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1. CVD Growth Technologies of Layered MX2 Materials for Real LSI Applications—Position and Growth Direction Control and Gas Source Synthesis

Author

T. Irisawa, N. Okada, W. Mizubayashi, T. Mori, W.-H. Chang, K. Koga, A. Ando, K. Endo, S. Sasaki, T. Endo, and Y. Miyata

Subjects
2D layered materials, MX₂, metal dichalcogenide, TMDC, CVD, gas source, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

Position and growth direction control in chemical vapor deposition (CVD) of WS2 and SnS2 by using patterned Si/SiO2 substrates has been demonstrated. It was found that step edges effectively worked as crystal nuclei and lateral crystal growth from the edges with a certain level of growth directionality was observed. Gas source CVD using industrially friendly precursors (WF6, SnCl4, and H2S) has also been developed and WS2 and SnS2 synthesis with wafer-scale uniformity have been obtained.

Published
2018
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2. Climate seasonality limits leaf carbon assimilation and wood productivity in tropical forests

Author

F. H. Wagner, B. Hérault, D. Bonal, C. Stahl, L. O. Anderson, T. R. Baker, G. S. Becker, H. Beeckman, D. Boanerges Souza, P. C. Botosso, D. M. J. S. Bowman, A. Bräuning, B. Brede, F. I. Brown, J. J. Camarero, P. B. Camargo, F. C. G. Cardoso, F. A. Carvalho, W. Castro, R. K. Chagas, J. Chave, E. N. Chidumayo, D. A. Clark, F. R. C. Costa, C. Couralet, P. H. da Silva Mauricio, H. Dalitz, V. R. de Castro, J. E. de Freitas Milani, E. C. de Oliveira, L. de Souza Arruda, J.-L. Devineau, D. M. Drew, O. Dünisch, G. Durigan, E. Elifuraha, M. Fedele, L. Ferreira Fedele, A. Figueiredo Filho, C. A. G. Finger, A. C. Franco, J. L. Freitas Júnior, F. Galvão, A. Gebrekirstos, R. Gliniars, P. M. L. D. A. Graça, A. D. Griffiths, J. Grogan, K. Guan, J. Homeier, M. R. Kanieski, L. K. Kho, J. Koenig, S. V. Kohler, J. Krepkowski, J. P. Lemos-Filho, D. Lieberman, M. E. Lieberman, C. S. Lisi, T. Longhi Santos, J. L. López Ayala, E. E. Maeda, Y. Malhi, V. R. B. Maria, M. C. M. Marques, R. Marques, H. Maza Chamba, L. Mbwambo, K. L. L. Melgaço, H. A. Mendivelso, B. P. Murphy, J. J. O'Brien, S. F. Oberbauer, N. Okada, R. Pélissier, L. D. Prior, F. A. Roig, M. Ross, D. R. Rossatto, V. Rossi, L. Rowland, E. Rutishauser, H. Santana, M. Schulze, D. Selhorst, W. R. Silva, M. Silveira, S. Spannl, M. D. Swaine, J. J. Toledo, M. M. Toledo, M. Toledo, T. Toma, M. Tomazello Filho, J. I. Valdez Hernández, J. Verbesselt, S. A. Vieira, G. Vincent, C. Volkmer de Castilho, F. Volland, M. Worbes, M. L. B. Zanon, and L. E. O. C. Aragão

Subjects
Ecology, QH540-549.5, Life, QH501-531, Geology, QE1-996.5
Abstract

The seasonal climate drivers of the carbon cycle in tropical forests remain poorly known, although these forests account for more carbon assimilation and storage than any other terrestrial ecosystem. Based on a unique combination of seasonal pan-tropical data sets from 89 experimental sites (68 include aboveground wood productivity measurements and 35 litter productivity measurements), their associated canopy photosynthetic capacity (enhanced vegetation index, EVI) and climate, we ask how carbon assimilation and aboveground allocation are related to climate seasonality in tropical forests and how they interact in the seasonal carbon cycle. We found that canopy photosynthetic capacity seasonality responds positively to precipitation when rainfall is −1 (water-limited forests) and to radiation otherwise (light-limited forests). On the other hand, independent of climate limitations, wood productivity and litterfall are driven by seasonal variation in precipitation and evapotranspiration, respectively. Consequently, light-limited forests present an asynchronism between canopy photosynthetic capacity and wood productivity. First-order control by precipitation likely indicates a decrease in tropical forest productivity in a drier climate in water-limited forest, and in current light-limited forest with future rainfall −1.

Published
2016
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3. Population dynamics of the endangered seahorse Hippocampus reidi Ginsburg, 1933 in a tropical rocky reef habitat

Author

N. Freret–Meurer, T. Fernández, N. Okada, and A. Vaccani

Subjects
Seguimiento, Estacionalidad, Peces, Syngnathidae, Brasil, Zoology, QL1-991
Abstract

Dinámica de la población del hipocampo en peligro de extinción Hippocampus reidi Ginsburg, 1933 en un arrecife rocoso tropical Este estudio se realizó en Armação de Búzios, en Brasil, un municipio en el que se ha observado la degradación de algunos ecosistemas tras el gran aumento del turismo y el crecimiento demográfico. El objetivo fue determinar las variaciones estacionales de tres poblaciones de Búzios del caballito de mar, Hippocampus reidi. Las inmersiones mensuales se realizaron entre noviembre de 2011 y octubre de 2013. Las tres subpoblaciones tenían baja densidad de caballitos de mar y carecían de estacionalidad. La razón de sexos fue diferente para cada sitio. Los microhábitats más utilizados fueron la esponja Aplysina fulva y el alga Sargassum sp. No hubo diferencias significativas ni en temperatura ni en salinidad. Las tendencias ambientales no pudieron explicar la variación de la densidad de caballitos de mar en las tres playas. La población no mostró estacionalidad y no disminuyó más.

Published
2018
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4. Formation of distinctive structures of GaN by inductively-coupled-plasma and reactive ion etching under optimized chemical etching conditions

Author

N. Okada, K. Nojima, N. Ishibashi, K. Nagatoshi, N. Itagaki, R. Inomoto, S. Motoyama, T. Kobayashi, and K. Tadatomo

Subjects
Physics, QC1-999
Abstract

We focused on inductively coupled plasma and reactive ion etching (ICP–RIE) for etching GaN and tried to fabricate distinctive GaN structures under optimized chemical etching conditions. To determine the optimum chemical etching conditions, the flow rates of Ar and Cl2, ICP power, and chamber pressure were varied in the etching of c-plane GaN layers with stripe patterns. It was determined that the combination of Ar and Cl2 flow rates of 100 sccm, chamber pressure of 7 Pa, and ICP power of 800 W resulted in the most enhanced reaction, yielding distinctive GaN structures such as pillars with inverted mesa structures for c-plane GaN and a semipolar GaN layer with asymmetric inclined sidewalls. The selectivity and etching rate were also investigated.

Published
2017
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5. Systematic study on the dependence of the warm-start quantum approximate optimization algorithm on approximate solutions

Author

Ken N. Okada, Hirofumi Nishi, Taichi Kosugi, and Yu-ichiro Matsushita

Subjects
Medicine, Science
Abstract

Abstract Quantum approximate optimization algorithm (QAOA) is a promising hybrid quantum-classical algorithm to solve combinatorial optimization problems in the era of noisy intermediate-scale quantum computers. Recently it has been revealed that warm-start approaches can improve the performance of QAOA, where approximate solutions are obtained by classical algorithms in advance and incorporated into the initial state and/or unitary ansatz. In this work, we study in detail how the accuracy of approximate solutions affects the performance of the warm-start QAOA (WS-QAOA). We numerically find that in typical MAX-CUT problems, WS-QAOA achieves higher fidelity (probability that exact solutions are observed) and approximation ratio than QAOA as the Hamming distance of approximate solutions to the exact ones becomes smaller. We reveal that this could be quantitatively attributed to the initial state of the ansatz. We also solve MAX-CUT problems by WS-QAOA with approximate solutions obtained via QAOA, having higher fidelity and approximation ratio than QAOA especially when the circuit is relatively shallow. We believe that our study may deepen understanding of the performance of WS-QAOA and also provide a guide as to the necessary quality of approximate solutions.

Published
2024
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6. Classically optimized variational quantum eigensolver with applications to topological phases

Author

Ken N. Okada, Keita Osaki, Kosuke Mitarai, and Keisuke Fujii

Subjects
Physics, QC1-999
Abstract

The variational quantum eigensolver (VQE) is regarded as a promising candidate of hybrid quantum-classical algorithms for near-term quantum computers. Meanwhile, VQE is confronted with a challenge that statistical error associated with measurement as well as systematic error could significantly hamper the optimization. To circumvent this issue, we propose the classically optimized VQE (CO-VQE), where the whole process of optimization is efficiently conducted on a classical computer. The efficacy of the method is guaranteed by the observation that quantum circuits with up to logarithmic depth are classically tractable via simulations of local subsystems with up to quasipolynomial cost (polynomial for constant depth). In CO-VQE, we only use quantum computers to measure nonlocal quantities after the parameters are optimized. As a proof of concept, we present numerical experiments on quantum spin models with topological phases. After the optimization, we identify the topological phases by nonlocal order parameters as well as unsupervised machine learning on inner products between quantum states. The proposed method maximizes the advantage of using quantum computers while avoiding strenuous optimization on noisy quantum devices. In addition, our paper indicates that clustering technique combined with the fidelity measured on quantum computers could be useful for phase classification in condensed-matter physics.

Published
2023
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7. Overview of the Medium and High Frequency Telescopes of the LiteBIRD Satellite Mission

Author

L. Montier, B. Mot, P. de Bernardis, B. Maffei, G. Pisano, F. Columbro, J. E. Gudmundsson, S. Henrot-Versillé, L. Lamagna, J. Montgomery, T. Prouvé, M. Russell, G. Savini, S. Stever, K. L. Thompson, M. Tsujimoto, C. Tucker, B. Westbrook, P. A.R. Ade, A. Adler, E. Allys, K. Arnold, D. Auguste, J. Aumont, R. Aurlien, J. Austermann, C. Baccigalupi, A. J. Banda, R. Banerji, R. B. Barreiro, S. Basak, J. Beall, D. Beck, S. Beckman, J. Bermejo, M. Bersanelli, J. Bonis, J. Borrill, F. Boulanger, S. Bounissou, M. Brilenkov, M. Brown, M. Bucher, E. Calabrese, P. Campeti, A. Carones, F. J. Casas, A. Challinor, V. Chan, K. Cheung, Y. Chinone, J. F. Cliché, L. Colombo, J. Cubas, A. Cukierman, D. Curtis, G. D’Alessandro, N. Dachlythra, M. De Petris, C. Dickinson, P. Diego-Palazuelos, M. Dobbs, T. Dotani, L. Duband, S. Duff, J. M. Duval, K. Ebisawa, T. Elleflot, H. K. Eriksen, J. Errard, T. Essinger-Hileman, F. Finelli, R. Flauger, C. Franceschet, U. Fuskeland, M. Galloway, K. Ganga, J. R. Gao, R. Genova-Santos, M. Gerbino, M. Gervasi, T. Ghigna, E. Gjerløw, M. L. Gradziel, J. Grain, F. Grupp, A. Gruppuso, T. de Haan, N. W. Halverson, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, D. Herman, D. Herranz, C. A. Hill, G. Hilton, Y. Hirota, E. Hivon, R. A. Hlozek, Y. Hoshino, E. de la Hoz, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, K. Ishimura, H. Ishino, G. Jaehnig, T. Kaga, S. Kashima, N. Katayama, A. Kato, T. Kawasaki, R. Keskitalo, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, I. Kreykenbohm, C. L. Kuo, A. Kushino, J. V. Lanen, M. Lattanzi, A.T. Lee, C. Leloup, F. Levrier, E. Linder, T. Louis, G. Luzzi, T. Maciaszek, D. Maino, M. Maki, S. Mandelli, E. Martinez-Gonzalez, S. Masi, T. Matsumura, A. Mennella, M. Migliaccio, Y. Minami, K. Mitsuda, G. Morgante, Y. Murata, J. A. Murphy, M. Nagai, Y. Nagano, T. Nagasaki, R. Nagata, S. Nakamura, T. Namikawa, P. Natoli, S. Nerval, T. Nishibori, H. Nishino, C. O’Sullivan, H. Ogawa, S. Oguri, H. Ohsaki, I. S. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Patanchon, J. Peloton, F. Piacentini, G. Polenta, D. Poletti, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Reinecke, M. Remazeilles, A. Ritacco, G. Roudil, J. A. Rubino-Martin, H. Sakurai, Y. Sakurai, M. Sandri, M. Sasaki, D. Scott, J. Seibert, Y. Sekimoto, B. Sherwin, K. Shinozaki, M. Shiraishi, P. J. Shirron, G. Signorelli, G. Smecher, R. Stompor, H. Sugai, S. Sugiyama, A. Suzuki, J. Suzuki, T. L. Svalheim, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takase, Y. Takeda, A. Tartari, E. Taylor, Y. Terao, H. Thommesen, B. Thorne, T. Toda, M. Tomasi, M. Tominaga, N. Trappe, M. Tristram, M. Tsuji, J. Ullom, G. Vermeulen, P. Vielva, F. Villa, M. Vissers, N. Vittorio, I. Wehus, J. Weller, J. Wilms, B. Winter, E. J. Wollack, N. Y. Yamasaki, T. Yoshida, J. Yumoto, M. Zannoni, and A. Zonca

Subjects
Instrumentation And Photography, Astrophysics
Abstract

LiteBIRD is a JAXA-led Strategic Large-Class mission designed to search for the existence of the primordial gravitational waves produced during the inflationary phase of the Universe, through the measurements of their imprint onto the polarization of the cosmic microwave background (CMB). These measurements, requiring unprecedented sensitivity, will be performed over the full sky, at large angular scales, and over 15 frequency bands from 34 GHz to 448 GHz. The LiteBIRD instruments consist of three telescopes, namely the Low-, Medium- and High-Frequency Telescope (respectively LFT, MFT and HFT). We present in this paper an overview of the design of the Medium-Frequency Telescope (89–224 GHz) and the High-Frequency Telescope (166–448 GHz), the so-called MHFT, under European responsibility, which are two cryogenic refractive telescopes cooled down to 5 K. They include a continuous rotating half-wave plate as the first optical element, two high-density polyethylene (HDPE) lenses and more than three thousand transition-edge sensor (TES) detectors cooled to 100 mK. We provide an overview of the concept design and the remaining specific challenges that we have to face in order to achieve the scientific goals of LiteBIRD.

