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A 34-year-old woman from Thai origin developed acute liver failure after ingestion of a soup which contained the death cap (Amanita phalloides).In patients with poisoning due to amatoxin-containing mushrooms, gastro-intestinal complaints usually develop several hours after ingestion, followed by acute hepatic failure which occasionally leads to death. The incidence of reported mushroom poisonings in the Netherlands has increased in 2019, which is possibly associated with migration of asylum seekers who regularly pick and eat mushrooms.In the Netherlands mushroom intoxication is rare. Therefore, there is a lack of knowledge among health care personnel and foragers. The present case report highlights the importance of awareness of the poisonous death cap to prevent intoxications and optimize treatment decisions.

Purpose: The purpose of this study was to evaluate the evidence on reliability of handheld dynamometry protocols to quantify maximal isometric strength of the muscles of the lower extremities of children with cerebral palsy. Methods: A systematic search of Cochrane, MEDLINE, CINAHL, and PubMed up to December 2013 and best-evidence synthesis were performed. Results: Seven eligible studies were identified. Best-evidence synthesis revealed "unknown" to "moderate" evidence. Intraclass correlation coefficient values were "positive" for most muscle groups for intrarater reliability and showed mixed results for interrater reliability. Conclusions: Because of small sample sizes (10-25) in all included studies, the final level of evidence remains "unknown." Reliability data obtained in the included studies of handheld dynamometry in children with cerebral palsy are promising, despite low levels of evidence. When these protocols are applied very carefully, they may prove relevant to different clinical settings.

This chapter examines the range of approaches that Protestant missionaries took to their work in Ohio. In particular, it shows how Presbyterian Joseph Badger brought redemption to Ohio. Beginning in 1800, he made several journeys to proselytize in the region. Aggressively confronting the inhabitants of this “unbroken wilderness,” Badger made Ohio his own spiritual and physical frontier, a place to be transformed by the religion and culture he would impose. His approach contrasted with most immigrants to Ohio who dismissed Indians as pagans, strangers, and enemies, objects to be transformed or removed. Badger, however, detoured from the path many other Protestant proselytizers followed by sometimes befriending Native American neighbors and defending them against the onslaught of other American settlers. His efforts preserved a remnant of Ohio before it became a frontier for missionaries and settlers. Badger sustained the past compromises that had made Ohio a “middle ground,” a place where negotiations among various Europeans and Indians trumped the purposes of any one party. Badger’s competitors ran roughshod over his designs and efforts as they charged into Ohio and trampled any hope of preserving compromise.

Contents: Introduction The Indians' Old World: Native Americans and the coming of Europeans, Neal Salisbury 'This evil extends especially ...the feminine sex': negotiating captivity in the New Mexico borderlands, James F. Brookes King Philip's herds: Indians, colonists, and the problem of livestock in early New England, Virginia DeJohn Anderson Women and property across colonial America: a comparison of legal systems in New Mexico and New York, Deborah A. Rosen Taking possession and reading texts: establishing the authority of overseas empires, Patricia Seed Reading the runaways: self-fashioning, print culture, and confidence in slavery in 18th-century mid-Atlantic, David Waldstreicher 'Damned scoundrels' and 'libertisme of trade': freedom and regulation in colonial New York's fur and grain trades, Cathy Matson 'Baubles of Britain': the American consumer revolutions of the 18th century, T.H. Breen Patriarchy reborn: the gendering of authority in the evangelical Church in revolutionary New England, Susan M. Juster Food rioters and the American Revolution, Barbara Clark Smith Between slavery and freedom: Virginia blacks in the American Revolution, Sylvia R. Frey John Adams, diplomat, John Ferling Thinking like a constitution, Jack N. Rakove 'Of every age sex and condition': the representation of women in the constitution, Jan Lewis Slander, poison, whispers, and fame: Jefferson's 'Anas' and political gossip in the early republic, Joanne B. Freeman Rites of rebellion, rites of assent: celebrations, print, culture and the origins of American nationalism, David Waldstreicher Liberty, development, and union: visions of the West in the 1780s, Peter S. Onuf Thinking and believing: nativism and unity in the ages of Pontiac and Tecumseh, Gregory E. Dowd Name index.

