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1,989 results on '"NISHIMURA, Masaharu"'

3. Applicable predictive factors extracted from peak flow trajectory for the prediction of asthma exacerbation

Author

Isada, Akira, Hattori, Takeshi, Shimizu, Kenichi, Yoshida, Takayuki, Nagaoka, Kentaro, Nakane, Shinji, Saito, Yoshiyuki, Sasaki, Tsukasa, Honda, Hideko, Deai, Miho, Muramoto, Ayako, Kudo, Natsumi, Sato, Nozomi, Suzuki, Masanobu, Saito, Hiroshi, Kojima, Tetsuya, Ichimura, Shiho, Choji, Takashi, Kobayashi, Motoko, Ishikuro, Akihiko, Ohtsuka, Yoshihiro, Honmura, Fumihiro, Akiyama, Yasushi, Harada, Toshiyuki, Kamimura, Akira, Tashiro, Norio, Mikami, Hiroshi, Ohmichi, Mitsuhide, Sugawara, Yoshitaka, Takahashi, Toshiki, Yamamoto, Makoto, Takamura, Kei, Tokuchi, Yoshio, Inoue, Yuji, Shigehara, Katsunori, Ukita, Hideaki, Kikuchi, Kouki, Koba, Hiroyuki, Sekine, Kyuichirou, Nakano, Tsuyoshi, Ohata, Yoshihiro, Ohnuma, Noritomo, Sato, Fumihiko, Taguchi, Hiroyuki, Sugawara, Hiroyuki, Honjo, Osamu, Togashi, Seiya, Nishikiori, Hirotaka, Kitada, Junya, Fujii, Masaru, Shibuya, Eiji, Tanaka, Hiroshi, Okamoto, Yoshihiro, Hiroumi, Hiromitsu, Watanabe, Kazuhiko, Yang, Yichi, Kimura, Hirokazu, Yokota, Isao, Makita, Hironi, Takimoto-Sato, Michiko, Matsumoto-Sasaki, Machiko, Matsumoto, Munehiro, Oguma, Akira, Abe, Yuki, Takei, Nozomu, Goudarzi, Houman, Shimizu, Kaoruko, Suzuki, Masaru, Nishimura, Masaharu, and Konno, Satoshi

Published
2024
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11. Further evidence for association of YKL-40 with severe asthma airway remodeling

Author

Kimura, Hirokazu, Shimizu, Kaoruko, Tanabe, Naoya, Makita, Hironi, Taniguchi, Natsuko, Kimura, Hiroki, Suzuki, Masaru, Abe, Yuki, Matsumoto-Sasaki, Machiko, Oguma, Akira, Takimoto-Sato, Michiko, Takei, Nozomu, Matsumoto, Munehiro, Goudarzi, Houman, Sato, Susumu, Ono, Junya, Izuhara, Kenji, Hirai, Toyohiro, Nishimura, Masaharu, and Konno, Satoshi

Published
2022
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13. Effects of obesity on CC16 and their potential role in overweight/obese asthma

Author

Goudarzi, Houman, Kimura, Hirokazu, Kimura, Hiroki, Makita, Hironi, Matsumoto, Munehiro, Takei, Nozomu, Shimizu, Kaoruko, Suzuki, Masaru, Watanabe, Taku, Kikuchi, Eiki, Ohira, Hiroshi, Tsujino, Ichizo, Sakakibara-Konishi, Jun, Shinagawa, Naofumi, Shijubo, Noriharu, Sato, Hirokazu, Shigehara, Katsunori, Kaga, Kichizo, Hida, Yasuhiro, Murakami, Soichi, Ebihara, Yuma, Nakamura, Akinobu, Miyoshi, Hideaki, Hirano, Satoshi, Hizawa, Nobuyuki, Atsumi, Tatsuya, Huang, Shau-ku, Ito, Yoichi M., Nishimura, Masaharu, and Konno, Satoshi

Published
2022
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15. Delta-like 1 homolog (DLK1) as a possible therapeutic target and its application to radioimmunotherapy using 125I-labelled anti-DLK1 antibody in lung cancer models (HOT1801 and FIGHT004)

