Search

Your search keyword '"NAGATA, Hirohiko"' showing total 247 results
Start Over Author "NAGATA, Hirohiko"
247 results on '"NAGATA, Hirohiko"'

19. MP49-16 WHO COULD BE EFFECTIVELY TREATED WITH ADJUVANT CHEMOTHERAPY AMONG PATHOLOGICALLY NODE POSITIVE MUSCLE INVASIVE BLADDER CANCER PATIENTS TREATED WITH RADICAL CYSTECTOMY? : A MULTICENTER COHORT STUDY ADJUSTED BY PROPENSITY SCORE MATCHING

Author

Watanabe*, Keitaro, primary, Kikuchi, Eiji, additional, Ogihara, Kohichiro, additional, Kosaka, Takeo, additional, Hakozaki, Kyohei, additional, Fukumoto, Keishiro, additional, Miyazaki, Yasumasa, additional, Shirotake, Suguru, additional, Kanai, Kunimitsu, additional, Hara, Satoshi, additional, Oyama, Masafumi, additional, Nagata, Hirohiko, additional, Monma, Tetsuo, additional, and Oya, Mototsugu, additional

Published
2020
Full Text
View/download PDF

28. Docetaxel‐based chemotherapy combined with dexamethasone 1 mg daily oral administration for castration‐resistant prostate cancer: Long‐term outcomes

Author

Tanaka, Nobumichi, primary, Nishimura, Kazuo, additional, Okajima, Eijiro, additional, Ina, Kenji, additional, Ogawa, Osamu, additional, Nagata, Hirohiko, additional, Akakura, Koichiro, additional, Fujimoto, Kiyohide, additional, Gotoh, Momokazu, additional, Teramukai, Satoshi, additional, and Hirao, Yoshihiko, additional

Published
2019
Full Text
View/download PDF

29. Incidence of seed migration to the chest, abdomen, and pelvis after transperineal interstitial prostate brachytherapy with loose 125I seeds

Author

Shiraishi Yutaka, Seki Satoshi, Mizuno Ryuichi, Nagata Hirohiko, Kunieda Etsuo, Nakashima Jun, Sugawara Akitomo, Kouta Ryuichi, Oya Mototsugu, and Shigematsu Naoyuki

Subjects
Brachytherapy, 125I, Migration, Prostate cancer, Seed, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The aim was to determine the incidence of seed migration not only to the chest, but also to the abdomen and pelvis after transperineal interstitial prostate brachytherapy with loose 125I seeds. Methods We reviewed the records of 267 patients who underwent prostate brachytherapy with loose 125I seeds. After seed implantation, orthogonal chest radiographs, an abdominal radiograph, and a pelvic radiograph were undertaken routinely to document the occurrence and sites of seed migration. The incidence of seed migration to the chest, abdomen, and pelvis was calculated. All patients who had seed migration to the abdomen and pelvis subsequently underwent a computed tomography scan to identify the exact location of the migrated seeds. Postimplant dosimetric analysis was undertaken, and dosimetric results were compared between patients with and without seed migration. Results A total of 19,236 seeds were implanted in 267 patients. Overall, 91 of 19,236 (0.47%) seeds migrated in 66 of 267 (24.7%) patients. Sixty-nine (0.36%) seeds migrated to the chest in 54 (20.2%) patients. Seven (0.036%) seeds migrated to the abdomen in six (2.2%) patients. Fifteen (0.078%) seeds migrated to the pelvis in 15 (5.6%) patients. Seed migration occurred predominantly within two weeks after seed implantation. None of the 66 patients had symptoms related to the migrated seeds. Postimplant prostate D90 was not significantly different between patients with and without seed migration. Conclusion We showed the incidence of seed migration to the chest, abdomen and pelvis. Seed migration did not have a significant effect on postimplant prostate D90.

