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1,005 results on '"NAKAJIMA, Kazunori"'

2. Effects of Different Gum Hardness on Masseter Muscle Activity During Gum Chewing: An NIRS Oximetry Study

Author

Sakaue, Takahiro, Tsutsui, Arata, Togo, Shinji, Takeda, Tomotaka, Nakajima, Kazunori, Fukuda, Kenichi, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Series Editor, Gerlai, Robert, Series Editor, Sakatani, Kaoru, editor, Masamoto, Kazuto, editor, Yamada, Yukio, editor, Scholkmann, Felix, editor, and LaManna, Joseph C., editor

Published
2024
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3. Effect of Gum Chewing Training on Masseter Muscle Oxygen Dynamics

Author

Tsutsui, Arata, Takeda, Tomotaka, Sakaue, Takahiro, Togo, Shinji, Kanno, Susumu, Matsui, Misaki, Osawa, Kenji, Nakajima, Kazunori, Fukuda, Kenichi, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Series Editor, Gerlai, Robert, Series Editor, Sakatani, Kaoru, editor, Masamoto, Kazuto, editor, Yamada, Yukio, editor, Scholkmann, Felix, editor, and LaManna, Joseph C., editor

Published
2024
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4. Effects of Dual Tasks Including Gum Chewing on Prefrontal Cortex Activity

Author

Tsutsui, Arata, Takeda, Tomotaka, Sakaue, Takahiro, Togo, Shinji, Matsuda, Yoshiaki, Nakajima, Kazunori, Fukuda, Kenichi, Sakatani, Kaoru, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Series Editor, Gerlai, Robert, Series Editor, Sakatani, Kaoru, editor, Masamoto, Kazuto, editor, Yamada, Yukio, editor, Scholkmann, Felix, editor, and LaManna, Joseph C., editor

Published
2024
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5. De novo monoallelic Reelin missense variants cause dominant neuronal migration disorders via a dominant-negative mechanism

Author

Riva, Martina, Ferreira, Sofia, Hayashi, Kotaro, Saillour, Yoann, Medvedeva, Vera P., Honda, Takao, Hayashi, Kanehiro, Altersitz, Claire, Albadri, Shahad, Rosello, Marion, Dang, Julie, Serafini, Malo, Causeret, Frederic, Henry, Olivia J., Roux, Charles-Joris, Bellesme, Celine, Freri, Elena, Josifova, Dragana, Parrini, Elena, Guerrini, Renzo, Del Bene, Filippo, Nakajima, Kazunori, Bahi-Buisson, Nadia, and Pierani, Alessandra

Subjects
Nervous system diseases -- Diagnosis -- Care and treatment -- Genetic aspects, Cell migration -- Health aspects -- Genetic aspects, Genetic variation -- Health aspects
Abstract

Reelin (RELN) is a secreted glycoprotein essential for cerebral cortex development. In humans, recessive RELN variants cause cortical and cerebellar malformations, while heterozygous variants were associated with epilepsy, autism, and mild cortical abnormalities. However, the functional effects of RELN variants remain unknown. We identified inherited and de novo RELN missense variants in heterozygous patients with neuronal migration disorders (NMDs) as diverse as pachygyria and polymicrogyria. We investigated in culture and in the developing mouse cerebral cortex how different variants impacted RELN function. Polymicrogyria-associated variants behaved as gain-of-function, showing an enhanced ability to induce neuronal aggregation, while those linked to pachygyria behaved as loss-of-function, leading to defective neuronal aggregation/migration. The pachygyria-associated de novo heterozygous RELN variants acted as dominant-negative by preventing WT RELN secretion in culture, animal models, and patients, thereby causing dominant NMDs. We demonstrated how mutant RELN proteins in vitro and in vivo predict cortical malformation phenotypes, providing valuable insights into the pathogenesis of such disorders., Introduction The neocortex is composed of 6 layers that are built during embryonic development through highly orchestrated processes of successive generation of cohorts of glutamatergic neurons in the proliferative zones [...]

Published
2024
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8. Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study

Author

Tsutsui, Arata, Nakajima, Kazunori, Sakaue, Takahiro, Togo, Shinji, Matsuda, Yoshiaki, Takeda, Tomotaka, Fukuda, Kenichi, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Scholkmann, Felix, editor, LaManna, Joseph, editor, and Wolf, Ursula, editor

Published
2022
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14. Effect of Mastication Muscle Activity on Prefrontal Cortex NIRS Measurement: A Pilot Study

Author

Nakajima, Kazunori, Takeda, Tomotaka, Saito, Maho, Konno, Michiyo, Kawano, Yoshiaki, Suzuki, Yoshihiro, Nishino, Masayasu, Matsuda, Yoshiaki, Ishigami, Keiichi, Sakatani, Kaoru, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Ryu, Pan-Dong, editor, LaManna, Joseph C., editor, Harrison, David K., editor, and Lee, Sang-Suk, editor

Published
2020
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21. Interactions between neural cells and blood vessels in central nervous system development.

