Search

Your search keyword '"Núñez, J.F."' showing total 17 results
Start Over Author "Núñez, J.F."
17 results on '"Núñez, J.F."'

7. [Accepted Manuscript] Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR <45 mL/min/1.73 m2)

Author

Farrington, K., Covic, A., Aucella, F., Clyne, N., de Vos, L., Findlay, A., Fouque, D., Grodzicki, T., Iyasere, O., Jager, K.J., Joosten, H., Macias, J.F., Mooney, A., Nitsch, D., Stryckers, M., Taal, M., Tattersall, J., Van Asselt, D., Van den Noortgate, N., Nistor, I., Van Biesen, W., ERBP guideline development group, ., COLLABORATORS, De Vos, L., Núñez, J.F., van Asselt, D., and Van Den Noortgate, N.

Published
2016

8. ¿Son modificables las actitudes hacia las personas mayores en estudiantes de medicina?: Experiencia en la Universidad de Salamanca

Author

Bernardini, D.A., Moraru, M., and Macías-Núñez, J.F.

Subjects
Actitudes, Ageing, Educación geriátrica, Attitudes, Envejecimiento, Geriatric education
Abstract

Introducción. Los médicos y los estudiantes de medicina tienden a tener actitudes negativas hacia las personas mayores. En la Unión Europea, sólo el 50% de los estudiantes de medicina reciben formación en medicina geriátrica. Sujetos y métodos. Se evaluaron las actitudes hacia las personas mayores en la cohorte de estudiantes de medicina de 5.º del curso 2006-07 inscritos en la asignatura de geriatría, al comienzo y al fin de la misma. Se utilizó un cuestionario basado en la escala diferencial semántica de Rosencranz et al, donde las puntuaciones bajas indican actitudes más positivas. Resultados. Se obtuvieron datos de 93 estudiantes, 74% fueron mujeres y 26% varones. El promedio de edad fue 22,4 años. Se apreció una mejoría en la mayoría de las variables evaluadas, con diferencias significativas en 21 de las 32 variables analizadas. Sólo el 15% declaró haber recibido un entrenamiento previo en el área del envejecimiento. Conclusiones. La exposición a conocimientos y prácticas basadas en la atención y cuidado de las personas mayores modificarían positivamente las actitudes de los estudiantes de medicina. Introduction. Both physicians and medical students show negative attitudes towards older people. In the European Union, only about 50% of the medical students receive geriatric medicine training. Subjects and methods. Attitudes towards elder people were evaluated in medical students in the fifth year of their studies during 2006-07 academical year, before and after receiving specific training in geriatric medicine. To measure attitudes we used the instrument developed by Rosencranz et al, which incorporates the Aged Semantic Differential; low scores show positives attitudes. Results. 93 questionnaires were filled in correctly; 74% of the participants were women and 26% men. Average age was 22.4 years. Our results shows lower values in the majority of the 32 variables studied, with statistically significant differences in 21 of them. Only 15% of the participants declared to have received geriatric medicine training before our study. Conclusions. Medical students' exposure to knowledge and practice in elderly care could positively modify their attitudes.

Published
2009

17. E3: EVALUATION OF THE EFFECT OF DIFFERENT DEGREES OF ADSORPTION TO ALUMINIUM HYDROXIDE ADJUVANT ON THE IMMUNE RESPONSE OF DIPHTHERIA AND TETANUS TOXOIDS ADSORBED VACCINES.

Author

Chovel, M.L., Mandiarote, A., Muñoz, M., Lara, M., Núñez, J.F., and Valle, O.

Subjects
*ALUMINUM hydroxide, *IMMUNOLOGICAL adjuvants, *IMMUNE response, *DIPHTHERIA vaccines, *TETANUS vaccines, *VACCINES
Abstract

Maximizing the immune response by adsorption of an Aluminium-containing adjuvant has been a major goal of vaccines formulation since decades. It has been demonstrated that a complete adsorption may enhance antigen uptake and ensure activation of the dendritic cells that have taken up vaccine antigens. Some time ago, WHO stated an 80 % of adsorption to Aluminium salts as a desirable specification. However, several recent studies indicate that the percent of the antigen dose that was adsorbed in the vaccine was not proportionally related to the immune response. Today, the determination of the degree of adsorption is a not a routine quality control assay for the vaccine lot release, so there is no a clear idea on the relationship between the percent of antigen adsorbed and the vaccine immunogenicity. The present work aimed to explore this relationship in order to monitor how much adsorbed should be Tetanus and Diphtheria Toxoids to Aluminium hydroxide to reach the potency test specifications. For that, samples with different adsorption degrees, both by adding lower amounts of adjuvant as by adding phosphate groups, were prepared and analysed by immunization of mice. The sera obtained were evaluated by ELISA and in vivo Potency tests. We demonstrated that samples with different percents of adsorption (between 30 and 80 %) produced acceptable in vivo potency results and antibody levels (³ 21U/mL). This study allowed a better understanding of the incidence of the adsorption process on the biological activity of Tetanus and Diphtheria Toxoid vaccines in order to use this parameter as a routine vaccine control tool. [ABSTRACT FROM AUTHOR]

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results