Published
2020
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11. Optical Characterization of OMT-Coupled TES Bolometers for LiteBIRD

Author

J. Hubmayr, P. A. R. Ade, A. Adler, E. Allys, D. Alonso, K. Arnold, D. Auguste, J. Aumont, R. Aurlien, J. E. Austermann, S. Azzoni, C. Baccigalupi, A. J. Banday, R. Banerji, R. B. Barreiro, N. Bartolo, S. Basak, E. Battistelli, L. Bautista, J. A. Beall, D. Beck, S. Beckman, K. Benabed, J. Bermejo-Ballesteros, M. Bersanelli, J. Bonis, J. Borrill, F. Bouchet, F. Boulanger, S. Bounissou, M. Brilenkov, M. L. Brown, M. Bucher, E. Calabrese, M. Calvo, P. Campeti, A. Carones, F. J. Casas, A. Catalano, A. Challinor, V. Chan, K. Cheung, Y. Chinone, C. Chiocchetta, S. E. Clark, L. Clermont, S. Clesse, J. Cliche, F. Columbro, J. A. Connors, A. Coppolecchia, W. Coulton, J. Cubas, A. Cukierman, D. Curtis, F. Cuttaia, G. D’Alessandro, K. Dachlythra, P. de Bernardis, T. de Haan, E. de la Hoz, M. De Petris, S. Della Torre, J. J. Daz Garca, C. Dickinson, P. Diego-Palazuelos, M. Dobbs, T. Dotani, D. Douillet, E. Doumayrou, L. Duband, A. Ducout, S. M. Duff, J. M. Duval, K. Ebisawa, T. Elleflot, H. K. Eriksen, J. Errard, T. Essinger-Hileman, S. Farrens, F. Finelli, R. Flauger, K. Fleury-Frenette, C. Franceschet, U. Fuskeland, L. Galli, S. Galli, M. Galloway, K. Ganga, J. R. Gao, R. T. Genova-Santos, M. Georges, M. Gerbino, M. Gervasi, T. Ghigna, S. Giardiello, E. Gjerlw, R. Gonzlez Gonzles, M. L. Gradziel, J. Grain, L. Grandsire, F. Grupp, A. Gruppuso, J. E. Gudmundsson, N. W. Halverson, J. Hamilton, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, S. Henrot-Versill, B. Hensley, D. Herman, D. Herranz, G. C. Hilton, E. Hivon, R. A. Hlozek, D. Hoang, A. L. Hornsby, Y. Hoshino, K. Ichiki, T. Iida, T. Ikemoto, H. Imada, K. Ishimura, H. Ishino, G. Jaehnig, M. Jones, T. Kaga, S. Kashima, N. Katayama, A. Kato, T. Kawasaki, R. Keskitalo, C. Kintziger, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, I. Kreykenbohm, C. L. Kuo, A. Kushino, L. Lamagna, J. V. Lanen, G. Laquaniello, M. Lattanzi, A. T. Lee, C. Leloup, F. Levrier, E. Linder, M. J. Link, A. I. Lonappan, T. Louis, G. Luzzi, J. Macias-Perez, T. Maciaszek, B. Maffei, D. Maino, M. Maki, S. Mandelli, M. Maris, B. Marquet, E. Martnez-Gonzlez, F. A. Martire, S. Masi, M. Massa, M. Masuzawa, S. Matarrese, F. T. Matsuda, T. Matsumura, L. Mele, A. Mennella, M. Migliaccio, Y. Minami, K. Mitsuda, A. Moggi, M. Monelli, A. Monfardini, J. Montgomery, L. Montier, G. Morgante, B. Mot, Y. Murata, J. A. Murphy, M. Nagai, Y. Nagano, T. Nagasaki, R. Nagata, S. Nakamura, R. Nakano, T. Namikawa, F. Nati, P. Natoli, S. Nerval, N. Neto Godry Farias, T. Nishibori, H. Nishino, F. Noviello, G. C. O’Neil, C. O’Sullivan, K. Odagiri, H. Ochi, H. Ogawa, S. Oguri, H. Ohsaki, I. S. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Pascual Cisneros, A. Passerini, G. Patanchon, V. Pelgrim, J. Peloton, V. Pettorino, F. Piacentini, M. Piat, G. Piccirilli, F. Pinsard, G. Pisano, J. Plesseria, G. Polenta, D. Poletti, T. Prouv, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Reinecke, C. D. Reintsema, M. Remazeilles, A. Ritacco, P. Rosier, G. Roudil, J. Rubino-Martin, M. Russell, H. Sakurai, Y. Sakurai, M. Sandri, M. Sasaki, G. Savini, D. Scott, J. Seibert, Y. Sekimoto, B. Sherwin, K. Shinozaki, M. Shiraishi, P. Shirron, A. Shitvov, G. Signorelli, G. Smecher, F. Spinella, J. Starck, S. Stever, R. Stompor, R. Sudiwala, S. Sugiyama, R. Sullivan, A. Suzuki, J. Suzuki, T. Suzuki, T. L. Svalheim, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takase, Y. Takeda, A. Tartari, D. Tavagnacco, A. Taylor, E. Taylor, Y. Terao, L. Terenzi, J. Thermeau, H. Thommesen, K. L. Thompson, B. Thorne, T. Toda, M. Tomasi, M. Tominaga, N. Trappe, M. Tristram, M. Tsuji, M. Tsujimoto, C. Tucker, R. Ueki, J. N. Ullom, K. Umemori, L. Vacher, J. Van Lanen, G. Vermeulen, P. Vielva, F. Villa, M. R. Vissers, N. Vittorio, B. Wandelt, W. Wang, I. K. Wehus, J. Weller, B. Westbrook, G. Weymann-Despres, J. Wilms, B. Winter, E. J. Wollack, N. Y. Yamasaki, T. Yoshida, J. Yumoto, K. Watanuki, A. Zacchei, M. Zannoni, A. Zonca, Hubmayr, J, Ade, P, Adler, A, Allys, E, Alonso, D, Arnold, K, Auguste, D, Aumont, J, Aurlien, R, Austermann, J, Azzoni, S, Baccigalupi, C, Banday, A, Banerji, R, Barreiro, R, Bartolo, N, Basak, S, Battistelli, E, Bautista, L, Beall, J, Beck, D, Beckman, S, Benabed, K, Bermejo-Ballesteros, J, Bersanelli, M, Bonis, J, Borrill, J, Bouchet, F, Boulanger, F, Bounissou, S, Brilenkov, M, Brown, M, Bucher, M, Calabrese, E, Calvo, M, Campeti, P, Carones, A, Casas, F, Catalano, A, Challinor, A, Chan, V, Cheung, K, Chinone, Y, Chiocchetta, C, Clark, S, Clermont, L, Clesse, S, Cliche, J, Columbro, F, Connors, J, Coppolecchia, A, Coulton, W, Cubas, J, Cukierman, A, Curtis, D, Cuttaia, F, D’Alessandro, G, Dachlythra, K, de Bernardis, P, de Haan, T, de la Hoz, E, De Petris, M, Della Torre, S, Daz Garca, J, Dickinson, C, Diego-Palazuelos, P, Dobbs, M, Dotani, T, Douillet, D, Doumayrou, E, Duband, L, Ducout, A, Duff, S, Duval, J, Ebisawa, K, Elleflot, T, Eriksen, H, Errard, J, Essinger-Hileman, T, Farrens, S, Finelli, F, Flauger, R, Fleury-Frenette, K, Franceschet, C, Fuskeland, U, Galli, L, Galli, S, Galloway, M, Ganga, K, Gao, J, Genova-Santos, R, Georges, M, Gerbino, M, Gervasi, M, Ghigna, T, Giardiello, S, Gjerlw, E, Gonzles, R, Gradziel, M, Grain, J, Grandsire, L, Grupp, F, Gruppuso, A, Gudmundsson, J, Halverson, N, Hamilton, J, Hargrave, P, Hasebe, T, Hasegawa, M, Hattori, M, Hazumi, M, Henrot-Versill, S, Hensley, B, Herman, D, Herranz, D, Hilton, G, Hivon, E, Hlozek, R, Hoang, D, Hornsby, A, Hoshino, Y, Ichiki, K, Iida, T, Ikemoto, T, Imada, H, Ishimura, K, Ishino, H, Jaehnig, G, Jones, M, Kaga, T, Kashima, S, Katayama, N, Kato, A, Kawasaki, T, Keskitalo, R, Kintziger, C, Kisner, T, Kobayashi, Y, Kogiso, N, Kogut, A, Kohri, K, Komatsu, E, Komatsu, K, Konishi, K, Krachmalnicoff, N, Kreykenbohm, I, Kuo, C, Kushino, A, Lamagna, L, Lanen, J, Laquaniello, G, Lattanzi, M, Lee, A, Leloup, C, Levrier, F, Linder, E, Link, M, Lonappan, A, Louis, T, Luzzi, G, Macias-Perez, J, Maciaszek, T, Maffei, B, Maino, D, Maki, M, Mandelli, S, Maris, M, Marquet, B, Martnez-Gonzlez, E, Martire, F, Masi, S, Massa, M, Masuzawa, M, Matarrese, S, Matsuda, F, Matsumura, T, Mele, L, Mennella, A, Migliaccio, M, Minami, Y, Mitsuda, K, Moggi, A, Monelli, M, Monfardini, A, Montgomery, J, Montier, L, Morgante, G, Mot, B, Murata, Y, Murphy, J, Nagai, M, Nagano, Y, Nagasaki, T, Nagata, R, Nakamura, S, Nakano, R, Namikawa, T, Nati, F, Natoli, P, Nerval, S, Neto Godry Farias, N, Nishibori, T, Nishino, H, Noviello, F, O’Neil, G, O’Sullivan, C, Odagiri, K, Ochi, H, Ogawa, H, Oguri, S, Ohsaki, H, Ohta, I, Okada, N, Pagano, L, Paiella, A, Paoletti, D, Pascual Cisneros, G, Passerini, A, Patanchon, G, Pelgrim, V, Peloton, J, Pettorino, V, Piacentini, F, Piat, M, Piccirilli, G, Pinsard, F, Pisano, G, Plesseria, J, Polenta, G, Poletti, D, Prouv, T, Puglisi, G, Rambaud, D, Raum, C, Realini, S, Reinecke, M, Reintsema, C, Remazeilles, M, Ritacco, A, Rosier, P, Roudil, G, Rubino-Martin, J, Russell, M, Sakurai, H, Sakurai, Y, Sandri, M, Sasaki, M, Savini, G, Scott, D, Seibert, J, Sekimoto, Y, Sherwin, B, Shinozaki, K, Shiraishi, M, Shirron, P, Shitvov, A, Signorelli, G, Smecher, G, Spinella, F, Starck, J, Stever, S, Stompor, R, Sudiwala, R, Sugiyama, S, Sullivan, R, Suzuki, A, Suzuki, J, Suzuki, T, Svalheim, T, Switzer, E, Takaku, R, Takakura, H, Takakura, S, Takase, Y, Takeda, Y, Tartari, A, Tavagnacco, D, Taylor, A, Taylor, E, Terao, Y, Terenzi, L, Thermeau, J, Thommesen, H, Thompson, K, Thorne, B, Toda, T, Tomasi, M, Tominaga, M, Trappe, N, Tristram, M, Tsuji, M, Tsujimoto, M, Tucker, C, Ueki, R, Ullom, J, Umemori, K, Vacher, L, Van Lanen, J, Vermeulen, G, Vielva, P, Villa, F, Vissers, M, Vittorio, N, Wandelt, B, Wang, W, Wehus, I, Weller, J, Westbrook, B, Weymann-Despres, G, Wilms, J, Winter, B, Wollack, E, Yamasaki, N, Yoshida, T, Yumoto, J, Watanuki, K, Zacchei, A, Zannoni, M, Zonca, A, and National Aeronautics and Space Administration (US)

Subjects
CMB, TES, OMT, Low temperature detector, Bolometer, FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, General Materials Science, Condensed Matter Physics, CMB, TES, OMT, Low temperature detector, Bolometer, Atomic and Molecular Physics, and Optics
Abstract

et al., Feedhorn- and orthomode transducer- (OMT) coupled transition edge sensor (TES) bolometers have been designed and micro-fabricated to meet the optical specifications of the LiteBIRD high frequency telescope (HFT) focal plane. We discuss the design and optical characterization of two LiteBIRD HFT detector types: dual-polarization, dual-frequency-band pixels with 195/280 GHz and 235/337 GHz band centers. Results show well-matched passbands between orthogonal polarization channels and frequency centers within 3% of the design values. The optical efficiency of each frequency channel is conservatively reported to be within the range 0.64−0.72, determined from the response to a cryogenic, temperature-controlled thermal source. These values are in good agreement with expectations and either exceed or are within 10% of the values used in the LiteBIRD sensitivity forecast. Lastly, we report a measurement of loss in Nb/SiNx/Nb microstrip at 100 mK and over the frequency range 200–350 GHz, which is comparable to values previously reported in the literature., This work is supported by NASA under grant no. 80NSSC18K0132.

