429 results on '"N?thlings, U"'
Search Results
2. Substitution von Milchprodukten durch angereicherte und nicht angereicherte pflanzenbasierte Alternativen: Modellanalyse zu Auswirkungen auf die Nährstoffzufuhr und ökologische Nachhaltigkeit bei deutschen Kindern und Jugendlichen
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Hohoff, E, Alexy, U, van de Locht, K, Nöthlings, U, Hohoff, E, Alexy, U, van de Locht, K, and Nöthlings, U
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- 2024
3. Vergleich von hypothesen- und datengetriebenen Endpunktscores bei jungen Erwachsenen - eine Analyse in der DONALD Studie
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Mark, M, Conzen, CA, Alexy, U, Nöthlings, U, Mark, M, Conzen, CA, Alexy, U, and Nöthlings, U
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- 2024
4. Characterization of dietary intake trajectories throughout childhood, adolescence, and young adulthood in the DONALD study
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Conzen, CA, Alexy, U, Nöthlings, U, Conzen, CA, Alexy, U, and Nöthlings, U
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- 2024
5. Association of a Lifestyle Risk Index with Visceral Adipose Tissue and Diabetes in the NAKO
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Maskarinec, G, Klapp, R, Nöthlings, U, Sedlmeier, A, Schulze, MB, Nattenmüller, J, Bamberg, F, Haueise, T, Machann, J, Nauck, M, Nimptsch, K, Pischon, T, Maskarinec, G, Klapp, R, Nöthlings, U, Sedlmeier, A, Schulze, MB, Nattenmüller, J, Bamberg, F, Haueise, T, Machann, J, Nauck, M, Nimptsch, K, and Pischon, T
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- 2024
6. Optimised diets for achieving One Health: A pilot study in the Rhine-Ruhr Metropolis in Germany
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Minetto Gellert Paris, J., Escobar Lanzuela, N., Falkenberg, T., Gupta, S., Heinzel, C., Verly Junior, E., Jolliet, O., Borgemeister, C., Nöthlings, U., Minetto Gellert Paris, J., Escobar Lanzuela, N., Falkenberg, T., Gupta, S., Heinzel, C., Verly Junior, E., Jolliet, O., Borgemeister, C., and Nöthlings, U.
- Abstract
Dietary changes are needed to align the global food systems with the planetary boundaries and contribute to Sustainable Development Goals. We employed a Life Cycle Assessment (LCA) framework, extended with indicators on human health and animal welfare, to assess 2020 food consumption data of a pilot sample collected through an online survey in the Rhine-Ruhr Metropolis (Germany). Feasible optimisation scenarios representing alternative sustainable choices towards overarching environmental, societal and policy goals were explored. Meat and meat products contributed most to overall environmental impacts (e.g., climate change, terrestrial acidification), and fish and seafood to animal welfare loss (e.g., animal lives lost, animal life years suffered). Sodium intake was the most contributing risk factor for life minutes lost. The combined optimisation scenario reduces 55% of greenhouse gas emissions, improves human health indicators by 25% and reduces animal welfare loss substantially (by 52-97%). This is possible with a shift towards flexitarian and vegetarian dietary scenarios. These optimisations deliver improvements across One Health dimensions with marginal changes in dietary scenarios and align with the sustainability goals of the EU Green Deal. Working with regional data can offer advantages in obtaining more realistic baseline dietary information to promote localised dietary shifts. While this research has limitations regarding sample representativeness, it can serve as a case study to encourage sustainable consumption in the Rhine-Ruhr region.
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- 2024
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7. Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation
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Hüser, S., Guth, S., Joost, H. G., Soukup, S. T., Köhrle, J., Kreienbrock, L., Diel, P., Lachenmeier, D. W., Eisenbrand, G., Vollmer, G., Nöthlings, U., Marko, D., Mally, A., Grune, T., Lehmann, L., Steinberg, P., and Kulling, S. E.
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- 2018
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8. Neue Sorgfaltspflichten für Unternehmen des Agrar- und Ernährungssektors : Empfehlungen zu aktuellen Gesetzesentwicklungen
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Wieck, C., Spiller, A., Nieberg, H., Rudloff, B., Iweala, S., Balmann, A., Birner, R., Bosy-Westphal, A., Buyken, A., Döring, T., Feindt, P., Götz, K.U., Linseisen, J., Martínez, J., Nöthlings, U., Pischetsrieder, M., Renner, B., Voget-Kleschin, L., Weingarten, P., Wesseler, J.H.H., Wieck, C., Spiller, A., Nieberg, H., Rudloff, B., Iweala, S., Balmann, A., Birner, R., Bosy-Westphal, A., Buyken, A., Döring, T., Feindt, P., Götz, K.U., Linseisen, J., Martínez, J., Nöthlings, U., Pischetsrieder, M., Renner, B., Voget-Kleschin, L., Weingarten, P., and Wesseler, J.H.H.
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- 2023
9. Perspektiven für die Ernährungsforschung 2022: Position der Deutschen Gesellschaft für Ernährung e. V
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Linseisen, Jakob, Buyken, A., Watzl, B., Ellrott, T., Grune, T., Hauner, H., Heseker, H., Kulling, S. E., Nöthlings, U., Stangl, G., Conrad, J., Tauer, J., and Virmani, K.
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ddc:610 - Published
- 2023
10. Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
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Koch, M, Freitag-Wolf, S, Schlesinger, S, Borggrefe, J, Hov, J R, Jensen, M K, Pick, J, Markus, M R P, Höpfner, T, Jacobs, G, Siegert, S, Artati, A, Kastenmüller, G, Römisch-Margl, W, Adamski, J, Illig, T, Nothnagel, M, Karlsen, T H, Schreiber, S, Franke, A, Krawczak, M, Nöthlings, U, and Lieb, W
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- 2017
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11. NFDI4Health – nationale Forschungsdateninfrastruktur für personenbezogene Gesundheitsdaten
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Fluck, J., Lindstädt, B., Ahrens, W., Beyan, O., Buchner, B., Darms, J., Depping, R., Dierkes, J., Fröhlich, H., Gehrke, J., Golebiewski, M., Grabenhenrich, L., Hahn, H.K., Kirsten, T., Klammt, S., Kusch, H., Löbe, M., Löffler, M., Meineke, F., Müller, W., Neuhausen, H., Nöthlings, U., Pischon, T., Prasser, F., Sax, U., Schmidt, C.O., Schulze, M., Semler, S.C., Thun, S., Waltemath, D., Wieler, L.H., Zeeb, H., Pigeot, I., and Publica
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Cardiovascular and Metabolic Diseases ,ddc:340 - Abstract
Epidemiologische und klinische Studien sind standardisiert und gut dokumentiert, jedoch erfüllen Studienprotokolle, eingesetzte Erhebungsinstrumente und erhobene Daten die Anforderungen der FAIR-Prinzipien nicht in ausreichendem Maße. NFDI4Health wird daher eine Struktur schaffen, die eine zentrale Suche nach existierenden, dezentral verwalteten Datenkörpern und zugehörigen Dokumenten sowie einen FAIRen Zugang zu diesen erleichtert. Dazu werden die Auffindbarkeit und der Zugang zu strukturierten Gesundheitsdaten aus Registern, administrativen Gesundheitsdatenbanken, klinischen und epidemiologischen sowie Public Health-Studien verbessert und die Qualität und Harmonisierung der zugrundeliegenden Daten optimiert. Eine weitere Herausforderung entsteht durch die Verwendung personenbezogener Gesundheitsdaten. Diese sind hoch sensibel, so dass ihre Nutzung restriktive Datenschutzbestimmungen und informierte Einwilligungserklärungen der StudienteilnehmerInnen erfordert, was jedoch ihre Wiederverwendbarkeit einschränkt. NFDI4Health zielt daher darauf ab, den Austausch und die Verknüpfung von personenbezogenen Gesundheitsdaten sowie verteilte Datenanalysen unter Einhaltung datenschutzrechtlicher und ethischer Bestimmungen zu erleichtern. Um dies möglichst effizient zu erreichen, wird NFDI4Health die Entwicklung neuer, maschinenprozessierbarer Zustimmungsmöglichkeiten sowie innovativer Datenzugriffsservices auf Grundlage der FAIRPrinzipien vorantreiben und die Interoperabilität von IT-Lösungen für Metadatenrepositorien stärken. Komplementiert wird dies durch die Entwicklung entsprechender Angebote für Training und Ausbildung, um der Herausforderung der Umsetzung der Lösungen in den Universitäten und Forschungseinrichtungen zu begegnen. Schließlich wird durch die gemeinsame Arbeit in der NFDI4Health die Kooperation zwischen klinischer und epidemiologischer/Public Health-Forschung gestärkt.
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- 2022
12. Changes in body weight and obesity status in German adults: results of seven population-based prospective studies
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Haftenberger, M., Mensink, G.B.M., Herzog, B., Kluttig, A., Greiser, K.H., Merz, B., Nothlings, U., Schlesinger, S., Vogt, S., Thorand, B., Peters, A., Ittermann, T., Volzke, H., Schipf, S., Neamat-Allah, J., Kuhn, T., Kaaks, R., Boeing, H., Bachlechner, U., Scheidt-Nave, C., and Schienkiewitz, A.