In 2008, the UNHCR issued a convention on the rights of persons with disability. Since then, many countries were visited by the High Commissioner for Human Rights. In a number of countries, for example Germany and the Netherlands, mental health legislation was considered unsatisfactory and either regional variations in procedures or new legislation was drafted. In Germany, the final decision after different admission procedures is always made by a judge. In the Netherlands, detention on mental health ground with involuntary admission is decided by a Governmental administrator working for the local Major. In England and Wales, it is decided by three medical/psychiatric professionals. Currently, the Netherlands is drafting a law following the main principles of the Anglo-Saxon law. In Germany, all federal states are currently adopting their mental health laws to fulfil requirements of the Constitutional Court, which decided that coercive treatment is only admissible under very strict conditions after a judge's decision. Studies show the Dutch legislation is associated with higher seclusion rates, in numbers, and duration. Moreover, recent German findings show in a recent period when involuntary medication was not admissible, inpatient violence and coercive measures increased significantly. In this symposium, we discuss the several laws and regulations of four countries (Wales, Ireland, Germany, Netherlands), now and in the near future. Each presentation of a certain countries’ regulations is followed by a description of standard figures of the country, first by an expert in the respective country's law, and consequently by an expert in nationwide or regional figures.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Context The National Comprehensive Cancer Control Program (NCCCP) performance measurement system seeks to understand both the processes that funded programs undertake with their respective coalitions to implement the objectives of their cancer plans and the outcomes of those efforts. Objective To identify areas of achievement and technical assistance needs of NCCCP awardees. Design Program performance was assessed through surveys completed by program directors on performance indicators in 2009 and 2010 and queries from a Web-based management information system in 2011 and 2012. Setting Programs funded by the Centers for Disease Control and Prevention's NCCCP. Participants Sixty-nine programs. Main outcome measure(s) The key performance measures assessed were inclusion of diverse partners and key sectors in cancer coalitions, partners' involvement in activities, receiving in-kind resources from partners, using evidence-based interventions and data for setting priorities, conducting program evaluation, using community- or organization-level strategies to address cancer control efforts, and demonstrating progress toward achieving health outcomes. Results Most programs reported having active coalitions that represent diverse organizational sectors. Nearly all programs routinely assess the burden of cancer. In-kind resources to implement activities peaked at $64 716 in the second year of a 5-year funding cycle and declined in subsequent project years. By year 3, more than 70% of programs reported having an evaluation plan. While programs reported that nearly two-thirds of their interventions were evidence-based, some programs implemented non-evidence-based interventions. A majority of programs successfully used at least 1 community- or organization-level change strategy. However, many programs did not incorporate objectives linked to health outcomes as they reported progress in implementing interventions. Conclusions While NCCCP programs were strong at building and maintaining infrastructure, some programs may need additional technical assistance to increase the adoption of evidence-based interventions, develop solid and responsive evaluation plans, and better link efforts to population-based measures that demonstrate impact toward reducing the burden of cancer.

The Dutch Threatening Medical Situations Inventory (TMSI) has been developed to measure cognitive confrontation ('monitoring') and cognitive avoidance ('blunting') within the domain of medical threat. It consists of four scenarios of threatening medical situations, followed by monitoring and blunting alternatives. Its psychometric properties are investigated in students (N = 123), dental (N = 80), HIV - (N = 42) and surgery patients (N = 123). For both scales, internal consistencies proved to be satisfactory. Slight sex and age effects are found. Furthermore, there is a strong situation effect: the scenario highest in controllability shows relatively high monitoring and low blunting scores. Factor structure is stable across samples and shows a good fit with the predicted factor solution. Both scales are found to converge and diverge in a theoretically meaningful manner with a variety of coping style and anxiety measures. In two samples, a sample specific stress scenario was added, but the psychometric qualities of such an extension should not be taken for granted. In an additional sample of working people (N = 48) test-retest reliability proved to be good. It is concluded that the TMSI is a useful instrument for assessing cognitive confrontation and avoidance in medical patients. An English as well as a German translation are available. Copyright

InterPro was developed as a new integrated documentation resource for protein families, domains and functional sites to rationalize the complementary efforts of the PROSITE, PRINTS, Pfam and ProDom database projects and has applications in computational functional classification of newly determined sequences lacking biochemical characterization and in comparative genome analysis. InterPro contains over 3500 entries, with more than 1000000 hits in SWISS-PROT and TrEMBL. The database is accessible for text- and sequence-based searches at http://www.ebi.ac.uk/interpro/. InterPro was used for whole proteome analysis of the pathogenic microorganism, Mycobacterium tuberculosis, and comparison with the predicted protein coding sequences of the complete genomes of Bacillus subtilis and Escherichia coli. 64.8% of the M. tuberculosis proteins in the proteome matched InterPro entries, and these could be classified according to function. The comparison with B. subtilis and E. coli provided information on the most common protein families and domains, and the most highly represented families in each organism. InterPro thus provides a useful tool for global views of whole proteomes and their compositions.