Published
2022

15. Updated design of the CMB polarization experiment satellite LiteBIRD

Author

H. Sugai, P. A. R. Ade, Y. Akiba, D. Alonso, K. Arnold, J. Aumont, J. Austermann, C. Baccigalupi, A. J. Banday, R. Banerji, R. B. Barreiro, S. Basak, J. Beall, S. Beckman, M. Bersanelli, J. Borrill, F. Boulanger, M. L. Brown, M. Bucher, A. Buzzelli, E. Calabrese, F. J. Casas, A. Challinor, V. Chan, Y. Chinone, J.-F. Cliche, F. Columbro, A. Cukierman, D. Curtis, P. Danto, P. de Bernardis, T. de Haan, M. De Petris, C. Dickinson, M. Dobbs, T. Dotani, L. Duband, A. Ducout, S. Duff, A. Duivenvoorden, J.-M. Duval, K. Ebisawa, T. Elleflot, H. Enokida, H. K. Eriksen, J. Errard, T. Essinger-Hileman, F. Finelli, R. Flauger, C. Franceschet, U. Fuskeland, K. Ganga, J.-R. Gao, R. Génova-Santos, T. Ghigna, A. Gomez, M. L. Gradziel, J. Grain, F. Grupp, A. Gruppuso, J. E. Gudmundsson, N. W. Halverson, P. Hargrave, T. Hasebe, M. Hasegawa, M. Hattori, M. Hazumi, S. Henrot-Versille, D. Herranz, C. Hill, G. Hilton, Y. Hirota, E. Hivon, R. Hlozek, D.-T. Hoang, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, K. Ishimura, H. Ishino, G. C. Jaehnig, M. Jones, T. Kaga, S. Kashima, Y. Kataoka, N. Katayama, T. Kawasaki, R. Keskitalo, A. Kibayashi, T. Kikuchi, K. Kimura, T. Kisner, Y. Kobayashi, N. Kogiso, A. Kogut, K. Kohri, E. Komatsu, K. Komatsu, K. Konishi, N. Krachmalnicoff, C. L. Kuo, N. Kurinsky, A. Kushino, M. Kuwata-Gonokami, L. Lamagna, M. Lattanzi, A. T. Lee, E. Linder, B. Maffei, D. Maino, M. Maki, A. Mangilli, E. Martínez-González, S. Masi, R. Mathon, T. Matsumura, A. Mennella, M. Migliaccio, Y. Minami, K. Mistuda, D. Molinari, L. Montier, G. Morgante, B. Mot, Y. Murata, J. A. Murphy, M. Nagai, R. Nagata, S. Nakamura, T. Namikawa, P. Natoli, S. Nerval, T. Nishibori, H. Nishino, Y. Nomura, F. Noviello, C. O’Sullivan, H. Ochi, H. Ogawa, H. Ohsaki, I. Ohta, N. Okada, L. Pagano, A. Paiella, D. Paoletti, G. Patanchon, F. Piacentini, G. Pisano, G. Polenta, D. Poletti, T. Prouvé, G. Puglisi, D. Rambaud, C. Raum, S. Realini, M. Remazeilles, G. Roudil, J. A. Rubiño-Martín, M. Russell, H. Sakurai, Y. Sakurai, M. Sandri, G. Savini, D. Scott, Y. Sekimoto, B. D. Sherwin, K. Shinozaki, M. Shiraishi, P. Shirron, G. Signorelli, G. Smecher, P. Spizzi, S. L. Stever, R. Stompor, S. Sugiyama, A. Suzuki, J. Suzuki, E. Switzer, R. Takaku, H. Takakura, S. Takakura, Y. Takeda, A. Taylor, E. Taylor, Y. Terao, K. L. Thompson, B. Thorne, M. Tomasi, H. Tomida, N. Trappe, M. Tristram, M. Tsuji, M. Tsujimoto, C. Tucker, J. Ullom, S. Uozumi, S. Utsunomiya, J. Van Lanen, G. Vermeulen, P. Vielva, F. Villa, M. Vissers, N. Vittorio, F. Voisin, I. Walker, N. Watanabe, I. Wehus, J. Weller, B. Westbrook, B. Winter, E. Wollack, R. Yamamoto, N. Y. Yamasaki, M. Yanagisawa, T. Yoshida, J. Yumoto, M. Zannoni, A. Zonca, Sugai, H, Ade, P, Akiba, Y, Alonso, D, Arnold, K, Aumont, J, Austermann, J, Baccigalupi, C, Banday, A, Banerji, R, Barreiro, R, Basak, S, Beall, J, Beckman, S, Bersanelli, M, Borrill, J, Boulanger, F, Brown, M, Bucher, M, Buzzelli, A, Calabrese, E, Casas, F, Challinor, A, Chan, V, Chinone, Y, Cliche, J, Columbro, F, Cukierman, A, Curtis, D, Danto, P, de Bernardis, P, de Haan, T, De Petris, M, Dickinson, C, Dobbs, M, Dotani, T, Duband, L, Ducout, A, Duff, S, Duivenvoorden, A, Duval, J, Ebisawa, K, Elleflot, T, Enokida, H, Eriksen, H, Errard, J, Essinger-Hileman, T, Finelli, F, Flauger, R, Franceschet, C, Fuskeland, U, Ganga, K, Gao, J, Génova-Santos, R, Ghigna, T, Gomez, A, Gradziel, M, Grain, J, Grupp, F, Gruppuso, A, Gudmundsson, J, Halverson, N, Hargrave, P, Hasebe, T, Hasegawa, M, Hattori, M, Hazumi, M, Henrot-Versille, S, Herranz, D, Hill, C, Hilton, G, Hirota, Y, Hivon, E, Hlozek, R, Hoang, D, Hubmayr, J, Ichiki, K, Iida, T, Imada, H, Ishimura, K, Ishino, H, Jaehnig, G, Jones, M, Kaga, T, Kashima, S, Kataoka, Y, Katayama, N, Kawasaki, T, Keskitalo, R, Kibayashi, A, Kikuchi, T, Kimura, K, Kisner, T, Kobayashi, Y, Kogiso, N, Kogut, A, Kohri, K, Komatsu, E, Komatsu, K, Konishi, K, Krachmalnicoff, N, Kuo, C, Kurinsky, N, Kushino, A, Kuwata-Gonokami, M, Lamagna, L, Lattanzi, M, Lee, A, Linder, E, Maffei, B, Maino, D, Maki, M, Mangilli, A, Martínez-González, E, Masi, S, Mathon, R, Matsumura, T, Mennella, A, Migliaccio, M, Minami, Y, Mistuda, K, Molinari, D, Montier, L, Morgante, G, Mot, B, Murata, Y, Murphy, J, Nagai, M, Nagata, R, Nakamura, S, Namikawa, T, Natoli, P, Nerval, S, Nishibori, T, Nishino, H, Nomura, Y, Noviello, F, O’Sullivan, C, Ochi, H, Ogawa, H, Ohsaki, H, Ohta, I, Okada, N, Pagano, L, Paiella, A, Paoletti, D, Patanchon, G, Piacentini, F, Pisano, G, Polenta, G, Poletti, D, Prouvé, T, Puglisi, G, Rambaud, D, Raum, C, Realini, S, Remazeilles, M, Roudil, G, Rubiño-Martín, J, Russell, M, Sakurai, H, Sakurai, Y, Sandri, M, Savini, G, Scott, D, Sekimoto, Y, Sherwin, B, Shinozaki, K, Shiraishi, M, Shirron, P, Signorelli, G, Smecher, G, Spizzi, P, Stever, S, Stompor, R, Sugiyama, S, Suzuki, A, Suzuki, J, Switzer, E, Takaku, R, Takakura, H, Takakura, S, Takeda, Y, Taylor, A, Taylor, E, Terao, Y, Thompson, K, Thorne, B, Tomasi, M, Tomida, H, Trappe, N, Tristram, M, Tsuji, M, Tsujimoto, M, Tucker, C, Ullom, J, Uozumi, S, Utsunomiya, S, Van Lanen, J, Vermeulen, G, Vielva, P, Villa, F, Vissers, M, Vittorio, N, Voisin, F, Walker, I, Watanabe, N, Wehus, I, Weller, J, Westbrook, B, Winter, B, Wollack, E, Yamamoto, R, Yamasaki, N, Yanagisawa, M, Yoshida, T, Yumoto, J, Zannoni, M, Zonca, A, World Premier International Research Center (Japan), Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Agenzia Spaziale Italiana, Istituto Nazionale di Fisica Nucleare, Centre National D'Etudes Spatiales (France), Centre National de la Recherche Scientifique (France), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), European Space Agency, Canadian Space Agency, National Aeronautics and Space Administration (US), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Hélium : du fondamental aux applications (NEEL - HELFA), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Sugai, H. [0000-0001-6501-3871], and Apollo - University of Cambridge Repository

Subjects
Passive cooling, Cosmic Microwave Background, Cosmology, Polarimetry, Instrumentation, Inflation, Cosmic microwave background, cosmic background radiation: polarization, 7. Clean energy, 01 natural sciences, Polarization, General Materials Science, 010303 astronomy & astrophysics, media_common, Physics, Settore FIS/01, Settore FIS/05, Astrophysics::Instrumentation and Methods for Astrophysics, suppression, Condensed Matter Physics, Polarization (waves), Atomic and Molecular Physics, and Optics, Infation, adiabatic, Astrophysics - Instrumentation and Methods for Astrophysics, signature, Astrophysics and Astronomy, media_common.quotation_subject, Lagrangian point, Inflation, Primordial gravitational wave, Satellite, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Noise (electronics), Article, NO, FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, noise: thermal, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010308 nuclear & particles physics, Gravitational wave, PE9_14, beam: width, gravitational radiation: primordial, Astronomy, 13. Climate action, Sky, spectral, galaxy, astro-ph.IM
Abstract

H. Sugai, et al., Recent developments of transition-edge sensors (TESs), based on extensive experience in ground-based experiments, have been making the sensor techniques mature enough for their application on future satellite cosmic microwave background (CMB) polarization experiments. LiteBIRD is in the most advanced phase among such future satellites, targeting its launch in Japanese Fiscal Year 2027 (2027FY) with JAXA’s H3 rocket. It will accommodate more than 4000 TESs in focal planes of reflective low-frequency and refractive medium-and-high-frequency telescopes in order to detect a signature imprinted on the CMB by the primordial gravitational waves predicted in cosmic inflation. The total wide frequency coverage between 34 and 448 GHz enables us to extract such weak spiral polarization patterns through the precise subtraction of our Galaxy’s foreground emission by using spectral differences among CMB and foreground signals. Telescopes are cooled down to 5 K for suppressing thermal noise and contain polarization modulators with transmissive half-wave plates at individual apertures for separating sky polarization signals from artificial polarization and for mitigating from instrumental 1/f noise. Passive cooling by using V-grooves supports active cooling with mechanical coolers as well as adiabatic demagnetization refrigerators. Sky observations from the second Sun–Earth Lagrangian point, L2, are planned for 3 years. An international collaboration between Japan, the USA, Canada, and Europe is sharing various roles. In May 2019, the Institute of Space and Astronautical Science, JAXA, selected LiteBIRD as the strategic large mission No. 2., This work was supported by World Premier International Research Center Initiative (WPI), MEXT, Japan, by JSPS Core-to-Core Program, A. Advanced Research Networks, and by JSPS KAKENHI Grant Numbers JP15H05891, JP17H01115, and JP17H01125. The Italian contribution to the LiteBIRD phase A is supported by the Italian Space Agency (ASI Grant No. 2016-24- H.1-2018) and the National Institute for Nuclear Physics (INFN). The French contribution to the LiteBIRD phase A is supported by the Centre National d’Etudes Spatiale (CNES), by the Centre National de la Recherche Scientifque (CNRS), and by the Commissariat à l’Energie Atomique (CEA). A Concurrent Design Facility study focused on the MHFT and Sub-Kelvin coolers has been led by the European Space Agency (ESA). The Canadian contribution to LiteBIRD is supported by the Canadian Space Agency. The US contribution is supported by NASA Grant no. 80NSSC18K0132

Published
2020
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17. Leak grading and percutaneous transanastomotic drainage for the treatment of cervical anastomotic leakage after esophagectomy

Author

Shuhei Mayanagi, Hiroyuki Daiko, Takeo Fujita, Masato Nagino, Hisashi Fujiwara, Jun Kanamori, and N. Okada

Subjects
medicine.medical_specialty, Leak, Percutaneous, business.industry, General surgery, medicine.medical_treatment, Gastroenterology, General Medicine, 030230 surgery, Surgery, 03 medical and health sciences, 0302 clinical medicine, Anastomotic leakage, Esophagectomy, 030220 oncology & carcinogenesis, Medicine, Drainage, business, Grading (tumors)
Published
2017

18. Magnetoelectric effect in band insulator-ferromagnet heterostructures

Author

Ken N. Okada, Yukitoshi Motome, and Yasuyuki Kato

Subjects
Magnetoelectric effect, FOS: Physical sciences, 02 engineering and technology, 01 natural sciences, Magnetization, Condensed Matter::Materials Science, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), 0103 physical sciences, 010306 general physics, Physics, Condensed Matter - Materials Science, Spintronics, Magnetic moment, Condensed matter physics, Condensed Matter - Mesoscale and Nanoscale Physics, Scattering, business.industry, Condensed Matter::Other, Materials Science (cond-mat.mtrl-sci), Heterojunction, 021001 nanoscience & nanotechnology, Semiconductor, Ferromagnetism, Condensed Matter::Strongly Correlated Electrons, 0210 nano-technology, business
Abstract

We theoretically study magnetoelectric effects in a heterostructure of a generic band insulator and a ferromagnet. In contrast to the kinetic magnetoelectric effect in metals, referred to as the Edelstein effect or the inverse spin galvanic effect, our mechanism relies on virtual interband transitions between the valence and conduction bands and therefore immune to disorder or impurity scattering. By calculating electric field-induced magnetization by the linear response theory, we reveal that the magnetoelectric effect shows up without specific parameter choices. The magnetoelectric effect qualitatively varies by changing the direction of the magnetic moment in the ferromagnet: the response is diagonal for the out-of-plane moment, whereas it is off-diagonal for the inplane moment. We also find out that in optical frequencies, the magnetoelectric signal can be drastically enhanced via interband resonant excitations. Finally, we estimate the magnitude of the magnetoelectric effect for a hybrid halide perovskite semiconductor as an example of the band insulator and compare it with other magnetoelectric materials. We underscore that our mechanism is quite general and widely expectable, only requiring the Rashba spin-orbit coupling and exchange coupling. Our result could potentially offer a promising method of Joule heating-free electric manipulation of magnetic moments in spintronic devices., 11 pages, 8 figures

Published
2019

19. Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation

Author

Y, Zamami, Y, Kouno, T, Niimura, M, Chuma, T, Imai, M, Mitsui, T, Koyama, M, Kayano, N, Okada, H, Hamano, M, Goda, M, Imanishi, K, Takechi, Y, Horinouchi, Y, Kondo, H, Yanagawa, Y, Kitamura, T, Sendo, Y, Ujike, and K, Ishizawa

Subjects
Adult, Aged, 80 and over, Male, Delirium, Middle Aged, Calcium Channel Blockers, Respiration, Artificial, Intensive Care Units, Nicardipine, Risk Factors, Hypertension, Multivariate Analysis, Prevalence, Humans, Female, Antihypertensive Agents, Aged, Retrospective Studies
Abstract

A history of hypertension is a known risk factor for delirium in patients in intensive care units, but the effect of antihypertensive agents on delirium development is unclear. Nicardipine, a calcium channel blocker, is widely used in ICU as a treatment agent for hypertensive emergency. This study investigated the relationship between the administration of nicardipine hydrochloride and delirium development in patients under mechanical ventilation. We conducted a medical chart review of 103 patients, who were divided into two groups according to the use of nicardipine hydrochloride. The prevalence of delirium was compared with respect to factors such as age, sex, laboratory data, and medical history, by multivariate analysis. 21 patients (20.4 %) were treated with nicardipine hydrochloride in 103 patients. The treatment and non-treatment groups differed significantly in age (72 vs. 65 years) and history of high blood pressure (57% vs. 11%). Multivariate analysis revealed that patients in the treatment group developed delirium significantly less often than those in the non-treatment group (19% vs. 48%). These results suggested that treatment of high blood pressure with nicardipine hydrochloride is a possible method for preventing the development of delirium.

Published
2018

20. Terahertz spectroscopy on Faraday and Kerr rotations in a quantum anomalous Hall state

Author

Atsushi Tsukazaki, Yoshinori Tokura, Ken N. Okada, Masataka Mogi, Naoki Ogawa, Kei S. Takahashi, Youtarou Takahashi, Masashi Kawasaki, and Ryutaro Yoshimi

Subjects
Terahertz radiation, Science, Magnetoelectric effect, General Physics and Astronomy, Physics::Optics, 02 engineering and technology, 01 natural sciences, Article, General Biochemistry, Genetics and Molecular Biology, law.invention, Condensed Matter::Materials Science, law, Quantum mechanics, 0103 physical sciences, 010306 general physics, Faraday cage, Quantum, Physics, Multidisciplinary, Condensed matter physics, Condensed Matter::Other, Fine-structure constant, General Chemistry, 021001 nanoscience & nanotechnology, Magnetic susceptibility, Terahertz spectroscopy and technology, Topological insulator, 0210 nano-technology
Abstract

Electrodynamic responses from three-dimensional topological insulators are characterized by the universal magnetoelectric term constituent of the Lagrangian formalism. The quantized magnetoelectric coupling, which is generally referred to as topological magnetoelectric effect, has been predicted to induce exotic phenomena including the universal low-energy magneto-optical effects. Here we report the experimental indication of the topological magnetoelectric effect, which is exemplified by magneto-optical Faraday and Kerr rotations in the quantum anomalous Hall states of magnetic topological insulator surfaces by terahertz magneto-optics. The universal relation composed of the observed Faraday and Kerr rotation angles but not of any material parameters (for example, dielectric constant and magnetic susceptibility) well exhibits the trajectory towards the fine structure constant in the quantized limit., Quantized magnetoelectric coupling, which induces exotic magneto-optical phenomena, awaits to be evidenced in topological insulators. Here, Okada et al. demonstrate Faraday and Kerr rotations of magnetic topological insulator surfaces in quantum anomalous Hall states by terahertz magneto-optics, indicating topological magnetoelectric effect.