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Obesity -- Physiological aspects ,Body weight -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
BACKGROUND/OBJECTIVES: The objective of this study was to quantify body weight changes in German adult populations during the past decades. SUBJECTS/METHODS: Longitudinal analysis of seven cohort studies covering different age ranges between 18 and 83 years. Baseline examinations were between 1994 and 2007 and follow-up durations between 4.0 and 11.9 years. For each study, mean change in body weight per year and 10-year change in body mass index (BMI) classification were analyzed. For the middle age group of 45-64 years, meta-analysis was conducted to obtain an overall estimate for Germany. RESULTS: Among men weight gain was highest in the youngest participants and decreased with advancing age. Among women weight gain was on a stable high level among those younger than 45 years and decreased at older age. Within 10 years, 30-40% of middle-aged participants with normal baseline weight became pre-obese or obese and 20-25% of those with pre-obesity at baseline became obese, whereas >80% of persons who were obese at baseline remained obese over time. The estimated average weight change in adults aged 45-64 years was 0.25 (95% confidence interval (CI): 0.18-0.33) kg/year among men and 0.24 (0.17-0.30) kg/year among women. CONCLUSIONS: We could observe a moderate weight gain over the past years in German middle-aged populations of 0.25 kg/year. Obesity prevention needs to be targeted to specific subgroups in the population, especially to younger adults, who seem to be most vulnerable for gaining weight. Obesity intervention needs to be improved, as the majority of obese adults remained obese over time. European Journal of Clinical Nutrition (2016) 70, 300-305; doi: 10.1038/ejcn.2015.179; published online 28 October 2015, INTRODUCTION During the past decades, the prevalence of overweight (body mass index, BMI [greater than or equal to] 25.0 kg/[m.sup.2]) and obesity (BMI [greater than or equal to] 30.0 kg/[m.sup.2]) [...]
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- 2016
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13. Research priorities for sustainability science. Position paper
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Jacob, D., Birkmann, J., Bollig, M., Bonn, Aletta ; orcid:0000-0002-8345-4600, Nöthlings, U., Ott, K., Quaas, M., Reichstein, M., Scholz, I., Malburg-Graf, B., Sonntag, S., Jacob, D., Birkmann, J., Bollig, M., Bonn, Aletta ; orcid:0000-0002-8345-4600, Nöthlings, U., Ott, K., Quaas, M., Reichstein, M., Scholz, I., Malburg-Graf, B., and Sonntag, S.
- Abstract
With this position paper the DKN highlights pertinent research gaps and suggests forthcoming fields of research. It combines insights from global environmental change research and the environmental social sciences and humanities. This programmatic framework will form the basis of the future work program of the committee itself. Furthermore, it is hoped that it will motivate other scientists to engage across disciplinary boundaries with the manifold epistemological, theoretical, and methodological challenges of sustainability science. This contribution addresses agents in science, science management, and science funding in a national and an international context.
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- 2022
14. Changing dietary patterns is necessary to improve the sustainability of Western diets from a One Health perspective
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Paris, J.M.G., Falkenberg, T., Nöthlings, U., Heinzel, C., Borgemeister, C., Escobar Lanzuela, N., Paris, J.M.G., Falkenberg, T., Nöthlings, U., Heinzel, C., Borgemeister, C., and Escobar Lanzuela, N.
- Abstract
Western diets are associated with multiple environmental impacts and risks to human health. European countries are gradually taking action towards the Farm to Fork Strategy, embracing a Life Cycle Assessment (LCA) perspective to promote the sustainability of food production and consumption. Although LCA enables the comprehensive assessment of environmental impacts, diet-related human health and animal welfare impacts are often underrepresented. This study proposes integrating additional indicators into LCA to evaluate the sustainability of diets under the One Health (OH) approach, which holistically considers interlinked complex health issues between humans, animals and the environment. Human health loss is estimated according to risk factors for non-communicable diseases; while animal welfare is measured as animal life years suffered, loss of animal lives and loss of morally-adjusted animal lives. The extended LCA framework is applied to men and women's reference diets in the German federal state of North Rhine-Westphalia (NRW); compared to three optimized dietary scenarios under nutritional constraints: 1) the national dietary guidelines, 2) a vegan diet (VD) and 3) a Mediterranean diet (MD). Men's reference diet causes greater impacts than women's across OH dimensions due to the higher food consumption, especially of ready-to-eat meals, sausages, meat, and sweetened and alcoholic beverages. Both reference diets are associated with risk factors for cardiovascular diseases, diabetes, stroke and neoplasms. Besides meat, consumption of honey, fish and seafood has the greatest impact on animal welfare, because of the high number of individuals involved. Alternative diets improve the sustainability of food consumption in NRW, although trade-offs arise: MD worsens animal suffering due to the higher fish intake; water use increases in both VD and MD due the higher intake of nuts and vegetables. Results highlight the importance of including animal welfare and human health
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- 2022
15. Corrigendum to “Changing dietary patterns is necessary to improve the sustainability of Western diets from a One Health perspective” [Sci. Total Environ. 811 (2022)/151437]
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Paris Minetto Gellert, J., Falkenberg, T., Nöthlings, U., Heinzel, C., Borgemeister, C., Escobar, N., Paris Minetto Gellert, J., Falkenberg, T., Nöthlings, U., Heinzel, C., Borgemeister, C., and Escobar, N.
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- 2022
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16. Research priorities for sustainability science: DKN position paper
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Jacob, D., Birkmann, J., Bollig, M., Bonn, A., Nöthlings, U., Ott, K., Quaas, M., Reichstein, M., Scholz, I., Malburg-Graf, B., and Sonntag, S.
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- 2022
17. Development and evaluation of a short 24-h food list as part of a blended dietary assessment strategy in large-scale cohort studies
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Freese, J., Feller, S., Harttig, U., Kleiser, C., Linseisen, J., Fischer, B., Leitzmann, M.F., Six-Merker, J., Michels, K.B., Nimptsch, K., Steinbrecher, A., Pischon, T., Heuer, T., Hoffmann, I., Jacobs, G., Boeing, H., and Nothlings, U.
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Nutrition -- Product/Service Evaluations ,Food consumption -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
BACKGROUND/OBJECTIVES: The validity of dietary assessment in large-scale cohort studies has been questioned. Combining data sources for the estimation of usual intake in a blended approach may enhance the validity of dietary measurement. Our objective was to develop a web-based 24-h food list for Germany to identify foods consumed during the previous 24 h and to evaluate the performance of the new questionnaire in a feasibility study. SUBJECTS/METHODS: Available data from the German National Nutrition Survey II were used to develop a finite list of food items. A total of 508 individuals were invited to fill in the 24-h food list via the Internet up to three times during a 3-6-month time period. In addition, participants were asked to evaluate the questionnaire using a brief online evaluation form. RESULTS: In total, 246 food items were identified for the 24-h food list, reflecting > 75% variation in intake of 27 nutrients and four major food groups. Among the individuals invited, 64% participated in the feasibility study. Of these, 100%, 85% and 68% of participants completed the 24-h food list one, two or three times, respectively. The average time needed to complete the questionnaire was 9 min, and its acceptability by participants was rated as high. CONCLUSIONS: The 24-h food list represents a promising new dietary assessment tool that can be used as part of a blended approach combining multiple data sources for valid estimation of usual dietary intake in large-scale cohort studies. European Journal of Clinical Nutrition (2014) 68, 324-329; doi:10.1038/ejcn.2013.274; published online 8 January 2014 Keywords: nutritional epidemiology; dietary assessment; statistical modelling Keywords: nutritional epidemiology; dietary assessment; statistical modelling, INTRODUCTION The valid estimation of long-term dietary intake in large-scale cohort studies represents a methodological challenge. Food frequency questionnaires (FFQs) have long been the instrument of choice. However, FFQs measure [...]
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- 2014
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18. Feasibility and quality development of biomaterials in the pretest studies of the German National Cohort
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Kühn, A., Nieters, A., Köttgen, A., Goek, O.N., Michels, K., Nöthlings, U., Jacobs, G., Meisinger, C., Pessler, F., Akmatov, M.F., Kühnisch, J., Moebus, S., Glocker, E., Naus, S., Keimling, M., Leitzmann, M., Linseisen, J., Sarioglu, H., von Toerne, C., Hauck, S.M., Wallaschofski, H., Wichmann, H.E., and Illig, Thomas
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- 2014
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19. The validation of cardiovascular risk scores for patients with type 2 diabetes mellitus
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van der Leeuw, J, van Dieren, S, Beulens, J W J, Boeing, H, Spijkerman, A M W, van der Graaf, Y, van der A, D L, Nöthlings, U, Visseren, F L J, Rutten, G E H M, Moons, K G M, van der Schouw, Y T, and Peelen, L M
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- 2015
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20. German Sustainability Science Summit 2021 : Conference Summary Report
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Birkmann, J., Bollig, M., Bonn, A., Jacob, D., Nöthlings, U., Ott, K., Quaas, M., Reichstein, M., and Scholz, I.
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Summary: Sustainability science has become more and more important over the last years, as within times where the need for mitigation of and adaptation to climate change, the need for healthy ecosystems as well as for social cohesion and justice have become pressing issues, a sustainable transformation is of utmost urgency. The German Sustainability Science Summit 2021 continued the series of German Future Earth Summits organized by the German Committee Future Earth (DKN). In this way, the DKN provides a platform for exchange on new scientific findings and research needs in the field of sustainability research and to foster interdisciplinary collaborations within Future Earth and beyond. Future Earth is a network of scientists, researchers and innovators designed to provide the knowledge needed to support transformations towards sustainability. The focus of the summit was explicitly dedicated to national and international interdisciplinary and integrative sustainability science, while discussing the previous and future work of the DKN. Around 500 participants from 46 countries from all over the world registered for the German Sustainability Science Summit 2021. The conference was held as an online event on 8th and 9th July 2021, with about 150 participants acting as hosts and speakers of the 29 different summit sessions.The summit was preceded by an early-career researcher workshop on 7th July 2021 on opportunities and challenges for early-career scientists in inter- and trans-disciplinary sustainability science. One important item on the summit program was the discussion of the DKN position paper on central focus topics and open research questions in sustainability research. The position paper was brought forward by the DKN committee members, c oming from very different disciplines, and prior to the summit was provided to all participants. The paper comprises the focus topics which were discussed during several sessions of the summit, such as (1) Normativity in sustainability research, (2) Extreme events: collapse or resilience? - the role of health, well-being and social cohesion for reaching the sustainable development goals, (3) Diet, biodiversity and h ealth - the role of sustainable diets for healthy people and healthy ecosystems, and (4) Scale challenges in climate change, risk and adaptation research in the context of sustainable development. The lively discussions and interesting comments on the position paper will be reflected in the future work of the DKN. Most of the summit sessions were set up in response to an open call for session proposals. In addition to the various scientific sessions and science-policy sessions with presentations and lively discussions, the online conference platform enabled networking via v arious innovative tools including a poster and networking session with a virtual art exhibition. The sessions covered a broad range of topics, including climate change adaptation finance, the role of participation in just science and governance, water security, biodiversity, planning and construction, systemic risks, and others. Also the three active DKN working groups outlined their topics on (1) Modelling the human environmental interactions in the anthropocene, (2) Antici pating and transforming coastal f utures, and (3) Sustainable, transformative and circu lar bioeconomy. The diverse program was rounded up with two vivid plenary panel discussions, shedding light on the new social contract for climate change adaptation in dynamic societies and concluding the summit with perspectives of international sustainability science. The DKN thanks all panelists, speakers, presenters and participants for joining the summit, for all their contributions and for participating in the enlightening and lively discussions. Many thanks also go to the event agency Con Gressa for the technical realization of the event and for the creation of the summit logo. And last but not least, strong thanks to the German Science Foun dation (DFG), without which the summit would not have been possible.
