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2,358 results on '"NAKAMURA, Takahiro"'

5. Age-Related Decline in the Central Circadian Clock

Author

Miyazaki, Shota, Nakamura, Wataru, Nakamura, Takahiro J., Rattan, Suresh I.S., Editor-in-Chief, Barbagallo, Mario, Editorial Board Member, Çakatay, Ufuk, Editorial Board Member, Fraifeld, Vadim E., Editorial Board Member, Fülöp, Tamàs, Editorial Board Member, Gruber, Jan, Editorial Board Member, Jin, Kunlin, Editorial Board Member, Kaul, Sunil, Editorial Board Member, Kaur, Gurcharan, Editorial Board Member, Le Bourg, Eric, Editorial Board Member, Lopez Lluch, Guillermo, Editorial Board Member, Moskalev, Alexey, Editorial Board Member, Nehlin, Jan, Editorial Board Member, Pawelec, Graham, Editorial Board Member, Rizvi, Syed Ibrahim, Editorial Board Member, Sholl, Jonathan, Editorial Board Member, Stambler, Ilia, Editorial Board Member, Szczerbińska, Katarzyna, Editorial Board Member, Trougakos, Ioannis P., Editorial Board Member, Wadhwa, Renu, Editorial Board Member, Wnuk, Maciej, Editorial Board Member, and Jagota, Anita, editor

Published
2023
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6. Chronic methamphetamine uncovers a circadian rhythm in multiple-unit neural activity in the dorsal striatum which is independent of the suprachiasmatic nucleus

Author

Miyazaki, Shota, Tahara, Yu, Colwell, Christopher S, Block, Gene D, Nakamura, Wataru, and Nakamura, Takahiro J

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Neurosciences, Methamphetamine, Brain Disorders, Sleep Research, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Circadian rhythm, Dopamine, Multiple unit neural activity, Striatum, Suprachiasmatic nucleus, Wheel running activity, constant dark, dopamine transporter, dopamine, light-dark, methamphetamine, multiple unit neural activity, suprachiasmatic nucleus, wheel running, Biological psychology
Abstract

The dorsal striatum forms part of the basal ganglia circuit that is a major regulator of voluntary motor behavior. Dysfunction in this circuit is a critical factor in the pathology of neurological (Parkinson's and Huntington's disease) as well as psychiatric disorders. In this study, we employed in vivo real-time monitoring of multiple unit neural activity (MUA) in the dorsal striatum of freely moving mice. We demonstrate that the striatum exhibits robust diurnal and circadian rhythms in MUA that peak in the night. These rhythms are dependent upon the central circadian clock located in the suprachiasmatic nucleus (SCN) as lesions of this structure caused the loss of rhythmicity measured in the striatum. Nonetheless, chronic treatment of methamphetamine (METH) makes circadian rhythms appear in MUA recorded from the striatum of SCN-lesioned mice. These data demonstrate that the physiological properties of neurons in the dorsal striatum are regulated by the circadian system and that METH drives circadian rhythms in striatal physiology in the absence of the SCN. The finding of SCN-driven circadian rhythms in striatal physiology has important implications for an understanding of the temporal regulation of motor control as well as revealing how disease processes may disrupt this regulation.

Published
2021

7. Impact of Lesion Location on Recurrence After Resection of T1 Colorectal Cancer: Post Hoc Analysis of a Nationwide Multicenter Cohort Study

Author

Sugihara, Kenichi, Saito, Shoichi, Fukunaga, Yusuke, Kawachi, Hiroshi, Takamatsu, Manabu, Kojima, Motohiro, Hotta, Kinichi, Yamada, Masayoshi, Kanemitsu, Yukihide, Saito, Yutaka, Sekine, Shigeki, Tanaka, Shinji, Nagata, Shinji, Nakamura, Takahiro, Yamada, Kazutaka, Konno, Maki, Ishihara, Soichiro, Saitoh, Yusuke, Matsuda, Kenji, Togashi, Kazutomo, Komori, Koji, Ishiguro, Megumi, Kuwai, Toshio, Okuyama, Takashi, Ohuchi, Akihiro, Ohnuma, Shinobu, Sakamoto, Kazuhiro, Sugai, Tamotsu, Katsumata, Kenji, Matsushita, Hiro-o, Yamano, Hiro-o, Nakai, Keisuke, Uraoka, Toshio, Akimoto, Naohiko, Kobayashi, Hirotoshi, Minamide, Tatsunori, Ikematsu, Hiroaki, Kajiwara, Yoshiki, Oka, Shiro, Ajioka, Yoichi, and Ueno, Hideki