Published
2011
Full Text
View/download PDF

30. Preimplant factors affecting postimplant CT-determined prostate volume and the CT/TRUS volume ratio after transperineal interstitial prostate brachytherapy with 125I free seeds

Author

Asakura Hirotaka, Nagata Hirohiko, Kunieda Etsuo, Nakashima Jun, Sugawara Akitomo, Oya Mototsugu, and Shigematsu Naoyuki

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The aim was to identify preimplant factors affecting postimplant prostate volume and the increase in prostate volume after transperineal interstitial prostate brachytherapy with 125I free seeds. Methods We reviewed the records of 180 patients who underwent prostate brachytherapy with 125I free seeds for clinical T1/T2 prostate cancer. Eighty-one (45%) of the 180 patients underwent neoadjuvant hormonal therapy. No patient received supplemental external beam radiotherapy. Postimplant computed tomography was undertaken, and postimplant dosimetric analysis was performed. Univariate and multivariate analyses were performed to identify preimplant factors affecting postimplant prostate volume by computed tomography and the increase in prostate volume after implantation. Results Preimplant prostate volume by transrectal ultrasound, serum prostate-specific antigen, number of needles, and number of seeds implanted were significantly correlated with postimplant prostate volume by computed tomography. The increase in prostate volume after implantation was significantly higher in patients with neoadjuvant hormonal therapy than in those without. Preimplant prostate volume by transrectal ultrasound, number of needles, and number of seeds implanted were significantly correlated with the increase in prostate volume after implantation. Stepwise multiple linear regression analysis showed that preimplant prostate volume by transrectal ultrasound and neoadjuvant hormonal therapy were significant independent factors affecting both postimplant prostate volume by computed tomography and the increase in prostate volume after implantation. Conclusions The results of the present study show that preimplant prostate volume by transrectal ultrasound and neoadjuvant hormonal therapy are significant preimplant factors affecting both postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

Published
2010
Full Text
View/download PDF

32. PD48-10 PREOPERATIVE NEUTROPHIL-TO-LYMPHOCYTE RATIO AND SMOKING HISTORY ARE INDEPENDENTLY ASSOCIATED WITH BCG RELAPSING TUMOR RECURRENCE IN NON-MUSCLE INVASIVE BLADDER CANCER PATIENTS

Author

Ogihara, Koichiro, primary, Kikuchi, Eiji, additional, Yanai, Yoshinori, additional, Takamatsu, Kimiharu, additional, Shirotake, Suguru, additional, Matsumoto, Kazuhiro, additional, Oyama, Masafumi, additional, Nagata, Hirohiko, additional, Miyajima, Akira, additional, and Oya, Mototsugu, additional

Published
2017
Full Text
View/download PDF

33. MP34-16 COULD ADJUVANT CHEMOTHERAPY HAVE THERAPEUTIC BENEFIT AFTER NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH EQUAL TO OR GREATER THAN PT3 MUSCLE INVASIVE BLADDER CANCER?

Author

Omura, Minami, primary, Kikuchi, Eiji, additional, Ogihara, Koichiro, additional, Hakozaki, Kyohei, additional, Fukumoto, Keishiro, additional, Kaneko, Go, additional, Miyazaki, Yasumasa, additional, Tanaka, Nobuyuki, additional, Shirotake, Suguru, additional, Kanai, Kunimitsu, additional, Matsumoto, Kazuhiro, additional, Nagata, Hirohiko, additional, Miyajima, Akira, additional, and Oya, Mototsugu, additional

Published
2017
Full Text
View/download PDF

35. Choriocarcinoma of the renal pelvis: a case report

Author

HARA, Satoshi, ITO, Keiichi, NAGATA, Hirohiko, TACHIBANA, Masaaki, MURAI, Masaru, and HATA, Junichi

Subjects
Renal pelvic tumor, Chemotherapy, Choriocarcinoma, 494.9, hCG-/3
Abstract

68歳男, 絨毛癌への変異を伴った腎盂移行上皮癌を経験した.尿路上皮に発生した絨毛癌は予後不良とされているが, 本症においてはMVC療法及びそれに続くPEB療法が有効であり良好な成績を得た, A 68-year-old male presented to our hospital complaining of gross hematuria. Intravenous pyelography subsequently demonstrated a left non-visualized kidney, and he was admitted for further evaluation. Cystoscopy revealed a bladder tumor around the left ureteral orifice and retrograde pyelography showed a filling defect in the left renal pelvis. The urinary cytology from the left renal pelvis indicated class IV, and the microscopic findings of a bladder biopsy demonstrated grade 1 transitional cell carcinoma. We performed transurethral resection of bladder tumor (TUR-BT) followed by left nephroureterectomy with bladder cuff. The pathological diagnosis was high grade transitional cell carcinoma with choriocarcinomatous component. After the operation, the serum human chorionic gonadotropin-beta (hCG-beta) level was slightly elevated, and the combination chemotherapy with methotrexate, vinblastine and cisplatin (MVC) was administered. Although the serum hCG-beta level fell to 0.1 ng/ml, after two courses of MVC chemotherapy, bilateral pulmonary metastases appeared in the chest X-ray with increasing hCG-beta levels. Salvage chemotherapy with cisplatin, etoposide and bleomycin (PEB) was performed. After two courses of PEB chemotherapy, the serum hCG-beta level fell to within the normal range and all pulmonary metastases disappeared.