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- 2021
21. Changing dietary patterns is necessary to improve the sustainability of Western diets from a One Health perspective
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Paris, J.M.G., Falkenberg, T., Nöthlings, U., Heinzel, C., Borgemeister, C., Escobar Lanzuela, N., Paris, J.M.G., Falkenberg, T., Nöthlings, U., Heinzel, C., Borgemeister, C., and Escobar Lanzuela, N.
- Abstract
Western diets are associated with multiple environmental impacts and risks to human health. European countries are gradually taking action towards the Farm to Fork Strategy, embracing a Life Cycle Assessment (LCA) perspective to promote the sustainability of food production and consumption. Although LCA enables the comprehensive assessment of environmental impacts, diet-related human health and animal welfare impacts are often underrepresented. This study proposes integrating additional indicators into LCA to evaluate the sustainability of diets under the One Health (OH) approach, which holistically considers interlinked complex health issues between humans, animals and the environment. Human health loss is estimated according to risk factors for non-communicable diseases; while animal welfare is measured as animal life years suffered, loss of animal lives and loss of morally-adjusted animal lives. The extended LCA framework is applied to men and women's reference diets in the German federal state of North Rhine-Westphalia (NRW); compared to three optimized dietary scenarios under nutritional constraints: 1) the national dietary guidelines, 2) a vegan diet (VD) and 3) a Mediterranean diet (MD). Men's reference diet causes greater impacts than women's across OH dimensions due to the higher food consumption, especially of ready-to-eat meals, sausages, meat, and sweetened and alcoholic beverages. Both reference diets are associated with risk factors for cardiovascular diseases, diabetes, stroke and neoplasms. Besides meat, consumption of honey, fish and seafood has the greatest impact on animal welfare, because of the high number of individuals involved. Alternative diets improve the sustainability of food consumption in NRW, although trade-offs arise: MD worsens animal suffering due to the higher fish intake; water use increases in both VD and MD due the higher intake of nuts and vegetables. Results highlight the importance of including animal welfare and human health
- Published
- 2021
22. Dietary macronutrient composition in relation to circulating HDL and non-HDL cholesterol: A federated individual-level analysis of Cross-sectional data from adolescents and adults in 8 European studies
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Pinart, M., Jeran, S., Boeing, H., Stelmach-Mardas, M., Standl, M., Schulz, H., Harris, C., von Berg, A., Herberth, Gunda, Koletzko, S., Linseisen, J., Breuninger, T.A., Nöthlings, U., Barbaresko, J., Benda, S., Lachat, C., Yang, C., Gasparini, P., Robino, A., Rojo-Martínez, G., Castaño, L., Guillaume, M., Donneau, A.-F., Hoge, A., Gillain, N., Avraam, D., Burton, P.R., Bouwman, J., Pischon, T., Nimptsch, K., Pinart, M., Jeran, S., Boeing, H., Stelmach-Mardas, M., Standl, M., Schulz, H., Harris, C., von Berg, A., Herberth, Gunda, Koletzko, S., Linseisen, J., Breuninger, T.A., Nöthlings, U., Barbaresko, J., Benda, S., Lachat, C., Yang, C., Gasparini, P., Robino, A., Rojo-Martínez, G., Castaño, L., Guillaume, M., Donneau, A.-F., Hoge, A., Gillain, N., Avraam, D., Burton, P.R., Bouwman, J., Pischon, T., and Nimptsch, K.
- Abstract
BackgroundAssociations between increased dietary fat and decreased carbohydrate intake with circulating HDL and non-HDL cholesterol have not been conclusively determined.ObjectiveWe assessed these relations in 8 European observational human studies participating in the European Nutritional Phenotype Assessment and Data Sharing Initiative (ENPADASI) using harmonized data.MethodsDietary macronutrient intake was recorded using study-specific dietary assessment tools. Main outcome measures were lipoprotein cholesterol concentrations: HDL cholesterol (mg/dL) and non-HDL cholesterol (mg/dL). A cross-sectional analysis on 5919 participants (54% female) aged 13–80 y was undertaken using the statistical platform DataSHIELD that allows remote/federated nondisclosive analysis of individual-level data. Generalized linear models (GLM) were fitted to assess associations between replacing 5% of energy from carbohydrates with equivalent energy from total fats, SFAs, MUFAs, or PUFAs with circulating HDL cholesterol and non-HDL cholesterol. GLM were adjusted for study source, age, sex, smoking status, alcohol intake and BMI.ResultsThe replacement of 5% of energy from carbohydrates with total fats or MUFAs was statistically significantly associated with 0.67 mg/dL (95% CI: 0.40, 0.94) or 0.99 mg/dL (95% CI: 0.37, 1.60) higher HDL cholesterol, respectively, but not with non-HDL cholesterol concentrations. The replacement of 5% of energy from carbohydrates with SFAs or PUFAs was not associated with HDL cholesterol, but SFAs were statistically significantly associated with 1.94 mg/dL (95% CI: 0.08, 3.79) higher non-HDL cholesterol, and PUFAs with –3.91 mg/dL (95% CI: –6.98, –0.84) lower non-HDL cholesterol concentrations. A statistically significant interaction by sex for the association of replacing carbohydrates with MUFAs and non-HDL cholesterol was observed, showing a statistically significant inverse association in males and no statistically signi
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- 2021
23. PopGen: Eine populationsbasierte Biobank mit Langzeitverfolgung der Kontrollkohorte
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Nöthlings, U. and Krawczak, M.
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- 2012
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24. Biobanken als wissenschaftliche Ressourcen: Beispiel Biobank PopGen
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Nöthlings, U. and Kohlenberg, A.
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- 2012
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25. Food intake of individuals with and without diabetes across different countries and ethnic groups
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Nöthlings, U, Boeing, H, Maskarinec, G, Sluik, D, Teucher, B, Kaaks, R, Tjønneland, A, Halkjaer, J, Dethlefsen, C, Overvad, K, Amiano, P, Toledo, E, Bendinelli, B, Grioni, S, Tumino, R, Sacerdote, C, Mattiello, A, Beulens, J W J, Iestra, J A, Spijkerman, A M W, van der A, D L, Nilsson, P, Sonestedt, E, Rolandsson, O, Franks, P W, Vergnaud, A-C, Romaguera, D, Norat, T, and Kolonel, L N
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- 2011
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26. External validation of the UK Prospective Diabetes Study (UKPDS) risk engine in patients with type 2 diabetes
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van Dieren, S., Peelen, L. M., Nöthlings, U., van der Schouw, Y. T., Rutten, G. E. H. M., Spijkerman, A. M. W., van der A, D. L., Sluik, D., Boeing, H., Moons, K. G. M., and Beulens, J. W. J.
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- 2011
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27. Non-fasting lipids and risk of cardiovascular disease in patients with diabetes mellitus
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van Dieren, S., Nöthlings, U., van der Schouw, Y. T., Spijkerman, A. M. W., Rutten, G. E. H. M., van der A, D. L., Sluik, D., Weikert, C., Joost, H. G., Boeing, H., and Beulens, J. W. J.
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- 2011
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28. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Büchner, F. L., Bueno-de-Mesquita, H. B., Linseisen, J., Boshuizen, H. C., Kiemeney, L. A. L. M., Ros, M. M., Overvad, K., Hansen, L., Tjonneland, A., Raaschou-Nielsen, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., Zylis, D., Dilis, V., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Peeters, P. H. M., van Gils, C. H., Lund, E., Gram, I. T., Braaten, T., Martinez, C., Agudo, A., Arriola, L., Ardanaz, E., Navarro, C., Rodríguez, L., Manjer, J., Wirfält, E., Hallmans, G., Rasmuson, T., Key, T. J., Roddam, A. W., Bingham, S., Khaw, K.-T., Slimani, N., Bofetta, P., Byrnes, G., Norat, T., Michaud, D., and Riboli, E.
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- 2010
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29. A micro RNA-146a polymorphism is associated with coronary restenosis
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Hamann, L., Glaeser, C., Schulz, S., Gross, M., Franke, A., Nöthlings, U., and Schumann, R. R.
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- 2014
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30. Variation in intakes of calcium, phosphorus, magnesium, iron and potassium in 10 countries in the European Prospective Investigation into Cancer and Nutrition study
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Welch, A.A., Fransen, H., Jenab, M., Boutron-Ruault, M.C., Tumino, R., Agnoli, C., Ericson, U., Johansson, I., Ferrari, P., Engeset, D., Lund, E., Lentjes, M., Key, T., Touvier, M., Niravong, M., Larranaga, N., Rodriguez, L., Ocke, M.C., Peeters, P.H.M., Tjonneland, A., Bjerregaard, L., Vasilopoulou, E., Dilis, V., Linseisen, J., Nothlings, U., Riboli, E., Slimani, N., and Bingham, S.