Published
2016

21. Multiple-$Q$ magnetic orders in Rashba-Dresselhaus metals

Author

Yasuyuki Kato, Ken N. Okada, and Yukitoshi Motome

Subjects
Physics, Coupling, Condensed Matter::Quantum Gases, Condensed Matter - Materials Science, Strongly Correlated Electrons (cond-mat.str-el), Magnetic moment, Condensed matter physics, Skyrmion, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Heterojunction, Fermi surface, 02 engineering and technology, Electron, 021001 nanoscience & nanotechnology, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, 01 natural sciences, Magnetic field, Condensed Matter - Strongly Correlated Electrons, Lattice (order), 0103 physical sciences, Condensed Matter::Strongly Correlated Electrons, 010306 general physics, 0210 nano-technology
Abstract

We study magnetic textures realized in noncentrosymmetric Kondo lattice models, in which localized magnetic moments weakly interact with itinerant electrons subject to Rashba and Dresselhaus spin-orbit couplings. By virtue of state-of-the-art numerical simulations as well as variational calculations, we uncover versatile multiple-$Q$ orderings under zero magnetic field, which are found to originate in the instabilities of the Fermi surface whose spin degeneracy is lifted by the spin-orbit couplings. In the case with equally-strong Rashba and Dresselhaus spin-orbit couplings, which is known to realize a persistent spin helix in semiconductor quantum wells, we discover a sextuple-$Q$ magnetic ordering with a checkerboard-like spatial pattern of the spin scalar chirality. In the presence of either Rashba or Dresselhaus spin-orbit coupling, we find out another multiple-$Q$ ordering, which is distinct from Skyrmion crystals discussed under the same symmetry. Our results indicate that the cooperation of the spin-charge and spin-orbit couplings brings about richer magnetic textures than those studied within effective spin models. The situations would be experimentally realized, e.g., in noncentrosymmetric heavy-fermion compounds and heterostructures of spin-orbit coupled metals and magnetic insulators.

Published
2018

23. P4833Risk predictors of supraventricular tachycardia and bradycardia necessitating therapy in patients with unexplained syncope receiving implantable loop recorder

Author

Youichi Kobayashi, Yuta Chiba, Yumi Munetsugu, Yuya Nakamura, Shirou Kawasaki, Yoshimi Onishi, Norikazu Watanabe, Toshihiko Gokan, N Okada, Yoshino Minoura, H Ito, Tarou Adachi, Tatsuya Onuki, Mitsuharu Kawamura, and Makoto Shoji

Subjects
Bradycardia, medicine.medical_specialty, biology, business.industry, Syncope (genus), biology.organism_classification, medicine.disease, Internal medicine, medicine, Cardiology, Implantable loop recorder, In patient, Supraventricular tachycardia, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Published
2018

24. FRI0131 Potential factors associated with long-term continuation of etanercept

Author

Satoshi Soen, N. Okada, M. Kamiya, and Hiraku Kikuchi

Subjects
medicine.medical_specialty, Combination therapy, business.industry, Retrospective cohort study, medicine.disease, Confidence interval, Etanercept, Discontinuation, Internal medicine, Rheumatoid arthritis, medicine, Rheumatoid factor, Adverse effect, business, medicine.drug
Abstract

Background With the advent of biologic agents, it has become possible to prevent progression of symptoms and joint destruction in rheumatoid arthritis (RA). However, less than half of patients achieve remission. The patient subgroup that benefits from a specific biologic agent remains unclear. Etanercept has been repeatedly reported to have a high long-term continuation rate, and can also be tapered once the therapeutic goal has been achieved. Identification of a patient subgroup that benefits from long-term use of etanercept would not only benefit the patients but would also reduce healthcare costs. Objectives The purpose of this study was to evaluate the characteristics of patients who benefited from long-term use of etanercept and patients who discontinued the drug due to loss of efficacy using our hospital records, and evaluated factors that may predict the difference in efficacy. Methods We compared RA patients who continued etanercept treatment for at least 3 years, without interruption for 3 months or longer for reasons other than remission, including patients who switched from other biologics (continuation group), and patients who discontinued treatment within 3 years of treatment initiation due to loss of efficacy (discontinuation group). All patients were treated at our hospital before October 31, 2017. Multiple regression analysis was used to determine factors that may predict long-term etanercept efficacy, using 10 patient background characteristics, including age at initiation of etanercept and DAS28ESR, as explanatory variables. Results At the time of evaluation, the 3 year continuation rate of etanercept by the Kaplan-Meier method was 49.7%. Reasons for discontinuation included adverse events (33.3%), loss of efficacy (50%), and patient preference (17.3%). The continuation group comprised 87 cases, including 5 cases where etanercept was discontinued due to remission. Initial dose was 50 mg, and relative dose intensity was 0.78 (95% confidence interval 0.66–0.89). The discontinuation group included 51 cases. Regarding patient characteristics at the time of etanercept initiation, age (continuation group 60.1 vs. discontinuation group 66.7, p=0.019), number of previously used biologics (continuation group 1.24 vs. discontinuation group 1.45, p=0.016), and disease duration (continuation group 110.2 months vs. discontinuation group 74.2 months, p=0.035) were statistically significant with α=0.05, suggesting potential utility in predicting long-term response. In contrast, combination therapy with methotrexate (p=0.259), rheumatoid factor, or anti-cyclic citrullinated peptide antibody positivity (p=0.086), and DAS28ESR (p=0.056) were not statistically significant. Conclusions Although this was a retrospective study, the results showed that young RA patients who have previously used few biologics, with long disease duration, may be more likely to benefit long-term from etanercept without loss of efficacy. Disclosure of Interest None declared

Published
2018

25. The LiteBIRD Satellite Mission: Sub-Kelvin Instrument

Author

A. Suzuki, P. A. R. Ade, Y. Akiba, D. Alonso, K. Arnold, J. Aumont, C. Baccigalupi, D. Barron, S. Basak, S. Beckman, J. Borrill, F. Boulanger, M. Bucher, E. Calabrese, Y. Chinone, S. Cho, B. Crill, A. Cukierman, D. W. Curtis, T. de Haan, M. Dobbs, A. Dominjon, T. Dotani, L. Duband, A. Ducout, J. Dunkley, J. M. Duval, T. Elleflot, H. K. Eriksen, J. Errard, J. Fischer, T. Fujino, T. Funaki, U. Fuskeland, K. Ganga, N. Goeckner-Wald, J. Grain, N. W. Halverson, T. Hamada, T. Hasebe, M. Hasegawa, K. Hattori, M. Hattori, L. Hayes, M. Hazumi, N. Hidehira, C. A. Hill, G. Hilton, J. Hubmayr, K. Ichiki, T. Iida, H. Imada, M. Inoue, Y. Inoue, K. D. Irwin, H. Ishino, O. Jeong, H. Kanai, D. Kaneko, S. Kashima, N. Katayama, T. Kawasaki, S. A. Kernasovskiy, R. Keskitalo, A. Kibayashi, Y. Kida, K. Kimura, T. Kisner, K. Kohri, E. Komatsu, K. Komatsu, C. L. Kuo, N. A. Kurinsky, A. Kusaka, A. Lazarian, A. T. Lee, D. Li, E. Linder, B. Maffei, A. Mangilli, M. Maki, T. Matsumura, S. Matsuura, D. Meilhan, S. Mima, Y. Minami, K. Mitsuda, L. Montier, M. Nagai, T. Nagasaki, R. Nagata, M. Nakajima, S. Nakamura, T. Namikawa, M. Naruse, H. Nishino, T. Nitta, T. Noguchi, H. Ogawa, S. Oguri, N. Okada, A. Okamoto, T. Okamura, C. Otani, G. Patanchon, G. Pisano, G. Rebeiz, M. Remazeilles, P. L. Richards, S. Sakai, Y. Sakurai, Y. Sato, N. Sato, M. Sawada, Y. Segawa, Y. Sekimoto, U. Seljak, B. D. Sherwin, T. Shimizu, K. Shinozaki, R. Stompor, H. Sugai, H. Sugita, J. Suzuki, O. Tajima, S. Takada, R. Takaku, S. Takakura, S. Takatori, D. Tanabe, E. Taylor, K. L. Thompson, B. Thorne, T. Tomaru, T. Tomida, N. Tomita, M. Tristram, C. Tucker, P. Turin, M. Tsujimoto, S. Uozumi, S. Utsunomiya, Y. Uzawa, F. Vansyngel, I. K. Wehus, B. Westbrook, M. Willer, N. Whitehorn, Y. Yamada, R. Yamamoto, N. Yamasaki, T. Yamashita, M. Yoshida, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Cosmic microwave background, FOS: Physical sciences, cosmic background radiation: polarization, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Radio spectrum, law.invention, Antenna array, Telescope, Optics, bolometer, Settore FIS/05 - Astronomia e Astrofisica, law, Polarization, 0103 physical sciences, B-mode, Inflation, Satellite, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, activity report, detector: design, Physics, 010308 nuclear & particles physics, business.industry, Gravitational wave, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Astrophysics - Astrophysics of Galaxies, Atomic and Molecular Physics, and Optics, cryogenics, Astrophysics of Galaxies (astro-ph.GA), electronics: readout, interference: quantum, Transition edge sensor, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], business, cosmic background radiation: anisotropy
Abstract

著者人数: 153名（所属. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS): 堂谷, 忠靖; 羽澄, 昌史; 今田, 大皓; 満田, 和久; 坂井, 真一郎; Tomida, T.; 辻本, 匡弘; Yamamoto, R.; 山崎, 典子）, Accepted: 2018-04-30, 資料番号: SA1180210000

Published
2018

26. Concept design of the LiteBIRD satellite for CMB B-mode polarization

Author

A. Cukierman, Makoto Hattori, Alessandro Gruppuso, Y. Kataoka, D. T. Hoang, Kam Arnold, Tucker Elleflot, Benjamin Westbrook, Eric V. Linder, Johannes Hubmayr, Toshiyuki Nishibori, Christopher Raum, T. Kikuchi, Luca Lamagna, S. Takakura, Shingo Kashima, Ryota Takaku, Ken Ganga, N. Katayama, Masahiro Tsujimoto, Yutaro Sekimoto, A. Kibayashi, Hajime Sugai, H. K. Eriksen, Noah Kurinsky, F. Columbro, Gianluca Morgante, Toshiya Namikawa, Yuki Sakurai, B. Mot, E. Martínez-González, H. Nishino, G. Jaehnig, Hiroyuki Ohsaki, Shogo Nakamura, Peter A. R. Ade, L. Montier, T. Kawasaki, Giuseppe Puglisi, Charles A. Hill, H. Takakura, Masaaki Nagai, Anna Murphy, D. W. Curtis, M. Tristram, Adrian T. Lee, J. Grain, S. Realini, H. Ochi, Peter Charles Hargrave, Theodore Kisner, Maresuke Shiraishi, F. Boulanger, Y. Kobayashi, M. Tomasi, G. Signorelli, Y. Hirota, M. Tsuji, Graeme Smecher, F. Piacentini, K. Ebisawa, S. Beckman, Carlo Baccigalupi, E. Hivon, K. Mistuda, Haruyuki Sakurai, Soumen Basak, C. L. Kuo, G. Patanchon, Ingunn Kathrine Wehus, Masashi Hazumi, J. Aumont, Berend Winter, I. S. Ohta, Reijo Keskitalo, Bruno Maffei, Ryo Yamamoto, Marco Bersanelli, Mario Zannoni, P. Natoli, Junji Yumoto, Andrea Zonca, Erminia Calabrese, A. Ducout, Blake D. Sherwin, N. Trappe, U. Fuskeland, Nicoletta Krachmalnicoff, K. L. Thompson, M. A. Dobbs, F. Noviello, Anna Mangilli, Jun-ichi Suzuki, A. Kushino, Tadayasu Dotani, S. Sugiyama, H. Kanai, T. Yoshida, Silvia Masi, G. Polenta, M. Yanagisawa, N. Watanabe, R. Nagata, J. Austermann, Keisuke Shinozaki, Yasunori Terao, Davide Poletti, Cristian Franceschet, Michael L. Brown, Anthony Challinor, M. De Petris, Masaya Hasegawa, Yuto Minami, Noriko Y. Yamasaki, L. Duband, Créidhe O'Sullivan, Yasuhiro Murata, J. R. Gao, B. Thorne, Eiichiro Komatsu, P. de Bernardis, Kazunori Kohri, Hirokazu Ishino, Kuniaki Konishi, A. J. Banday, N. W. Halverson, A. Mennella, Kiyotomo Ichiki, T. Hasebe, Giorgio Savini, Julian Borrill, Yuji Chinone, Mathieu Remazeilles, Giampaolo Pisano, D. Molinari, Radek Stompor, M. Maki, H. Tomida, N. Okada, H. Imada, S. Uozumi, Nozomu Kogiso, R. Banerji, Tomotake Matsumura, Raphael Flauger, T. Ghigna, Josquin Errard, Shin Utsunomiya, M. Bucher, K. Komatsu, Hideo Ogawa, E. Taylor, Kimihiro Kimura, Sophie Henrot-Versille, Nicola Vittorio, Aritoki Suzuki, Realini, S, Patanchon, G, Kataoka, Y, Zonca, A, Zannoni, M, Yumoto, J, Yoshida, T, Yanagisawa, M, Yamasaki, N, Yamamoto, R, Westbrook, B, Wehus, I, Watanabe, N, Vittorio, N, Utsunomiya, S, Uozumi, S, Tsujimoto, M, Tsuji, M, Tristram, M, Trappe, N, Tomida, H, Tomasi, M, Thorne, B, Thompson, K, Terao, Y, Taylor, E, Takakura, S, Takakura, H, Takaku, R, Suzuki, J, Suzuki, A, Sugiyama, S, Sugai, H, Stompor, R, Smecher, G, Signorelli, G, Shiraishi, M, Shinozaki, K, Sherwin, B, Savini, G, Sakurai, Y, Sakurai, H, Remazeilles, M, Raum, C, Puglisi, G, Poletti, D, Polenta, G, Pisano, G, Piacentini, F, Okada, N, Ohsaki, H, Ogawa, H, Ochi, H, O'Sullivan, C, Nishino, H, Nishibori, T, Natoli, P, Namikawa, T, Nakamura, S, Nagata, R, Nagai, M, Murphy, A, Murata, Y, Mot, B, Morgante, G, Montier, L, Molinari, D, Mitsuda, K, Minami, Y, Mennella, A, Matsumura, T, Masi, S, Martinez-Gonzalez, E, Maki, M, Maffei, B, Linder, E, Lee, A, Lamagna, L, Kushino, A, Kurinsky, N, Kuo, C, Krachmalnicoff, N, Konishi, K, Komatsu, K, Komatsu, E, Kohri, K, Kogiso, N, Kobayashi, Y, Kisner, T, Kimura, K, Kikuchi, T, Kibayashi, A, Keskitalo, R, Kawasaki, T, Katayama, N, Kashima, S, Kanai, H, Arnold, K, Jaehnig, G, Ishino, H, Imada, H, Ichiki, K, Hubmayr, J, Hoang, D, Hivon, E, Hirota, Y, Hill, C, Henrot-Versille, S, Hazumi, M, Hattori, M, Hasegawa, M, Hasebe, T, Hargrave, P, Halverson, N, Gruppuso, A, Grain, J, Ghigna, T, Gao, J, Ganga, K, Fuskeland, U, Franceschet, C, Flauger, R, Errand, J, Eriksen, H, Elleflot, T, Ebisawa, K, Ducout, A, Duband, L, Dotani, T, Dobbs, M, de Petris, M, de Bernardis, P, Curtis, D, Cukierman, A, Columbro, F, Chinone, Y, Challinor, A, Calabrese, E, Bucher, M, Brown, M, Boulanger, F, Borill, J, Bersanelli, M, Beckman, S, Basak, S, Banerji, R, Banday, A, Baccigalupi, C, Austermann, J, Aumont, J, Mangilli, A, Ade, P, Winter, B, Ota, I, Noviello, F, Sekimoto, Y, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and LiteBIRD