Author

Takagi, Hironori, Zhao, Songji, Muto, Satoshi, Yokouchi, Hiroshi, Nishihara, Hiroshi, Harada, Toshiyuki, Yamaguchi, Hikaru, Mine, Hayato, Watanabe, Masayuki, Ozaki, Yuki, Inoue, Takuya, Yamaura, Takumi, Fukuhara, Mitsuro, Okabe, Naoyuki, Matsumura, Yuki, Hasegawa, Takeo, Osugi, Jun, Hoshino, Mika, Higuchi, Mitsunori, Shio, Yutaka, Kanno, Ryuzo, Aoki, Miho, Tan, Chengbo, Shimoyama, Saki, Yamazaki, Shigeo, Kikuchi, Hajime, Sakakibara-Konishi, Jun, Oizumi, Satoshi, Harada, Masao, Akie, Kenji, Sugaya, Fumiko, Fujita, Yuka, Takamura, Kei, Kojima, Tetsuya, Honjo, Osamu, Minami, Yoshinori, Nishimura, Masaharu, Dosaka-Akita, Hirotoshi, Nakamura, Koji, Inano, Akihiro, Isobe, Hiroshi, and Suzuki, Hiroyuki

Published
2021
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17. Computed tomography mucus plugs and airway tree structure in patients with chronic obstructive pulmonary disease: Associations with airflow limitation, health‐related independence and mortality.

Author

Tanabe, Naoya, Shimizu, Kaoruko, Shima, Hiroshi, Wakazono, Nobuyasu, Shiraishi, Yusuke, Terada, Kunihiko, Terada, Satoru, Oguma, Tsuyoshi, Sakamoto, Ryo, Suzuki, Masaru, Makita, Hironi, Sato, Atsuyasu, Sato, Susumu, Nishimura, Masaharu, Konno, Satoshi, and Hirai, Toyohiro

Subjects
CHRONIC obstructive pulmonary disease, COMPUTED tomography, MUCUS, AIR flow, AIRWAY (Anatomy)
Abstract

Background and Objective: Mucus plugs and underlying airway tree structure can affect airflow limitation and prognosis in patients with chronic obstructive pulmonary disease (COPD), but their relative roles are unclear. This study used two COPD cohorts to examine whether mucus plugs on computed tomography (CT) were associated with airflow limitation and clinical outcomes independent of other airway structural changes and emphysema. Methods: Based on visual CT assessment, patients with mucus plugs in 0, 1–2 and ≥3 lung segments were assigned to no‐, low‐ and high‐mucus groups. Loss of health‐related independence and mortality were prospectively recorded for 3 and 10 years in the Kyoto–Himeji and Hokkaido cohorts, respectively. The percentages of the wall area of the central airways (WA%), total airway count (TAC) and emphysema were quantified on CT. Results: Of 199 and 96 patients in the Kyoto–Himeji and Hokkaido cohorts, 34% and 30%, respectively, had high mucus scores. In both cohorts, TAC was lower in the high‐mucus group than in the no‐mucus group, whereas their emphysema severity did not differ. High mucus score and low TAC were independently associated with airflow limitation after adjustment for WA% and emphysema. In multivariable models adjusted for WA% and emphysema, TAC, rather than mucus score, was associated with a greater rate of loss of independence, whereas high mucus score, rather than TAC, was associated with increased mortality. Conclusion: Mucus plugs and lower airway branch count on CT had distinct roles in airflow limitation, health‐related independence and mortality in patients with COPD. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival

Author

Yokouchi, Hiroshi, Nishihara, Hiroshi, Harada, Toshiyuki, Yamazaki, Shigeo, Kikuchi, Hajime, Oizumi, Satoshi, Uramoto, Hidetaka, Tanaka, Fumihiro, Harada, Masao, Akie, Kenji, Sugaya, Fumiko, Fujita, Yuka, Takamura, Kei, Kojima, Tetsuya, Higuchi, Mitsunori, Honjo, Osamu, Minami, Yoshinori, Watanabe, Naomi, Nishimura, Masaharu, Suzuki, Hiroyuki, Dosaka-Akita, Hirotoshi, and Isobe, Hiroshi

Published
2020
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21. A prospective phase II study of carboplatin and nab-paclitaxel in patients with advanced non-small cell lung cancer and concomitant interstitial lung disease (HOT1302)

Author

Asahina, Hajime, Oizumi, Satoshi, Takamura, Kei, Harada, Toshiyuki, Harada, Masao, Yokouchi, Hiroshi, Kanazawa, Kenya, Fujita, Yuka, Kojima, Tetsuya, Sugaya, Fumiko, Tanaka, Hisashi, Honda, Ryoichi, Kikuchi, Eiki, Ikari, Tomoo, Ogi, Takahiro, Shimizu, Kaoruko, Suzuki, Masaru, Konno, Satoshi, Dosaka-Akita, Hirotoshi, Isobe, Hiroshi, and Nishimura, Masaharu

Published
2019
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24. Insulin resistance assessed by short insulin tolerance test and its association with obesity and insulin resistance-related parameters in humans: A pilot randomized trial.