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Iron in the body -- Health aspects -- Research ,Chronic diseases -- Risk factors -- Research ,Potassium in the body -- Health aspects -- Research ,Calcium, Dietary -- Health aspects -- Research ,Cancer -- Risk factors ,Phosphorus in the body -- Health aspects -- Research ,Magnesium in the body -- Health aspects -- Research ,Diet -- Health aspects -- Research ,Food/cooking/nutrition ,Health - Abstract
Background/objectives: Adequate mineral intake is important for the maintenance of bone health, cellular function and general metabolism, and possibly in the aetiology of cancer and other chronic diseases. This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: Nutrient intakes for 36 034 subjects, aged between 35 and 74 years, in 27 centres were obtained using standardized 24-h dietary recall software (EPIC-SOFT). Mean intakes of calcium, phosphorus, magnesium, iron and potassium were calculated by centre and weighted by season and day of the week and were also stratified by age group. The contribution of food groups to total nutrient intake was calculated. Results: There was clear geographical variability in intakes, with differences ranging from 35% for magnesium to 90% for iron in men and 36% for potassium to 75% for calcium in women, and a twofold difference in sources of haem iron (meat and fish). There was a geographical gradient in iron intake, with higher intakes in Southern than in Northern Europe and also around a twofold north-south gradient in the contribution of fruits and vegetables to potassium intake. Compared with reference intakes, the majority of age groups and centres had intakes above the recommended levels. Dairy foods and products contributed the most to calcium and phosphorus intake in almost all centres. Cereals and cereal products contributed the most to magnesium and iron intakes, except in Greece and Germany. Conclusions: Intakes of minerals vary substantially throughout Europe, with some geographical variability in their food sources. doi: 10.1038/ejcn.2009.77 Keywords: calcium; phosphorus; magnesium; iron; potassium; EPIC, Introduction Minerals are essential nutrients, and adequate intakes are important not only for the maintenance of bone health but also for cellular function and general metabolism. Aspects of mineral metabolism [...]
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- 2009
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31. Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort
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Schlesinger, S., Aleksandrova, K., Pischon, T., Jenab, M., Fedirko, V., Trepo, E., Overvad, K., Roswall, N., Tjønneland, A., Boutron-Ruault, M. C., Fagherazzi, G., Racine, A., Kaaks, R., Grote, V. A., Boeing, H., Trichopoulou, A., Pantzalis, M., Kritikou, M., Mattiello, A., Sieri, S., Sacerdote, C., Palli, D., Tumino, R., Peeters, P. H., Bueno-de-Mesquita, H. B., Weiderpass, E., Quirós, J. R., Zamora-Ros, R., Sánchez, M. J., Arriola, L., Ardanaz, E., Tormo, M. J., Nilsson, P., Lindkvist, B., Sund, M., Rolandsson, O., Khaw, K. T., Wareham, N., Travis, R. C., Riboli, E., and Nöthlings, U.
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- 2013
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32. Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Fedirko, V., Trichopolou, A., Bamia, C., Duarte-Salles, T., Trepo, E., Aleksandrova, K., Nöthlings, U., Lukanova, A., Lagiou, P., Boffetta, P., Trichopoulos, D., Katzke, V. A., Overvad, K., Tjønneland, A., Hansen, L., Boutron-Ruault, M. C., Fagherazzi, G., Bastide, N., Panico, S., Grioni, S., Vineis, P., Palli, D., Tumino, R., Bueno-de-Mesquita, H. B., Peeters, P. H., Skeie, G., Engeset, D., Parr, C. L., Jakszyn, P., Sánchez, M. J., Barricarte, A., Amiano, P., Chirlaque, M., Quirós, J. R., Sund, M., Werner, M., Sonestedt, E., Ericson, U., Key, T. J., Khaw, K. T., Ferrari, P., Romieu, I., Riboli, E., and Jenab, M.
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- 2013
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33. Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in Western Europeans
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Fedirko, V., Lukanova, A., Bamia, C., Trichopolou, A., Trepo, E., Nöthlings, U., Schlesinger, S., Aleksandrova, K., Boffetta, P., Tjønneland, A., Johnsen, N. F., Overvad, K., Fagherazzi, G., Racine, A., Boutron-Ruault, M. C., Grote, V., Kaaks, R., Boeing, H., Naska, A., Adarakis, G., Valanou, E., Palli, D., Sieri, S., Tumino, R., Vineis, P., Panico, S., Bueno-de-Mesquita, H. B(as)., Siersema, P. D., Peeters, P. H., Weiderpass, E., Skeie, G., Engeset, D., Quirós, J. R., Zamora-Ros, R., Sánchez, M. J., Amiano, P., Huerta, J. M., Barricarte, A., Johansen, D., Lindkvist, B., Sund, M., Werner, M., Crowe, F., Khaw, K. T., Ferrari, P., Romieu, I., Chuang, S. C., Riboli, E., and Jenab, M.
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- 2013
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34. Die Rolle von Vitaminen und Spurenelementen bei der Entstehung von Krebserkrankungen
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Nöthlings, U., Walter, D., Bergmann, M., Kroke, A., and Boeing, H.
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- 2002
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35. Total dietary carbohydrate, sugar, starch and fibre intakes in the European Prospective Investigation into Cancer and Nutrition
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Cust, A E, Skilton, M R, van Bakel, MME, Halkjær, J, Olsen, A, Agnoli, C, Psaltopoulou, T, Buurma, E, Sonestedt, E, Chirlaque, M D, Rinaldi, S, Tjønneland, A, Jensen, M K, Clavel-Chapelon, F, Boutron-Ruault, M C, Kaaks, R, Nöthlings, U, Chloptsios, Y, Zylis, D, Mattiello, A, Caini, S, Ocké, M C, van der Schouw, Y T, Skeie, G, Parr, C L, Molina-Montes, E, Manjer, J, Johansson, I, McTaggart, A, Key, T J, Bingham, S, Riboli, E, and Slimani, N
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- 2009
36. Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort
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Gasull, M. Pumarega, J. Kiviranta, H. Rantakokko, P. Raaschou-Nielsen, O. Bergdahl, I.A. Sandanger, T.M. Goñi, F. Cirera, L. Donat-Vargas, C. Alguacil, J. Iglesias, M. Tjønneland, A. Overvad, K. Mancini, F.R. Boutron-Ruault, M.-C. Severi, G. Johnson, T. Kühn, T. Trichopoulou, A. Karakatsani, A. Peppa, E. Palli, D. Pala, V. Tumino, R. Naccarati, A. Panico, S. Verschuren, M. Vermeulen, R. Rylander, C. Nøst, T.H. Rodríguez-Barranco, M. Molinuevo, A. Chirlaque, M.-D. Ardanaz, E. Sund, M. Key, T. Ye, W. Jenab, M. Michaud, D. Matullo, G. Canzian, F. Kaaks, R. Nieters, A. Nöthlings, U. Jeurnink, S. Chajes, V. Matejcic, M. Gunter, M. Aune, D. Riboli, E. Agudo, A. Gonzalez, C.A. Weiderpass, E. Bueno-de-Mesquita, B. Duell, E.J. Vineis, P. Porta, M.
- Abstract
Background: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. Objectives: First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort– on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. Methods: Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. Results: There were differences among countries in subjects’ characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p’-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB. Conclusions: The coexistence of differences across study centres in some design features and participant characteristics is of relevance to other multicentre studies. Relationships among subjects’ characteristics and among such characteristics and design features may play important roles in the forthcoming analyses on the association between plasma concentrations of POPs and pancreatic cancer risk. © 2018 Elsevier Inc.
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- 2019
37. Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort
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Gasull, M., Pumarega, J., Kiviranta, H., Rantakokko, P., Raaschou-Nielsen, O., Bergdahl, I.A., Sandanger, T.M., Goñi, F., Cirera, L., Donat-Vargas, C., Alguacil, J., Iglesias, M., Tjønneland, A., Overvad, K., Mancini, F.R., Boutron-Ruault, M.-C., Severi, G., Johnson, T., Kühn, T., Trichopoulou, A., Karakatsani, A., Peppa, E., Palli, D., Pala, V., Tumino, R., Naccarati, A., Panico, S., Verschuren, M., Vermeulen, R., Rylander, C., Nøst, T.H., Rodríguez-Barranco, M., Molinuevo, A., Chirlaque, M.-D., Ardanaz, E., Sund, M., Key, T., Ye, W., Jenab, M., Michaud, D., Matullo, G., Canzian, F., Kaaks, R., Nieters, A., Nöthlings, U., Jeurnink, S., Chajes, V., Matejcic, M., Gunter, M., Aune, D., Riboli, E., Agudo, A., Weiderpass, E., Bueno-de-Mesquita, B., Duell, E.J., Vineis, P., Porta, M., Gasull, M., Pumarega, J., Kiviranta, H., Rantakokko, P., Raaschou-Nielsen, O., Bergdahl, I.A., Sandanger, T.M., Goñi, F., Cirera, L., Donat-Vargas, C., Alguacil, J., Iglesias, M., Tjønneland, A., Overvad, K., Mancini, F.R., Boutron-Ruault, M.-C., Severi, G., Johnson, T., Kühn, T., Trichopoulou, A., Karakatsani, A., Peppa, E., Palli, D., Pala, V., Tumino, R., Naccarati, A., Panico, S., Verschuren, M., Vermeulen, R., Rylander, C., Nøst, T.H., Rodríguez-Barranco, M., Molinuevo, A., Chirlaque, M.-D., Ardanaz, E., Sund, M., Key, T., Ye, W., Jenab, M., Michaud, D., Matullo, G., Canzian, F., Kaaks, R., Nieters, A., Nöthlings, U., Jeurnink, S., Chajes, V., Matejcic, M., Gunter, M., Aune, D., Riboli, E., Agudo, A., Weiderpass, E., Bueno-de-Mesquita, B., Duell, E.J., Vineis, P., and Porta, M.
