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Phalangeal fractures are the most common hand fractures. In the last years, intramedullary compression screw (IMHCS) for instable transverse or short oblique proximal P1 fractures have been described. Although both anterograde (intraarticular or trans-articular) and retrograde IMHCS techniques have shown good results, no comparison between anterograde and retrograde screw in P1 fractures has been published. We sought to determine stability with retrograde IMHCS and anterograde IMHCS, both trans-articular and intra-articular technique, in a cadaveric transverse proximal P1 fracture model, at two different levels.We performed a biomechanical study in 30 fresh-frozen human cadaveric P1 fracture model. Fracture was performed at 9-mm from the metacarpo-phalangeal (MCP) joint in 15 specimens, whereas it was done at 15mm in the other 15. In turn, in each group, five fractures were stabilised with an anterograde intra-articular IMHCS, five with anterograde trans-articular IMHCS and other five with retrograde IMHCS.Anterograde IMHCS fixation in 9-mm P1 fractures (both trans- and intra-articular technique, 62.74N and 70.86N, respectively) was found to be more stable than retrograde IMHCS one (32.72N) (p=0.022). Otherwise, retrograde IMHCS fixation was found to be more stable in more distal P1 fractures (90.52N retrograde vs. 57.64N trans-articular vs. 42.92N intra-articular; p=0.20).Anterograde IMHCS fixation in proximal transverse P1 bone cut in a cadaveric model provides more stability than retrograde IMHCS, while retrograde screw provides more stability when the bone cut is located more distal.

Falange proximal; Tornillo endomedular; Biomecánica Proximal phalanx; Intramedullary screw; Biomechanics Falange proximal; Cargol endomedular; Biomecànica Antecedentes y objetivo Las fracturas de falange proximal (FP) son las fracturas más frecuentes de la mano. En los últimos años, se ha descrito el uso de tornillos endomedulares sin cabeza (TESC) para las fracturas inestables transversas u oblicuas de la FP. A pesar de que tanto la técnica anterógrada como retrógrada con TESC han mostrado buenos resultados, no se ha publicado ningún estudio comparativo de su uso en fracturas de FP. Nuestro objetivo es determinar la estabilidad que se obtiene con el uso de TESC retrógrados y anterógrados en un modelo en cadáver de fractura transversa proximal de FP, a dos niveles diferentes. Material y métodos Realizamos un estudio biomecánico en 30 modelos de fractura de FP de cadáver fresco-congelado. La osteotomía se realizó a los 9 mm desde la articulación metacarpofalángica (MCF) en 15 especímenes, y a una distancia de 15 mm en los otros 15. A su vez, en cada grupo, cinco osteotomías se estabilizaron con un TESC anterógrado intraarticular, cinco mediante un TESC anterógrado transarticular y cinco con un TESC retrógrado. Resultados La fijación con TESC anterógrado en osteotomías realizadas a los 9 mm (tanto con la técnica transarticular como intraarticular, 62,74 N y 70,86 N, respectivamente) fue más estable que la fijación con TESC retrógrado (32,72 N) (p 0,022). Por otra parte, la fijación con TESC retrógrado fue más estable en el modelo de fractura más distal (90,52 N retrógrado vs. 57,64 N transarticular vs. 42,92 N intraarticular (p = 0,20). Conclusiones La fijación con TESC retrógrado ofrece más estabilidad en fracturas más distales, mientras que las técnicas anterógradas son más estables en fracturas proximales. Background and objective Phalangeal fractures are the most common hand fractures. In the last years, intramedullary compression screw (IMHCS) for instable transverse or short oblique proximal P1 fractures have been described. Although both anterograde (intraarticular or trans-articular) and retrograde IMHCS techniques have shown good results, no comparison between anterograde and retrograde screw in P1 fractures has been published. We sought to determine stability with retrograde IMHCS and anterograde IMHCS, both trans-articular and intra-articular technique, in a cadaveric transverse proximal P1 fracture model, at two different levels. Material and methods We performed a biomechanical study in 30 fresh-frozen human cadaveric P1 fracture model. Fracture was performed at 9-mm from the metacarpo-phalangeal (MCP) joint in 15 specimens, whereas it was done at 15 mm in the other 15. In turn, in each group, five fractures were stabilized with an anterograde intra-articular IMHCS, five with anterograde trans-articular IMHCS and other five with retrograde IMHCS. Results Anterograde IMHCS fixation in 9-mm P1 fractures (both trans- and intra-articular technique, 62.74 N and 70.86 N, respectively) was found to be more stable than retrograde IMHCS one (32.72 N) (p = 0.022). Otherwise, retrograde IMHCS fixation was found to be more stable in more distal P1 fractures (90.52 N retrograde vs. 57.64 N trans-articular vs. 42.92 N intra-articular; p = 0.20). Conclusions Anterograde IMHCS fixation in proximal transverse P1 bone cut in a cadaveric model provides more stability than retrograde IMHCS, while retrograde screw provides more stability when the bone cut is located more distal. El presente trabajo ha sido financiado por la Sociedad Española de Cirugía Ortopédica y Traumatología: Proyectos de Iniciación a la Investigación Fundación SECOT.