Published
2024
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10. Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus

Author

Michel, Stephan, Nakamura, Takahiro J, Meijer, Johanna H, and Colwell, Christopher S

Subjects
Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Neurosciences, Sleep Research, 1.1 Normal biological development and functioning, Underpinning research, Neurological, Animals, Calcium Signaling, Circadian Rhythm, Electroencephalography, Evoked Potentials, Mice, Microelectrodes, Patch-Clamp Techniques, Suprachiasmatic Nucleus, Biological clock, Brain slice, Circadian, In vivo electrophysiology, Neural activity rhythms, Suprachiasmatic nucleus, Other Chemical Sciences, Developmental Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry
Abstract

In mammals, the part of the nervous system responsible for most circadian behavior can be localized to a bilaterally paired structure in the hypothalamus known as the suprachiasmatic nucleus (SCN). Understanding the mammalian circadian system will require a detailed multilevel analysis of neural SCN circuits ex vivo and in vivo. Many of the techniques and approaches that are used for the analysis of the circuitry driving circadian oscillations in the SCN are similar to those employed in other brain regions. There is, however, one fundamental difference that needs to be taken into consideration, that is, the physiological, cell, and molecular properties of SCN neurons vary with the time of day. In this chapter, we will consider the preparations and electrophysiological techniques that we have used to analyze the SCN circuit focusing on the acute brain slice and intact, freely moving animal.

Published
2021

11. SWOT analysis of noninvasive tests for diagnosing NAFLD with severe fibrosis: an expert review by the JANIT Forum

Author

Kamada, Yoshihiro, Nakamura, Takahiro, Isobe, Satoko, Hosono, Kumiko, Suama, Yukiko, Ohtakaki, Yukie, Nauchi, Arihito, Yasuda, Naoto, Mitsuta, Soh, Miura, Kouichi, Yamamoto, Takuma, Hosono, Tatsunori, Yoshida, Akihiro, Kawanishi, Ippei, Fukushima, Hideaki, Kinoshita, Masao, Umeda, Atsushi, Kinoshita, Yuichi, Fukami, Kana, Miyawaki, Toshio, Fujii, Hideki, Yoshida, Yuichi, Kawanaka, Miwa, Hyogo, Hideyuki, Morishita, Asahiro, Hayashi, Hideki, Tobita, Hiroshi, Tomita, Kengo, Ikegami, Tadashi, Takahashi, Hirokazu, Yoneda, Masato, Jun, Dae Won, Sumida, Yoshio, Okanoue, Takeshi, and Nakajima, Atsushi

Published
2023
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13. Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study

Author

Kajiwara, Yoshiki, Oka, Shiro, Tanaka, Shinji, Nakamura, Takahiro, Saito, Shoichi, Fukunaga, Yosuke, Takamatsu, Manabu, Kawachi, Hiroshi, Hotta, Kinichi, Ikematsu, Hiroaki, Kojima, Motohiro, Saito, Yutaka, Yamada, Masayoshi, Kanemitsu, Yukihide, Sekine, Shigeki, Nagata, Shinji, Yamada, Kazutaka, Kobayashi, Nozomu, Ishihara, Soichiro, Saitoh, Yusuke, Matsuda, Kenji, Togashi, Kazutomo, Komori, Koji, Ishiguro, Megumi, Kuwai, Toshio, Okuyama, Takashi, Ohuchi, Akihiro, Ohnuma, Shinobu, Sakamoto, Kazuhiro, Sugai, Tamotsu, Katsumata, Kenji, Matsushita, Hiro-o, Yamano, Hiro-o, Eda, Hirotsugu, Uraoka, Toshio, Akimoto, Naohiko, Kobayashi, Hirotoshi, Ajioka, Yoichi, Sugihara, Kenichi, and Ueno, Hideki

Published
2023
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14. Optimal bowel resection margin in colon cancer surgery: prospective multicentre cohort study with lymph node and feeding artery mapping

Author

Ueno, Hideki, Hase, Kazuo, Shiomi, Akio, Shiozawa, Manabu, Ito, Masaaki, Sato, Toshihiko, Hashiguchi, Yojiro, Kusumi, Takaya, Kinugasa, Yusuke, Ike, Hideyuki, Matsuda, Kenji, Yamada, Kazutaka, Komori, Koji, Takahashi, Keiichi, Kanemitsu, Yukihide, Ozawa, Heita, Ohue, Masayuki, Masaki, Tadahiko, Takii, Yasumasa, Ishibe, Atsushi, Watanabe, Jun, Toiyama, Yuji, Sonoda, Hiromichi, Koda, Keiji, Akagi, Yoshito, Itabashi, Michio, Nakamura, Takahiro, and Sugihara, Kenichi

