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73 results on '"N. Del Bono"'

1. Mediators in Bronchial Provocation Tests

Author

L. Del Bono and N. Del Bono

Subjects
Submucosal glands, biology, business.industry, Degranulation, Vasodilation, respiratory system, medicine.disease, Immunoglobulin E, respiratory tract diseases, Allergic inflammation, Bronchospasm, Atopy, Immunology, medicine, biology.protein, medicine.symptom, business, Asthma
Abstract

Three major pathogenetic components characterize bronchial asthma: (1) atopy, i.e., increased levels of IgE and increased degranulation of mast cells and basophils triggered by IgE-mediated or non-IgE-mediated stimuli; (2) allergic inflammation, which damages to varying extents the bronchial wall components (epithelium, vessels, submucosal glands, respiratory nerve endings, and smooth muscle); (3) bronchial hyperreactivity (BH) to physical, chemical, and allergic stimuli, which trigger bronchial obstruction by bronchospasm, vasodilation, mucosal edema, and mucous hypersecretion.

Published
1993
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2. Aspetti metodologici dei test basati sull'inalazione di nebbia ultrasonica di acqua distillata

Author

a cura di L Del Bono e N Del Bono, Ciappi, G, Mormile, Flaminio, Chiappini, F, Bisbano, A, F Mormile (ORCID:0000-0003-0790-3272), a cura di L Del Bono e N Del Bono, Ciappi, G, Mormile, Flaminio, Chiappini, F, Bisbano, A, and F Mormile (ORCID:0000-0003-0790-3272)

Abstract

The methodology, significance and clinical importance of the bronchial challenge based on the inhalation of an ultrasonic mist of distilled water is discussed in detail

Published
1990

3. Aerosolized clenbuterol (NAB 365) and salbutamol in exercise-induced asthma

Author

C. Vibelli, F. Quartieri, and N. Del Bono

Subjects
Adult, Male, Time Factors, Adolescent, medicine.drug_class, Physical Exertion, Placebo, Bronchodilator, medicine, Humans, Albuterol, Clenbuterol, Child, Asthma, Aerosols, Exercise-induced asthma, Inhalation, business.industry, Hemodynamics, General Medicine, medicine.disease, Crossover study, Respiratory Function Tests, respiratory tract diseases, Ethanolamines, Anesthesia, Salbutamol, Female, business, medicine.drug
Abstract

The effect of clenbuterol (NAB 365) in inhibiting exercise-induced asthma was compared with that of salbutamol in a single-blind, placebo-controlled, crossover study. Single doses of 20 microgram clenbuterol and 200 microgram salbutamol were given by inhalation 180 minutes before exercise to 9 patients. The exercise used was treadmill running. Clenbuterol offered complete protection to 7 patients, partial protection to 1 and no protection to 1 patient. Salbutamol offered complete protection to 5 patients, partial protection to 1 and no protection to 3 patients. One patient was not protected by any treatment. The protective effects of the two beta-adrenergic bronchodilator drugs were similar (p = 0.42 for FEV1 and p = 0.10 for FEF25-75%). Placebo failed to prevent exercised-induced asthma in any patient. No adverse reactions were manifested or reported by the patients.

Published
1979
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4. Cold-Air Isocapnic Hyperventilation Test in the Study of the Effects and Duration of Action of Duovent

Author

N. Del Bono, L. Del Bono, and F.L. Dente

Subjects
Pulmonary and Respiratory Medicine, business.industry, Cold air, medicine.disease, Bronchospasm, Test (assessment), Anesthesia, Hyperventilation, medicine, Bronchitis, Antiasthmatic drugs, medicine.symptom, business, Bronchial hyperreactivity
Abstract

The cold-air isocapnic hyperventilation (CAIH) test is a challenge test for non-specific bronchitis which was recently incorporated into the study of bronchial hyperreactivity. As it is easy to perfor

Published
1986
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5. Contents, vol. 50, Supplement 2, 1986

