Heymer
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,Surgery ,business - Abstract
Anhand von zwei verschiedenen operativen Versuchsmodellen (distale Choledochusligatur; Pfeffersches Modell in der Modifikation von Nevalainen) soll die Bedeutung des Komplementsystems bei der Entstehung der akuten Pankreatitis tierexperimentell untersucht werden. Es konnte gezeigt werden, das auch bei nicht immunologisch induzierter akuter Pankreatitis eine Komplementdepression festgestellt werden kann. Ferner wurde gezeigt, das auch nach vorausgegangener Dekomplementierung durch Anwendung der genannten Versuchsmodelle eine akute Pankreatitis zu induzieren ist, jedoch von deutlich geringerem Ausmas. Es wird gefolgert, das das Komplementsystem wesentlich an der Progredienz und Intensitat des entzundlichen Geschehens Anteil hat.
- Published
- 1980
- Full Text
- View/download PDF
46. Der reduzierte Ern�hrungszustand des chirurgischen Tumorpatienten ?Ein Risikofaktor f�r postoperative Komplikationen?
- Author
-
J. E. Schmitz, A. Grünert, N. Merkle, and Ch. Herfarth
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Cardiothoracic surgery ,medicine ,Surgery ,business ,Abdominal surgery - Abstract
Dem Ernahrungszustand als allgemeinem Risikofaktor wird in neuerer Zeit mehr Beachtung geschenkt. Bei 100 Patienten mit soliden operablen Tumoren wurde eine ausfuhrliche Erhebung des Ernahrungszustandes durchgefuhrt (Anamnese, KG, OKG, Tricepshautfaltenmessung THF, Armmuskelumfangsmessung AMU, Kreatininindex KI, Protein- und Albuminbestimmung im Serum, Praalbumin, Cholinesterase, Transferrin, Immunstatus). Das individuelle Defizit des Ernahrungszustandes wurde mit Hilfe eines einfachen Systems quantifiziert und mit dem Auftreten postoperativer Komplikationen verglichen. Bei 32 von 95 operierten Patienten traten Komplikationen auf. Diese nahmen mit einer Verschlechterung des Ernahrungszustandes zu. Ein statistisch signifikanter Zusammenhang zwischen einzelnen Mesgrosen und dem Vorhandensein bzw. Fehlen von postoperativen Komplikationen lies sich allerdings nicht nachweisen. Mogliche Zusammenhange werden diskutiert.
- Published
- 1985
- Full Text
- View/download PDF
47. Zur Bedeutung des Ern�hrungsstatus chirurgischer Patienten
- Author
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Ch. Herfarth, A. Grnert, N. Merkle, and J. E. Schmitze
- Subjects
business.industry ,Medicine ,Surgery ,business - Published
- 1985
- Full Text
- View/download PDF
48. Ergebnisse nach operativer Behandlung von Patellafrakturen
- Author
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M. Betzler, E. Eibelshäuser, F. Pankarter, and N. Merkle
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,business - Abstract
An der Abteilung fur Unfallchirurgie, Plastische und Wiederherstellungschirurgie der Universitat Ulm wurden in den Jahren 1971 bis 1976 neunzig erwachsene Patienten wegen Patellafrakturen operativ behandelt. Davon konnten 68 durchschnittlich 42 Monate postoperativ klinisch und rontgenologisch nachuntersucht werden. Das Krankengut bestand aus 50 mannlichen und 18 weiblichen Patienten — mit insgesamt 71 Patellafrakturen. Das Durchschnittsalter betrug 38,7 Jahre bei den Mannern und 45,5 Jahre bei den Frauen. Vorwiegende Unfallursachen waren Verkehrsunfalle (65%) und Arbeitsunfalle (19%). Die rechte Kniescheibe war mehr als doppelt so oft betroffen wie die linke. Dreimal lagen beidseitige Frakturen vor. In 49% der Falle handelte es sich um Trummerfrakturen, in 38% um offene Frakturen. Bei der Behandlung