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BackgroundThe Scoliosis Research Society-22 (SRS-22) is a widelyused instrument to measure clinical outcomes inpatients with scoliosis. The comparison of domainscores in the SRS-22 between thoracic curve and lum-bar/thoraco-lumbar curve has not been previouslyreported.AimThe purpose of this study is to evaluate the comparisonof domain scores in the SRS-22 between thoracic curveand lumbar/thoraco-lumbar curve in patients with ado-lescent idiopathic scoliosis (AIS).MethodsThis is a cohort of 43 patients (all female) with AIS whounderwent posterior spine fusion. The patients weredivided into two group which were thoracic curve group(n=30, Lenke 1, 2, 3, 4) with a mean age of 14.6 years anda mean Cobb angle of 54° and lumbar/thoraco-lumbargroup (n=14, Lenke 5, 6) with a mean age of 14.6 yearsand a mean Cobb angle of 56° Each was compared for pre-operative SRS-22 domain scores.ResultsIn the thoracic curve group, the pre-operative mean valuesof appearance, activity, pain, mental, and sub-total were asfollows: 2.8±0.5, 4.4±0.5, 4.1±0.4, 3.8±0.9, and 3.8±0.4,respectively. In the lumbar/thoraco-lumbar curve group,the preoperative mean values of appearance, activity, pain,mental, and sub-total were as follows: 2.7±0.5, 4.0±0.8,3.8±0.9, 3.9±0.9, and 3.6±0.5, respectively. The pre-operative mean domain score of activity in the lumbar/thoraco-lumbar curve group was significantly smallercompare with that in the thoracic curve group (p=0.04).ConclusionThe pre-operative domain scores of appearance, painand mental were almost the same; however, the pre-operative mean domain score of activity in the lumbar/thoraco-lumbar curve group was significantly smallercompared with that in the thoracic curve group.