Author

M. Noto, S. Shimura, W. Shaqadan, M. Pasargiklian, G. Ciappi, P. Guerzoni, J.G. Widdicombe, A.W. Bodas, W. Fasano, S.M. Distefano, Helen Ramsdale, J.P. Delwiche, R. Carnimeo, A. Mistretta, Giorgio Segre, Virginia De Rose, C. Sena, Esko Huhti, Peter Sterk, C. Tantucci, Jorge Torres, N. Alessi, Patrizia Mangiarotti, G. Peralta, N. Del Bono, P. Carnicelli, L. Cervone, M.P. Foschino Barbaro, S. Bianco, P. Gaicomelli, Ulf Pipkorn, C. Vancheri, H. Inoue, V. Massei, Enrico Maggi, M. Robuschi, E. Angelici, P. Magnini, R. Barnabè, P. Hedqvist, A. Bisetti, G. Funaro, F. Cresci, Giuliana Gialdroni Grassi, J. Garcia Barbal, S. Valente, Y. Shimizu, G.E. Marlin, B. Jenner, W. Hida, A. Pesci, E. Fornai, F. Peccini, J. Prignot, N. Pulerà, O. Taguchi, Robert M. Naclerio, L. Marazzini, Y. Okazaki, R. Pinto, Peter J. Barnes, M. Scarpitta, Robert P. Schleimer, F.L. Dente, C. Cavalieri, G. Fontana, G. Bertorelli, W.T. Ulmer, P. Noceti, S. Sensi, J. Diaz, J.A. Nadel, J. Lulling, R. Pulejo, C. Serra, L. Toscano, G. Culla, V. Bellia, G. De Cataldis, Sven-Erik Dahlén, J. Crane, F. Madsen, S. Carlone, N. Crimi, L. Frølund, A.L. De Masi, M. Cervone, G. Virgili, A. Vaghi, Myrna Dolovich, H. Sasaki, P. Panuccio, K.B.P. Leung, A. Grieco, Kari Sahlström, M. Mugnai, F. Bergero, F. Bariffi, B. Cacopardo, T. Takishima, Pietro Zanon, Frederick E. Hargreave, F. Palermo, S. Mirabelli, G.H. Russo, H. Nogami, A. Santolicandro, M. Rossi, P.A. Frith, Gian Franco Del Prete, L. Del Bono, T. Sasaki, D. Pérez, P.E.P. Dubois, C. Giuntini, E Adelroth, L. Del Torre, Stephen C. Lazarus, M. Lelli, C.A. Bellía, S. De Luca, K.C. Flint, A. Sanduzzi, J. Brostoff, Juan Antonio Mazzei, Mario Ricci, A. Petraglia, L. Romano, N.McI. Johnson, Anna Fietta, R.C. Calvanese, C.M. Sanguinetti, E.R. McFadden, P. Palange, Stephen P. Peters, D. Ansalone, Elisabeth Granström, J.L. Calpe, U.G. Svendsen, B. Mastropasqua, Warren M. Gold, M. Bozzoni, B. Bruni, P. Simone, F. Patalano, D.C. Flenley, Risto Härkönen, P. Minette, B. Weeke, G. Garofalo, E. Longhini, A. Baronti, G.N. Colasurdo, V. Picca, Lawrence M. Lichtenstein, Kari Alanko, G. Bonsignore, A. Mori, M. Moretti, Sergio Romagnani, R. Aquilina, C. Ciccarello, L. Cecere, Paul M. O'Byrne, C.F. Marchioni, O. Resta, D. McIntosh, F.L. Pearce, G. Luciani, A. Giacopelli, P. Vergara, T. Todisco, E. Servera, M. Newhouse, J. Atkinson, P. Serra, S. Gasparini, G. De Matthaeis, John M. Shneerson, B.N. Hudspith, Maria Kumlin, M. Pirrelli, Donald W. MacGlashan, S. Macaluso, N. Carnimeo, F. De Benedetto, E. Marangio, G. Migliara, M.E. D’Amore, G.M Corbo, M. Marchioni, Carlo Grassi, J. Marín, Anneli Poukkula, and V. Grassi

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1986
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6. Bronchodilator Effect of Tiaramide Hydrochloride