Author

Hayashishita, Akiko, Watanabe, Taku, Suzuki, Naoko, Nakaya, Toshitaka, Sugimoto, Ayako, Yokota, Isao, Ohira, Hiroshi, Nishimura, Masaharu, and Tsujino, Ichizo

Subjects
INSULIN, INSULIN resistance, TYPE 2 diabetes, GLYCEMIC control, OBESITY, INSULIN therapy
Abstract

The aim of this study was to examine the association of insulin resistance (evaluated by the short insulin tolerance test [SITT]) with parameters related to obesity and insulin resistance. We prospectively recruited controls and patients with type 2 diabetes mellitus (T2DM), subjected them to the SITT, and calculated the K indices of the intravenous insulin tolerance test (KITT(iv)) and the subcutaneous insulin tolerance test (KITT(sc)). We compared KITT(iv) results between the volunteers and patients and examined its correlation with KITT(sc). We also examined the association of KITT(iv) with obesity, insulin resistance-related parameters, and the insulin dose required for glycemic control. A total of 24 participants (seven controls and 17 patients with T2DM) were studied. The mean KITT(iv) was significantly lower in patients with T2DM than in the controls (2.5%±2.1% vs. 4.5%±1.8%). In all participants, KITT(iv) was significantly correlated with the homeostasis model assessment for insulin resistance (HOMA-IR) values (r = −0.601, p<0.05) but not with KITT(sc) (p = 0.62). KITT(iv) was correlated positively with the serum adiponectin concentration, but negatively with the visceral fat area and serum concentrations of tumor necrosis factor-α and branched-chain amino acids. In patients with T2DM, KITT(iv) and HOMA-IR values were significantly correlated with the total insulin dose required for glycemic control. Insulin resistance evaluated using KITT(iv) was correlated with the HOMA-IR values, but not with the resistance evaluated using KITT(sc). The degree of insulin resistance was associated with biomarkers, such as adiponectin, tumor necrosis factor-α, branched-chain amino acids, the visceral fat area, and the dose of insulin required for glycemic control. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Applicable predictive factors extracted from peak flow trajectory for the prediction of asthma exacerbation

Author

Yang, Yichi, primary, Kimura, Hirokazu, additional, Yokota, Isao, additional, Makita, Hironi, additional, Takimoto-Sato, Michiko, additional, Matsumoto-Sasaki, Machiko, additional, Matsumoto, Munehiro, additional, Oguma, Akira, additional, Abe, Yuki, additional, Takei, Nozomu, additional, Goudarzi, Houman, additional, Shimizu, Kaoruko, additional, Suzuki, Masaru, additional, Nishimura, Masaharu, additional, and Konno, Satoshi, additional

Published
2023
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33. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

Author

Vogelmeier, Claus F., Criner, Gerard J., Martinez, Fernando J., Anzueto, Antonio, Barnes, Peter J., Bourbeau, Jean, Celli, Bartolome R., Chen, Rongchang, Decramer, Marc, Fabbri, Leonardo M., Frith, Peter, Halpin, David M.G., Varela, M. Victorina López, Nishimura, Masaharu, Roche, Nicolas, Rodriguez-Roisin, Roberto, Sin, Don D., Singh, Dave, Stockley, Robert, Vestbo, Jørgen, Wedzicha, Jadwiga A., and Agusti, Alvar

Published
2017
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34. Informe 2017 de la Iniciativa Global para el Diagnóstico, Tratamiento y Prevención de la Enfermedad Pulmonar Obstructiva Crónica: Resumen Ejecutivo de GOLD

Author

Vogelmeier, Claus F., Criner, Gerard J., Martínez, Fernando J., Anzueto, Antonio, Barnes, Peter J., Bourbeau, Jean, Celli, Bartolome R., Chen, Rongchang, Decramer, Marc, Fabbri, Leonardo M., Frith, Peter, Halpin, David M.G., López Varela, M. Victorina, Nishimura, Masaharu, Roche, Nicolás, Rodríguez-Roisin, Roberto, Sin, Don D., Singh, Dave, Stockley, Robert, Vestbo, Jørgen, Wedzicha, Jadwiga A., and Agustí, Alvar