kamen vorwiegend die alleinige ventrale Zuggurtung oder die Zuggurtung in Kombination mit Kirschnerdrahten oder Schrauben zur Anwendung. — Ergebnisse: 93% der Nachuntersuchten wiesen bei der Kontrolle wieder seitengleiche Streckfahigkeit des Kniegelenkes auf, 7% einen Streckausfall von weniger als 10°. Seitengleiche Beugung hatten 56% der Untersuchten erreicht; 24% boten ein Beugedefizit bis zu 10°, 10% bis zu 20° und weitere 10% uber 20°. Arthrosezeichen irgendwelcher Art im Bereich des betroffenen Kniegelenkes konnten ohne Berucksichtigung des Vorzustandes in 46% gefunden werden. Eine Verschmachtigung der Beinmuskulatur wiesen noch 43% der Untersuchten auf. Postoperativ traten zweimal Thrombosen (einmal oberflachlich, einmal tief) auf. Einmal bildete sich eine Hautnekrose im Bereich der Operationswunde. Der entstandene Gewebsdefekt wurde plastisch gedeckt. Bei zwei Fallen kam es im Anschlus an die Versorgung von Trummerfrakturen zu einer Infektion. Postoperative Gelenksergusse fanden sich dreimal. Viermal kam es zum Auftreten sekundarer Dislokationen. Bei zwei Frakturen entstand eine Pseudarthrose, davon konnte eine durch Fixateur externe zur Ausheilung gebracht werden, die zweite wurde wegen praktischer Beschwerdefreiheit belassen. Unsere Ergebnisse zeigen, das die Versorgung der Patellafrakturen nach dem Zuggurtungsprinzip mit fruhfunktioneller Nachbehandlung die erreichbaren Ergebnisse zu verbessern vermogen, das aber bei dieser Frakturlokalisation die Rate der folgenlosen Ausheilungen gegenuber anderen Korperregionen geringer ist.
- Published
- 1979
- Full Text
- View/download PDF
49. Die chirurgische Papillenplastik ?endoskopisch-manometrische und klinische Befunde
- Author
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Th. Heil, N. Merkle, D. Belohlavek, and E. U. Voss
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Cardiothoracic surgery ,business.industry ,medicine ,Surgery ,Vascular surgery ,business ,Abdominal surgery ,Endoscopy ,Cardiac surgery - Abstract
49 Patienten, bei denen 4–9 Jahre vor der Nachuntersuchung eine transduodenale Papillenplastik durchgefuhrt worden war, konnten einer endoskopisch-manometrischen Kontrolle des Operationsergebnisses zugefuhrt werden.
- Published
- 1978
- Full Text
- View/download PDF
50. Erfahrungen mit einem einfachen Schema zur Beurteilung eines ernährungsbedingten Operationsrisikos
- Author
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N. Merkle, E. Heinz, J.E. Schmitz, A. Grünert, F.W. Ahnefeld, and S. Berg
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Immunology and Allergy ,Hematology ,business - Abstract
Zur Erfassung eines evtl. bestehenden ernährungsbedingten Operationsrisikos sowie eines sich daraus bereits frühzeitig ableitenden Konzepts einer adäquaten Ernährungsbehandlung wird ein »einfaches Schema« dargestellt, das sich wie die vielfach in der Literatur angegeben, wesentlich aufwendigeren Dokumentationen zur Definition des Ernährungsstatus eignet. Zur genauen Protokollierung sowie zur Verlaufsbeurteilung als auch zur Erstellung prognostischer Angaben eignet sich dieses Schema jedoch nicht. Sollten sich bei der Auswertung des »einfachen Schemas« Hinweise für ein möglicherweise bestehendes ernährungsbedingtes zusätzliches Operationsrisiko ergeben, so sind zur Differenzierung aufwendigere Untersuchungen angezeigt, urn Ursache und Ausprägung der Mangel-bzw. Fehlernährung zu präzisieren.
- Published
- 1983
- Full Text
- View/download PDF
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