Author

F. Sconosciuto, L. Del Bono, and N. Del Bono

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.drug_class, Hydrochloride, Pharmacology, Placebo, Piperazines, chemistry.chemical_compound, Double-Blind Method, Bronchodilator, mental disorders, medicine, Humans, Bioassay, Benzothiazoles, Lung Diseases, Obstructive, Aged, Asthma, business.industry, organic chemicals, Middle Aged, medicine.disease, Obstructive lung disease, Bronchodilator Agents, Respiratory Function Tests, Bronchodilator Effect, Thiazoles, chemistry, Anesthesia, Female, business
Abstract

A bioassay with tiaramide hydrochloride (THC) and placebo was performed in 32 non-asthmatic patients suffering from chronic obstructive lung disease. Each patient received one administration of THC (200 mg) and one of placebo according to a double-blind cross-over design. FVC, FEV1, FM25-75, PEF and FEF200-1,200 were measured before and at several intervals until 360 min after treatment. Significant differences were found between drug and placebo which gave no significant variations. It is concluded that THC is an effective and safe bronchodilator. The substained bronchodilator effect shown by THC appears to be a clinical advantage.

Published
1981
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7. NHLBI-CNR Workshop on ‘Usefulness and Perspectives of Bronchoalveolar Lavage’, Parma, June 13-14, 1988

Author

Li Deqin, Mirco Lusuardi, M. Carrión, C. Agustí, A. Agustí-Vidal, C. Le Merre, Takao Shimizu, Satoshi Kitamura, Nobuo Ohya, G.A. Fontana, Margareta Söderberg, Nobuya Ohishi, Rune Lundgren, H.P. Pfeuffer, D.B. Teculescu, R. Stoohs, John M. Patrick, S. Cardellicchio, G. Cumming, W.D. Heine, A. Xaubet, F. Raschke, Hirohisa Toga, Ch. Préfaut, Toshiharu Fukunaga, Gutti Madan Mohan Rao, J. Pino-Repetto, Lutfia Omar Morghom, J.C. Ansquer, Jyongsu Huang, S. Damato, J.A. Martos, Elisa L. Spada, H.J. Viereck, Claudio F. Donner, Paweł ⋅liwiński, A. Kublik, Shigeru Sakurai, V. Boddi, Takashi Izumi, Xie Zhonglin, W. Castellani, Hideki Yotsumoto, V. Grassi, A. Morgenroth, Fumimaro Takaku, Andrea Sbaffi, Anna Tinivella, Keiichiro Takase, M.J. Clark, C. Picado, G. Comis, N. Del Bono, Krzysztof Skwarski, Sonia Carli, Dorota Górecka, Masoud-Sherif R. Mukhtar, Sun Bingyoun, B. Hannhart, Jan Zieliński, Sergio Zaccaria, S. Gueréquiz, Yukihiko Sugiyama, B. Panuccio, E Ferrante, N. Zouari, S. Bianco, P. von Wichert, J.V. Cereceda-Pedreros, U. Orefice, and M. Tafil-Klawe

Subjects
Lung Diseases, Male, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Physiology, Congresses as Topic, Respiratory Function Tests, Bronchoalveolar lavage, Evaluation Studies as Topic, medicine, Humans, Multicenter Studies as Topic, Female, business, Bronchoalveolar Lavage Fluid
Published
1989
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8. Contents Vol. 42, 1981

Author

W. Petro, Procházka J, Paul T. Rodeghero, Ronald D. Fairshter, L. Del Bono, Dietrich Kandt, V. Pelouch, P. Vanderhoeft, Archie F. Wilson, J. Widimský, S. Westaby, F. Sconosciuto, Giorgio Scano, Ingrid Sehrt, Ressl J, Alan Tucker, Paul M. Suratt, Antharvedi Anne, U. Smidt, Donna M. Hooe, N. Del Bono, David A. Owens, Urbanová D, G.v. Nieding, Roger Sergysels, C.K. Connolly, Heinrich Ivainsky, W. Böll, J. Bruyns, A. Van Meerhaeghe, Michael P. Habib, B. Ošťádal, and P. Lockwood

