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6 results on '"N. F. Muller"'

1. Effects of Imipenem, Cefotaxime and Cotrimoxazole on Aerobic Microbial Colonization of the Digestive Tract

Author

P. L. M. Thunnissen, J. J. J. P. M. Van Der Leur, Anton S. M. Dofferhoff, N. F. Muller, and H. A. L. Clasener

Subjects
Adult, Male, Microbiology (medical), Imipenem, Cefotaxime, medicine.drug_class, Antibiotics, Colonisation resistance, Microbiology, Feces, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Humans, Aged, Candida, Aged, 80 and over, Gram-Negative Aerobic Bacteria, General Immunology and Microbiology, biology, Pseudomonas, General Medicine, Middle Aged, biology.organism_classification, Antimicrobial, Trimethoprim, Bacteria, Aerobic, Infectious Diseases, Enterococcus, Superinfection, Female, Digestive System, medicine.drug
Abstract

Superinfections originating from a digestive tract colonized by abnormally high concentrations of aerobic microorganisms as a result of impaired resistance to colonization (CR) may complicate antibiotic therapy. In this study, patients with a moderate to severe systemic infection were randomized to receive either cefotaxime (CTX, n = 10) or cotrimoxazole (CTR, n = 10), 2 antibiotic regimens presumed to spare CR; or imipenem/cilastine (I/C, n = 19). The effect on CR was measured indirectly by comparing the aerobic faecal flora before antibiotic treatment with that on day 8 of treatment. An increase in aerobic faecal flora denotes a disturbed CR, whereas a decrease means that the organism is sensitive to the effective faecal concentration of the antibiotic. Imipenem/cilastine-treated patients showed a significant increase in enterococci and Candida spp., while the number of aerobic Gram-negative rods remained constant. Cefotaxime-treated patients had evidence of an increase in enterococci, but not of Candida spp., and Escherichia coli numbers decreased significantly. In these patients the concentration of other Gram-negative aerobic rods showed a slight increase in 6 patients with a resistant Pseudomonas strain. Cotrimoxazole-treated patients showed a significant decrease in aerobic Gram-negative rods, a significant increase in Candida spp. and no change in enterococci. It is concluded that all 3 antimicrobial agents impair colonization resistance. Whether or not this is followed by overgrowth with resistant micro-organisms depends on the active faecal concentration of the antimicrobial agent and the MIC of the aerobic micro-organisms. The risk of overgrowth of the bowel with resistant Gram-negative bacilli appears to be smaller following cotrimoxazole than following cefotaxime or imipenem/cilastine.

Published
1993
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2. Abstracts of papers Rational use of drugs