Subjects
Cosmic microwave background, Cryogenic telescope, Millimeter-wave polarization, Space program, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering, media_common.quotation_subject, satellite, Lagrangian point, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, frequency: high, law.invention, NO, Telescope, cosmic background radiation: B-mode, FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, law, 0103 physical sciences, Electronic, Cosmology, Cosmic Microwave Background, CMB, Polarimetry, Inflation, Instrumentation, structure, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Optical and Magnetic Materials, 010306 general physics, Astrophysics::Galaxy Astrophysics, media_common, Physics, polarization, 010308 nuclear & particles physics, Gravitational wave, Settore FIS/05, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Polarization (waves), sensitivity, Superconducting detectors, frequency: low, angular resolution, Sky, cryogenics, Launch vehicle, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

LiteBIRD is a candidate for JAXA’s strategic large mission to observe the cosmic microwave background (CMB) polarization over the full sky at large angular scales. It is planned to be launched in the 2020s with an H3 launch vehicle for three years of observations at a Sun-Earth Lagrangian point (L2). The concept design has been studied by researchers from Japan, U.S., Canada and Europe during the ISAS Phase-A1. Large scale measurements of the CMB B-mode polarization are known as the best probe to detect primordial gravitational waves. The goal of LiteBIRD is to measure the tensor-to-scalar ratio (r) with precision of δr < 0.001. A 3-year full sky survey will be carried out with a low frequency (34 - 161 GHz) telescope (LFT) and a high frequency (89 - 448 GHz) telescope (HFT), which achieve a sensitivity of 2.5 µK-arcmin with an angular resolution of ∼ 30 arcminutes around 100 GHz. The concept design of LiteBIRD system, payload module (PLM), cryo-structure, LFT and verification plan is described in this paper. © 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)

Published
2018

28. AB0253 Tips on selection of biologics for patients with rheumatoid arthritis based on treatment patterns

Author

Satoshi Soen, M. Kamiya, N. Okada, and Hiraku Kikuchi

Subjects
medicine.medical_specialty, business.industry, Abatacept, medicine.disease, Confidence interval, Discontinuation, Etanercept, chemistry.chemical_compound, Tocilizumab, chemistry, Concomitant, Rheumatoid arthritis, Internal medicine, medicine, Physical therapy, Medical history, business, medicine.drug
Abstract

Background The emergence of biologics has led to innovation in the treatment of rheumatoid arthritis (RA). In the clinical setting, biologics are administered with careful consideration of complications and medical history in accordance with the treat-to-target recommendations. However, the progression of joint damage, the costs incurred before finding an effective biologic are serious concerns. It is therefore desirable to use biologics with long-term efficacy and less financial burden from the early stage. Objectives Participants were RA patients treated with one of three biologics having different mechanisms of action who achieved therapy targets with long-term treatment efficacy and consequently achieved either reduction or withdrawal of therapy. Patients9 background characteristics and long-term treatment patterns were evaluated. Methods Between November 2004 and October 2016, 196, 57, and 85 RA patients were treated with etanercept (ETN), tocilizumab (TCZ), and abatacept (ABT), respectively, in first- or second-line therapy. These patients were divided into the continuation group, who underwent therapy with the same agent for ≥3 years without disease flare (DAS28-ESR >3.2) persisting 3 months, and the discontinuation group, who experienced primary failure resulting in discontinuation of the therapy within 3 months. Student9s t test or Mann-Whitney9s U test were used to compare patients9 background characteristics between the two groups for each biologic. Further, log-rank test and Steel-Dwass test, respectively, were used to compare therapy continuation rates and reasons for discontinuation among the three biologics. Finally, relative dose intensity (RDI) was calculated to evaluate the treatment patterns of the individual biologics. Results The Kaplan-Meier method showed that the 3-year continuation rates of therapy with ETN, TCZ, and ABT were 54.2%, 23.8%, and 35.8%, respectively: the continuation rate of ETN was significantly higher than that of the other two agents. The numbers of patients treated with ETN, TCZ, and ABT were respectively 46, 9, and 14 in the continuation group and 16, 12, and 11 in the discontinuation group. The proportion of patients treated with ETN plus concomitant MTX was significantly higher in the continuation group than in the discontinuation group (P=0.0057). No significant differences were found in patients9 background characteristics (disease duration, rheumatoid or anti-cyclic citrullinated peptide positivity, number of biologics previously used, and DAS28-ESR). Mean RDI values (median value, 95% confidence interval) over a 3-year period were as follows: 0.95 (0.92, 0.83–1.06) for 25 mg/week ETN therapy; 0.78 (0.90, 0.66–0.89) for 50 mg/week ETN therapy; 0.84 (0.84, 0.76–0.89) for TCZ therapy; and 0.87 (0.94, 0.79–0.95) for ABT therapy. The cumulative costs for 3 years of the respective treatments were 19,700, 32,200, 27,300, and 39,000 euros (1 euro =115 Japanese yen). After targets were reached, the dose of ETN was maintained at 25 mg/week or reduced from 50 mg/week, while the TCZ and ABT therapies were continued over the long term with a longer dosing interval. Conclusions Treatment with ETN plus concomitant MTX showed high continuation rates, and long-term achievement of therapy targets was maintained at a lower dosage (and thus, lower costs). It is beneficial to choose this method over non-TNF inhibitors. Disclosure of Interest None declared

Published
2017

29. HCM12A Cr-rich oxide layer investigation using 3D atom probe

Author

Hiroshi Uchida, N. Okada, Kenji Kikuchi, Shigeru Saito, and M. Kato

Subjects
Nuclear and High Energy Physics, Materials science, Lead-bismuth eutectic, Metallurgy, Spinel, Analytical chemistry, Oxide, Atom probe, engineering.material, Layer thickness, law.invention, chemistry.chemical_compound, Nuclear Energy and Engineering, chemistry, law, Martensite, engineering, General Materials Science, Magnetite
Abstract

Three-dimensional atom probe techniques were applied to the investigation on the oxide scale in 12Cr ferritic/martensitic steel, HCM12A. A duplex oxide scale was formed in lead bismuth eutectic at 450–500 °C, during 5500 h. Samples were located 500–700 nm away from the boundary between magnetite and Fe–Cr spinel layers, while the total oxide layer thickness is 18 μm. It detected super enrichment of Cr with a size of ten nm roughly, as well as depletion of Fe and enrichment of O at the same site. Surrounding the Cr super enrichment area, enrichment of Si was newly noticed due to the scanned profile of detected atom counts. It is also confirmed that Pb and Bi concentration in the observed spinel region is almost null or less than 0.01atomic%, which is possible detecting lowest limit.

Published
2014

30. Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

Author

Tatsuhiro Shibata, H Taniguchi, Y Arai, Issei Imoto, Kazuyoshi Yanagihara, N Kitagawa, Hitoshi Katai, H Shimizu, Fumie Hosoda, Johji Inazawa, N Okada, M Miyamoto, and Misao Ohki

Subjects
Cancer Research, Receptor, ErbB-2, Gene Dosage, Biology, Mice, Lactoylglutathione lyase, Growth factor receptor, Stomach Neoplasms, Cell Line, Tumor, Gene expression, Genetics, Animals, Humans, Molecular Biology, Comparative Genomic Hybridization, Gene knockdown, Oncogene, Microarray analysis techniques, Gene Amplification, Lactoylglutathione Lyase, NF-kappa B, Genomics, Amplicon, Glutathione, Molecular biology, Transcription Factor AP-1, HEK293 Cells, NIH 3T3 Cells, biology.protein, Chromosomes, Human, Pair 6, Signal Transduction, Glyoxalase system
Abstract

Chromosomal abnormalities are good guideposts when hunting for cancer-related genes. We analyzed copy number alterations of 163 primary gastric cancers using array-based comparative genomic hybridization and simultaneously performed a genome-wide integrated analysis of copy number and gene expression using microarray data for 58 tumors. We showed that chromosome 6p21 amplification frequently occurred secondary to ERBB2 amplification, was associated with poorer prognosis and caused overexpression of half of the genes mapped. A comprehensive small interfering RNA knockdown of 58 genes overexpressed in tumors identified 32 genes that reduced gastric cancer cell growth. Enforced expression of 16 of these genes promoted cell growth in vitro, and six genes showing more than two-fold activity conferred tumor-forming ability in vivo. Among these six candidates, GLO1, encoding a detoxifying enzyme glyoxalase I (GLO1), exhibited the strongest tumor-forming activity. Coexpression of other genes with GLO1 enhanced growth-stimulating activity. A GLO1 inhibitor, S-p-bromobenzyl glutathione cyclopentyl diester, inhibited the growth of two-thirds of 24 gastric cancer cell lines examined. The efficacy was found to be associated with the mRNA expression ratio of GLO1 to GLO2, encoding glyoxalase II (GLO2), another constituent of the glyoxalase system. GLO1 downregulation affected cell growth through inactivating central carbon metabolism and reduced the transcriptional activities of nuclear factor kappa B and activator protein-1. Our study demonstrates that GLO1 is a novel metabolic oncogene of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production and could be a potential therapeutic target in gastric cancer.

Published
2014

33. Beam Pattern Measurements of Millimeter-Wave Kinetic Inductance Detector Camera With Direct Machined Silicon Lens Array

Author

Tom Nitta, Naomasa Nakai, Masakazu Sekine, Kenichi Karatsu, Masumichi Seta, Takashi Noguchi, N. Okada, Yutaro Sekimoto, Masato Naruse, Hiroshi Matsuo, K. Mitsui, and Y. Uzawa

Subjects
Physics, Radiation, Silicon, business.industry, Terahertz radiation, Astrophysics::Instrumentation and Methods for Astrophysics, Physics::Optics, chemistry.chemical_element, Astrophysics::Cosmology and Extragalactic Astrophysics, law.invention, Lens (optics), Surface micromachining, Wavelength, Optics, chemistry, law, Computer Science::Computer Vision and Pattern Recognition, Extremely high frequency, Surface roughness, Optoelectronics, Electrical and Electronic Engineering, business, Microwave
Abstract

We have developed 220 and 440-GHz cameras using microwave kinetic inductance detectors (MKIDs) for astronomical observations. The optical system of the MKID camera is based on double-slot antennas and extended hemispherical silicon lens arrays. The lens diameter is three times the target wavelength. The 220-GHz camera and the 440-GHz camera have 9 pixels and 102 pixels, respectively. The silicon lens array has been directly machined using a high-speed spindle on an ultra-precision machine. The shape fabrication error and the surface roughness of the top of the lens were typically less than 10 μm (peak-to-valley) and about 0.7 μm (rms), respectively. The beam patterns of the MKID camera were measured and are in good agreement with the calculations.

Published
2013

34. A clinicoradiological study of odontogenic carcinomas and their impact on clinical diagnosis

Author

N Okada, Akemi Tetsumura, Tohru Kurabayashi, M Ida, and Ami Kuribayashi

Subjects
Male, medicine.medical_specialty, Gingival Neoplasm, Jaw Cysts, Dentistry, Odontogenic Tumors, Mandibular Neoplasms, Jaw neoplasm, Diagnosis, Differential, Radiography, Panoramic, medicine, Humans, Neoplasm Invasiveness, Radiology, Nuclear Medicine and imaging, General Dentistry, Early Detection of Cancer, Aged, Retrospective Studies, Maxillary Neoplasms, Gingival Neoplasms, business.industry, Research, Osteomyelitis, Age Factors, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Jaw Neoplasms, stomatognathic diseases, Otorhinolaryngology, Maxilla, Carcinoma, Squamous Cell, Female, Radiology, Differential diagnosis, Tomography, X-Ray Computed, business, Jaw Diseases
Abstract

To investigate the clinical and radiological characteristics of odontogenic carcinomas (OCs) and evaluate their impact on early clinical diagnosis.The clinical and radiological features of all patients with OCs in our pathology record from January 1988 to December 2009 were retrospectively reviewed. The impact on a tentative diagnosis before final histological examination of clinical, panoramic and CT features was investigated.Of 474 cases with malignant jaw tumours, 417 (88%) were gingival squamous cell carcinomas (SCCs) and 27 (6%) were OCs. The average age of the patients with OCs was significantly lower than that of those with gingival SCCs. 20 OCs were in the mandible and 7 were in the maxilla. 22 OC patients (81%) had pain and/or swelling as an initial symptom of the disease. Although the majority of OCs showed irregularly contoured radiolucency, one-third of the cases showed cyst-like radiolucency totally or partially surrounded by a sclerotic rim on panoramic radiography. Permeative or gross cortical bone destruction and mass extension outside the jaw bone were found on CT and a diagnosis of malignant tumour was more common. Mass extension outside the cortex had a significant influence on malignant diagnosis. However, 22% of the patients were still clinically diagnosed as having osteomyelitis after CT.Although CT was useful to obtain a diagnosis of malignant tumour in OC patients, 22% of patients were clinically diagnosed as having osteomyelitis even after CT. When an osteomyelitis case is resistant to conventional therapy and gross bone destruction and/or mass extension is found on CT, a histopathological examination should be done.