Published
2023
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16. Test Characteristics of Cross-sectional Imaging and Concordance With Endoscopy in Postoperative Crohn’s Disease

Author

Bachour, Salam P., Shah, Ravi S., Lyu, Ruishen, Nakamura, Takahiro, Shen, Michael, Li, Terry, Dane, Bari, Barnes, Edward L., Rieder, Florian, Cohen, Benjamin, Qazi, Taha, Lashner, Bret, Achkar, Jean Paul, Philpott, Jessica, Holubar, Stefan D., Lightner, Amy L., Regueiro, Miguel, Axelrad, Jordan, Baker, Mark E., and Click, Benjamin

Published
2022
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18. A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility

Author

Chang, Shun-Jen, Toyoda, Yu, Kawamura, Yusuke, Nakamura, Takahiro, Nakatochi, Masahiro, Nakayama, Akiyoshi, Liao, Wei-Ting, Shimizu, Seiko, Takada, Tappei, Takeuchi, Kenji, Wakai, Kenji, Shi, Yongyong, Shinomiya, Nariyoshi, Chen, Chung-Jen, Li, Changgui, Okada, Yukinori, Ichida, Kimiyoshi, and Matsuo, Hirotaka

Published
2022
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19. The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure

Author

Ito, Shogo, Hashimoto, Hisayuki, Yamakawa, Hiroyuki, Kusumoto, Dai, Akiba, Yohei, Nakamura, Takahiro, Momoi, Mizuki, Komuro, Jin, Katsuki, Toshiomi, Kimura, Mai, Kishino, Yoshikazu, Kashimura, Shin, Kunitomi, Akira, Lachmann, Mark, Shimojima, Masaya, Yozu, Gakuto, Motoda, Chikaaki, Seki, Tomohisa, Yamamoto, Tsunehisa, Shinya, Yoshiki, Hiraide, Takahiro, Kataoka, Masaharu, Kawakami, Takashi, Suzuki, Kunimichi, Ito, Kei, Yada, Hirotaka, Abe, Manabu, Osaka, Mizuko, Tsuru, Hiromi, Yoshida, Masayuki, Sakimura, Kenji, Fukumoto, Yoshihiro, Yuzaki, Michisuke, Fukuda, Keiichi, and Yuasa, Shinsuke

Published
2022
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23. Optimal Maintenance Policies of Wave-Dissipating Blocks Using Cumulative Damage Model.

Author

Nakamura, Takahiro, Dong, Yunlong, Ito, Kodo, and Higuchi, Yoshiyuki

Subjects
INFRASTRUCTURE (Economics), DAMAGE models, LABOR supply, MAINTENANCE costs, NATURAL disasters
Abstract

Different types of social infrastructure, such as roads and bridges, are essential and necessary for supporting our daily lives and economic operations. Because 39% of Japan's road bridges and 27% of its tunnels will have been in use for 50 years or more by 2023, maintaining them has become a significant national concern (Ministry of Land, Infrastructure, Transport and Tourism, White Paper on Land, Infrastructure, Transport and Tourism in Japan (2017), p. 114). Because of the declining birthrate, the deteriorating labor force, and the weakening local economy, the Japanese government must maintain these social infrastructures while facing severe budgetary challenges. And efficient and economical maintenance strategies and plans are required. This paper proposes optimal maintenance policies which consider the unique circumstances of social infrastructure and minimize maintenance costs. By applying these policies to wave-dissipating blocks in Japan, the effectiveness of them is confirmed. [ABSTRACT FROM AUTHOR]

Published
2024
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32. In situ 3D X-ray imaging of water distribution in each layer of a membrane electrode assembly of a polymer electrolyte fuel cell.

Author

Matsui, Hirosuke, Ohta, Tomoro, Nakamura, Takahiro, Uruga, Tomoya, and Tada, Mizuki

Abstract

In situ 3D computed tomography imaging with statistical analysis successfully revealed the water accumulation and drainage characteristics in the stacked gas diffusion layers (GDLs) and membrane electrode assembly (MEA) of a polymer electrolyte fuel cell. Efficient water drainage at the interface between the cathode GDL and MEA was confirmed upon supplying oxygen to the cathode. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Systems for Disaster Management in the Private Sector