Author

Morimoto, Keiko, Tabata, Hidenori, Takahashi, Rikuo, and Nakajima, Kazunori

Subjects
BLOOD vessels, CENTRAL nervous system, BLOOD cells, HEMATOPOIESIS, INTEGRINS, NEUROGLIA
Abstract

The sophisticated function of the central nervous system (CNS) is largely supported by proper interactions between neural cells and blood vessels. Accumulating evidence has demonstrated that neurons and glial cells support the formation of blood vessels, which in turn, act as migratory scaffolds for these cell types. Neural progenitors are also involved in the regulation of blood vessel formation. This mutual interaction between neural cells and blood vessels is elegantly controlled by several chemokines, growth factors, extracellular matrix, and adhesion molecules such as integrins. Recent research has revealed that newly migrating cell types along blood vessels repel other preexisting migrating cell types, causing them to detach from the blood vessels. In this review, we discuss vascular formation and cell migration, particularly during development. Moreover, we discuss how the crosstalk between blood vessels and neurons and glial cells could be related to neurodevelopmental disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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22. PFC Blood Oxygenation Changes in Four Different Cognitive Tasks

Author

Takeda, Tomotaka, Kawakami, Yoshiaki, Konno, Michiyo, Matsuda, Yoshiaki, Nishino, Masayasu, Suzuki, Yoshihiro, Kawano, Yoshiaki, Nakajima, Kazunori, Ozawa, Toshimitsu, Kondo, Yoshihiro, Sakatani, Kaoru, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Halpern, Howard J., editor, LaManna, Joseph C., editor, Harrison, David K., editor, and Epel, Boris, editor

Published
2017
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27. Propagation of neuronal micronuclei regulates microglial states

Author

Yano, Sarasa, primary, Asami, Natsu, additional, Kishi, Yusuke, additional, Kubotani, Hikari, additional, Hattori, Yuki, additional, Kitazawa, Ayako, additional, Hayashi, Kanehiro, additional, Kubo, Ken-ichiro, additional, Saeki, Mai, additional, Maeda, Chihiro, additional, Akiyama, Kaito, additional, Okajima-Takahashi, Tomomi, additional, Sato, Ban, additional, Gotoh, Yukiko, additional, Nakajima, Kazunori, additional, Ichinohe, Takeshi, additional, Nagata, Takeshi, additional, Chiba, Tomoki, additional, and Tsuruta, Fuminori, additional

Published
2023
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30. Relationships Between Gum-Chewing and Stress

Author

Konno, Michiyo, Takeda, Tomotaka, Kawakami, Yoshiaki, Suzuki, Yoshihiro, Kawano, Yoshiaki, Nakajima, Kazunori, Ozawa, Takamitsu, Ishigami, Keiichi, Takemura, Naohiro, Sakatani, Kaoru, Elwell, Clare E., editor, Leung, Terence S., editor, and Harrison, David K., editor

Published
2016
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42. Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions

Author

Kaneko, Haruka, Kuroshima, Shinichiro, Kozutsumi, Ryohei, Al-Omari, Farah A., Hayano, Hiroki, Nakajima, Kazunori, Sawase, Takashi, Kaneko, Haruka, Kuroshima, Shinichiro, Kozutsumi, Ryohei, Al-Omari, Farah A., Hayano, Hiroki, Nakajima, Kazunori, and Sawase, Takashi

Abstract

The pathophysiology, pathogenesis, histopathology, and immunopathology of medicationrelated osteonecrosis of the jaw (MRONJ) Stage 0 remain unclear, although 50% of MRONJ Stage 0 cases could progress to higher stages. The aim of this study was to investigate the effects of zoledronate (Zol) and anti-vascular endothelial cell growth factor A (VEGFA) neutralizing antibody (Vab) administration on polarization shifting of macrophage subsets in tooth extraction sockets by creating a murine model of MRONJ Stage 0-like lesions. Eight-week-old, female C57BL/6J mice were randomly divided into 4 groups: Zol, Vab, Zol/Vab combination, and vehicle control (VC). Subcutaneous Zol and intraperitoneal Vab administration were performed for 5 weeks with extraction of both maxillary first molars 3 weeks after drug administration. Euthanasia was conducted 2 weeks after tooth extraction. Maxillae, tibiae, femora, tongues, and sera were collected. Structural, histological, immunohistochemical, and biochemical analyses were comprehensively performed. Tooth extraction sites appeared to be completely healed in all groups. However, osseous healing and soft tissue healing of tooth extraction sites were quite different. The Zol/Vab combination significantly induced abnormal epithelial healing, and delayed connective tissue healing due to decreased rete ridge length and thickness of the stratum granulosum and due to decreased collagen production, respectively. Moreover, Zol/Vab significantly increased necrotic bone area with increased numbers of empty lacunae compared with Vab and VC. Most interestingly, Zol/Vab significantly increased the number of CD169+ osteal macrophages (osteomacs) in the bone marrow and decreased F4/80+ macrophages, with a slightly increased ratio of F4/80+CD38+ M1 macrophages compared to VC. These findings are the first to provide new evidence of the involvement of osteal macrophages in the immunopathology of MRONJ Stage 0-like lesions., Journal of Clinical Medicine, 12(5), art. no. 1914; 2023

Published
2023

45. Reelin

Author

Hayashi, Kanehiro, primary, Inoue, Seika, additional, and Nakajima, Kazunori, additional

Published
2018
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