— Background and Objective: The use of cannabis has become increasingly popular in recent years, and there is ongoing debate and research on its potential effects on human health. While some studies have suggested that cannabis use can have negative effects on sexual function and fertility, there has been little research on its potential effects on penile growth. The aim of this study is to investigate the perceived relationship between cannabis use and penile growth in human males. Methods: This study used a survey approach, with a sample of 10.000 men aged 18-35 who self-reported their cannabis use and their perceptions of changes in penile growth. Participants were asked to provide information on their cannabis use habits, including frequency, duration, and method of consumption, as well as their perceptions of any changes in penile growth since they began using cannabis. Results: The results of the study showed that men who reported using cannabis had a statistically significant increase in perceived average penile length compared to those who did not use cannabis (p Conclusions: It seems that regular cannabis use does not have a negative impact on public health in a manner detectable using health indicators and could help to the growth of the penis in adult male humans.

In this work we performed a detailed numerical analysis on the static and dynamic properties of magnetic antidot arrays as a function of their geometry. In particular, we explored how by varying the shape of these antidot arrays from circular holes to stadium-shaped holes, we can effectively control the magnetic properties of the array. Using micromagnetic simulations we evidenced that coercivity is very sensitive to the shape of antidots, while the remanence is more robust to these changes. Furthermore, we studied the dynamic susceptibility of these systems, finding that it is possible to control both the position and the number of resonance peaks simply by changing the geometry of the holes. Thus, this work provides useful insights on the behavior of antidot arrays for different geometries, opening routes for the design and improvement of two-dimensional technologies.

RESUMEN: El bazo se localiza en el cuadrante superior izquierdo del abdomen, relacionándose posteriormente con la 9a a 11a costilla, de las que se separa por el diafragma y el receso costodiafragmático, se localiza por detrás del estómago y lateralmente al riñón izquierdo. Por alteraciones en su desarrollo pueden generarse bazos accesorios (BA), considerándose un tejido ectópico del bazo. Se consideran tejido normal, con los mismos procesos fisiológicos que el bazo principal. Con el propósito de localizar y determinar aspectos biométricos de los mismos, se realizó un estudio de corte transversal y de carácter descriptivo, sobre una muestra de 220 exámenes de TC pertenecientes a pacientes mayores de 18 años del Hospital Regional Hernán Henríquez Aravena, Temuco, Chile. Para este estudio se excluyeron toda aquellas TC con antecedentes de esplenectomía y lesiones de Bazo o peri-esplénicas. El análisis de los datos mostró una prevalencia de 32,3 % de BA, pudiendo ser de una única presencia, dos e incluso tres BA por paciente.De un total de 71 personas que tienen al menos un BA, 34 (47,89 %) fueron de sexo femenino y 37 (52,11 %) de sexo masculino. Hubo 56 pacientes (78,9 %) con un BA, 29 (40,85 %) del sexo femenino y 27 (38,03 %) del masculino; 15 (21,1 %) presentaron más de un BA, 5 (7,04 %) de sexo femenino y 10 (14,08 %) de sexo masculino, si bien se puede observar variación en la cantidad de BA según sexo, no existe una relación estadísticamente significativa entre dichas variables. La ubicación más frecuente encontrada en el plano axial fue la zona antero-medial con 59 casos (66,29 %); asimismo, en el plano sagital, la localización más frecuente fue en el polo inferior con 40 casos (44,44 %). Datos biométricos de estos BA son mostrados en Tablas. Esta información será de gran valor morfológico y médico debido a la escasa literatura existente sobre esta materia en individuos chilenos.