Published
2012

36. Thermogenesis induced by amino acid administration prevents intraoperative hypothermia and reduces postoperative infectious complications after thoracoscopic esophagectomy

Author

T, Fujita, N, Okada, J, Kanamori, T, Sato, S, Mayanagi, K, Torigoe, A, Oshita, H, Yamamoto, and H, Daiko

Subjects
Male, Intraoperative Care, Thoracoscopy, Blood Loss, Surgical, Thermogenesis, Hypothermia, Middle Aged, Esophagectomy, Multivariate Analysis, Humans, Lymph Node Excision, Surgical Wound Infection, Female, Amino Acids, Intraoperative Complications, Aged
Abstract

Minimally invasive thoracoscopic esophagectomy has potential advantages in minimizing the impairment of respiratory function and reducing surgical stress. However, thoracoscopic esophagectomy occasionally results in anesthesia-induced hypothermia, particularly in cases involving artificial pneumothorax with CO2. Thermogenesis induced by amino acid administration has been reported during anesthesia. Here, we tested the efficacy of amino acid treatment for the prevention of hypothermia, and we investigated the potential of this treatment to reduce postoperative infectious complications after thoracoscopic esophagectomy. We conducted a randomized trial in patients with esophageal cancer who underwent thoracoscopic esophagectomy in the prone position in two groups and analyzed the incidences of hypothermia and surgical complications. One-hundred and thirty patients were randomized. Administration of amino acids resulted in a significant increase in core body temperature. In the saline (n = 60) and amino acid (n = 70) administration groups, 30% and 14.2% of patients, respectively, experienced infectious surgical complications (P = 0.029), and 21.6% and 22.8% of patients, respectively, experienced noninfectious surgical complications (P = 0.86). Univariate analysis revealed that blood loss and amino acid administration were significant factors for infectious surgical complications. Multivariate analysis revealed that amino acid administration was an independent factor reducing infectious surgical complications (P = 0.025, 95% confidence interval: 0.105-0.864). Administration of amino acids prevents hypothermia and reduces postoperative infectious complications after thoracoscopic esophagectomy.

Published
2016

37. Enhanced photogalvanic current in topological insulators via Fermi energy tuning

Author

Atsushi Tsukazaki, Ryutaro Yoshimi, Kei S. Takahashi, Yoshinori Tokura, Ken N. Okada, Naoki Ogawa, and Masashi Kawasaki

Subjects
Photocurrent, Physics, Condensed Matter - Materials Science, Electron mobility, Spins, Condensed matter physics, Fermi level, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Fermi energy, 02 engineering and technology, Electronic structure, Electron, 021001 nanoscience & nanotechnology, 01 natural sciences, symbols.namesake, Topological insulator, 0103 physical sciences, symbols, Atomic physics, 010306 general physics, 0210 nano-technology
Abstract

We achieve the enhancement of the circular photogalvanic effect arising from the photoinjection of spins in topological insulator thin films by tuning the Fermi level $({E}_{\mathrm{F}})$. A series of ${({\mathrm{Bi}}_{1\ensuremath{-}x}{\mathrm{Sb}}_{x})}_{2}{\mathrm{Te}}_{3}$ thin films were tailored so that the Fermi energy ranges above 0.34 eV to below 0.29 eV of the Dirac point, i.e., from the bulk conduction band bottom to the valence band top through the bulk in-gap surface-Dirac cone. The circular photogalvanic current, indicating a flow of spin-polarized surface-Dirac electrons, shows a pronounced peak when the ${E}_{\mathrm{F}}$ is set near the Dirac point and is also correlated with the carrier mobility. Our observation reveals that there are substantial scatterings between the surface-Dirac and bulk state electrons in the generation process of spin-polarized photocurrent, which can be avoided by designing the electronic structure in topological insulators.

Published
2016
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38. Primary and secondary glomerulonephritis I

Author

N. Miyazaki, J. Matsumoto, F. Alberici, A. Palmisano, F. Maritati, E. Oliva, C. Buzio, A. Vaglio, G. Mjoen, G. E. Norby, B. E. Vikse, E. Svarstad, B. Rune, A. Knut, M. Szymczak, J. Kuzniar, W. Kopec, Z. Marchewka, M. Klinger, P. Arrizabalaga, R. Silvarino, F. Sant, G. Espinosa, M. Sole, R. Cervera, D. Gude, S. Chennamsetty, A. Demin, V. Kozlov, I. Lisukov, O. Kotova, A. Sizikov, V. Sergeevicheva, L. Demina, O. Borjesson, M. Wendt, A. Avik, A. R. Qureshi, J. Bratt, E. J. Miller, I. Gunnarsson, A. Bruchfeld, K. Sugiyama, M. Hasegawa, K. Yamamoto, H. Hayashi, S. Koide, K. Murakami, M. Tomita, S. Yoshida, Y. Yuzawa, S. Yew, D. Jayne, K. Westman, P. Hoglund, O. Flossman, A. Mahr, R. Luqmani, J. Robson, E. Thervet, C. Levi, E. Guiard, M. Roland, D. Nochy, C. Daniliuc, L. Guillevin, L. Mouthon, C. Jacquot, A. Karras, Y. Kimura, H. Morita, H. Debiec, H. Yamada, N. Miura, S. Banno, P. Ronco, H. Imai, D. H. Shin, D. Famee, H. M. Koo, S. H. Han, K. H. Choi, T.-H. Yoo, S.-W. Kang, C. Fofi, L. Scabbia, F. Festuccia, A. Stoppacciaro, P. Mene', A. Shimizu, M. Fukui, A. MII, T. Kaneko, Y. Masuda, Y. Iino, Y. Katayama, Y. Fukuda, A. Kuroki, K. Matsumoto, T. Akizawa, R. Jurubita, G. Ismail, R. Bobeica, E. Rusu, D. Zilisteanu, A. Andronesi, O. Motoi, V. Ditoiu, I. Copaci, M. Voiculescu, M. V. Irazabal, A. Eirin, J. C. Lieske, L. H. Beck, J. J. Dillon, P. H. Nachman, S. Sethi, S. B. Erickson, D. C. Cattran, F. C. Fervenza, B. Svobodova, Z. Hruskova, I. Janatkova, E. Jancova, V. Tesar, M. S. Seo, S. H. Kwon, E. B. Lee, J. Y. You, Y. K. Hyun, S. A. Woo, M. Y. Park, S. J. Choi, J. S. Jeon, H. Noh, J. G. Kim, D. C. Han, S. D. Hwang, T. Y. Choi, S. Y. Jin, E. Loiacono, D. Defedele, M. P. Puccinelli, R. Camilla, R. Gallo, L. Peruzzi, C. Rollino, G. Beltrame, M. Ferro, L. Vergano, F. Campolo, A. Amore, R. Coppo, T. Knoop, L. Bostad, T. Leivestad, R. Bjorneklett, J. Teranishi, R. Yamamoto, Y. Nagasawa, T. Shoji, H. Iwatani, N. Okada, T. Moriyama, A. Yamauchi, Y. Tsubakihara, E. Imai, H. Rakugi, Y. Isaka, F. M. Doh, S. J. Kim, D. S. Han, Y. Suzuki, K. Matsuzaki, H. Suzuki, K. Okazaki, H. Yanagawa, M. Maiguma, M. Muto, T. Sato, S. Horikoshi, J. Novak, O. Hotta, Y. Tomino, E. Gutierrez, I. Zamora, J. Ballarin, Y. Arce, S. Jimenez, C. Quereda, T. Olea, J. Martinez-Ara, A. Segarra, C. Bernis, A. Garcia, M. Goicoechea, S. Garcia de Vinuesa, J. Rojas, M. Praga, V. Ristovska, G. Petrushevska, L. Grcevska, K. Satake, Y. Shimizu, N. Mugitani, S. Honda, K. Shibuya, A. Shibuya, M. Papale, M. T. Rocchetti, S. DI Paolo, I. V. Suriano, A. D'apollo, G. Vocino, E. Montemurno, L. Varraso, G. Grandaliano, L. Gesualdo, A. Huerta, A. S. Bomback, P. A. Canetta, J. Radhakrishnan, L. Herlitz, B. Stokes, V. D'agati, G. Markowitz, G. B. Appel, H. Mouna, B. D. Nasr, I. Mrabet, L. Ahmed, A. Sabra, F. Mohamed Ammeur, E. Mezri, S. Habib, M. Innocenti, A. Pasquariello, G. Pasquariello, P. Mattei, A. Bottai, G. Fumagalli, L. Bozzoli, S. Samoni, A. Cupisti, B. Caldin, J. Hung, L. Repizo, D. M. Malheiros, R. Barros, V. Woronik, C. Giammarresi, L. Bono, A. Ferrantelli, C. Tortorici, G. Licavoli, U. Rotolo, X. Huang, Q. Wang, M. Shi, W. Chen, Z. Liu, R. Scarpioni, L. Cantarini, A. Lazzaro, M. Ricardi, V. Albertazzi, L. Melfa, C. Concesi, D. Vallisa, L. Cavanna, G. Gungor, H. Ataseven, A. Demir, Y. Solak, M. Biyik, B. Ozturk, I. Polat, A. Kiyici, O. Ozer Cakir, H. Polat, I. Castillo, V. Carreno, A. Aguilar, R. Madero, E. Hernandez, J. Bartolome, F. Gea, R. Selgas, H. A. M. El Aggan, H. S. El Banawy, E. Wagdy, N. Tchebotareva, O. LI, I. Bobkova, L. Kozlovskaya, V. Varshavskiy, E. Golicina, Y. Chen, Z. Gong, X. Chen, L. Tang, J. Zhou, X. Cao, R. Wei, E. H. Koo, J. H. Park, H. K. Kim, M. S. Kim, H. R. Jang, J. E. Lee, W. Huh, D. J. Kim, H. Y. Oh, Y.-G. Kim, O. Eskova, M. Shvetsov, E. Golytsina, O. Popova, M. Quaglia, S. Monti, R. Fenoglio, A. Menegotto, A. Airoldi, C. Izzo, M. A. Rizzo, U. Dianzani, P. Stratta, and D. Gianfreda

Subjects
Transplantation, Nephrology
Published
2012

39. Clinical Nephrology - Lab methods and other markers

Author

W. Kleophas, B. Bieber, B. Robinson, J. Duttlinger, D. Fliser, G. Lonneman, L. Rump, R. Pisoni, F. Port, H. Reichel, R. Daniela, A. Ciocalteu, I. A. Checherita, I. Peride, D. M. Spataru, A. Niculae, K. Laetitia, K. Amna, D. Laurence, H.-A. Aoumeur, M. Flamant, J.-P. Haymann, E. Letavernier, E. Vidal-Petiot, J.-J. Boffa, F. Vrtovsnik, F. Bianco, G. Pessolano, M. Carraro, G. O. Panzetta, N. Ebert, J. Gaedeke, O. Jakob, M. Kuhlmann, P. Martus, M. Van der Giet, E. Scha ner, I. Khan, Y. Law, K. Turgutalp, O. Ozhan, E. Gok Oguz, A. Kiykim, C. Donadio, Z. N. Hatmi, M. Mahdavi-Mazdeh, E. Morales, V. Gutierrez-Millet, J. Rojas-Rivera, A. Huerta, E. Gutierrez, E. Gutierrez-Solis, N. Polanco, J. Caro, E. Gonza z, M. Praga, M. Marco Mayayo, J. Valdivielso, M. Marti z, E. Fernaez Giraez, G. Obrador, N. Olvera, D. Ortiz de la Pe, V. Gutie ez, A. Villa, B. Redal-Baigorri, K. Sombolos, D. Tsakiris, J. Boletis, D. Vlahakos, K. Siamopoulos, V. Vargiemezis, P. Nikolaidis, C. Iatrou, E. Dafnis, C. Argyropoulos, K. Xynos, D. Schock-Kusch, Y. Shulhevich, S. Geraci, J. Hesser, D. Stsepankou, S. Neudecker, S. Koenig, F. Hoecklin, J. Pill, N. Gretz, F. Schweda, A. Schreiber, K. Kudo, T. Konta, S. O. Choi, J. S. Kim, M. K. Kim, J. W. Yang, B. G. Han, P. Delanaye, E. Cavalier, I. Masson, M. Mehdi, M. Nicolas, B. Lambermont, B. Dubois, P. Damas, J.-M. Krzesinski, J. Morel, A. Lautrette, M. Christophe, A. Gagneux-Brunon, F. Anne, L. Fre (C)ric, S. Bevc, R. Ekart, R. Hojs, M. Gorenjak, L. Puklavec, N. Hashimoto, A. Suzuki, K. Mitsumoto, M. Shimizu, K. Niihata, A. Kawabata, Y. Sakaguchi, T. Hayashi, T. Shoji, N. Okada, Y. Tsubakihara, T. Hamano, C. Nakano, N. Fujii, Y. Obi, S. Mikami, K. Inoue, I. Matsui, Y. Isaka, H. Rakugi, V. Edvardsson, B. Siguron, M. Thorsteinsdottir, R. Palsson, J. Matsumoto, N. Miyazaki, I. Murata, G. Yoshida, K. Morishita, H. Ushikoshi, K. Nishigaki, S. Ogura, S. Minatoguchi, U. Werneke, M. Ott, E. Salander-Renberg, D. Taylor, B. Stegmayr, S. Surel, M. Wenzlova, G. Silva Junior, A. P. Vieira, A. Couto Bem, M. Alves, A. Torres, G. Meneses, A. Martins, A. Liborio, E. Daher, G. Gluhovschi, M. Modilca, L. Daminescu, C. Gluhovschi, S. Velciov, L. Petrica, F. Gadalean, C. Balgradean, H. H. Schmeiser, M. Kolesnyk, N. Stepanova, L. Surzhko, N. Stashevska, V. Filiopoulos, D. Hadjiyannakos, D. Arvanitis, K. Panagiotopoulos, D. Vlassopoulos, N. Kaesler, T. Schettgen, E. Magdeleyns, V. Brandenburg, C. Vermeer, J. Floege, T. Kr, O. Randone, M. Ferraresi, E. Aroasio, A. Depascale, S. Scognamiglio, V. Consiglio, G. B. Piccoli, L. V. Jensen, S. Lizakowski, P. Rutkowski, L. Tylicki, M. Renke, B. Sulikowska, R. Donderski, R. Bednarski, Z. Heleniak, M. Przybylska, J. Manitius, B. Rutkowski, L. Bobrova, N. Kozlovskaya, K. Kanayama, M. Hasegawa, F. Kitagawa, J. Ishii, Y. Yuzawa, K. Tanaka, K. Sakai, S. Hara, Y. Suzuki, Y. Tanaka, A. Aikawa, F. Hinoshita, N. Hamano, E. Sasaki, A. Kato, T. Katsuki, A. Katsuma, E. Imai, M. Shibata, M. Tada, T. Shimbo, Y. Kikuchi, S. Oka, T. Muramatsu, N. Yanagisawa, K. Fukutake, Y. Yamamoto, A. Ajisawa, K. Tsuchiya, K. Nitta, M. Ando, X. Liang, P. Wang, Z. Liu, Z. Zhao, V. Luyckx, S. Bowker, A. Miekle, E. Toth, R. Heguilen, A. Malvar, R. Hermes, L. Cohen, G. Muguerza, B. Lococo, A. Bernasconi, O. Loboda, I. Dudar, V. Krot, V. Alekseeva, M. Ichinose, N. Sasagawa, K. Toyama, A. Saito, Y. Kayamori, D. Kang, H. W. Kim, K. Yoshioka, M. Hara, K. Ohashi, A. Maksudova, T. Khalfina, A. Cuoghi, E. Bellei, M. Caiazzo, S. Bergamini, G. Palladino, E. Monari, A. Tomasi, E. Loiacono, R. Camilla, V. Dapr, L. Morando, R. Gallo, L. Peruzzi, M. Conrieri, M. Bianciotto, F. M. Bosetti, R. Coppo, L. DI Lullo, F. Floccari, R. Rivera, A. Granata, R. Faiola, C. Feliziani, A. Villani, M. Malaguti, A. Santoboni, K. Kyriaki, J. Droulias, M. Bogdanova, V. V. Rameev, A. H. Simonyan, L. V. Kozlovskaya, M. R. Altiparmak, S. Trabulus, N. Akalin, A. S. Yalin, A. Esenkaya, S. F. Yalin, K. Serdengeae(C), D. Arita, T. Cunha, J. Perez, M. Sakata, L. Arita, M. Nogueira, Z. Jara, N. Souza, D. Casarini, M. Metzger, M. Vallet, A. Karras, M. Froissart, B. Stengel, P. Houillier, K. Paul, D. Kretzschmar, A. Yilmaz, B. Ba hlein, S. Titze, H.-R. Figulla, G. Wolf, M. Busch, Y. Korotchaeva, N. Gordovskaya, L. Kozlovskaya, K. P. Ng, P. Sharma, S. Stringer, M. Jesky, M. Dutton, C. Ferro, P. Cockwell, S. J. Moon, S. C. Lee, S. Y. Yoon, J. E. Lee, S. J. Han, B. Anna, T. Kirsch, L. Svjetlana, P. Joon-Keun, B. Jan, K. Johanna, H. Haller, M. Haubitz, A. Smirnov, I. Kayukov, N. Rafrafi, O. Degtereva, V. Dobronravov, M. Koch, H. Stefan, G. Dika, M.-H. Antoine, C. Husson, J. Kos, M. Milic, M. Fucek, D. Cvoriocec, M.-F. Bourgeade, J. L. Nortier, B. Jelakovic, E. H. Nawal, M. Naoufal, M. Nabila, E. M. Fadwa, E. K. Salma, B. Nisrine, Z. Mohamed, M. Guislaine, B. Mohamed Gharbi, R. Benyounes, G. G. Sotila, R. Sorin, D. Irina Magdalena, C. Roxana, R. Claudia, F. Correa Barcellos, P. H. Hallal, M. Bohlke, F. Boscolo Del Vechio, A. Reges, I. Santos, G. Mielke, M. Fortes, B. Antunez, M. Laganovic, I. Vukovic Lela, S. Karanovic, J. Seric, V. Premuic, M. Fitrek, L. Fodor, T. Meljkovic Vrkic, V. Bansal, D. Hoppensteadt, and J. Fareed

