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Your search keyword '"N-(1-napthyl) ethylenediamine dihydrochloride"' showing total 3 results
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3 results on '"N-(1-napthyl) ethylenediamine dihydrochloride"'

1. Spectrophotometric method for determination of atazanavir sulfate in capsule dosage form

Author

Anindita Behera, Swapan Kumar Moitra, Sudam Chandra Si, and Dannana Gowri Sankar

Subjects
Atazanavir sulphate, 3-Methyl Benzothiazolin-2-one hydrazone, N-(1-napthyl) ethylenediamine dihydrochloride, Chemistry, QD1-999
Abstract

Two sensitive and simple spectrophotmetric methods were developed for determination of Atazanavir Sulfate in capsule dosage form. The first method was based on the oxidative coupling of ATV with 3-Methyl Benzothiazolin-2-one hydrazone (MBTH). The resulting green product had Λmax of 627.3 nm and was stable for 2 h. The second method was based on the reaction between diazotized drug with N-(1-napthyl)ethylenediamine dihydrochloride (NEDA) in neutral medium to yield yellowish orange product which had Λmax of 517.1 nm. The product was stable for 4 h. Both methods were highly reproducible and had been applied to pharmaceutical preparations.

Published
2011
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2. Spectrophotometric method for the determination of chromium (VI) in water samples.

Author

Nagaraj, P., Aradhana, N., Shivakumar, Anantharaman, Shrestha, Ashwinee Kumar, and Gowda, Avinash K.

Subjects
SPECTROPHOTOMETRY, HEXAVALENT chromium, WATER analysis, DAPSONE, ABSORPTION, HYDROXYLAMINE, ETHYLENE
Abstract

A simple and sensitive spectrophotometric method for the determination of chromium has been developed. The method is based on the diazotization of Dapsone in hydroxylamine hydrochloride medium and coupling with N-(1-Napthyl) Ethylene Diamine Dihydrochloride by electrophilic substitution to produce an intense pink azo-dye, which has absorption maximum at 540 nm. The Beer’s law is obeyed from 0.02-1.0 μg mL−1 and the molar absorptivity is 3.4854 L mol−1 cm−1. The Limits of quantification and Limit of detection of the proposed method are 0.0012 μg mL−1 and 0.0039 μg mL−1 respectively. The method has been successfully applied for the determination of chromium in water samples and the results were statistically evaluated with that of the reference method. [ABSTRACT FROM AUTHOR]

Published
2009
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3. Spectrophotometric method for determination of atazanavir sulfate in capsule dosage form

Author

Swapan K. Moitra, Sudam Chandra Si, Dannana Gowri Sankar, and Anindita Behera

Subjects
Drug, Chromatography, Chemistry, media_common.quotation_subject, 3-Methyl Benzothiazolin-2-one hydrazone, General Chemistry, Capsule Dosage Form, Pharmacology, High-performance liquid chromatography, Atazanavir Sulfate, Bioavailability, lcsh:Chemistry, Blood serum, lcsh:QD1-999, Blood plasma, medicine, Ritonavir, Atazanavir sulphate, N-(1-napthyl) ethylenediamine dihydrochloride, medicine.drug, media_common
Abstract

1used in the treatment of human immunodeficiency virus (HIV) Type II infection. ATV is re ported as poorly water soluble and a known substrate for both hepatic metabolizing enzyme Cytochrome 450 (CYP3A) and intestinal drug efflux pump, P-glycoprotein (Pgp) so have low oral bioavailability. 2 So co-administration of small dose of Ritonavir (RTV) is recommended as booster. This new drug is official in IP - 2010, but not included in BP or USP. The reported analytical methods for the determination of ATV are based on high performance liquid chromatography (HPLC) 3-12 in biological samples like blood plasma, biological cells, cerebrospinal fluid (CSF) and blood serum. Stress degradation studies were reported analysed by HPLC and ultraviolet spectrophotometry. 13, 14 The present work was aimed to develop a visible spectrophotometric method, which is simple, sensitive, accurate and cost effective to evaluate the quality of the bulk and pharmaceutical formulations. The novelties of the developed methods are that the reagents used in both the methods are easily available and the mechanisms of reactions of the reagents are already well established. The reactions involved with these reagents are simple, rapid and sensitive. Spectrophotometric methods involve simple instrumentation which is cost effective as compared to other instrumental techniques. The present method involves the determination of ATV, which is a second line drug for treatment of type II HIV infection. Still now, the 2 nd line drugs are available at higher price, than the 1 st line drugs. The high

Published
2011

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