Immunodeficiency-associated CNS lymphoma may occur in different clinical scenarios beyond AIDS. This subtype of CNS lymphoma is diffuse large B-cell and Epstein-Barr virus-positive. Its accurate presurgical diagnosis is often unfeasible because it appears as ring-enhancing lesions mimicking glioblastoma or metastasis. In this article, we describe clinicoradiologic features and test the performance of DSC-PWI metrics for presurgical identification.Patients without AIDS with histologically confirmed diffuse large B-cell Epstein-Barr virus-positive primary CNS lymphoma (December 2010 to January 2022) and diagnostic MR imaging without onco-specific treatment were retrospectively studied. Clinical, demographic, and conventional imaging data were reviewed. Previously published DSC-PWI time-intensity curve analysis methodology, to presurgically identify primary CNS lymphoma, was used in this particular lymphoma subtype and compared with a prior cohort of 33 patients with Epstein-Barr virus-negative CNS lymphoma, 35 with glioblastoma, and 36 with metastasis data. Normalized curves were analyzed and compared on a point-by-point basis, and previously published classifiers were tested. The standard percentage of signal recovery and CBV values were also evaluated.Seven patients with Epstein-Barr virus-positive primary CNS lymphoma were included in the study. DSC-PWI normalized time-intensity curve analysis performed the best for presurgical identification of Epstein-Barr virus-positive CNS lymphoma (area under the receiver operating characteristic curve of 0.984 for glioblastoma and 0.898 for metastasis), followed by the percentage of signal recovery (0.833 and 0.873) and CBV (0.855 and 0.687).When a necrotic tumor is found in a potentially immunocompromised host, neuroradiologists should consider Epstein-Barr virus-positive CNS lymphoma. DSC-PWI could be very useful for presurgical characterization, with especially strong performance of normalized time-intensity curves.

Phalangeal fractures are the most common hand fractures. In the last years, intramedullary compression screw (IMHCS) for instable transverse or short oblique proximal P1 fractures have been described. Although both anterograde (intraarticular or trans-articular) and retrograde IMHCS techniques have shown good results, no comparison between anterograde and retrograde screw in P1 fractures has been published. We sought to determine stability with retrograde IMHCS and anterograde IMHCS, both trans-articular and intra-articular technique, in a cadaveric transverse proximal P1 fracture model, at two different levels.We performed a biomechanical study in 30 fresh-frozen human cadaveric P1 fracture model. Fracture was performed at 9-mm from the metacarpo-phalangeal (MCP) joint in 15 specimens, whereas it was done at 15 mm in the other 15. In turn, in each group, five fractures were stabilized with an anterograde intra-articular IMHCS, five with anterograde trans-articular IMHCS and other five with retrograde IMHCS.Anterograde IMHCS fixation in 9-mm P1 fractures (both trans- and intra-articular technique, 62.74 N and 70.86 N, respectively) was found to be more stable than retrograde IMHCS one (32.72 N) (p = 0.022). Otherwise, retrograde IMHCS fixation was found to be more stable in more distal P1 fractures (90.52 N retrograde vs. 57.64 N trans-articular vs. 42.92 N intra-articular; p = 0.20).Anterograde IMHCS fixation in proximal transverse P1 bone cut in a cadaveric model provides more stability than retrograde IMHCS, while retrograde screw provides more stability when the bone cut is located more distal.