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Medicine, Medical physics, Clinical nephrology, business
Published
2012

40. Cardiovascular complications in CKD 5D

Author

M. Fusaro, M. Noale, G. Tripepi, A. D'angelo, D. Miozzo, M. Gallieni, P.-V. Study Group, M. Tsamelesvili, C. Dimitriadis, A. Papagianni, C. Raidis, G. Efstratiadis, D. Memmos, R. Mutluay, C. Konca Degertekin, U. Derici, S. M. Deger, F. Akkiyal, S. Gultekin, S. Gonen, G. Tacoy, T. Arinsoy, S. Sindel, C. Sanchez-Perales, E. Vazquez, E. Merino, P. Perez Del Barrio, F. J. Borrego, M. J. Borrego, A. Liebana, M. Krzanowski, K. Janda, P. Dumnicka, A. Krasniak, W. Sulowicz, Y.-O. Kim, S.-A. Yoon, Y.-S. Yun, H.-C. Song, B.-S. Kim, M. A. Cheong, A. Pasch, S. Farese, J. Floege, W. Jahnen-Dechent, T. Ohtake, R. Furuya, M. Iwagami, D. Tsutsumi, Y. Mochida, K. Ishioka, M. Oka, K. Maesato, H. Moriya, S. Hidaka, S. Kobayashi, A. Guedes, A. Malho Guedes, A. Pinho, A. Fragoso, A. Cruz, P. Mendes, E. Morgado, I. Bexiga, A. P. Silva, P. Neves, N. Oyake, K. Suzuki, S. Itoh, S. Yano, K. Turkmen, H. Kayikcioglu, O. Ozbek, M. Saglam, A. Toker, H. Z. Tonbul, S. Gelev, L. Trajceska, E. Srbinovska, S. Pavleska, V. Amitov, G. Selim, P. Dzekova, A. Sikole, H. Bouarich, S. Lopez, C. Alvarez, I. Arribas, P. DE Sequera, D. Rodriguez, S. Tanaka, T. Kanemitsu, M. Sugahara, M. Kobayashi, L. Uchida, Y. Ishimoto, N. Kotera, S. Tanimoto, K. Tanabe, K. Hara, T. Sugimoto, N. Mise, B. Goldstein, M. Turakhia, C. Arce, W. Winkelmayer, B. E.-D. Zayed, K. Said, M. Nishimura, Y. Okamoto, T. Tokoro, M. Nishida, T. Hashimoto, N. Iwamoto, H. Takahashi, T. Ono, N. Sato, J. Raimann, L. A. Usvyat, J. Sands, N. W. Levin, P. Kotanko, M. Iwasaki, N. Joki, Y. Tanaka, N. Ikeda, T. Hayashi, S. Kubo, T.-A. Imamura, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, K. Claes, B. Meijers, B. Bammens, D. Kuypers, M. Naesens, Y. Vanrenterghem, P. Evenepoel, G. Boscutti, L. Calabresi, M. Bosco, S. Simonelli, E. Boer, C. Vitali, M. Martone, P. L. Mattei, G. Franceschini, E. Baligh, E. El-Shafey, A. Ezaat, A. Zawada, K. Rogacev, B. Hummel, O. Grun, A. Friedrich, B. Rotter, P. Winter, J. Geisel, D. Fliser, G. H. Heine, J.-I. Makino, K.-S. Makino, T. Ito, S. Genovesi, A. Santoro, P. Fabbrini, E. Rossi, D. Pogliani, A. Stella, G. Bonforte, G. Remuzzi, S. Bertoli, C. Pozzi, S. Pasquali, L. Cagnoli, F. Conte, I. Buzadzic, J. Tosic, N. Dimkovic, Z. Djuric, J. Popovic, I. Pejin Grubisa, N. Barjaktarevic, A. DI Napoli, D. DI Lallo, M. F. Salvatori, F. Franco, S. Chicca, G. Guasticchi, M. Onofriescu, S. Hogas, V. Luminita, A. Mugurel, V. Gabriel, F. Laura, M. Irina, C. Adrian, E. Bosch, E. Baamonde, C. Culebras, G. Perez, B. El Hayek, J. I. Ramirez, A. Ramirez, C. Garcia, M. Lago, A. Toledo, M. D. Checa, T. Taira, T. Hirano, K. Nohtomi, T. Hyodo, T. Chiba, A. Saito, Y. K. Kim, E. J. Choi, C. W. Yang, Y.-S. Kim, P. S. Lim, W. Ming Ying, J. Ya-Chung, I. Zaripova, I. Kayukov, A. Essaian, A. Nimgirova, H. Young, M. Dungey, E. L. Watson, R. Baines, J. O. Burton, A. C. Smith, K. Yamazaki, M. Bossola, L. Colacicco, D. Scribano, C. Vulpio, L. Tazza, T. Okada, N. Okada, I. Michibata, T. Yura, N. Montero, M. Soler, M. Pascual, C. Barrios, E. Marquez, E. Rodriguez, M. A. Orfila, H. Cao, E. Arcos, J. Comas, J. Pascual, M. Ferrario, F. Garzotto, T. Sironi, S. Monacizzo, F. Basso, D. N. Cruz, U. Moissl, C. Tetta, M. G. Signorini, S. Cerutti, C. Ronco, I. Mostovaya, M. Grooteman, M. Van den Dorpel, L. Penne, N. Van der Weerd, A. Mazairac, C. Den Hoedt, R. Levesque, M. Nube, P. Ter Wee, M. Bots, P. Blankestijn, J. Liu, K. L. MA, X. Zhang, B. C. Liu, I.-D. Vladu, R. Mustafa, D. Cana-Ruiu, C. Vaduva, C. Grauntanu, E. Mota, R. Singh, N. Abbasian, C. Stover, N. Brunskill, J. Burton, K. Herbert, A. Bevington, M. Wu, R.-N. Tang, M. Gao, H. Liu, L. Chen, L.-L. LV, B.-C. Liu, M. Nikodimopoulou, S. Liakos, S. Kapoulas, C. Karvounis, D. Fedak, M. Kuzniewski, D. Paulina, B. Kusnierz-Cabala, M. Kapusta, B. Solnica, A. Junque, E. S. Vicent, L. Moreno, M. Fulquet, V. Duarte, A. Saurina, M. Pou, J. Macias, M. Lavado, M. Ramirez de Arellano, M. Ryuzaki, H. Nakamoto, S. Kinoshita, E. Kobayashi, C. Takimoto, T. Shishido, G. Enia, C. Torino, R. Tripepi, V. Panuccio, M. Postorino, A. Clementi, M. Garozzo, G. Bonanno, R. Boito, G. Natale, T. Cicchetti, A. Chippari, D. Logozzo, G. Alati, S. Cassani, A. Sellaro, C. Zoccali, B. Quiroga, E. Verde, S. Abad, A. Vega, M. Goicoechea, J. Reque, J. M. Lopez-Gomez, J. Luno, C. Cabre Menendez, V. Moles, J. P. Vives, D. Villa, J. Vinas, T. Compte, M. Arruche, C. Diaz, J. Soler, J. Aguilera, A. Martinez Vea, A. De Mauri, P. David, M. M. Conte, D. Chiarinotti, C. E. Ruva, M. De Leo, A.-S. Bargnoux, M. Morena, I. Jaussent, L. Chalabi, P. Bories, J.-J. Dion, P. Henri, M. Delage, A.-M. Dupuy, S. Badiou, B. Canaud, J.-P. Cristol, E. Sironi, F. Pieruzzi, E. Galbiati, M. R. Vigano, S. Anpalakhan, S. Rocha, N. Chitalia, R. Sharma, J. C. Kaski, J. Chambers, D. Goldsmith, D. Banerjee, V. Cernaro, A. Lacquaniti, R. Lupica, S. Lucisano, M. R. Fazio, V. Donato, M. Buemi, I. Segalen, U. Vinsonneau, T. Tanquerel, G. Quiniou, Y. Le Meur, E. Seibert, M. Girndt, K. Zohles, C. Ulrich, A. Kluttig, S. Nuding, C. Swenne, J. Kors, K. Werdan, R. Fiedler, N. C. Van der Weerd, M. P. Grooteman, M. A. Van den Dorpel, M. J. Nube, J. Wetzels, D. W. Swinkels, P. M. Ter Wee, A. Khandekar, J. Khandge, J. E. Lee, S. J. Moon, K. H. Choi, H. Y. Lee, B. S. Kim, E. Tuaillon, A. Rodriguez, L. Chenine, J.-P. Vendrell, Y.-M. Sue, C.-H. Tang, Y.-C. Chen, P. Segura, M. J. Garcia Cortes, J. M. Gil, M. M. Biechy, D. Poulikakos, A. Shah, M. Persson, P. Dattolo, M. Amidone, S. Michelassi, L. Moriconi, G. Betti, P. Conti, A. Rosati, A. Mannarino, V. Panichi, F. Pizzarelli, K. Klejna, B. Naumnik, E. Koc-Zorawska, M. Mysliwiec, S. Dimitrie, H. Simona, O. Mihaela, O. Gabriela, S. Radu, P. Octavian, H. Akdam, H. Akar, Y. Yenicerioglu, O. Kucuk, I. Kurt Omurlu, S. Thambiah, R. Roplekar, P. Manghat, I. Fogelman, W. Fraser, G. Hampson, E. Likaj, G. Caco, S. Seferi, M. Rroji, M. Barbullushi, N. Thereska, A. Serban, V. Carmen, S. Cristian, L. Silvia, and A. Covic

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2012

41. Development of Active Gas-Gap Heat Switch for Double-Stage Adiabatic Demagnetization Refrigerators

Author

H. Matsuo, Akio Hoshino, N. Okada, Hiroki Akamatsu, T. Enoki, Yoshitaka Ishisaki, T. Oshima, Takaya Ohashi, Keisuke Shinozaki, and K. Henmi

Subjects
Materials science, Thermal conductivity, Demagnetizing field, Detector, Refrigerator car, Thermodynamics, General Materials Science, Atomic physics, Condensed Matter Physics, Adiabatic process, Thermal conduction, Atomic and Molecular Physics, and Optics, Double stage
Abstract

We designed and fabricated an active gas-gap heat switch (AGGHS), which ON/OFF the heat conduction between the 1st stage (0.05–2 K) and the 2nd stage (1–4 K) of a double-stage adiabatic demagnetization refrigerator (DADR). Our design geometrically separates two components which dominates the ON or OFF performance, and achieved heat conductivity of 6 mW/K (ON) or 4 μW/K (OFF) at 2 K. The ON/OFF is controlled by a heater attached to the charcoal box to adsorb/deadsorb 4He gas inside. We introduced the AGGHS to the DADR and successfully cooled the detector stage down to 60 mK, working properly more than a year.

