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177 results on '"NITTARI, Giulio"'

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14. Dysfunction of the Brown Adipose Organ in HFD-Obese Rats and Effect of Tart Cherry Supplementation

Author

Bellitto, Vincenzo, primary, Gabrielli, Maria Gabriella, additional, Martinelli, Ilenia, additional, Roy, Proshanta, additional, Nittari, Giulio, additional, Cocci, Paolo, additional, Palermo, Francesco Alessandro, additional, Amenta, Francesco, additional, Micioni Di Bonaventura, Maria Vittoria, additional, Cifani, Carlo, additional, Tomassoni, Daniele, additional, and Tayebati, Seyed Khosrow, additional more...

Published
2024
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15. Effectiveness of facial anatomy cadaver lab training in aesthetic medicine programs.

Author

NITTARI, GIULIO, SAVVA, DEMETRIS, TRAINI, ENEA, TOMASSONI, DANIELE, and AMENTA, FRANCESCO

Subjects
*HUMAN anatomy, *PHYSICIANS, *MEMORY bias, *FACIAL expression, *CONNECTIVE tissues
Abstract

Cadaver dissection in post-graduate training programs in aesthetic medicine offers physicians the opportunity of a three-dimensional knowledge of the face morphology, the individual regions, and layers of the face with all neighbouring structures including the main arteries, veins, and nerves. This study has evaluated the effectiveness of this educational intervention, in attendants to the second level vocational Master course in aesthetic medicine and therapeutics co-organized by the universities of Camerino and Turin. Two hundred medicine doctors attending the first year of the course have followed, as a part of the human anatomy course, a 2-day cadaver training on face anatomy at the Hellenic Neurosurgical Research Centre in Athens, Greece. The impact of the program was evaluated by a pre- and post-course multiple choice questions (MCQs) test. Different sets of MCQs were selected for the pre- and post-course test to avoid any recall bias. All 200 participants completed the tests, and their answers were analysed. A significant difference in the number of correct answers and in the scores obtained was found between pre- and post-course MCQs. Answers to questions on muscles of facial expression, muscles of the head, connective tissue and ligaments of the face and blood vessels and nerves of the face were those more correct after the cadaver lab practical course. The results showing a better knowledge of facial anatomical details after a practical cadaver lab suggest the need of including practical cadaver dissection activities in medical training in aesthetic medicine. [ABSTRACT FROM AUTHOR] more...

Published
2024
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18. Factors affecting mental health of seafarers on board merchant ships: a systematic review.

Author

Nittari, Giulio, Gibelli, Filippo, Bailo, Paolo, Sirignano, Ascanio, and Ricci, Giovanna

Abstract

Merchant ships represent a peculiar working environment with several challenges and risks. The specific situation on board of ships may affect the mental health of seafarers more remarkably than ashore workers. A systematic review of the literature has been carried out to identify the main causes of mood disorders among seafarers and the impact that these disorders have on their health. This review has analyzed the scientific literature published between January 2006 and December 2021 using the search engines PubMed, Web of Science (WoS) and Cumulative Index to Nursing and Allied Health Literature (CINAHL). Social isolation, distance from families, fatigue, stress and long work shifts represent the main causes of mood disorders among seafarers. Strategies aimed at improving conditions of cohabitation on board, and a greater consideration of these problems are key for improving the mental health of workers at sea. [ABSTRACT FROM AUTHOR] more...

Published
2024
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27. Effects of choline containing phospholipids on the neurovascular unit: A review

Author

Roy, Proshanta, Tomassoni, Daniele, Nittari, Giulio, Traini, Enea, and Amenta, Francesco

Subjects
Cellular and Molecular Neuroscience
Abstract

The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of neurons, glial and vascular cells ensuring the correct homeostasis of the blood-brain barrier (BBB) and indirectly the function of the central nervous system. The CCPLs phosphatidylcholine (lecithin), cytidine 5′-diphosphocholine (CDP-choline), choline alphoscerate or α-glyceryl-phosphorylcholine (α-GPC) contribute to the modulation of the physiology of the NVU cells. A loss of CCPLs contributes to the development of neurodegenerative diseases such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease. Our study has characterized the cellular components of the NVU and has reviewed the effect of lecithin, of CDP-choline and α-GPC documented in preclinical studies and in limited clinical trials on these compounds. The interesting results obtained with some CCPLs, in particular with α-GPC, probably would justify reconsideration of the most promising molecules in larger attentively controlled studies. This can also contribute to better define the role of the NVU in the pathophysiology of brain disorders characterized by vascular impairment. more...

Published
2022
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39. Fourth Generation of Synthetic Cannabinoid Receptor Agonists: A Review on the Latest Insights

Author

Malaca, Sara, Busardò, Francesco, P., Nittari, Giulio, Sirignano, Ascanio, and Ricci, Giovanna

Subjects
Drug, Psychosis, medicine.medical_specialty, Cannabinoid receptor, media_common.quotation_subject, medicine.medical_treatment, Irritability, Receptor, Cannabinoid, CB1, Drug Discovery, Synthetic cannabinoids, Medicine, Humans, Dronabinol, Psychiatry, media_common, Pharmacology, Cannabinoid Receptor Agonists, Psychotropic Drugs, business.industry, medicine.disease, Anxiety, Cannabinoid, medicine.symptom, business, medicine.drug
Abstract

Background: Over the past few years, an emerging number of new psychoactive substances (NPSs) entered the illicit market. NPSs are designed to resemble the effects of classical drugs of abuse, reinforcing their effects and duration. Among the most abused NPS, synthetic cannabinoids are cannabinoid receptor agonists (SCRAs) that mimic the effect of the main psychotropic phytocannabinoid Δ9-tetrahydrocannabinol (THC). Methods: We herein reviewed the international literature to provide available information on the newest SCRAs generation. Results: Compared to the previous SCRAs generations, the structures of the last generation result in increased affinity for and efficacy at cannabinoid CB1 receptors, which are thought to be mainly responsible for the psychoactive effects of THC and its analogues. Accordingly, these more potent cannabimimetic effects may increase the number of adverse reactions such as neurological disorders (e.g., psychosis, agitation, irritability, paranoia, confusion, and anxiety), psychiatric episodes (e.g., hallucinations, delusions, self-harm), other physical conditions (e.g., tachycardia, hypertension, arrhythmia, chest pain, nausea, vomiting, and fever) and deaths. In the last decade, more than a hundred SCRAs from different chemical classes emerged on the illicit web market. SCRAs have been thoroughly studied: they were physico-chemically characterized, and pharmaco-toxicological characteristics were investigated. The last SCRAs generations include increasingly potent and toxic compounds, posing a potential health threat to consumers. Conclusion: From November 2017 to February 2021, at least 20 new “fourth-generation” SCRAs were formally reported to international drug agencies. Our understanding of the neurotoxicity of these compounds is still limited due to the lack of global data, but their potency and their toxicity are likely higher than those of the previous generations. more...

Published
2021