Summary: Introduction: The analysis of the core biomarkers of Alzheimer's Disease (AD) in the cerebrospinal fluid (CSF) is recommended in the clinical units where it is available. Because of the absence of universal validated values, the determination of specific cut-off points for each center and its population is recommended. The main objective of the CORCOBIA study was to determine the cut-off points of core AD CSF biomarkers for several centers (Parc de Salut Mar, Barcelona and Hospital General de Granollers), which work with the same reference laboratory (Laboratori de Referència de Catalunya). Methods: prospective study including cognitively healthy subjects (HC, n=42), subjects with amnestic mild cognitive impairment (aMCI, n=35) and patients with dementia due to Alzheimer's Disease (AD, n=48), in whom clinical and neuropsychological assessment, neuroimaging, APOE genotyping and lumbar puncture to analyze amyloid beta peptides (Aβ42, Aβ40), total tau (tTau) and phosphorylated Tau (pTau181) using the Lumipulse G600II (Fujirebio) was performed. The values of Sensitivity (Se), Specificity (Sp), predictive values and area under the curve (AUC) were calculated, determining the cut-off point according to the Youden index by comparing the groups of HC and AD. Results: the resulting cut-offs and their AUC were the following: Aβ42 750pg/ml (AUC 0.809); Aβ42/Aβ40 0.062 (AUC 0.78); pTau181 69.85pg/ml (AUC 0.81); tTau 522.0 pg/ml (AUC 0.79); Aβ42/tTau 1.76 (AUC 0.86); Aβ42/pTau181 10.25 (AUC 0.86). Conclusions: the determination of cut-off points of core AD CSF biomarkers for the participating centers allows a better diagnostic accuracy. The ratio CSF Aβ42/pTau181 shows the highest AUC and better balance between sensitivity and specificity.

In this work, we report the excitation of spin-waves modes in skyrmion clusters hosted in Co/Pt nanodots by applying an in-plane magnetic field pulse. The direction at which the magnetic field is applied enables the excitation of five main spin-waves modes that are understood in terms of only azimuthal-like modes, which are shown to be strongly dependent on the number of skyrmions stabilized in the system. This feature converts the present system in a mechanism to activate and suppress a set of given modes, which in turn we propose to be utilized as a magnonic key based skyrmion cluster. Our results could be useful in manufacturing potential magnonic logic devices based in skyrmionic textures.

Made available in DSpace on 2022-04-28T19:45:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01 Aquaculture has tremendous importance in providing food for a growing world population. Nevertheless, unsustainable aquaculture causes nutrient buildup and favors biological invasions in natural habitats, demanding strategies to regulate such activity and therefore minimize environmental risks. Contrary to these concerns, the Brazilian Government has recently issued a new Federal Decree (10576/2020) encouraging the farming of invasive non-native species and excluding the Ministry of Environment from the legal process of issuing fish farming permits in reservoirs. The Decree increases the risk of non-native species establishment in inland waters at a national level and their propagation into neighboring countries, such as Argentina, Bolivia, Paraguay, and Uruguay. These consequences will endanger preserved freshwater ecosystems in the continent, including their native biodiversity, which represents both a problem of national sovereignty and a threat to the fundamental human right for a healthy environment. For this reason, the Decree contradicts the Brazilian Federal Constitution and conflicts with international treaties regulating invasive species and promoting sustainable development. It calls for immediate legal action and is yet another unfortunate sign of the increasing gap between science and decision making that has plagued the country in recent years. Laboratório de Ecologia Aplicada Departamento de Ciências Exatas e Biológicas Universidade Federal de São João del-Rei Núcleo de Pesquisas em Limnologia Ictiologia e Aquicultura Programa de Pós-Graduação de Ecologia de Ambientes Aquáticos Continentais Universidade Estadual de Maringá Programa de Pós-Graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos UNISANTA Instituto de Biodiversidade e Sustentabilidade Universidade Federal do Rio de Janeiro Laboratório de Ecologia e Conservação Departamento de Engenharia Ambiental Universidade Federal do Paraná Laboratório de Sistemática de Vertebrados Pontificia Universidade Católica do Rio Grande do Sul Porto Alegre Centro Nacional de Pesquisa e Conservação de Peixes Continentais (CEPTA) Instituto Nacional de Limnología Universidad Nacional del Litoral Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Laboratório de Ecologia e Conservação de Ecossistemas Aquáticos Instituto de Biociências Universidade Federal do Mato Grosso Departmento de Ecología y Gestión Ambiental Universidad de la República CURE Maldonado Belo Horizonte Instituto de Biología Universidad de Antioquia Departamento de Zoologia Universidade Estadual de São Paulo Laboratório de Ictiologia Setor de Zoologia Instituto de Biociências Universidade Federal de Mato Grosso do Sul Laboratorio de Evolución y Sistemática Facultad de Ciencias UdelaR Departamento de Zoologia Instituto de Biociências Universidade Federal do Rio Grande do Sul Dirección General de Protección y Conservación de Biodiversidad Ministerio del Ambiente y Desarrollo Sostenible Programa de Pós-Graduação em Ciências Biológicas Laboratório de Ecologia de Peixes e Invasões Biológicas (LEPIB) Universidade Estadual de Londrina Polo de Ecología Fluvial CENUR Litoral Norte – Sede Paysandú Departamento de Biodiversidade Universidade Federal do Paraná (UFPR) Núcleo de Ecologia Aquática e Pesca da Amazônia - NEAP Universidade Federal do Pará Departamento de Ecología y Evolución Facultad de Ciencias UdelaR Departamento de Ecología y Gestión Ambiental CURE Departamento de Zoologia Universidade Estadual de São Paulo