Published
2000

37. Obstructive sleep apnea syndrome should be considered as a cause of nocturia in younger patients without other voiding symptoms

Author

Maeda, Takahiro, primary, Fukunaga, Koichi, additional, Nagata, Hirohiko, additional, Haraguchi, Mizuha, additional, Kikuchi, Eiji, additional, Miyajima, Akira, additional, Yamasawa, Wakako, additional, Shirahama, Ryutaro, additional, Narita, Midori, additional, Betsuyaku, Tomoko, additional, Asano, Koichiro, additional, and Oya, Mototsugu, additional

Published
2016
Full Text
View/download PDF

40. Embolization for massive retroperitoneal hemorrhage from adrenal pheochromocytoma: a case report

Author

ITO, Keiichi, NAGATA, Hirohiko, MIYAHARA, Makoto, SAITO, Shiro, MURAI, Masaru, and NARIMATSU, Yoshiaki

Subjects
Embolization, Adrenal hemorrhage, Pheochromocytoma, 494.9
Abstract

68歳女.後腹膜腔への大量出血を引き起こした褐色細胞腫の例を経験した.塞栓術にて止血が可能で, 全身状態の充分な回復後に手術切除し得た.血管造影及び塞栓術は, 副腎出血の有効な診断及び治療法となりうると考えた, A 68-year-old woman was found crouching in the kitchen with severe upper abdominal pain. She entered a state of shock at our emergency clinic. Abdominal computed tomography (CT) scan demonstrated a 3 cm cystic mass dorsal to the pancreas tail accompanied with a hematoma. On angiography, a bleeding from the left middle adrenal artery was identified and embolized for hemostasis. An operation was performed 3.5 months after embolization. Preoperative evaluation showed the tumor to be endocrinologically inactive. Metoclopramide stimulation test was negative, too. Left adrenalectomy was performed uneventfully without intraoperative increase in blood pressure. However, histopathological diagnosis was pheochromocytoma. Transarterial embolization is an effective treatment for adrenal bleeding. In our case, however, embolization might have caused the tumor to be falsely "endocrinologically inactive".

Published
1997

41. 1951 OBSTRUCTIVE SLEEP APNEA SYNDROME SHOULD BE CONSIDERED AS ONE OF CAUSES FOR NOCTURIA IN YOUNGER PATIENTS WITHOUT OTHER VOIDING SYMPTOM

Author

Nagata Hirohiko, Midori Narita, Koichiro Asano, Eiji Kikuchi, Koichi Fukunaga, Takahiro Maeda, Akira Miyajima, Wakako Yamasawa, Ken Nakagawa, Betsuyaku Tomoko, Takeo Kosaka, Ryutaro Shirahama, and Mototsugu Oya

Subjects
Obstructive sleep apnea, Pediatrics, medicine.medical_specialty, business.industry, Urology, medicine, Nocturia, medicine.symptom, business, medicine.disease
Published
2013
Full Text
View/download PDF