Objectives Despite the expected health benefits of colorectal cancer screening programs, participation rates remain low in countries that have implemented such a screening program. Besides the diagnostic accuracy and the risks of the screening technique that affect the health of the participants, additional factors, such as the burden of the test, may impact the individuals' decisions to participate. The aim of this study it to explore the impact of preferences for the attributes of screening tests on intention to attend a colorectal cancer screening program. Methods We used a web-based questionnaire to elicit the preferences of Dutch men and woman aged 55 to 75 years for alternative colon screening techniques, and to measure their intention to attend the screening. The Analytic Hierarchy Process (AHP), a technique for multi-criteria analysis, was used to estimate the colorectal cancer screening preferences for iFOBT, Colonoscopy, Sigmoidoscopy and Virtual Colonoscopy. Results We included 167 respondents that were consistent in their judgments on the relevance of the criteria and the preferences for the screening techniques. The results indicate that the most preferred screening methods with the highest intention to attend were Virtual Colonoscopy and iFOBT. Sensitivity and safety of the screening methods were the strongest determinants of the overall preference for the screening techniques. However, safety and inconvenience were most strongly related to intention to attend. Conclusions Even though for the long term the respondents may recognize the high importance of diagnostic effectiveness, their short term decision to attend the screening tests appears to be less driven by this consideration. Our analysis suggests that inconvenience and safety will be the strongest technique-related determinants of the respondents' decision to participate in the new screening program in the Netherlands

Although the Great Awakening temporarily split Presbyterians into Old Side and New Side, moderation prevailed as Presbyterians tamed the New Light with their traditional emphases on clerical training, education, and theological and ecclesiastical balance. Ministers like Samuel Davies exemplified temperateness as they worked to promote religious warmth – not heat – in conversion, at the same time wresting toleration from the Anglican Church. Presbyterians concentrated their efforts within their own ethnic communities in the Shenandoah Valley and southern Piedmont, expecting potential converts to be attracted to their system and communion seasons.

Leaders of the evangelical denominations in the early nineteenth century wrote works of history and biography, beginning aggressive campaigns of publication in the midst of their competition. They wrote not only to memorialize and celebrate, using journals and memoirs from the first generation, but also to delineate the boundaries separating Presbyterians, Baptists, and Methodists and to strategically define themselves for the second generation. Struggling to counteract the inroads of competitors and schisms challenging denominational orthodoxy, apologists responded by reinforcing distinctive denominational identities. Missionary Baptists such as historians William Fristoe, Lemuel Burkitt, and Jesse Read defended Baptist associations against attacks from Primitive and anti‐Missionary Baptists, while Methodist itinerant Jesse Lee wrote to refute accusations from James O’Kelly's Republican Methodists. In the struggle over denominational identity and limits, particularity and distinction were the heart of the evangelical awakenings in the South.

Francis Asbury imposed a rigorous discipline and strict episcopacy on early American Methodists, and he envisioned a universal faith that would overwhelm the sectarian spirit that he saw prevalent in Baptist and Presbyterian churches. Following the precedents of Methodist founder John Wesley, Asbury promoted an experiential religion and holiness, accepting individual expressiveness in conversion, but demanding complete commitment from participants who were expected to pursue an ideal of perfection. They received support in class and society meetings where they could share concerns, shortcomings, and successes, and they could find models of their ideals in the selfless work of circuit riders whose example of openness and effort would trump particularity and smug complacency, Methodists hoped.

A distinct Baptist piety grew through the efforts of aggressive Calvinists who compromised the various interests of Particular, Regular, General, and Separate Baptists invading the South. Individual Baptists had to conform to this new hybrid orthodoxy, converting to meet the doctrinal standards, and measuring their religious progress according to a notion of definitive truth: believer baptism by immersion. Baptists’ congregational churches, collections of these converts, contained heated debate and close discipline that perpetuated the evaluative sensibility. In their quest for the truth, they argued, split, re‐formed, and even developed associations of churches for helpful conversation; yet these added more layers of doctrinal debate, extending the rancor and confrontation within Baptists’ insistent religiosity.

The American Revolution heightened the differences between Presbyterians, Baptists, and Methodists as the dissenters addressed the political crisis through petitions and met the resultant disestablishment of the Church of England on their own terms. Presbyterians generally embraced the Revolutionary cause, but they maneuvered primarily to achieve their long‐sought goal of gaining parity with the Anglican, now Protestant Episcopal Church, allowing for multiple establishments when the plans included Presbyterians. Baptists faced the matters resolved to maintain their absolute principles, and they were pleasantly surprised when Virginia, prompted by Thomas Jefferson's Statute for Religious Freedom, seemed to embrace some Baptist truth by striking down establishment. Francis Asbury dreamed that Methodists could stay neutral, truly separating religion from unholy matters, but he suffered when John Wesley rebuked the patriots and when most Methodist leaders fled the troubled colonies. Methodism would recover, but only by transforming into an American denomination and joining the other evangelicals already in contention for their own particular notions of religious liberty.