- Abstract
Background The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. Objectives First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort– on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. Methods Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. Results There were differences among countries in subjects’ characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, cou
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- 2019
38. Joint Data Analysis in Nutritional Epidemiology: Identification of Observational Studies and Minimal Requirements.
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Universitat Rovira i Virgili, Pinart M, Nimptsch K, Bouwman J, Dragsted LO, Yang C, De Cock N, Lachat C, Perozzi G, Canali R, Lombardo R, D'Archivio M, Guillaume M, Donneau AF, Jeran S, Linseisen J, Kleiser C, Nöthlings U, Barbaresko J, Boeing H, Stelmach-Mardas M, Heuer T, Laird E, Walton J, Gasparini P, Robino A, Castaño L, Rojo-Martínez G, Merino J, Masana L, Standl M, Schulz H, Biagi E, Nurk E, Matthys C, Gobbetti M, de Angelis M, Windler E, Zyriax BC, Tafforeau J, Pischon T, Universitat Rovira i Virgili, and Pinart M, Nimptsch K, Bouwman J, Dragsted LO, Yang C, De Cock N, Lachat C, Perozzi G, Canali R, Lombardo R, D'Archivio M, Guillaume M, Donneau AF, Jeran S, Linseisen J, Kleiser C, Nöthlings U, Barbaresko J, Boeing H, Stelmach-Mardas M, Heuer T, Laird E, Walton J, Gasparini P, Robino A, Castaño L, Rojo-Martínez G, Merino J, Masana L, Standl M, Schulz H, Biagi E, Nurk E, Matthys C, Gobbetti M, de Angelis M, Windler E, Zyriax BC, Tafforeau J, Pischon T
- Abstract
Background: Joint data analysis from multiple nutrition studies may improve the ability to answer complex questions regarding the role of nutritional status and diet in health and disease. Objective: The objective was to identify nutritional observational studies from partners participating in the European Nutritional Phenotype Assessment and Data Sharing Initiative (ENPADASI) Consortium, as well as minimal requirements for joint data analysis. Methods: A predefined template containing information on study design, exposure measurements (dietary intake, alcohol and tobacco consumption, physical activity, sedentary behavior, anthropometric measures, and sociodemographic and health status), main health-related outcomes, and laboratory measurements (traditional and omics biomarkers) was developed and circulated to those European research groups participating in the ENPADASI under the strategic research area of 'diet-related chronic diseases.' Information about raw data disposition and metadata sharing was requested. A set of minimal requirements was abstracted from the gathered information. Results: Studies (12 cohort, 12 cross-sectional, and 2 case-control) were identified. Two studies recruited children only and the rest recruited adults. All studies included dietary intake data. Twenty studies collected blood samples. Data on traditional biomarkers were available for 20 studies, of which 17 measured lipoproteins, glucose, and insulin and 13 measured inflammatory biomarkers. Metabolomics, proteomics, and genomics or transcriptomics data were available in 5, 3, and 12 studies, respectively. Although the study authors were willing to share metadata, most refused, were hesitant, or had legal or ethical issues related to sharing raw data. Forty-one descriptors of minimal requ
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- 2018
39. New genetic loci link adipose and insulin biology to body fat distribution
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Shungin, D, Winkler, T, Croteau Chonka, D, Ferreira, T, Locke, A, Mägi, R, Strawbridge, R, Pers, T, Fischer, K, Justice, A, Workalemahu, T, Wu, J, Buchkovich, M, Heard Costa, N, Roman, T, Drong, A, Song, C, Gustafsson, S, Day, F, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J, Scherag, A, Vedantam, S, Wood, A, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg Gresham, J, Buyske, S, Demirkan, A, Ehret, G, Feitosa, M, Goel, A, Jackson, A, Johnson, T, Kleber, M, Kristiansson, K, Mangino, M, Leach, I, Medina Gomez, C, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Stanca'Kova', A, Sung, Y, Tanaka, T, Teumer, A, Van Vliet Ostaptchouk, J, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, G, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, D, Caspersen, I, Clarke, R, Daw, E, Deelen, J, Deelman, E, Delgado, G, Doney, A, Eklund, N, Erdos, M, Estrada, K, Eury, E, Friedrich, N, Garcia, M, Giedraitis, V, Gigante, B, Go, A, Golay, A, Grallert, H, Grammer, T, Gräsler, J, Grewal, J, Groves, C, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heikkilä, K, Herzig, K, Helmer, Q, Hillege, H, Holmen, O, Hunt, S, Isaacs, A, Ittermann, T, James, A, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I, Kratzer, W, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K, Mooijaart, S, Mühleisen, T, Mulas, A, Müller, G, Müller Nurasyid, M, Nagaraja, R, Nalls, M, Narisu, N, Glorioso, N, Nolte, I, Olden, M, Rayner, N, Renstrom, F, Ried, J, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C, Smith, A, Stirrups, K, Stringham, H, Sundström, J, Swertz, M, Swift, A, Syvänen, A, Tayo, B, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, Van Oort, F, Verweij, N, Vonk, J, Waite, L, Wennauer, R, Wilsgaard, T, Wojczynski, M, Wong, A, Zhang, Q, Zhao, J, Brennan, E, Choi, M, Eriksson, P, Folkersen, L, Franco Cereceda, A, Gharavi, A, Hedman, A, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R, Ma, B, Mcknight, A, Mcpherson, R, Metspalu, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Olsson, C, Perry, J, Reinmaa, E, Salem, R, Sandholm, N, Schadt, E, Scott, R, Stolk, L, Vallejo, E, Westra, H, Zondervan, K, Amouyel, P, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Brown, M, Burnier, M, Campbell, H, Chakravarti, A, Chines, P, Claudi Boehm, S, Collins, F, Crawford, D, Danesh, J, De Faire, U, De Geus, E, Dörr, M, Erbel, R, Eriksson, J, Farrall, M, Ferrannini, E, Ferrières, J, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gieger, C, Gudnason, V, Haiman, C, Harris, T, Hattersley, A, 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- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
40. Genetic studies of body mass index yield new insights for obesity biology
- Author
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- Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
- Published
- 2015
41. Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study
- Author
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Zamora-Ros, R, Fedirko, V, Trichopoulou, A, González, C, Bamia, C, Trepo, E, Nöthlings, U, Duarte-Salles, T, Serafini, M, Bredsdorff, L, Overvad, K, Tjønneland, A, Halkjaer, J, Fagherazzi, G, Perquier, F, Boutron-Ruault, M, Katzke, V, Lukanova, A, Floegel, A, Boeing, H, Lagiou, P, Trichopoulos, D, Saieva, C, Agnoli, C, and Mattiello, A
- Abstract
Limited epidemiological evidence suggests a protective role for plant foods rich in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim was to prospectively investigate the association between dietary intake of flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk. Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 477,206 subjects (29.8% male) recruited from ten Western European countries, was analyzed. Flavonoid, lignan and NEAC intakes were calculated using a compilation of existing food composition databases linked to dietary information from validated dietary questionnaires. Dietary NEAC was based on ferric reducing antioxidant capacity (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hepatitis B/C status was measured in a nested case-control subset. During a mean follow-up of 11-years, 191 incident HCC cases (66.5% men) were identified. Using Cox regression, multivariable adjusted models showed a borderline nonsignificant association of HCC with total flavonoid intake (highest versus lowest tertile, HR=0.65, 95% CI: 0.40-1.04; p=0.065), but not with lignans. Among flavonoid subclasses, flavanols were inversely associated with HCC risk (HR=0.62, 95% CI: 0.39-0.99; p=0.06). Dietary NEAC was inversely associated with HCC (FRAP: HR 0.50, 95% CI: 0.31-0.81; p=0.001; TRAP: HR 0.49, 95% CI: 0.31-0.79; p=0.002), but statistical significance was lost after exclusion of the first 2 years of follow-up. This study suggests that higher intake of dietary flavanols and antioxidants may be associated with a reduced HCC risk. What's new? Coffee, tea, fruits and vegetables, and certain other foods may protect against hepatocellular carcinoma (HCC), thanks to their antioxidant ingredients. This study lends fresh support to that idea, revealing specifically that dietary flavanols, which possess antioxidant activity, could play a favourable role in HCC prevention. Dietary antioxidant capacity from coffee intake in particular was found to be inversely associated with HCC risk, though statistical significance was lost after exclusion of the first two years of follow-up. Assessment of the bioavailability of flavonoids and other antioxidants is needed to confirm links between antioxidant intake and HCC risk. Department, Catalan Institute of Oncology, IDIBELL, Hospital Duran i Reynals, Gran Via 199-203, E-08908 L'Hospitalet de Llobregat, Barcelona, Spain. © 2013 UICC.
- Published
- 2016
42. Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: etiological factors or risk markers?
- Author
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Lukanova, A, Becker, S, Hüsing, A, Schock, H, Fedirko, V, Trepo, E, Trichopoulou, A, Bamia, C, Lagiou, P, Benetou, V, Trichopoulos, D, Nöthlings, U, Tjønneland, A, Overvad, K, Dossus, L, Teucher, B, Boeing, H, Aleksandrova, K, Palli, D, Pala, V, Panico, S, Tumino, R, Ricceri, F, Bueno-de-Mesquita, H, and Siersema, P
- Abstract
Elevated prediagnostic testosterone and insulin-like growth factor I (IGF-I) concentrations have been proposed to increase risk of hepatocellular carcinoma (HCC). However, the metabolism of these hormones is altered as a consequence of liver damage and they may have clinical utility as HCC risk markers. A case-control study was nested within the European Prospective Investigation into Cancer and Nutrition cohort and included 125 incident HCC cases and 247 individually matched controls. Testosterone, sex hormone-binding globulin (SHBG) and IGF-I were analyzed by immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by conditional logistic regression. The area under the receiver operating curves (AUC) was calculated to assess HCC predictive ability of the tested models. After adjustments for epidemiological variables (body mass index, smoking, ethanol intake, hepatitis and diabetes) and liver damage (a score based on albumin, bilirubin, aspartate aminotransaminase, alanine aminotransaminase, gamma-glutamyltransferase and alkaline phosphatase concentrations), only SHBG remained significantly associated with risk [OR for top versus bottom tertile of 3.86 (1.32-11.3), p(trend) = 0.009]. As a single factor SHBG had an AUC of 0.81 (0.75-0.86). A small, but significant increase in AUC was observed when SHBG was added to a model including the liver damage score and epidemiological variables (from 0.89 to 0.91, p = 0.02) and a net reclassification of 0.47% (0.45-0.48). The observed associations of HCC with prediagnostic SHBG, free testosterone and IGF-I concentrations are in directions opposite to that expected under the etiological hypotheses. SHBG has a potential to be tested as prediagnostic risk marker for HCC.