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1981
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10. Cold-air isocapnic hyperventilation test in the study of the effects and duration of action of Duovent. Comparison with fenoterol, salbutamol, disodium cromoglycate and placebo

Author

F L, Dente, L, Del Bono, and N, Del Bono

Subjects
Adult, Male, Adolescent, Bronchial Spasm, Air, Ipratropium, Carbon Dioxide, Asthma, Bronchial Provocation Tests, Cold Temperature, Drug Combinations, Cromolyn Sodium, Humans, Hyperventilation, Albuterol, Female, Atropine Derivatives, Fenoterol
Abstract

The cold-air isocapnic hyperventilation (CAIH) test is a challenge test for non-specific bronchitis which was recently incorporated into the study of bronchial hyperreactivity. As it is easy to perform and to reproduce, the CAIH test is regarded as a valuable examination in clinical pharmacology. We carried out a study using this test in 12 atopic asthmatics in intercritical phase. The patients were treated for a few days before, under double-blind conditions and random order, with Duovent (80 micrograms ipratropium bromide + 200 micrograms fenoterol), fenoterol (400 micrograms), salbutamol (200 micrograms), disodium cromoglycate (DSCG) (10 mg) and placebo. All the drugs were administered by aerosol 30 min before the test which was repeated at intervals of 120, 240 and 360 min after intake of the drug. Certain parameters of respiratory function were measured by dry spirometry (Vicatest 2 C) before administration of the drug as well as before and 0, 3, 5, 15, 30 and 60 min after each test. For the sake of brevity only the FEV1 values are shown in the figures since the other parameters all revealed a similar pattern. After placebo, all the patients reacted to the CAIH test with significant falls after each of the 4 tests, but there was no statistically significant difference between the 4 tests; there were no statistically significant differences between the pretreatment values in FEV1 recorded before each treatment (verum or placebo).(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1986

13. Effectiveness of nedocromil sodium versus placebo as additions to routine asthma maintenance therapy: a multicentre, double-blind, group comparative trial

Author

V. Grassi, U. Orefice, N. Del Bono, and S. Bianco

Subjects
Pulmonary and Respiratory Medicine, Nedocromil, Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Quinolones, Placebo, Maintenance therapy, Double-Blind Method, medicine, Humans, Nedocromil Sodium, Asthma, Aged, Maximal Expiratory Flow Rate, Randomized Controlled Trials as Topic, Chemotherapy, Inhalation, business.industry, Anti-Inflammatory Agents, Non-Steroidal, respiratory system, Middle Aged, medicine.disease, respiratory tract diseases, Surgery, Clinical trial, Anesthesia, Female, business, medicine.drug
Abstract

A total of 117 subjects took part in a double-blind, placebo-controlled trial of nedocromil sodium (4 x 4 mg daily by inhalation) in the management of patients with moderately severe bronchial asthma. Treatment was randomly allocated and was continued for 12 weeks following a 2-week baseline period on routine asthma therapy. Statistically significant differences for nedocromil sodium versus placebo were found for diary card asthma severity scores, morning and evening peak flow measurements and daily bronchodilator usage. The clinicians' assessments of asthma severity and global opinions of treatment efficacy were also significantly in favour of nedocromil sodium. Overall, the clinical status of these asthmatic patients was improved by adding nedocromil sodium onto their existing therapy.

Published
1989

14. Comments on acute studies

Author

N. Del Bono

Subjects
Pulmonary and Respiratory Medicine, Bronchial Spasm, business.industry, Ipratropium, Physical Exertion, Parasympatholytics, respiratory system, Ipratropium bromide, Adrenergic beta-Agonists, Bronchial Provocation Tests, chemistry.chemical_compound, Drug Combinations, chemistry, Bromide, Anesthesia, medicine, Terbutaline, Humans, Drug Therapy, Combination, Atropine Derivatives, business, Fenoterol, medicine.drug
Abstract

Sixteen papers which have examined the effects of Duovent (a combination of fenoterol 200 micrograms and ipratropium bromide 80 micrograms) in the treatment and prevention of bronchospasm by acute studies are reviewed. The studies suggest that the use of a combination of anticholinergic and beta 2-adrenergic drugs is justified, because the dominant mechanism in bronchospasm is the effect of acetylcholine on muscarinic receptors and because ipratropium bromide increases the action of fenoterol, so as to obtain prolonged bronchospasmolytic and antibronchoconstrictive effects with halved doses of beta 2-agonist.