Published
2012

42. A Precise Analysis of C5a Inhibitory Peptide on Inflammatory Mediators Induced After Islet Transplantation

Author

W, Nakanishi, M, Goto, G, Masafumi, A, Inagaki, S, Sekiguchi, K, Fujimori, N, Okada, H, Okada, and S, Satomi

Subjects
Time Factors, Islets of Langerhans Transplantation, Complement C5a, Inflammation, Biology, Pharmacology, Proinflammatory cytokine, Interferon-gamma, Islets of Langerhans, Mice, Interferon, medicine, Animals, Interferon gamma, Blood Coagulation, Transplantation, geography, CD11b Antigen, geography.geographical_feature_category, Serine Endopeptidases, Complement System Proteins, Flow Cytometry, Islet, Rats, Gene Expression Regulation, Integrin alpha M, Immunology, biology.protein, Cytokines, Surgery, Tumor necrosis factor alpha, Inflammation Mediators, medicine.symptom, medicine.drug
Abstract

Objective We recently reported that C5a inhibitory peptide (C5aIP) prevents the instant blood-mediated inflammatory reaction by attenuating cross talk between complement and coagulation cascades. C5aIP has also been shown to possess a broad range of anti-inflammatory effects. Due to methodological limitations, it is difficult to perform detailed analyses on wide range of inflammatory mediators in rat model. Therefore, we examined whether C5aIP suppressed various inflammatory cytokines induced after islet transplantation using a mouse model. Methods Six islet equivalents per gram of syngeneic mouse islet grafts were transplanted intraportally into two groups of streptozotocin-induced diabetic mice: control group (n = 8) and C5aIP group (n = 6). The C5aIP group was treated with a bolus of 4 mg/kg just after islet infusion and a continuous infusion of 0.4 mg/kg/h, whereas the control group was injected with equivalent amounts of saline. Serum samples were collected at 0, 6, and 24 hours after transplantation. We analyzed 23 types of cytokines: interleukins-1a, -1b, -3, -4, -5, -6, -9, -10, -12, -13, and -17; eotaxin; G-CSF; GM-CSF; interferon (INF) gamma; KC; MCP-1; MIP-1 and -1b, RANTES and tumor necrosis factor-alpha. Leukocytes in the recipient liver were isolated at 6 hours after transplantation to examine IFN gamma production by fluorescence activated cell sorting (FACS). Results No significant difference was detected in terms of the major inflammatory cytokines between the two groups. INF gamma production on CD11b+Gr-1+ cells in the liver was not significantly inhibited by C5aIP (control 30.0% vs C5aIP 24.1%). Conclusions These data suggested that beneficial effects of C5aIP on islet engraftment are mainly due to blockade of cross talk between complement and coagulation cascades, rather than the suppression of inflammatory mediators.

Published
2011

43. New technology in immunology (PP-063)

Author

N. Babel, Y. Kobayashi, S. Shojaeian, Y. Aiki, H. Hiroyuki, S. Shin, C. Constantin, L. Yang, M. Magari, M. Zarkawi, T. T. Ngo, H. Kakita, V. V. Feoktistoff, H. Yagita, A. Arranz, S. Massaro, E. Kobayashi, K. Tajiri, D. Suzuki, J. Aishun, J. Y. Huang, U. Birk, L. Hwang, G. Kesa, T. Wu, K. Nagata, N. Ahlborg, Y. Tokura, A. Kosaka, M. H. Hussein, S. Hristescu, H. Okada, S. Badar, A. Abbady, K. Matsuoka, T. Mizushima, T. Watanabe, H. Suemizu, K. Jacobsen, I. Kato, Y. Tabata, T. Sawasaki, E. Sasaki, H. Ohmori, Z. Lin, T. T. Radzivil, M. Satake, S. Klages, A. Sarasa-Renedo, G. H. Daoud, N. Masataka, T. Jakobsen, K. Tani, B. Hur, M. Kohler, K. Pollinger, S. Hatakeyama, S. Sevinc, M. Suntravat, S. Fujii, H. Choi, T. Obata, A. A. Vasilyev, M. Gharagozloo, N. Tamaoki, Y. Lebranchu, S. Suzuki, M. Nose, J. Ma, J. Hecht, T. Corona-Ortega, D. Halbritter, I. Ishida, T. Sugiyama, A. A. Omran, R. Favicchio, A. M. A. Shihata, M. Lye, N. Okayama, A. Ghaderi, A. I. Sukhanov, A. Jin, S. Song, A. Muraguchi, H. Kishi, J. Ripoll, A. Al-Mariri, T. Kato, T. Ito, S. Paulie, A. K. Verma, H. Volk, L. Brix, L. Ayers, A. Planas, S. Habu, K. Sekikawa, I. Del rio-Ortiz, Y. Ong, Z. Mojtahedi, A. Thiel, M. Nobata, G. Mittler, C. Schütz, M. Nakamura, G. Zacharakis, K. Orihara, Y. Fujiwara, T. Ozawa, S. Kato, K. Mnasria, M. Dziubianau, J. Aguirre, R. Ion, H. Komori, C. Tei, S. Matsuda, T. Suguria, J. Schøller, S. Kojima, H. Takaiwa, D. Kioussis, M. Saber Firouzi, M. Abebe, M. Neagu, A. Göpferich, E. Torkabadi, V. Kumar, H. M. Vijay, H. Togari, C. Mamalaki, R. Oba, J. Williams, S. Hamasaki, K. Masjedi, P. Reinke, A. Koyanagi, A. H. Zarnani, Y. Kanehiro, Z. Bartek, C. Crowley, J. Sarvari, A. Y. El-Sayeda, M. Fleck, H. Mizuno, H. R. Mirzaei, M. Jeddi-Tehrani, A. Sattler, K. Kitamura, R. Reinhardt, K. Lee, N. Kanayama, C. Tsatsanis, I. Nuchprayoon, A. Rezaei, C. Lagaraine, K. Shiraki, R. Rangel-Corona, K. Todo, N. M. Tsuji, T. Goto, S. Cha, A. Martin, R. Oueslati, M. Kito, Y. Endo, Y. Kametani, B. Ferry, B. Weiss-Steider, K. Inoue, M. Shahrabadi, S. Muyldermans, N. Okada, A. A. Allameh, and S. Malek Hosini

Subjects
Engineering, business.industry, Immunology, Immunology and Allergy, Library science, General Medicine, business
Published
2010

44. Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

Author

Tomoko N. Okada, Mikiko C. Siomi, Yukiteru Ono, Kuniaki Saito, Taishin Kin, Yoshinori Kawamura, Takafumi Sunohara, Haruhiko Siomi, and Kiyoshi Asai

Subjects
Genetics, RNA silencing, Multidisciplinary, RNA-induced silencing complex, fungi, food and beverages, RasiRNA, Piwi-interacting RNA, Retrotransposon, Argonaute, Small nucleolar RNA, Biology, Long non-coding RNA
Abstract

RNA silencing is a conserved mechanism in which small RNAs trigger various forms of sequence-specific gene silencing by guiding Argonaute complexes to target RNAs by means of base pairing. RNA silencing is thought to have evolved as a form of nucleic-acid-based immunity to inactivate viruses and transposable elements. Although the activity of transposable elements in animals has been thought largely to be restricted to the germ line, recent studies have shown that they may also actively transpose in somatic cells, creating somatic mosaicism in animals. In the Drosophila germ line, Piwi-interacting RNAs arise from repetitive intergenic elements including retrotransposons by a Dicer-independent pathway and function through the Piwi subfamily of Argonautes to ensure silencing of retrotransposons. Here we show that, in cultured Drosophila S2 cells, Argonaute 2 (AGO2), an AGO subfamily member of Argonautes, associates with endogenous small RNAs of 20-22 nucleotides in length, which we have collectively named endogenous short interfering RNAs (esiRNAs). esiRNAs can be divided into two groups: one that mainly corresponds to a subset of retrotransposons, and the other that arises from stem-loop structures. esiRNAs are produced in a Dicer-2-dependent manner from distinctive genomic loci, are modified at their 3' ends and can direct AGO2 to cleave target RNAs. Mutations in Dicer-2 caused an increase in retrotransposon transcripts. Together, our findings indicate that different types of small RNAs and Argonautes are used to repress retrotransposons in germline and somatic cells in Drosophila.

Published
2008

45. Impact of high-temperature growth by metal-organic vapor phase epitaxy on microstructure of AlN on 6H-SiC substrates

Author

Motoaki Iwaya, Satoshi Kamiyama, N. Okada, Akira Bandoh, Isamu Akasaki, Masataka Imura, Hiroki Sugimura, and Hiroshi Amano

Subjects
Materials science, Aluminium nitride, Analytical chemistry, Mineralogy, Condensed Matter Physics, Microstructure, Epitaxy, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Impurity, Phase (matter), Materials Chemistry, Silicon carbide, Growth rate, Dislocation
Abstract

We investigated impact of high-temperature growth by metal-organic vapor phase epitaxy on crystallographic quality of AlN on 6H-SiC (0 0 0 1) Si substrate. With increasing growth temperature ( T g ), growth rate became high and residual impurities decreased. For T g =1600 °C, AlN with atomically flat surface and low dislocation density were reproducibly obtained under the high growth rate at 6 μm/h. The narrowest distribution of tilt and twist were 76 and 360 arcsec, respectively, and the average dislocation density was measured to be 7×10 8 cm −2 . Most of dislocations were of edge-type, generated by the misfit between the AlN and the SiC substrate. For increases of T g up to 1600 °C, the number of dislocations at AlN/SiC interface decreased, and many of the dislocations were annihilated by the formation of a loop structure.

Published
2008

46. High-efficiency AlGaN-based UV light-emitting diode on laterally overgrown AlN

Author

Satoshi Kamiyama, Kazuyoshi Iida, Motoaki Iwaya, Akira Bando, Fumiaki Mori, Hiroshi Amano, Hiroki Sugimura, Kentaro Nagamatsu, Isamu Akasaki, Hirotoshi Tsuzuki, and N. Okada

Subjects
Materials science, Fabrication, business.industry, Aluminium nitride, Gallium nitride, Condensed Matter Physics, Epitaxy, medicine.disease_cause, law.invention, Inorganic Chemistry, chemistry.chemical_compound, Optics, chemistry, law, Materials Chemistry, Sapphire, medicine, Optoelectronics, business, Ultraviolet, Light-emitting diode, Diode
Abstract

Ultraviolet light-emitting diodes (UV-LEDs) with a peak wavelength of 335 nm were fabricated on AlN/sapphire templates. As templates for the fabrication of UV-LEDs, planar AlN and epitaxial laterally overgrown (ELO) AlN on sapphire (0 0 0 1) substrates were compared. The output power of UV-LEDs grown on ELO-AlN was 27 times higher than that of UV-LEDs on the planar AlN template.

Published
2008

47. Mg‐doped high‐quality Al x Ga 1–x N (x=0‐1) grown by high‐temperature metal‐organic vapor phase epitaxy

Author

Isamu Akasaki, S. Kamiyama, Hiroshi Amano, T. Takagi, T. Noro, Krishnan Balakrishnan, Motoaki Iwaya, N. Okada, Masataka Imura, Akira Bandoh, and N. Kato

Subjects
Range (particle radiation), Chemistry, Doping, Analytical chemistry, Hydrogen atom, Activation energy, Condensed Matter Physics, Epitaxy, Acceptor, Metal, Computational chemistry, visual_art, Phase (matter), visual_art.visual_art_medium
Abstract

We report on the growth of Mg-doped AlxGa1–xN alloys and characterization of their optical properties. Under the low Mg concentration in the range 2×1017 to 1×1018 cm–3 of AlxGa1–xN, the activation energy of Mg acceptor became higher and higher with increase in the Al content of AlxGa1–xN. The experimental results for activation energies of Mg acceptor fitted quite well with the hydrogen atom like model. By the Haynes' rule, relationship between bound-excition energy and activation energy of Mg acceptor was investigated, which coincided with our experimental results. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Published
2007

48. Microstructure of a‐plane AlN grown on r‐plane sapphire and on patterned AlN templates by metalorganic vapor phase epitaxy

Author

Motoaki Iwaya, Hiroshi Amano, Krishnan Balakrishnan, N. Okada, Akira Bandoh, H. Maruyama, Isamu Akasaki, T. Nagai, T. Noro, Masataka Imura, T. Takagi, and Satoshi Kamiyama

Subjects
Materials science, business.industry, Vapor phase, Stacking, Nanotechnology, Slip (materials science), Condensed Matter Physics, Microstructure, Epitaxy, Template, Transmission electron microscopy, Sapphire, Optoelectronics, business
Abstract

The growth of a-plane AlN (a-AlN) on r-plane sapphire substrate and the epitaxial lateral overgrowth (ELO) of a-AlN on patterned a-AlN has been performed by high-temperature metalorganic vapor phase epitaxy. The ELO a-AlN layers coalesced well on the a-AlN template with trenches formed along 〈100〉. A detailed study of the microstructure by transmission electron microscopy revealed that the stacking faults due to facet slip are completely annihilated above the trenches of the patterned AlN. Furthermore, a dislocation density as low as 9.1×107 cm–2 was achieved by ELO. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Published
2007

49. Dislocations in AlN Epilayers Grown on Sapphire Substrate by High-Temperature Metal-Organic Vapor Phase Epitaxy

Author

Kiyotaka Nakano, Masataka Imura, Akira Bandoh, Satoshi Kamiyama, N. Okada, Naoki Fujimoto, Motoaki Iwaya, Takashi Takagi, Hiroshi Amano, Krishnan Balakrishnan, T. Noro, and Isamu Akasaki

Subjects
Diffraction, Materials science, Physics and Astronomy (miscellaneous), General Engineering, Analytical chemistry, General Physics and Astronomy, Surface finish, Epitaxy, Crystallography, Full width at half maximum, Transmission electron microscopy, Phase (matter), Grain boundary, Metalorganic vapour phase epitaxy
Abstract

The growth temperature of AlN layers is one of the most important factors in metal-organic vapor phase epitaxy (MOVPE) growth. AlN layers were grown using our customized high-temperature MOVPE system. The crystalline quality was discussed on the basis of X-ray diffraction, atomic force microscopy (AFM) and transmission electron microscopy (TEM) measurements. The samples grown at a temperature of 1400 °C had much improved crystalline quality in terms of the X-ray rocking curve full width at half maximum values and AFM root-mean-square roughness. In addition, according to TEM analysis, edge type dislocations caused by small-angle grain boundaries were predominant under a low growth temperature, whereas these dislocations became much fewer with increasing growth temperature.

Published
2007

50. Epitaxial lateral overgrowth of a-AlN layer on patterned a-AlN template by HT-MOVPE

Author

Isamu Akasaki, N. Okada, T. Noro, S. Sato, T. Sumii, Hiroshi Amano, Satoshi Kamiyama, Naoki Fujimoto, Motoaki Iwaya, Krishnan Balakrishnan, Akira Bandoh, N. Kato, Masataka Imura, and Takashi Takagi

Subjects
business.industry, Chemistry, Scanning electron microscope, Cathodoluminescence, Condensed Matter Physics, Epitaxy, Inorganic Chemistry, Template reaction, Crystallography, Transmission electron microscopy, Materials Chemistry, Sapphire, Optoelectronics, Metalorganic vapour phase epitaxy, business, Layer (electronics)
Abstract

Epitaxial lateral overgrowth (ELO) of a-plane A1N (a-AIN) has been carried out on patterned a-A1N by high-temperature metal-organic vapor phase epitaxy (HT-MOVPE). The a-A1N templates were grown on +0.5° off r-plane sapphire. The ELO a-A1N layers were found to have coalesced well on the a-A1N templates with trenches formed along , while the ELO a-A1N layers were not coalesced on the a-A1N templates with trenches formed along . Both the a-A1N template and the coalesced ELO a-A1N layer were investigated by X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), cathodoluminescence (CL) and transmission electron microscopy (TEM). Consequently, it was found that the ELO technique is useful for improving the crystalline quality of a-A1N layer by HT-MOVPE.

Published
2007

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