Author

Suga, Mashiho, Kuwana, Kinzo, Nagamatsu, Shingo, Nakamura, Takahiro, Takano, Kazuhiko, Inoguchi, Takashi, Editor-in-Chief, Hasegawa, Mariko, Series Editor, Kameda, Tatsuya, Series Editor, Keane, John, Series Editor, Takahashi, Taiki, Series Editor, Vogel, Ezra, Series Editor, Abe, Seiji, editor, Ozawa, Mamoru, editor, and Kawata, Yoshiaki, editor

Published
2019
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34. Social Disasters and Damages

Author

Nakamura, Takahiro, Kanoshima, Emiko, Koyama, Tomofumi, Nishimura, Hiroshi, Ozawa, Mamoru, Inoguchi, Takashi, Editor-in-Chief, Hasegawa, Mariko, Series Editor, Kameda, Tatsuya, Series Editor, Keane, John, Series Editor, Takahashi, Taiki, Series Editor, Vogel, Ezra, Series Editor, Abe, Seiji, editor, Ozawa, Mamoru, editor, and Kawata, Yoshiaki, editor

Published
2019
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36. Diurnal variation of brain activity in the human suprachiasmatic nucleus

Author

Oka, Satoshi, primary, Ogawa, Akitoshi, additional, Osada, Takahiro, additional, Tanaka, Masaki, additional, Nakajima, Koji, additional, Kamagata, Koji, additional, Aoki, Shigeki, additional, Oshima, Yasushi, additional, Tanaka, Sakae, additional, Kirino, Eiji, additional, Nakamura, Takahiro J., additional, and Konishi, Seiki, additional

Published
2024
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37. Impact of Lesion Location on Recurrence After Resection of T1 Colorectal Cancer: Post Hoc Analysis of a Nationwide Multicenter Cohort Study

Author

Minamide, Tatsunori, primary, Ikematsu, Hiroaki, additional, Kajiwara, Yoshiki, additional, Oka, Shiro, additional, Ajioka, Yoichi, additional, Ueno, Hideki, additional, Sugihara, Kenichi, additional, Saito, Shoichi, additional, Fukunaga, Yusuke, additional, Kawachi, Hiroshi, additional, Takamatsu, Manabu, additional, Kojima, Motohiro, additional, Hotta, Kinichi, additional, Yamada, Masayoshi, additional, Kanemitsu, Yukihide, additional, Saito, Yutaka, additional, Sekine, Shigeki, additional, Tanaka, Shinji, additional, Nagata, Shinji, additional, Nakamura, Takahiro, additional, Yamada, Kazutaka, additional, Konno, Maki, additional, Ishihara, Soichiro, additional, Saitoh, Yusuke, additional, Matsuda, Kenji, additional, Togashi, Kazutomo, additional, Komori, Koji, additional, Ishiguro, Megumi, additional, Kuwai, Toshio, additional, Okuyama, Takashi, additional, Ohuchi, Akihiro, additional, Ohnuma, Shinobu, additional, Sakamoto, Kazuhiro, additional, Sugai, Tamotsu, additional, Katsumata, Kenji, additional, Matsushita, Hiro-o, additional, Yamano, Hiro-o, additional, Nakai, Keisuke, additional, Uraoka, Toshio, additional, Akimoto, Naohiko, additional, and Kobayashi, Hirotoshi, additional

Published
2024
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39. Recovery from Age-Related Infertility under Environmental Light-Dark Cycles Adjusted to the Intrinsic Circadian Period

Author

Takasu, Nana N, Nakamura, Takahiro J, Tokuda, Isao T, Todo, Takeshi, Block, Gene D, and Nakamura, Wataru

Subjects
Biological Sciences, Sleep Research, Estrogen, Infertility, Contraception/Reproduction, Aging, Underpinning research, 1.1 Normal biological development and functioning, Reproductive health and childbirth, Good Health and Well Being, Animals, Circadian Rhythm, Cryptochromes, Estrous Cycle, Female, Fertility, Mice, Mice, Inbred C57BL, Photoperiod, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Female reproductive function changes during aging with the estrous cycle becoming more irregular during the transition to menopause. We found that intermittent shifts of the light-dark cycle disrupted regularity of estrous cycles in middle-aged female mice, whose estrous cycles were regular under unperturbed 24-hr light-dark cycles. Although female mice deficient in Cry1 or Cry2, the core components of the molecular circadian clock, exhibited regular estrous cycles during youth, they showed accelerated senescence characterized by irregular and unstable estrous cycles and resultant infertility in middle age. Notably, tuning the period length of the environmental light-dark cycles closely to the endogenous one inherent in the Cry-deficient females restored the regularity of the estrous cycles and, consequently, improved fertility in middle age. These results suggest that reproductive potential can be strongly influenced by age-related changes in the circadian system and normal reproductive functioning can be rescued by the manipulation of environmental timing signals.