Atopic dermatitis (AD) is a chronic inflammatory skin disease with symptoms such as pruritus that can be a major burden for patients. Patient-reported outcomes (PRO) complement clinician-reported outcomes in AD. This systematic review aims to identify and describe patient-reported outcome measures (PROM) used in observational studies of AD over the last decade in Spain. Eighteen PROM were identified to measure 13 different PRO that assess multiple aspects of the disease, including symptoms and disease severity, impact on daily activities and on work productivity/functioning, psychosocial impact, patient empowerment, and health-related quality of life (HRQoL). HRQoL, symptoms (particularly pruritus), and anxiety/depression were the most frequently assessed PRO, and the Dermatology Quality of Life Index, the Visual Analogue Pruritus Scale, and the Hospital Anxiety and Depression Scale were the most frequently used PROM, respectively. The growing number of observational studies on AD including PROM in Spain suggests that PRO are becoming increasingly important in the management of AD.

International audience

This article presents a detailed analysis of the electrical performances of 3-D-printed helical-microstrip transmission lines. The transmission properties of these lines are studied theoretically. As a result, a model is proposed that consists of closed formulae for determining the characteristic impedance and the electrical length of the helical-microstrip transmission lines, as a function of electromagnetic parameters of the 3-D-printing base material and the geometry of the component. We also used the model to study the limits of compaction related to the helical geometry. The accuracy of the model is validated via finite-element method simulations and experimental results.

We study the relationship between the winding number of magnetic merons and the Gaussian curvature of two-dimensional magnetic surfaces. We show that positive (negative) Gaussian curvatures privilege merons with positive (negative) winding number. As in the case of unidimensional domain walls, we found that chirality is connected to the polarity of the core. Both effects allow to predict the topological properties of metastable states knowing the geometry of the surface. These features are related with the recently predicted Dzyaloshinskii-Moriya emergent term of curved surfaces. The presented results are at our knowledge the first ones drawing attention about a direct relation between geometric properties of the surfaces and the topology of the hosted solitons.

A 20-year retrospective review at a tertiary hospital in Singapore identified 11 cases of perinatal listeriosis in maternal–fetal pairs (incidence, 4.8 cases per 100 000 live births). Fever, meconium-stained amniotic fluid, and fetal akinesia during the third trimester were associated with listeriosis. In this study early directed antibiotic therapy resulted in favorable outcomes.