- Published
- 2016
43. Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population
- Author
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Nöthlings, U, Schulze, M, Weikert, C, Boeing, H, van der Schouw, Y, Bamia, C, Benetou, V, Lagiou, P, Krogh, V, Beulens, J, Peeters, P, Halkjaer, J, Tjønneland, A, Tumino, R, Panico, S, Masala, G, Clavel-Chapelon, F, de Lauzon, B, Boutron-Ruault, M, Vercambre, M, Kaaks, R, Linseisen, J, Overvad, K, Arriola, L, and Ardanaz, E
- Abstract
We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific mortality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Prospective Investigation into Cancer and Nutrition study was followed for a mean of 9 y. Intakes of vegetables, legumes, and fruit were assessed at baseline between 1992 and 2000 using validated country-specific questionnaires. A total of 1346 deaths occurred. Multivariate relative risks (RR) for all-cause mortality were estimated in Cox regression models and RR for cause-specific mortality were derived in a competing risk model. An increment in intake of total vegetables, legumes, and fruit of 80 g/d was associated with a RR of death from all causes of 0.94 [95% CI 0.90-0.98]. Analyzed separately, vegetables and legumes were associated with a significantly reduced risk, whereas nonsignificant inverse associations for fruit intake were observed. Cardiovascular disease (CVD) mortality and mortality due to non-CVD/non-cancer causes were significantly inversely associated with intake of total vegetables, legumes, and fruit (RR 0.88 [95% CI 0.81-0.95] and 0.90 [0.82-0.99], respectively) but not cancer mortality (1.08 [0.99-1.17]). Intake of vegetables, legumes, and fruit was associated with reduced risks of all-cause and CVD mortality in a diabetic population. The findings support the current state of evidence from general population studies that the protective potential of vegetable and fruit intake is larger for CVD than for cancer and suggest that diabetes patients may benefit from a diet high in vegetables and fruits.
- Published
- 2016
44. Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer
- Author
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Aleksandrova, K, Boeing, H, Nöthlings, U, Jenab, M, Fedirko, V, Kaaks, R, Lukanova, A, Trichopoulou, A, Trichopoulos, D, Boffetta, P, Trepo, E, Westhpal, S, Duarte-Salles, T, Stepien, M, Overvad, K, Tjønneland, A, Halkjaer, J, Boutron-Ruault, M, Dossus, L, Racine, A, Lagiou, P, Bamia, C, Benetou, V, Agnoli, C, and Palli, D
- Abstract
Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however, there are little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intrahepatic bile duct (IBD), and gallbladder and biliary tract cancers outside of the liver (GBTC) in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Over an average of 7.7 years, 296 participants developed HCC (n=125), GBTC (n=137), or IBD (n=34). Using risk-set sampling, controls were selected in a 2:1 ratio and matched for recruitment center, age, sex, fasting status, and time of blood collection. Baseline serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, total high-molecular-weight (HMW) adiponectin, leptin, fetuin-a, and glutamatdehydrogenase (GLDH) were measured, and incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for lifestyle factors, diabetes, hepatitis infection, and adiposity measures, higher concentrations of CRP, IL-6, C-peptide, and non-HMW adiponectin were associated with higher risk of HCC (IRR per doubling of concentrations=1.22; 95% CI=1.02-1.46; P = 0.03; 1.90; 95% CI=1.30-2.77; P = 0.001; 2.25; 95% CI=1.43-3.54; P = 0.0005; and 2.09; 95% CI=1.19-3.67; P = 0.01, respectively). CRP was associated also with risk of GBTC (IRR=1.22; 95% CI=1.05-1.42; P = 0.01). GLDH was associated with risks of HCC (IRR=1.62; 95% CI=1.25-2.11; P = 0.0003) and IBD (IRR=10.5; 95% CI=2.20-50.90; P = 0.003). The continuous net reclassification index was 0.63 for CRP, IL-6, C-peptide, and non-HMW adiponectin and 0.46 for GLDH, indicating good predictive ability of these biomarkers. Conclusion: Elevated levels of biomarkers of inflammation and hyperinsulinemia are associated with a higher risk of HCC, independent of obesity and established liver cancer risk factors. © 2014 The Authors. Hepatology published by Wiley on behalf of the American Association for the Study of Liver Diseases.
- Published
- 2016
45. Inflammatory and Metabolic Biomarkers and Risk of Liver and Biliary Tract Cancer
- Author
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Aleksandrova K, Boeing H, Nöthlings U, Jenab M, Fedirko V, Kaaks R, Lukanova A, Trichopoulou A, Trichopoulos D, Boffetta P, Trepo E, Westhpal S, Talita Duarte-Salles, Stepien M, Overvad K, Tjønneland A, Halkjaer J, Mc, Boutron-Ruault, Dossus L, Racine A, Lagiou P, Bamia C, Benetou V, Agnoli C, Palli D, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita B, Ph, Peeters, It, Gram, Lund E, Weiderpass E, Jr, Quirós, Agudo A, Mj, Sánchez, Gavrila D, Barricarte A, Dorronsoro M, Ohlsson B, Lindkvist B, Johansson A, Sund M, Kt, Khaw, Wareham N, Rc, Travis, Riboli E, Pischon T, Aleksandrova, K, Boeing, H, N?thlings, U, Jenab, M, Fedirko, V, Kaaks, R, Lukanova, A, Trichopoulou, A, Trichopoulos, D, Boffetta, P, Trepo, E, Westhpal, S, Duarte Salles, T, Stepien, M, Overvad, K, Tj?nneland, A, Halkjaer, J, Boutron Ruault, Mc, Dossus, L, Racine, A, Lagiou, P, Bamia, C, Benetou, V, Agnoli, C, Palli, D, Panico, Salvatore, Tumino, R, Vineis, P, Bueno de Mesquita, B, Peeters, Ph, Gram, It, Lund, E, Weiderpass, E, Quir?s, Jr, Agudo, A, S?nchez, Mj, Gavrila, D, Barricarte, A, Dorronsoro, M, Ohlsson, B, Lindkvist, B, Johansson, A, Sund, M, Khaw, Kt, Wareham, N, Travis, Rc, Riboli, E, Pischon, T., Aleksandrova, K., Boeing, H., Nöthlings, U., Jenab, M., Fedirko, V., Kaaks, R., Lukanova, A., Trichopoulou, A., Trichopoulos, D., Boffetta, P., Trepo, E., Westhpal, S., Duarte-Salles, T., Stepien, M., Overvad, K., Tjønneland, A., Halkjær, J., Boutron-Ruault, M.-C., Dossus, L., Racine, A., Lagiou, P., Bamia, C., Benetou, V., Agnoli, C., Palli, D., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, B., Peeters, P.H., Gram, I.T., Lund, E., Weiderpass, E., Quirós, J.R., Agudo, A., Sánchez, M.-J., Gavrila, D., Barricarte, A., Dorronsoro, M., Ohlsson, B., Lindkvist, B., Johansson, A., Sund, M., Khaw, K.-T., Wareham, N., Travis, R.C., and Riboli, E.
- Subjects
metabolic disorder ,Adult ,Male ,Carcinoma, Hepatocellular ,INTERLEUKIN-6 ,Gastroenterology and Hepatology ,DISEASE ,COLORECTAL-CANCER ,LEPTIN ,ADIPONECTIN ,Risk Factors ,INJURY ,EPIDEMIOLOGY ,Humans ,Prospective Studies ,Aged ,Inflammation ,INSULIN-RESISTANCE ,Science & Technology ,Gastroenterology & Hepatology ,Incidence ,Liver Neoplasms ,1103 Clinical Sciences ,Middle Aged ,Biliary Tract Neoplasms ,liver carcinogenesis ,HEPATOCELLULAR-CARCINOMA RISK ,1101 Medical Biochemistry and Metabolomics ,Cardiovascular and Metabolic Diseases ,1107 Immunology ,OBESITY ,Case-Control Studies ,Female ,Life Sciences & Biomedicine ,Biomarkers - Abstract
Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however, there are little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intrahepatic bile duct (IBD), and gallbladder and biliary tract cancers outside of the liver (GBTC) in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. Over an average of 7.7 years, 296 participants developed HCC (n=125), GBTC (n=137), or IBD (n=34). Using risk-set sampling, controls were selected in a 2:1 ratio and matched for recruitment center, age, sex, fasting status, and time of blood collection. Baseline serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, total high-molecular-weight (HMW) adiponectin, leptin, fetuin-a, and glutamatdehydrogenase (GLDH) were measured, and incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for lifestyle factors, diabetes, hepatitis infection, and adiposity measures, higher concentrations of CRP, IL-6, C-peptide, and non-HMW adiponectin were associated with higher risk of HCC (IRR per doubling of concentrations=1.22; 95% CI=1.02-1.46; P = 0.03; 1.90; 95% CI=1.30-2.77; P = 0.001; 2.25; 95% CI=1.43-3.54; P = 0.0005; and 2.09; 95% CI=1.19-3.67; P = 0.01, respectively). CRP was associated also with risk of GBTC (IRR=1.22; 95% CI=1.05-1.42; P = 0.01). GLDH was associated with risks of HCC (IRR=1.62; 95% CI=1.25-2.11; P = 0.0003) and IBD (IRR=10.5; 95% CI=2.20-50.90; P = 0.003). The continuous net reclassification index was 0.63 for CRP, IL-6, C-peptide, and non-HMW adiponectin and 0.46 for GLDH, indicating good predictive ability of these biomarkers. Conclusion: Elevated levels of biomarkers of inflammation and hyperinsulinemia are associated with a higher risk of HCC, independent of obesity and established liver cancer risk factors. © 2014 The Authors. Hepatology published by Wiley on behalf of the American Association for the Study of Liver Diseases.