Published
2017
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39. A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for non-squamous non-small cell lung cancer with wild-type EGFR (HOT1101)

Author

Takashina, Taichi, Asahina, Hajime, Oizumi, Satoshi, Yamada, Noriyuki, Harada, Masao, Takamura, Kei, Yokouchi, Hiroshi, Harada, Toshiyuki, Honjo, Osamu, Ogi, Takahiro, Morikawa, Naoto, Kinoshita, Ichiro, Honda, Ryoichi, Nakano, Kosuke, Kanazawa, Kenya, Amano, Toraji, Dosaka-Akita, Hirotoshi, Isobe, Hiroshi, Nishimura, Masaharu, and Hokkaido Lung Cancer Clinical Study Group

Published
2018
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43. The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis

Author

Manabe, Osamu, Yoshinaga, Keiichiro, Ohira, Hiroshi, Masuda, Atsuro, Sato, Takahiro, Tsujino, Ichizo, Yamada, Asuka, Oyama-Manabe, Noriko, Hirata, Kenji, Nishimura, Masaharu, and Tamaki, Nagara

Published
2016
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45. Relationships of computed tomography-based small vessel indices of the lungs with ventilation heterogeneity and high transfer coefficients in non-smokers with asthma

Author

1000040399853, Shimizu, Kaoruko, Kimura, Hirokazu, Tanabe, Naoya, Chubachi, Shotaro, Sato, Susumu, Suzuki, Masaru, Tanimura, Kazuya, Iijima, Hiroaki, Oguma, Akira M., Ito, Yoichi, Wakazono, Nobuyasu, Takimoto-Sato, Michiko, Matsumoto-Sasaki, Machiko, Abe, Yuki, Takei, Nozomu, Makita, Hironi, Nishimura, Masaharu, 1000020399835, Konno, Satoshi, Hi CARAT Investigators, 1000040399853, Shimizu, Kaoruko, Kimura, Hirokazu, Tanabe, Naoya, Chubachi, Shotaro, Sato, Susumu, Suzuki, Masaru, Tanimura, Kazuya, Iijima, Hiroaki, Oguma, Akira M., Ito, Yoichi, Wakazono, Nobuyasu, Takimoto-Sato, Michiko, Matsumoto-Sasaki, Machiko, Abe, Yuki, Takei, Nozomu, Makita, Hironi, Nishimura, Masaharu, 1000020399835, Konno, Satoshi, and Hi CARAT Investigators

Abstract

Background: The mechanism of high transfer coefficients of the lungs for carbon monoxide (Kco) in non-smokers with asthma is explained by the redistribution of blood flow to the area with preserved ventilation, to match the ventilation perfusion.Objectives: To examine whether ventilation heterogeneity, assessed by pulmonary function tests, is associated with computed tomography (CT)-based vascular indices and Kco in patients with asthma.Methods: Participants were enrolled from the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) study that included a prospective asthmatic cohort. Pulmonary function tests including Kco, using single breath methods; total lung capacity (TLC), using multiple breath methods; and CT, were performed on the same day. The ratio of the lung volume assessed using single breath methods (alveolar volume; V-A) to that using multiple breath methods (TLC) was calculated as an index of ventilation heterogeneity. The volume of the pulmonary small vessels < 5 mm(2) in the whole lung (BV5 volume), and number of BV5 at a theoretical surface area of the lungs from the plural surface (BV5 number) were evaluated using chest CT images.Results: The low V-A/TLC group (the lowest quartile) had significantly lower BV5 number, BV5 volume, higher BV5 volume/BV5 number, and higher Kco compared to the high V-A/TLC group (the highest quartile) in 117 non-smokers, but not in 67 smokers. Multivariable analysis showed that low V-A/TLC was associated with low BV5 number, after adjusting for age, sex, weight, lung volume on CT, and CT emphysema index in non-smokers (not in smokers).Conclusion: Ventilation heterogeneity may be associated with low BV5 number and high Kco in non-smokers (not in smokers). Future studies need to determine the dynamic regional system in ventilation, perfusion, and diffusion in asthma.