Author

M. N. G. Dukes, Robert M. Elenbaas, G. Tognoni, Dorothy L. Smith, Inga Lunde, H. G. M. Leufkens, Y. A. Hekster, A. Bakker, G. Ostino, H. Petri, F. Sturmans, H. D. Banta, F. F. H. Rutten, L. L. Martens, P. R. Noyce, F. W. H. M. Merkus, Lolkje de Jong-v.d.Berg, Flora Haaijer-Ruskamp, Graham Dukes, B. -M. Vidgren, S. Vidgren, N. Martini, M. L. Sala, G. Scroccaro, P. Olivencia, D. C. McLcod, W. G. Coln, A. G. Hartzcma, C. F. Thaver, J. M. Rodriguez-Sasiain, B. Sangroniz, M. D. Mauleon, M. A. Wood, M. J. Martinez, O. Leinebø, J. N. Saugen, P. Marini, R. Olivato, C. Alberola, E. Cruz-Martos, T. Cruz, N. Marfagon, A. Herreros de Tejada, P. Denig, F. M. Haaijer-Ruskamp, H. Wesseling, A. Versluis, M. P. Gascón, Robert Horne, Jane Hough, N. S. Klazinga, J. J. -E. van Everdingen, P. J. van den Broek, D. K. Roberts, G. B. A. Veitch, K. K. C. Tan, D. A. Holland, M. C. Allwood, A. Nicholls, A. Astobieta, R. Calvo, J. M. Rodriquez-Sasiain, D. Barriquand, C. Pochon, G. Aulagner, A. Vial, C. Dumarest, P. H. Maire, R. W. Jelliffe, J. R. B. J. Brouwers, K. Cramer, J. Gulyas, H. J. vd Kam, J. Sijtsma, C. Donadio, G. Tramonti, G. Garcea, M. Costagli, A. Lucchetti, R. Giordani, G. Paizis, R. Pierotti, G. Falcone, C. Bianchi, C. Gallastegui, R. Farré, I. Jiménez, M. A. Mangues, E. Guasch, G. Ginovart, X. Sagrera, F. Raspall, J. M. Queralto, J. M. Kovarik, C. M. A. Rademaker, J. Verhoef, L. Silvestri, M. Caputo, M. Andrew, E. -L. Toverud, I. Jimenez, I. Castro, E. Alvarez, J. Altimiras, J. J. J. P. M. van de Leur, N. F. Muller, J. M. Van Turnhout, L. Mendizabal, J. M. Rodriguez Sasiain, G. Morana, K. Moss Ofstad, A. -M. Timenes, J. K. F. Vroom, L. T. W. de Jong-van den Berg, P. B. van den Berg, J. J. de Gier, J. Ferres, O. Recoder, Rio T. Sanchez, M. P. Garcia, A. Julia, A. Balet, R. Farre, M. A. Manques, T. Berod, E. Dufay, C. Naveau, M. Combe, A. Sauvageon, Erik Wind Hansen, Jens Dencker Christensen, L. Lie-A-Huen, J. H. Kinqma, D. K. P. Meijer, F. Le Meur, P. Isoard, M. S. Salek, A. Y. Finlay, G. K. Khan, D. K. Luscombe, A. Stuurman, M. P. Boidin, K. Wallenius, R. Ojala, A. Kariluoto, M. Ikonen, A. H. P. Paes, A. Th. G. Blom, S. Wallenius, H. Enlund, K. Vainio, C. Codina, M. Roca, P. Sardà, N. Corominas, J. Massó, J. Ribas, K. Kentra, M. Myllyntausta, M. Saarenpää, M. S. A. Airaksinen, L. Mendarte, A. Rimola, R. Meisters, Y. Hekster, W. Janssen, A. Cox, R. Kempen, S. J. A. Aerdts, R. van Dalen, H. A. L. Clasener, J. Festen, PP Schjphorst, HB Benraad, P. van Asten, R. de Wit, R. J. G. Limbeek, H. G. M. Nagel, R. H. B. Mgyboom, B. H. C. Stricker, B. A. M. van den Berg, T. H. A. Nelen, T. A. G. Tijssen, P. Wassink, M. J. E. Wassink-L'Ortije, P. Gascón, C. Selva, T. Bassons, C. Pardo, M. P. Mas, M. Saqalés, F. Sánchez, V. Mercade, R. Pujol, C. Agustí, M. Cano, T. Gurrera, M. Gorchs, X. Fabregas, L. L. Murgui, A. Verdaguer, W. P. J. Witjes, E. J. Vollaard, B. J. P. Crul, C. Limpens, K. Ahonen, T. Klaukka, I. Vohlonen, J. Martikainen, Daniel Goldenberg, Andres Brodsky, Ines Aparici, Cecilia Argeri, D. Goldenberg, C. Saidman, L. Sevinski, N. Allevato, B. Mujico, J. Ubogui, P. Dorfman, Lupo L. Rodriguez, M. Varela, J. Higa, Annie Fourrier, Philippe Larrouturou, Claire Samarran, Jacqueline Huchet, N. D. Barber, N. Party, P. Wilson, Grethe Eide, Kari Horvei, Angelika Kruse-Jensen, Ingrid Wold, Turid Møark, C. W. Barrett, A. C. Tugwell, B. Søndergaard, M. Rasmussen, F. Davidsen, H. Hey, L. Kierkeby, L. Riis, M. Korhonen, P. Vidgren, T. Ojanen, M. Vidqren, J. Ferrés, T. Sanchez, C. Gallastequi, A. Julià, R. M. C. Herings, B. H. Ch. Stricker, A. J. H. H. Janssen, Heike Dinter, A. J. H. M. Janssen, X. Barbaut, S. Proust, G. Amlagner, F. A. L. M. Eskens, E. Arnoldussen, E. Sieradzki, E. Wanat-Słupska, M. Zlółkowska, I. Pankowska, R. Mazur, B. Ksiazkiewicz, A. Jankowski, A. Marzec, C. Marzec, M. O. Marzec, J. P. Marzec, D. R. Mungall, Lynne Portnoy, F. Lucas, F. Kadir, A. Pijpers, A. Vulto, J. Zuidema, P. Sutton, Antal Samu, John E. Murphy, Ronnie Chapman, Nicolien Wieringa, J. Rolloos, M. T. P. J. Voesten, P. J. J. de Meijer, G. H. P. de Koning, S. Salek, E. Reerink, L. Farrow, G. Raskob, D. Rosenbloom, R. Hull, A. Torras, O. Recorder, C. Torras, J. Cubellsl, M. Font, R. Madridejos, A. Catalán, M. Huguet, N. Franquesa, J. Gratacós, M. Martinez, A. Saltó, E. van der Kleijn, R. J. M. ter Wee, N. Holmberg, and R. F. Brenninkmeijer