- Published
- 2014
46. PopGen
- Author
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Nöthlings U and Krawczak M
- Subjects
education.field_of_study ,medicine.medical_specialty ,business.industry ,Population ,Public Health, Environmental and Occupational Health ,Population based ,Biobank ,Internal medicine ,Cohort ,medicine ,Biomarker (medicine) ,Genetic risk ,education ,business ,Prospective cohort study ,Body fat distribution - Abstract
The PopGen biobank was established in 2003 for research into the genetic risk factors for complex diseases. In addition to specific patient groups, a random sample from the general population was recruited as well. This cross-sectional study was mainly used as a control sample in genetic-epidemiological research. Recently, this part of the biobank was developed further into a prospective cohort study to investigate longitudinal changes of inflammatory biomarkers. Between 2005 and 2007, 1,317 study participants (age: 19-77 years, 55% men) were recruited into the PopGen control cohort, 747 via the local population registry and 570 as blood donors. Baseline assessment comprised a questionnaire, a medical examination, sampling of blood as well as ad hoc analyses of a range of biomarkers and genetic factors. Beginning in 2010, all study participants were re-invited for a program that was expanded by a food frequency questionnaire, collection of urine and stool samples, and an offer of magnetic resonance imaging to capture body fat distribution. The current response proportion is approximately 70%. The development of the PopGen controls into a prospective cohort study was originally driven by biomarker research questions, for instance related to chronic inflammation. Future follow-up will now also enable research into the influence of lifestyle variables.
- Published
- 2012
47. Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
- Author
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Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, CC, Overvad, K, Tjønneland, A, Halkjær, J, Fagherazzi, G, Boutron-Ruault, MC, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, S, Tumino, R, Vineis, P, Hb, BDM, Van Den Berg, S, Peeters, PHM, Braaten, T, Weiderpass, E, Quirós, JR, Travier, N, Sánchez, MJ, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, KT, Wareham, N, Travis, RC, Norat, T, Wark, PA, Riboli, E, Nöthlings, U, Schlesinger, S, Aleksandrova, K, Pischon, T, Fedirko, V, Jenab, M, Trepo, E, Boffetta, P, Dahm, Cc, Overvad, K, Tj?nneland, A, Halkj?r, J, Fagherazzi, G, Boutron Ruault, Mc, Carbonnel, F, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Bamia, C, Lagiou, P, Palli, D, Grioni, S, Panico, Salvatore, Tumino, R, Vineis, P, Bueno de Mesquita, Hb, van den Berg, S, Peeters, Ph, Braaten, T, Weiderpass, E, Quir?s, Jr, Travier, N, S?nchez, Mj, Navarro, C, Barricarte, A, Dorronsoro, M, Lindkvist, B, Regner, S, Werner, M, Sund, M, Khaw, Kt, Wareham, N, Travis, Rc, Norat, T, Wark, Pa, Riboli, E, N?thlings, U., Schlesinger, S., Aleksandrova, K., Pischon, T., Fedirko, V., Jenab, M., Trepo, E., Boffetta, P., Dahm, C.C., Overvad, K., Tjønneland, A., Halkjær, J., Fagherazzi, G., Boutron-Ruault, M.-C., Carbonnel, F., Kaaks, R., Lukanova, A., Boeing, H., Trichopoulou, A., Bamia, C., Lagiou, P., Palli, D., Grioni, S., Panico, S., Tumino, R., Vineis, P., Hb, B.-D.-M., Van Den Berg, S., Peeters, P.H.M., Braaten, T., Weiderpass, E., Quirós, J.R., Travier, N., Sánchez, M.-J., Navarro, C., Barricarte, A., Dorronsoro, M., Lindkvist, B., Regner, S., Werner, M., Sund, M., Khaw, K.-T., Wareham, N., Travis, R.C., Norat, T., Wark, P.A., Riboli, E., Nöthlings, U., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, and Icahn School of Medicine at Mount Sinai [New York] (MSSM)
- Subjects
Male ,Cancer Research ,obesity ,Weight Gain ,Gastroenterology ,Body Mass Index ,Hepatocellular/*epidemiology/etiology Case-Control Studies Europe/epidemiology Female Hepatitis B/epidemiology Hepatitis C/epidemiology Humans Liver Neoplasms/*epidemiology/etiology Male Middle Aged Nutritional Status Obesity ,Biliary Tract Neoplasms/*epidemiology/etiology Body Composition Body Mass Index Body Weight Carcinoma ,hepatocellular carcinoma (HCC) ,0302 clinical medicine ,Waist–hip ratio ,intrahepatic (IBDC) ,Prospective Studies ,Prospective cohort study ,Abdominal/*epidemiology Proportional Hazards Models Prospective Studies Waist-Hip Ratio *Weight Gain ,Abdominal obesity ,extrahepatic bile duct system cancer ,2. Zero hunger ,Liver Neoplasms ,weight gain ,Middle Aged ,Hepatitis B ,Hepatitis C ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Europe ,Biliary Tract Neoplasms ,Oncology ,030220 oncology & carcinogenesis ,Obesity, Abdominal ,Body Composition ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,adulthood ,liver and biliary tract cancer ,Nutritional Status ,abdominal obesity ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Gallbladder cancer ,Proportional Hazards Models ,business.industry ,Waist-Hip Ratio ,Weight change ,Body Weight ,medicine.disease ,Endocrinology ,Relative risk ,Case-Control Studies ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Body mass index - Abstract
Schlesinger, Sabrina Aleksandrova, Krasimira Pischon, Tobias Fedirko, Veronika Jenab, Mazda Trepo, Elisabeth Boffetta, Paolo Dahm, Christina C Overvad, Kim Tjonneland, Anne Halkjaer, Jytte Fagherazzi, Guy Boutron-Ruault, Marie-Christine Carbonnel, Franck Kaaks, Rudolf Lukanova, Annekatrin Boeing, Heiner Trichopoulou, Antonia Bamia, Christina Lagiou, Pagona Palli, Domenico Grioni, Sara Panico, Salvatore Tumino, Rosario Vineis, Paolo Bueno-de-Mesquita, H B van den Berg, Saskia Peeters, Petra H M Braaten, Tonje Weiderpass, Elisabete Quiros, J Ramon Travier, Noemie Sanchez, Maria-Jose Navarro, Carmen Barricarte, Aurelio Dorronsoro, Miren Lindkvist, Bjorn Regner, Sara Werner, Marten Sund, Malin Khaw, Kay-Tee Wareham, Nicholas Travis, Ruth C Norat, Teresa Wark, Petra A Riboli, Elio Nothlings, Ute eng 11692/Cancer Research UK/United Kingdom G0401527/Medical Research Council/United Kingdom G1000143/Medical Research Council/United Kingdom MC_U106179471/Medical Research Council/United Kingdom British Heart Foundation/United Kingdom Cancer Research UK/United Kingdom Department of Health/United Kingdom Medical Research Council/United Kingdom Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't 2012/05/24 06:00 Int J Cancer. 2013 Feb 1;132(3):645-57. doi: 10.1002/ijc.27645. Epub 2012 Jun 13.; International audience; General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; p(trend) < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13
- Published
- 2013
48. A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site
- Author
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Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd Jones H, Sambrook JG, Tijssen MR, Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Sorice R, Teumer A, Zhang W, Ramirez Solis R, Bis JC, Ellinghaus D, Gögele M, Hottenga JJ, Langenberg C, Kovacs P, F. P, Shin SY, Esko T, Hartiala J, Kanoni S, Murgia F, Parsa A, Stephens J, van der Harst P, van der Schoot C, Allayee H, Attwood A, Balkau B, Bastardot F, Basu S, Baumeister SE, Biino G, Bomba L, Bonnefond A, Cambien F, Chambers JC, Cucca F, Davies G, de Geus EJ, de Boer RA, Döring A, Elliott P, Erdmann J, Feng W, Evans DM, Falchi M, Folsom AR, Frazer IH, Gibson QD, Glazer NL, Hammond C, Hartikainen AL, Heckbert SR, Hengstenberg C, Hersch M, Illig T, Loos RJ, Jolley J, Khaw KT, Kühnel B, Kyrtsonis MC, Lagou V, Lumley T, Mangino M, Maschio A, Mateo Leach I, McKnight B, Memari Y, Mitchell BD, Montgomery GW, Nöthlings U, Nakamura Y, Nauck M, Navis G, Nolte IM, Porteous DJ, Pouta A, Pramstaller PP, Pullat J, Ring SM, Rotter JI, Ruggiero D, Ruokonen A, Sala C, Samani NJ, Sambrook J, Schlessinger D, Schreiber S, Schunkert H, Scott J, Smith NL, Snieder H, Starr JM, Stumvoll M, Takahashi A, Taylor K, Tenesa A, Thein SL, Tönjes A, Uda M, Ulivi S, Wichmann HE, Yang TP, van Veldhuisen DJ, Visscher PM, Völker U, Wiggins KL, Willemsen G, Zhao JH, Zitting P, Bradley JR, Dedoussis GV, Hazen SL, Metspalu A, Pirastu M, Shuldiner AR, van Pelt L, Zwaginga JJ, Boomsma DI, Deary IJ, Franke A, Froguel P, Ganesh SK, Jarvelin MR, Martin NG, Meisinger C, Psaty BM, Spector TD, Wareham NJ, Akkerman JW, Ciullo M, Deloukas P, Greinacher A, Jupe S, Kamatani N, Khadake J, Kooner JS, Penninger J, Prokopenko I, Stemple D, Toniolo D, Wernisch L, Sanna S, Hicks AA, Ferreira MA, Italiano JE Jr, Gottgens B, Soranzo N, Ouwehand WH, PIRASTU, Nicola, D'ADAMO, ADAMO PIO, GASPARINI, PAOLO, Nürnberg, St, Rendon, A, Smethurst, Pa, Paul, D, Voss, K, Thon, Jn, Lloyd Jones, H, Sambrook, Jg, Tijssen, Mr, Gieger, C, Radhakrishnan, A, Cvejic, A, Tang, W, Porcu, E, Pistis, G, Serbanovic Canic, J, Elling, U, Goodall, Ah, Labrune, Y, Lopez, Lm, Mägi, R, Meacham, S, Okada, Y, Pirastu, Nicola, Sorice, R, Teumer, A, Zhang, W, Ramirez