Published
2023

46. Relationships of computed tomography-based small vessel indices of the lungs with ventilation heterogeneity and high transfer coefficients in non-smokers with asthma

Author

Shimizu, Kaoruko, Kimura, Hirokazu, Tanabe, Naoya, Chubachi, Shotaro, Sato, Susumu, Suzuki, Masaru, Tanimura, Kazuya, Iijima, Hiroaki, Oguma, Akira M., Ito, Yoichi, Wakazono, Nobuyasu, Takimoto-Sato, Michiko, Matsumoto-Sasaki, Machiko, Abe, Yuki, Takei, Nozomu, Makita, Hironi, Nishimura, Masaharu, Konno, Satoshi, Hi CARAT Investigators, Shimizu, Kaoruko, Kimura, Hirokazu, Tanabe, Naoya, Chubachi, Shotaro, Sato, Susumu, Suzuki, Masaru, Tanimura, Kazuya, Iijima, Hiroaki, Oguma, Akira M., Ito, Yoichi, Wakazono, Nobuyasu, Takimoto-Sato, Michiko, Matsumoto-Sasaki, Machiko, Abe, Yuki, Takei, Nozomu, Makita, Hironi, Nishimura, Masaharu, Konno, Satoshi, and Hi CARAT Investigators

Abstract

Background: The mechanism of high transfer coefficients of the lungs for carbon monoxide (Kco) in non-smokers with asthma is explained by the redistribution of blood flow to the area with preserved ventilation, to match the ventilation perfusion.Objectives: To examine whether ventilation heterogeneity, assessed by pulmonary function tests, is associated with computed tomography (CT)-based vascular indices and Kco in patients with asthma.Methods: Participants were enrolled from the Hokkaido-based Investigative Cohort Analysis for Refractory Asthma (Hi-CARAT) study that included a prospective asthmatic cohort. Pulmonary function tests including Kco, using single breath methods; total lung capacity (TLC), using multiple breath methods; and CT, were performed on the same day. The ratio of the lung volume assessed using single breath methods (alveolar volume; V-A) to that using multiple breath methods (TLC) was calculated as an index of ventilation heterogeneity. The volume of the pulmonary small vessels < 5 mm(2) in the whole lung (BV5 volume), and number of BV5 at a theoretical surface area of the lungs from the plural surface (BV5 number) were evaluated using chest CT images.Results: The low V-A/TLC group (the lowest quartile) had significantly lower BV5 number, BV5 volume, higher BV5 volume/BV5 number, and higher Kco compared to the high V-A/TLC group (the highest quartile) in 117 non-smokers, but not in 67 smokers. Multivariable analysis showed that low V-A/TLC was associated with low BV5 number, after adjusting for age, sex, weight, lung volume on CT, and CT emphysema index in non-smokers (not in smokers).Conclusion: Ventilation heterogeneity may be associated with low BV5 number and high Kco in non-smokers (not in smokers). Future studies need to determine the dynamic regional system in ventilation, perfusion, and diffusion in asthma.

Published
2023

48. Supplementary Figures S1 - S14, Tables S1 - S5 from Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer

Author

Kitai, Hidenori, primary, Ebi, Hiromichi, primary, Tomida, Shuta, primary, Floros, Konstantinos V., primary, Kotani, Hiroshi, primary, Adachi, Yuta, primary, Oizumi, Satoshi, primary, Nishimura, Masaharu, primary, Faber, Anthony C., primary, and Yano, Seiji, primary

Published
2023
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49. Prognostic impact of clinical variables on surgically resected small-cell lung cancer: Results of a retrospective multicenter analysis (FIGHT002A and HOT1301A)

Author

Yokouchi, Hiroshi, Ishida, Takashi, Yamazaki, Shigeo, Kikuchi, Hajime, Oizumi, Satoshi, Uramoto, Hidetaka, Tanaka, Fumihiro, Harada, Masao, Akie, Kenji, Sugaya, Fumiko, Fujita, Yuka, Fukuhara, Tatsuro, Takamura, Kei, Kojima, Tetsuya, Harada, Toshiyuki, Higuchi, Mitsunori, Matsuura, Yoshifumi, Honjo, Osamu, Minami, Yoshinori, Watanabe, Naomi, Nishihara, Hiroshi, Suzuki, Hiroyuki, Dosaka-Akita, Hirotoshi, Isobe, Hiroshi, Nishimura, Masaharu, and Munakata, Mitsuru

Published
2015
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