Published
1986

38. Subject Index, Vol. 56, 1989

Author

Mirco Lusuardi, N. Del Bono, S. Cardellicchio, Satoshi Kitamura, Dorota Górecka, Sergio Zaccaria, Lutfia Omar Morghom, Toshiharu Fukunaga, S. Damato, C. Agustí, W.D. Heine, M. Carrión, Nobuo Ohya, Claudio F. Donner, Shigeru Sakurai, Nobuya Ohishi, Margareta Söderberg, Sonia Carli, G. Cumming, J. Pino-Repetto, S. Gueréquiz, Yukihiko Sugiyama, John M. Patrick, Krzysztof Skwarski, J.V. Cereceda-Pedreros, A. Agustí-Vidal, H.P. Pfeuffer, Takao Shimizu, Hideki Yotsumoto, Masoud-Sherif R. Mukhtar, Sun Bingyoun, N. Zouari, C. Picado, G. Comis, B. Panuccio, Xie Zhonglin, D.B. Teculescu, R. Stoohs, B. Hannhart, S. Bianco, Paweł ⋅liwiński, U. Orefice, E Ferrante, A. Kublik, A. Morgenroth, Takashi Izumi, Hirohisa Toga, M. Tafil-Klawe, F. Raschke, Jyongsu Huang, Jan Zieliński, G.A. Fontana, V. Boddi, C. Le Merre, Anna Tinivella, P. von Wichert, A. Xaubet, J.A. Martos, Gutti Madan Mohan Rao, J.C. Ansquer, Li Deqin, V. Grassi, Elisa L. Spada, Ch. Préfaut, Keiichiro Takase, M.J. Clark, W. Castellani, Fumimaro Takaku, Andrea Sbaffi, Rune Lundgren, and H.J. Viereck

Subjects
Pulmonary and Respiratory Medicine, Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1989
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39. Subject Index Vol. 42, 1981

Author

U. Smidt, Ressl J, David A. Owens, W. Böll, Ronald D. Fairshter, Archie F. Wilson, C.K. Connolly, J. Widimský, L. Del Bono, P. Lockwood, W. Petro, G.v. Nieding, Giorgio Scano, F. Sconosciuto, Heinrich Ivainsky, Antharvedi Anne, V. Pelouch, Procházka J, P. Vanderhoeft, Ingrid Sehrt, A. Van Meerhaeghe, Michael P. Habib, Donna M. Hooe, B. Ošťádal, Urbanová D, Roger Sergysels, Alan Tucker, Paul M. Suratt, Paul T. Rodeghero, S. Westaby, N. Del Bono, J. Bruyns, and Dietrich Kandt

Subjects
Pulmonary and Respiratory Medicine, Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1981
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40. Book Review / Erratum

Author

C.K. Connolly, Dietrich Kandt, A. Van Meerhaeghe, P. Vanderhoeft, Donna M. Hooe, Alan Tucker, Archie F. Wilson, L. Del Bono, Michael P. Habib, G.v. Nieding, Procházka J, Paul M. Suratt, B. Ošťádal, J. Widimský, W. Böll, Urbanová D, Ingrid Sehrt, Paul T. Rodeghero, Ressl J, U. Smidt, W. Petro, F. Sconosciuto, S. Westaby, P. Lockwood, Roger Sergysels, Heinrich Ivainsky, Ronald D. Fairshter, Giorgio Scano, David A. Owens, N. Del Bono, Antharvedi Anne, V. Pelouch, and J. Bruyns

Subjects
Pulmonary and Respiratory Medicine, business.industry, Medicine, business, Classics
Published
1981
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41. [Fenoterol in the diagnosis and treatment of reversible bronchospasm].