Solis, R, Bis, Jc, Ellinghaus, D, Gögele, M, Hottenga, Jj, Langenberg, C, Kovacs, P, F., P, Shin, Sy, Esko, T, Hartiala, J, Kanoni, S, Murgia, F, Parsa, A, Stephens, J, van der Harst, P, van der Schoot, C, Allayee, H, Attwood, A, Balkau, B, Bastardot, F, Basu, S, Baumeister, Se, Biino, G, Bomba, L, Bonnefond, A, Cambien, F, Chambers, Jc, Cucca, F, D'Adamo, ADAMO PIO, Davies, G, de Geus, Ej, de Boer, Ra, Döring, A, Elliott, P, Erdmann, J, Feng, W, Evans, Dm, Falchi, M, Folsom, Ar, Frazer, Ih, Gibson, Qd, Glazer, Nl, Hammond, C, Hartikainen, Al, Heckbert, Sr, Hengstenberg, C, Hersch, M, Illig, T, Loos, Rj, Jolley, J, Khaw, Kt, Kühnel, B, Kyrtsonis, Mc, Lagou, V, Lumley, T, Mangino, M, Maschio, A, Mateo Leach, I, Mcknight, B, Memari, Y, Mitchell, Bd, Montgomery, Gw, Nöthlings, U, Nakamura, Y, Nauck, M, Navis, G, Nolte, Im, Porteous, Dj, Pouta, A, Pramstaller, Pp, Pullat, J, Ring, Sm, Rotter, Ji, Ruggiero, D, Ruokonen, A, Sala, C, Samani, Nj, Sambrook, J, Schlessinger, D, Schreiber, S, Schunkert, H, Scott, J, Smith, Nl, Snieder, H, Starr, Jm, Stumvoll, M, Takahashi, A, Taylor, K, Tenesa, A, Thein, Sl, Tönjes, A, Uda, M, Ulivi, S, Wichmann, He, Yang, Tp, van Veldhuisen, Dj, Visscher, Pm, Völker, U, Wiggins, Kl, Willemsen, G, Zhao, Jh, Zitting, P, Bradley, Jr, Dedoussis, Gv, Gasparini, Paolo, Hazen, Sl, Metspalu, A, Pirastu, M, Shuldiner, Ar, van Pelt, L, Zwaginga, Jj, Boomsma, Di, Deary, Ij, Franke, A, Froguel, P, Ganesh, Sk, Jarvelin, Mr, Martin, Ng, Meisinger, C, Psaty, Bm, Spector, Td, Wareham, Nj, Akkerman, Jw, Ciullo, M, Deloukas, P, Greinacher, A, Jupe, S, Kamatani, N, Khadake, J, Kooner, J, Penninger, J, Prokopenko, I, Stemple, D, Toniolo, D, Wernisch, L, Sanna, S, Hicks, Aa, Ferreira, Ma, Italiano JE, Jr, Gottgens, B, Soranzo, N, Ouwehand, Wh, Biological Psychology, and EMGO+ - Mental Health
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Netherlands Twin Register (NTR) ,Transcription, Genetic ,Gene Expression ,Biochemistry ,megakaryocyte ,Mice ,DNM3 promoter ,Transcription (biology) ,GWAS ,Platelet ,Thrombopoiesis ,Myeloid Ecotropic Viral Integration Site 1 Protein ,Promoter Regions, Genetic ,Cells, Cultured ,Reverse Transcriptase Polymerase Chain Reaction ,Hematology ,Neoplasm Proteins ,Haematopoiesis ,Transcription Initiation Site ,Megakaryocytes ,platelet volume ,DNM3 ,megakaryocytes ,MEIS1 ,Blood Platelets ,Chromatin Immunoprecipitation ,Immunology ,Biology ,Polymorphism, Single Nucleotide ,MEIS1 binding site ,SDG 3 - Good Health and Well-being ,Cell Line, Tumor ,Animals ,Humans ,Cell Lineage ,Binding site ,Gene ,Transcription factor ,Homeodomain Proteins ,Binding Sites ,Genome, Human ,Platelet Count ,Hydrazones ,Genetic Variation ,Cell Biology ,Sequence Analysis, DNA ,Platelets and Thrombopoiesis ,Molecular biology ,Dynamin III - Abstract
We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from hematopoietic stem cells by a process mainly controlled by transcription factors. The homeobox transcription factor MEIS1 is uniquely transcribed in megakaryocytes and not in the other lineage-committed blood cells. By ChIP-seq, we show that 5 of the 68 loci pinpoint a MEIS1 binding event within a group of 252 MK-overexpressed genes. In one such locus in DNM3, regulating platelet volume, the MEIS1 binding site falls within a region acting as an alternative promoter that is solely used in megakaryocytes, where allelic variation dictates different levels of a shorter transcript. The importance of dynamin activity to the latter stages of thrombopoiesis was confirmed by the observation that the inhibitor Dynasore reduced murine proplatelet for-mation in vitro.
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- 2013
49. Glycemic index, glycemic load, dietary carbohydrate, and dietary fiber intake and risk of liver and biliary tract cancers in s
- Author
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Fedirko, V., Lukanova, A., Bamia, C., Trichopolou, A., Trepo, E., Nöthlings, U., Schlesinger, S., Aleksandrova, K., Boffetta, P., Tjønneland, A., Johnsen, N. F., Overvad, K., Fagherazzi, G., Racine, A., Boutron-Ruault, M. C., Grote, V., Kaaks, R., Boeing, H., Naska, A., Adarakis, G., Valanou, E., Palli, D., Sieri, S., Tumino, R., Vineis, P., Panico, S., Bueno-de-mesquita, H. B., Siersema, P. D., Peeters, P. H., Weiderpass, E., Skeie, G., Engeset, D., Quirós, J. R., Zamora-Ros, R., Sánchez, M. J., Amiano, P., Huerta, J. M., Barricarte, A., Johansen, D., Lindkvist, B., Sund, M., Werner, M., Crowe, F., Khaw, K. T., Ferrari, P., Romieu, I., Chuang, S. C., Riboli, E., Jenab, M., Fedirko, V., Lukanova, A., Bamia, C., Trichopolou, A., Trepo, E., Nöthlings, U., Schlesinger, S., Aleksandrova, K., Boffetta, P., Tjønneland, A., Johnsen, N.F., Overvad, K., Fagherazzi, G., Racine, A., Boutron-Ruault, M.C., Grote, V., Kaaks, R., Boeing, H., Naska, A., Adarakis, G., Valanou, E., Palli, D., Sieri, S., Tumino, R., Vineis, P., Panico, S., Bueno-de-mesquita, H.B., Siersema, P.D., Peeters, P.H., Weiderpass, E., Skeie, G., Engeset, D., Quirós, J.R., Zamora-Ros, R., Sánchez, M.J., Amiano, P., Huerta, J.M., Barricarte, A., Johansen, D., Lindkvist, B., Sund, M., Werner, M., Crowe, F., Khaw, K.T., Ferrari, P., Romieu, I., Chuang, S.C., Riboli, E., and Jenab, M.
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biliary tract neoplasms, dietary carbohydrate, dietary fiber, glycemic index, hepatocellular carcinoma, liver neoplasms - Abstract
Background: The type and quantity of dietary carbohydrate as quantified by glycemic index (GI) and glycemic load (GL), and dietary fiber may influence the risk of liver and biliary tract cancers, but convincing evidence is lacking. Patients and methods: The association between dietary GI/GL and carbohydrate intake with hepatocellular carcinoma (HCC; N = 191), intrahepatic bile duct (IBD; N = 66), and biliary tract (N = 236) cancer risk was investigated in 477 206 participants of the European Prospective Investigation into Cancer and Nutrition cohort. Dietary intake was assessed by country-specific, validated dietary questionnaires. Hazard ratios and 95% confidence intervals were estimated from proportional hazard models. HBV/HCV status was measured in a nested case-control subset. Results: Higher dietary GI, GL, or increased intake of total carbohydrate was not associated with liver or biliary tract cancer risk. For HCC, divergent risk estimates were observed for total sugar = 1.43 (1.17-1.74) per 50 g/day, total starch = 0.70 (0.55-0.90) per 50 g/day, and total dietary fiber = 0.70 (0.52-0.93) per 10 g/day. The findings for dietary fiber were confirmed among HBV/HCV-free participants [0.48 (0.23-1.01)]. Similar associations were observed for IBD [dietary fiber = 0.59 (0.37-0.99) per 10 g/day], but not biliary tract cancer. Conclusions: Findings suggest that higher consumption of dietary fiber and lower consumption of total sugars are associated with lower HCC risk. In addition, high dietary fiber intake could be associated with lower IBD cancer risk. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
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- 2013
50. Body weight gain and risk of colorectal cancer:a systematic review and meta-analysis of observational studies
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Schlesinger, S, Lieb, W, Koch, M, Fedirko, V, Dahm, Christina Catherine, Pischon, T, Nöthlings, U, Boeing, H, and Aleksandrova, K
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meta-analysis ,body weight gain ,colorectal neoplasms ,observational studies - Abstract
While the relationship between body mass index as an indicator of excess body weight and the risk of colorectal cancer (CRC) is well established, the association between body weight gain in adulthood and risk of CRC remains unresolved. We quantified this association in a meta-analysis of 12 observational studies published until November 2014 with a total of 16,151 incident CRC cases. Random effect models were used to obtain summary relative risks (RR) and 95% confidence intervals (95% CIs). Between-study heterogeneity was assessed using I(2) statistics. Overall, the summary RR (95% CI) was 1.22 (1.14-1.30) for high body weight gain (midpoint: 15.2 kg) compared with stable weight (P for heterogeneity = 0.182; I(2) = 21.2%). In a dose-response analysis, each 5 kg weight gain was associated with a 4% (95% CI: 2%-5%) higher risk of CRC. The association persisted after adjustment for body weight at younger age and was present for both men and women, as well as for colon and rectal cancer. Differences by sex were detected for colon cancer (P for interaction = 0.003, with higher risk for men than women), but not for rectal cancer (P for interaction = 0.613). In conclusion, these data underscore the importance of body weight management from early adulthood onwards for the prevention of CRC development.
- Published
- 2015
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