The current-driven domain wall motion in a planar nanowire with a square hole located at its center is studied by micromagnetic simulations. We show the existence of four regimes that depend both on the geometrical parameters of the hole and the nanowire, as well as on the applied current density. These regimes determine a pinning-depinning pattern characterized by: i) the domain wall remains pinned in its initial position; ii) the domain wall is released from its initial position and reaches the square hole, remaining pinned in that position; iii) the domain wall reaches the hole and passes it without major obstacles, reaching the other end of the wire; iv) the domain wall reaches the hole and suffers a series of complex transformations that annihilate it, giving rise to the nucleation of a new domain wall, which is what reaches the other end of the wire. Our finding could be of practical use in the engineering of logic devices based on the movement of domain walls.

Background. Scar-related atrial tachycardias (ATs) are very challenging and no comparative studies have been conducted between the up-to-date systems, namely the new Confidense HD coloring mapping module (HD) and the new Rhythmia (RM) mapping system. Objectives. Our study sought to compare both strategies in terms of: (1) diagnosis and immediate treatment success: (2) procedure parameters in AT presenting patients. Methods and Results. Overall, 38 patients (68±9 years old) were randomized (HD=20, RM=18). The AT mechanisms did not differ between the groups: macro/small loop reentrant mechanisms were more common in both groups (12/20 [60%] versus 10/18 [56%], P=0.9), with the remaining diagnosed as multiloop (5/20 [25%] versus 4/18 [22%]; p=0.9); focal (1/20 [5%] versus 2/18 [11%], P=0.9), and localized reentrant (2/20 [10%] versus 2/18 [11%]). The procedure parameters were as follows: tachycardia cycle length (275±30 vs. 280±50; p=0.7); number of activation maps per patient (2±1 vs 2±1; p=0.9); procedure time (138±90 vs. 139±90 min; p=0.98); X-ray time exposure (20±11 vs. 24±18 min; p=0.42); RF application time (39±36 vs. 25±28 min; p=0.21); and mean number of circuits per patient (1.8±1 vs. 1.6±0.9; 0.6). Acute success was obtained in 15/20 pts (75%) of the HD group and 14/18 (78%) of the RM group (p=0.9). The procedure failed in 2 patients with the HD coloring and they were converted to the RM group without success. No crossover was carried out in the RM group. Conclusions. This randomized study demonstrates that HD coloring and Rhythmia systems exhibit a similar efficacy in achieving acute AT termination.

We present a complete theoretical protocol to partition infrared intensities into terms owing to individual atoms by two different but related approaches: the atomic contributions (ACs) show how the entire molecular vibrational motion affects the electronic structure of a single atom and the total infrared intensity. On the other hand, the dynamic contributions (DCs) show how the displacement of a single atom alters the electronic structure of the entire molecule and the total intensity. The two analyses are complementary ways of partitioning the same total intensity and conserve most of the features of the total intensity itself. Combined, they are called the AC/DC analysis. These can be further partitioned following the CCTDP (or CCT) models according to the population analysis chosen by the researcher. The main conceptual features of the equations are highlighted, and representative numerical results are shown to support the interpretation of the equations. The results are invariant to rotation and translation and can readily be extended to molecules of any size, shape, or symmetry. Although the AC/DC analysis requires the choice of a charge model, all charge models that correctly reproduce the total molecular dipole moment can be used. A fully automated protocol managed by the Placzek program is made available, free of charge and with input examples.

This paper presents the use of additive manufacturing in the design and fabrication of a non-planar fully 3D-printed low-pass filter. The process implements stereolithographic 3D printing and copper electroplating to produce the necessary parts and their casing. The filter we produce acts as a demonstrator: we present the possibility of constructing building blocks and combining different elements into a full assembly for system integration. We introduce the “drop-and-screw” concept, which is implemented to mount the parts into a single connectorized assembly without the need for welding. The method we propose may be suitable for building other components by simply changing the building blocks. We pay special attention to the design of the constituent parts of the filter (a 3D conical inductor and a 3D capacitor), exploring new geometries to reduce the size of the final filter prototypes. The results demonstrate the potential of additive manufacturing in the construction of high-performance RF components and assemblies, and we present a modular prototype with a high degree of reconfigurability and multifunctionality.