43. 腎細胞癌における上皮間葉転換に着目した新規標的分子の探索

Author

慶應義塾大学・医学部・教授, 慶應義塾大学・医学部・講師, 東京歯科大学・歯学部・教授, 慶應義塾大学・医学部・准教授, 慶應義塾大学・医学部・研究員, オオヤ, モトツグ, ミカミ, シュウジ, キクチ, エイジ, ナカガワ, ケン, ミズノ, リュウイチ, アサヌマ, ヒロシ, ミヤジマ, アキラ, ナガタ, ヒロヒコ, Oya, Mototsugu, Mikami, Shuji, Kikuchi, Eiji, Nakagawa, Ken, Mizuno, Ryuichi, Asanuma, Hiroshi, Miyajima, Akira, Nagata, Hirohiko, 大家, 基嗣, 三上, 修治, 菊地, 栄次, 中川, 健, 水野, 隆一, 浅沼, 宏, 宮嶋, 哲, 長田, 浩彦, 慶應義塾大学・医学部・教授, 慶應義塾大学・医学部・講師, 東京歯科大学・歯学部・教授, 慶應義塾大学・医学部・准教授, 慶應義塾大学・医学部・研究員, オオヤ, モトツグ, ミカミ, シュウジ, キクチ, エイジ, ナカガワ, ケン, ミズノ, リュウイチ, アサヌマ, ヒロシ, ミヤジマ, アキラ, ナガタ, ヒロヒコ, Oya, Mototsugu, Mikami, Shuji, Kikuchi, Eiji, Nakagawa, Ken, Mizuno, Ryuichi, Asanuma, Hiroshi, Miyajima, Akira, Nagata, Hirohiko, 大家, 基嗣, 三上, 修治, 菊地, 栄次, 中川, 健, 水野, 隆一, 浅沼, 宏, 宮嶋, 哲, and 長田, 浩彦

Abstract

Research team head, Research team member, Publisher, 転移を伴う腎細胞癌に対しては分子標的薬が治療の中心となり, 治療成績は向上した。しかし, 根治が難しいのは薬に効かないがん細胞が残存するからである。我々はこの残存するがん細胞の特徴として, 形態学的には肉腫瘍の変化を伴い, 上皮間葉転換をきたしており, 機序として癌幹細胞のマーカーであるCD44の高発現とTumor Necrosis Factor (TNF)-αによるCD44発現の誘導を発見した。 Molecular targeted agents are widely used and better survival benefits are shown for the treatment of metastatic renal cell carcinoma (RCC). However, there are still hurdles to conquer RCC because survival cancer cells survive. The phenotype survival cancer cells look like sarcoma suggesting epithelial- mesenchymal transition. We found out that CD44 is up-regulated in the cells where Tumor Necrosis Factor (TNF)-α induces the expression., 研究種目 : 基盤研究(B) 研究期間 : 2012～2014 課題番号 : 24390374 研究分野 : 泌尿器科学, 腫瘍学, 腎臓病学, 透析医学

Published
2015

46. Predictive factors for severe and febrile neutropenia during docetaxel chemotherapy for castration-resistant prostate cancer

Author

Shigeta, Keisuke, primary, Kosaka, Takeo, additional, Yazawa, Satoshi, additional, Yasumizu, Yota, additional, Mizuno, Ryuichi, additional, Nagata, Hirohiko, additional, Shinoda, Kazunobu, additional, Morita, Shinya, additional, Miyajima, Akira, additional, Kikuchi, Eiji, additional, Nakagawa, Ken, additional, Hasegawa, Shintaro, additional, and Oya, Mototsugu, additional

Published
2014
Full Text
View/download PDF

48. PD23-11 PROSPECTIVE EVALUATION OF EFFICACY AND SAFETY OF SOLIFENACIN AND MIRABEGRON TREATMENT IN BPH PATIENTS TREATED WITH DUTASTERIDE BUT HAVING OAB SYMPTOMS

Author

Ishioka, Katsura, primary, Kikuchi, Eiji, additional, Maeda, Takahiro, additional, Hasegawa, Masanori, additional, Kosaka, Takeo, additional, Shinojima, Toshiaki, additional, Nagata, Hirohiko, additional, Miyajima, Akira, additional, Nakagawa, Ken, additional, and Oya, Mototsugu, additional

Published
2014
Full Text
View/download PDF

50. MP16-18 DEVELOPMENT OF AN ALGORITHM FOR PREDICTING SEVERE ACUTE EPIDIDYMITIS

Author

Hongo, Hiroshi, primary, Shinojima, Toshiaki, additional, Yazawa, Satoshi, additional, Kanao, Kent, additional, Morita, Shinya, additional, Kosaka, Takeo, additional, Kono, Hidaka, additional, Mizuno, Ryuichi, additional, Kikuchi, Eiji, additional, Nagata, Hirohiko, additional, Asanuma, Hiroshi, additional, Miyajima, Akira, additional, Nakagawa, Ken, additional, Saito, Shiro, additional, and Oya, Mototsugu, additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results