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The present research, reports the hygrothermal behavior of poly [ethylene oxide] (PEO) based composite film (500 and1000 μm) containing NH 4 I and KBr (5–20 wt%) as the mobile phase and non-reactive silica (15 wt%) as the filler. These are termed as PK/NSiO 2 -series for solvent sorbed and (PK/NSiO 2) NS for non-swelled film. The novelty of the research lies in the analyses of non-Fickian solvent diffusion trait of films using python programming. The presence of ions and its variable polarizable nature is found to influence the number density of bonded and free solvent content along with the extend of cross linkage. Introduction of silica is found to enhance the ionic conductivity (about one order higher) of the film irrespective of the type of charge carrier owing to the improved dispersion within the matrix. Non-Fickian diffusion is found to influence the ionic conductivity of P 2 K20SiO 2 (10−5Scm−1 to 10−2 Scm−1) minimizing the degradation to 0.2 %ΔC/1000 h (>1 %ΔC/1000 h, tested for 2000 h) compared to P 2 N20NSiO 2. In contrast, ion migration in P 2 NSiO 2 is guided by Rice and Roth model and being more polarizable ions, the mobility is significant which maximizes the conductivity to ∼10−1 Scm−1. Microstructural study shows heterogenous nucleation to be more pronounced upon addition of silica filler wherein the homogeneity, inter fibrillar interaction and grain growth of spherulites is higher. This tends to extend amorphous regions thereby propagating the ion migration path. The influence of sorption process is studied in terms of electrochemical impedance, dielectric analyses and long term cyclability (20,000 h) in terms of loss tangent. [ABSTRACT FROM AUTHOR]

The main objective of present study was to develop a buccal mucoadhesive drug delivery system for perindopril. Perindopril buccal mucoadhesive patches were developed by solvent casting technique using hydroxy propyl methylcellulose (HPMC), polycarbophil, sodium carboxymethylcellulose (SCMC) and sodium alginate as polymers for extended release of perindopril. Glycerine and DMSO were used as plasticizer and penetration enhancer respectively. Ethanol, methanol and dichloromethane were used as solvents. FTIR and DSC studies revealed no interaction between drug and polymers. The drug content in the perindopril patches was found to be uniform. The films exhibited good physical and mechanical properties. The surface pH of all the patches was within salivary pH range. Residual solvent content in patches are below the tolerated limits. The patches were found to have an extended release of the drug upto a period of 12 hours during ex vivo permeation studies with non-Fickian diffusion mechanism. The present study demonstrated the possibility of designing a buccal drug delivery system for perindopril. [ABSTRACT FROM AUTHOR]

Highlights: [•] Chia seed mucilage can emerge as a potential industrial additive. [•] Chia mucilage release can be studied by applying drug release mathematical models. [•] Microscopy and Image analysis can be used to model chia mucilage release process. [Copyright &y& Elsevier]