Published
2015

40. Age-Related Changes in the Circadian System Unmasked by Constant Conditions

Author

Nakamura, Takahiro J, Nakamura, Wataru, Tokuda, Isao T, Ishikawa, Takahiro, Kudo, Takashi, Colwell, Christopher S, and Block, Gene D

Subjects
Aging, Sleep Research, Underpinning research, 1.1 Normal biological development and functioning, aging, imaging, PER2:: luciferase, suprachiasmatic nucleus, PER2::luciferase, Neurosciences
Abstract

Circadian timing systems, like most physiological processes, cannot escape the effects of aging. With age, humans experience decreased duration and quality of sleep. Aged mice exhibit decreased amplitude and increased fragmentation of the activity rhythm, and lengthened circadian free-running period in both light-dark (LD) and constant dark (DD) conditions. Several studies have shown that aging impacts neural activity rhythms in the central circadian clock in the suprachiasmatic nucleus (SCN). However, evidence for age-related disruption of circadian oscillations of clock genes in the SCN has been equivocal. We hypothesized that daily exposure to LD cycles masks the full impact of aging on molecular rhythms in the SCN. We performed ex vivo bioluminescent imaging of cultured SCN slices of young and aged PER2::luciferase knock-in (PER2::LUC) mice housed under LD or prolonged DD conditions. Under LD conditions, the amplitude of PER2::LUC rhythms differed only slightly between SCN explants from young and aged animals; under DD conditions, the PER2::LUC rhythms of aged animals showed markedly lower amplitudes and longer circadian periods than those of young animals. Recordings of PER2::LUC rhythms in individual SCN cells using an electron multiplying charge-coupled device camera revealed that aged SCN cells showed longer circadian periods and that the rhythms of individual cells rapidly became desynchronized. These data suggest that aging degrades the SCN circadian ensemble, but that recurrent LD cycles mask these effects. We propose that these changes reflect a decline in pacemaker robustness that could increase vulnerability to environmental challenges, and partly explain age-related sleep and circadian disturbances.

Published
2015

42. Development of Superconducting Tunnel Junction Detector Using Hafnium for COBAND Experiment

Author

Takemasa, Kenichi, Kim, Shinhong, Takeuchi, Yuji, Nagata, Kazuki, Kasahara, Kota, Yagi, Shunsuke, Wakasa, Rena, Asano, Chisa, Ootuka, Youiti, Mima, Satoru, Kiuchi, Kenji, Arai, Yasuo, Kurachi, Ikuo, Hazumi, Masashi, Ishino, Hirokazu, Kibayashi, Atsuko, Yoshida, Takuo, Sakai, Makoto, Nakamura, Takahiro, Kato, Yukihiro, Matsuura, Shuji, Kawahito, Shoji, Ikeda, Hirokazu, Wada, Takehiko, Nagase, Koichi, Baba, Shunsuke, Shiki, Shigetomo, Ukibe, Masahiro, Fujii, Go, Ohkubo, Masataka, Ramberg, Erik, Kozlovsky, Mark, Rubinov, Paul, Yoo, Jonghee, Sergatskov, Domitri A., Kim, Soo-Bong, and Liu, Zhen-An, editor

Published
2018
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45. Highlights of the 14th Japan Bioanalysis Forum Symposium

Author

Arakawa, Tomoko, primary, Nishiguchi, Yumi, additional, Hashimoto, Masayo, additional, Mabuchi, Masanari, additional, Koyama, Noriyuki, additional, Niwa, Makoto, additional, Yamaguchi, Takeru, additional, Yoshinaga, Ryosuke, additional, Takamatsu, Yuki, additional, Komaba, Junji, additional, Nakamura, Takahiro, additional, Saito, Tetsu, additional, Ohtsu, Yoshiaki, additional, Takahashi, Makoto, additional, Yagi, Ryotaro, additional, Hanari, Suguru, additional, Hashimoto, Yoshitaka, additional, and Uchihashi, Shinsuke, additional

Published
2023
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46. Endothelial-fibroblast interactions during Scarb1 accelerate heart failure

Author

Katsuki, Toshiomi, primary, Kusumoto, Dai, additional, Akiba, Yohei, additional, Kimura, Mai, additional, Komuro, Jin, additional, Nakamura, Takahiro, additional, Hashimoto, Hisayuki, additional, Kuoka, Thukaa, additional, Suzuki, Yutaka, additional, Kubota, Yoshiaki, additional, Fukuda, Keiichi, additional, Yuasa, Shinsuke, additional, and Ieda, Masaki, additional

Published
2023
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