1. Probing the limits of selectivity in a recognition-mediated reaction network embedded within a dynamic covalent library
- Author
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Tamara Kosikova, Douglas Philp, Harry Mackenzie, University of St Andrews. School of Chemistry, University of St Andrews. EaSTCHEM, and University of St Andrews. Biomedical Sciences Research Complex
- Subjects
Imagination ,Chemical substance ,media_common.quotation_subject ,Nanotechnology ,Combinatorial chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,Search engine ,Molecular recognition ,Nucleophile ,QD ,media_common ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,DAS ,General Chemistry ,QD Chemistry ,Cycloaddition reaction ,0104 chemical sciences ,Kinetics ,Covalent bond ,Science, technology and society ,Selectivity ,NMR spectroscop - Abstract
This work was supported by the award of a Postgraduate Studentship from EPSRC (EP/K503162/1) to TK. Two recognition-mediated reaction processes operating through a reactive binary complex drive resolution of a 24-component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition-enabled species over another is limited by the difference in the rates of the recognition-mediated reactive processes and strength of the recognition processes employed in the dynamic system. Postprint
- Published
- 2016