With the Revolutionary trauma and Anglican Church swept away, Presbyterians, Baptists, and Methodists could turn their full attention to each other as they competed for converts and ascendancy in the religiously free nation. The insular Presbyterians and Baptists struggled to keep pace with the Methodists by experimenting with some of their tactics, including warm, extemporaneous preaching, lively music, and itinerancy, yet ultimately they relied on their traditional distinctions in appeals for converts. Methodists forged ahead with their universal designs and waves of quarterly and annual meetings that fostered outdoor preaching events and camp meetings, but as they encountered their competitors, they had to define their distinctive message, and, doing so, they addressed their Calvinist rivals on the enemies’ terms: the controversial spirit that the Methodists had hoped to convert.

Laity in the audiences and congregations embraced the message of the preachers all too well during the Great Awakenings. Accounts show that men, women, Anglo‐, and African‐Americans accepted not only the general need for salvation, but also the denominations’ prescriptions for conversion. True conversion required selecting the particular beliefs of one denomination and specifically rejecting those of the others. The reborn had to turn away from false churches and teachings just as they cast aside their sinfulness. Choice, the celebrated feature of evangelical religion, emboldened laity and helped the democratization of American Christianity, but it also assured that a spirit of distinction would hover over the quarreling faithful of the South. Baptists’ oppositional religion steadily displaced Methodists’ universal faith.

International audience; InterPro (http://www.ebi.ac.uk/interpro/) is a database that integrates diverse information about protein families, domains and functional sites, and makes it freely available to the public via Web-based interfaces and services. Central to the database are diagnostic models, known as signatures, against which protein sequences can be searched to determine their potential function. InterPro has utility in the large-scale analysis of whole genomes and meta-genomes, as well as in characterizing individual protein sequences. Herein we give an overview of new developments in the database and its associated software since 2009, including updates to database content, curation processes and Web and programmatic interfaces.

A Contoversial Spirit offers a new perspective on the origins and nature of southern evangelicalism. Most recent historians have focused on the differences between evangelicals and non-evangelicals. This has led to the perception that during the "Era of Awakenings" (mid-18th and early 19th centuries) American evangelicals constituted a united front. Philip N. Mulder dispels this illusion, by examining the internal dynamics of evangelicalism. He focuses on the relationships between the Presbyterians, Baptists and Methodists who introduced the new religious mood to the South between 1740 and 1820. Although the denominations shared the goal of saving souls, he finds they disagreed over the correct definition of true religion and conversion. The Presbyterians and Baptists subordinated the freedom, innovation and experience of the awakenings to their particular denominational concerns. The Methodists, on the other hand, were more aggressive and innovative advocates of the New Light awakenings. They broke through the insularity of the other two groups and revolutionized the religious culture of the emerging nation. The American Revolution exacberated the growing competition and jealousy among the denominations by displacing their common enemy, the established Anglican church. Former dissenters now turned to face each other. Free religious competition was transformative, Mulder argues. The necessity for competing for converts forced the Presbyterians and Baptists out of their narrow confines. More importantly, however, competition compromised the Methodists and their New Light ideals. Methodists had presented themselves as an ecumenical alternative to the rigid and rancorous denominations of England and America. Now they turned away from their open message of salvation, and began using their distinctive characteristics to separate themselves from other denominations. The Methodists thus succumbed to the evangelical pattern set by others - a pattern of distinction, insularity and competition. Examining conversion narratives, worship, polity and rituals, as well as more formal doctrinal statements in creeds and sermons, Mulder is able to provide a far more nuanced portrait of southern evangelicals than previously available, revealing the deep differences between denominations that the homogenization of religious history has until now obscured.

Against a background of an I.T.C. proposal for an "Agricultural Real Time Imaging Satellite System", (ARTISS), some ideas about matching Man and Machine effort are given. Typical features of satellite MSS are reviewed. Many features other then pixel-wise Multi Spectral signatures should also be used in a classification process. Man is well equiped to use those extra features, but needs Machine help for efficient working. The aim of the ARTISS proposal is to provide developing countries with a dynamic survey system at reasonable cost. The author's ideas about the equipment for a minimum local groundstation are exposed. Implemention should use "intermediate technology", compatible with more advanced extensions in hard-and software.