Author

Sevieri GP, Quartieri F, and Del Bono N

Subjects
Adult, Albuterol therapeutic use, Asthma drug therapy, Bronchial Spasm drug therapy, Female, Humans, Lung Diseases, Obstructive diagnosis, Male, Metaproterenol therapeutic use, Middle Aged, Terbutaline therapeutic use, Tretoquinol therapeutic use, Bronchial Spasm diagnosis, Ethanolamines therapeutic use, Fenoterol therapeutic use, Lung Diseases, Obstructive drug therapy
Published
1981

42. Intravenous NAB 365 (clenbuterol) and terbutaline in exercise-induced bronchospasm (EIB).

Author

Del Bono N, Quartieri F, and Vibelli C

Subjects
Adolescent, Adult, Blood Pressure drug effects, Forced Expiratory Volume, Heart Rate drug effects, Humans, Injections, Intravenous, Middle Aged, Placebos, Terbutaline adverse effects, Vital Capacity, Asthma drug therapy, Asthma, Exercise-Induced drug therapy, Clenbuterol administration & dosage, Ethanolamines administration & dosage, Terbutaline administration & dosage
Abstract

In a single-blind, placebo-controlled, cross-over study, the effects of intravenous 20 micrograms NAB 365 (clenbuterol) and intravenous 250 microgram terbutaline were compared in nine asthmatic patients with bronchospasm induced by exercise. The exercise consisted of treadmill running. The two beta-adrenergic bronchodilator drugs effectively prevented post-exercise bronchospasm in eight of the nine patients. The effects were superior to those in the untreated group and in the placebo-treated group. Six of the patients treated with terbutaline complained of adverse reactions (tremor, palpitation, tachycardia). No adverse reactions were observed after clenbuterol.

Published
1979
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45. Comments on acute studies.

Author

Del Bono N

Subjects
Bronchial Provocation Tests, Bronchial Spasm physiopathology, Drug Combinations administration & dosage, Drug Combinations therapeutic use, Drug Therapy, Combination standards, Fenoterol administration & dosage, Humans, Ipratropium administration & dosage, Physical Exertion, Terbutaline therapeutic use, Adrenergic beta-Agonists therapeutic use, Atropine Derivatives therapeutic use, Bronchial Spasm drug therapy, Fenoterol therapeutic use, Ipratropium therapeutic use, Parasympatholytics therapeutic use
Abstract

Sixteen papers which have examined the effects of Duovent (a combination of fenoterol 200 micrograms and ipratropium bromide 80 micrograms) in the treatment and prevention of bronchospasm by acute studies are reviewed. The studies suggest that the use of a combination of anticholinergic and beta 2-adrenergic drugs is justified, because the dominant mechanism in bronchospasm is the effect of acetylcholine on muscarinic receptors and because ipratropium bromide increases the action of fenoterol, so as to obtain prolonged bronchospasmolytic and antibronchoconstrictive effects with halved doses of beta 2-agonist.

Published
1986
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48. Effectiveness of nedocromil sodium versus placebo as additions to routine asthma maintenance therapy: a multicentre, double-blind, group comparative trial.

Author

Bianco S, Del Bono N, Grassi V, and Orefice U

Subjects
Adolescent, Adult, Aged, Double-Blind Method, Female, Humans, Male, Maximal Expiratory Flow Rate drug effects, Middle Aged, Nedocromil, Randomized Controlled Trials as Topic, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Asthma drug therapy, Quinolones therapeutic use
Abstract

A total of 117 subjects took part in a double-blind, placebo-controlled trial of nedocromil sodium (4 x 4 mg daily by inhalation) in the management of patients with moderately severe bronchial asthma. Treatment was randomly allocated and was continued for 12 weeks following a 2-week baseline period on routine asthma therapy. Statistically significant differences for nedocromil sodium versus placebo were found for diary card asthma severity scores, morning and evening peak flow measurements and daily bronchodilator usage. The clinicians' assessments of asthma severity and global opinions of treatment efficacy were also significantly in favour of nedocromil sodium. Overall, the clinical status of these asthmatic patients was improved by adding nedocromil sodium onto their existing therapy.

Published
1989
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