Subjects
Pharmacology, Medical education, business.industry, Pharmacology (medical), Pharmacy, business, Psychology, Rational use
Published
1989
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3. Systemische profylaxe met antibiotica in de chirurgie

Author

H. J. M. Joosten, E. J. Vollaard, and N. F. Muller

Subjects
Pharmacology, Gynecology, medicine.medical_specialty, business.industry, medicine, Pharmacology (medical), business
Abstract

In 1961 toondeBurke in dierexperimenten aan dat antibiotica een primaire wondinfectie slechts gunstig beInvloeden als zij voor of kort na de bacteriele contaminatie worden toegediend. Het effect is optimaal als reeds tijdens de contaminatie een effectieve weefselconcentratie van het antibioticum bestaat.

Published
1979
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4. Faecal level of urobilinogen: an indication for the risk of superinfection and of failure of oral anticonception?

Author

N. F. Muller, H. A. L. Clasener, M. M. Jankowiak, and E. J. Vollaard

Subjects
medicine.medical_specialty, Pharmaceutical Science, Colonisation resistance, Pharmacology, medicine.disease_cause, Dicloxacillin, Gastroenterology, Contraceptives, Oral, Hormonal, Feces, chemistry.chemical_compound, Pregnancy, Risk Factors, Internal medicine, Humans, Medicine, Pharmacology (medical), Norfloxacin, Urobilinogen, business.industry, Clindamycin, Drug Resistance, Microbial, Bacterial Infections, Minocycline, Anti-Bacterial Agents, chemistry, Superinfection, Female, Oestrogen metabolism, business, medicine.drug
Abstract

The influence of clindamycin, dicloxacillin, minocycline and norfloxacin on the faecal concentration of urobilinogen was investigated. The studied drugs were administered orally in standard dosage for six days to groups of six volunteers. A decrease in faecal concentration of urobilinogen following administration of clindamycin (P less than 0.01) and dicloxacillin (P less than 0.05) was found. The possible predictive value of a decrease of the faecal level of urobilinogen as an indicator for the impairment of microbial colonization resistance and for the risk of failure of oral anticonceptive treatment is discussed. It is suggested that clindamycin and dicloxacillin should not be combined with oral anticonceptive treatment unless more specific investigations have excluded interaction of these drugs with the oestrogen metabolism in the bowel.

Published
1989
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5. Influence of cefaclor, phenethicillin, co-trimoxazole and doxycycine on colonization resistance in healthy volunteers

Author

N. F. Muller, H. A. L. Clasener, A. H. J. Sanders-Reijmers, P. J. C. Huige, A. J. A. van Griethuysen, E. J. Vollaard, and A. J. H. M. Janssen

Subjects
Adult, Male, Microbiology (medical), Staphylococcus aureus, Sulfamethoxazole, medicine.drug_class, Antibiotics, Colony Count, Microbial, Colonisation resistance, Trimethoprim, Microbiology, Feces, Anti-Infective Agents, Enterobacteriaceae, Oral administration, Yeasts, Gram-Negative Bacteria, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Humans, Pharmacology (medical), Cefaclor, Antibacterial agent, Pharmacology, Doxycycline, Cephalexin, biology, Middle Aged, Antimicrobial, biology.organism_classification, Anti-Bacterial Agents, Drug Combinations, Infectious Diseases, Penicillin V, Female, medicine.drug
Abstract

The influence of oral administration of cefaclor, phenethicillin, co-trimoxazole and doxycycline on colonization resistance (CR) of the oropharynx and colon in healthy volunteers was studied. Antimicrobial agents were administered in a randomized cross-over design. No effect on CR of the oropharynx could be demonstrated. Phenethicillin decreased CR of the colon against Enterobacteriaceae (P = 0.001). Co-trimoxazole significantly decreased the concentration of Enterobacteriaceae in faeces (P = 0.03) but the decrease caused by cefaclor and doxycycline did not reach statistical significance. Administration of antimicrobial agents increased the appearance of secondary colonization by Enterobacteriaceae in faeces, especially when Escherichia coli was eliminated. During administration of phenethicillin, secondary colonization occurred at a concentration exceeding 10(7)/g in some volunteers. Following administration of cefaclor, co-trimoxazole and doxycycline, elimination of E. coli may result in the substitution by resistant Gram-negative bacilli in low concentrations.

Published
1988
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