We herein present an experiment where the concentrations of tartrazine, sunset yellow and amaranth in samples containing these three food dyes are determined by system of equations (SE) and classical least squares (CLS) multivariate calibration methods using light absorption data. Firstly, concentrations are obtained by means of the well-known SE method, that is, by solving a set of three linear equations in which the Beer-Lambert’s proportionality coefficients are obtained from analytical curves. Then, it is shown that the CLS method is a natural extension to SE, with an arbitrarily large number of equations. Nevertheless, within the CLS method, the unknown coefficients are found using mixtures with known concentrations of each dye. In order to introduce the students to the basics of algorithms and numerical computations, data treatment is performed in a command-line fashion using a freely available software. Advantages of multivariate calibration models over univariate ones are made clear, and the performance of the CLS and SE methods is compared based on the root-mean-square error

©2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. This paper presents the design and preliminary characterization of a novel 3D passive UHF-RFID tag. The prototype is fabricated using additive manufacturing techniques: 3D printing and copper electroplating. The design, manufacturing process and measurement set-up are presented and discussed in detail. We propose a biconical antenna design with helical strips in the cones to provide compactness without breaking the symmetry of the component and to improve bandwidth. The antenna is matched to a commercial UHF-RFID integrated circuit. The good agreement between results and simulations allows us to validate the whole process. This work was supported by the Spanish Ministry of Economy and Competitiveness, project TEC2017-83524-R.

The aim of this work is to fabricate and characterize a very compact branch-line coupler at the UHF band, where the wavelength is critical for miniaturization. In order to do this, the advantages of a 3D-printed electronics manufacturing process developed in former work demonstrated the usability of helical-microstrip transmission lines and allowed the materialization of a new folded topology for hybrid couplers. The design methodology and the manufacturing process have been described. A conventional hybrid coupler has been also designed, manufactured and characterized in order to compare dimensions and model simulation and prototype characterization results in terms of the scattering parameters.

International audience; Background: Updated WHO guidelines recommend a dolutegravir-based regimen as the preferred first-line treatment for HIV infection and low-dose efavirenz (400 mg) as an alternative. We aimed to report the non-inferior efficacy of dolutegravir compared with efavirenz 400 mg at week 96.Methods: We did a multicentre, randomised, open label, phase 3 trial in in three hospitals in Yaoundé, Cameroon, in HIV-1 infected antiretroviral-naive adults with an HIV RNA viral load of greater than 1000 copies per mL to compare dolutegravir 50 mg with efavirenz 400 mg (reference treatment), both combined with lamivudine and tenofovir disoproxil fumarate. The primary endpoint was the proportion with a viral load of less than 50 copies per mL at week 48 (10% non-inferiority margin). The study is registered with ClinicalTrials.gov, NCT02777229 and is ongoing.Findings: Between July, 2016, and August, 2019, of 820 patients assessed, 613 were randomly assigned to receive at least one dose of study medication, with 310 in the dolutegravir group and 303 in the efavirenz 400 mg group. At week 96 in the intention-to-treat analysis, 229 (74%) of 310 patients receiving dolutegravir and 219 (72%) of 303 patients receiving efavirenz, achieved plasma HIV-1 RNA less than 50 copies per mL (difference 1·6%, 95% CI -5·4 to 8·6; p=0.66). Viral load suppression was reached significantly more rapidly in the dolutegravir group (p1000 copies per mL) was observed in 27 patients (eight in the dolutegravir group, among which, three women switched to efavirenz 600 mg because of the dolutegravir teratogeneicity signal, and 19 in the efavirenz 400 mg group). No acquired resistance mutations to dolutegravir were observed against 17 mutations to efavirenz with or without mutations to lamivudine and tenofovir disoproxil fumarate among the 19 efavirenz 400 mg participants with virological failure. Weight gain was greater in the dolutegravir group (median weight gain, 5·0 kg in the dolutegravir group and 3·0 kg in the efavirenz 400 mg group, p